Gene Symbol: AVPR1A
Description: arginine vasopressin receptor 1A
Alias: AVPR V1a, AVPR1, V1aR, vasopressin V1a receptor, SCCL vasopressin subtype 1a receptor, V1-vascular vasopressin receptor AVPR1A, V1a vasopressin receptor, antidiuretic hormone receptor 1A, vascular/hepatic-type arginine vasopressin receptor
Species: human
Products:     AVPR1A

Top Publications

  1. Hong K, Matsukawa R, Hirata Y, Hayasaka I, Murayama Y, Ito S, et al. Allele distribution and effect on reporter gene expression of vasopressin receptor gene (AVPR1a)-linked VNTR in primates. J Neural Transm (Vienna). 2009;116:535-8 pubmed publisher
    We surveyed repeat sequence in the 5' flanking region of primate arginine vasopressin receptor 1a gene (AVPR1a) which is important for social behavior in mammals. The amplified region was polymorphic in length in all species investigated...
  2. Levin R, Heresco Levy U, Bachner Melman R, Israel S, Shalev I, Ebstein R. Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. Psychoneuroendocrinology. 2009;34:901-8 pubmed publisher
    Arginine vasopressin and the arginine vasopressin 1a (AVPR1a) gene contribute to a range of social behaviors both in lower vertebrates and in humans...
  3. Walum H, Westberg L, Henningsson S, Neiderhiser J, Reiss D, Igl W, et al. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc Natl Acad Sci U S A. 2008;105:14153-6 pubmed publisher
    ..There is a strong association between a polymorphic repeat sequence in the 5' flanking region of the gene (avpr1a) encoding one of the AVP receptor subtypes (V1aR), and proneness for monogamous behavior in males of this species...
  4. Prichard Z, Mackinnon A, Jorm A, Easteal S. AVPR1A and OXTR polymorphisms are associated with sexual and reproductive behavioral phenotypes in humans. Mutation in brief no. 981. Online. Hum Mutat. 2007;28:1150 pubmed
    ..Associations were found between two polymorphisms within the AVPR1A gene and age of first sexual intercourse in men and women...
  5. McGraw L, Davis J, Thomas P, Young L, Thomas J. BAC-based sequencing of behaviorally-relevant genes in the prairie vole. PLoS ONE. 2012;7:e29345 pubmed publisher
    ..Finally, our sequencing data indicate that a duplication of the prairie vole AVPR1A locus likely originated from a recent segmental duplication spanning a minimum of 105 kb...
  6. Wassink T, Piven J, Vieland V, Pietila J, Goedken R, Folstein S, et al. Examination of AVPR1a as an autism susceptibility gene. Mol Psychiatry. 2004;9:968-72 pubmed
    ..The behavioral effects of AVP are mediated through the AVP receptor 1a (AVPR1a), making the AVPR1a gene a reasonable candidate for autism susceptibility...
  7. Bachner Melman R, Dina C, Zohar A, Constantini N, Lerer E, Hoch S, et al. AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. PLoS Genet. 2005;1:e42 pubmed
    ..serotonin transporter (SLC6A4: promoter region HTTLPR and intron 2 VNTR) and the arginine vasopressin receptor 1a (AVPR1a: promoter microsatellites RS1 and RS3)...
  8. Yirmiya N, Rosenberg C, Levi S, Salomon S, Shulman C, Nemanov L, et al. Association between the arginine vasopressin 1a receptor (AVPR1a) gene and autism in a family-based study: mediation by socialization skills. Mol Psychiatry. 2006;11:488-94 pubmed
    We examined three microsatellites in the arginine vasopressin 1a receptor gene (AVPR1a), two in the promoter region (RS1 and RS3) and an intronic microsatellite (AVR), for association with autism as well as scores on the Vineland Adaptive ..
  9. Knafo A, Israel S, Darvasi A, Bachner Melman R, Uzefovsky F, Cohen L, et al. Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA. Genes Brain Behav. 2008;7:266-75 pubmed
    ..candidate that may contribute to individual differences in altruistic behavior is the arginine vasopressin 1a (AVPR1a) receptor that in some mammals such as the vole has a profound impact on affiliative behaviors...

More Information

Publications123 found, 100 shown here

  1. Meyer Lindenberg A, Kolachana B, Gold B, Olsh A, Nicodemus K, Mattay V, et al. Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans. Mol Psychiatry. 2009;14:968-75 pubmed publisher
    ..Two microsatellite polymorphisms, RS1 and RS3, near the promoter of AVPR1A, encoding the receptor subtype most heavily implicated in behaviour regulation, have been linked to autism and ..
  2. Yang S, Cho S, Yoo H, Cho I, Park M, Kim B, et al. Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders. Neurosci Lett. 2010;479:197-200 pubmed publisher
    To determine the association between arginine vasopressin receptor 1A gene (AVPR1A) and autism spectrum disorders (ASDs), we examined 3 single nucleotide polymorphisms (SNPs), namely, rs7294536, rs3759292, and rs10877969, in the promoter ..
  3. Avinun R, Israel S, Shalev I, Gritsenko I, Bornstein G, Ebstein R, et al. AVPR1A variant associated with preschoolers' lower altruistic behavior. PLoS ONE. 2011;6:e25274 pubmed publisher
    ..However, previous findings concerning adults pointed at the arginine vasopressin receptor 1A (AVPR1A) gene as a possible candidate...
  4. Avinun R, Ebstein R, Knafo A. Human maternal behaviour is associated with arginine vasopressin receptor 1A gene. Biol Lett. 2012;8:894-6 pubmed publisher
    ..focuses on maternal behaviour and on an allele at the RS3 promoter region of the arginine vasopressin receptor 1A (AVPR1A) gene, previously associated with autism and with higher amygdala activation in a face-matching task...
  5. Thibonnier M, Graves M, Wagner M, Auzan C, Clauser E, Willard H. Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene. Genomics. 1996;31:327-34 pubmed
    We recently reported the structure and functional expression of a human V1a vasopressin receptor (V1aR) cDNA isolated from human liver cDNA libraries...
  6. Thibonnier M, Graves M, Wagner M, Chatelain N, Soubrier F, Corvol P, et al. Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension. J Mol Cell Cardiol. 2000;32:557-64 pubmed
    ..characteristics, tissue expression, chromosomal localization, and regional mapping of the human V(1)R gene, AVPR1A. To test whether the V(1)R is a marker for human essential hypertension, we sequenced the human AVPR1A gene and ..
  7. Kim S, Young L, Gonen D, Veenstra Vanderweele J, Courchesne R, Courchesne E, et al. Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. Mol Psychiatry. 2002;7:503-7 pubmed
    ..been shown to increase a range of social behaviors, including affiliation and attachment, via the V(1a) receptor (AVPR1A) in the brain...
  8. Israel S, Lerer E, Shalev I, Uzefovsky F, Reibold M, Bachner Melman R, et al. Molecular genetic studies of the arginine vasopressin 1a receptor (AVPR1a) and the oxytocin receptor (OXTR) in human behaviour: from autism to altruism with some notes in between. Prog Brain Res. 2008;170:435-49 pubmed publisher
    ..Recent molecular genetic studies of the human arginine vasopressin 1a (AVPR1a) and oxytocin (OXTR) receptors have strengthened the evidence regarding the role of these two neuropeptides in a ..
  9. Ukkola L, Onkamo P, Raijas P, Karma K, Jarvela I. Musical aptitude is associated with AVPR1A-haplotypes. PLoS ONE. 2009;4:e5534 pubmed publisher
    ..of music in human evolution and communication we analyzed polymorphisms of the arginine vasopressin receptor 1A (AVPR1A), serotonin transporter (SLC6A4), catecol-O-methyltranferase (COMT), dopamin receptor D2 (DRD2) and tyrosine ..
  10. Acevedo B, Poulin M, Brown L. Beyond romance: Neural and genetic correlates of altruism in pair-bonds. Behav Neurosci. 2019;133:18-31 pubmed publisher
    ..We investigated the neural and genetic (OXTR rs53576 and AVPR1a rs3) correlates of altruism (with the Agape scale) in newlywed pair-bonds...
  11. Leerkes E, Su J, Calkins S, Henrich V, Smolen A. Variation in mothers' arginine vasopressin receptor 1a and dopamine receptor D4 genes predicts maternal sensitivity via social cognition. Genes Brain Behav. 2017;16:233-240 pubmed publisher
    We examined the extent to which the arginine vasopressin receptor 1a (AVPR1a) and dopamine receptor D4 (DRD4) were related to sensitive maternal behavior directly or indirectly via maternal social cognition...
  12. Mohan S, Moffett R, Thomas K, Irwin N, Flatt P. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie. 2019;158:191-198 pubmed publisher
    ..In the present study, the presence of AVP receptors, namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2) was demonstrated in murine islets as well as rodent BRIN BD11 and human 1...
  13. Uzefovsky F, Shalev I, Israel S, Edelman S, Raz Y, Mankuta D, et al. Oxytocin receptor and vasopressin receptor 1a genes are respectively associated with emotional and cognitive empathy. Horm Behav. 2015;67:60-5 pubmed publisher
    ..Both the oxytocin receptor (OXTR) and the arginine vasopressin receptor 1a (AVPR1a) genes contribute to social cognition in both animals and humans and hence are prominent candidates for ..
  14. Namba T, Taniguchi M, Murata Y, Tong J, Wang Y, Okutani F, et al. Activation of arginine vasopressin receptor 1a facilitates the induction of long-term potentiation in the accessory olfactory bulb of male mice. Neurosci Lett. 2016;634:107-113 pubmed publisher
    ..AVP-paired LTP was blocked by the selective AVP receptor 1a (AVPR1a) antagonist, d(CH2)5[Tyr(Me)2]AVP (Manning compound), but not by the AVPR1b ..
  15. Bachner Melman R, Ebstein R. The role of oxytocin and vasopressin in emotional and social behaviors. Handb Clin Neurol. 2014;124:53-68 pubmed publisher
    ..The role of AVP and its receptor AVPR1a is described, with effects that often oppose and complement those of OT in determining social and emotional ..
  16. Tripathi A, Gaponenko V, Majetschak M. Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:243-8 pubmed publisher
    ..AR) subtypes (α1A/B/D, α2A/B/C), atypical chemokine receptor 3 (ACKR3), and vasopressin receptor 1A (AVPR1A) suffice these criteria...
  17. Slusarz M, Slusarz R, Ciarkowski J. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006;81:321-38 pubmed
    ..The internal water molecules involved in an intricate network of the hydrogen bonds inside the receptor cavity have been identified and their role in the stabilization of the agonist-bound state proposed. ..
  18. Mogil J, Sorge R, Lacroix Fralish M, Smith S, Fortin A, Sotocinal S, et al. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat Neurosci. 2011;14:1569-73 pubmed publisher
    Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin...
  19. Yap C, Wharfe M, Mark P, Waddell B, Smith J. Diurnal regulation of hypothalamic kisspeptin is disrupted during mouse pregnancy. J Endocrinol. 2016;229:307-18 pubmed publisher
    ..Anterior hypothalamic Avp mRNA expression exhibited no diurnal variation, but Avpr1a peaked at 12:00h during proestrus, possibly reflecting the circadian input from the suprachiasmatic nucleus to ..
  20. Graham B, Solomon N, Noe D, Keane B. Male prairie voles with different avpr1a microsatellite lengths do not differ in courtship behaviour. Behav Processes. 2016;128:53-7 pubmed publisher
    ..ochrogaster) showed significant social and sexual preferences for males with longer microsatellite DNA within the avpr1a gene encoding the vasopressin 1a receptor, as predicted if females select mates whose parental behaviour should ..
  21. Wood R, Knoll A, Levitt P. Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice. Physiol Behav. 2015;151:469-77 pubmed publisher
    ..social behavior, the present study utilized a genetic strategy to determine whether OXT and AVP receptors (OXTR, AVPR1a) are essential for female mice to demonstrate a conditioned social preference for ethanol...
  22. Zhang R, Zhang H, Han J, Han S. Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders. Neurosci Bull. 2017;33:238-246 pubmed publisher
    ..regarding associations between ASD and single-nucleotide variants of the human OXT-AVP pathway genes OXT, AVP, AVP receptor 1a (AVPR1a), OXT receptor (OXTR), the oxytocinase/vasopressinase (LNPEP), and ADP-ribosyl cyclase (CD38).
  23. Hawtin S. Pharmacological chaperone activity of SR49059 to functionally recover misfolded mutations of the vasopressin V1a receptor. J Biol Chem. 2006;281:14604-14 pubmed
    ..This work provides an excellent model to understand the mechanistic action of an important new class of drug that may have potential in the treatment of diseases caused by inherited mutations. ..
  24. Berrada K, Plesnicher C, Luo X, Thibonnier M. Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. J Biol Chem. 2000;275:27229-37 pubmed
    ..Thus, agonist stimulation of AVP/OT receptors leads to receptor subtype-specific interactions with GRK and PKC through specific motifs present in the C termini of the receptors. ..
  25. Freeman S, Palumbo M, Lawrence R, Smith A, Goodman M, Bales K. Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain. Transl Psychiatry. 2018;8:257 pubmed publisher
    ..This study quantified the density of OXTR and of the structurally related vasopressin 1a receptor (AVPR1a) in postmortem brain tissue from individuals with ASD and typically developing individuals...
  26. Pearce E, Wlodarski R, Machin A, Dunbar R. Associations between neurochemical receptor genes, 2D:4D, impulsivity and relationship quality. Biol Lett. 2018;14: pubmed publisher
    ..between 2D:4D and single-nucleotide polymorphisms (SNPs) in nine neurochemical receptor genes (AR, OXTR, AVPR1A, OPRM1, DRD1/2, ANKK1, 5HTR1A/2A), and secondly, whether digit ratios mediate the relationship between genetic ..
  27. Garcia A, Depena C, Yin W, Gore A. Testing the critical window of estradiol replacement on gene expression of vasopressin, oxytocin, and their receptors, in the hypothalamus of aging female rats. Mol Cell Endocrinol. 2016;419:102-12 pubmed publisher
    ..rat hypothalamus involved in social and affiliative behaviors that change with aging and/or estradiol (E2): Avp, Avpr1a, Oxt, Oxtr, and Esr2 in the paraventricular nucleus (PVN) and supraoptic nucleus (SON)...
  28. Okhovat M, Berrío A, Wallace G, Ophir A, Phelps S. Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain. Science. 2015;350:1371-4 pubmed publisher
    ..Among monogamous prairie voles, levels of vasopressin receptor (encoded by the gene avpr1a) in brain regions related to spatial memory predict male space use and sexual fidelity in the field...
  29. Albee L, Laporte H, Gao X, Eby J, Cheng Y, Nevins A, et al. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Open Biol. 2018;8: pubmed publisher
    ..and bioluminescence resonance energy transfer experiments suggested that recombinant and endogenous ACKR3 and AVPR1A interact on the cell surface...
  30. Landefeld C, Hodgkinson C, Spagnolo P, Marietta C, Shen P, Sun H, et al. Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Transl Psychiatry. 2018;8:72 pubmed publisher
    ..Here we use arginine vasopressin receptor 1a (AVPR1a) as an in-depth model of a methodologic limitation of GWAS: the functional genetic variation (in the form of short ..
  31. Young W, Kovacs K, Lolait S. The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin. Endocrinology. 1993;133:585-90 pubmed
    ..The vasopressin V1a receptor, whose activation results in phosphoinositol hydrolysis and mobilization of intracellular calcium, is ..
  32. Pagani J, Lee H, Young W. Postweaning, forebrain-specific perturbation of the oxytocin system impairs fear conditioning. Genes Brain Behav. 2011;10:710-9 pubmed publisher
    ..to examine associative learning in three lines of transgenic mice: mice that constitutively lack vasopressin 1a (Avpr1a(-/-)) or Oxt receptors (Oxtr(-/-)) and mice that have Oxt receptor loss restricted to the forebrain that begins ..
  33. Kii I, Hirahara Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, et al. Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ. Anal Biochem. 2018;549:174-183 pubmed publisher
    ..Atosiban acted as an antagonist of AVPR1a, as well as an agonist for AVPR1b, whereas PF13 antagonized OXTR more selectively than atosiban, as reported ..
  34. Fedoseeva L, Klimov L, Ershov N, Alexandrovich Y, Efimov V, Markel A, et al. Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats. BMC Genomics. 2016;17:989 pubmed publisher
    ..Four of them (Avpr1a, Hsd11b2, Agt, Ephx2) may provoke the hypertension development, and Mpo may contribute to insulin resistance and ..
  35. Freeman S, Inoue K, Smith A, Goodman M, Young L. The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta). Psychoneuroendocrinology. 2014;45:128-41 pubmed publisher
    ..of radioligands, which in primates bind to both OXTR and the structurally similar vasopressin 1a receptor (AVPR1A)...
  36. Salvatore J, Dick D. Genetic influences on conduct disorder. Neurosci Biobehav Rev. 2018;91:91-101 pubmed publisher
    ..A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotypes across independent studies; however, failures to replicate also exist...
  37. Inoue Murayama M, Yokoyama C, Yamanashi Y, Weiss A. Common marmoset (Callithrix jacchus) personality, subjective well-being, hair cortisol level and AVPR1a, OPRM1, and DAT genotypes. Sci Rep. 2018;8:10255 pubmed publisher
    ..on two questionnaires, hair samples were obtained to assay cortisol level and buccal swabs were used to assess AVPR1a, OPRM1 and DAT genotypes. Three personality domains-Dominance, Sociability, and Neuroticism-were identified...
  38. Buffone A, Poulin M. Empathy, target distress, and neurohormone genes interact to predict aggression for others-even without provocation. Pers Soc Psychol Bull. 2014;40:1406-22 pubmed publisher
    ..empathy combined with threat to a close other and individual differences in genes for the vasopressin receptor (AVPR1a rs3) and oxytocin receptor (OXTR rs53576) to predict self-reported aggression against a person who threatened a ..
  39. Staes N, Koski S, Helsen P, Fransen E, Eens M, Stevens J. Chimpanzee sociability is associated with vasopressin (Avpr1a) but not oxytocin receptor gene (OXTR) variation. Horm Behav. 2015;75:84-90 pubmed publisher
    ..Here we focus on variation in the vasopressin receptor gene 1a (Avpr1a) and oxytocin receptor gene (OXTR) and their effects on social personality traits in chimpanzees...
  40. Morley A, Narayanan M, Mines R, Molokhia A, Baxter S, Craig G, et al. AVPR1A and SLC6A4 polymorphisms in choral singers and non-musicians: a gene association study. PLoS ONE. 2012;7:e31763 pubmed publisher
    ..Those investigated previously include the variable number tandem repeats RS1, RS3 and AVR in the AVPR1A (arginine vasopressin receptor 1a) gene and STin2 in the SLC6A4 (solute carrier family 6 [neurotransmitter ..
  41. Daniels M, Brock G, Wittliff J. Clinical outcomes linked to expression of gene subsets for protein hormones and their cognate receptors from LCM-procured breast carcinoma cells. Breast Cancer Res Treat. 2017;161:245-258 pubmed publisher
    ..Four genes, POMC, CALCR, AVPR1A, and GH1, of this 10-gene signature were identified in a 6-gene molecular signature for ER- specimens...
  42. Kerbert A, Schaapman J, van der Reijden J, Amorós Navarro À, McCormick A, van Hoek B, et al. Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis. Eur J Gastroenterol Hepatol. 2017;29:535-538 pubmed publisher
    ..Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF. ..
  43. George S, Wallace M, Wu S, Moser M, Wright T, Farmer K, et al. Biopsychosocial influence on shoulder pain: risk subgroups translated across preclinical and clinical prospective cohorts. Pain. 2015;156:148-56 pubmed publisher
    ..DNA collected from saliva was genotyped for a priori selected genes involved with pain modulation (COMT and AVPR1A) and inflammation (IL1B and TNF/LTA)...
  44. Hasan K, Shoji M, Sugimoto K, Tsutaya S, Matsuda E, Kudo R, et al. Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese. J Hum Hypertens. 2007;21:825-7 pubmed
    We studied the association between four novel single nucleotide polymorphisms (SNPs) in the promoter region of V1aR gene and essential hypertension in 620 Japanese subjects (365 hypertensives and 255 healthy)...
  45. Roper J, O Carroll A, Young W, Lolait S. The vasopressin Avpr1b receptor: molecular and pharmacological studies. Stress. 2011;14:98-115 pubmed publisher
    ..The central distribution of Avpr1bs is far more restricted than that of the Avpr1a, the main Avp receptor subtype found in the brain...
  46. Scroggins S, Santillan D, Lund J, Sandgren J, Krotz L, Hamilton W, et al. Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. Clin Sci (Lond). 2018;132:419-436 pubmed publisher
    ..Mouse and human T cells expressed AVPR1a, AVPR1b, and AVPR2. The expression of AVPR1a was decreased in CD4+ T cells obtained from PreE-affected women...
  47. Freeman S, Ngo J, Singh B, Masnaghetti M, Bales K, Blevins J. Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain. Neuroscience. 2018;392:241-251 pubmed publisher
    ..OT suppresses food intake relative to control sites that express OXTR and (2) forebrain vasopressin 1a receptor (AVPR1a) density to evaluate the specificity of any OT effects...
  48. Ukkola Vuoti L, Oikkonen J, Onkamo P, Karma K, Raijas P, Jarvela I. Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music. J Hum Genet. 2011;56:324-9 pubmed publisher
    ..Three highly polymorphic microsatellite markers (RS3, RS1 and AVR) of the arginine vasopressin receptor 1A (AVPR1A) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish ..
  49. Bernhard R, Chaponis J, Siburian R, Gallagher P, Ransohoff K, Wikler D, et al. Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Soc Cogn Affect Neurosci. 2016;11:1872-1881 pubmed
    ..An association was likewise observed for rs1042615 of the arginine vasopressin receptor gene (AVPR1A)...
  50. Mahovetz L, Young L, Hopkins W. The influence of AVPR1A genotype on individual differences in behaviors during a mirror self-recognition task in chimpanzees (Pan troglodytes). Genes Brain Behav. 2016;15:445-52 pubmed publisher
    ..We examined whether vasopressin receptor gene (AVPR1A) polymorphisms are associated with MSR-related behaviors in chimpanzees since vasopressin has been implicated in ..
  51. Lesse A, Rether K, Gröger N, Braun K, Bock J. Chronic Postnatal Stress Induces Depressive-like Behavior in Male Mice and Programs second-Hit Stress-Induced Gene Expression Patterns of OxtR and AvpR1a in Adulthood. Mol Neurobiol. 2017;54:4813-4819 pubmed publisher
    ..induces depressive-like behavior and alters oxytocin receptor (OxtR) and arginine vasopressin receptor type 1a (AvpR1a) gene expression in the hippocampus (HC) of male mice and (2) if a second single stressor (forced swimming, FS) in ..
  52. Ivask M, Pajusalu S, Reimann E, Koks S. Hippocampus and Hypothalamus RNA-sequencing of WFS1-deficient Mice. Neuroscience. 2018;374:91-103 pubmed publisher
    ..05. Avpr1a and Avpr1b were significantly upregulated in the hypothalamus and hippocampus of Wfs1KO mice respectively...
  53. Roach K, Hershberger P, Rutherford J, Molokie R, Wang Z, Wilkie D. The AVPR1A Gene and Its Single Nucleotide Polymorphism rs10877969: A Literature Review of Associations with Health Conditions and Pain. Pain Manag Nurs. 2018;19:430-444 pubmed publisher
    ..One of the genes identified was the arginine vasopressin receptor 1A gene (AVPR1A) and its associated single-nucleotide polymorphism (SNP) rs10877969...
  54. Lucot K, Spangler M, Trenhaile M, Kachman S, Ciobanu D. Evaluation of reduced subsets of single nucleotide polymorphisms for the prediction of age at puberty in sows. Anim Genet. 2015;46:403-9 pubmed publisher
    ..5% could be obtained if genomic selection included both sexes compared to females alone. The pleiotropic role of major genes such as AVPR1A could be exploited in selection of both age at puberty and reproductive longevity.
  55. George S, Wu S, Wallace M, Moser M, Wright T, Farmer K, et al. Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve-Month Postoperative Pain and Disability Outcomes. Arthritis Care Res (Hoboken). 2016;68:1671-1680 pubmed publisher
    ..DNA was genotyped for a priori selected genes involved with pain modulation (ADRB2, OPRM1, AVPR1A, GCH1, and KCNS1) and inflammation (IL1B, TNF/LTA, and IL6)...
  56. Wilson V, Weiss A, Humle T, Morimura N, Udono T, Idani G, et al. Chimpanzee Personality and the Arginine Vasopressin Receptor 1A Genotype. Behav Genet. 2017;47:215-226 pubmed publisher
    Polymorphisms of the arginine vasopressin receptor 1a (AVPR1a) gene have been linked to various measures related to human social behavior, including sibling conflict and agreeableness...
  57. Oztan O, Jackson L, Libove R, Sumiyoshi R, Phillips J, Garner J, et al. Biomarker discovery for disease status and symptom severity in children with autism. Psychoneuroendocrinology. 2018;89:39-45 pubmed publisher
    ..has implicated the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP), and their receptors, OXTR and AVPR1A, in animal models...
  58. Liu J, Lou F, Lavebratt C, Forsell Y. Impact of Childhood Adversity and Vasopressin receptor 1a Variation on Social Interaction in Adulthood: A Cross-Sectional Study. PLoS ONE. 2015;10:e0136436 pubmed publisher
    Arginine vasopressin (AVP) plays a role in social behavior, through receptor AVPR1A. The promoter polymorphism AVPR1A RS3 has been associated with human social behaviors, and with acute response to stress...
  59. Latzman R, Young L, Hopkins W. Displacement behaviors in chimpanzees (Pan troglodytes): A neurogenomics investigation of the RDoC Negative Valence Systems domain. Psychophysiology. 2016;53:355-63 pubmed publisher
    ..a) examined the association between scratching and presence or absence of the RS3-containing DupB element in the AVPR1A 5' flanking region, (b) utilized voxel-based morphometry (VBM) to identify gray matter (GM) voxel clusters that ..
  60. Holmqvist Jämsen S, Johansson A, Westberg L, Santtila P, von der Pahlen B, Simberg S. Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene. J Speech Lang Hear Res. 2017;60:1843-1854 pubmed publisher
    ..to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single-nucleotide polymorphisms (SNPs) and vocal symptoms...
  61. Terrillon S, Barberis C, Bouvier M. Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. Proc Natl Acad Sci U S A. 2004;101:1548-53 pubmed
    b>V1a vasopressin receptor (V1aR) and V2 vasopressin receptor (V2R) present distinct mechanisms of agonist-promoted trafficking...
  62. Maher B, Vladimirov V, Latendresse S, Thiselton D, MCNAMEE R, Kang M, et al. The AVPR1A gene and substance use disorders: association, replication, and functional evidence. Biol Psychiatry. 2011;70:519-27 pubmed publisher
    ..Associations (p ? .0008) were detected with three SNPs in the arginine vasopressin 1A receptor gene, AVPR1A, with a gene-wise p value of 3 × 10(-5)...
  63. Tickerhoof M, Smith A. Vasopressinergic Neurocircuitry Regulating Social Attachment in a Monogamous Species. Front Endocrinol (Lausanne). 2017;8:265 pubmed publisher
    ..of the pair bond-related behaviors of the prairie vole, through activation of the AVP receptor subtype 1a (AVPR1a)...
  64. Yang S, Cho S, Yoo H, Cho I, Park M, Yoe J, et al. Family-based association study of microsatellites in the 5' flanking region of AVPR1A with autism spectrum disorder in the Korean population. Psychiatry Res. 2010;178:199-201 pubmed publisher
    ..between autism spectrum disorders (ASDs) and microsatellites (RS3 and RS1) in the 5' flanking region of AVPR1A in 148 Korean trios comprising children with ASDs...
  65. Stein C, Truitt B, Deng F, Ciesla A, Qiu F, Joseph P, et al. Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders. Psychiatr Genet. 2014;24:191-200 pubmed publisher
    ..central nervous system functioning: the dopamine D2 receptor (DRD2) gene, the arginine-vasopressin receptor 1a (AVPR1A) gene, and the microcephaly-associated protein gene (ASPM)...
  66. Grundwald N, Benítez D, Brunton P. Sex-Dependent Effects of Prenatal Stress on Social Memory in Rats: A Role for Differential Expression of Central Vasopressin-1a Receptors. J Neuroendocrinol. 2016;28: pubmed publisher
    ..further investigated the effects of PNS on the central expression of mRNA for oxytocin (Oxtr) and vasopressin-1a (Avpr1a) receptors...
  67. Lonn E, Koskela E, Mappes T, Mokkonen M, Sims A, Watts P. Balancing selection maintains polymorphisms at neurogenetic loci in field experiments. Proc Natl Acad Sci U S A. 2017;114:3690-3695 pubmed publisher
    ..Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and ..
  68. Hawtin S, Wesley V, Simms J, Argent C, Latif K, Wheatley M. The N-terminal juxtamembrane segment of the V1a vasopressin receptor provides two independent epitopes required for high-affinity agonist binding and signaling. Mol Endocrinol. 2005;19:2871-81 pubmed
    ..The V1a vasopressin receptor (V1aR) is a member of the neurohypophysial hormone subfamily of G protein-coupled receptors...
  69. Thibonnier M, Auzan C, Madhun Z, Wilkins P, Berti Mattera L, Clauser E. Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. J Biol Chem. 1994;269:3304-10 pubmed
    ..Thus, the human V1a AVP receptor belongs to the superfamily of seven-transmembrane segment receptors with a significant sequence identity with the other members of the AVP-oxytocin family of receptors. ..
  70. Hawtin S, Wesley V, Simms J, Parslow R, Miles A, McEwan K, et al. An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist. Eur J Biochem. 2003;270:4681-8 pubmed
    ..The V1a vasopressin receptor (V1aR) is a member of a family of related G-protein coupled receptors that are activated by ..
  71. Masuki S, Mori M, Tabara Y, Miki T, Sakurai A, Morikawa M, et al. Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. Hypertension. 2010;55:747-54 pubmed publisher
    We assessed whether single nucleotide polymorphism rs1042615 of the vasopressin V1a receptor altered the indices of lifestyle-related diseases in middle-aged and older people (mean+/-SD: 64+/-7 years), and, if so, whether it also altered ..
  72. Li X, Chan T, Myers V, Chowdhury I, Zhang X, Song J, et al. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through G?q-mediated cell signaling. Circulation. 2011;124:572-81 pubmed publisher
    ..Our results demonstrate a role for V1A-mediated signaling in the development of heart failure and support a role for V1A blockade in the treatment of patients with elevated levels of vasopressin. ..
  73. Bisceglia R, Jenkins J, Wigg K, O Connor T, Moran G, Barr C. Arginine vasopressin 1a receptor gene and maternal behavior: evidence of association and moderation. Genes Brain Behav. 2012;11:262-8 pubmed publisher
    ..associations among maternal sensitivity, mothers' early adversity and the Arginine Vasopressin 1a Receptor (AVPR1A) gene. Early adversity in mothers' background has been found to be associated with lower maternal sensitivity...
  74. Poulin M, Holman E, Buffone A. The neurogenetics of nice: receptor genes for oxytocin and vasopressin interact with threat to predict prosocial behavior. Psychol Sci. 2012;23:446-52 pubmed publisher
    ..We examined oxytocin receptor (OXTR) polymorphism rs53576, as well as vasopressin receptor 1a (AVPR1a) polymorphisms rs1 and rs3 in a national sample of U.S. residents (n = 348)...
  75. Feldman R, Vengrober A, Ebstein R. Affiliation buffers stress: cumulative genetic risk in oxytocin-vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children. Transl Psychiatry. 2014;4:e370 pubmed publisher
    ..risk factor was computed for each family member by summing five risk alleles across three genes (OXTR, CD38 and AVPR1a) previously associated with psychopathology, sociality and caregiving...
  76. Moons W, Way B, Taylor S. Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress. Emotion. 2014;14:562-72 pubmed publisher
    ..whereas oxytocin's sister peptide, arginine vasopressin (AVP) and polymorphisms in the vasopressin receptor gene (AVPR1A) have been independently associated with aggressive behavior...
  77. Wade M, Hoffmann T, Jenkins J. Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers' executive functioning. Brain Cogn. 2014;90:116-23 pubmed publisher
    ..systems in psychopathology, the current study hypothesized that variability in the AVP receptor 1a gene (AVPR1A) would be associated with EF in an epidemiological sample of 323 normally developing preschool-aged children...
  78. Phelps S, Okhovat M, Berrío A. Individual Differences in Social Behavior and Cortical Vasopressin Receptor: Genetics, Epigenetics, and Evolution. Front Neurosci. 2017;11:537 pubmed publisher
    ..Individual differences in RSC-V1aR are predicted by a set of linked single nucleotide polymorphisms within the avpr1a locus...
  79. Lazzari V, Zimmermann Peruzatto J, Agnes G, Becker R, de Moura A, Almeida S, et al. Hippocampal gene expression patterns in oxytocin male knockout mice are related to impaired social interaction. Behav Brain Res. 2017;: pubmed publisher
    ..In this study, we evaluated the expression levels of the OT receptor (Oxtr), AVP receptors 1a and 1b (Avpr1a; Avpr1b), dopamine receptor 2 (Drd2), and the estrogen receptors alpha and beta (Esr1; Esr2) genes in the ..
  80. North W, Fay M, Longo K, Du J. Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. Peptides. 1997;18:985-93 pubmed
    ..Both cell lines were shown to express an mRNA of 1.9 Kb for the vasopressin V1a receptor. RT-PCR, cloning, and DNA sequencing revealed the structure of the mRNA was identical for both cell lines,..
  81. North W, Fay M, Longo K, Du J. Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. Cancer Res. 1998;58:1866-71 pubmed
    ..It has been assumed that this peptide exercises its mitogenic influences through the vasopressin V1a receptor, and we have previously demonstrated that this receptor is expressed by classical and variant SCCL...
  82. Hasan K, Shoji M, Tsutaya S, Kudo R, Matsuda E, Saito J, et al. Study of V1a vasopressin receptor gene single nucleotide polymorphisms in platelet vasopressin responsiveness. J Clin Lab Anal. 2006;20:87-92 pubmed
    ..this study was to evaluate whether four single nucleotide polymorphisms (SNPs) in the promoter region of vasopressin V1a receptor gene (V1aR) could be used as genetic markers for divergent platelet aggregation response to AVP...
  83. Bachner Melman R, Lerer E, Zohar A, Kremer I, Elizur Y, Nemanov L, et al. Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4). Am J Med Genet B Neuropsychiatr Genet. 2007;144B:748-56 pubmed
    ..The insulin-like growth factor 2 (IGF2) and the arginine vasopressin 1a receptor (AVPR1a), previously shown to be associated with disordered eating, were also associated with CAPS scores...
  84. Vogel F, Wagner S, Baskaya O, Leuenberger B, Mobascher A, Dahmen N, et al. Variable number of tandem repeat polymorphisms of the arginine vasopressin receptor 1A gene and impulsive aggression in patients with borderline personality disorder. Psychiatr Genet. 2012;22:105-6 pubmed publisher
  85. Kazantseva A, Kutlumbetova Y, Malykh S, Lobaskova M, Khusnutdinova E. [Arginine-vasopressin receptor gene (AVPR1A, AVPR1B) polymorphisms and their relation to personality traits]. Genetika. 2014;50:341-52 pubmed
    ..GxE analysis revealed that the birth season modulated the involvement of the AVPR1A (rs11174811) gene marker in the variation of Persistence (TCI-125) in the total sample (P(FDR) = 0.012)...
  86. Kantojärvi K, Oikkonen J, Kotala I, Kallela J, Vanhala R, Onkamo P, et al. Association and Promoter Analysis of AVPR1A in Finnish Autism Families. Autism Res. 2015;8:634-9 pubmed publisher
    The arginine vasopressin receptor 1A gene (AVPR1A) is known to affect social communication and has been reported to associate with autism in several studies...
  87. Schaschl H, Huber S, Schaefer K, Windhager S, Wallner B, Fieder M. Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes. BMC Evol Biol. 2015;15:85 pubmed publisher
    ..specific receptors, which are encoded by the oxytocin receptor (OXTR) and arginine vasopressin receptor 1a genes (AVPR1A), respectively. In several species, polymorphisms in these genes have been linked to various behavioural traits...
  88. Wang J, Qin W, Liu F, Liu B, Zhou Y, Jiang T, et al. Sex-specific mediation effect of the right fusiform face area volume on the association between variants in repeat length of AVPR1A RS3 and altruistic behavior in healthy adults. Hum Brain Mapp. 2016;37:2700-9 pubmed publisher
    Microsatellite variants in the arginine vasopressin receptor 1A gene (AVPR1A) RS3 have been associated with normal social behaviors variation and autism spectrum disorders (ASDs) in a sex-specific manner...
  89. Nishitani S, Ikematsu K, Takamura T, Honda S, Yoshiura K, Shinohara K. Genetic variants in oxytocin receptor and arginine-vasopressin receptor 1A are associated with the neural correlates of maternal and paternal affection towards their child. Horm Behav. 2017;87:47-56 pubmed publisher
    ..affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A). Overall, 43 mothers and 41 fathers participated, and each parent's child smiling was video recorded...
  90. Procyshyn T, Hurd P, Crespi B. Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes. Autism Res. 2017;10:750-756 pubmed publisher
    Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk...
  91. Parreiras E Silva L, Vargas Pinilla P, Duarte D, Longo D, Espinoza Pardo G, Dulor Finkler A, et al. Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats. Proc Natl Acad Sci U S A. 2017;114:9044-9049 pubmed publisher
    ..Upon interaction with the AVPR1a, Pro8OXT and the common Leu8OXT yielded similar signaling profiles, being equally ..
  92. Nowacka Chmielewska M, Kasprowska Liśkiewicz D, Barski J, Obuchowicz E, Małecki A. The behavioral and molecular evaluation of effects of social instability stress as a model of stress-related disorders in adult female rats. Stress. 2017;20:549-561 pubmed publisher
    ..Hence, expression of POMC (pro-opiomelanocortin), AVPR1a (arginine vasopressin receptor), and OXTR (oxytocin receptor) significantly increased in the amygdala following ..