AUF1

Summary

Gene Symbol: AUF1
Description: heterogeneous nuclear ribonucleoprotein D
Alias: AUF1, AUF1A, HNRPD, P37, hnRNPD0, heterogeneous nuclear ribonucleoprotein D0, ARE-binding protein AUFI, type A, AU-rich element RNA binding protein 1, 37kDa, hnRNP D0
Species: human
Products:     AUF1

Top Publications

  1. Kiledjian M, DeMaria C, Brewer G, Novick K. Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol Cell Biol. 1997;17:4870-6 pubmed
    ..This protein is a member of the previously identified A+U-rich (ARE) binding/degradation factor (AUF1) family of proteins, which are also known as the heterogeneous nuclear RNP (hnRNP) D proteins...
  2. Wang Z, Day N, Trifillis P, Kiledjian M. An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro. Mol Cell Biol. 1999;19:4552-60 pubmed
    ..Therefore, the alpha-complex is an mRNA stability complex in vitro which could function at least in part by interacting with PABP. ..
  3. Knapinska A, Gratacós F, Krause C, Hernandez K, Jensen A, Bradley J, et al. Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation. Mol Cell Biol. 2011;31:1419-31 pubmed publisher
    b>AUF1 is an AU-rich element (ARE)-binding protein that recruits translation initiation factors, molecular chaperones, and mRNA degradation enzymes to the ARE for mRNA destruction...
  4. Lee N, Pimienta G, Steitz J. AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virus. RNA. 2012;18:2073-82 pubmed publisher
    ..stable isotope labeling of amino acids in cell culture (SILAC) and analysis by mass spectrometry, we identified AUF1 (AU-rich element binding factor 1)/hnRNP D (heterogeneous nuclear ribonucleoprotein D) as an interacting protein of ..
  5. Dempsey L, Li M, DePace A, Bray Ward P, Maizels N. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. Genomics. 1998;49:378-84 pubmed
    ..This very high level of conservation suggests a critical function for hnRNP D. Sequence analysis of the human HNRPD gene shows that the protein is encoded by eight exons and that two additional exons specify sequences in the 3' ..
  6. Laroia G, Cuesta R, Brewer G, Schneider R. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science. 1999;284:499-502 pubmed
    ..Rapid decay involves AU-rich binding protein AUF1, which complexes with heat shock proteins hsc70-hsp70, translation initiation factor eIF4G, and poly(A) binding ..
  7. Laroia G, Schneider R. Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms. Nucleic Acids Res. 2002;30:3052-8 pubmed
    ..3' non-coding region (3' NCR) of short-lived cytokine mRNAs binds several regulatory proteins, including hnRNP D/AUF1, which comprises four isoforms of 37, 40, 42 and 45 kDa...
  8. Wilson G, Lu J, Sutphen K, Suarez Y, Sinha S, Brewer B, et al. Phosphorylation of p40AUF1 regulates binding to A + U-rich mRNA-destabilizing elements and protein-induced changes in ribonucleoprotein structure. J Biol Chem. 2003;278:33039-48 pubmed
    ..These data indicate that selective AUF1 phosphorylation may regulate ARE-directed mRNA turnover by remodeling local RNA structures, thus potentially ..
  9. Wilson G, Lu J, Sutphen K, Sun Y, Huynh Y, Brewer G. Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1. J Biol Chem. 2003;278:33029-38 pubmed
    ..cytoplasmic complexes that bind AREs, including complexes containing the ARE-specific, mRNA-destabilizing factor, AUF1. Analyses of AUF1 from control and TPA-treated cells indicated that post-translational modifications of the major ..

More Information

Publications148 found, 100 shown here

  1. Lu J, Schneider R. Tissue distribution of AU-rich mRNA-binding proteins involved in regulation of mRNA decay. J Biol Chem. 2004;279:12974-9 pubmed
    ..b>AUF1 protein, a negative regulator of ARE mRNA stability, displayed strong expression in thymus and spleen cells within ..
  2. Lal A, Mazan Mamczarz K, Kawai T, Yang X, Martindale J, Gorospe M. Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J. 2004;23:3092-102 pubmed
    RNA-binding proteins HuR and AUF1 bind to many common AU-rich target mRNAs and exert opposing influence on target mRNA stability, but the functional interactions between HuR and AUF1 have not been systematically studied...
  3. Sinsimer K, Gratacós F, Knapinska A, Lu J, Krause C, Wierzbowski A, et al. Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay. Mol Cell Biol. 2008;28:5223-37 pubmed publisher
    ..The ARE-binding protein AUF1 forms a complex with cap-dependent translation initiation factors and heat shock proteins to attract the mRNA ..
  4. Paek K, Kim C, Park S, Kim J, Jang S. RNA-binding protein hnRNP D modulates internal ribosome entry site-dependent translation of hepatitis C virus RNA. J Virol. 2008;82:12082-93 pubmed publisher
    ..Moreover, knockdown of hnRNP D with siRNA significantly hampers infection by HCV. A potential role of hnRNP D in HCV proliferation is discussed. ..
  5. Rozovics J, Chase A, Cathcart A, Chou W, Gershon P, Palusa S, et al. Picornavirus modification of a host mRNA decay protein. MBio. 2012;3:e00431-12 pubmed publisher
    ..Here we describe experiments suggesting that AUF1, a host RNA binding protein involved in mRNA decay, plays a role in the infectious cycle of picornaviruses such as ..
  6. Wong J, Si X, Angeles A, Zhang J, Shi J, Fung G, et al. Cytoplasmic redistribution and cleavage of AUF1 during coxsackievirus infection enhance the stability of its viral genome. FASEB J. 2013;27:2777-87 pubmed publisher
    ..The adenosine-uridine (AU)-rich element RNA binding factor 1 (AUF1) is an integral component in the regulation of gene expression...
  7. Zhang W, Wagner B, Ehrenman K, Schaefer A, DeMaria C, Crater D, et al. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol. 1993;13:7652-65 pubmed
    ..present work, we have purified the RNA-binding component of this mRNA degradation activity, which we refer to as AUF1. Using antisera specific for these polypeptides, we demonstrate that the 37- and 40-kDa polypeptides are ..
  8. Sommer S, Cui Y, Brewer G, Fuqua S. The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells. J Steroid Biochem Mol Biol. 2005;97:219-29 pubmed
    ..This down-regulatory effect maps to three adenine/uridine-rich elements (AREs) that bind to cellular HuR and AUF1 (hnRNP D), two ARE-binding proteins (ARE-BPs) implicated in accelerated mRNA degradation...
  9. He C, Schneider R. 14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay. EMBO J. 2006;25:3823-31 pubmed
    Short-lived cytokine mRNAs contain an AU-rich destabilizing element (ARE). AUF1 proteins bind the ARE, undergo shuttling, and promote cytoplasmic ARE-mRNA decay through a poorly understood mechanism...
  10. Liao B, Hu Y, Brewer G. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. Nat Struct Mol Biol. 2007;14:511-8 pubmed
    ..The ARE-binding protein AUF1 contributes to their degradation. We identified MYC proto-oncogene mRNA as a cellular AUF1 target...
  11. Zucconi B, Ballin J, Brewer B, Ross C, Huang J, Toth E, et al. Alternatively expressed domains of AU-rich element RNA-binding protein 1 (AUF1) regulate RNA-binding affinity, RNA-induced protein oligomerization, and the local conformation of bound RNA ligands. J Biol Chem. 2010;285:39127-39 pubmed publisher
    AU-rich element RNA-binding protein 1 (AUF1) binding to AU-rich elements (AREs) in the 3'-untranslated regions of mRNAs encoding many cytokines and other regulatory proteins modulates mRNA stability, thereby influencing protein expression...
  12. Gratacós F, Brewer G. The role of AUF1 in regulated mRNA decay. Wiley Interdiscip Rev RNA. 2010;1:457-73 pubmed publisher
    ..ARE/poly(U)-binding/degradation factor 1 (AUF1), one of the best-characterized AUBPs, binds to many ARE-mRNAs and assembles other factors necessary to recruit the ..
  13. Lund N, Milev M, Wong R, Sanmuganantham T, Woolaway K, Chabot B, et al. Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression. Nucleic Acids Res. 2012;40:3663-75 pubmed publisher
    ..had differential effects on HIV-1 Gag expression, p45 and p42 isoforms increased viral Gag synthesis while p40 and p37 suppressed it...
  14. Wagner B, DeMaria C, Sun Y, Wilson G, Brewer G. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics. 1998;48:195-202 pubmed
    ..Many A + U-rich elements are bound by the AUF1 family of RNA-binding proteins, which may target these mRNAs for rapid decay...
  15. Lu J, Bergman N, Sadri N, Schneider R. Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA. 2006;12:883-93 pubmed
    ..b>AUF1/hnRNP D, an ARE-binding protein family consisting of four isoforms, promotes rapid decay of ARE-mRNAs...
  16. Sarkar S, Sinsimer K, Foster R, Brewer G, Pestka S. AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes. J Interferon Cytokine Res. 2008;28:679-91 pubmed publisher
    ..The ARE-binding protein AUF1 binds the IL10 3'-UTR...
  17. Kakegawa T, Yoshida L, Takada M, Noguchi M, Yasukawa K, Takano Ohmuro H. Comparison of the effects of pachymic acid, moronic acid and hydrocortisone on the polysome loading of RNAs in lipopolysaccharide-treated THP-1 macrophages. J Nat Med. 2019;73:190-201 pubmed publisher
    ..The expression of ARE-binding protein HuR/ELAV-1 was increased by the 3 compounds, and AUF1/hnRNP D was decreased by pachymic acid...
  18. Schmidtke L, Schrick K, Saurin S, Käfer R, Gather F, Weinmann Menke J, et al. The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally. Biochem J. 2019;476:333-352 pubmed publisher
    ..regulatory function of KSRP in type III IFN expression also in vivo Besides KSRP the RNA-binding protein AUF1 (AU-rich element RNA-binding protein 1) also seems to be involved in the regulation of type III IFN mRNA expression. ..
  19. Díaz Muñoz M, Bell S, Turner M. Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo. PLoS ONE. 2015;10:e0116899 pubmed publisher
    ..assays and predictions using a bioinformatics approach show that several RBPs bind to the Bcl2 AREs, including AUF1 and HuR proteins...
  20. Li X, Tian G, Shen H, Liu J. Metabolic engineering of Escherichia coli to produce zeaxanthin. J Ind Microbiol Biotechnol. 2015;42:627-36 pubmed publisher
    ..coli BETA-1 containing pZSPBA-2(P37-crtZPAN) that produced higher amounts of zeaxanthin (11.95 ± 0...
  21. Fragkouli A, Koukouraki P, Vlachos I, Paraskevopoulou M, Hatzigeorgiou A, Doxakis E. Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP. Sci Rep. 2017;7:44507 pubmed publisher
    ..Our study provides new insights into the regulation of APP pre-mRNA processing, supports the role for nELAVLs as neuron-specific splicing regulators and reveals a novel function of AUF1 in alternative splicing.
  22. Helenius L, Puhakka A, Manner T, Pajulo O, Helenius I. Preoperative pregabalin has no effect on intraoperative neurophysiological monitoring in adolescents undergoing posterior spinal fusion for spinal deformities: a double-blind, randomized, placebo-controlled clinical trial. Eur Spine J. 2018;27:298-304 pubmed publisher
    ..no statistically significant differences between the study groups regarding the latency of bilateral SSEP (N32 and P37) and MEP latencies at any time point...
  23. Tolnay M, Juang Y, Tsokos G. Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. Biochem J. 2002;363:127-36 pubmed
  24. Singh A, Kan C, Shende V, Dong B, Liu J. A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression. J Lipid Res. 2014;55:1397-407 pubmed publisher
    ..Altogether, this work identifies a novel posttranscriptional regulatory mechanism by which dietary cholesterol inhibits liver LDLR expression via inducing HNRNPD to accelerate LDLR mRNA degradation. ..
  25. Bauer A, Podola L, Mann P, Missanga M, Haule A, Sudi L, et al. Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA Prime-Modified Vaccinia Virus Ankara Boost HIV-1 Vaccine Regimen. J Virol. 2017;91: pubmed publisher
    ..volunteers received three injections of the DNA-SMI vaccine encoding a subtype B and AB-recombinant Gagp37 and two vaccinations with MVA-CMDR encoding subtype A Gagp55 Gag-specific T-cell responses were ..
  26. Pan Y, Chen H, Kilberg M. Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. J Biol Chem. 2005;280:34609-16 pubmed
    ..Another RNA-binding protein, AUF1, regulates target mRNA molecules by enhancing their decay...
  27. Jeyaraj S, Dakhlallah D, Hill S, Lee B. HuR stabilizes vacuolar H+-translocating ATPase mRNA during cellular energy depletion. J Biol Chem. 2005;280:37957-64 pubmed
    ..These results indicate that AU-rich elements and associated proteins can play a role in regulation of even very stable mRNAs by protecting against loss during cellular stress. ..
  28. David P, Tanveer R, Port J. FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1. RNA. 2007;13:1453-68 pubmed
    ..Two ARE binding proteins, HuR and AUF1, are associated with mRNA stabilization and destabilization, respectively...
  29. Gao X, Dong H, Lin C, Sheng J, Zhang F, Su J, et al. Reduction of AUF1-mediated follistatin mRNA decay during glucose starvation protects cells from apoptosis. Nucleic Acids Res. 2014;42:10720-30 pubmed publisher
    ..The expression of FST was elevated after knocking down AUF1 and reduced when AUF1 was further expressed...
  30. Alspach E, Flanagan K, Luo X, Ruhland M, Huang H, Pazolli E, et al. p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov. 2014;4:716-29 pubmed publisher
    ..We find that the mitogen-activated protein kinase p38 (p38MAPK) controls AUF1 occupancy on SASP mRNAs and thus controls their stability...
  31. Kamina A, Williams N. Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP). PLoS ONE. 2017;12:e0177890 pubmed publisher
    ..In Trypanosoma brucei, our laboratory has identified two trypanosome-specific RNA binding proteins P34 and P37 that are involved in the maturation of the 60S subunit during ribosome biogenesis. These proteins are part of the T...
  32. Jiang J, Tang C, Ren J, Zhang C, Dong L, Zhu Z. Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities. Pediatr neonatol. 2018;59:154-160 pubmed publisher
    ..The ability of learning and memory was assessed using the Morris water maze at P37 and P97. The hippocampal volume was measured by magnetic resonance imaging (MRI) at P37 and P97...
  33. Duan H, Qu L, Shou C. Mycoplasma hyorhinis induces epithelial-mesenchymal transition in gastric cancer cell MGC803 via TLR4-NF-κB signaling. Cancer Lett. 2014;354:447-54 pubmed publisher
    ..Furthermore, we found that TLR4 associated with p37, a membrane protein of M. hyorhinis. Knock-down or inhibition of TLR4 antagonized M...
  34. Alghamdi R, O Reilly P, Lu C, Gomes J, Lagace T, Basak A. LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation. Eur J Med Chem. 2015;92:890-907 pubmed publisher
    ..The effects were particularly significant with peptides P36, P37, P46 and P47...
  35. Boice M, Salloum D, Mourcin F, Sanghvi V, Amin R, Oricchio E, et al. Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells. Cell. 2016;167:405-418.e13 pubmed publisher
    ..Accordingly, administration of the HVEM ectodomain protein (solHVEM(P37-V202)) binds BTLA and restores tumor suppression...
  36. Wang G, Harnod T, Chiu T, Chen K. Effect of an Anterior Cingulotomy on Pain, Cognition, and Sensory Pathways. World Neurosurg. 2017;102:593-597 pubmed publisher
    ..The latencies of peaks P20 and P37 of the somatosensory evoked potential (SSEP) conductive time were used to evaluate the intactness of the ..
  37. Li X, Tian Z, Jin H, Xu J, Hua X, Yan H, et al. Decreased c-Myc mRNA Stability via the MicroRNA 141-3p/AUF1 Axis Is Crucial for p63α Inhibition of Cyclin D1 Gene Transcription and Bladder Cancer Cell Tumorigenicity. Mol Cell Biol. 2018;38: pubmed publisher
    ..directly releases its inhibition of 3' untranslated region (UTR) activity of AU-rich element RNA-binding factor 1 (AUF1) mRNA, thereby increasing AUF1 protein translation and further resulting in degradation of c-Myc mRNA, which, in ..
  38. Nagata T, Kurihara Y, Matsuda G, Saeki J, Kohno T, Yanagida Y, et al. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. J Mol Biol. 1999;287:221-37 pubmed
    ..It was also found that RBD1 has the ability to inhibit the formation of the quadruplex structure. ..
  39. Varlinskaya E, Truxell E, Spear L. Sex differences in sensitivity to the social consequences of acute ethanol and social drinking during adolescence. Behav Brain Res. 2015;282:6-13 pubmed publisher
    ..Then animals were tested in a social drinking paradigm (P37-P40), with this testing revealing high drinkers and low drinkers...
  40. Ni H, Zhao D, Tian T. Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures. Epilepsy Res. 2016;120:13-8 pubmed publisher
    ..Morris water maze test was performed during P37-P43...
  41. Sarkar S, Han J, Sinsimer K, Liao B, Foster R, Brewer G, et al. RNA-binding protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes. Mol Cell Biol. 2011;31:602-15 pubmed publisher
    ..LPS-mediated induction of IL10 gene expression requires the p40 isoform of the RNA-binding protein AUF1. As LPS exerts modest effects upon IL10 mRNA stability, we hypothesized that AUF1 controls the expression of ..
  42. Lo Y, Teo A, Tan Y, Fook Chong S, Guo C, Yue W, et al. Motor and somatosensory abnormalities are significant etiological factors for adolescent idiopathic scoliosis. J Neurol Sci. 2015;359:117-23 pubmed publisher
    ..For somatosensory evoked potentials (SSEP), peak to peak P37 amplitudes from right and left lower limb SSEP and inter-side P37 amplitude ratios were obtained...
  43. Zheng H, Hu P, Quinn D, Wang Y. Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. Mol Cell Proteomics. 2005;4:721-30 pubmed
    ..A specific site on alpha-tubulin (Tyr-271) was observed to be phosphorylated upon treatment as well. Furthermore, our results suggest that LOC257106, a CDC42 GAP-like protein, is potentially involved in this pathway. ..
  44. Ishii T, Hayakawa H, Igawa T, Sekiguchi T, Sekiguchi M. Specific binding of PCBP1 to heavily oxidized RNA to induce cell death. Proc Natl Acad Sci U S A. 2018;115:6715-6720 pubmed publisher
    ..We previously demonstrated that the human AUF1 protein binds to 8-oxoG in RNA to induce the selective degradation of oxidized messenger RNA...
  45. Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, et al. Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Mol Cell. 2018;72:766-777.e6 pubmed publisher
    ..Unlike p97-mediated degradative processes that require the Ufd1-Npl4 ubiquitin adapters, p97 is targeted to PP1 by p37 and related adapter proteins...
  46. Park H, Yoon J, Choi M. Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with heterogeneous nuclear ribonucleoprotein L. J Biosci. 2007;32:1263-72 pubmed
    ..Some of the cDNA clones were found to harbour a partial human hnRNP D/AUF1 cDNA (GeneBank accession number NM_031369)...
  47. Pautz A, Linker K, Altenhöfer S, Heil S, Schmidt N, Art J, et al. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. J Biol Chem. 2009;284:2755-66 pubmed publisher
    The ARE/poly-(U) binding factor 1 (AUF1), a protein family consisting of four isoforms, is believed to mediate mRNA degradation by binding to AU-rich elements (ARE)...
  48. Dolatshad H, Pellagatti A, Fernandez Mercado M, Yip B, Malcovati L, Attwood M, et al. Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells. Leukemia. 2015;29:1092-103 pubmed publisher
  49. Krishnan N, Titus M, Thapar R. The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins. PLoS ONE. 2014;9:e85427 pubmed publisher
    ..Pth, and TGF? mRNAs by interacting with the histone mRNA specific protein SLBP, and the ARE-binding proteins AUF1 and KSRP, respectively...
  50. Li C, Wu X, Zhang H, Yang G, Hao M, Sheng S, et al. A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway. Tumour Biol. 2015;36:6285-93 pubmed publisher
  51. Banihashemi L, Wilson G, Das N, Brewer G. Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay. Mol Cell Biol. 2006;26:8743-54 pubmed
    b>AUF1 is an RNA-binding protein that targets mRNAs containing A+U-rich elements (AREs) for rapid cytoplasmic turnover...
  52. Duan H, Qu L, Shou C. Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration. Cancer Cell Int. 2014;14:135 pubmed publisher
    ..hyorhinis infection was also abolished by PI3K inhibitor wortmannin. Furthermore, we found that p37, a membrane protein of M. hyorhinis, could also promote M...
  53. Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
    ..This study therefore substantially increases our understanding of the mechanisms by which IL-6 is regulated. ..
  54. Barker A, Epis M, Porter C, Hopkins B, Wilce M, Wilce J, et al. Sequence requirements for RNA binding by HuR and AUF1. J Biochem. 2012;151:423-37 pubmed publisher
    ..Binding by HuR generally leads to mRNA stabilization and increased protein production, whereas binding by AUF1 isoforms generally lead to rapid degradation of the mRNA and reduced protein production...
  55. Kishor A, Tandukar B, Ly Y, Toth E, Suarez Y, Brewer G, et al. Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements. Mol Cell Biol. 2013;33:71-84 pubmed publisher
  56. Thapar R. Roles of Prolyl Isomerases in RNA-Mediated Gene Expression. Biomolecules. 2015;5:974-99 pubmed publisher
    ..Pin1 also binds several RNA binding proteins such as AUF1, KSRP, HuR, and SLBP that regulate mRNA decay by remodeling mRNP complexes...
  57. Chen J, Liu L, Wei G, Wu W, Luo H, Yuan J, et al. The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1. Sci Rep. 2016;6:32189 pubmed publisher
    ..RNA-pull down assay, we found that Lnc_ASNR interacted with the protein ARE/poly (U)-binding/degradation factor 1(AUF1), which is reported to promote rapid degradation of the Bcl-2 mRNA, an inhibitor of apoptosis...
  58. Siomi M, Fromont M, Rain J, Wan L, Wang F, Legrain P, et al. Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol. 1998;18:4141-8 pubmed
    ..Together, these findings demonstrate that both the M9 signal and the nuclear import machinery utilized by the transportin pathway are conserved in evolution. ..
  59. Wu J, Wu L, Fang C, Nie R, Wang J, Wang X, et al. Mycoplasmal lipoprotein p37 binds human protein HER2. Microbiol Res. 2016;192:253-259 pubmed publisher
    Mycoplasmas are a group of microbes that can cause human diseases. The mycoplasmal lipoprotein p37 promotes cancer metastasis, at least in part, by interacting with EGFR...
  60. Yan J, Du F, Li S, Yuan Y, Jiang J, Li S, et al. AUF1 modulates TGF-? signal in renal tubular epithelial cells via post-transcriptional regulation of Nedd4L expression. Biochim Biophys Acta Mol Cell Res. 2018;1865:48-56 pubmed publisher
    ..AU-rich element RNA-binding protein (AUF1) interacts with and destabilizes mRNAs containing AU-rich elements (AREs) in their 3'UTR...
  61. Al Khalaf H, Aboussekhra A. p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1. Mol Carcinog. 2017;56:985-999 pubmed publisher
    ..senescence is not associated with secretory phenotype, and is mediated through the RNA binding protein AUF1. We have further demonstrated that p16INK4A and its downstream miRNA targets inhibit EMT through ..
  62. Huang J, Zhang A, Ho T, Zhang Z, Zhou N, Ding X, et al. Linc-RoR promotes c-Myc expression through hnRNP I and AUF1. Nucleic Acids Res. 2016;44:3059-69 pubmed publisher
    ..interacts with heterogeneous nuclear ribonucleoprotein (hnRNP) I and AU-rich element RNA-binding protein 1 (AUF1), respectively, with an opposite consequence to their interaction with c-Myc mRNA...
  63. Hajarnis S, Schroeder J, Curthoys N. 3'-Untranslated region of phosphoenolpyruvate carboxykinase mRNA contains multiple instability elements that bind AUF1. J Biol Chem. 2005;280:28272-80 pubmed
    ..4 h). RNA gel shift analyses established that AUF1 (hnRNP D) binds to the PCK-7, PCK-6, and PCK-2 segments with high affinity and specificity...
  64. Zucconi B, Wilson G. Assembly of functional ribonucleoprotein complexes by AU-rich element RNA-binding protein 1 (AUF1) requires base-dependent and -independent RNA contacts. J Biol Chem. 2013;288:28034-48 pubmed publisher
    AU-rich element RNA-binding protein 1 (AUF1) regulates the stability and/or translational efficiency of diverse mRNA targets, including many encoding products controlling the cell cycle, apoptosis, and inflammation by associating with AU-..
  65. Paschoud S, Dogar A, Kuntz C, Grisoni Neupert B, Richman L, Kühn L. Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1. Mol Cell Biol. 2006;26:8228-41 pubmed
    ..Overexpression of myc-tagged AUF1 p37 and p42 isoforms as well as suppression of endogenous AUF1 by RNA interference stabilized interleukin-6 mRNA...
  66. Geng Y, Zhang L, Xu M, Sheng W, Dong A, Cao J, et al. [The expression and significance of hnRNPD in esophageal squamous cell carcinoma cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:1659-63 pubmed
    ..Compared with the control group, siRNA targeting hnRNPD significantly promoted cell apoptosis. Down-regulation of hnRNPD inhibits the proliferation of ESCC cells by promoting cell apoptosis. ..
  67. Herrera J, Beisang D, Peterson M, Forster C, Gilbertsen A, Benyumov A, et al. Dicer1 Deficiency in the IPF Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis. Am J Respir Crit Care Med. 2018;: pubmed publisher
    ..Mechanistically, IPF ECM increased association of the Dicer1 transcript with RNA binding protein AUF1, and Dicer1 knockdown conferred primary human lung fibroblasts with cell-autonomous fibrogenicity in zebrafish and ..
  68. Arao Y, Kuriyama R, Kayama F, Kato S. A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D. Arch Biochem Biophys. 2000;380:228-36 pubmed
    One class of heterogeneous nuclear ribonucleoproteins (hnRNPs), AUF1/hnRNP D, consists of four isoform proteins (p45, p42, p40, and p37) which are generated by alternative splicing...
  69. Gao W, Li M, Zhang J. Tandem immunoprecipitation approach to identify HIV-1 Gag associated host factors. J Virol Methods. 2014;203:116-9 pubmed publisher
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    ..The first identified case of a de novo microtriplication at 4q21.21-q21.22 emphasizes the clinical significance of CNVs at 4q21 for patients with developmental delay and absence of speech. © 2016 Wiley Periodicals, Inc. ..
  71. Zarrei M, Merico D, Kellam B, Engchuan W, Scriver T, Jokhan R, et al. A de novo deletion in a boy with cerebral palsy suggests a refined critical region for the 4q21.22 microdeletion syndrome. Am J Med Genet A. 2017;173:1287-1293 pubmed publisher
    ..22 microdeletion region. We suggest that the deletion or misregulation of these genes is likely to contribute to the neurodevelopmental and neuromuscular abnormalities in 4q21.22 syndrome. ..
  72. Friedrich S, Schmidt T, Geissler R, Lilie H, Chabierski S, Ulbert S, et al. AUF1 p45 promotes West Nile virus replication by an RNA chaperone activity that supports cyclization of the viral genome. J Virol. 2014;88:11586-99 pubmed publisher
    ..Using in vitro and cell-based approaches, we defined the p45 isoform of AU-rich element RNA-binding protein 1 (AUF1) as a host factor that enables efficient WNV replication...
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    ..mRNA binding proteins have been discovered to date, which either stabilize (HuR/HuA, HuB, HuC, HuD) or destabilize (AUF1, tristetraprolin, KSRP) the target transcripts...
  74. Chenette D, Cadwallader A, Antwine T, Larkin L, Wang J, Olwin B, et al. Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity. Cell Rep. 2016;16:1379-1390 pubmed publisher
    ..We show that mRNA-decay protein AUF1 regulates satellite cell function through targeted degradation of specific mRNAs containing 3' AU-rich elements (..
  75. Wu S, Lin L, Zhao W, Li X, Wang Y, Si X, et al. AUF1 is recruited to the stress granules induced by coxsackievirus B3. Virus Res. 2014;192:52-61 pubmed publisher
    ..We further discovered that adenosine-uridine (AU)-rich element RNA binding factor 1 (AUF1), which can bind to mRNAs and regulate their translation, was recruited to the SGs in response to high dose of CVB3 ..
  76. van Zalen S, Lombardi A, Jeschke G, Hexner E, Russell J. AUF-1 and YB-1 independently regulate β-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein. Mech Dev. 2015;136:40-52 pubmed publisher
    ..These data specify a post-transcriptional mechanism through which AUF1 and YB1 contribute to the normal development of erythropoietic cells, as well as to non-hematopoietic tissues in ..
  77. Lin J, Brewer G, Li M. HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication. PLoS ONE. 2015;10:e0140291 pubmed publisher
    ..We reported recently that mRNA decay factor AUF1 is a negative-acting ITAF that binds IRES stem-loop II...
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    ..RBP AU-binding factor 1 (AUF1) has four isoforms resulting from alternative splicing and is critical for miRNA-mediated gene silencing with a ..
  79. Enokizono Y, Konishi Y, Nagata K, Ouhashi K, Uesugi S, Ishikawa F, et al. Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D. J Biol Chem. 2005;280:18862-70 pubmed
    Heterogeneous nuclear ribonucleoprotein D, also known as AUF1, has two DNA/RNA-binding domains, each of which can specifically bind to single-stranded d(TTAGGG)n, the human telomeric repeat...
  80. Huddleson J, Ahmad N, Lingrel J. Up-regulation of the KLF2 transcription factor by fluid shear stress requires nucleolin. J Biol Chem. 2006;281:15121-8 pubmed
    ..These data support a general role for nucleolin in gene regulation and identify it as a novel factor involved in regulation of KLF2 expression. ..
  81. Kemmerer K, Fischer S, Weigand J. Auto- and cross-regulation of the hnRNPs D and DL. RNA. 2018;24:324-331 pubmed publisher
    HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies...
  82. Pioli P, Hamilton B, Connolly J, Brewer G, Rigby W. Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1. J Biol Chem. 2002;277:35738-45 pubmed
    ..Polysomal localization of LDH was dependent on RNA binding. Moreover, polysomal LDH exists in a complex with AUF1 and hsp-70, which has been implicated previously in the regulation of mRNA turnover...
  83. Bell O, Gaberman E, Kilav R, Levi R, Cox K, Molkentin J, et al. The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. Mol Endocrinol. 2005;19:516-26 pubmed
    ..One of these proteins is adenosine-uridine-rich binding factor (AUF1), whose levels are not regulated in PT extracts from rats fed the different diets...
  84. Ikeda T, Yoshitomi Y, Saito H, Shimasaki T, Yamaya H, Kobata T, et al. Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation. Mol Cell Biochem. 2016;413:155-64 pubmed publisher
    ..These findings indicate that hnRNP D and arginine methylation play important roles in the regulation of Flt-1 mRNA alternative polyadenylation. ..
  85. Wu X, Yang Y, Huang Y, Chen Y, Wang T, Wu S, et al. RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma. Oncotarget. 2018;9:14815-14827 pubmed publisher
    ..Here we report that the AU-rich element-binding factor AUF1 suppresses the expression of Dicer1, the type III RNase that is required for microRNA maturation, leading to the ..
  86. Lu M, Pan C, Zhang L, Ding C, Chen F, Wang Q, et al. ING4 inhibits the translation of proto-oncogene MYC by interacting with AUF1. FEBS Lett. 2013;587:1597-604 pubmed publisher
    The ING4 tumor suppressor plays a significant role in various cancer-related cellular processes. AUF1 affects the stability and/or translation of multiple mRNAs via binding to an AU-rich element in the 3'-untranslated regions...
  87. Lee K, Kim S, Kim H, Kim W, Lee H, Jung Y, et al. AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation. Nucleic Acids Res. 2014;42:3590-606 pubmed publisher
    ..We found that AU-rich element RNA binding protein 1 (AUF1) directly binds to the Cry1 3'UTR and regulates translation of Cry1 mRNA...
  88. Torres L, Garcia R, Blois A, Dati L, Durão A, Alves A, et al. Exposure of Neonatal Mice to Tobacco Smoke Disturbs Synaptic Proteins and Spatial Learning and Memory from Late Infancy to Early Adulthood. PLoS ONE. 2015;10:e0136399 pubmed publisher
    ..Spatial reference and working memory were evaluated in the Morris water maze during infancy (P20-P29), adolescence (P37-P42) and adulthood (P67-P72)...
  89. Sun S, Zhang X, Lyu L, Li X, Yao S, Zhang J. Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1. J Biol Chem. 2016;291:25823-25836 pubmed
    ..The RNA-binding proteins HuR and AUF1 directly bound to the ATX mRNA 3'UTR and had antagonistic functions in ATX expression...
  90. Shimizu Y, Mullins N, Blanchard Z, ElShamy W. BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells. Oncotarget. 2012;3:299-313 pubmed
    ..in normal human mammary epithelial (HME) cells reduces expression of two RNA-destabilizing proteins, namely AUF1 and pCBP2, both proteins bind and destabilize BRCA1-IRIS mRNA...
  91. Gomersall A, Phan H, Iacuone S, Li S, Parish R. The Mycoplasma hyorhinis p37 Protein Rapidly Induces Genes in Fibroblasts Associated with Inflammation and Cancer. PLoS ONE. 2015;10:e0140753 pubmed publisher
    The p37 protein at the surface of Mycoplasma hyorhinis cells forms part of a high-affinity transport system and has been found associated with animal and human cancers...
  92. Fotinos A, Fritz D, Lisica S, Liu Y, Rogers M. Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells. J Cell Biochem. 2016;117:439-47 pubmed publisher
    ..Mutational and RNA-interference evidence also supports an AUF1 (AU-factor-1, HNRNPD, HGNC:5036) contribution to the observed repressive activity of the 3'UTR in mesenchymal cells...