ATP2B4

Summary

Gene Symbol: ATP2B4
Description: ATPase plasma membrane Ca2+ transporting 4
Alias: ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x, plasma membrane calcium-transporting ATPase 4, ATPase, Ca++ transporting, plasma membrane 4, matrix-remodeling-associated protein 1, sarcolemmal calcium pump
Species: human
Products:     ATP2B4

Top Publications

  1. Howard A, Legon S, Walters J. Human and rat intestinal plasma membrane calcium pump isoforms. Am J Physiol. 1993;265:G917-25 pubmed
    ..a minor additional variant lacking the exon at splice site B was detected, which resembled that described for PMCA4. Of the variants described at site C, only the shortest transcript of PMCA1 was amplified; both previously ..
  2. Wan T, Zabe M, Dean W. Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets. Thromb Haemost. 2003;89:122-31 pubmed
    Plasma membrane Ca(2+) -ATPase isoform 4b (PMCA4b) is phosphorylated on a tyrosine residue during platelet activation resulting in inhibition of its ATPase activity...
  3. Strehler E, James P, Fischer R, Heim R, Vorherr T, Filoteo A, et al. Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. J Biol Chem. 1990;265:2835-42 pubmed
  4. Brandt P, Zurini M, Neve R, Rhoads R, Vanaman T. A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. Proc Natl Acad Sci U S A. 1988;85:2914-8 pubmed
    ..Portions of the isolated cDNA were homologous to the 3' noncoding region of the sarcoplasmic reticulum Ca2+-ATPase cDNA, indicating a possible mechanism for the evolution of these distinct membrane Ca2+ pumps. ..
  5. Stauffer T, Hilfiker H, Carafoli E, Strehler E. Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. J Biol Chem. 1993;268:25993-6003 pubmed
  6. Adamo H, Filoteo A, Enyedi A, Penniston J. Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation. J Biol Chem. 1995;270:30111-4 pubmed
    ..However, the rate of decomposition of this intermediate was much slower than that of the wild type, indicating that the inhibition of this mutant resulted from an inhibition of the E approximately P-->E step in the enzyme cycle. ..
  7. Kim E, DeMarco S, Marfatia S, Chishti A, Sheng M, Strehler E. Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains. J Biol Chem. 1998;273:1591-5 pubmed
    ..Alternative splicing may dictate their specific interaction with PDZ domain-containing proteins, potentially influencing their localization and incorporation into functional multiprotein complexes at the plasma membrane. ..
  8. Strehler E, Zacharias D. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev. 2001;81:21-50 pubmed
  9. DeMarco S, Strehler E. Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. J Biol Chem. 2001;276:21594-600 pubmed
    ..The related MAGUKs SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bound to the COOH-terminal tail of PMCA4b, whereas only the first three bound to the tail of PMCA2b...

More Information

Publications135 found, 100 shown here

  1. Schuh K, Uldrijan S, Telkamp M, Rothlein N, Neyses L. The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J Cell Biol. 2001;155:201-5 pubmed
    ..Elucidation of PMCA as an interaction partner and major regulator of NOS-I provides evidence for a new dimension of integration between calcium and NO signaling pathways. ..
  2. Goellner G, DeMarco S, Strehler E. Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants. Ann N Y Acad Sci. 2003;986:461-71 pubmed
    ..When added to microsomal membranes expressing PMCA4b, PISP was unable to stimulate the PMCA-dependent ATPase activity...
  3. Buch M, Pickard A, Rodriguez A, Gillies S, Maass A, Emerson M, et al. The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit. J Biol Chem. 2005;280:29479-87 pubmed
    ..There is increasing evidence placing the sarcolemmal calcium pump, or plasma membrane calcium/calmodulin ATPase pump (PMCA), as a potential modulator of signal ..
  4. Ryan Z, Craig T, Filoteo A, Westendorf J, Cartwright E, Neyses L, et al. Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3. Biochem Biophys Res Commun. 2015;467:152-6 pubmed publisher
    ..Deletion of the Pmca1 in the intestine is associated with reduced growth and bone mineralization, and a failure to up-regulate calcium absorption in response to 1α,25(OH)2D3. ..
  5. Baggott R, Alfranca A, López Maderuelo D, Mohamed T, Escolano A, Oller J, et al. Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin. Arterioscler Thromb Vasc Biol. 2014;34:2310-20 pubmed publisher
    ..Using in vitro and in vivo assays, we here demonstrate that the interaction between PMCA4 and calcineurin in VEGF-stimulated endothelial cells leads to downregulation of the calcineurin/NFAT pathway and ..
  6. Duan W, Zhou J, Li W, Zhou T, Chen Q, Yang F, et al. Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase. Protein Cell. 2013;4:286-98 pubmed publisher
    ..the occurrence of Ca(2+)-induced protein-protein interactions between plasma membrane calcium ATPase 4b (PMCA4b) and nNOS in living cells...
  7. Afroze T, Yang G, Khoshbin A, Tanwir M, Tabish T, Momen A, et al. Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cells. J Biol Chem. 2014;289:7221-31 pubmed publisher
    ..injury (to ?1:3) by modulation of alternative splicing, as confirmed by novel antibodies against PMCA4a/e and PMCA4b. Laser capture microdissection localized this shift to the media and adventitia...
  8. Olson S, Wang M, Carafoli E, Strehler E, McBride O. Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. Genomics. 1991;9:629-41 pubmed
    ..isoforms have been used as probes to localize chromosomally the human PMCA1 (ATP2B1) gene to 12q21-q23 and PMCA4 (ATP2B2) to 1q25-q32...
  9. Pászty K, Verma A, Padányi R, Filoteo A, Penniston J, Enyedi A. Plasma membrane Ca2+ATPase isoform 4b is cleaved and activated by caspase-3 during the early phase of apoptosis. J Biol Chem. 2002;277:6822-9 pubmed
    ..that caspase-3 or a caspase-3-like protease is responsible for the formation of the constitutively active 120-kDa PMCA4b fragment: 1) Pretreatment of the cells with the caspase-3 inhibitor Z-DEVD-FMK (benzyloxycarbonyl-Asp(OMe)-Glu(OMe)..
  10. Kim H, Prasad V, Hyung S, Lee Z, Lee S, Bhargava A, et al. Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012;199:1145-58 pubmed publisher
    ..b>PMCA4 also had an anti-osteoclastogenic effect by reducing NO, which facilitates preosteoclast fusion...
  11. Mohamed T, Abou Leisa R, Stafford N, Maqsood A, Zi M, Prehar S, et al. The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy. Nat Commun. 2016;7:11074 pubmed publisher
    ..response is regulated by cardiac fibroblasts via a paracrine mechanism involving plasma membrane calcium ATPase 4 (PMCA4)...
  12. Supper V, Schiller H, Paster W, Forster F, Boulègue C, Mitulovic G, et al. Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling. J Immunol. 2016;196:1387-99 pubmed publisher
    ..of CD147 interaction partners and identified the calcium exporter plasma membrane calcium ATPase isoform 4 (PMCA4) as the interaction partner of the immunosuppressive moieties of CD147...
  13. Mohamed T, Oceandy D, Prehar S, Alatwi N, Hegab Z, Baudoin F, et al. Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J Biol Chem. 2009;284:12091-8 pubmed publisher
    ..We have demonstrated previously that isoform 4b of the sarcolemmal calcium pump (PMCA4b) binds to nNOS in the heart and that this complex regulates beta-adrenergic signal transmission ..
  14. Al Dossary A, Bathala P, Caplan J, Martin DeLeon P. Oviductosome-Sperm Membrane Interaction in Cargo Delivery: DETECTION OF FUSION AND UNDERLYING MOLECULAR PLAYERS USING THREE-DIMENSIONAL SUPER-RESOLUTION STRUCTURED ILLUMINATION MICROSCOPY (SR-SIM). J Biol Chem. 2015;290:17710-23 pubmed publisher
    ..Oviductosomes ((OVS), exosomes/microvesicles), which deliver the Ca(2+) efflux pump, plasma membrane Ca(2+)ATPase 4 (PMCA4), to sperm are likely to play an important role in sperm fertilizing ability (Al-Dossary, A. A., Strehler, E. E...
  15. Ndila C, Uyoga S, Macharia A, Nyutu G, Peshu N, Ojal J, et al. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol. 2018;5:e333-e345 pubmed publisher
    ..malaria overall and polymorphisms in 15 genes or locations, of which most were related to red blood cells: ABO, ATP2B4, ARL14, CD40LG, FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, ..
  16. Canet Pons J, Schubert R, Duecker R, Schrewe R, Wölke S, Kieslich M, et al. Ataxia telangiectasia alters the ApoB and reelin pathway. Neurogenetics. 2018;19:237-255 pubmed publisher
    ..for Vglut2/Sema7a as climbing fiber markers, glutamate receptors like Grin2b, and calcium homeostasis factors (Atp2b2, Calb1, Itpr1), while factors involved in DNA damage, oxidative stress, neuroinflammation, and cell adhesion were ..
  17. Varga K, Hollósi A, Pászty K, Hegedüs L, Szakacs G, Timar J, et al. Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells. BMC Cancer. 2018;18:1029 pubmed publisher
    ..Three distinct datasets displayed significantly lower ATP2B4 mRNA expression in invasive breast cancer tissue samples compared to normal breast tissue, whereas the expression ..
  18. Andrews R, Galileo D, Martin DeLeon P. Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase. Mol Hum Reprod. 2015;21:832-43 pubmed publisher
    Deletion of the gene encoding the widely conserved plasma membrane calcium ATPase 4 (PMCA4), a major Ca(2+) efflux pump, leads to loss of sperm motility and male infertility in mice...
  19. Berrocal M, Corbacho I, Sepulveda M, Gutierrez Merino C, Mata A. Phospholipids and calmodulin modulate the inhibition of PMCA activity by tau. Biochim Biophys Acta Mol Cell Res. 2017;1864:1028-1035 pubmed publisher
    ..Functional studies were also performed with native and truncated versions of human cerebral PMCA4b, an isoform that has been showed to be functionally regulated by amyloid peptides, whose aggregates constitutes ..
  20. Minich R, Li J, Tempel B. Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system. BMC Mol Biol. 2017;18:14 pubmed publisher
    ..There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes the protein pump with the fastest activation, ATP2B2...
  21. James A, Patel W, Butt Z, Adiamah M, Dakhel R, Latif A, et al. The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP. J Biol Chem. 2015;290:24760-71 pubmed publisher
  22. Lisek M, Ferenc B, Studzian M, Pulaski L, Guo F, Zylinska L, et al. Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. Front Cell Neurosci. 2017;11:181 pubmed publisher
    ..Expression of the PDZ domain-containing scaffold protein PSD95 was induced and its association with PMCA4 was higher in most brain compartments upon ketamine treatment...
  23. Stauffer T, Hilfiker H, Carafoli E, Strehler E. Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. J Biol Chem. 1994;269:32022 pubmed
  24. Tang D, Dean W, Borchman D, Paterson C. The influence of membrane lipid structure on plasma membrane Ca2+ -ATPase activity. Cell Calcium. 2006;39:209-16 pubmed
    ..Changes in lipid composition such as those observed with age or disease could potentially influence PMCA function. ..
  25. Basit S, Albalawi A, Alharby E, Khoshhal K. Exome sequencing identified rare variants in genes HSPG2 and ATP2B4 in a family segregating developmental dysplasia of the hip. BMC Med Genet. 2017;18:34 pubmed publisher
    ..An analysis of the WES data identified rare heterozygous variants in HSPG2 and ATP2B4 genes in the affected individuals...
  26. Kurusamy S, López Maderuelo D, Little R, Cadagan D, Savage A, Ihugba J, et al. Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion. J Mol Cell Cardiol. 2017;109:38-47 pubmed publisher
    ..Plasma membrane calcium ATPase 4 (PMCA4) negatively regulates VEGF-activated angiogenesis via inhibition of the calcineurin/NFAT signalling pathway...
  27. Lestari S, Miati D, Seoharso P, Sugiyanto R, Pujianto D. Sperm Na+, K+-ATPase α4 and plasma membrane Ca2+-ATPase (PMCA) 4 regulation in asthenozoospermia. Syst Biol Reprod Med. 2017;63:294-302 pubmed publisher
    ..and Ca2+-ATPase and the expression of Na+, K+-ATPase α4 and PMCA4 isoforms in human sperm of asthenozoospermic infertile men...
  28. Bortolozzi M, Mammano F. PMCA2 pump mutations and hereditary deafness. Neurosci Lett. 2018;663:18-24 pubmed publisher
    ..These results highlight a critical role played by the PMCA2w/a pump in the control of hair cell function and survival, and provide mechanistic insight into the etiology of deafness and vestibular disorders. ..
  29. Peng K, Bacon J, Zheng M, Guo Y, Wang M. Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach. Drug Metab Dispos. 2015;43:1045-55 pubmed publisher
    ..proteomic approach, we determined hepatic protein concentrations of OATP1B1, OATP1B3, OATP2B1, P-gp, and PMCA4 (a housekeeping protein) in a panel of human livers (n = 141) and compared protein expression across Caucasian, ..
  30. Pachera N, Papin J, Zummo F, Rahier J, Mast J, Meyerovich K, et al. Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability. Diabetologia. 2015;58:2843-50 pubmed publisher
    ..release and immunohistochemistry) were used to assess beta cell function and proliferation in Pmca2 (also known as Atp2b2) heterozygous mice and control littermates ex vivo...
  31. Olli K, Li K, Galileo D, Martin DeLeon P. Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity. J Cell Physiol. 2018;233:11-22 pubmed publisher
    ..asthenospermia) and resulting infertility arise from deletion of the Plasma Membrane Ca2+ -ATPase 4 (Pmca4) gene which encodes the highly conserved Ca2+ efflux pump, PMCA4...
  32. Ilboudo Y, Bartolucci P, Rivera A, Sedzro J, Beaudoin M, Trudel M, et al. Genome-wide association study of erythrocyte density in sickle cell disease patients. Blood Cells Mol Dis. 2017;65:60-65 pubmed publisher
    ..This intronic variant controls the expression of ATP2B4, the main calcium pump in erythrocytes...
  33. Hegedüs L, Padányi R, Molnar J, Pászty K, Varga K, Kenessey I, et al. Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca2+ Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK. Front Oncol. 2017;7:95 pubmed publisher
    ..Previously, we identified the plasma membrane Ca2+ ATPase 4b (PMCA4b) as a metastasis suppressor in BRAF-mutant melanomas and found that mutant BRAF inhibition increased the ..
  34. Guo B, Tang Z, Wu C, Xu K, Qi P. Transcriptomic analysis reveal an efficient osmoregulatory system in Siberian sturgeon Acipenser baeri in response to salinity stress. Sci Rep. 2018;8:14353 pubmed publisher
    ..In all DEGs, some of the typical genes involved in osmoregulation, including calcium-transporting ATPase 4 (ATP2B4), Na+/K+-ATPase alpha subunit (?-NKA), potassium-transporting ATPase alpha chain 1 (ATP4A) ..
  35. Armesilla A, Williams J, Buch M, Pickard A, Emerson M, Cartwright E, et al. Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). J Biol Chem. 2004;279:31318-28 pubmed
    ..A two-hybrid screen of a human fetal heart cDNA library, using the region 652-840 of human PMCA4b (located in the catalytic, second intracellular loop) as bait, revealed a novel interaction between PMCA4b and the ..
  36. Hwang H, Park C, Goodarzi H, Fak J, Mele A, Moore M, et al. PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage. Cell Rep. 2016;15:423-35 pubmed publisher
    ..harboring functional miRNA binding sites and reveals developmentally regulated APA shifts, including one in Atp2b2 that is evolutionarily conserved in humans and results in the gain of a functional binding site of miR-137...
  37. White K, Gesek F, Nesbitt T, Drezner M, Friedman P. Molecular dissection of Ca2+ efflux in immortalized proximal tubule cells. J Gen Physiol. 1997;109:217-28 pubmed
    ..S1, S2, and S3 cells exhibited only PMCA1 and PMCA4 products. PCR product identity was confirmed by sequence analysis...
  38. Xu Y, Qi X, Hu M, Lin R, Hou Y, Wang Z, et al. Transcriptome Analysis of Adipose Tissue Indicates That the cAMP Signaling Pathway Affects the Feed Efficiency of Pigs. Genes (Basel). 2018;9: pubmed publisher
    ..Furthermore, ATP2B2, ATP1A4, and VIPR2, which participate in the cAMP signaling pathway, were down-regulated in the ..
  39. Oksenberg N, Haliburton G, Eckalbar W, Oren I, Nishizaki S, Murphy K, et al. Genome-wide distribution of Auts2 binding localizes with active neurodevelopmental genes. Transl Psychiatry. 2014;4:e431 pubmed publisher
    ..In addition, we characterized two functional brain enhancers marked by Auts2 near NRXN1 and ATP2B2, both ASD-implicated genes...
  40. Tran Q, Vermeer M, Burgard M, Hassan A, Giles J. Hetero-oligomeric Complex between the G Protein-coupled Estrogen Receptor 1 and the Plasma Membrane Ca2+-ATPase 4b. J Biol Chem. 2015;290:13293-307 pubmed publisher
    ..Heterologously expressed GPER/GPR30 in HEK 293 cells co-localizes with PMCA4b, the main endothelial PMCA isoform...
  41. Johnston H, Carter M, Larrayoz M, Clarke J, Garbis S, Oscier D, et al. Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation. Mol Cell Proteomics. 2018;17:776-791 pubmed publisher
    ..g. CKAP4, PIGR, TMCC3 and CD75) and three of these (LAX1, CLEC17A and ATP2B4) were implicated in B-cell receptor signaling, which plays an important role in CLL pathogenesis...
  42. Travaglini L, Aiello C, Stregapede F, D Amico A, Alesi V, Ciolfi A, et al. The impact of next-generation sequencing on the diagnosis of pediatric-onset hereditary spastic paraplegias: new genotype-phenotype correlations for rare HSP-related genes. Neurogenetics. 2018;19:111-121 pubmed publisher
    ..respectively, complex and pure HSP, a large number of pathogenic variants were disclosed in POLR3A, FA2H, DDHD2, ATP2B4, ENTPD1, ERLIN2, CAPN1, ALS2, ADAR1, RNASEH2B, TUBB4A, ATL1, and KIF1A...
  43. Dally S, Chaabane C, Corvazier E, Bredoux R, Bobe R, Ftouhi B, et al. Increased expression of plasma membrane Ca(2+)ATPase 4b in platelets from hypertensives: a new sign of abnormal thrombopoiesis?. Platelets. 2007;18:543-9 pubmed
    ..Very recently, we found that platelets from diabetic patients also exhibited increased PMCA4b expression. In the present study we looked for further similarities between diabetic and hypertensive patients...
  44. Prasad V, Lorenz J, Lasko V, Nieman M, Jiang M, Gao X, et al. Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2014;77:53-63 pubmed publisher
    ..We investigated the role of the plasma membrane Ca(2+)-ATPase PMCA4 in the HCM phenotype using a transgenic model that expresses mutant (Glu180Gly) α-tropomyosin (Tm180) in heart...
  45. Wan T, Dean W. Decreased PMCA4b expression has no effect on calcium homeostasis in Meg-01 cells. Platelets. 2003;14:295-303 pubmed
    ..We examined the effects of stable production of antisense RNAs targeted to the PMCA subtype 4b (PMCA4b) on cultured human megakaryoblastic (Meg-01) cells...
  46. Wang L, Velazquez H, Chang J, Safirstein R, Desir G. Identification of a receptor for extracellular renalase. PLoS ONE. 2015;10:e0122932 pubmed publisher
    ..RP-220 in the human proximal tubular cell line HK-2 and protein identification by mass spectrometry, we identified PMCA4b as a renalase binding protein...
  47. Boczek T, Ferenc B, Lisek M, Zylinska L. Regulation of GAP43/calmodulin complex formation via calcineurin-dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition. Mol Cell Biochem. 2015;407:251-62 pubmed publisher
  48. Gelabert P, Olalde I, de Dios T, Civit S, Lalueza Fox C. Malaria was a weak selective force in ancient Europeans. Sci Rep. 2017;7:1377 pubmed publisher
    ..We detected statistically significant differences between ancient and modern populations for the ATP2B4, FCGR2B and ABO genes and we found evidence of selection at IL-10 and ATP2B4 genes...
  49. dela Peña I, Bang M, Lee J, de la Peña J, Kim B, Han D, et al. Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior. Behav Brain Res. 2015;291:268-276 pubmed publisher
    ..Wistar rats are those involved in transcription (e.g. Creg1, Thrsp, Zeb2), synaptic transmission (e.g. Atp2b2, Syt12, Chrna5), neurological system process (e.g. Atg7, Cacnb4, Grin3a), and immune response (e.g...
  50. Alexander R, Beggs M, Zamani R, Marcussen N, Frische S, Dimke H. Ultrastructural and immunohistochemical localization of plasma membrane Ca2+-ATPase 4 in Ca2+-transporting epithelia. Am J Physiol Renal Physiol. 2015;309:F604-16 pubmed publisher
    ..The Pmca4 isoform is enriched in distal nephron isolates and decreased in mice lacking the epithelial transient receptor ..
  51. Robertson S, Wen X, Yin K, Chen J, Smith C, Paine M. Multiple Calcium Export Exchangers and Pumps Are a Prominent Feature of Enamel Organ Cells. Front Physiol. 2017;8:336 pubmed publisher
    ..pathways that have been described and adds novel insights to the spatiotemporal expression patterns of PMCA1, PMCA4, and NCKX3 during amelogenesis...
  52. Bredoux R, Corvazier E, Dally S, Chaabane C, Bobe R, Raies A, et al. Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis. Platelets. 2006;17:421-33 pubmed
    ..Here, we first investigated the expression of PMCA4b, SERCA3a and SERCA2b isoforms in platelets of 17 patients with AIS...
  53. Geyik E, Igci Y, Pala E, Suner A, Borazan E, Bozgeyik I, et al. Investigation of the association between ATP2B4 and ATP5B genes with colorectal cancer. Gene. 2014;540:178-82 pubmed publisher
    ..Therefore, development of alternative diagnostic methods which can be used in the early diagnosis is crucial. ATP2B4 gene encodes one of the four isoforms of p-type ATPase PMCA enzyme and bears critical importance in maintaining ..
  54. Gao Y, Tao Y, Chu H, Chen J, Chen Q, Zhou L, et al. [Age-related expression of plasma membrane Ca(2+) -ATPase isoform 2 in the cochleas of C57BL/6J mice]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;50:934-8 pubmed
    ..The results of Rt-PCR demonstrated the expression of mRNA of gene (Atp2b2) at 14 weeks age was significantly less than 4 week-old mice cochlears (P<0.05)...
  55. van Loon E, Little R, Prehar S, Bindels R, Cartwright E, Hoenderop J. Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?. PLoS ONE. 2016;11:e0153483 pubmed publisher
    ..However, in recent studies TRPV5-expressing tubules were shown to highly express PMCA4. Therefore, PMCA4 may have a predominant role in renal Ca2+ handling...
  56. Khariv V, Elkabes S. Contribution of Plasma Membrane Calcium ATPases to neuronal maladaptive responses: Focus on spinal nociceptive mechanisms and neurodegeneration. Neurosci Lett. 2018;663:60-65 pubmed publisher
    ..Other PMCA isoforms and in particular, PMCA4, also contribute to the excitability of neurons in the dorsal root ganglia (DRG), which contain the first-order ..
  57. Calcagno A, Chewning K, Wu C, Ambudkar S. Plasma membrane calcium ATPase (PMCA4): a housekeeper for RT-PCR relative quantification of polytopic membrane proteins. BMC Mol Biol. 2006;7:29 pubmed
  58. Little R, Cartwright E, Neyses L, Austin C. Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension. Pharmacol Ther. 2016;159:23-34 pubmed publisher
    ..Altered expression or inhibition of PMCA4 has also been shown to modulate these parameters...
  59. Krapivinsky G, Krapivinsky L, Stotz S, Manasian Y, Clapham D. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A. 2011;108:19234-9 pubmed publisher
    ..Store depletion promotes STIM1-POST complex binding to smooth ER and plasma membrane Ca(2+) ATPases (SERCAs and PMCAs, respectively), Na/K-ATPase, as well as to the nuclear transporters, importins-? and exportins. ..
  60. Al Dossary A, Martin DeLeon P. Role of exosomes in the reproductive tract Oviductosomes mediate interactions of oviductal secretion with gametes/early embryo. Front Biosci (Landmark Ed). 2016;21:1278-85 pubmed
    ..fertility-modulating proteins such as oviduct-specific glycoprotein (OVGP) and Plasma Membrane Ca(2+) ATPase 4 (PMCA4)...
  61. Bredeston L, Adamo H. Loss of autoinhibition of the plasma membrane Ca(2+) pump by substitution of aspartic 170 by asparagin. A ctivation of plasma membrane calcium ATPase 4 without disruption of the interaction between the catalytic core and the C-terminal regulatory dom. J Biol Chem. 2004;279:41619-25 pubmed
  62. Choi J, Wang C, Thomas M, Pitt G. ?1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current. PLoS ONE. 2016;11:e0152355 pubmed publisher
    ..Electrophysiological studies were performed in HEK293T cells co-expressing human NaV1.5/nNOS/PMCA4b with either wild type (WT) or SNTA1 variants (A390V-previously reported in congenital LQTS; and E409Q); and in ..
  63. Krebs J. The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plasma Membrane Microdomains. Adv Exp Med Biol. 2017;981:3-21 pubmed publisher
    ..The importance of PMCA for regulating Ca2+ signaling in microdomains under different conditions is also discussed. ..
  64. Lee W, Roberts Thomson S, Monteith G. Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochem Biophys Res Commun. 2005;337:779-83 pubmed
    ..PMCA2 in particular is upregulated extensively during lactation. Expression of other isoforms such as PMCA4 may influence mammary gland epithelial cell proliferation and aberrant regulation of PMCA isoform expression may ..
  65. Peters A, Milevskiy M, Lee W, Curry M, Smart C, Saunus J, et al. The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Sci Rep. 2016;6:25505 pubmed publisher
    ..of PMCA2 reduced MDA-MB-231 breast cancer cell proliferation, whereas silencing of the related isoforms PMCA1 and PMCA4 had no effect. PMCA2 silencing also sensitized MDA-MB-231 cells to the cytotoxic agent doxorubicin...
  66. Brandt P, Neve R, Kammesheidt A, Rhoads R, Vanaman T. Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. J Biol Chem. 1992;267:4376-85 pubmed
    ..The known alternately spliced forms of these Ca(2+)-ATPase mRNAs and a new spliced variant of PMCA4 (PMCA4b), presented here, represent at least nine different mRNAs encoding the Ca(2+)-ATPases...
  67. Pászty K, Caride A, Bajzer Å, Offord C, Padányi R, Hegedűs L, et al. Plasma membrane Ca²⁺-ATPases can shape the pattern of Ca²⁺ transients induced by store-operated Ca²⁺ entry. Sci Signal. 2015;8:ra19 pubmed publisher
    ..We studied the effects of three PMCA isoforms (PMCA4a, PMCA4b, and PMCA2b) on Ca(2+) transients elicited by conditions that trigger store-operated Ca(2+) entry (SOCE) and that ..
  68. Rajman M, Metge F, Fiore R, Khudayberdiev S, Aksoy Aksel A, Bicker S, et al. A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses. EMBO J. 2017;36:1770-1787 pubmed publisher
    ..severity in vivo Using transcriptome, proteome, and bioinformatic analysis, we identified the calcium pump Atp2b4 and doublecortin (Dcx) as miR-129-5p targets...
  69. Whitfield M, Guiton R, Rispal J, Acar N, Kocer A, Drevet J, et al. Dyslipidemia alters sperm maturation and capacitation in LXR-null mice. Reproduction. 2017;154:827-842 pubmed publisher
    ..001 vs wt). The accumulation of the major sperm calcium efflux pump (PMCA4) was decreased in Lxrα;β-/- males fed the HCD (P<..
  70. Sadi A, Afroze T, Siraj M, Momen A, White Dzuro C, Zarrin Khat D, et al. Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury. Clin Sci (Lond). 2018;132:641-654 pubmed publisher
    ..Cardiac-specific overexpression of human PMCA4b in mice inhibited nNOS activity and reduced cardiac hypertrophy by inhibiting calcineurin...
  71. Veklich T, Mazur I, Kosterin S. [Mg2+, ATP-dependent plasma membrane calcium pump of smooth muscle cells. I. Structural organization and properties]. Ukr Biochem J. 2015;87:5-20 pubmed
    ..In this article we generalized literatute and own data about properties of smooth muscle cell plasma membrane Ca(2+)-pump. Stuctural oganization, kinetical properties and molecular biology are considered. ..
  72. Wu X, Chang B, Blair N, Sargent M, York A, Robbins J, et al. Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest. 2009;119:976-85 pubmed publisher
    ..We generated cardiac-specific inducible PMCA4b transgenic mice that displayed normal global Ca2+ transient and cellular contraction levels and reduced cardiac ..
  73. Corbacho I, García Prieto F, Hinojosa A, Berrocal M, Mata A. An improved method for expression and purification of functional human Ca(2+) transporter PMCA4b in Saccharomyces cerevisiae. Protein Expr Purif. 2016;120:51-8 pubmed publisher
    ..method provides a pure single isoform instead of a mixture of isoforms, essential for fine-tuning the activity of PMCA4b. Another relevant feature is that the method described in this work has a superior yield of protein than ..
  74. Boczek T, Lisek M, Ferenc B, Zylinska L. Cross talk among PMCA, calcineurin and NFAT transcription factors in control of calmodulin gene expression in differentiating PC12 cells. Biochim Biophys Acta Gene Regul Mech. 2017;1860:502-515 pubmed publisher
    ..Our results indicate that decrease in CaM level in response to PMCAs downregulation can be driven by CaN/NFAT pathway. ..
  75. Talarico E. Plasma membrane calcium-ATPase isoform four distribution changes during corneal epithelial wound healing. Mol Vis. 2010;16:2259-72 pubmed
    ..of PCR DNAs documented the presence of PMCA4 transcripts in rbCE and showed that the splice variant at site A was PMCA4x. Immunoblot analysis for PMCA4 detected an intense band at approximately 160 kDa and a faint band at approximately ..
  76. Oceandy D, Mohamed T, Cartwright E, Neyses L. Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4). Biochim Biophys Acta. 2011;1813:974-8 pubmed publisher
    ..we will review the recently emerging role of the plasma membrane calcium/calmodulin dependent ATPase isoform 4 (PMCA4) in regulating calcium signalling...
  77. Masvidal L, Alvarez A, Ruano L, De Gracia J, Larriba S, Casals T. GUSB and ATP2B4 are suitable reference genes for CFTR gene expression data normalization in nasal epithelium cells. J Cyst Fibros. 2012;11:398-404 pubmed publisher
    ..B2M, GUSB, HPRT1 and ATP2B4 expression was evaluated in nasal epithelium samples (CFTR-wt controls, n=21; CFTR-splicing group, n=18) by RT-..
  78. Williamson P. Substrate trajectory through phospholipid-transporting P4-ATPases. Biochem Soc Trans. 2014;42:1367-71 pubmed publisher
    ..There are currently three different models for this trajectory, all with support by mutation/activity measurements and analogies with known atomic structures. ..
  79. Ribiczey P, Papp B, Homolya L, Enyedi Ã, Kovács T. Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells. Biochem Biophys Res Commun. 2015;464:189-94 pubmed publisher
    We have previously presented co-expression of the plasma membrane calcium ATPase isoforms 4b (PMCA4b) and 1b (PMCA1b) in colon carcinoma cells, and selective upregulation of PMCA4b during differentiation initiated by short chain fatty ..
  80. Møller J, Juul B, le Maire M. Structural organization, ion transport, and energy transduction of P-type ATPases. Biochim Biophys Acta. 1996;1286:1-51 pubmed
  81. Zacharias D, DeMarco S, Strehler E. mRNA expression of the four isoforms of the human plasma membrane Ca(2+)-ATPase in the human hippocampus. Brain Res Mol Brain Res. 1997;45:173-6 pubmed
    ..Differential expression of PMCA isoforms may reflect cellular differences in Ca(2+)-handling properties and provide a partial explanation for the differential susceptibility of hippocampal neurons to Ca(2+)-mediated cell death. ..
  82. Schuh K, Uldrijan S, Gambaryan S, Roethlein N, Neyses L. Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. J Biol Chem. 2003;278:9778-83 pubmed
    ..Additionally, it has been demonstrated that PMCA4b interacts with neuronal nitric-oxide synthase and that isoform 2b interacts with Na(+)/H(+) exchanger regulatory ..
  83. Moreau R, Daoud G, Masse A, Simoneau L, Lafond J. Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta. Mol Reprod Dev. 2003;65:283-8 pubmed
  84. Strehler E, Treiman M. Calcium pumps of plasma membrane and cell interior. Curr Mol Med. 2004;4:323-35 pubmed
  85. Holton M, Yang D, Wang W, Mohamed T, Neyses L, Armesilla A. The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells. FEBS Lett. 2007;581:4115-9 pubmed
    ..The domain of PMCA2 involved in the interaction is equivalent to that reported for PMCA4b. PMCA2-calcineurin interaction results in inhibition of the calcineurin/nuclear factor of activated T-cells ..
  86. Chaabane C, Dally S, Corvazier E, Bredoux R, Bobe R, Ftouhi B, et al. Platelet PMCA- and SERCA-type Ca2+ -ATPase expression in diabetes: a novel signature of abnormal megakaryocytopoiesis. J Thromb Haemost. 2007;5:2127-35 pubmed
    ..In addition, we recently found that the expression of PMCA4b and SERCA3 isoforms may serve as new markers of abnormal megakaryocytopoiesis [Nurden P et al...
  87. Ueda K, Valdivia C, Medeiros Domingo A, Tester D, Vatta M, Farrugia G, et al. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc Natl Acad Sci U S A. 2008;105:9355-60 pubmed publisher
    ..SNTA1 links neuronal nitric oxide synthase (nNOS) to the nNOS inhibitor plasma membrane Ca-ATPase subtype 4b (PMCA4b); SNTA1 also is known to associate with the cardiac sodium channel SCN5A...
  88. Padányi R, Pászty K, Strehler E, Enyedi A. PSD-95 mediates membrane clustering of the human plasma membrane Ca2+ pump isoform 4b. Biochim Biophys Acta. 2009;1793:1023-32 pubmed publisher
    ..with the postsynaptic density-95 (PSD-95) scaffolding protein increased the plasma membrane expression of PMCA4b and redistributed the pump into clusters...
  89. Juranic N, Atanasova E, Filoteo A, Macura S, Prendergast F, Penniston J, et al. Calmodulin wraps around its binding domain in the plasma membrane Ca2+ pump anchored by a novel 18-1 motif. J Biol Chem. 2010;285:4015-24 pubmed publisher
    ..C20) and the final bound complex by (holoCaM.C28). This affirms the existing multi-step kinetic model of PMCA4b activation by CaM...
  90. Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, et al. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature. 2012;489:443-6 pubmed publisher
    ..One of the loci was identified on chromosome 1q32 within the ATP2B4 gene, which encodes the main calcium pump of erythrocytes, the host cells of the pathogenic stage of malaria ..
  91. Ho P, Pang S, Li M, Tse Z, Kung M, Sham P, et al. PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion. Brain Behav. 2015;5:e00321 pubmed publisher
    ..803G>A, p.R268Q) in the plasma membrane calcium ATPase (PMCA4, or ATP2B4) gene in a Chinese family with autosomal dominant FSP...
  92. Dewey F, Grove M, Priest J, Waggott D, Batra P, Miller C, et al. Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLoS Genet. 2015;11:e1005496 pubmed publisher
    ..We also nominate a new candidate gene in congenital arrhythmia, ATP2B4, and provide experimental evidence of a regulatory role for variants discovered using this framework.