Gene Symbol: ATP8B2
Description: ATPase phospholipid transporting 8B2
Alias: ATPID, phospholipid-transporting ATPase ID, 36/8-9 fusion protein with epitope for anti-lectin antibody, ATPase, aminophospholipid transporter, class I, type 8B, member 2, ATPase, class I, type 8B, member 2, P4-ATPase flippase complex alpha subunit ATP8B2
Species: human
Products:     ATP8B2

Top Publications

  1. Naito T, Takatsu H, Miyano R, Takada N, Nakayama K, Shin H. Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics. J Biol Chem. 2015;290:15004-17 pubmed publisher
    ..activity toward aminophospholipids (phosphatidylserine (PS) and phosphatidylethanolamine (PE)) and ATP8B1 and that ATP8B2 have flippase activity toward phosphatidylcholine (PC) (Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S...
  2. Wang J, Molday L, Hii T, Coleman J, Wen T, Andersen J, et al. Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues. Sci Rep. 2018;8:10795 pubmed publisher
    ..ATP8B1 was detected only in liver, ATP8B3 and ATP10A only in testes, and ATP8B2 primarily in brain...
  3. Takatsu H, Tanaka G, Segawa K, Suzuki J, Nagata S, Nakayama K, et al. Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014;289:33543-56 pubmed publisher
    ..flippase activities of plasma membrane-localized P4-ATPases using human cell lines stably expressing ATP8B1, ATP8B2, ATP11A, and ATP11C...
  4. Lv Q, Lan Y, Shi Y, Wang H, Pan X, Li P, et al. AtPID: a genome-scale resource for genotype-phenotype associations in Arabidopsis. Nucleic Acids Res. 2017;45:D1060-D1063 pubmed publisher
    b>AtPID (Arabidopsis thaliana Protein Interactome Database, available at is an integrated database resource for protein interaction network and functional annotation...
  5. Zhu J, Dubois A, Ge Y, Olson J, Ren X. Application of human haploid cell genetic screening model in identifying the genes required for resistance to environmental toxicants: Chlorpyrifos as a case study. J Pharmacol Toxicol Methods. 2015;76:76-82 pubmed publisher
    ..9 human genes in which the cells carrying these genes conferred the resistance to CPF, including AGPAT6, AIG1, ATP8B2, BIK, DCAF12, FNBP4, LAT2, MZF1-AS1 and PPTC7...
  6. Paulusma C, Oude Elferink R. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Biochim Biophys Acta. 2005;1741:11-24 pubmed
  7. Ansari I, Longacre M, Paulusma C, Stoker S, Kendrick M, MacDonald M. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. J Biol Chem. 2015;290:23110-23 pubmed publisher
    ..that the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG. ATP9A was concentrated in plasma membrane...
  8. Abbott W, Mellor A, Edwards Y, Feizi T. Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein. Biochem J. 1989;259:283-90 pubmed
    ..In myelin basic protein the tetrapeptide is a part of the major domain previously shown to be responsible for the induction of experimental allergic encephalomyelitis. ..
  9. Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
    ..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...

More Information


  1. Harris M, Arias I. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Biochim Biophys Acta. 2003;1633:127-31 pubmed
    ..We identified two familial intrahepatic cholestasis type 1 (FIC1) homologues, ATP8B2 and ATP8B3, with 53% and 45% amino acid identity, respectively...
  2. van der Velden L, Wichers C, van Breevoort A, Coleman J, Molday R, Berger R, et al. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem. 2010;285:40088-96 pubmed publisher
    ..ATP8B1 and ATP8B2 co-immunoprecipitated with CDC50A and CDC50B, whereas ATP8B4, ATP8A1, and ATP8A2 associated only with CDC50A...