AURKA

Summary

Gene Symbol: AURKA
Description: aurora kinase A
Alias: AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A, aurora 2, aurora/IPL1-like kinase, aurora/IPL1-related kinase 1, breast tumor-amplified kinase, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase aurora-A
Species: human
Products:     AURKA

Top Publications

  1. Guan Z, Wang X, Zhu X, Huang X, Xu J, Wang L, et al. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res. 2007;67:10436-44 pubmed
    ..Taken together, we showed that Aur-A kinase, a negative prognostic marker, promotes migration and reduces radiosensitivity in laryngeal cancer cells. ..
  2. Man C, Rosa J, Yip Y, Cheung A, Kwong Y, Doxsey S, et al. Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. Mol Biol Cell. 2008;19:2389-401 pubmed publisher
  3. Dutta Simmons J, Zhang Y, Gorgun G, Gatt M, Mani M, Hideshima T, et al. Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. Blood. 2009;114:2699-708 pubmed publisher
    ..in MM correlate with its transcriptional function, and we demonstrate regulation of a novel target gene, Aurora kinase A, implicating beta-catenin in G2/M regulation...
  4. Chou C, Yang N, Liu T, Tai S, Hsu D, Chen Y, et al. Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer. Cancer Res. 2013;73:953-66 pubmed publisher
    ..BMI1 mediates its diverse effects through upregulation of the mitotic kinase Aurora A, which is encoded by the AURKA gene. Two mechanisms were found to be responsible for BMI1-induced AURKA expression...
  5. Dogan I, Ekmekci A, Yurdakul A, Onen I, Ozturk C, Cirak M, et al. Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population. DNA Cell Biol. 2008;27:443-8 pubmed publisher
    ..05). A multivariable logistic regression analysis including patient characteristics, such as age and gender, did not change the results. ..
  6. Lei Y, Yan S, Ming De L, Na L, Rui Fa H. Prognostic significance of Aurora-A expression in human bladder cancer. Acta Histochem. 2011;113:514-8 pubmed publisher
    ..Our study suggests that overexpression of Aurora-A gene may play an important role in the progression of bladder cancer and that Aurora-A expression is an independent factor for predicting the prognosis of bladder cancer in patients. ..
  7. Wong J, Lerrigo R, Jang C, Fang G. Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol Biol Cell. 2008;19:2083-91 pubmed publisher
    ..We concluded that phosphorylation of HURP by Aurora A provides a regulatory mechanism for the control of spindle assembly and function. ..
  8. Goos J, Coupe V, Diosdado B, Delis van Diemen P, Karga C, Belien J, et al. Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis. Br J Cancer. 2013;109:2445-52 pubmed publisher
    ..We recently found that aurora kinase A (AURKA) drives 20q gain-associated tumour progression and is associated with disease recurrence...
  9. Zhang Y, Ni J, Huang Q, Ren W, Yu L, Zhao S. Identification of the auto-inhibitory domains of Aurora-A kinase. Biochem Biophys Res Commun. 2007;357:347-52 pubmed
    ..The non-Aurora box (aa 64-128) in the N-terminal negatively regulated the kinase activity of the C-terminal kinase domain by intramolecular interaction with aa 240-300 within the C-terminal. ..

More Information

Publications151 found, 100 shown here

  1. Lassmann S, Danciu M, Muller M, Weis R, Makowiec F, Schulte Mönting J, et al. Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers. Mod Pathol. 2009;22:1385-97 pubmed publisher
    ..Thus, sporadic colorectal cancers exhibit different mechanisms of aurora A regulation and this may impact the efficacy of aurora-targeted therapies. ..
  2. Sehdev V, Peng D, Soutto M, Washington M, Revetta F, Ecsedy J, et al. The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Mol Cancer Ther. 2012;11:763-74 pubmed publisher
    ..This study aimed to determine the levels of Aurora kinase A (AURKA) and the therapeutic potential of MLN8237, an investigational AURKA inhibitor, alone and in ..
  3. Wang W, Spitz M, Yang H, Lu C, Stewart D, Wu X. Genetic variants in cell cycle control pathway confer susceptibility to lung cancer. Clin Cancer Res. 2007;13:5974-81 pubmed
    ..27; 95% CI, 1.01-1.60). Compared with homozygous wild-types, the homozygous variant genotypes of STK15 F31I and CCND1 G870A were associated with a significantly altered lung cancer risk with ORs of 0.58 (95% CI, 0...
  4. Manfredi M, Ecsedy J, Chakravarty A, Silverman L, Zhang M, Hoar K, et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Clin Cancer Res. 2011;17:7614-24 pubmed publisher
    ..Alisertib is a selective and potent inhibitor of AAK. The novel methods of measuring Aurora A pathway inhibition and application of tumor imaging described here may be valuable for clinical evaluation of small-molecule inhibitors. ..
  5. Hutterer A, Berdnik D, Wirtz Peitz F, Zigman M, Schleiffer A, Knoblich J. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell. 2006;11:147-57 pubmed
    ..We propose a model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A. ..
  6. Ando Y, Yasuda S, Oceguera Yanez F, Narumiya S. Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells. Mol Biol Cell. 2007;18:3752-63 pubmed
    ..These results suggest that Rho GTPases function in G2/M transition of mammalian cells by mediating multiple signaling pathways converging to centrosomal activation of Aurora-A. ..
  7. Ice R, McLaughlin S, Livengood R, Culp M, Eddy E, Ivanov A, et al. NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors. Cancer Res. 2013;73:3168-80 pubmed publisher
    Aurora A kinase (AURKA) is overexpressed in 96% of human cancers and is considered an independent marker of poor prognosis...
  8. Sillars Hardebol A, Carvalho B, Tijssen M, Belien J, de Wit M, Delis van Diemen P, et al. TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. Gut. 2012;61:1568-75 pubmed
    ..The aim of this study was to identify genes located on the 20q amplicon that promote progression of colorectal adenoma to carcinoma...
  9. Hammerschmied C, Stoehr R, Walter B, Wieland W, Hartmann A, Blaszyk H, et al. Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma. Oncol Rep. 2007;17:3-7 pubmed
    ..b>STK15 is an important protein in control of the integrity of the mitotic spindle apparatus and genomic stability...
  10. Lim K, Brady D, Kashatus D, Ancrile B, Der C, Cox A, et al. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol. 2010;30:508-23 pubmed publisher
    ..Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA...
  11. Joukov V, De Nicolo A, Rodriguez A, Walter J, Livingston D. Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation. Proc Natl Acad Sci U S A. 2010;107:21022-7 pubmed publisher
    ..These events require the serine/threonine kinase, Aurora A (AurA), and the centrosomal protein of 192 kDa (Cep192)/spindle defective 2 (Spd-2), but the underlying mechanism remains ..
  12. Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, et al. Oncogenic role of nuclear accumulated Aurora-A. Mol Carcinog. 2009;48:810-20 pubmed publisher
    Aurora-A, also known as Aik, BTAK, or STK15, is a centrosomal serine/threonine protein kinase, which is proto-oncogenic and is overexpressed in a wide range of human cancers...
  13. Qin L, Tong T, Song Y, Xue L, Fan F, Zhan Q. Aurora-A interacts with Cyclin B1 and enhances its stability. Cancer Lett. 2009;275:77-85 pubmed publisher
    ..These results provide new insight into the mechanism of how deregulated Aurora-A contributes to genomic instability and carcinogenesis. ..
  14. Shang X, Burlingame S, Okcu M, Ge N, Russell H, Egler R, et al. Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma. Mol Cancer Ther. 2009;8:2461-9 pubmed publisher
    ..Overexpression of Aurora A is associated with disease progression in neuroblastoma. Inhibition of this kinase is a promising modality for neuroblastoma treatment. ..
  15. Wang L, Xiang J, Yan M, Zhang Y, Zhao Y, Yue C, et al. The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway. Cancer Res. 2010;70:9118-28 pubmed publisher
    ..Our findings indicate that activation of the cofilin-F-actin pathway contributes to tumor cell migration and metastasis enhanced by Aur-A, revealing a novel function for mitotic Aur-A kinase in tumor progression. ..
  16. Navaratne K, Weil R. The Aurora A F31I polymorphism is not a risk factor for glioblastoma. World Neurosurg. 2010;74:144-6 pubmed publisher
    ..The data obtained from this case-control study demonstrates that the Aurora A F31I polymorphism is not a significant risk for GBMs. ..
  17. Horwacik I, Durbas M, Boratyn E, Wegrzyn P, Rokita H. Targeting GD2 ganglioside and aurora A kinase as a dual strategy leading to cell death in cultures of human neuroblastoma cells. Cancer Lett. 2013;341:248-64 pubmed publisher
    ..It was shown that downregulation of aurora A kinase by the therapeutic antibody is associated with decreased levels of MYCN protein in cytoplasm, and induced expression of PHLDA1 and P53 proteins. ..
  18. Sardon T, Pache R, Stein A, Molina H, Vernos I, Aloy P. Uncovering new substrates for Aurora A kinase. EMBO Rep. 2010;11:977-84 pubmed publisher
    ..Our results provide a means by which to develop an understanding of Aurora A function and suggest unexpected roles for this kinase. ..
  19. Denzinger S, Stoehr R, Schwarz S, Eichenseher N, Brockhoff G, Obermann E, et al. Low level STK15 amplification in histologically benign urothelium of patients with bladder cancer adversely predicts patient outcome following cystectomy. Int J Oncol. 2007;31:793-802 pubmed
    The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to ..
  20. Bufo P, Sanguedolce F, Tortorella S, Cormio L, Carrieri G, Pannone G. Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms. Histol Histopathol. 2010;25:1371-7 pubmed publisher
    ..These findings indicate that Aurora A and B could be involved in the tumorigenesis of bladder cancer, thus providing a basis for a target therapy approach by using specific anti-mitotic agents. ..
  21. Yang F, Guo X, Yang G, Rosen D, Liu J. AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma. Mod Pathol. 2011;24:836-45 pubmed publisher
    b>Aurora kinase A (AURKA), a serine/threonine kinase, has been shown to regulate the cell cycle checkpoint and maintain genomic integrity. AURKA is overexpressed in various carcinomas...
  22. Zhang H, Chen X, Liu B, Zhou L. Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells. Mol Cell Biochem. 2011;357:95-106 pubmed publisher
    Overexpression of Aurora kinase A (AURKA) is frequently observed in various cancers, including laryngeal squamous cell carcinoma (LSCC)...
  23. Sourisseau T, Maniotis D, McCarthy A, Tang C, Lord C, Ashworth A, et al. Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. EMBO Mol Med. 2010;2:130-42 pubmed publisher
    ..These results identify a novel function of Aurora-A in modulating the response to DNA DSB that likely contributes to carcinogenesis and suggest a novel therapeutic approach to the treatment of cancers overexpressing this protein. ..
  24. Johnson E, Chang K, Ghosh S, Venkatesh C, Giger K, Low P, et al. LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy. J Cell Sci. 2012;125:1204-16 pubmed publisher
    ..Finally, Aurora-A-mediated upregulation of LIMK2 appears to be a common mechanism in many cancers. LIMK2 inhibition or ablation is therefore an alternative approach for modulating Aurora A deregulation in cancer. ..
  25. Kinzel D, Boldt K, Davis E, Burtscher I, Trumbach D, Diplas B, et al. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010;19:66-77 pubmed publisher
    ..Thus, the observation of a disassembly phenotype in vivo provides an entry point to understand and categorize ciliary disease. AUTHOR AUDIO: ..
  26. Comperat E, Camparo P, Haus R, Chartier Kastler E, Radenen B, Richard F, et al. Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms. Virchows Arch. 2007;450:419-24 pubmed
    ..03 in the NILGC group. Aurora-A is a more sensitive marker than MIB-1 to predict relapse in pTa bladder neoplasias. The combination of both markers seems to have a very powerful predictive value of recurrence (p<0.001). ..
  27. Yen C, Yeh C, Cheng C, Jung S, Huang S, Chang T, et al. Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker. Ann Surg Oncol. 2012;19:3491-9 pubmed publisher
    ..available from the Gene Expression Omnibus (GEO) and confirmed the prognostic influence of one selected gene, aurora kinase A (AURKA), in another cohort of 142 patients using immunohistochemistry (IHC)...
  28. Krystyniak A, Garcia Echeverria C, Prigent C, Ferrari S. Inhibition of Aurora A in response to DNA damage. Oncogene. 2006;25:338-48 pubmed
    ..Here, we provide evidence that Aurora A (AurA) was inhibited upon generation of double-strand breaks in DNA...
  29. Anderson K, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick R, et al. Binding of TPX2 to Aurora A alters substrate and inhibitor interactions. Biochemistry. 2007;46:10287-95 pubmed
    The Aurora kinases are a family of serine/threonine kinases involved in mitosis. The expression of AurA is ubiquitous and cell cycle regulated. It is overexpressed in many tumor types, including breast, colon, and ovarian...
  30. Plotnikova O, Pugacheva E, Golemis E. Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol. 2011;193:1021-32 pubmed publisher
    Most studies of Aurora A (AurA) describe it as a mitotic centrosomal kinase...
  31. Heron N, Anderson M, Blowers D, Breed J, Eden J, Green S, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006;16:1320-3 pubmed
    ..Co-crystallisation of one of these inhibitors with a fragment of Aurora A shows the importance of the benzamido group in achieving selectivity. ..
  32. Reiter R, Gais P, Jutting U, Steuer Vogt M, Pickhard A, Bink K, et al. Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma. Clin Cancer Res. 2006;12:5136-41 pubmed
    b>Aurora kinase A (AURKA/STK15/BTAK) encodes a serine/threonine kinase associated with chromosomal distribution and its up-regulation induces chromosomal instability, thereby leading to aneuploidy and cell transformation in several types ..
  33. Zhang X, Ems McClung S, Walczak C. Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. Mol Biol Cell. 2008;19:2752-65 pubmed publisher
    ..This is the first study that clearly defines a role for MCAK at the spindle poles as well as identifies another key Aurora A substrate that contributes to spindle bipolarity. ..
  34. Chen J, Li D, Wei C, Sen S, Killary A, Amos C, et al. Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. Clin Cancer Res. 2007;13:3100-4 pubmed
  35. Maxwell C, Benitez J, Gómez Baldó L, Osorio A, Bonifaci N, Fernández Ramires R, et al. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011;9:e1001199 pubmed publisher
    ..Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules...
  36. Cazales M, Schmitt E, Montembault E, Dozier C, Prigent C, Ducommun B. CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage. Cell Cycle. 2005;4:1233-8 pubmed
    ..CDC25B that is responsible for the activation of CDK1-cyclin B1 is regulated by phosphorylation. The STK15/Aurora-A kinase locally phosphorylates CDC25B on serine 353 at the centrosome during the G2/M transition...
  37. Fletcher O, Johnson N, Palles C, dos Santos Silva I, McCormack V, Whittaker J, et al. Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk. J Natl Cancer Inst. 2006;98:1014-8 pubmed
    b>STK15 may be a low-penetrance breast cancer susceptibility gene, and several reports suggest that women who are homozygous for the polymorphic variant F31I have an increased risk of breast cancer...
  38. Landen C, Lin Y, Immaneni A, Deavers M, Merritt W, Spannuth W, et al. Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients. Clin Cancer Res. 2007;13:4098-104 pubmed
    ..Aurora-A kinase is overexpressed by a substantial proportion of ovarian cancers and is associated with centrosome amplification and poor survival. It may be a useful prognostic marker and target in ovarian cancer. ..
  39. Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, et al. Suppression of polyploidy by the BRCA2 protein. Cancer Lett. 2007;257:65-72 pubmed
  40. Zhang W, Wang J, Liu S, Hua W, Xin X. Correlation between Aurora-A expression and the prognosis of cervical carcinoma patients. Acta Obstet Gynecol Scand. 2009;88:521-7 pubmed publisher
    ..Multivariate analysis showed that high Aurora-A mRNA expression was an independent prognostic factor (risk ratio: 2.88; p=0.005). Aurora-A might be used as a prognostic marker for cervical carcinoma patients. ..
  41. Mori D, Yano Y, Toyo oka K, Yoshida N, Yamada M, Muramatsu M, et al. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol. 2007;27:352-67 pubmed
    ..Our findings suggest that Aurora-A-mediated phosphorylation of NDEL1 is essential for centrosomal separation and centrosomal maturation and for mitotic entry. ..
  42. Nadler Y, Camp R, Schwartz C, Rimm D, Kluger H, Kluger Y. Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer. Clin Cancer Res. 2008;14:4455-62 pubmed publisher
    ..Prospective studies are needed to confirm the prognostic role of Aurora A as well as the predictive role of Aurora A expression in patients treated with Aurora A inhibitors. ..
  43. Zhao B, Smallwood A, Yang J, Koretke K, Nurse K, Calamari A, et al. Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci. 2008;17:1791-7 pubmed publisher
    ..We have solved the cocrystal structure of AurA/TPX2/VX-680 at 2.3 A resolution. In the crystal structure, VX-680 binds to the active conformation of AurA...
  44. Agnese V, Cabibi D, Calcara D, Terrasi M, Pantuso G, Fiorentino E, et al. Aurora-A overexpression as an early marker of reflux-related columnar mucosa and Barrett's oesophagus. Ann Oncol. 2007;18 Suppl 6:vi110-5 pubmed
    ..Further studies on a larger number of cases with a follow-up period are necessary in order to establish the risk of progression and the correct management of these subjects. ..
  45. Lee H, Zhu Y, Govindasamy K, Gopalan G. Downregulation of Aurora-A overrides estrogen-mediated growth and chemoresistance in breast cancer cells. Endocr Relat Cancer. 2008;15:765-75 pubmed publisher
    ..Nevertheless, Aurora-A inhibitors could be exploited to override the effects of estrogen on breast tumorigenesis and chemoresistance. ..
  46. Park H, Park W, Bondaruk J, Tanaka N, Katayama H, Lee S, et al. Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst. 2008;100:1401-11 pubmed publisher
    Chromosome missegregation and the resulting aneuploidy is a common change in neoplasia. The Aurora kinase A (AURKA) gene, which encodes a key regulator of mitosis, is frequently amplified and/or overexpressed in cancer cells, and the ..
  47. Lin Y, Su L, Yu C, Wong F, Yeh H, Chen S, et al. Gene expression profiles of the aurora family kinases. Gene Expr. 2006;13:15-26 pubmed
  48. Webb E, Rudd M, Houlston R. Case-control, kin-cohort and meta-analyses provide no support for STK15 F31I as a low penetrance colorectal cancer allele. Br J Cancer. 2006;95:1047-9 pubmed
    Recently, homozygosity for T91A single-nucleotide polymorphism (SNP) in the serine/threonine kinase (STK15) gene, which generates the substitution F31I has been proposed to increase the risk of a number of tumours including colorectal ..
  49. Ulisse S, Baldini E, Toller M, Delcros J, Guého A, Curcio F, et al. Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues. Endocr Relat Cancer. 2007;14:827-37 pubmed
    ..We propose that Aurora-A and TACC3 interaction is important to control the mitotic spindle organization required for proper chromosome segregation. ..
  50. Lucena Araujo A, de Oliveira F, Leite Cueva S, Dos Santos G, Falcao R, Rego E. High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. Leuk Res. 2011;35:260-4 pubmed publisher
    In the present study, we analyzed AURKA and AURKB gene expression in 70 acute myeloid leukemia (AML) patients...
  51. Zeng K, Bastos R, Barr F, Gruneberg U. Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol. 2010;191:1315-32 pubmed publisher
    ..These results demonstrate a hitherto unappreciated role for PP6 as the T-loop phosphatase regulating Aurora A activity during spindle formation and suggest the general importance of this form of regulation. ..
  52. Kozyreva V, McLaughlin S, Livengood R, Calkins R, Kelley L, Rajulapati A, et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014;12:681-93 pubmed publisher
    ..Mechanistically, it was shown that NEDD9 binds to and regulates acetylation of CTTN in an Aurora A kinase (AURKA)/HDAC6-dependent manner...
  53. Nishida N, Nagasaka T, Kashiwagi K, Boland C, Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther. 2007;6:525-33 pubmed
    ..Our data confirm involvement in the CDC4-cyclin E pathway of the development of the CIN phenotype in human CRC, and find that amplification of the Aurora-A is a common target for disruption of this pathway. ..
  54. Liu L, Guo C, Dammann R, Tommasi S, Pfeifer G. RASSF1A interacts with and activates the mitotic kinase Aurora-A. Oncogene. 2008;27:6175-86 pubmed publisher
    ..Inhibition of centrosome separation by RASSF1A overexpression is most likely a consequence of hyperstabilization of microtubules by this protein. ..
  55. Mendiola M, Barriuso J, Mariño Enríquez A, Redondo A, Domínguez Cáceres A, Hernández Cortés G, et al. Aurora kinases as prognostic biomarkers in ovarian carcinoma. Hum Pathol. 2009;40:631-8 pubmed publisher
    ..The amplification of AURKA gene by fluorescence in situ hybridization was also assessed. Overall, 58.8% and 85...
  56. Wang J, Yang S, Zhang H, Song Y, Zhang X, Qian H, et al. Aurora-A as an independent molecular prognostic marker in gastric cancer. Oncol Rep. 2011;26:23-32 pubmed publisher
  57. Kwon Y, Kim I, Wu D, Lu J, Stock W, Liu Y, et al. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012;10:834-44 pubmed publisher
    ..Our results establish a novel posttranslational regulatory network in which the Pten and Fbxw7 pathways appear to converge on the regulation of Aurora-A level. ..
  58. Inandıklıoğlu N, Yilmaz S, Demirhan O, Erdogan S, Tanyeli A. Chromosome imbalances and alterations of AURKA and MYCN genes in children with neuroblastoma. Asian Pac J Cancer Prev. 2012;13:5391-7 pubmed
    ..We aimed to investigate AURKA and MYCN gene rearrangements and the chromosomal aberrations (CAs) to determine the prognosis of neuroblastoma...
  59. Yamamoto S, Yamamoto Ibusuki M, Yamamoto Y, Fujiwara S, Iwase H. A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer. BMC Cancer. 2013;13:217 pubmed publisher
    ..Our data indicate that Aurora A gene expression is an effective tool, which defines both tumor proliferation potency and patient prognosis. ..
  60. Xia Z, Wei P, Zhang H, Ding Z, Yang L, Huang Z, et al. AURKA governs self-renewal capacity in glioma-initiating cells via stabilization/activation of ?-catenin/Wnt signaling. Mol Cancer Res. 2013;11:1101-11 pubmed publisher
    ..In this investigation, it was determined that aurora kinase A (AURKA) regulates the self-renewal and tumorigenicity of GICs by stabilizing ?-catenin...
  61. Borges K, Moreno D, Martinelli C, Antonini S, de Castro M, Tucci S, et al. Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis. Pediatr Blood Cancer. 2013;60:1809-16 pubmed publisher
    ..The mRNA expression levels of spindle checkpoint genes AURKA, AURKB, BUB, and BUBR1 were analyzed in 60 children with ACT by quantitative real time PCR...
  62. Tsai M, Zheng Y. Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly. Curr Biol. 2005;15:2156-63 pubmed
    The roles of the kinase Aurora A (AurA) in centrosome function and spindle assembly have been established in Drosophila, C. elegans, and Xenopus egg extracts ...
  63. Yang S, Zhou X, Zhu H, Quan L, Bai J, He J, et al. Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma. Oncol Rep. 2007;17:1083-8 pubmed
    Aurora-A/BTAK/STK15 gene which encodes a centrosome-associated kinase is located on chromosome 20q13.2, a highly amplified region in various human tumors...
  64. De Luca M, Brunetto L, Asteriti I, Giubettini M, Lavia P, Guarguaglini G. Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. Oncogene. 2008;27:6539-49 pubmed publisher
    ..These results indicate a novel function of Aurora-A, the regulation of ch-TOG and MCAK localization, and highlight a common pathway involving the three factors in control of spindle pole integrity. ..
  65. Staff S, Isola J, Jumppanen M, Tanner M. Aurora-A gene is frequently amplified in basal-like breast cancer. Oncol Rep. 2010;23:307-12 pubmed
    ..This study assesses the clinicopathological associations of AURKA gene amplification in clinical breast tumors and association of gene copy number with its mRNA and protein ..
  66. Zhang C, Fang Z, Xiong Y, Li J, Liu L, Li M, et al. Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression. Acta Biochim Biophys Sin (Shanghai). 2010;42:834-8 pubmed publisher
    The centrosome-associated kinase aurora A (AURKA) is involved in genetic instability and is over-expressed in several human carcinomas including colorectal cancer (CRC)...
  67. Giubettini M, Asteriti I, Scrofani J, De Luca M, Lindon C, Lavia P, et al. Control of Aurora-A stability through interaction with TPX2. J Cell Sci. 2011;124:113-22 pubmed publisher
    ..These results highlight a novel regulatory level impinging on Aurora-A and provide further evidence for the central role of TPX2 in regulation of Aurora-A. ..
  68. Wang X, Lu N, Niu B, Chen X, Xie J, Cheng N. Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells. Mol Cancer Res. 2012;10:588-96 pubmed publisher
    ..Taken together, these studies provide a molecular basis for promoting the role of Aurora-A in malignancy development of ESCC. ..
  69. Akkiz H, Bayram S, Bekar A, Akgöllü E, Ozdil B. Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma. J Viral Hepat. 2010;17:668-74 pubmed publisher
    ..003, odds ratio = 2.26, 95% confidence interval = 1.31-3.90 for FI + II genotypes vs FF genotype). Our results suggest for the first time that the Aurora A F31I polymorphism may be a genetic susceptibility factor for HCC. ..
  70. Chen C, Chuang H, Huang C, Fang F, Huang H, Tsai H, et al. Overexpression of Rap-1A indicates a poor prognosis for oral cavity squamous cell carcinoma and promotes tumor cell invasion via Aurora-A modulation. Am J Pathol. 2013;182:516-28 pubmed publisher
    ..Taken together, our results suggest that the Aurora-A/Rap-1A pathway is associated with survival, tumor progression, and metastasis of OCSCC patients. ..
  71. Molli P, Li D, Bagheri Yarmand R, Pakala S, Katayama H, Sen S, et al. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol. 2010;190:101-14 pubmed publisher
    ..Together, these findings reveal a new function for Arpc1b in centrosomal homeostasis. Arpc1b is both a physiological activator and substrate of Aurora A kinase and these interactions help to maintain mitotic integrity in mammalian cells...
  72. Lam A, Ong K, Ho Y. Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum Pathol. 2008;39:599-604 pubmed publisher
    ..These findings may be important to select patients to benefit for clinical trials of aurora kinase inhibitors. ..
  73. Dodson C, Bayliss R. Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic. J Biol Chem. 2012;287:1150-7 pubmed publisher
  74. Dotan E, Meropol N, Zhu F, Zambito F, Bove B, Cai K, et al. Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer. Br J Cancer. 2012;106:748-55 pubmed publisher
    Increased Aurora kinase A gene copy number (AURKA-CN) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to clinical outcome...
  75. Brockmann M, Poon E, Berry T, Carstensen A, Deubzer H, Rycak L, et al. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell. 2013;24:75-89 pubmed publisher
    ..We conclude that Aurora-A is an accessible target that makes destabilization of N-Myc a viable therapeutic strategy. ..
  76. Du J, Jablonski S, Yen T, Hannon G. Astrin regulates Aurora-A localization. Biochem Biophys Res Commun. 2008;370:213-9 pubmed publisher
    Alterations in the expression and activity of the centrosomal kinase, Aurora-A/STK15, affect genomic stability, disrupt the fidelity of centrosome duplication, and induce cellular transformation...
  77. Seki A, Coppinger J, Jang C, Yates J, Fang G. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science. 2008;320:1655-8 pubmed publisher
    ..Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle. ..
  78. Macurek L, Lindqvist A, Lim D, Lampson M, Klompmaker R, Freire R, et al. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature. 2008;455:119-23 pubmed publisher
    ..we show that in human cells PLK1 activation occurs several hours before entry into mitosis, and requires aurora A (AURKA, also known as STK6)-dependent phosphorylation of Thr 210...
  79. Jang C, Coppinger J, Seki A, Yates J, Fang G. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci. 2009;122:1334-41 pubmed publisher
  80. Coon T, Glasser J, Mallampalli R, Chen B. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Cell Cycle. 2012;11:721-9 pubmed publisher
    ..Interestingly, FBXL7 specifically interacts with Aurora A during mitosis but not in interphase, suggesting a regulatory role for FBXL7 in controlling Aurora A abundance during mitosis. ..
  81. Bibby R, Tang C, Faisal A, Drosopoulos K, Lubbe S, Houlston R, et al. A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J Biol Chem. 2009;284:33177-84 pubmed publisher
  82. Yao J, Yan M, Guan Z, Pan C, Xia L, Li C, et al. Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival. Mol Cancer. 2009;8:95 pubmed publisher
  83. Yang H, He L, Kruk P, Nicosia S, Cheng J. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. Int J Cancer. 2006;119:2304-12 pubmed
  84. Ogawa E, Takenaka K, Katakura H, Adachi M, Otake Y, Toda Y, et al. Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC). Ann Surg Oncol. 2008;15:547-54 pubmed
    Aurora-A, also known as STK15/BTAK, is a member of the protein serine/threonine kinase family, and experimental studies have revealed that Aurora-A plays critical roles in cell mitosis and in carcinogenesis...
  85. Ye Y, Yang H, Grossman H, Dinney C, Wu X, Gu J. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. Cancer. 2008;112:2467-74 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) from 7 cell cycle control genes, P53, P21, P27, CDK4, CDK6, CCND1, and STK15, were evaluated on bladder cancer risk in a case-control study of 696 bladder cancer cases and 629 healthy ..
  86. Wan X, Long Z, Yan M, Xu J, Xia L, Liu L, et al. Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis. 2008;29:1930-7 pubmed publisher
    ..Small chemical inhibitor VX-680 may offer as a promising molecular targeting agent in human NPC. ..
  87. Johnson E, Chang K, de Pablo Y, Ghosh S, Mehta R, Badve S, et al. PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer. J Cell Sci. 2011;124:2711-22 pubmed publisher
    ..Similar mutations are required for Aurora B, suggesting that this modified approach can be extended to other kinases that have hitherto not been amenable to this methodology. ..
  88. Tanenbaum M, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema R. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol. 2011;21:1356-65 pubmed publisher
    ..Together, these results uncover a novel role for Aurora kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells. ..
  89. Shao S, Wang Y, Jin S, Song Y, Wang X, Fan W, et al. Gadd45a interacts with aurora-A and inhibits its kinase activity. J Biol Chem. 2006;281:28943-50 pubmed
    ..These findings identify a novel mechanism for Gadd45a in the maintenance of centrosome stability and broaden understandings of p53- and BRCA1-regulated signaling pathways in maintaining genomic fidelity. ..
  90. Vidarsdottir L, Bodvarsdottir S, Hilmarsdottir H, Tryggvadottir L, Eyfjord J. Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations. Cancer Lett. 2007;250:206-12 pubmed
    ..9 BRCA1 and 98 BRCA2 mutation carriers, and 653 mutation-negative unaffected controls were genotyped for the AURKA 91T -->A polymorphism...
  91. Venoux M, Basbous J, Berthenet C, Prigent C, Fernandez A, Lamb N, et al. ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Hum Mol Genet. 2008;17:215-24 pubmed
    ..These kinases have been implicated in tumorigenesis. Aurora-A (AurA), in particular has been identified as a cancer-susceptibility gene, is overexpressed in a number of tumors and is ..
  92. Ricketts C, Zeegers M, Lubinski J, Maher E. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. PLoS ONE. 2009;4:e6037 pubmed publisher
    ..hypothesis for functional polymorphisms in CDH1 (rs16260), IGFBP3 (rs2854744), MMP1 (rs1799750), MMP3 (rs679620), STK15 (rs2273535) and VEGF (rs1570360)...