ATP8A2

Summary

Gene Symbol: ATP8A2
Description: ATPase phospholipid transporting 8A2
Alias: ATP, ATPIB, CAMRQ4, ML-1, phospholipid-transporting ATPase IB, ATPase, aminophospholipid transporter, class I, type 8A, member 2, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2, P4-ATPase flippase complex alpha subunit ATP8A2
Species: human
Products:     ATP8A2

Top Publications

  1. Coleman J, Kwok M, Molday R. Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes. J Biol Chem. 2009;284:32670-9 pubmed publisher
    ..In this study, we report on the localization and functional properties of Atp8a2, a member of the P(4)-ATPase subfamily that has not been studied previously...
  2. Cacciagli P, Haddad M, Mignon Ravix C, El Waly B, Moncla A, Missirian C, et al. Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype. Eur J Hum Genet. 2010;18:1360-3 pubmed publisher
    ..The translocation breakpoint disrupts the coding sequence of a single gene, called ATP8A2. The ATP8A2 gene is not ubiquitously expressed, but it is highly expressed in the brain...
  3. van der Velden L, Wichers C, van Breevoort A, Coleman J, Molday R, Berger R, et al. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem. 2010;285:40088-96 pubmed publisher
    ..ATP8B1 and ATP8B2 co-immunoprecipitated with CDC50A and CDC50B, whereas ATP8B4, ATP8A1, and ATP8A2 associated only with CDC50A...
  4. Coleman J, Molday R. Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2. J Biol Chem. 2011;286:17205-16 pubmed publisher
    ..Previously, we have shown that the P(4)-ATPase ATP8A2 purified from photoreceptor membranes and reconstituted into liposomes catalyzes the active transport of ..
  5. Onat O, Gulsuner S, Bilguvar K, Nazli Basak A, Topaloglu H, Tan M, et al. Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion. Eur J Hum Genet. 2013;21:281-5 pubmed publisher
    ..I376M, in ATP8A2. The mutation lies in a highly conserved C-terminal transmembrane region of E1 E2 ATPase domain...
  6. Henning R, Bourgeois M, Harbison R. Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. Cardiovasc Toxicol. 2018;18:493-506 pubmed publisher
    ..adenine dinucleotide (NAD+) which slows the rate of glycolysis, mitochondrial electron transport, and ultimately ATP formation in these cells...
  7. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
    ..b>Abbreviations: Abcg5: ATP-binding cassette subfamily G member 5; ALT: alanine aminotransferase; AMPK: adenosine monophosphate-activated ..
  8. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..basic phenotype dominance in the SK-MEL-3 cell line for i) synthesis of melanin, ii) phagosome acidification, iii) ATP hydrolysis-coupled proton pumps and iv) iron transport systems...
  9. Jellinger P, Handelsman Y, Rosenblit P, Bloomgarden Z, Fonseca V, Garber A, et al. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE. Endocr Pract. 2017;23:1-87 pubmed publisher
    ..in Metabolic Syndrome With Low HDL/High Triglycerides trial ASCVD = atherosclerotic cardiovascular disease ATP = Adult Treatment Panel apo = apolipoprotein BEL = best evidence level BIP = Bezafibrate Infarction Prevention ..

More Information

Publications158 found, 100 shown here

  1. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..mutation in the mitochondrial DNA leads to a loss of functionality of the OXPHOS system and thus to a depletion of ATP and overproduction of ROS, which can, in turn, induce further mtDNA mutations...
  2. Kurpińska A, Suraj J, Bonar E, Zakrzewska A, Stojak M, Sternak M, et al. Proteomic characterization of early lung response to breast cancer metastasis in mice. Exp Mol Pathol. 2019;107:129-140 pubmed publisher
    ..90-beta (Hsp90ab1)], but also modifications in metabolic pathways [glucose-6-phosphate 1-dehydrogenase X (G6pdx), ATP synthase subunit beta, mitochondrial (Atp5b), L-lactate dehydrogenase B chain (Ldhb)]...
  3. McCully K. Review: Chemical Pathology of Homocysteine VI. Aging, Cellular Senescence, and Mitochondrial Dysfunction. Ann Clin Lab Sci. 2018;48:677-687 pubmed
    ..The theory of oxidative phosphorylation attributes mitochondrial adenosine triphosphate (ATP) synthesis to the active site, thioretinaco ozonide oxygen NAD+ phosphate, which couples polymerization ..
  4. Yu H, Wang D, Zou L, Zhang Z, Xu H, Zhu F, et al. Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer's disease. Arch Toxicol. 2018;92:1363-1382 pubmed publisher
    ..impairment of these animals, increased accumulation of intracellular amyloid 1-42 (Aβ1-42), decreased ATP content, increased the positive staining of 8-hydroxyguanosine (8-OHdG), a marker of DNA oxidative damage, and ..
  5. Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich T, et al. Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. Hum Reprod. 2016;31:133-49 pubmed publisher
    ..localization of polyadenylated RNAs, proteins of maternal effect genes (transcription activator BRG1 also known as ATP-dependent helicase SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member ..
  6. Banerjee S, Aykin Burns N, Krager K, Shah S, Melnyk S, Hauer Jensen M, et al. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016;99:296-307 pubmed publisher
    ..bioenergetics revealed that irradiated KO MEFs showed significant reductions in basal, adenosine triphosphate (ATP)-linked, maximal respiration and reserved respiratory capacity and decrease in intracellular ATP levels compared to ..
  7. Xie W, Zhou P, Sun Y, Meng X, Dai Z, Sun G, et al. Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies. Cells. 2018;7: pubmed publisher
    ..ERK1/2, PI3K-Akt/mTOR, PKB/Akt and HIF-1α/VEGF pathways); and energy metabolism and the regulation of cellular ATP levels, the blood-brain barrier and other effects via N-methyl-D-aspartic acid (NMDA) receptors, ERS, and AMP/AMPK-..
  8. Khanra R, Dewanjee S, K Dua T, Sahu R, Gangopadhyay M, De Feo V, et al. Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. J Transl Med. 2015;13:6 pubmed publisher
    ..T2DM altered the redox status, decreased the intracellular NAD and ATP concentrations in renal and myocardial tissues of experimental rats...
  9. Arunachalam K, Damazo A, Pavan E, Oliveira D, Figueiredo F, Machado M, et al. Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models. J Ethnopharmacol. 2019;233:101-114 pubmed publisher
    ..p.), an inhibitor of nitric oxide synthase, glibenclamide, a ATP-sensitive potassium channels (K+ATP) blocker (5 mg/kg, p.o.) or yohimbine (2 mg/kg, i.p...
  10. McDonald N, Lubin J, Chowdhury N, Boyd E. Host-Derived Sialic Acids Are an Important Nutrient Source Required for Optimal Bacterial Fitness In Vivo. MBio. 2016;7:e02237-15 pubmed publisher
    ..cholerae can grow efficiently on intestinal mucus and its component sialic acids and that a tripartite ATP-independent periplasmic SiaPQM strain, transporter-deficient mutant NC1777, was attenuated for colonization using a ..
  11. Nelson N, Harvey W. Vacuolar and plasma membrane proton-adenosinetriphosphatases. Physiol Rev. 1999;79:361-85 pubmed
    ..In contrast to F-ATPases, whose primary function in eukaryotic cells is to form ATP at the expense of the proton-motive force (pmf), V-ATPases function exclusively as ATP-dependent proton pumps...
  12. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..sterol regulatory element-binding protein-2 (SREBP-2), acetyl-CoA carboxylase (ACC), HMG-CoA reductase (HMGCR), ATP-binding cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase (CYP7A1), and sterol 12-alpha-..
  13. Singh P, Gupta S, Sharma B. Melatonin receptor and KATP channel modulation in experimental vascular dementia. Physiol Behav. 2015;142:66-78 pubmed publisher
    ..been structured to investigate the role of agomelatine, a melatonergic MT1/MT2 agonist and nicorandil, a selective ATP sensitive potassium (KATP) channel opener in renal artery ligation (two-kidney-one-clip: 2K1C) hypertension induced ..
  14. Loshaj Shala A, Colzani M, Brezovska K, Poceva Panovska A, Suturkova L, Beretta G. Immunoproteomic identification of antigenic candidate Campylobacter jejuni and human peripheral nerve proteins involved in Guillain-Barré syndrome. J Neuroimmunol. 2018;317:77-83 pubmed publisher
    ..filaments (vimentin and desmin), and other proteins and enzymes such as troponin/tropomyosin complex and ATP synthase subunit beta and the keratan sulfate proteoglycan lumican...
  15. Seara F, Barbosa R, de Oliveira D, Gran da Silva D, Carvalho A, Freitas Ferreira A, et al. Administration of anabolic steroid during adolescence induces long-term cardiac hypertrophy and increases susceptibility to ischemia/reperfusion injury in adult Wistar rats. J Steroid Biochem Mol Biol. 2017;171:34-42 pubmed publisher
    ..II (AT1) receptor mediates cardiac hypertrophy induced by AAS and also induces down-regulation of myocardial ATP-sensitive potassium channel (KATP), resulting in loss of exercise-induced cardioprotection...
  16. Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, et al. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice. J Ethnopharmacol. 2017;198:479-488 pubmed publisher
    ..were collected to study the impact of HLF on cholesterol efflux, formation of foam cell and the expression of ATP binding cassette transporter A1 (ABCA1). Besides, in vivo reverse cholesterol transport (RCT) was conducted...
  17. Sas K, Szabó E, Vecsei L. Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection. Molecules. 2018;23: pubmed publisher
    ..In the case of extensive DNA damage, PARP-1 becomes overactivated and rapidly depletes the intracellular NAD⁺ and ATP pools. This results in a profound energy loss of the cell and leads to cell dysfunction, or even cell death...
  18. Al Omairi N, Al Brakati A, Kassab R, Lokman M, Elmahallawy E, Amin H, et al. Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. Metab Brain Dis. 2019;: pubmed publisher
    ..The level of ATP increased...
  19. Bhattacharjee N, Khanra R, Dua T, Das S, De B, Zia Ul Haq M, et al. Sansevieria roxburghiana Schult. & Schult. F. (Family: Asparagaceae) Attenuates Type 2 Diabetes and Its Associated Cardiomyopathy. PLoS ONE. 2016;11:e0167131 pubmed publisher
    ..T2DM altered the redox status (p < 0.05-0.01), decreased (p < 0.01) the intracellular NAD and ATP concentrations in the myocardial tissues of experimental rats...
  20. Wang P, Hu Y, Yao D, Li Y. Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy. Cell Physiol Biochem. 2018;49:2163-2173 pubmed publisher
    ..UCF-101 also reversed the decreased mitochondrial complex I, II, and III respiration and the reduced ATP caused by CLP...
  21. Yagami T, Yamamoto Y, Koma H. Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases. Mol Neurobiol. 2019;56:3090-3112 pubmed publisher
    ..Necrosis is featured by the disruption of plasma membranes and lysosomes, the loss of ATP and ribosomes, the lysis of cell and nucleus, and the caspase-independent DNA fragmentation...
  22. Völgyi K, Gulyássy P, Háden K, Kis V, Badics K, Kékesi K, et al. Synaptic mitochondria: a brain mitochondria cluster with a specific proteome. J Proteomics. 2015;120:142-57 pubmed publisher
    ..as well as some tricarboxylic acid cycle proteins, including isocitrate dehydrogenase subunit alpha (Idh3a) and ATP-forming β subunit of succinyl-CoA ligase (SuclA2), were verified by Western blot, the latter two also by ..
  23. Ilyas S, Rehman A, Coelho A, Sheehan D. Proteomic analysis of an environmental isolate of Rhodotorula mucilaginosa after arsenic and cadmium challenge: Identification of a protein expression signature for heavy metal exposure. J Proteomics. 2016;141:47-56 pubmed publisher
    ..20S proteasome subunit, eukaryotic translation elongation factor 2, valine-tRNA ligase and a metabolic enzyme F0F1 ATP synthase alpha subunit were all expressed as well as a unique hypothetical protein...
  24. Del Castillo Velasco Martínez I, Hernández Camacho C, Méndez Rodríguez L, Zenteno Savín T. Purine metabolism in response to hypoxic conditions associated with breath-hold diving and exercise in erythrocytes and plasma from bottlenose dolphins (Tursiops truncatus). Comp Biochem Physiol A Mol Integr Physiol. 2016;191:196-201 pubmed publisher
    In mammalian tissues under hypoxic conditions, ATP degradation results in accumulation of purine metabolites. During exercise, muscle energetic demand increases and oxygen consumption can exceed its supply...
  25. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..The activities of superoxide dismutase (SOD), glutathoinine peroxidase (GPx) and cytochrome c oxidase (COX) and the ATP level were significantly reduced after CdCl2 exposure...
  26. Sato Y, Watanabe R, Uchiyama N, Ozawa N, Takahashi Y, Shirai R, et al. Inhibitory effects of vasostatin-1 against atherogenesis. Clin Sci (Lond). 2018;132:2493-2507 pubmed publisher
    ..foam cell formation associated with acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) and CD36 down-regulation and ATP-binding cassette transporter A1 (ABCA1) up-regulation in macrophages...
  27. Roskoski R. Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs. Pharmacol Res. 2019;139:471-488 pubmed publisher
    ..These inhibitors bind in the cleft between the N-terminal and C-terminal lobes of the CDKs and they inhibit ATP binding...
  28. Han J, Gao P, Zhao S, Bie X, Lu Z, Zhang C, et al. iTRAQ-based proteomic analysis of LI-F type peptides produced by Paenibacillus polymyxa JSa-9 mode of action against Bacillus cereus. J Proteomics. 2017;150:130-140 pubmed publisher
    ..multiple experiments were conducted to validate the results of the proteomic analysis, including determinations of ATP, NAD(+)H, NADP(+)H, reactive oxygen species (ROS), the activities of catalase (CAT) and ..
  29. Tedesco D, Thapa M, Chin C, Ge Y, Gong M, Li J, et al. Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic ?? T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology. 2018;154:2178-2193 pubmed publisher
    ..This pathway appears to contribute to development of cholestatic liver disease in patients. ..
  30. Ghosh G, Reddy J, Sambhare S, Sen R. A Bacteriophage Capsid Protein Is an Inhibitor of a Conserved Transcription Terminator of Various Bacterial Pathogens. J Bacteriol. 2018;200: pubmed publisher
    ..and Pseudomonas syringae The purified recombinant Rho proteins of these organisms showed variable rates of ATP hydrolysis on poly(rC) as the substrate and were capable of releasing RNA from the E...
  31. Reddy P, Yin X, Manczak M, Kumar S, Pradeepkiran J, Vijayan M, et al. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease. Hum Mol Genet. 2018;27:2502-2516 pubmed publisher
    ..These observations strongly suggest that accumulation of mAPP and Aβ causes mitochondrial, synaptic and autophagy/mitophagy abnormalities in hippocampal neurons, leading to neuronal dysfunction. ..
  32. Gurunathan S, Kim J. Biocompatible Gold Nanoparticles Ameliorate Retinoic Acid-Induced Cell Death and Induce Differentiation in F9 Teratocarcinoma Stem Cells. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..levels of malondialdehyde and nitric oxide, loss of mitochondrial membrane potential, and a reduced level of ATP. Finally, RA increased the level of pro-apoptotic gene expression and decreased the expression of anti-apoptotic ..
  33. Jellinger P, Handelsman Y, Rosenblit P, Bloomgarden Z, Fonseca V, Garber A, et al. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE - EXECUTIVE SUMMARYComplete Appendix to Guidelines available at http://journals. Endocr Pract. 2017;23:479-497 pubmed publisher
    ..ACS = acute coronary syndrome AHA = American Heart Association ASCVD = atherosclerotic cardiovascular disease ATP = Adult Treatment Panel apo = apolipoprotein BEL = best evidence level CKD = chronic kidney disease CPG = clinical ..
  34. Ip B, Liu C, Lichtenstein A, von Lintig J, Wang X. Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. J Nutr. 2015;145:268-76 pubmed publisher
    ..protein kinase phosphorylation, 67%], and elevated cholesterol efflux genes (cytochrome P450 family 7A1, 65%; ATP-binding cassette transporter G5/8, 11%)...
  35. Roth Z. PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Cellular and molecular mechanisms of heat stress related to bovine ovarian function. J Anim Sci. 2015;93:2034-44 pubmed publisher
    ..with impaired expression of both nuclear (succinate dehydrogenase subunit [SDHD], adenosine triphosphate [ATP] synthase subunit beta [ATP5B]), mitochondrially NADH dehydrogenase subunit 2 (ND2), and mitochondiral (cytochrome ..
  36. Lamontagne Boulet M, Isabelle C, Guay I, Brouillette E, Langlois J, Jacques P, et al. Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..aureus strains to identify mutations in genes involved in resistance, we identified the bacterial ATP synthase as the cellular target...
  37. Jackson S, Manolaridis I, Kowal J, Zechner M, Taylor N, Bause M, et al. Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat Struct Mol Biol. 2018;25:333-340 pubmed publisher
    ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance...
  38. Leth M, Ejby M, Workman C, Ewald D, Pedersen S, Sternberg C, et al. Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut. Nat Microbiol. 2018;3:570-580 pubmed publisher
    ..This xylanase operates in concert with an ATP-binding cassette transporter to mediate breakdown and selective internalization of xylan fragments...
  39. Yuan Y, Martsinkevich O, Hunt J. Structural characterization of an MJ1267 ATP-binding cassette crystal with a complex pattern of twinning caused by promiscuous fiber packing. Acta Crystallogr D Biol Crystallogr. 2003;59:225-38 pubmed
    b>ATP-binding cassettes represent the motor domains in ABC transporters, a superfamily of integral membrane-protein pumps that couple the hydrolysis of ATP to transmembrane solute translocation...
  40. Schnepf R, Zolk O. Effect of the ATP-binding cassette transporter ABCG2 on pharmacokinetics: experimental findings and clinical implications. Expert Opin Drug Metab Toxicol. 2013;9:287-306 pubmed publisher
    The ATP-binding cassette transporter ABCG2 can actively extrude a broad range of endogenous and exogenous substrates across biological membranes...
  41. Starr L, Koski K, Scott M. Expression of growth-related genes in the mouse placenta is influenced by interactions between intestinal nematode (Heligmosomoides bakeri) infection and dietary protein deficiency. Int J Parasitol. 2016;46:97-104 pubmed publisher
    ..including genes related to oxidative phosphorylation, and up-regulated 214 transcripts, including genes involved in ATP binding and hemopoiesis...
  42. Li H, Karl T, Garner B. Understanding the function of ABCA7 in Alzheimer's disease. Biochem Soc Trans. 2015;43:920-3 pubmed publisher
    b>ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain. Recent genome-wide association studies (GWAS) identify ABCA7 single nt polymorphisms (SNPs) that increase Alzheimer's disease (AD) risk...
  43. Landa Juárez A, Ortiz M, Castaneda Hernandez G, Chávez Piña A. Participation of potassium channels in the antinociceptive effect of docosahexaenoic acid in the rat formalin test. Eur J Pharmacol. 2016;793:95-100 pubmed publisher
    ..05). Local peripheral administration of tolbutamide and glibenclamide (Kir6.1-2; ATP-sensitive K+ channel blockers); iberiotoxin and charybdotoxin (KCa1...
  44. Dréan A, Rosenberg S, Lejeune F, Goli L, Nadaradjane A, Guehennec J, et al. ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma. J Neurooncol. 2018;138:479-486 pubmed publisher
    b>ATP-binding cassette transporters (ABC transporters) regulate traffic of multiple compounds, including chemotherapeutic agents, through biological membranes...
  45. Yatsenko A, Wiszniewski W, Zaremba C, Jamrich M, Lupski J. Evolution of ABCA4 proteins in vertebrates. J Mol Evol. 2005;60:72-80 pubmed
    The ABCA4 (ABCR) gene encodes a retinal-specific ATP-binding cassette transporter. Mutations in ABCA4 are responsible for several recessive macular dystrophies and susceptibility to age related macular degeneration (AMD)...
  46. An R, Hagiya Y, Tamura A, Li S, Saito H, Tokushima D, et al. Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. Pharm Res. 2009;26:449-58 pubmed publisher
    The physiological importance of the human ATP-binding cassette (ABC) transporter ABCG2 has been recognized with regard to porphyrin-mediated photosensitivity...
  47. Doczi J, Torocsik B, Echaniz Laguna A, Mousson de Camaret B, Starkov A, Starkova N, et al. Alterations in voltage-sensing of the mitochondrial permeability transition pore in ANT1-deficient cells. Sci Rep. 2016;6:26700 pubmed publisher
    ..Matrix Ca(2+) levels measured by X-rhod-1 or mitochondrially-targeted ratiometric biosensor 4mtD3cpv, or ADP-ATP exchange rates did not differ among cell types...
  48. Estévez Herrera J, Domínguez N, Pardo M, González Santana A, Westhead E, Borges R, et al. ATP: The crucial component of secretory vesicles. Proc Natl Acad Sci U S A. 2016;113:E4098-106 pubmed publisher
    The colligative properties of ATP and catecholamines demonstrated in vitro are thought to be responsible for the extraordinary accumulation of solutes inside chromaffin cell secretory vesicles, although this has yet to be demonstrated in ..
  49. Roy Chowdhury S, Khdour O, Bandyopadhyay I, Hecht S. Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction. Bioorg Med Chem. 2017;25:5537-5547 pubmed publisher
    ..The analogues also preserved mitochondrial membrane potential and augmented ATP production...
  50. Uygun Z, Sahin C, Yilmaz M, Akçay Y, Akdemir A, Sağın F. Fullerene-PAMAM(G5) composite modified impedimetric biosensor to detect Fetuin-A in real blood samples. Anal Biochem. 2018;542:11-15 pubmed publisher
    ..Firstly, a self-assembly monolayer (SAM) was formed on gold surface by 4-aminothiophenol (4-ATP), Fullerene and PAMAM-NH2 (G5), layers were formed, consecutively...
  51. Schmitz G, Kaminski W. ABC transporters and cholesterol metabolism. Front Biosci. 2001;6:D505-14 pubmed
    b>ATP-binding cassette (ABC) proteins form a group of highly conserved cellular transmembrane transporters. Studies over the past year have implicated ABC transporters in cellular lipid trafficking processes...
  52. Sheng L, Liu C, Tong Q, Ma M. Central metabolic pathways of Aureobasidium pullulans CGMCC1234 for pullulan production. Carbohydr Polym. 2015;134:333-6 pubmed publisher
    ..Compared to the control group, the ratio of ATP/ADP of 0.60 mM iodoacetic acid group was lower at different stages of pullulan fermentation...
  53. Ocampo J, Chereji R, Eriksson P, Clark D. The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo. Nucleic Acids Res. 2016;44:4625-35 pubmed publisher
    ..Thus, competition between the two remodelers to set the spacing on each gene may result in a highly dynamic chromatin structure. ..
  54. Scott K, Benkhalti M, Calvert N, Paquette M, Zhen L, Harper M, et al. KATP channel deficiency in mouse FDB causes an impairment of energy metabolism during fatigue. Am J Physiol Cell Physiol. 2016;311:C559-C571 pubmed publisher
    The skeletal muscle ATP-sensitive K+ (KATP) channel is crucial in preventing fiber damage and contractile dysfunction, possibly by preventing damaging ATP depletion...
  55. Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S. Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Res. 2017;: pubmed publisher
    Mycobacterial Lhr is a DNA damage-inducible superfamily 2 helicase that uses adenosine triphosphate (ATP) hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes en route...
  56. Maugeri A, van Driel M, van de Pol D, Klevering B, van Haren F, Tijmes N, et al. The 2588G-->C mutation in the ABCR gene is a mild frequent founder mutation in the Western European population and allows the classification of ABCR mutations in patients with Stargardt disease. Am J Hum Genet. 1999;64:1024-35 pubmed
    In 40 western European patients with Stargardt disease (STGD), we found 19 novel mutations in the retina-specific ATP-binding cassette transporter (ABCR) gene, illustrating STGD's high allelic heterogeneity...
  57. Civelek M, Grant G, Irolla C, Shi C, Riley R, Chiesa O, et al. Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo. Am J Physiol Heart Circ Physiol. 2010;298:H163-70 pubmed publisher
    ..Cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) was upregulated at all sites in response to short-term high-fat diet...
  58. Xiong J, Todorova D, Su N, Kim J, Lee P, Shen Z, et al. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. J Cell Biol. 2015;208:513-20 pubmed publisher
    ..Sall4 also interacts with Baf60a, a member of the SWI/SNF (switch/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage...
  59. Dambacher C, Worden E, Herzik M, Martin A, Lander G. Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. elife. 2016;5:e13027 pubmed publisher
    The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins...
  60. Shang D, Wu J, Guo L, Xu Y, Liu L, Lu J. Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2. Int J Oncol. 2017;50:1848-1856 pubmed publisher
    ..PKM2 downregulation resulted in, metformin inhibited glucose uptake, lactate production and ATP production in HOS CSCs...
  61. Luo J, Tao Q, Wu K, Li J, Qian J, Liang Y, et al. Structural and functional variability in root-associated bacterial microbiomes of Cd/Zn hyperaccumulator Sedum alfredii. Appl Microbiol Biotechnol. 2017;101:7961-7976 pubmed publisher
    ..The functional categories involved in membrane transporters (specifically ATP-binding cassette transporters) and energy metabolism were overrepresented in endosphere of HP in comparison with ..
  62. Ruiz M, Bégou M, Launay N, Ranea Robles P, Bianchi P, López Erauskin J, et al. OXIDATIVE STRESS AND MITOCHONDRIAL DYNAMICS MALFUNCTION ARE LINKED IN PELIZAEUS-MERZBACHER DISEASE. Brain Pathol. 2017;: pubmed publisher
    ..identified redox imbalance, with altered antioxidant defense and oxidative damage to several enzymes involved in ATP production, such as glycolytic enzymes, creatine kinase and mitochondrial proteins from the Krebs cycle and ..
  63. Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, et al. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochim Biophys Acta. 2013;1831:1134-45 pubmed publisher
    b>ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux and thereby inhibits lipid-laden macrophage/foam cell formation and atherosclerosis...
  64. Devi S, Chichili V, Jeyakanthan J, Velmurugan D, Sivaraman J. Structural basis for the hydrolysis of ATP by a nucleotide binding subunit of an amino acid ABC transporter from Thermus thermophilus. J Struct Biol. 2015;190:367-72 pubmed publisher
    b>ATP-binding cassette (ABC) transporters are a major family of small molecule transporter proteins, and their deregulation is associated with several diseases, including cancer...
  65. Ashcroft F, Puljung M, Vedovato N. Neonatal Diabetes and the KATP Channel: From Mutation to Therapy. Trends Endocrinol Metab. 2017;28:377-387 pubmed publisher
    Activating mutations in one of the two subunits of the ATP-sensitive potassium (KATP) channel cause neonatal diabetes (ND)...
  66. Lee J, Kosaras B, Del Signore S, Cormier K, McKee A, Ratan R, et al. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta Neuropathol. 2011;121:487-98 pubmed publisher
    ..NDGA also protected cultured neurons against oxidative stress-induced cell death by improving ATP generation and mitochondrial morphology and function...
  67. Burnstock G. Blood cells: an historical account of the roles of purinergic signalling. Purinergic Signal. 2015;11:411-34 pubmed publisher
    ..The release of ATP and the expression of purinoceptors and ectonucleotidases on erythrocytes in health and disease are reviewed...
  68. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, et al. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016;30:1956-70 pubmed publisher
    Increased lipid synthesis is a key characteristic of many cancers that is critical for cancer progression. ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, is frequently overexpressed or activated in cancer to promote lipid ..
  69. Yoon C, Jung H, Goo K, Moon S, Koo K, Lee N, et al. Low-Intensity Ultrasound Modulates Ca2+ Dynamics in Human Mesenchymal Stem Cells via Connexin 43 Hemichannel. Ann Biomed Eng. 2018;46:48-59 pubmed publisher
    ..that ultrasound exposure triggers opening of connexin 43 hemichannels on the plasma membrane, causing release of ATP into the extracellular space...
  70. Caporizzo M, Fishman C, Sato O, Jamiolkowski R, Ikebe M, Goldman Y. The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility. Biophys J. 2018;114:1400-1410 pubmed publisher
    ..processivity on fascin-bundled actin and are only weakly processive on single actin filaments below saturating [ATP]...
  71. Hopfner K, Tainer J. Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures. Curr Opin Struct Biol. 2003;13:249-55 pubmed
    b>ATP-binding cassette (ABC)-type ATPases are chemo-mechanical engines for diverse biological pathways...
  72. Damas J, Oliveira A, Baptista A, Soares C. Structural consequences of ATP hydrolysis on the ABC transporter NBD dimer: molecular dynamics studies of HlyB. Protein Sci. 2011;20:1220-30 pubmed publisher
    ..are the nucleotide binding domains (NBDs), which form a dimer responsible for the binding and hydrolysis of ATP, concomitantly with substrate translocation...
  73. Ranjan A, Wang F, Mizuguchi G, Wei D, Huang Y, Wu C. H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast. elife. 2015;4:e06845 pubmed publisher
    ..Our findings provide new molecular insights on recognition of the canonical nucleosome by a chromatin remodeler and have implications for ATP-driven mechanisms of histone eviction and deposition.
  74. Tsai H, Lin R, Hsieh T. Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity. J Biomed Sci. 2016;23:38 pubmed publisher
    ..with a significant reduction in the mitochondrial DNA copy number, the mitochondrial membrane potential, and ATP content compared with those of both wildtype and transgene-rescued flies of the same age...
  75. Li S, Peng W, Li J, Hao G, Geng X, Sun J. Characterization of Japanese flounder (Paralichthys olivaceus) Caspase1 involved in extracellular ATP-mediated immune signaling in fish. Fish Shellfish Immunol. 2017;67:536-545 pubmed publisher
    ..several teleost caspase1 genes have been identified, their partner proteins and implication in extracellular ATP-mediated immune signaling in fish are still very limited...
  76. Manni S, Carrino M, Piazza F. Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways. J Hematol Oncol. 2017;10:157 pubmed publisher
    ..generated by the increased activity of CK1α and CK2 in multiple myeloma contributes to malignant plasma cell proliferation and survival and represents an Achilles' heel for the activity of small ATP competitive CK1α or CK2 inhibitors.
  77. Fois G, Winkelmann V, Bareis L, Staudenmaier L, Hecht E, Ziller C, et al. ATP is stored in lamellar bodies to activate vesicular P2X4 in an autocrine fashion upon exocytosis. J Gen Physiol. 2018;150:277-291 pubmed publisher
    ..Subsequent activation of P2X4 receptors by adenosine triphosphate (ATP) results in local fusion-activated cation entry (FACE), facilitating fusion pore dilation, surfactant secretion, ..
  78. Yokoshiki H, Sunagawa M, Seki T, Sperelakis N. Antisense oligodeoxynucleotides of sulfonylurea receptors inhibit ATP-sensitive K+ channels in cultured neonatal rat ventricular cells. Pflugers Arch. 1999;437:400-8 pubmed
    To identify the functional sulfonylurea receptor (SUR), a subunit of the adenosine 5'-triphosphate (ATP)-sensitive K+ (KATP) channels, in neonatal rat ventricular cells, such cells in primary culture were treated for 6 days with ..
  79. Nelp M, Bandarian V. A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate. Angew Chem Int Ed Engl. 2015;54:10627-9 pubmed publisher
    ..This is subsequently dehydrated to form the nitrile in a process that consumes a second equivalent of ATP. The authentic amide intermediate is shown to be chemically and kinetically competent...
  80. Head S, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, et al. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. Proc Natl Acad Sci U S A. 2015;112:E7276-85 pubmed publisher
    ..Inhibition of VDAC1 by itraconazole disrupts mitochondrial metabolism, leading to an increase in the cellular AMP:ATP ratio and activation of the AMP-activated protein kinase (AMPK), an upstream regulator of mTOR...
  81. Dai F, Lee H, Zhang Y, Zhuang L, Yao H, Xi Y, et al. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A. 2017;114:3192-3197 pubmed publisher
    ..BAP1 inhibits glucose deprivation-induced reactive oxygen species and ATP depletion, two cellular events contributing to the ER stress-induced cell death...
  82. Hu W, Coomer T, Loka D, Oosterhuis D, Zhou Z. Potassium deficiency affects the carbon-nitrogen balance in cotton leaves. Plant Physiol Biochem. 2017;115:408-417 pubmed publisher
    ..K deficiency also induced lower soluble protein content in leaves. Leaf ATP level was significantly increased under K deficiency, indicating ATP utilization was lower, so that less energy was ..
  83. Sarzynski M, Ruiz Ramie J, Barber J, Slentz C, Apolzan J, McGarrah R, et al. Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function. Arterioscler Thromb Vasc Biol. 2018;38:943-952 pubmed publisher
    ..4 to -8.4%; SEM, 0.06). In E-MECHANIC, non-ABCA1 (ATP-binding cassette transporter A1) radiolabeled efflux significantly increased 5.7% (95% CI, 1.2-10...
  84. Kota S, Meher L, Jammula S, Kota S, Modi K. Genetics of type 2 diabetes mellitus and other specific types of diabetes; its role in treatment modalities. Diabetes Metab Syndr. 2012;6:54-8 pubmed publisher
    ..Previous studies indicated that variants in genes encoding the pancreatic ?-cell K+ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) are associated with neonatal diabetes...
  85. Tollefsen K, Song Y, Kleiven M, Mahrosh U, Meland S, Rosseland B, et al. Transcriptional changes in Atlantic salmon (Salmo salar) after embryonic exposure to road salt. Aquat Toxicol. 2015;169:58-68 pubmed publisher
    ..Biomarkers for osmoregulatory responses such as atp1a2, the gene encoding the main sodium/potassium ATP-fueled transporter for chloride ions, and txdc9, a gene involved in regulation of cell redox homeostasis (oxidative ..
  86. Saha D, Heldt C, Gencoglu M, Vijayaragavan K, Chen J, Saksule A. A study on the cytotoxicity of carbon-based materials. Mater Sci Eng C Mater Biol Appl. 2016;68:101-108 pubmed publisher
    ..by reactive oxygen species (ROS) detection, cellular metabolic activity measurement by adenosine triphosphate (ATP) depletion and visualization of cellular internalization by TEM imaging...
  87. Torsoni M, Borges B, Cote J, Allen S, Mahany E, García Galiano D, et al. AMPK?2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice. Endocrinology. 2016;157:4803-4816 pubmed
    ..The AMP-activated protein kinase (AMPK) works as a cellular sensor of the AMP to ATP ratio and ultimately of energy availability...
  88. Zulazmi N, Gopalsamy B, Min J, Farouk A, Sulaiman M, Bharatham B, et al. Zerumbone Alleviates Neuropathic Pain through the Involvement of l-Arginine-Nitric Oxide-cGMP-K⁺ ATP Channel Pathways in Chronic Constriction Injury in Mice Model. Molecules. 2017;22: pubmed publisher
    The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K⁺ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced ..
  89. Nagashima K, Watanabe I, Okumura Y, Iso K, Takahashi K, Watanabe R, et al. High-voltage zones within the pulmonary vein antra: Major determinants of acute pulmonary vein reconnections after atrial fibrillation ablation. J Interv Card Electrophysiol. 2017;49:137-145 pubmed publisher
    ..amplitude recorded from the PV-LA junction and acute post-PVI PV reconnections (spontaneous PV reconnections and/or ATP-provoked dormant PV conduction)...
  90. Togo T. Cell membrane disruption stimulates cAMP and Ca2+ signaling to potentiate cell membrane resealing in neighboring cells. Biol Open. 2017;6:1814-1819 pubmed publisher
    ..Furthermore, inhibition of PKA and PKC suppressed the ATP-mediated short-term potentiation of membrane resealing in neighboring cells...
  91. Viano M, Alotto D, Aillon A, Castagnoli C, Silvagno F. A thermal gradient modulates the oxidative metabolism and growth of human keratinocytes. FEBS Open Bio. 2017;7:1843-1853 pubmed publisher
    ..At 33 °C, the increased mitochondrial ATP synthesis was associated with a strong induction of the modulator of the respiratory chain estrogen receptor ?, ..
  92. Geldenhuys W, Bergeron S, Mullins J, Aljammal R, Gaasch B, Chen W, et al. High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor. Bioorg Med Chem Lett. 2017;27:2029-2037 pubmed publisher
    ..We provide a putative model for increased phosphate transfer in the ATP binding domain when compound 1 is virtually docked with DAPK1...