Gene Symbol: ATP1B3
Description: ATPase Na+/K+ transporting subunit beta 3
Alias: ATPB-3, CD298, sodium/potassium-transporting ATPase subunit beta-3, ATPase, Na+/K+ transporting, beta 3 polypeptide, Na, K-ATPase beta-3 polypeptide, sodium pump subunit beta-3, sodium-potassium ATPase subunit beta 3 (non-catalytic), sodium/potassium-dependent ATPase subunit beta-3, sodium/potassium-transporting ATPase beta-3 chain
Species: human
Products:     ATP1B3

Top Publications

  1. Yoshimura S, Iwasaka S, Schwarz W, Takeyasu K. Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells. J Cell Sci. 2008;121:2159-68 pubmed publisher
    ..All these results indicate that the alpha- and beta-subunits of Na(+)/K(+)-ATPase are assembled in the endoplasmic reticulum, but are disassembled in the plasma membrane and undergo different degradation processes. ..
  2. Zhang S, Liu D, Wang L, Li Y, Wang Y, Zhang H, et al. A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem. 2019;294:6375-6386 pubmed publisher identify CASPR1-interacting proteins and identified the β3 subunit of Na+/K+-ATPase (ATP1B3) as a CASPR1-binding protein...
  3. Hartmann F, Simonds E, Bendall S. A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. Sci Rep. 2018;8:10770 pubmed publisher
    ..both the MHC class I complex (beta-2-microglobulin) and a broadly expressed sodium-potassium ATPase-subunit (CD298) with platinum-conjugated antibodies, human immune cells, stem cells as well as tumor cells could be multiplexed ..
  4. Zacherl S, La Venuta G, Muller H, Wegehingel S, Dimou E, Sehr P, et al. A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2. J Biol Chem. 2015;290:3654-65 pubmed publisher
    ..As opposed to ATP1A1, down-regulation of the β1- and β3-chains (ATP1B1 and ATP1B3) of the Na/K-ATPase did not affect FGF2 secretion, suggesting that they are dispensable for this process...
  5. von Deimling M, Häsler R, Steinbach V, Holterhus P, von Spiczak S, Stephani U, et al. Gene expression analysis in untreated absence epilepsy demonstrates an inconsistent pattern. Epilepsy Res. 2017;132:84-90 pubmed publisher
    ..candidate genes with a consistent, but non-significant pattern of up- or down-regulation across all groups (ATP1B3, CAND1, PRPF6, TRIM8)...
  6. Floyd R, Wray S, Quenby S, Martín Vasallo P, Mobasheri A. Expression and distribution of Na, K-ATPase isoforms in the human uterus. Reprod Sci. 2010;17:366-76 pubmed publisher
    ..In pregnancy, there was a switch in isoform expression, resulting in increased beta3 and decreased FXYD2 at the protein and messenger RNA (mRNA) levels. Na, K-ATPase isoform alterations may modulate uterine contractility during labor. ..
  7. Li L, Feng R, Xu Q, Zhang F, Liu T, Cao J, et al. Expression of the ?3 subunit of Na+/K+-ATPase is increased in gastric cancer and regulates gastric cancer cell progression and prognosis via the PI3/AKT pathway. Oncotarget. 2017;8:84285-84299 pubmed publisher
    b>ATP1B3 encodes the ?3 subunit of Na+/K+-ATPase and is located in the q22-23 region of chromosome 3...
  8. Rato S, Rausell A, Munoz M, Telenti A, Ciuffi A. Single-cell analysis identifies cellular markers of the HIV permissive cell. PLoS Pathog. 2017;13:e1006678 pubmed publisher
    ..The combination of CD25 high expression with other candidate biomarkers led to the identification of CD298, CD63 and CD317 as the best biomarkers for permissiveness...
  9. Lu Y, Hou H, Wang F, Qiao L, Wang X, Yu J, et al. ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons. Virology. 2016;496:28-34 pubmed publisher
    ..Human β3 subunit of Na(+)/K(+)-ATPase (ATP1B3) protein was demonstrated to interact with the 3A protein of EV71...

More Information


  1. Nishitsuji H, Sugiyama R, Abe M, Takaku H. ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor κ Light Chain Enhancer of Activated B Cells (NF-κB) Activation by BST-2. J Biol Chem. 2016;291:4754-62 pubmed publisher
    Here, we identify ATP1B3 and fibrillin-1 as novel BST-2-binding proteins...
  2. Mesri M, Birse C, Heidbrink J, McKinnon K, Brand E, Bermingham C, et al. Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues. PLoS ONE. 2013;8:e78885 pubmed publisher
    ..of a panel of the identified targets were confirmed by immunohistochemistry (IHC) including CD146, B7H3, Thy-1 and ATP1B3. To determine if the proteins identified mediate any functional role, we performed siRNA studies which led to ..
  3. Zhao B, Velasco K, Sompallae R, Pfirrmann T, Masucci M, Lindsten K. The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome. Biochem Biophys Res Commun. 2012;427:490-6 pubmed publisher
    ..Thus, the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates. ..
  4. Takahashi Y, Tsuruta S, Honda A, Fujiwara Y, Satoh M, Yasutake A. Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney. J Toxicol Sci. 2012;37:663-6 pubmed
    ..Out of 26,962 rat genes, mercury vapor was found to increase the expression of 1 gene (Atp1b3) and decrease the expression of 1 gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in the ..
  5. Lingrel J, Orlowski J, Shull M, Price E. Molecular genetics of Na,K-ATPase. Prog Nucleic Acid Res Mol Biol. 1990;38:37-89 pubmed
  6. Figtree G, Liu C, Bibert S, Hamilton E, Garcia A, White C, et al. Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009;105:185-93 pubmed publisher
    ..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
  7. Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W. Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells. Tissue Antigens. 2006;68:509-17 pubmed
    ..This mAb was shown to react with the Na, K ATPase beta3 subunit or CD298. By immunofluorescence analysis using mAb P-3E10, it was found that all peripheral blood leukocytes express Na, K ..
  8. Heller M, von der Ohe M, Kleene R, Mohajeri M, Schachner M. The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach. J Neurochem. 2003;84:557-65 pubmed
    ..To our knowledge this is the first report that anti-idiotypic antibodies can be used to identify binding partners for carbohydrates. ..
  9. Chiampanichayakul S, Szekeres A, Khunkaewla P, Moonsom S, Leksa V, Drbal K, et al. Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation. Int Immunol. 2002;14:1407-14 pubmed
    ..By using a retroviral cloning system, the P-3E10 antigen was cloned. Sequence analysis revealed the P-3E10 antigen to be identical to the beta3 subunit of the Na,K-ATPase. ..
  10. Crambert G, Hasler U, Beggah A, Yu C, Modyanov N, Horisberger J, et al. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem. 2000;275:1976-86 pubmed
    ..In conclusion, our study reveals several new functional characteristics of human Na,K-ATPase isozymes which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. ..
  11. Malik N, Canfield V, Sanchez Watts G, Watts A, Scherer S, Beatty B, et al. Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. Mamm Genome. 1998;9:136-43 pubmed
    We have cloned and characterized the Na,K-ATPase beta 3 subunit gene (ATP1B3), and a beta 3 subunit pseudogene (ATP1B3P1), from a human PAC genomic library. The beta 3 subunit gene is > 50 kb in size and is split into 7 exons...
  12. Malik N, Canfield V, Beckers M, Gros P, Levenson R. Identification of the mammalian Na,K-ATPase 3 subunit. J Biol Chem. 1996;271:22754-8 pubmed
    ..Identification of the mammalian beta3 subunit suggests an even greater potential for Na,K-ATPase isoenzyme diversity than previously realized. ..
  13. Jørgensen P. Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase. Biochim Biophys Acta. 1982;694:27-68 pubmed
  14. Aughey R, Murphy K, Clark S, Garnham A, Snow R, Cameron Smith D, et al. Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes. J Appl Physiol (1985). 2007;103:39-47 pubmed
    ..The Na+ -K+ -ATPase mRNA response to interval exercise of increased alpha- but not beta-mRNA was largely preserved posttrain, suggesting a functional role of alpha mRNA upregulation. ..