Gene Symbol: ATP1B2
Description: ATPase Na+/K+ transporting subunit beta 2
Alias: AMOG, sodium/potassium-transporting ATPase subunit beta-2, ATPase, Na+/K+ transporting, beta 2 polypeptide, Na, K-ATPase beta-2 polypeptide, adhesion molecule in glia, adhesion molecule on glia, sodium pump subunit beta-2, sodium-potassium ATPase subunit beta 2 (non-catalytic), sodium/potassium-dependent ATPase beta-2 subunit, sodium/potassium-dependent ATPase subunit beta-2, sodium/potassium-transporting ATPase beta-2 chain
Species: human
Products:     ATP1B2

Top Publications

  1. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..Tetraspanin 13 (TSPAN13), serpin family i member 1 (SERPINI1), ATPase Na+/K+ transporting subunit beta 2 (ATP1B2), nicotinamide nucleotide adenylyl transferase 2 (NMNAT2), platelet-derived growth factor receptor-like (PDGFRL), ..
  2. Leifer I, Melton C, Tratt D, Buckland K, Chang C, Frash J, et al. Validation of mobile in situ measurements of dairy husbandry emissions by fusion of airborne/surface remote sensing with seasonal context from the Chino Dairy Complex. Environ Pollut. 2018;242:2111-2134 pubmed publisher situ concentration and meteorology data were collected for the Chino Dairy Complex in the Los Angeles Basin by AMOG (AutoMObile trace Gas) Surveyor on 25 June 2015 to characterize husbandry emissions in the near and far field in ..
  3. França M, Mesquita F, Lopes E, Pugliesi G, Van Hoeck V, Chiaratti M, et al. Modulation of periovulatory endocrine profiles in beef cows: consequences for endometrial glucose transporters and uterine fluid glucose levels. Domest Anim Endocrinol. 2015;50:83-90 pubmed publisher
    ..05) were detected in gene expression patterns of SLC2A1, SLC2A3, SLC2A4, SLC2A5, SLC5A1, ATP1A2, ATP1B2, and SLC37A4...
  4. Raghunath A, Jeyabaskar D, Sundarraj K, Panneerselvam L, Perumal E. In silico prediction of microRNAs on fluoride induced sperm toxicity in mice. Food Chem Toxicol. 2016;98:34-49 pubmed publisher
    ..miR-511-3p, miR-7b-5p, miR-30e-5p, miR-17-5p, miR-122-5p and miR-541-5p) targeting six genes (Traf3, Rock2, Rgs8, Atp1b2, Cacna2d1 and Aldoa) were already validated experimentally in mice...
  5. Batiuk M, de Vin F, Duque S, Li C, Saito T, Saido T, et al. An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J Biol Chem. 2017;292:8874-8891 pubmed publisher
    ..knockdown assays, immunoblotting, and immunohistochemistry), we identify the ACSA-2 epitope for the first time as ATP1B2 and characterize its distribution in the CNS...
  6. Esmaeel Q, Chevalier M, Chataigne G, Subashkumar R, Jacques P, Leclère V. Nonribosomal peptide synthetase with a unique iterative-alternative-optional mechanism catalyzes amonabactin synthesis in Aeromonas. Appl Microbiol Biotechnol. 2016;100:8453-63 pubmed publisher
    ..A disruption mutant in the adenylation domain of AmoG was unable to synthesize any amonabactin and to grow in iron stress conditions while a deletion of amoH resulted in ..
  7. Mauri N, Kleiter M, Dietschi E, Leschnik M, Högler S, Wiedmer M, et al. A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2). G3 (Bethesda). 2017;7:2729-2737 pubmed publisher
    ..6 Mb interval in whole-genome sequencing data from one affected puppy revealed a 227 bp SINE insertion into the ATP1B2 gene encoding the ?2 subunit of the Na+/K+-ATPase holoenzyme (ATP1B2:c...
  8. Wang K, Gao M, Yang M, Meng F, Li D, Lu R, et al. Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency. Hum Genomics. 2017;11:4 pubmed publisher
    ..The top 10 most up-regulated genes were IGHV1-69, CH17-472G23.1, ATP1B2, FCER2, MUC21, IL13, FCRLB, CLEC5A, FAM124A, and INHBA...
  9. Boer K, Troost D, Timmermans W, Van Rijen P, Spliet W, Aronica E. Pi3K-mTOR signaling and AMOG expression in epilepsy-associated glioneuronal tumors. Brain Pathol. 2010;20:234-44 pubmed publisher
    ..p-p70S6K and p-S6, the effector proteins ERM (ezrin/radixin/moesin) and the pathway regulator AMOG (adhesion molecule on glia) in both GGs and DNTs...

More Information


  1. Rotoli D, Cejas M, Maeso M, Pérez Rodríguez N, Morales M, Avila J, et al. The Na, K-ATPase β-Subunit Isoforms Expression in Glioblastoma Multiforme: Moonlighting Roles. Int J Mol Sci. 2017;18: pubmed publisher
    ..All three isoforms, β1, β2/AMOG (Adhesion Molecule On Glia) and β3, were found to be expressed in GBM samples...
  2. Wu C, Wang Z, Song X, Feng X, Abnet C, He J, et al. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Nat Genet. 2014;46:1001-1006 pubmed publisher
    ..85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21...
  3. Prescott J, Thompson D, Kraft P, Chanock S, Audley T, Brown J, et al. Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. PLoS ONE. 2012;7:e37815 pubmed publisher
    ..Our results suggest that the small magnitude of difference in hormone levels associated with common genetic variants is likely insufficient to detectably contribute to breast cancer risk. ..
  4. Tokhtaeva E, Sachs G, Vagin O. Diverse pathways for maturation of the Na,K-ATPase ?1 and ?2 subunits in the endoplasmic reticulum of Madin-Darby canine kidney cells. J Biol Chem. 2010;285:39289-302 pubmed publisher
    ..Folded ?(1) and ?(2) either assemble with ?(1) or bind BiP. The ?(1)-bound ? subunits traffic to the Golgi, whereas BiP-bound ? subunits are retained and degraded in the ER. ..
  5. Tokhtaeva E, Sachs G, Vagin O. Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum. Biochemistry. 2009;48:11421-31 pubmed publisher
  6. Barwe S, Jordan M, Skay A, Inge L, Rajasekaran S, Wolle D, et al. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009;47:552-60 pubmed publisher
    ..In conclusion, our results demonstrate that Na,K-beta(1) plays an essential role in regulating cardiac contractility and that its loss is associated with significant pathophysiology of the heart. ..
  7. Kung A, Lau K, Cheung W, Chan V. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. Clin Endocrinol (Oxf). 2006;64:158-61 pubmed of the five Na/K-ATPase genes that are expressed in the skeletal muscles, namely ATP1A1, ATP1A2, ATP1B1, ATP1B2 and ATP1B4, were sequenced in all subjects for mutations or polymorphisms...
  8. Hsieh C, Cheng Deutsch A, Gloor S, Schachner M, Francke U. Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17. Somat Cell Mol Genet. 1990;16:401-5 pubmed
    b>AMOG, identified as an adhesion molecule that mediates neuron-astrocyte interaction, has structural similarity to the beta-subunit of Na,K ATPase...
  9. Hernando N, Martin Vasallo P, Ghosh S, Ghosh P, Swaroop A, Coca Prados M. Nucleotide sequence of a cDNA for the beta 2 subunit isoform of Na+,K(+)-ATPase from human retina. Biochim Biophys Acta. 1994;1189:109-11 pubmed
    ..6 kb) is approx. 300 nucleotides larger than the major transcript size expressed in rat (3.3 kb). The larger human size mRNA for the human beta 2 Na+,K(+)-ATPase indicates species differences in gene processing. ..
  10. Ruiz A, Bhat S, Bok D. Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium. Gene. 1996;176:237-42 pubmed
    ..It is therefore reasonable to suggest that both alpha 1 beta 1 and alpha 1 beta 2 heterodimers are present in these cells. ..
  11. De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003;33:192-6 pubmed
    ..Functional data indicate that the putative pathogenetic mechanism is triggered by a loss of function of a single allele of ATP1A2. This is the first report associating mutations of Na+K+ pump subunits to genetic diseases. ..
  12. Crambert G, Hasler U, Beggah A, Yu C, Modyanov N, Horisberger J, et al. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem. 2000;275:1976-86 pubmed
    ..In conclusion, our study reveals several new functional characteristics of human Na,K-ATPase isozymes which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. ..
  13. Geering K, Crambert G, Yu C, Korneenko T, Pestov N, Modyanov N. Intersubunit interactions in human X,K-ATPases: role of membrane domains M9 and M10 in the assembly process and association efficiency of human, nongastric H,K-ATPase alpha subunits (ATP1al1) with known beta subunits. Biochemistry. 2000;39:12688-98 pubmed
  14. Gyedu A, Gaskill C, Boakye G, Abantanga F. Cost-Effectiveness of a Locally Organized Surgical Outreach Mission: Making a Case for Strengthening Local Non-Governmental Organizations. World J Surg. 2017;41:3074-3082 pubmed publisher years (DALY) averted by surgical outreach mission activities of ApriDec Medical Outreach Group (AMOG), a Ghanaian non-governmental organization. The total cost of their activities was also calculated...
  15. Hundal H, Maxwell D, Ahmed A, Darakhshan F, Mitsumoto Y, Klip A. Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle. Mol Membr Biol. 1994;11:255-62 pubmed
    ..The beta 1 subunit was enriched in the PM fraction but was also detected to a modest extent in the IM.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  16. Stengelin M, Hoffman J. Na,K-ATPase subunit isoforms in human reticulocytes: evidence from reverse transcription-PCR for the presence of alpha1, alpha3, beta2, beta3, and gamma. Proc Natl Acad Sci U S A. 1997;94:5943-8 pubmed
    ..The extent to which the kinetic properties of uncoupled sodium efflux might depend on different isoform combinations is not yet known. ..
  17. Avila J, Alvarez de la Rosa D, González Martínez L, Lecuona E, Martin Vasallo P. Structure and expression of the human Na,K-ATPase beta 2-subunit gene. Gene. 1998;208:221-7 pubmed
    ..Watanabe, Y., Araki, M., Nagano, K., 1993). Sp1 binds to the adhesion molecule on glia regulatory element that functions as a positive transcription regulatory element in astrocytes. (J...
  18. Sun M, Kim J, Oh M, Safaee M, Kaur G, Clark A, et al. Na?/K?-ATPase ?2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells. Neuro Oncol. 2013;15:1518-31 pubmed publisher
    ..The ?2-subunit of Na(+)/K(+)-ATPase, called the adhesion molecule on glia (AMOG), is highly expressed in normal glia but is thought to be universally downregulated in GBM...
  19. Friedrich U, Stohr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, et al. The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis. Hum Mol Genet. 2011;20:1132-42 pubmed publisher
    ..A recent proteomic approach identified the Na/K-ATPase subunits ATP1A3 and ATP1B2 as binding partners of retinoschisin...
  20. Mobasheri A, Oukrif D, Dawodu S, Sinha M, Greenwell P, Stewart D, et al. Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization. Histol Histopathol. 2001;16:141-54 pubmed publisher
    ..Na+, K+-ATPase may also regulate lumenal Na+ and K+, major counter-ions for citrate. ..
  21. Boer K, Spliet W, van Rijen P, Jansen F, Aronica E. Expression patterns of AMOG in developing human cortex and malformations of cortical development. Epilepsy Res. 2010;91:84-93 pubmed publisher
    b>Adhesion molecule on glia (AMOG) mediates neuronal migration during development and ion homeostasis. Recently, AMOG has been identified as a regulator of the Pi3K-mTOR signaling pathway...
  22. Floyd R, Wray S, Quenby S, Martín Vasallo P, Mobasheri A. Expression and distribution of Na, K-ATPase isoforms in the human uterus. Reprod Sci. 2010;17:366-76 pubmed publisher
    ..In pregnancy, there was a switch in isoform expression, resulting in increased beta3 and decreased FXYD2 at the protein and messenger RNA (mRNA) levels. Na, K-ATPase isoform alterations may modulate uterine contractility during labor. ..
  23. Figtree G, Liu C, Bibert S, Hamilton E, Garcia A, White C, et al. Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009;105:185-93 pubmed publisher
    ..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
  24. Gloor S, Antonicek H, Sweadner K, Pagliusi S, Frank R, Moos M, et al. The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase. J Cell Biol. 1990;110:165-74 pubmed
    AMOG (adhesion molecule on glia) is a Ca2(+)-independent adhesion molecule which mediates selective neuron-astrocyte interaction in vitro (Antonicek, H., E. Persohn, and M. Schachner. 1987. J. Cell Biol. 104:1587-1595)...
  25. Xu W, Wang C, Liao Z, Zhang Y, Yu L, Wang X, et al. [Identification of interaction and interaction domains between neuroglobin and Na(+), K(+)-ATPase beta2 subunit]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35:823-8 pubmed
    ..Moreover, the structure integrity of neuroglobin was found to be essential for the interaction between NGB and NKA1b2 by yeast two hybrid method with a series of neuroglobin truncated mutants. ..
  26. Chen T, Zhang Y, Xu W, Li Z, Hou B, Wang C, et al. Prokaryotic expression, polyclonal antibody preparation, and sub-cellular localization analysis of Na+, K+-ATPase beta2 subunit. Protein Expr Purif. 2004;37:47-52 pubmed
    ..Results demonstrated that NKA1b2 was localized both in the cytoplasm and cellular membrane. The preparation of anti-NKA-beta2-CP polyclonal antibody will facilitate further functional study on NKA1b2. ..
  27. Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, et al. Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis. Cancer Sci. 2014;105:897-904 pubmed publisher
    ..Interestingly, 8q24.1 (MYC) gain, 9p21.3 (CDKN2A/2B) loss and 17p13 (TP53, ATP1B2, SAT2, SHBG) loss were recurrent genomic lesions among various types of lymphoma with clonal heterogeneity, ..
  28. Cousin P, Billotte J, Chaubert P, Shaw P. Physical map of 17p13 and the genes adjacent to p53. Genomics. 2000;63:60-8 pubmed
    ..Twenty-seven transcription units were identified, including 18 characterized genes. Limited analysis of primary human colon tumors, hemizygous for the p53 gene, indicates loss of the entire 1.1-Mb region upon deletion of wildtype p53. ..
  29. Heller M, von der Ohe M, Kleene R, Mohajeri M, Schachner M. The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach. J Neurochem. 2003;84:557-65 pubmed
    ..To our knowledge this is the first report that anti-idiotypic antibodies can be used to identify binding partners for carbohydrates. ..
  30. Garcia Closas M, Kristensen V, Langerød A, Qi Y, Yeager M, Burdett L, et al. Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer. Int J Cancer. 2007;121:2532-8 pubmed
    ..We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer...
  31. Garcia Closas M, Brinton L, Lissowska J, Richesson D, Sherman M, Szeszenia Dabrowska N, et al. Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study. BMC Cancer. 2007;7:60 pubmed
    ..We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer...
  32. van den Boom J, Wolter M, Blaschke B, Knobbe C, Reifenberger G. Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. Int J Cancer. 2006;119:2330-8 pubmed
    ..These analyses revealed that 5 genes, i.e., AMOG (ATP1B2, 17p13.1), APOD (3q26.2-qter), DMXL1 (5q23.1) DRR1 (TU3A, 3p14...
  33. Martin Vasallo P, Dackowski W, Emanuel J, Levenson R. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. J Biol Chem. 1989;264:4613-8 pubmed
    ..These results suggest that different members of the Na,K-ATPase beta subunit family may have specialized functions. ..
  34. Lingrel J, Orlowski J, Shull M, Price E. Molecular genetics of Na,K-ATPase. Prog Nucleic Acid Res Mol Biol. 1990;38:37-89 pubmed