AXIN2

Summary

Gene Symbol: AXIN2
Description: axin 2
Alias: AXIL, ODCRCS, axin-2, axin-like protein, axis inhibition protein 2, conductin
Species: human
Products:     AXIN2

Top Publications

  1. Tseng R, Lin R, Wen C, Tseng C, Hsu H, Hsu W, et al. Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis. Oncogene. 2008;27:4488-96 pubmed publisher
    ..Therefore, we postulated that alteration of the degradation complex AXIN2 (axis inhibition protein 2) and betaTrCP (beta-transducin repeat-containing protein) and p53 regulation could result in beta-..
  2. Liu W, Dong X, Mai M, Seelan R, Taniguchi K, Krishnadath K, et al. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat Genet. 2000;26:146-7 pubmed
  3. Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene. 2006;25:7531-7 pubmed
    ..Mutations in the Wnt components AXIN1, AXIN2 and TCF4 have been found in microsatellite-unstable colon cancers, but it is not clear in every case whether these ..
  4. Dao D, Yang X, Flick L, Chen D, Hilton M, O Keefe R. Axin2 regulates chondrocyte maturation and axial skeletal development. J Orthop Res. 2010;28:89-95 pubmed publisher
    Axis inhibition proteins 1 and 2 (Axin1 and Axin2) are scaffolding proteins that modulate at least two signaling pathways that are crucial in skeletogenesis: the Wnt/beta-catenin and TGF-beta signaling pathways...
  5. Koinuma K, Yamashita Y, Liu W, Hatanaka H, Kurashina K, Wada T, et al. Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. Oncogene. 2006;25:139-46 pubmed
    ..Such MSI-associated genes included that for AXIN2, an important component of the WNT signaling pathway...
  6. Huang S, Mishina Y, Liu S, Cheung A, Stegmeier F, Michaud G, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009;461:614-20 pubmed publisher
    ..Thus, our study provides new mechanistic insights into the regulation of axin protein homeostasis and presents new avenues for targeted Wnt pathway therapies. ..
  7. Wang X, Goode E, Fredericksen Z, Vierkant R, Pankratz V, Liu Mares W, et al. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2101-8 pubmed publisher
    ..of the contribution of genetic variation in six genes encoding the beta-catenin destruction complex (APC, AXIN1, AXIN2, CSNK1D, CSNK1E, and GSK3B) to breast cancer using a Mayo Clinic Breast Cancer Case-Control Study...
  8. Kanzaki H, Ouchida M, Hanafusa H, Yano M, Suzuki H, Aoe M, et al. Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. Int J Mol Med. 2006;18:279-84 pubmed
    The AXIN2 gene, a negative regulator gene of Wnt/beta-catenin signaling, is a putative tumor suppressor gene on human chromosome 17q24...
  9. Pujar M, Vastrad B, Vastrad C. Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance. Biomolecules. 2019;9: pubmed publisher
    ..Subsequently, myosin VB (MYO5B), discs, large homolog 2(DLG2), axin 2 (AXIN2), protein tyrosine kinase 7 (PTK7), Notch homolog 1 (NOTCH1), androgen receptor (AR), cyclin D1 (CCND1) and ..

More Information

Publications129 found, 100 shown here

  1. Huang X, Zhong L, Hendriks J, Post J, Karperien M. The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..chondrogenic effects appeared to be mediated through the canonical WNT signaling pathway, since the target gene Axin2 and other WNT members, such as TCF4 and ?-catenin, were upregulated by BIO and downregulated by ..
  2. Jagadish N, Parashar D, Gupta N, Agarwal S, Purohit S, Kumar V, et al. A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. J Exp Clin Cancer Res. 2015;34:142 pubmed publisher
    ..However, anti-apoptotic molecules BCL2, Bcl-xL, cIAP2, XIAP, Axin2 and Survivin were down regulated in these samples...
  3. Hadjadj D, Kim S, Denecker T, Ben Driss L, Cadoret J, Maric C, et al. A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas. Aging (Albany NY). 2017;9:2695-2716 pubmed publisher
    ..Synthase Kinase 3β (GSK3β) responsible for the reduced amount of active β-catenin, and altered the amount of AXIN2 mRNA...
  4. Dohare P, Cheng B, Ahmed E, Yadala V, Singla P, Thomas S, et al. Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A. Neurobiol Dis. 2018;118:22-39 pubmed publisher
    ..Induction of IVH reduced expressions of activated β-catenin, TCF-4, and Axin2 transcription factors in preterm newborns. Both AR-A014418 (ARA) and Wnt-3A treatment activated Wnt signaling...
  5. Thaker A, Rao M, Bishnupuri K, Kerr T, Foster L, Marinshaw J, et al. IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. Gastroenterology. 2013;145:416-25.e1-4 pubmed publisher
    ..of IDO1 activity reduced nuclear and activated β-catenin, transcription of its target genes (cyclin D1 and Axin2), and, ultimately, proliferation...
  6. Okabe H, Kinoshita H, Imai K, Nakagawa S, Higashi T, Arima K, et al. Diverse Basis of ?-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis. PLoS ONE. 2016;11:e0152695 pubmed publisher
    ..Gene alteration in exon3 of CTNNB1, gene expression of ?-catenin targets such as glutamate synthetase (GS), axin2, lect2 and regucalcin (RGN), and protein expression of ?-catenin were examined in 125 human HCC tissues...
  7. Watson R, Spalding A, Zielske S, Morgan M, Kim A, Bommer G, et al. GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer. Neoplasia. 2010;12:357-65 pubmed
    ..GSK3beta silencing increased radiation-induced beta-catenin target gene expression as measured by studies of AXIN2 and LEF1 transcript levels...
  8. Lin H, Angeli M, Chung K, Ejimadu C, Rosa A, Lee T. sFRP2 activates Wnt/?-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling. Am J Physiol Cell Physiol. 2016;311:C710-C719 pubmed publisher
    ..sFRP2 activates CFs in part through canonical Wnt/?-catenin signaling, as evidenced by increased expression of Axin2 and Wnt3a, but not Wnt5a, as well as accumulation of nuclear ?-catenin...
  9. Sennello J, Misharin A, Flozak A, Berdnikovs S, Cheresh P, Varga J, et al. Lrp5/?-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis. Am J Respir Cell Mol Biol. 2017;56:191-201 pubmed publisher
    ..Activation of ?-catenin signaling was seen in lung macrophages using the ?-catenin reporter mouse, Axin2+/LacZ...
  10. Evans A, Faial T, Gilchrist M, Down T, Vallier L, Pedersen R, et al. Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. PLoS ONE. 2012;7:e33346 pubmed publisher
    ..Expression of some of these targets, such as Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos and we demonstrate that they are also Brachyury ..
  11. Zhang Y, Seid K, Obermayr F, Just L, Neckel P. Activation of Wnt Signaling Increases Numbers of Enteric Neurons Derived From Neonatal Mouse and Human Progenitor Cells. Gastroenterology. 2017;153:154-165.e9 pubmed publisher
    ..to intracellular accumulation of Wnt-dependent β-catenin and up-regulated expression of known Wnt target genes axin2, lef1, and lgr5...
  12. Tao Y, Messer J, Goss K, Hart J, Bissonnette M, Chang E. Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. Carcinogenesis. 2016;37:731-739 pubmed publisher
    ..ErbB2, Akt, ERK and β-catenin along with decreased β-catenin transcriptional activity as measured by c-myc and axin2 expression. Upregulation of RTK or WNT signals are frequent oncogenic events in CRC and many other cancers...
  13. Amer M, Elhefnawi M, El Ahwany E, Awad A, Gawad N, Zada S, et al. Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span. Tumour Biol. 2014;35:11301-9 pubmed publisher
    ..FGF7, GHR, PCMT1, CITED2, PEX5, PEX13, NOVA1, AXIN2, and TSPYL2 were detected with high significant (P < 0.005)...
  14. Li Y, Liu Y, Hu Y, Chen L, Li J. Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells. World J Gastroenterol. 2016;22:8528-8539 pubmed
    ..Moreover, most markers for stem cells such as CD133, CD44, AXIN2, MEIS2 and NANOG were increased in cells with SATB2 knockdown and decreased in cells with SATB2 overexpression...
  15. Zhou Q, Abraham A, Li L, Babalmorad A, Bagby S, Arcaroli J, et al. Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. Oncogene. 2016;35:4990-9 pubmed publisher
    ..Wnt response elements (WREs) and promoters of direct target genes of TCF transcription, including: MYC, vimentin, AXIN2 and LEF1...
  16. Mahl C, Egea V, Megens R, Pitsch T, Santovito D, Weber C, et al. RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/β-catenin signaling in human mesenchymal stem cells. Cell Mol Life Sci. 2016;73:1489-501 pubmed publisher
    ..The latter was determined by analysis of the β-catenin target genes Dickkopf1 (DKK1), axis inhibition protein 2 (AXIN2), runt-related transcription factor 2 (RUNX2) and a luciferase-based β-catenin-activated ..
  17. Moon Y, Yun C, Lee J, Kim J, Park B, Cho E. Maturation of cortical bone suppresses periosteal osteoprogenitor proliferation in a paracrine manner. J Mol Histol. 2016;47:445-53 pubmed publisher
    ..Moreover, the mRNA levels of ?-catenin, cyclin D1, Lef-1, and Axin2, all of which are Wnt target genes, were significantly increased in the periosteum of both Smad4 (Col) and Osx (..
  18. Jang W, Seo C, Jang H, Song N, Kim J, Ahn J, et al. Black rice (Oryza sativa L.) extracts induce osteoblast differentiation and protect against bone loss in ovariectomized rats. Food Funct. 2015;6:265-75 pubmed publisher
    ..BRE treatment also induced Wnt-specific target genes such as Axin2, WISP2, and Cyclin D1...
  19. Boonmuen N, Thongon N, Chairoungdua A, Suksen K, Pompimon W, Tuchinda P, et al. 5-Acetyl goniothalamin suppresses proliferation of breast cancer cells via Wnt/?-catenin signaling. Eur J Pharmacol. 2016;791:455-464 pubmed publisher
    ..consistent with this view, the expression of Wnt/?-catenin signaling target genes including c-Myc, cyclin D1 and Axin2 in MCF-7 and MDA-MB-231 cells were suppressed after treatment with 5GTN...
  20. Jeong M, Kim H, Pyun J, Choi K, Lee D, Solhjoo S, et al. Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling. Proc Natl Acad Sci U S A. 2017;114:E1345-E1354 pubmed publisher
    ..hearts exhibit hyperactive Wnt signaling as evident by β-catenin accumulation and Axin2 up-regulation...
  21. Yi Y, Polosukhina D, Love H, Hembd A, Pickup M, Moses H, et al. A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor. J Urol. 2015;194:1762-70 pubmed publisher
    ..Up-regulation of WNT/β-catenin targets (MYC, Survivin, FOXA2, Axin2 and Cyclin D1) was confirmed by immunoblot...
  22. Tantravedi S, Vesuna F, Winnard P, Martin A, Lim M, Eberhart C, et al. Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33. Transl Oncol. 2019;12:96-105 pubmed publisher
    ..TCF reporter activity, and reduced mRNA expression levels of downstream target genes of the WNT pathway, such as Axin2, CCND1, MYC, and Survivin...
  23. Ryu S, Lee Y, Hyun M, Choi S, Jeong K, Park Y, et al. Mycophenolate antagonizes IFN-γ-induced catagen-like changes via β-catenin activation in human dermal papilla cells and hair follicles. Int J Mol Sci. 2014;15:16800-15 pubmed publisher
    ..IFN-γ inhibited expression of ALP and other dermal papillar cells (DPCs) markers such as Axin2, IGF-1, and FGF 7 and 10...
  24. Lu D, Bao D, Dong W, Liu N, Zhang X, Gao S, et al. Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway. Lab Invest. 2016;96:239-48 pubmed publisher
    ..Dishevelled 1) and key proteins of the canonical Wnt pathway (cytoplasmic and nuclear β-catenin, c-Myc, and Axin2) and downregulated key proteins of the noncanonical Wnt pathway (c-Jun N-terminal kinase (JNK), Ca(2+)/calmodulin-..
  25. Chai S, Ng K, Tong M, Lau E, Lee T, Chan K, et al. Octamer 4/microRNA-1246 signaling axis drives Wnt/?-catenin activation in liver cancer stem cells. Hepatology. 2016;64:2062-2076 pubmed publisher
    ..tumorigencity, and metastasis, by activation of the Wnt/?-catenin pathway through suppressing the expression of AXIN2 and glycogen synthase kinase 3? (GSK3?), two key members of the ?-catenin destruction complex...
  26. Park S, Hwang I, Kim J, Chung Y, Song G, Na M, et al. Smenospongidine suppresses the proliferation of multiple myeloma cells by promoting CCAAT/enhancer-binding protein homologous protein-mediated ?-catenin degradation. Arch Pharm Res. 2017;40:592-600 pubmed publisher
    ..down-regulated ?-catenin expression and repressed the levels of ?-catenin/T cell factor-dependent genes such as axin2, c-myc, and cyclin D1 in RPMI-8226 multiple myeloma cells...
  27. Naito M, Ohashi A, Takahashi T. Dexamethasone inhibits chondrocyte differentiation by suppression of Wnt/β-catenin signaling in the chondrogenic cell line ATDC5. Histochem Cell Biol. 2015;144:261-72 pubmed publisher
    ..analysis showed that Dex increased the mRNA expression levels of secreted frizzled-related protein 1 (sFRP1) and Axin2. Furthermore, treatment with a sFRP1 inhibitor or the ΔN90 β-catenin mutant transfection attenuated Dex-..
  28. Govindaraj V, Shridharan R, Rao A. Proteomic changes during adult stage in pre-optic, hypothalamus, hippocampus and pituitary regions of female rat brain following neonatal exposure to estradiol-17?. Gen Comp Endocrinol. 2018;266:126-134 pubmed publisher
    ..The differentially expressed proteins such as 14-3-3 zeta/delta (POA), LMNA (hippocampus), Axin2 (hypothalamus), Syntaxin-7 (hippocampus), prolactin and somatotropin (pituitary) which have very important ..
  29. Martineau C, Kevorkova O, Brissette L, Moreau R. Scavenger receptor class B, type I (Scarb1) deficiency promotes osteoblastogenesis but stunts terminal osteocyte differentiation. Physiol Rep. 2014;2: pubmed publisher
    ..Lrp) 5 and Lrp8, was increased, respectively, by two- and threefold, and of transcription target-genes axis inhibition protein 2 (Axin2) and lymphoid enhancer-binding factor 1 (Lef1) over threefold...
  30. Dai Y, Liu L, Zeng T, Liang J, Song Y, Chen K, et al. Overexpression of MUC13, a Poor Prognostic Predictor, Promotes Cell Growth by Activating Wnt Signaling in Hepatocellular Carcinoma. Am J Pathol. 2018;188:378-391 pubmed publisher
    ..which subsequently promoted nuclear translocation of β-catenin and up-regulation of its downstream target genes Axin2, c-Myc, and CyclinD1...
  31. Sebastian A, Hum N, Morfin C, Murugesh D, Loots G. Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation. Gene. 2018;675:312-321 pubmed publisher
    ..osteoblasts compared to sham-treated controls; these included several members of Wnt pathway (Wnt2b, Wnt7b, Wnt11, Axin2, Sfrp2, Sfrp4, Fzd5 etc.) and TGF-β/BMP signaling pathway (Bmp7, Inhba, Inhbb, Tgfb2 etc.)...
  32. Rafighdoost H, Hashemi M, Danesh H, Bizhani F, Bahari G, Taheri M. Association of single nucleotide polymorphisms in AXIN2, BMP4, and IRF6 with Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population. J Appl Oral Sci. 2017;25:650-656 pubmed publisher
    ..The aim of this study was to examine the association between AXIN2 (axis inhibition protein 2) rs7224837, BMP4 (bone morphogenetic protein 4) rs17563, and IRF6 (interferon regulatory factor 6) ..
  33. Hadjihannas M, Brückner M, Behrens J. Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep. 2010;11:317-24 pubmed publisher
    ..Here, we report a mechanism linking Wnt/beta-catenin signalling to centrosome separation. We show that conductin/axin2, a negative regulator of beta-catenin, localizes at the centrosomes by binding to the centriole-associated ..
  34. Zhang Q, Shi X, Song C, Sun S, Yang G, Li X. BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/β-Catenin Signaling. Int J Mol Sci. 2015;16:17734-45 pubmed publisher
    ..as characterized by the decreased nuclear translocation of β-catenin and the lowered transcription of Axin2, which is a well-documented target gene of the Wnt/β-catenin signaling pathway...
  35. Adhikari N, Neupane S, Gwon G, Kim J, An C, Lee S, et al. Grhl3 modulates epithelial structure formation of the circumvallate papilla during mouse development. Histochem Cell Biol. 2017;147:5-16 pubmed publisher
    ..there were changes in the specific expression patterns of signaling and apoptosis-related molecules such as Axin2, Bak1, Bcl2, Casp3, Casp8, Ctnnb1, Cnnd1, Gli3, Lef1, Ptch1, Rock1, Shh, and Wnt11, which could explain the ..
  36. Lejeune S, Guillemot F, Triboulet J, Cattan S, Mouton C, Porchet N, et al. Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. Hum Mutat. 2006;27:1064 pubmed
    ..Recently, germline mutations in the Wnt pathway component gene AXIN2 have been associated with tooth agenesis-colorectal cancer syndrome...
  37. Pedace L, Castiglia D, De Simone P, Castori M, De Luca N, Amantea A, et al. AXIN2 germline mutations are rare in familial melanoma. Genes Chromosomes Cancer. 2011;50:370-3 pubmed publisher
  38. Alldredge A, Fuhrmann S. Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. Invest Ophthalmol Vis Sci. 2016;57:5253-5262 pubmed publisher
    The scaffold protein Axin2 is an antagonist and universal target of the Wnt/?-catenin pathway. Disruption of Axin2 may lead to developmental eye defects; however, this has not been examined...
  39. Green A, Kocovski P, Jovic T, Walia M, Chandraratna R, Martin T, et al. Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells. Exp Cell Res. 2017;350:284-297 pubmed publisher
    ..This accompanied reduced nuclear and cytosolic ?-catenin protein and reduced expression of the Wnt target gene Axin2, suggesting impaired Wnt/?-catenin signalling...
  40. Machado R, de Freitas E, de Aquino S, Martelli D, Swerts M, Reis S, et al. Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population. BMC Med Genet. 2017;18:39 pubmed publisher
    ..This multicenter study evaluated the association of 9 single nucleotide polymorphisms (SNP) in AXIN2 and CDH1, representing genes consistently altered in breast and gastric tumors, with NSCL?±?P in 223 trios (..
  41. Zhang X, Kim K, Zheng Z, Kim H, Cha I, Yook J. Snail and Axin2 expression predict the malignant transformation of oral leukoplakia. Oral Oncol. 2017;73:48-55 pubmed publisher
    ..this cross-sectional and retrospective cohort study was to investigate the predictive role of canonical Wnt genes Axin2 and Snail (SNAI1) expression in the malignant transformation of OL lesions...
  42. Zhang J, Wang C, Hua L, Yao K, CHEN J, Hu J. miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2. Int J Clin Exp Pathol. 2015;8:5168-74 pubmed
    ..At the molecular level, our results suggested that expression of Axin2 was negatively regulated by miR-107...
  43. Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Otterson M, et al. Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1. Neoplasia. 2015;17:598-611 pubmed publisher
    ..Wnt target genes (AXIN2, c-MYC, Cyclin D1, Dkk1) and Wnt3a were significantly upregulated in nondysplastic BE compared with squamous ..
  44. Martins Neves S, Corver W, Paiva Oliveira D, van den Akker B, Briaire de Bruijn I, Bovee J, et al. Osteosarcoma Stem Cells Have Active Wnt/?-catenin and Overexpress SOX2 and KLF4. J Cell Physiol. 2016;231:876-86 pubmed publisher
    ..specific activation of Wnt/?-catenin signaling as evidenced by increased nuclear ?-catenin, TCF/LEF activity, and AXIN2 expression, in a subset of the cell lines...
  45. Moiseenko A, Kheirollahi V, Chao C, Ahmadvand N, Quantius J, Wilhelm J, et al. Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development. Stem Cells. 2017;35:1566-1578 pubmed publisher
    ..Using Fgf10CreERT2 , Wt1CreERT2 , Gli1CreERT2 , and Axin2CreERT2 inducible driver lines in combination with a tdTomatoflox reporter line, the ..
  46. Ichijo R, Kobayashi H, Yoneda S, Iizuka Y, Kubo H, Matsumura S, et al. Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun. 2017;8:508 pubmed publisher
    ..The Tbx3+ basal cells are generated from Axin2+ interfollicular epidermal stem cells through planar-oriented asymmetric or symmetric cell divisions, ..
  47. Järvinen E, Shimomura Kuroki J, Balic A, Jussila M, Thesleff I. Mesenchymal Wnt/β-catenin signaling limits tooth number. Development. 2018;145: pubmed publisher
    ..In addition, loss-of-function mutations in the Wnt feedback inhibitor AXIN2 lead to human tooth agenesis...
  48. Furuhashi M, Yagi K, Yamamoto H, Furukawa Y, Shimada S, Nakamura Y, et al. Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. Mol Cell Biol. 2001;21:5132-41 pubmed
    ..An Axin homologue, Axil (also called conductin), also interacted with Smad3...
  49. Zubbair Malik M, Ali S, Alam M, Ishrat R, Brojen Singh R. Dynamics of p53 and Wnt cross talk. Comput Biol Chem. 2015;59 Pt B:55-66 pubmed publisher
    ..Similarly, the change in Axin2 concentration in Wnt could able to modulate the p53 dynamics at these states...
  50. Haddaji Mastouri M, De Coster P, Zaghabani A, Jammali F, Raouahi N, Ben Salem A, et al. Genetic study of non-syndromic tooth agenesis through the screening of paired box 9, msh homeobox 1, axin 2, and Wnt family member 10A genes: a case-series. Eur J Oral Sci. 2018;126:24-32 pubmed publisher
    ..We focused on four genes - paired box 9 (PAX9), Wnt family member 10A (WNT10A), msh homeobox 1 (MSX1), and axin 2 (AXIN2) - using direct Sanger sequencing of the exons and intron-exon boundaries...
  51. Fatima S, Shi X, Lin Z, Chen G, Pan X, Wu J, et al. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016;10:195-212 pubmed publisher
    ..of Wnt/β-catenin signalling was evidenced by increased expression of β-catenin downstream target genes, Axin2, cyclin D1, dickoppf-1 (DKK1) and glutamine synthetase (GS) by qPCR in serum-deprived HCC cell lines treated with ..
  52. Schneider R, Koop B, Schröter F, Cline J, Ingwersen J, Berndt C, et al. Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis. Mol Neurodegener. 2016;11:53 pubmed publisher
    ..In the present study, we used the Wnt signaling reporter mouse Axin2(LacZ), to elucidate the molecular mechanisms underlying the activation of the hippocampal neurogenic niche upon ..
  53. Huraskin D, Eiber N, Reichel M, Zidek L, Kravic B, Bernkopf D, et al. Wnt/?-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers. Development. 2016;143:3128-42 pubmed publisher
    ..Here, we studied activation of Wnt/?-catenin signaling in adult muscle fibers and muscle stem cells in an Axin2 reporter mouse. Axin2 is a negative regulator and a target of Wnt/?-catenin signaling...
  54. Schweigert A, Fischer C, Mayr D, Von Schweinitz D, Kappler R, Hubertus J. Activation of the Wnt/?-catenin pathway is common in wilms tumor, but rarely through ?-catenin mutation and APC promoter methylation. Pediatr Surg Int. 2016;32:1141-1146 pubmed
    ..The transcription of axis inhibition protein 2 (AXIN2) and APC was analyzed by real-time PCR...
  55. Sato M, Yamamoto H, Hatanaka Y, Nishijima T, Jiromaru R, Yasumatsu R, et al. Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland. Pathol Res Pract. 2018;214:586-592 pubmed publisher
    ..staining for β-catenin and mutation analysis for Wnt/β-catenin-related genes (CTNNB1, APC, AXIN1 and AXIN2) in BCA (n = 34), BCAC (n = 3), ACC (n = 67) and PA (n = 31)...
  56. Kikuchi A. Modulation of Wnt signaling by Axin and Axil. Cytokine Growth Factor Rev. 1999;10:255-65 pubmed
    ..Axin and its homolog Axil, newly recognized as components of the Wnt signaling pathway, negatively regulate this pathway...
  57. Liu W, Rui H, Wang J, Lin S, He Y, Chen M, et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 2006;25:1646-58 pubmed
    ..However, coexpression of Wnt-1 reduced Smad7 ubiquitination by downregulating Axin levels, underscoring the importance of Axin as an intrinsic regulator in TGF-beta signaling. ..
  58. Abshagen K, Senne M, Genz B, Thomas M, Vollmar B. Differential Effects of Axin2 Deficiency on the Fibrogenic and Regenerative Response in Livers of Bile Duct-Ligated Mice. Eur Surg Res. 2015;55:328-340 pubmed
    Wnt signaling is involved in the pathogenesis of liver fibrosis. Axin2 is a negative regulator of the canonical Wnt pathway by promoting β-catenin degradation...
  59. Liang J, Qin C, Yue H, He H, Bian Z. A novel initiation codon mutation of PAX9 in a family with oligodontia. Arch Oral Biol. 2016;61:144-8 pubmed publisher
    Recent studies have attributed non-syndromic tooth agenesis to mutations in several genes, including MSX1, PAX9, AXIN2, WNT10A and EDA...
  60. Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, et al. Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. Biochem Biophys Res Commun. 2016;470:356-361 pubmed publisher
    ..mRNA expression of essential signaling molecules involved in endochondral ossification (Pthrp, Ihh, and Axin2)...
  61. Haddaji Mastouri M, De Coster P, Zaghabani A, Trabelsi S, May Y, Saad A, et al. Characterization of a novel mutation in PAX9 gene in a family with non-syndromic dental agenesis. Arch Oral Biol. 2016;71:110-116 pubmed publisher
    ..for the eventual genetic cause of dental agenesis in this family we sequenced 4 genes; PAX9, WNT10A, MSX1 and AXIN2 using Sanger sequencing. Direct Screening analysis of PAX9 gene, revealed a novel mutation p.Asp200Serfs*13...
  62. Paluszczak J, Kleszcz R, Studzinska Sroka E, Krajka Kuzniak V. Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells. Mol Cell Biochem. 2018;441:109-124 pubmed publisher
    ..as a reference ?-catenin inhibitor, dose-dependently reduced the expression of the classical ?-catenin target gene-Axin2 in both cell lines...
  63. Muto Y, Maeda T, Suzuki K, Kato T, Watanabe F, Kamiyama H, et al. DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability. BMC Cancer. 2014;14:466 pubmed publisher
    ..b>AXIN2, which cooperates with APC and ?-catenin in Wnt signaling, had more methylation alterations in Group 2, and its ..
  64. Ma Q, Yang Y, Feng D, Zheng S, Meng R, Fa P, et al. MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells. Oncotarget. 2015;6:35851-65 pubmed publisher
    ..MAGI3 overexpression in glioma cells C6 suppressed expression of β-catenin target genes including Cyclin D1 and Axin2, whereas MAGI3 knockdown in glioma cells U373 and LN229 enhanced their expression...
  65. Hartmans E, Orian Rousseau V, Matzke Ogi A, Karrenbeld A, de Groot D, de Jong S, et al. Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. Theranostics. 2017;7:482-492 pubmed publisher
    ..We validated the protein expression of the top identified genes, AXIN2, CEMIP, CD44 and JUN, in sporadic adenoma patient samples via immunohistochemistry (IHC)...
  66. Dzama M, Nigmatullina L, Sayols S, Kreim N, Soshnikova N. Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cells. Dev Biol. 2017;432:258-264 pubmed publisher
    ..We further show that the early epithelial progenitors have different capacity to generate Lgr5+ ISC progenitors and Axin2+ early precursors display the highest potential.
  67. Zhang Y. Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling. Biochem Biophys Res Commun. 2017;488:679-684 pubmed publisher
    ..lines, Reishi significantly decreased the phosphorylation of LRP6 and suppressed Wnt3a-activated Wnt target gene Axin2 expression...
  68. Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. Oncogene. 2000;19:537-45 pubmed
    ..Taken together, these results suggest that GSK-3beta-dependent phosphorylation of APC can be modulated by beta-catenin and PP2A complexed with Axin. ..
  69. Danopoulos S, Krainock M, Toubat O, Thornton M, Grubbs B, Al Alam D. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1036-L1049 pubmed publisher
    ..Moreover, using the reporter lines TOPGAL and Axin2-LacZ, there was an evident decrease in canonical Wnt signaling in the explants treated with the Rac1 inhibitor...
  70. Nie X, Chen Y, Tan J, Dai Y, Mao W, Qin G, et al. MicroRNA-221-3p promotes pulmonary artery smooth muscle cells proliferation by targeting AXIN2 during pulmonary arterial hypertension. Vascul Pharmacol. 2019;116:24-35 pubmed publisher
    ..A previous study by our group revealed that decreased expression of a tumor suppressor-AXIN2 (Axis inhibition protein 2) was responsible for enhanced PASMC proliferation and suppressed apoptosis...
  71. Hughes T, Brady H. Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA. J Biol Chem. 2005;280:8581-8 pubmed
    b>Axin2 is a negative regulator of Wnt/beta-catenin signaling with roles in early development and tumor suppression. We find that axin2 expression is regulated at both transcriptional and translational levels...
  72. Pinarbasi E, Gunes E, Pinarbasi H, Donmez G, Silig Y. AXIN2 polymorphism and its association with prostate cancer in a Turkish population. Med Oncol. 2011;28:1373-8 pubmed publisher
    Polymorphism of AXIN2, a component of Wnt signaling, has been shown to play a role in tumorigenesis and dysregulated in cancer cells...
  73. Wu X, Spitz M, Lee J, Lippman S, Ye Y, Yang H, et al. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Cancer Prev Res (Phila). 2009;2:617-24 pubmed publisher
    ..Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes. ..
  74. Moreno Marín N, Barrasa E, Morales Hernández A, Paniagua B, Blanco Fernández G, Merino J, et al. Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis. Sci Rep. 2017;7:10420 pubmed publisher
    ..cells (SP) isolated from AhR-/- livers had increased β-catenin (β-Cat) signaling with overexpression of Axin2, Dkk1 and Cyclin D1...
  75. Hadjihannas M, Brückner M, Jerchow B, Birchmeier W, Dietmaier W, Behrens J. Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc Natl Acad Sci U S A. 2006;103:10747-52 pubmed
    ..APC that lead to Wnt/beta-catenin signaling activation and subsequent transcription of target genes, including conductin/AXIN2. Here we demonstrate that Wnt/beta-catenin signaling causes CIN via up-regulation of conductin...
  76. Liu H, Ding T, Zhan Y, Feng H. A Novel AXIN2 Missense Mutation Is Associated with Non-Syndromic Oligodontia. PLoS ONE. 2015;10:e0138221 pubmed publisher
    ..Numerous gene mutations have been association with oligodontia. In the present study, we identified a de novo AXIN2 missense mutation (c.314T>G) in a Chinese individual with non-syndromic oligodontia...
  77. Quaye L, Dafou D, Ramus S, Song H, Gentry Maharaj A, Maharaj A, et al. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. Hum Mol Genet. 2009;18:1869-78 pubmed publisher
  78. Bernkopf D, Hadjihannas M, Behrens J. Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling. J Cell Sci. 2015;128:33-9 pubmed publisher
    Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin...
  79. Rosales Reynoso M, Arredondo Valdez A, Wence Chávez L, Barros Núñez P, Gallegos Arreola M, Flores Martínez S, et al. AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients. Genet Test Mol Biomarkers. 2016;20:438-44 pubmed publisher
    The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients...
  80. Pérez Palma E, Andrade V, Caracci M, Bustos B, Villaman C, Medina M, et al. Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons. Neural Plast. 2016;2016:4672841 pubmed publisher
    ..of 170 differentially expressed genes, including known Wnt/β-catenin target genes such as Notum, Axin2, and Lef1, as well as novel potential candidates Fam84a, Stk32a, and Itga9...
  81. Hübner K, Grassme K, Rao J, Wenke N, Zimmer C, Korte L, et al. Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1. Dev Biol. 2017;430:142-155 pubmed publisher
    ..in narrow time windows as well as in spatially restricted domains, defined by Cre recombinase expression (Tg(axin2BAC:Venus-Pest)mu288; Tg(14TCF:loxP-STOP-loxP-dGFP)mu202)...
  82. Zhang Y, Chidiac R, Delisle C, Gratton J. Endothelial NO Synthase-Dependent S-Nitrosylation of ?-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a. Mol Cell Biol. 2017;37: pubmed publisher
    ..Interestingly, induction by Wnt3a of ?-catenin target genes, such as the axin2 gene, is repressed in an eNOS-dependent manner by vascular endothelial growth factor (VEGF)...
  83. Li J, Hu S, Wang L, Zhang X, Zhou X, Yang B, et al. Autophagy-dependent generation of Axin2+ cancer stem-like cells promotes hepatocarcinogenesis in liver cirrhosis. Oncogene. 2017;36:6725-6737 pubmed publisher
    ..the precise mechanism related to the origin of CSCs in liver cirrhosis and hepatocarcinogenesis, we labeled Axin2+ hepatic cells with EGFP in Axin2Cre;Rosa26EGFP transgenic rats, and then stratified clinical and rat liver ..
  84. Inkster B, Nichols T, Saemann P, Auer D, Holsboer F, Muglia P, et al. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. Neuroimage. 2010;53:908-17 pubmed publisher
    ..Our observations lend support to the hypothesis that polymorphisms in GSK3beta play a role in MDD susceptibility or expression, in part, by acting via the canonical Wnt signaling pathway and related substrates. ..
  85. Takahashi H, Suzuki Y, Nishimura J, Haraguchi N, Ohtsuka M, Miyazaki S, et al. Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base. Int J Oncol. 2016;48:115-22 pubmed publisher
    ..Flow cytometrically sorted CA9+ population showed increased mRNA level of a Wnt signaling factor AXIN2. In conclusion, these observations indicate that CA9 expression in normal crypt base cells has association with ..
  86. Jin L, Cao Y, Yu G, Wang J, Lin X, Ge L, et al. SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway. Cell Mol Biol Lett. 2017;22:14 pubmed publisher
    ..i> In addition, the target genes of the Wnt signaling pathway, AXIN2 (axin-related protein 2) and MMP7 (matrix metalloproteinase-7), were downregulated by SFRP2...
  87. Zhang M, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L, et al. TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis. Cancer Cell. 2015;27:547-60 pubmed publisher
    ..Here, we report a function of TGIF in Wnt signaling. TGIF associates with and diverts Axin1 and Axin2 from the β-catenin destruction complex, therefore allowing β-catenin accrual...
  88. Saito Y, Nakamura K, Miura D, Yunoki K, Miyoshi T, Yoshida M, et al. Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid. Nutrients. 2017;9: pubmed publisher
    ..Wnt3a or BIO, a GSK-3 inhibitor that activates β-catenin signaling, upregulated mRNA levels of AXIN2 and LEF1, Wnt signaling marker genes, and RUNX2 and BMP4, early osteogenic genes, in ..
  89. Frank D, Peng T, Zepp J, Snitow M, Vincent T, Penkala I, et al. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016;17:2312-2325 pubmed publisher
    ..emergence of a Wnt-responsive alveolar epithelial cell sublineage, which arises during alveologenesis, called the axin2+ alveolar type 2 cell, or AT2Axin2...
  90. Gong J, Jiang Y, Hao N, Zhu B, Li Y. Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk. Sci Rep. 2015;5:10111 pubmed publisher
    b>Axin2 is involved in the regulation of Wnt/β-catenin pathway and implicated in cancer development and progression...
  91. Thorvaldsen T, Pedersen N, Wenzel E, Stenmark H. Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and ?-Catenin Degradation. PLoS ONE. 2017;12:e0170508 pubmed publisher
    ..AXIN1 and AXIN2/Conductin, the rate-limiting factors for the stability and function of endogenous destruction complexes, are stabilized ..
  92. Major M, Camp N, Berndt J, Yi X, Goldenberg S, Hubbert C, et al. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science. 2007;316:1043-6 pubmed
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX. ..