Gene Symbol: ATP9A
Description: ATPase phospholipid transporting 9A (putative)
Alias: ATPIIA, ATPase type IV, phospholipid-transporting (P-type),(putative), ATPase, class II, type 9A, phospholipid-transporting ATPase IIA
Kim K, Seibert J, Edea Z, Graves K, Kim E, Keating A, et al
. Characterization of the acute heat stress response in gilts: III. Genome-wide association studies of thermotolerance traits in pigs. J Anim Sci. 2018;96:2074-2085 pubmed publisher
..associated with ΔRR (PAIP1, NNT, and TEAD4), ΔTR (LIMS2, TTR, and TEAD4), and ΔTS (ERBB4, FKBP1B, NFATC2, and ATP9A) have reported roles in the cellular stress response...
McGough I, de Groot R, Jellett A, Betist M, Varandas K, Danson C, et al
. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. Nat Commun. 2018;9:3737 pubmed publisher
..membrane re-modelling complex composed of MON2, DOPEY2 and the putative aminophospholipid translocase, ATP9A. In vivo suppression of Ce-mon-2, Ce-pad-1 or Ce-tat-5 (respective MON2, DOPEY2 and ATP9A orthologues) phenocopy a ..
Richmond R, Simpkin A, Woodward G, Gaunt T, Lyttleton O, McArdle W, et al
. Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Hum Mol Genet. 2015;24:2201-17 pubmed publisher
..In cord blood, methylation at 15 CpG sites in seven gene regions (AHRR, MYO1G, GFI1, CYP1A1, CNTNAP2, KLF13 and ATP9A) was associated with maternal smoking, and a dose-dependent response was observed in relation to smoking duration ..
Teranishi Y, Inoue M, Yamamoto N, Kihara T, Wiehager B, Ishikawa T, et al
. Proton myo-inositol cotransporter is a novel Î³-secretase associated protein that regulates AÎ² production without affecting Notch cleavage. FEBS J. 2015;282:3438-51 pubmed publisher
..In summary, SLC2A13 was identified as a novel GSAP that regulates AÎ² production without affecting Notch cleavage. We suggest that SLC2A13 could be a target for AÎ² lowering therapy aimed at treating Alzheimer's disease. ..
Chaubey P, Hofstetter L, Roschitzki B, Stieger B. Proteomic Analysis of the Rat Canalicular Membrane Reveals Expression of a Complex System of P4-ATPases in Liver. PLoS ONE. 2016;11:e0158033 pubmed publisher
..In addition to ATP8B1, four more P4-ATPases were identified. ATP8A1 and ATP9A showed expression specific to the canalicular membrane, ATP11C at the bLPM and ATP11A in an intracellular ..
Tanaka Y, Ono N, Shima T, Tanaka G, Katoh Y, Nakayama K, et al
. The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane. Mol Biol Cell. 2016;27:3883-3893 pubmed
..We previously reported that ATP9A, one of 14 human P4-ATPases, is localized to endosomal compartments and the Golgi complex...
Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al
. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...
Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, et al
. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. J Biol Chem. 2011;286:38159-67 pubmed publisher
..In contrast, class 2 P4-ATPases (ATP9A and ATP9B) are able to exit the ER in the absence of exogenous CDC50 expression: ATP9B, but not ATP11B, was able ..
Ansari I, Longacre M, Paulusma C, Stoker S, Kendrick M, MacDonald M. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. J Biol Chem. 2015;290:23110-23 pubmed publisher
..predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG. ATP9A was concentrated in plasma membrane...