ATP5F1A

Summary

Gene Symbol: ATP5F1A
Description: ATP synthase F1 subunit alpha
Alias: ATP5A, ATP5A1, ATP5AL2, ATPM, COXPD22, HEL-S-123m, MC5DN4, MOM2, OMR, ORM, hATP1, ATP synthase subunit alpha, mitochondrial, ATP synthase alpha chain, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2, ATP sythase (F1-ATPase) alpha subunit, epididymis secretory sperm binding protein Li 123m, mitochondrial ATP synthetase, oligomycin-resistant
Species: human
Products:     ATP5F1A

Top Publications

  1. Kikusato M, Muroi H, Uwabe Y, Furukawa K, Toyomizu M. Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α. Anim Sci J. 2016;87:1371-1378 pubmed publisher
    ..PGC-1α), nuclear respiratory factor-1 (NRF1), mitochondrial transcription factor A (TFAM) and ATP5a1 (a component of mitochondrial adenosine triphosphate synthase) gene expression and cytochrome c oxidase activity, ..
  2. Grillo S, Koulen P. Psychophysical testing in rodent models of glaucomatous optic neuropathy. Exp Eye Res. 2015;141:154-63 pubmed publisher
    ..Such a combination of the experimental assessment of the optokinetic reflex (OKR) or optomotor response (OMR) with other measures of retinal structure and function is especially valuable for research on GON...
  3. Schütz R, Kuratli K, Richard N, Stoll C, Schwager J. Mitochondrial and glycolytic activity of UV-irradiated human keratinocytes and its stimulation by a Saccharomyces cerevisiae autolysate. J Photochem Photobiol B. 2016;159:142-8 pubmed publisher
    ..Particularly, gene expression of SHDA, UPC2, BID, and ATP5A1 was reduced about twofold within 4h...
  4. Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, et al. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. Epilepsy Res. 2017;136:18-34 pubmed publisher
    ..On the other hand, blockade of ?2C-adrenoceptors using the receptor subtype-specific antagonist ORM-12741 had no favorable effects on the post-TBI outcome...
  5. Podrini C, Koffas A, Chokshi S, Vinciguerra M, Lelliott C, White J, et al. MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. FASEB J. 2015;29:1676-87 pubmed publisher
    ..The result was supported by a high positivity for macroH2A1.1 in knockout mice for genes targeted by macroH2A1 (Atp5a1 and Fam73b), that under a high-fat diet presented minimal lipidosis...
  6. Ren L, Ding S, Song Y, Li B, Ramanathan M, Co J, et al. Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication. J Biol Chem. 2019;294:5993-6006 pubmed publisher
    ..Functionally, siRNA-mediated genetic depletion of ATP5B or other ATP synthase subunits such as ATP5A1 and ATP5O reduced the production of infectious viral progeny without significant alteration of intracellular viral ..
  7. Luo W, Liu C, Cao X, Huang S, Wang W, Wang Y. Transcriptome Profile Analysis of Ovarian Tissues from Diploid and Tetraploid Loaches Misgurnus anguillicaudatus. Int J Mol Sci. 2015;16:16017-33 pubmed publisher
    ..acute regulatory protein (StAR), mitogen-activated protein kinase 14a (MAPK14a), ATP synthase subunit alpha (atp5a), and synaptonemal complex protein 1 (Scp1), were involved in regulation of cell proliferation, division, gene ..
  8. Wu C, Xu G, Tsai S, Freed W, Lee C. Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections. Biochem Biophys Res Commun. 2017;482:282-288 pubmed publisher
    ..energy, and amino acid metabolism pathways (NDUFS1, NDUFA10, NDUFB4, NDUFB5, NDUFA5, NDUFB10, SDHB, SDHC, ATP5H, ATP5A, and ATP5J)...
  9. Cao T, Fan S, Zheng D, Wang G, Yu Y, Chen R, et al. Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion. Basic Res Cardiol. 2019;114:17 pubmed publisher
    ..Furthermore, transgenic up-regulation of mitochondria-targeted CAPN1 induced a reduction of ATP5A1 protein and ATP synthase activity in hearts...

More Information

Publications163 found, 100 shown here

  1. Zhang Y, Zhang Y, Feng C, Wu Y, Liu A, Sheng J, et al. Comparative proteomic analysis of human placenta derived from assisted reproductive technology. Proteomics. 2008;8:4344-56 pubmed publisher
    ..to be differentially expressed in both ART groups were identified as annexin A3, hnRNP C1/C2, alpha-SNAP, FTL and ATP5A. Some of the proteins were confirmed by Western blot and immunohistochemistry analysis...
  2. Voillet V, San Cristobal M, Père M, Billon Y, Canario L, Liaubet L, et al. Integrated Analysis of Proteomic and Transcriptomic Data Highlights Late Fetal Muscle Maturation Process. Mol Cell Proteomics. 2018;17:672-693 pubmed publisher
    ..Some proteins, including ATP5A1 and CKMT2, were important nodes in the network related to muscle metabolism...
  3. Lucas E, Dougherty S, McMeekin L, Reid C, Dobrunz L, West A, et al. PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons. J Neurosci. 2014;34:14375-87 pubmed publisher
    ..O subunit (Atp5o), phytanol-CoA-2hydroxylase (Phyh), and ATP synthase mitrochondrial F1 complex α subunit 1 (Atp5a1)] functions...
  4. Tapia Limonchi R, Díaz I, Cahuana G, Bautista M, Martin F, Soria B, et al. Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells. Islets. 2014;6:e995997 pubmed publisher
    ..These include stress response mitochondrial proteins (UQCRC2, VDAC1, ATP5C1, ATP5A1) in RINm5F cells and stress response endoplasmic reticulum proteins (HSPA5, PDIA6, VCP, GANAB) in HPI...
  5. Chomova M, Balazova M, Muchova J. Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet. Mol Cell Biochem. 2017;435:109-131 pubmed publisher
    ..in the protein expression of the regulatory COX4 subunit of cytochrome c oxidase, in the inhibitory factor IF1 and ATP5A subunit of F0F1-ATP synthase, in the uncoupling protein UCP4 and supramolecular organization ..
  6. Zhou Z, Ju H, Sun M, Chen H, Ji H, Jiang D, et al. Serum fetuin-A concentrations are positively associated with serum VEGF levels in patients with newly diagnosed type 2 diabetes. Endocr J. 2015;62:879-85 pubmed publisher
    ..concentrations of fetuin-A with high levels of VEGF is higher than that with low levels of VEGF (odds ratio of M-H [ORM-H], 2.938; 95% confidence interval [CI], 1.896-4.553)...
  7. Flück M, Li R, Valdivieso P, Linnehan R, Castells J, Tesch P, et al. Early changes in costameric and mitochondrial protein expression with unloading are muscle specific. Biomed Res Int. 2014;2014:519310 pubmed publisher
    ..to fibre typing and measures for costameric (FAK and FRNK), mitochondrial (NDUFA9, SDHA, UQCRC1, UCP3, and ATP5A1), and MHCI protein and RNA content...
  8. Tang Y, Mi C, Liu J, Gao F, Long J. Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol. 2014;23:101-6 pubmed publisher
    ..01 for NDUFS3, P=.068 for SDHB, and P<.05 for ATP5A1). Mitochondrial fission protein Drp1 was decreased (P<.05), while fusion protein OPA1 was increased (P<.01)...
  9. Serrano C, Cuevas Córdoba B, Macías Segura N, González Curiel R, Martínez Balderas V, Enciso Moreno L, et al. Transcriptional profiles discriminate patients with pulmonary tuberculosis from non-tuberculous individuals depending on the presence of non-insulin diabetes mellitus. Clin Immunol. 2016;162:107-17 pubmed publisher
    ..Genes expressed in blood, with inflammatory related functions were evaluated in humans by RT-qPCR. NCF1 and ORM transcripts have the better discriminatory capacity to identify PTB subjects from LTBI and non-infected controls (..
  10. Yusenko M, Ruppert T, Kovacs G. Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis. Int J Biol Sci. 2010;6:213-24 pubmed
    ..In chromophobe RCCs downregulation of ATP5A1, the alpha subunit of complex V, has been observed, but no changes in expression of other complexes of the ..
  11. Zhong Y, Zhang J, Yu H, Zhang J, Sun X, Chen W, et al. Characterization and sub-cellular localization of GalNAc-binding proteins isolated from human hepatic stellate cells. Biochem Biophys Res Commun. 2015;468:906-12 pubmed publisher
    ..For example, the GNBPs (i.e. BTF3, COX17, and ATP5A1) responsible for the regulation of protein binding were up-regulated, and those (i.e...
  12. Sherkhane P, Kapfhammer J. Chronic pharmacological blockade of the Na+ /Ca2+ exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures. Eur J Neurosci. 2017;46:2108-2120 pubmed publisher
    ..We have used additional NCX inhibitors including CB-DMB, ORM-10103, SEA0400, YM-244769, and SN-6 which have higher specificity for NCX isoforms and target either the forward, ..
  13. Zhang M, Zakhartchouk A. Characterization of the interactome of the porcine reproductive and respiratory syndrome virus glycoprotein-5. Arch Virol. 2018;163:1595-1605 pubmed publisher
    ..Interaction between GP5 and ATP synthase subunit alpha (ATP5A) was further confirmed by co-immunoprecipitation suggesting a possible role of GP5 in regulation of ATP production ..
  14. Hoxha S, Kaya Sezginer E, Bakar Ates F, Kokturk O, Toygar Memikoğlu U. Effect of semi-rapid maxillary expansion in children with obstructive sleep apnea syndrome: 5-month follow-up study. Sleep Breath. 2018;22:1053-1061 pubmed publisher
    ..There was a significant increase in serum orosomucoid (ORM)2 levels and a decrease in urine perlecan levels in the control group after a 5-month follow-up...
  15. Jadhav S, Russo S, Cowart L, Greenberg M. Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine. J Biol Chem. 2017;292:4953-4959 pubmed publisher
    ..Expression of ORM genes (negative regulators of PHS synthesis) and of fatty acid elongase genes FEN1 and SUR4 were ..
  16. Qattan A, Radulovic M, Crawford M, Godovac Zimmermann J. Spatial distribution of cellular function: the partitioning of proteins between mitochondria and the nucleus in MCF7 breast cancer cells. J Proteome Res. 2012;11:6080-101 pubmed publisher
    ..g., NDUFA5, NDUFB10, NDUFS1, NDUF2, SDHA, UQRB, UQRC2, UQCRH, COX5A, COX5B, MT-CO2, ATP5A1, ATP5B, ATP5H, etc.), from the TCA-cycle (DLST, IDH2, IDH3A, OGDH, SUCLAG2, etc...
  17. Pujhari S, Zakhartchouk A. Porcine reproductive and respiratory syndrome virus envelope (E) protein interacts with mitochondrial proteins and induces apoptosis. Arch Virol. 2016;161:1821-30 pubmed publisher
    ..In this study, we present evidence for the interaction of the E protein with mitochondrial proteins ATP5A (part of ATP synthase complex), prohibitin, and ADP/ATP translocase...
  18. Cheng L, Li B, Chen X, Su J, Wang H, Yu S, et al. CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1? activation. Biochem Biophys Res Commun. 2016;477:685-691 pubmed publisher
    ..production and increased the activities of endogenous antioxidant enzymes, the expression of PGC-1?, NRF1, TFAM, ATP5A1 and SIRT1, and the activity of cytochrome c oxidase, indicating an induction of mitochondrial biogenesis...
  19. Yajima Y, Hiratsuka T, Kakimoto Y, Ogawa S, Shima K, Yamazaki Y, et al. Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue. Sci Rep. 2018;8:7493 pubmed publisher
    ..As a result, IMS signals of mitochondrial adenosine triphosphate synthase alpha subunit (ATP5A), myosin-6/7(MYH6/7), aortic actin, and the myosin light chain 3 (MYL3) were identified in the infarcted region...
  20. Martínez Montañés F, Lone M, Hsu F, Schneiter R. Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether. J Lipid Res. 2016;57:2040-2050 pubmed
    ..SPT activity is negatively regulated by Orm proteins to prevent the toxic overaccumulation of LCBs...
  21. Sadeesh E, Fozia S, Meena K. Combined positive effect of oocyte extracts and brilliant cresyl blue stained recipient cytoplasts on epigenetic reprogramming and gene expression in buffalo nuclear transfer embryos. Cytotechnology. 2017;69:289-305 pubmed publisher
    ..The RA of NASP, EEF1A1, DNMT1, ODC1 and RPS27A was increased (P < 0.05) in BCB+ oocytes, whereas ATP5A1 and S100A10 increased (P < 0.05) in BCB- oocytes...
  22. Martínez Montañés F, Schneiter R. Following the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry. J Lipid Res. 2016;57:906-15 pubmed publisher
    ..In support of this notion, we show that mutants lacking the Orm proteins, regulators of the rate-limiting step of the pathway, display increased steady-state levels of these ..
  23. Mighdoll M, Tao R, Kleinman J, Hyde T. Myelin, myelin-related disorders, and psychosis. Schizophr Res. 2015;161:85-93 pubmed publisher
    ..we outline the evidence from a number of both clinically-based and post-mortem studies that provide evidence that OMR genes are genetically associated with increased risk for schizophrenia...
  24. Brosse A, Korobeinikova A, Gottesman S, Guillier M. Unexpected properties of sRNA promoters allow feedback control via regulation of a two-component system. Nucleic Acids Res. 2016;44:9650-9666 pubmed
    ..This control of ompR-envZ by the Omr sRNAs does not affect the amount of phosphorylated OmpR, i.e. the presumably active form of the regulator...
  25. Balderas I, Rodriguez Ortiz C, Bermudez Rattoni F. Consolidation and reconsolidation of object recognition memory. Behav Brain Res. 2015;285:213-22 pubmed publisher
    ..review, we will present evidence that shows that the perirhinal cortex is also necessary for reconsolidation of ORM; the destabilization/re-stabilization memory process upon its activation...
  26. Perdices E, Cañas J. SDVL: Efficient and Accurate Semi-Direct Visual Localization. Sensors (Basel). 2019;19: pubmed publisher
    ..Additionally, an outlier rejection mechanism (ORM) has been implemented to rule out misplaced features, improving accuracy especially in partially dynamic ..
  27. Abrahamson M, Hooker E, Ajami N, Petrosino J, Orwoll E. Successful collection of stool samples for microbiome analyses from a large community-based population of elderly men. Contemp Clin Trials Commun. 2017;7:158-162 pubmed publisher
    ..samples on a large number of community dwelling elderly men using the OMNIgene-GUT stool/feces collection kit (OMR-200, DNA Genotek, Ottawa, Canada)...
  28. Zhang Y, Zhang G, Shang Q. Computer-Aided Clinical Trial Recruitment Based on Domain-Specific Language Translation: A Case Study of Retinopathy of Prematurity. J Healthc Eng. 2017;2017:7862672 pubmed publisher
    ..Then the production rule is translated to an intermediate query-oriented DSL (e.g., LINQ). Finally, the intermediate DSL is directly mapped to native database queries (e.g., SQL) automated by ORM (object-relational mapping).
  29. Rinne J, Wesnes K, Cummings J, Hakulinen P, Hallikainen M, Hänninen J, et al. Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease. Alzheimers Dement (N Y). 2017;3:1-9 pubmed publisher
    b>ORM-12741 is a novel selective antagonist of alpha-2C adrenoceptors. This trial evaluated the safety and efficacy of ORM-12741 in patients with Alzheimer's disease (AD).
  30. Staufenbiel I, Adam K, Deac A, Geurtsen W, Günay H. Influence of fruit consumption and fluoride application on the prevalence of caries and erosion in vegetarians--a controlled clinical trial. Eur J Clin Nutr. 2015;69:1156-60 pubmed publisher
    ..index and the number of teeth with dental erosion (DE), root caries (RC) and overhanging restoration margins (ORM) were recorded...
  31. Savolainen K, Ihalainen J, Jalkanen A, Forsberg M. Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats. Psychopharmacology (Berl). 2018;: pubmed publisher
    ..deficits in male Wistar rats and then used this model to compare the effects of an α2C AR antagonist (ORM-13070 0.3 and 1.0 mg/kg s.c.) with an α7 nAChR partial agonist (EVP-6124 0.3 mg/kg s.c...
  32. Módis K, Ju Y, Ahmad A, Untereiner A, Altaany Z, Wu L, et al. S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics. Pharmacol Res. 2016;113:116-124 pubmed publisher
    ..Using a biotin switch assay, we have detected S-sulfhydration of the ? subunit (ATP5A1) of ATP synthase in response to exposure to H2S in vitro...
  33. Sulochana S, Saini N, Daram P, Polina S, Mullangi R. Validation of an LC-MS/MS method for simultaneous quantitation of enzalutamide, N-desmethylenzalutamide, apalutamide, darolutamide and ORM-15341 in mice plasma and its application to a mice pharmacokinetic study. J Pharm Biomed Anal. 2018;156:170-180 pubmed publisher
    ..of enzalutamide, N-desmethylenzalutamide (active metabolite of enzalutamide), apalutamide, darolutamide and ORM-15341 (active metabolite of darolutamide) in mice plasma as per regulatory guidelines...
  34. Lehto J, Johansson J, Vuorilehto L, Luoto P, Arponen E, Scheinin H, et al. Sensitivity of [(11)C]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects. Psychopharmacology (Berl). 2015;232:4169-78 pubmed publisher
    ..The objective of this study is to test the sensitivity of [(11)C]ORM-13070 uptake to increased concentrations of extracellular (synaptic) noradrenaline in the human brain...
  35. Koc E, Hacıosmanoğlu E, Claudio P, Wolf A, Califano L, Friscia M, et al. Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma. Mitochondrion. 2015;24:113-21 pubmed publisher
    ..blot analyses of the several stage IVA HNSCC primary tumors have shown reduction in the expression of COII and ATP5A of the OXPHOS complexes IV and V subunits, respectively...
  36. Siow D, Sunkara M, Morris A, Wattenberg B. Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. Adv Biol Regul. 2015;57:42-54 pubmed publisher
    ..The three ORMDL proteins are membrane proteins of the endoplasmic reticulum related to the yeast Orm proteins, which have been shown to be homeostatic regulators of SPT...
  37. Xing X, Ma X, Men J, Chen Y, Guo S. Phylogenetic constrains on mycorrhizal specificity in eight Dendrobium (Orchidaceae) species. Sci China Life Sci. 2017;60:536-544 pubmed publisher
    Plant phylogeny constrains orchid mycorrhizal (OrM) fungal community composition in some orchids...
  38. Kim D, Kim K, Yoo B, Hong S, Lim Y, Shin Y, et al. Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells. Cancer Sci. 2008;99:1884-91 pubmed publisher
    ..In the presence of cell cycle synchronizing drugs, doxorubicin, etoposide, or nocodazole, suppression of galectin-3 induced cell cycle progression to G0/G1 phase. ..
  39. Zhao L, Morgan T, Mao Z, Lin S, Cadenas E, Finch C, et al. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS ONE. 2012;7:e31267 pubmed publisher
    ..Genes involved in mitochondrial energy (ATP synthase ? subunit; Atp5a1), redox homeostasis (peroxiredoxin 5; Prdx5), insulin signaling (insulin-like growth factor I; Igf1), and ..
  40. Shi C, Yuan X, Chang K, Cho K, Xie X, Chen D, et al. Optimization of Optomotor Response-based Visual Function Assessment in Mice. Sci Rep. 2018;8:9708 pubmed publisher
    Optomotor response/reflex (OMR) assays are emerging as a powerful and versatile tool for phenotypic study and new drug discovery for eye and brain disorders. Yet efficient OMR assessment for visual performance in mice remains a challenge...
  41. Li C, Yang L, Kong J. Cognitive factors associated with the willingness for HIV testing among pregnant women in China. Chin Med J (Engl). 2014;127:3423-7 pubmed
    ..60%. Perceived higher susceptibility to HIV (multivariate-adjusted odds ratio (ORm) = 2.02, 95% confidence interval (CI): 1.40-5.06), more knowledge for HIV (ORm = 1.92, 95% CI: 1.11-3...
  42. Wang Z, Li D, Lau J, Yang X, Shen H, Cao W. Prevalence and associated factors of inhaled nitrites use among men who have sex with men in Beijing, China. Drug Alcohol Depend. 2015;149:93-9 pubmed publisher
    ..8% among those with awareness about the compounds. A stepwise model found that age group (26-35 years old, ORm= 3.91; ≤ 25 years old, ORm = 3.05; reference group: >35 years old, P < 0...
  43. Caperna T, Shannon A, Stoll M, Blomberg L, Ramsay T. Regulation of alpha-1 acid glycoprotein synthesis by porcine hepatocytes in monolayer culture. Domest Anim Endocrinol. 2015;52:51-9 pubmed publisher
    Alpha-1 acid glycoprotein (AGP, orosomucoid, ORM-1) is a highly glycosylated mammalian acute-phase protein, which is synthesized primarily in the liver and represents the major serum protein in newborn pigs...
  44. Kabir S, Stallard S, Weiler Mithoff E, Mansell J, Mallon E, Doughty J, et al. Six-year follow-up of patients treated with oncoplastic reduction mammoplasty: A cohort study. Int J Surg. 2016;26:38-42 pubmed publisher
    ..Hence, we report long-term recurrence rates in patients treated with oncoplastic reduction mammoplasty (ORM). A prospectively maintained database was searched to identify patients who underwent ORM between 2005 and 2010...
  45. Miranda García P, Chaparro M, Gisbert J. Correlation between serological biomarkers and endoscopic activity in patients with inflammatory bowel disease. Gastroenterol Hepatol. 2016;39:508-15 pubmed publisher
    ..Serum concentrations of different biomarkers (C-reactive protein [CRP], orosomucoid [ORM], erythrocyte sedimentation rate [ESR], fibrinogen, platelets, leukocytes, neutrophils and hemoglobin [Hb]) were ..
  46. Penington J, Penno M, Ngui K, Ajami N, Roth Schulze A, Wilcox S, et al. Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis. Sci Rep. 2018;8:4386 pubmed publisher
    ..collected from six individuals on three consecutive days were placed in commercial collection tubes (OMNIgeneGut OMR-200) or in sterile screw-top tubes in a home fridge or home freezer for 6-24?h, before transfer and storage at -80?..
  47. Wu L, Jiang Y, Zhu J, Wen Z, Xu X, Xu X, et al. Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse. Brain Res Bull. 2014;109:88-98 pubmed publisher
    ..Among the 15 genes, orosomucoid (Orm) 1 was most sharply changed, and this gene has previously been reported to maintain the permeability of ..
  48. Bhattacharjee A, Hasanain M, Kathuria M, Singh A, Datta D, Sarkar J, et al. Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK. Sci Rep. 2018;8:2303 pubmed publisher
    ..Here, we show that Ormeloxifene (ORM), a selective estrogen receptor modulator approved for oral contraceptive use induces autophagic flux in ovarian ..
  49. Sánchez de Madariaga R, Muñoz A, Castro A, Moreno O, Pascual M. Executing Complexity-Increasing Queries in Relational (MySQL) and NoSQL (MongoDB and EXist) Size-Growing ISO/EN 13606 Standardized EHR Databases. J Vis Exp. 2018;: pubmed publisher
    ..EHR extracts, in three different database management systems (DBMS): relational MySQL object-relational mapping (ORM), document-based NoSQL MongoDB, and native extensible markup language (XML) NoSQL eXist...
  50. Lieber D, Calvo S, Shanahan K, Slate N, Liu S, Hershman S, et al. Targeted exome sequencing of suspected mitochondrial disorders. Neurology. 2013;80:1762-70 pubmed publisher
    ..In one case, we modeled patient mutations in yeast to provide evidence that recessive mutations in ATP5A1 can underlie combined respiratory chain deficiency...
  51. Löser S, Gregory L, Zhang Y, Schaefer K, Walker S, Buckley J, et al. Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease. J Allergy Clin Immunol. 2017;139:1496-1507.e3 pubmed publisher
    Genome-wide association studies have identified the ORM (yeast)-like protein isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk factor for childhood-onset asthma...
  52. Lage R, Moscoso I, Fernández Trasancos Ã, Cebro M, Couselo M, Fandiño Vaquero R, et al. Differential behaviour of epicardial adipose tissue-secretomes with high and low orosomucoid levels from patients with cardiovascular disease in H9C2 cells. Mol Cell Endocrinol. 2015;416:77-87 pubmed publisher
    Epicardial adipose tissue releases orosomucoid (ORM), an acute phase protein with multiple modulatory and protective properties. We aimed to identify the effect of EAT-supernatants according to their ORM levels on H9C2 cells...
  53. Cheng H, Whang L, Wu S. Enhanced bioenergy recovery from oil-extracted microalgae residues via two-step H2/CH4 or H2/butanol anaerobic fermentation. Biotechnol J. 2016;11:375-83 pubmed publisher
    ..Anaerobic processes can be used for treating oil-extracted microalgae residues (OMR) and at the same time for recovering bioenergy...
  54. Jo M, Kim J, Song G, Seo M, Hwang E, Suk K. Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation. J Neurosci. 2017;37:2878-2894 pubmed publisher
    Orosomucoid (ORM) is an acute-phase protein that belongs to the immunocalin subfamily, a group of small-molecule-binding proteins with immunomodulatory functions. Little is known about the role of ORM proteins in the CNS...
  55. Pereira L, Guimaraes I, Oliveira V, Bastos C, Ribeiro F, Prado V, et al. Estradiol effect on short-term object memory under hypocholinergic condition. Brain Res Bull. 2018;140:411-417 pubmed publisher
    Estrogens positively affect object recognition memory (ORM). However, whether this effect rely on acetylcholine is unknown...
  56. Finnema S, Hughes Z, Haaparanta Solin M, Stepanov V, Nakao R, Varnäs K, et al. Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..We explored the use of the novel α2C-adrenoceptor antagonist PET tracer [(11)C]ORM-13070 for measurement of amphetamine-induced changes in synaptic norepinephrine...
  57. Nakamura K, Ito I, Kobayashi M, Herndon D, Suzuki F. Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype. Cytokine. 2015;73:8-15 pubmed publisher
    Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities...
  58. Sun Y, Yang Y, Qin Z, Cai J, Guo X, Tang Y, et al. The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway. Diabetes. 2016;65:1630-41 pubmed publisher
    The acute-phase protein orosomucoid (ORM) exhibits a variety of activities in vitro and in vivo, notably modulation of immunity and transportation of drugs...
  59. Rossato J, Köhler C, Radiske A, Lima R, Bevilaqua L, Cammarota M. State-dependent effect of dopamine D₁/D₅ receptors inactivation on memory destabilization and reconsolidation. Behav Brain Res. 2015;285:194-9 pubmed publisher
    Object recognition memories (ORM) can incorporate new information upon reactivation...
  60. Brüggemann M, Gromes A, Poss M, Schmidt D, Klümper N, Tolkach Y, et al. Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma. Transl Oncol. 2017;10:661-668 pubmed publisher
    ..Differential expression was validated exemplarily for 12 genes (ATP5A1, ATP5B, ATPAF1, ATP5C1, ATP5D, ATP5O, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5I, ATP5S; screening cohort ccRCC n=18 ..
  61. Mihaila S, Muraru D, Miglioranza M, Piasentini E, Aruta P, Cucchini U, et al. Relationship between mitral annulus function and mitral regurgitation severity and left atrial remodelling in patients with primary mitral regurgitation. Eur Heart J Cardiovasc Imaging. 2016;17:918-29 pubmed publisher
    ..regurgitation (MR) severity, left ventricular (LV) and atrial (LA) size and function in patients with organic MR (OMR)...
  62. Davis D, Kannan M, Wattenberg B. Orm/ORMDL proteins: Gate guardians and master regulators. Adv Biol Regul. 2018;70:3-18 pubmed publisher
    ..Finally, we discuss the intriguing connection between one of the mammalian ORMDL isoforms, ORMDL3, and the pervasive pulmonary disease, asthma, in humans. ..
  63. Dittakavi S, Nagasuri P, Sulochana S, Saim S, Mallurwar S, Zainuddin M, et al. LC-MS/MS-ESI method for simultaneous quantification of darolutamide and its active metabolite, ORM-15341 in mice plasma and its application to a pharmacokinetic study. J Pharm Biomed Anal. 2017;145:454-461 pubmed publisher
    ..e. ORM-15341 in 50?L mice plasma using bicalutamide as an internal standard (I.S.) as per regulatory guidelines...
  64. Matsuo M, Ando Y, Kamei Y, Fukamachi S. A semi-automatic and quantitative method to evaluate behavioral photosensitivity in animals based on the optomotor response (OMR). Biol Open. 2018;7: pubmed publisher
    The optomotor response (OMR) is a locomotor behavior of animals that is induced by moving repetitive visual stimuli. This characteristic helps animals particularly when stabilizing and maintaining position in schools and herds...
  65. Ni R, Zheng D, Xiong S, Hill D, Sun T, Gardiner R, et al. Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes. 2016;65:255-68 pubmed publisher
    ..with an increase in mitochondrial ROS generation and oxidative damage and a reduction in ATP synthase-α (ATP5A1) protein and ATP synthase activity...
  66. Moser T, Kenan D, Ashley T, Roy J, Goodman M, Misra U, et al. Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci U S A. 2001;98:6656-61 pubmed
    ..We now have shown that antibodies directed against subunits of ATP synthase exhibit endothelial cell-inhibitory activities comparable to that of angiostatin, indicating that these antibodies function as angiostatin mimetics. ..
  67. Fischereit J, Schlünzen K. Evaluation of thermal indices for their applicability in obstacle-resolving meteorology models. Int J Biometeorol. 2018;62:1887-1900 pubmed publisher
    ..To assess such a design, obstacle-resolving models (ORM) combined with thermal indices may be used...
  68. Wang Q, Long Y, Hang A, Zan G, Shu X, Wang Y, et al. The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel ? agonist and ? partial agonist, in mice. Psychopharmacology (Berl). 2016;233:2411-8 pubmed publisher
    ..was to investigate the effects of (-)-3-N-ethylaminothiazolo [5,4-b]-N-cyclopropylmethylmorphinan hydrochloride (ATPM-ET), a novel ? agonist and ? partial agonist, in regulating emotional responses...
  69. Kimberlin A, Han G, Luttgeharm K, Chen M, Cahoon R, Stone J, et al. ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity. Plant Physiol. 2016;172:889-900 pubmed
    ..These findings indicate that ORM mediation of SPT activity differentially regulates functionally distinct ceramide synthase activities as part of a ..
  70. Franzoni G, Graham S, Giudici S, Bonelli P, Pilo G, Anfossi A, et al. Characterization of the interaction of African swine fever virus with monocytes and derived macrophage subsets. Vet Microbiol. 2017;198:88-98 pubmed publisher
    ..avirulent strain (BA71V) of ASFV with porcine monocytes, un-activated (moM?), classically (moM1) and alternatively (moM2) activated monocyte-derived macrophages was conducted in an attempt to better understand this relationship...
  71. Maher D, Khan S, Nordquist J, Ebeling M, Bauer N, Kopel L, et al. Ormeloxifene efficiently inhibits ovarian cancer growth. Cancer Lett. 2015;356:606-12 pubmed publisher
    ..Therefore, we examined whether ormeloxifene (ORM), a non-steroidal Selective Estrogen Receptor Modulator (SERM) currently used for contraception, is therapeutically ..
  72. Hagerman G, Noel N, Cao S, Duval M, Oel A, Allison W. Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish. PLoS ONE. 2016;11:e0166932 pubmed publisher
    ..We assessed the loss and recovery of vision in larvae via the optomotor behavioural response (OMR)...
  73. Pawlak P, Warzych E, Hryciuk M, Lechniak D. Transcript abundance, glutathione and apoptosis levels differ between porcine oocytes collected from prepubertal and cyclic gilts. Theriogenology. 2015;84:86-93 pubmed publisher
    ..present research was to analyze the transcript abundance of developmentally important genes (BMP15, GDF9, GSTA2, ATP5A1, EEF1A1, BAX, BCL2) followed by investigation of the glutathione and apoptosis level in oocytes of prepubertal and ..
  74. Reiser V, Alterman M, Shuster A, Kleinman S, Shlomi B, Yanko Arzi R, et al. V-stand--a versatile surgical platform for oromandibular reconstruction using a 3-dimensional virtual modeling system. J Oral Maxillofac Surg. 2015;73:1211-26 pubmed publisher
    The challenge of oromandibular reconstruction (OMR) after oncologic resections has been repeatedly addressed in the literature...
  75. D Avila Ã, Biolchi V, Capp E, Corleta H. Age, anti-müllerian hormone, antral follicles count to predict amenorrhea or oligomenorrhea after chemotherapy with cyclophosphamide. J Ovarian Res. 2015;8:82 pubmed publisher
    A cohort study was performed to identify ovarian reserve markers (ORM) that predicts amenorrhea or oligomenorrhea 6 months after cyclophosphamide CTX in women with breast cancer. 52 eumenorrheic patients with breast cancer were enrolled...
  76. Nagy L, Pollesello P, Haikala H, Végh Ã, Sorsa T, Levijoki J, et al. ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy. Eur J Pharmacol. 2016;775:120-9 pubmed publisher
    This study is the first pharmacological characterization of the novel chemical entity, ORM-3819 (L-6-{4-[N'-(4-Hydroxi-3-methoxy-2-nitro-benzylidene)-hydrazino]-phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one), focusing primarily on its ..
  77. Wang C, Du J, Du S, Liu Y, Li D, Zhu X, et al. Endogenous H2S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice. Mol Cell Endocrinol. 2018;474:65-73 pubmed publisher
    ..b>ATP5A1 was further confirmed as S-sulfhydrated using a modified biotin switch assay...
  78. Chen X, Xu W, Miao M, Zhu Z, Dai J, Chen Z, et al. Alteration of sperm protein profile induced by cigarette smoking. Acta Biochim Biophys Sin (Shanghai). 2015;47:504-15 pubmed publisher
    ..Furthermore, the 2DE and MS results of five proteins (Aldoa, ATP5a1, Gpx4, Cs, and Spatc1) were validated by western blot analysis and reverse transcriptase-polymerase chain reaction...
  79. Sharma A, Jaiswal S, Shukla M, Malik M, Lal J. Rapid quantitative analysis of ormeloxifene and its active metabolite, 7-desmethyl ormeloxifene, in rat plasma using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;997:7-15 pubmed publisher
    Ormeloxifene (ORM) is a non-steroidal, selective estrogen receptor modulator used as a once a week oral contraceptive and is intended for long-term clinical use by females...
  80. Diagboya P, Olu Owolabi B, Adebowale K. Distribution and interactions of pentachlorophenol in soils: The roles of soil iron oxides and organic matter. J Contam Hydrol. 2016;191:99-106 pubmed publisher
    ..batch sorption studies were carried out on whole soils and soils selectively treated to remove IOs (IOR) and OM (OMR). The effects of pH, time, and temperature were investigated...
  81. Scalise K, Shimizu T, Hibi M, Sawtell N. Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. J Neurophysiol. 2016;116:2067-2080 pubmed publisher
    ..and climbing fiber responses in larval zebrafish Purkinje cells in the context of the fictive optomotor response (OMR)-a paradigm in which fish adjust motor output to stabilize their virtual position relative to a visual stimulus...
  82. Penicka M, Vecera J, Mirica D, Kotrc M, Kockova R, Van Camp G. Prognostic Implications of Magnetic Resonance-Derived Quantification in Asymptomatic Patients With Organic Mitral Regurgitation: Comparison With Doppler Echocardiography-Derived Integrative Approach. Circulation. 2018;137:1349-1360 pubmed publisher
    ..resonance imaging (MRI) is an accurate method for the quantitative assessment of organic mitral regurgitation (OMR)...
  83. Uys M, Shahid M, Sallinen J, Dreyer W, Cockeran M, Harvey B. The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:108-16 pubmed publisher
    ..We investigated whether the α2C-AR antagonist, ORM-10921, could modulate sensorimotor gating and cognitive deficits, as well as alter striatal BDNF levels in the ..
  84. Caperna T, Shannon A, Stoll M, Kahl S, Blomberg L, Vallet J, et al. A sandwich ELISA for porcine alpha-1 acid glycoprotein (pAGP, ORM-1) and further demonstration of its use to evaluate growth potential in newborn pigs. Domest Anim Endocrinol. 2017;60:75-82 pubmed publisher
    A simple, reproducible sandwich, ELISA was developed to measure porcine alpha-1 acid glycoprotein (pAGP, ORM-1) in pig plasma...
  85. Kretschmer F, Tariq M, Chatila W, Wu B, Badea T. Comparison of optomotor and optokinetic reflexes in mice. J Neurophysiol. 2017;118:300-316 pubmed publisher
    ..These reflexes elicit compensatory head movements (optomotor response, OMR) in unrestrained animals or compensatory eye movements (optokinetic response, OKR) in head-fixed or unrestrained ..
  86. Mui A, Yang V, Aung M, Fu J, Adekunle A, Prall B, et al. Daily visual stimulation in the critical period enhances multiple aspects of vision through BDNF-mediated pathways in the mouse retina. PLoS ONE. 2018;13:e0192435 pubmed publisher
    ..This study aimed to determine whether visual stimulation in the form of daily optomotor response (OMR) testing during the mouse critical period (1) improves aspects of visual function, (2) involves retinal mechanisms ..
  87. Oyeniran C, Sturgill J, Hait N, Huang W, Avni D, Maceyka M, et al. Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol. 2015;136:1035-46.e6 pubmed publisher
    ..Genome-wide association studies have identified ORM (yeast)-like protein isoform 3 (ORMDL3) as a gene associated with susceptibility to asthma...
  88. Yacubian E, Wolf P. Orofacial reflex myocloni. Definition, relation to epilepsy syndromes, nosological and prognosis significance. A focused review. Seizure. 2015;30:1-5 pubmed publisher
    ..Among the complex triggers of seizures, this review considers orofacial reflex myocloni (ORM) from the aspects of history and delineation, clinical and electroencephalographic presentation, syndromatic ..
  89. Wang Y, Wu A, Lau J. The health belief model and number of peers with internet addiction as inter-related factors of Internet addiction among secondary school students in Hong Kong. BMC Public Health. 2016;16:272 pubmed publisher
    ..remained significant but the strength of association diminished ('quite a number': males: multivariate odds ratio (ORm)?= 2.07; females: ORm?= 2.44; 'a large number': males: ORm?= 2.39; females: ORm?= 3.56)...
  90. Wang Z, Zhao X, Zhang Z, Luo M, Shen Q, Dong Y, et al. Co-Occurring Psychosocial Problems and Multiple Sexual Partners among Men Who Have Sex with Men in Shanghai, China: A Syndemic Approach. J Sex Res. 2017;:1-10 pubmed publisher
    ..Sexual compulsivity (multivariate odds ratio [ORm] = 2.94, 95% CI = 1.76-4.91) and IS (ORm = 1.79, 95% CI = 1.14-2...
  91. Manda B, Mir H, Gangwar R, Meena A, Amin S, Shukla P, et al. Phosphorylation hotspot in the C-terminal domain of occludin regulates the dynamics of epithelial junctional complexes. J Cell Sci. 2018;131: pubmed publisher
    ..of phosphorylation sites, we distinguished a sequence in the C-terminal domain of occludin as a regulatory motif (ORM)...
  92. Boyer P, Cross R, Momsen W. A new concept for energy coupling in oxidative phosphorylation based on a molecular explanation of the oxygen exchange reactions. Proc Natl Acad Sci U S A. 1973;70:2837-9 pubmed
    ..This release could logically involve energy-requiring protein conformational change. ..