AURKC

Summary

Gene Symbol: AURKC
Description: aurora kinase C
Alias: AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C, aurora kinase C, ARK-3, aurora 3, aurora-related kinase 3, aurora/IPL1-related kinase 3, aurora/IPL1/EG2 protein 2, epididymis secretory protein Li 90, serine/threonine kinase 13 (aurora/IPL1-like), serine/threonine-protein kinase 13, serine/threonine-protein kinase aurora-C
Species: human
Products:     AURKC

Top Publications

  1. Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, et al. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem. 2004;279:47201-11 pubmed
    ..We therefore suggest that Aurora-C is a novel chromosomal passenger protein that cooperates with Aurora-B to regulate mitotic chromosome dynamics in mammalian cells. ..
  2. Chen H, Tang C, Chen C, Tang T. Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. J Biomed Sci. 2005;12:297-310 pubmed
    ..In order to study the potential role of Aurora-C, we examined the effects of a kinase-deficient (KD) mutant (AurC-KD) in HeLa Tet-Off cells under tetracycline control...
  3. Yan X, Cao L, Li Q, Wu Y, Zhang H, Saiyin H, et al. Aurora C is directly associated with Survivin and required for cytokinesis. Genes Cells. 2005;10:617-26 pubmed
    Much recent attention has been focused on Aurora C, the third member of the mammalian Aurora kinases family that plays significant roles in mitosis...
  4. Dutertre S, Hamard Peron E, Cremet J, Thomas Y, Prigent C. The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. Cell Cycle. 2005;4:1783-7 pubmed
  5. Zekri A, Lesan V, Ghaffari S, Tabrizi M, Modarressi M. Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines. Oncol Res. 2012;20:241-50 pubmed
    ..At DNA level, only Aurora-C showed gene amplification in breast cancer cell lines (p < 0.005). Here we provide evidence for the first time of Aurora-C overexpression and gene amplification. ..
  6. Kimura M, Matsuda Y, Yoshioka T, Okano Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J Biol Chem. 1999;274:7334-40 pubmed
    ..In the present study, a third human cDNA (AIK3) highly homologous to aurora/IPL1 was isolated, and the nucleotide sequence was determined...
  7. Katayama H, Brinkley W, Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003;22:451-64 pubmed
    ..Identification of these mechanisms offers the possibility of designing novel targeted therapies for cancer in the future. ..
  8. Khan J, Ezan F, Cremet J, Fautrel A, Gilot D, Lambert M, et al. Overexpression of active Aurora-C kinase results in cell transformation and tumour formation. PLoS ONE. 2011;6:e26512 pubmed publisher
    ..tumour formation when injected into nude mice, demonstrating the oncogenic activity of enzymatically active Aurora kinase C. Interestingly enough tumor aggressiveness was positively correlated with the quantity of active kinase, ..
  9. Dieterich K, Zouari R, Harbuz R, Vialard F, Martinez D, Bellayou H, et al. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. Hum Mol Genet. 2009;18:1301-9 pubmed publisher
    ..In a previous study, we demonstrated that a homozygous mutation (c.144delC) in the Aurora Kinase C (AURKC) gene led to the production of large-headed polyploid multi-flagellar spermatozoa, a primary ..

More Information

Publications83

  1. Yan X, Wu Y, Li Q, Cao L, Liu X, Saiyin H, et al. Cloning and characterization of a novel human Aurora C splicing variant. Biochem Biophys Res Commun. 2005;328:353-61 pubmed
    ..Despite the wealth of studies on human Aurora A and B, little is known about human Aurora C. Here we report a novel splicing variant of Aurora C, named as Aurora C-SV (Aurora C splicing variant), which ..
  2. Tseng T, Chen S, Hsu Y, Tang T. Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 1998;17:823-33 pubmed
    ..In this study, we describe two novel protein kinases, designated AIE1 (mouse) and AIE2 (human), which share high amino acid identities with the serine/threonine (S/T) kinase domain of yeast Ip11, fly ..
  3. Tsou J, Chang K, Chang Liao P, Yang S, Lee C, Chen Y, et al. Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. J Pathol. 2011;225:243-54 pubmed publisher
    Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear...
  4. Ben Khelifa M, Zouari R, Harbuz R, Halouani L, Arnoult C, Lunardi J, et al. A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis. Mol Hum Reprod. 2011;17:762-8 pubmed publisher
    ..We demonstrated previously that most cases were caused by a homozygous mutation (c.144delC) in the Aurora Kinase C gene (AURKC) leading to the absence or the production of a non-functional protein...
  5. Ben Khelifa M, Coutton C, Blum M, Abada F, Harbuz R, Zouari R, et al. Identification of a new recurrent aurora kinase C mutation in both European and African men with macrozoospermia. Hum Reprod. 2012;27:3337-46 pubmed publisher
    Can we identify new sequence variants in the aurora kinase C gene (AURKC) of patients with macrozoospermia and establish a genotype-phenotype correlation? We identified a new non-sense mutation, p...
  6. Dieterich K, Soto Rifo R, Faure A, Hennebicq S, Ben Amar B, Zahi M, et al. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Nat Genet. 2007;39:661-5 pubmed
    ..In all of these men, we identified a common region of homozygosity harboring the aurora kinase C gene (AURKC) with a single nucleotide deletion in the AURKC coding sequence...
  7. Sasai K, Katayama H, Stenoien D, Fujii S, Honda R, Kimura M, et al. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton. 2004;59:249-63 pubmed
    ..Finally, Aurora-C could rescue the Aurora-B silenced multinucleation phenotype, demonstrating that Aurora-C kinase function overlaps with and complements Aurora-B kinase function in mitosis. ..
  8. Bernard M, Sanseau P, Henry C, Couturier A, Prigent C. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. Genomics. 1998;53:406-9 pubmed
    This report describes the identification of a cDNA encoding STK13, a third human protein kinase related to the Drosophila Aurora and the budding yeast Ipl1 kinases...
  9. Slattery S, Mancini M, Brinkley B, Hall R. Aurora-C kinase supports mitotic progression in the absence of Aurora-B. Cell Cycle. 2009;8:2984-94 pubmed
    ..Wild-type, but not kinase-defective Aurora-C expression, was able to rescue these functions. Therefore, Aurora-C can perform the same essential functions as Aurora-B in mitosis. ..
  10. Avo Santos M, van de Werken C, de Vries M, Jahr H, Vromans M, Laven J, et al. A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. Hum Reprod. 2011;26:1868-81 pubmed publisher
    ..complex comprises the inner centromere protein (INCENP), survivin, borealin and Aurora B, or the meiotic kinase Aurora C. We analysed mRNA expression by quantitative RT-PCR of all CPC members in human oocytes, tripronuclear (3PN) ..
  11. Aguilar Morales I, Colín Ramírez E, Rivera Mancía S, Vallejo M, Vazquez Antona C. Performance of Waist-To-Height Ratio, Waist Circumference, and Body Mass Index in Discriminating Cardio-Metabolic Risk Factors in a Sample of School-Aged Mexican Children. Nutrients. 2018;10: pubmed publisher
    ..All the three adiposity indicators showed significant areas under the ROC curve (AURC) greater than 0...
  12. Hua J, Wan Y. Whole-exome sequencing identified a novel mutation of AURKC in a Chinese family with macrozoospermia. J Assist Reprod Genet. 2019;36:529-534 pubmed publisher
    ..from a consanguineous family allowed the identification of a novel homozygous missense variant in the AURKC gene (c.269G>A). Bioinformatics analysis also suggested this variant a pathogenic mutation...
  13. Nunes J, Furtado M, de Morais Nunes E, Sucupira M, Diaz R, Janini L. Modulation of epigenetic factors during the early stages of HIV-1 infection in CD4+ T cells in vitro. Virology. 2018;523:41-51 pubmed publisher
    ..The epigenetic targets aurora kinase B (AURKB), aurora kinase C (AURKC) and DNA methyltransferase 3B (DNMT3B), and the global DNA methylation profile are regulated during ..
  14. Diaz R, Golbourn B, Shekarforoush M, Smith C, Rutka J. Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. J Neurooncol. 2012;108:349-60 pubmed publisher
    ..AZD1152-HQPA also inhibited Aurora C activation loop threonine autophosphorylation at the effective antiproliferative concentrations in vitro...
  15. Mu X, Cui F, Zhang Z, Ding X. [Idiopathic teratozoospermia is not correlated with c.144delC polymorphism in the AURKC gene in Sichuan]. Zhonghua Nan Ke Xue. 2017;23:1069-1074 pubmed
    To investigate the association of a very common mutation of c.144delC in the aurora kinase C (AURKC) gene with idiopathic teratozoospermia in Chinese infertile men in Sichuan...
  16. Sharif B, Na J, Lykke Hartmann K, McLaughlin S, Laue E, Glover D, et al. The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. J Cell Sci. 2010;123:4292-300 pubmed publisher
    ..of one of the shared components of these complexes, INCENP, and of the variable kinase subunits, Aurora B or Aurora C. We show that either the depletion of INCENP or the combined inhibition of Aurora kinases B and C activates the ..
  17. Nguyen A, Drutovic D, Vazquez B, El Yakoubi W, Gentilello A, Malumbres M, et al. Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis. Curr Biol. 2018;28:3458-3468.e5 pubmed publisher
    ..kinase (AURK) homologs to help prevent aneuploidy (AURKA and AURKB), mammalian germ cells also require a third (AURKC) [2, 3]. AURKA is the spindle-pole-associated homolog, and AURKB/C are the chromosome-localized homologs...
  18. Rivera Mancía S, Colín Ramírez E, Cartas Rosado R, Infante O, Vargas Barrón J, Vallejo M. Indicators of accumulated fat are stronger associated with prehypertension compared with indicators of circulating fat: A cross-sectional study. Medicine (Baltimore). 2018;97:e11869 pubmed publisher
    ..The IOAFi had the greatest AURCs, followed by mixed and IOCFi; the AURCs for WC were the highest (AURC?=?0.688 and 0.666 for women and men, respectively)...
  19. Yang K, Li S, Chang C, Tang C, Lin Y, Lee S, et al. Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice. Mol Biol Cell. 2010;21:2371-83 pubmed publisher
    ..Microinjection of the kinase-deficient Aurora-C (AurC-KD) mRNA into mouse oocytes significantly inhibited Aurora-C activity and caused multiple defects, including ..
  20. de Braekeleer M, Nguyen M, Morel F, Perrin A. Genetic aspects of monomorphic teratozoospermia: a review. J Assist Reprod Genet. 2015;32:615-23 pubmed publisher
    ..Four mutations in the AURKC gene, a key player in meiosis and more particularly in spermatogenesis, have been found to be responsible for ..
  21. Gao K, Wang Z, Liu X, Dong Z, Shan W. [Genetic genes associated with oligospermia, asthenospermia and teratospermia: Advances in studies]. Zhonghua Nan Ke Xue. 2017;23:367-371 pubmed
    ..as CATSPER1, CRISP2, SEPT4, TCTE3, TEKT4, and DNAH1, with asthenospermia; and still others, such as DPY19L2 and AURKC, with teratospermia...
  22. Coutton C, Escoffier J, Martinez G, Arnoult C, Ray P. Teratozoospermia: spotlight on the main genetic actors in the human. Hum Reprod Update. 2015;21:455-85 pubmed publisher
    ..Homozygous mutations of aurora kinase C (AURKC) were first described to be responsible for most cases of macrozoospermia...
  23. Kawai K, Harada T, Ishikawa T, Sugiyama R, Kawamura T, Yoshida A, et al. Parental age and gene expression profiles in individual human blastocysts. Sci Rep. 2018;8:2380 pubmed publisher
    ..Among these genes, several are considered to be important for meiotic chromosomal segregation, such as PTTG1, AURKC, SMC1B and MEIKIN...
  24. Jung Y, Shin S, Yong Y, Jung H, Ahn S, Lee Y, et al. Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. Chem Biol Drug Des. 2015;85:574-85 pubmed publisher
    ..Quercetagetin binds to aurB, aurA, and aurC and prevents the active phosphorylation of all three aurora kinases...
  25. Cao F, Cheng J, Chen X, Li Y, Mao X. Development of an efficient genetic system in a gene cluster-rich endophytic fungus Calcarisporium arbuscula NRRL 3705. J Microbiol Methods. 2018;151:1-6 pubmed publisher
    ..arbuscula. By complementation of the monooxygenase gene aurC in ΔaurC mutant as a model, we showed that a strong but down-regulated promoter aurAp and three strong ..
  26. Balboula A, Stein P, Schultz R, Schindler K. RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse. Biol Reprod. 2015;92:105 pubmed publisher
    ..To our knowledge, these results are the first to identify RBBP4 as a regulator of histone deacetylation during oocyte maturation, and they provide evidence that deacetylation is required for bipolar spindle assembly through AURKC.
  27. Nguyen A, Gentilello A, Balboula A, Shrivastava V, Ohring J, Schindler K. Phosphorylation of threonine 3 on histone H3 by haspin kinase is required for meiosis I in mouse oocytes. J Cell Sci. 2014;127:5066-78 pubmed publisher
    ..Haspin and AURKC, an AURKB homolog, are enriched in germ cells, yet their significance in regulating MI is not fully understood...
  28. Fellmeth J, Gordon D, Robins C, Scott R, Treff N, Schindler K. Expression and characterization of three Aurora kinase C splice variants found in human oocytes. Mol Hum Reprod. 2015;21:633-44 pubmed publisher
    ..b>Aurora kinase C (AURKC) is a component of the chromosome passenger complex and is highly expressed in gametes...
  29. Kanhed A, Dash R, Parmar N, Das T, Giridhar R, Yadav M. Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model. Mol Divers. 2015;19:965-74 pubmed publisher
    Aurora kinases are sub-divided into Aurora A, Aurora B, and Aurora C kinases that are considered as prospective targets for a new class of anticancer drugs...
  30. Mason J, Frazer A, Horvath D, Pearce A, Avela J, Howatson G, et al. Adaptations in corticospinal excitability and inhibition are not spatially confined to the agonist muscle following strength training. Eur J Appl Physiol. 2017;117:1359-1371 pubmed publisher
    ..brachii and flexor carpi radialis were constructed and assessed by examining the area under the recruitment curve (AURC). Strength training resulted in a 29% (P < 0...
  31. Tang A, Gao K, Chu L, Zhang R, Yang J, Zheng J. Aurora kinases: novel therapy targets in cancers. Oncotarget. 2017;8:23937-23954 pubmed publisher
    Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation...
  32. Le Thi Thu H, Marrero Ponce Y, Casañola Martin G, Cardoso G, Chávez M, Garcia M, et al. A Comparative Study of Nonlinear Machine Learning for the "In Silico" Depiction of Tyrosinase Inhibitory Activity from Molecular Structure. Mol Inform. 2011;30:527-37 pubmed publisher
    ..The derived models show rather encouraging results with the areas under the Receiver Operating Characteristic (AURC) curve in the test set above 0.943 and 0.846 for the Data I and Data II, respectively...
  33. Woo Seo D, Yeop You S, Chung W, Cho D, Kim J, Su Oh J. Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis. Sci Rep. 2015;5:15431 pubmed publisher
    ..Although Zwint-1 knockdown did not affect Aurora C kinase activity, the meiotic defects following Zwint-1 knockdown were similar to those observed with ZM447439 ..
  34. Balboula A, Blengini C, Gentilello A, Takahashi M, Schindler K. Maternal RNA regulates Aurora C kinase during mouse oocyte maturation in a translation-independent fashion. Biol Reprod. 2017;96:1197-1209 pubmed publisher
    During oocyte meiotic maturation, Aurora kinase C (AURKC) is required to accomplish many critical functions including destabilizing erroneous kinetochore-microtubule (K-MT)attachments and regulating bipolar spindle assembly...
  35. Durlacher C, Li Z, Chen X, He Z, Zhou S. An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor. Clin Exp Pharmacol Physiol. 2016;43:585-601 pubmed publisher
    Human Aurora kinases, including Aurora kinase A (AURKA), B (AURKB), and C (AURKC), play an essential role in mitotic events such as monitoring of the mitotic checkpoint, creation of bipolar mitotic spindle and alignment of centrosomes on ..
  36. Guo X, Ni J, Dai X, Zhou T, Yang G, Xue J, et al. Biphasic regulation of spindle assembly checkpoint by low and high concentrations of resveratrol leads to the opposite effect on chromosomal instability. Mutat Res. 2018;825:19-30 pubmed publisher
    ..05). In conclusion, RSV exhibited a biphasic dose-dependent effect on CIN that was exerted via the regulation of mitotic fidelity through the SAC network. The health implications of these findings were summarized. ..
  37. Miyamoto T, Minase G, Okabe K, Ueda H, Sengoku K. Male infertility and its genetic causes. J Obstet Gynaecol Res. 2015;41:1501-5 pubmed publisher
    ..the azoospermia factor (AZF) region on the Y chromosome, as well as the autosomally located genes: SYKP3, KLHL10, AURKC and SPATA16. Non-obstructive azoospermia is the most severe form of azoospermia...
  38. Mobasheri M, Shirkoohi R, Zendehdel K, Jahanzad I, Talebi S, Afsharpad M, et al. Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines. Tumour Biol. 2015;36:8201-6 pubmed publisher
    ..In this context, we investigated the expression of two known cancer testis genes, Aurora kinase C (AURKC) and testis expressed 101 (TEX101), and one new candidate, deleted in azoospermia 1 (DAZ1), in six ..
  39. Tien A, Lin M, Su L, Hong Y, Cheng T, Lee Y, et al. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004;3:93-104 pubmed
    ..Together, these results justify the timely implementation of in silico biology in routine wet-lab studies and have also allowed the application of a new approach to the elucidation of protein function in the post-genomic era. ..
  40. Ghédir H, Gribaa M, Mamaî O, Ben Charfeddine I, Braham A, Amara A, et al. Macrozoospermia: screening for the homozygous c.144delC mutation in AURKC gene in infertile men and estimation of its heterozygosity frequency in the Tunisian population. J Assist Reprod Genet. 2015;32:1651-8 pubmed publisher
    ..The homozygous mutation (c.144delC) in aurora kinase C gene (AURKC) has been identified as the most frequent mutation causing macrozoospermia in North African ..
  41. Spengler D. The protein kinase Aurora C phosphorylates TRF2. Cell Cycle. 2007;6:2579-80 pubmed
  42. Fellmeth J, Ghanaim E, Schindler K. Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system. Hum Mol Genet. 2016;25:2698-2711 pubmed
    ..b>Aurora kinase C (AURKC) is essential for formation of euploid sperm in humans because mutations in AURKC are correlated with ..
  43. Clark A, Glanowski S, Nielsen R, Thomas P, Kejariwal A, Todd M, et al. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science. 2003;302:1960-3 pubmed
    ..In addition to suggesting adaptive physiological differences between chimps and humans, human-accelerated genes are significantly more likely to underlie major known Mendelian disorders. ..
  44. Baldini E, Arlot Bonnemains Y, Mottolese M, Sentinelli S, Antoniani B, Sorrenti S, et al. Deregulation of Aurora kinase gene expression in human testicular germ cell tumours. Andrologia. 2010;42:260-7 pubmed publisher
    ..In conclusion, we demonstrated that expression of Aurora kinases is deregulated in seminomas, suggesting that they may play a role in the progression of testicular cancers. ..
  45. Lin B, Wang Y, Chang Liao P, Lin Y, Yang S, Tsou J, et al. Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B. Cell Death Dis. 2014;5:e1106 pubmed publisher
    ..Thus, our results suggest that aberrantly expressed Aurora-C in somatic cancer cells may impair SAC by displacing the centromeric localization of CPCs. ..
  46. Li W, Wang P, Zhang B, Zhang J, Ming J, Xie W, et al. Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. Protein Cell. 2017;8:662-674 pubmed publisher
    ..Aurora kinase B (AurkB) is ubiquitously expressed while Aurora kinase C (AurkC) is specifically expressed in gametes and preimplantation embryos...
  47. Nguyen A, Marin D, Zhou A, Gentilello A, Smoak E, Cao Z, et al. Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy. Mol Hum Reprod. 2017;23:406-416 pubmed publisher
    Are single nucleotide variants (SNVs) in Aurora kinases B and C (AURKB, AURKC) associated with risk of aneuploid conception? Two SNVs were found in patients with extreme aneuploid concepti rates with respect to their age; one variant, ..
  48. Ray P, Toure A, Metzler Guillemain C, Mitchell M, Arnoult C, Coutton C. Genetic abnormalities leading to qualitative defects of sperm morphology or function. Clin Genet. 2017;91:217-232 pubmed publisher
    ..this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2...
  49. Mesic A, Markocic E, Rogar M, Juvan R, Hudler P, Komel R. Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility. Environ Mol Mutagen. 2017;58:701-711 pubmed publisher
    ..We investigated the association of Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora kinase C (AURKC), Polo-like kinase 1 (PLK1) and Budding uninhibited by benzimidazol 3, yeast (BUB3) gene polymorphisms ..
  50. Gabillard J, Ulisse S, Baldini E, Sorrenti S, Cremet J, Coccaro C, et al. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Biochem Biophys Res Commun. 2011;408:647-53 pubmed publisher
  51. Han E, Min J, Yoo S, Park S, Choe Y, Yun H, et al. A small-molecule inhibitor targeting the AURKC-I?B? interaction decreases transformed growth of MDA-MB-231 breast cancer cells. Oncotarget. 2017;8:69691-69708 pubmed publisher
    The Aurora kinases, Aurora A (AURKA), Aurora B (AURKB), and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) or meiosis (AURKC)...
  52. Afsharpad M, Nowroozi M, Mobasheri M, Ayati M, Nekoohesh L, Saffari M, et al. Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder. Pathol Oncol Res. 2019;25:191-199 pubmed publisher
    ..ACTL7A, AURKC, and CGB2 were testis-restricted/selective genes that indicated specific expression in cases in comparison to ..
  53. Nguyen A, Schindler K. Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation. Trends Genet. 2017;33:349-363 pubmed publisher
    ..While most mitotic cells express two AURK isoforms (AURKA and AURKB), mammalian germ cells also express a third, AURKC. Although much is known about the functions of the kinases in mitosis, less is known about how the three isoforms ..
  54. Carry J, Clerc F, Minoux H, Schio L, Mauger J, Nair A, et al. SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem. 2015;58:362-75 pubmed publisher
    ..We also provide insights into its mode of binding to its target proteins, which could explain its selectivity. ..
  55. Balboula A, Nguyen A, Gentilello A, Quartuccio S, Drutovic D, Solc P, et al. Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes. J Cell Sci. 2016;129:3648-3660 pubmed
    ..The kinase haspin (also known as GSG2) is required to regulate Aurora kinase C (AURKC) localization at chromosomes during meiosis I...
  56. Yan M, Wang C, He B, Yang M, Tong M, Long Z, et al. Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy. Med Res Rev. 2016;36:1036-1079 pubmed publisher
  57. Sasai K, Katayama H, Hawke D, Sen S. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS ONE. 2016;11:e0157305 pubmed publisher
    ..Elevated expression of Aurora-C in cancer cells alters the structural and functional characteristics of the Aurora-B-CPC leading to chromosomal instability. ..
  58. Goldenson B, Crispino J. The aurora kinases in cell cycle and leukemia. Oncogene. 2015;34:537-45 pubmed publisher
    The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC)...
  59. Arbitrario J, Belmont B, Evanchik M, Flanagan W, Fucini R, Hansen S, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010;65:707-17 pubmed publisher
    ..SNS-314 is a potent small-molecule inhibitor of Aurora kinases developed as a novel anti-cancer therapeutic agent for the treatment of diverse human malignancies. ..
  60. Nna E, Madukwe J, Egbujo E, Obiorah C, Okolie C, Echejoh G, et al. Gene expression of Aurora kinases in prostate cancer and nodular hyperplasia tissues. Med Princ Pract. 2013;22:138-43 pubmed publisher
    ..Aurora kinases were significantly overexpressed in BPH cases compared to PCa cases. At the transcript level, there was no significant differential expression in the kinases between PCa and BPH cases. ..
  61. Lukasiewicz K, Lingle W. Aurora A, centrosome structure, and the centrosome cycle. Environ Mol Mutagen. 2009;50:602-19 pubmed publisher
    ..Overexpression of aurora A leads to centrosome amplification and cellular transformation. The activity of aurora A is regulated by phosphorlyation and proteasomal degradation. ..
  62. Pereira H, Soares Lima S, De Faria P, Cardoso L, Seuanez H. RPS6KA4/MIR1237 and AURKC promoter regions are differentially methylated in Wilms' tumor. Front Biosci (Elite Ed). 2018;10:143-154 pubmed
    ..Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT...
  63. Yazarloo F, Shirkoohi R, Mobasheri M, Emami A, Modarressi M. Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern. Med Oncol. 2013;30:368 pubmed publisher
    ..To find new CTA genes in AML, we analyzed the expression pattern of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L using real-time quantitative PCR in 51 AMLs and 6 myelodysplastic syndrome cases in ..
  64. Hosseini S, Hashemzadeh S, Estiar M, Ebrahimzadeh R, Fakhree M, Yousefi B, et al. Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer. Clin Lab. 2015;61:475-80 pubmed
    ..05). In conclusion, the overexpression of Aurora-C and Survivin genes may play an important role in the development of colorectal cancer and may play a potential role in cancer therapy. ..
  65. el Kerch F, Lamzouri A, Laarabi F, Zahi M, Ben Amar B, Sefiani A. [Confirmation of the high prevalence in Morocco of the homozygous mutation c.144delC in the aurora kinase C gene (AURKC) in the teratozoospermia with large-headed spermatozoa]. J Gynecol Obstet Biol Reprod (Paris). 2011;40:329-33 pubmed publisher
    To confirm the recurrent character of the mutation c.144delC in the aurora kinase C (AURKC) gene in Morocco and determine the indication and the interest of the research of this anomaly. We looked for the mutation c...
  66. Eloualid A, Rouba H, Rhaissi H, Barakat A, Louanjli N, Bashamboo A, et al. Prevalence of the Aurora kinase C c.144delC mutation in infertile Moroccan men. Fertil Steril. 2014;101:1086-90 pubmed publisher
    To evaluate the carrier frequency of the pathogenic c.144delC mutation in AURKC gene and the contribution of this mutation in male infertility in a Moroccan population...
  67. Fernández Miranda G, Pérez de Castro I, Carmena M, Aguirre Portolés C, Ruchaud S, Fant X, et al. SUMOylation modulates the function of Aurora-B kinase. J Cell Sci. 2010;123:2823-33 pubmed publisher
    ..These data suggest that SUMOylation of Aurora B modulates its function, possibly by mediating the extraction of CPC complexes from chromosome arms during prometaphase. ..
  68. Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, et al. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol. 2015;36:8147-58 pubmed publisher
    b>AURKC, a member of the Aurora kinase gene family, is highly expressed in testis but is either moderately expressed or repressed in most somatic cells...
  69. Spengler D. Aurora-C-T191D is a hyperactive Aurora-C mutant. Cell Cycle. 2007;6:1803-4 pubmed
  70. Mason J, Frazer A, Horvath D, Pearce A, Avela J, Howatson G, et al. Ipsilateral corticomotor responses are confined to the homologous muscle following cross-education of muscular strength. Appl Physiol Nutr Metab. 2017;: pubmed publisher
    ..and non-homologous muscle were constructed and assessed by examining the area under the recruitment curve (AURC)...
  71. Quartuccio S, Dipali S, Schindler K. Haspin inhibition reveals functional differences of interchromatid axis-localized AURKB and AURKC. Mol Biol Cell. 2017;28:2233-2240 pubmed publisher
    ..of MI, bypass of the spindle assembly checkpoint (SAC), and loss of interchromatid axis-localized Aurora kinase C. Meiotic cells contain a second chromosomal passenger complex (CPC) population, with Aurora kinase B (AURKB) ..
  72. Carmignac V, Dupont J, Fierro R, Barberet J, Bruno C, Lieury N, et al. Diagnostic genetic screening for assisted reproductive technologies patients with macrozoospermia. Andrology. 2017;5:370-380 pubmed publisher
    ..So far, it has been associated with mutations only in the Aurora Kinase C gene (AURKC) in some cases...
  73. Mesic A, Rogar M, Hudler P, Juvan R, Komel R. Association of the AURKA and AURKC gene polymorphisms with an increased risk of gastric cancer. IUBMB Life. 2016;68:634-44 pubmed publisher
    ..We aimed to investigate the effects of Aurora kinase A (AURKA), Aurora kinase B (AURKB), and Aurora kinase C (AURKC) gene polymorphisms on GC risk in Slovenian population...
  74. Ounis L, Zoghmar A, Coutton C, Rouabah L, Hachemi M, Martinez D, et al. Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men. Asian J Androl. 2015;17:68-73 pubmed publisher
    ..Analyses of aurora kinase C (AURKC) and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, ..