ATP1B1

Summary

Gene Symbol: ATP1B1
Description: ATPase Na+/K+ transporting subunit beta 1
Alias: ATP1B, sodium/potassium-transporting ATPase subunit beta-1, ATPase, Na+/K+ transporting, beta 1 polypeptide, Beta 1-subunit of Na(+),K(+)-ATPase, Na, K-ATPase beta-1 polypeptide, adenosinetriphosphatase, sodium pump subunit beta-1, sodium-potassium ATPase subunit beta 1 (non-catalytic), sodium/potassium-dependent ATPase beta-1 subunit, sodium/potassium-transporting ATPase beta-1 chain
Species: human
Products:     ATP1B1

Top Publications

  1. Fuller W, Eaton P, Bell J, Shattock M. Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB J. 2004;18:197-9 pubmed
    ..The role of PLM is analogous to phospholamban in regulating the sarcoplasmic reticulum calcium ATPase. ..
  2. Lane L, Shull M, Whitmer K, Lingrel J. Characterization of two genes for the human Na,K-ATPase beta subunit. Genomics. 1989;5:445-53 pubmed
    ..The second class, designated ATP1B, includes 15 overlapping genomic clones and represents a functional gene for the human Na,K-ATPase beta subunit...
  3. Kawakami K, Nojima H, Ohta T, Nagano K. Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit. Nucleic Acids Res. 1986;14:2833-44 pubmed
    ..Total genomic Southern hybridization indicated the existence of only a few, possibly one set of gene encoding the Na,K-ATPase beta-subunit in the human genome. ..
  4. Xiao B, Zhang Y, Niu W, Gao P, Zhu D. Association of ATP1B1 single-nucleotide polymorphisms with blood pressure and hypertension in a Chinese population. Clin Chim Acta. 2009;407:47-50 pubmed publisher
    b>ATP1B1 encodes the beta subunits of Na/K ATPase which plays an important role in maintaining the normal gradients of Na(+) and K(+) across plasma membrane...
  5. Barwe S, Jordan M, Skay A, Inge L, Rajasekaran S, Wolle D, et al. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009;47:552-60 pubmed publisher
    ..In conclusion, our results demonstrate that Na,K-beta(1) plays an essential role in regulating cardiac contractility and that its loss is associated with significant pathophysiology of the heart. ..
  6. Faruque M, Chen G, Doumatey A, Huang H, Zhou J, Dunston G, et al. Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. J Hypertens. 2011;29:1906-12 pubmed publisher
    ..We examined polymorphisms in three of these genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans...
  7. Lanciotti A, Brignone M, Molinari P, Visentin S, De Nuccio C, Macchia G, et al. Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations. Hum Mol Genet. 2012;21:2166-80 pubmed publisher
    ..These data demonstrate, for the first time, that MLC1 plays a role in astrocyte osmo-homeostasis and that defects in intracellular calcium dynamics may contribute to MLC pathogenesis. ..
  8. Cochrane D, Jacobsen B, Connaghan K, Howe E, Bain D, Richer J. Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer. Mol Cell Endocrinol. 2012;355:15-24 pubmed publisher
    ..repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1)...
  9. Ma C, de Baaij J, Millar P, Gault V, De Galan B, Bindels R, et al. Effect of Dapagliflozin Treatment on the Expression of Renal Sodium Transporters/Channels on High-Fat Diet Diabetic Mice. Nephron. 2019;:1-10 pubmed publisher
    ..Na+/K+-ATPase (Atp1b1) expression was also increased significantly by dapagliflozin treatment, but it did not affect Atp1a1 and glucose ..

More Information

Publications114 found, 100 shown here

  1. Beguin P, Crambert G, Monnet Tschudi F, Uldry M, Horisberger J, Garty H, et al. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. EMBO J. 2002;21:3264-73 pubmed
    ..These data suggest that FXYD7 is a novel, tissue- and isoform-specific Na,K-ATPase regulator which could play an important role in neuronal excitability. ..
  2. Taub M, Springate J, Cutuli F. Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase. Biochem Biophys Res Commun. 2010;393:339-44 pubmed publisher
    ..Once phosphorylated, TORCs enter the nucleus, and activate transcription of the ATP1B1 gene encoding for the Na,K-ATPase beta subunit.
  3. Smith J, Avery C, Evans D, Nalls M, Meng Y, Smith E, et al. Impact of ancestry and common genetic variants on QT interval in African Americans. Circ Cardiovasc Genet. 2012;5:647-55 pubmed publisher
    ..10(-8)) were identified with SNPs at 2 loci, upstream of the genes NOS1AP (rs12143842, P=2 × 10(-15)) and ATP1B1 (rs1320976, P=2 × 10(-10))...
  4. Mladinov D, Liu Y, Mattson D, Liang M. MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1. Nucleic Acids Res. 2013;41:1273-83 pubmed publisher
    ..miR-192 and its predicted target the β-1 subunit of Na(+)/K(+)-ATPase (Atp1b1), an enzyme providing the driving force for tubular transport, were inversely enriched in kidney regions...
  5. Tomic A, Dobricić V, Novakovic I, Svetel M, Pekmezovic T, Kresojević N, et al. Mutational analysis of ATP7B gene and the genotype-phenotype correlation in patients with Wilson's disease in Serbia. Vojnosanit Pregl. 2013;70:457-62 pubmed
    ..3 chromosome, contains 21 exons and codes for copper specific transporting P-type adenosinetriphosphatase (ATPase) (ATP7B)...
  6. Theofilidis G, Bogdanis G, Koutedakis Y, Karatzaferi C. Monitoring Exercise-Induced Muscle Fatigue and Adaptations: Making Sense of Popular or Emerging Indices and Biomarkers. Sports (Basel). 2018;6: pubmed publisher
    ..intensity and duration and may range from substrate depletion to acidosis and product inhibition of adenosinetriphosphatase (ATPase) and glycolysis...
  7. Capaia M, Granata I, Guarracino M, Petretto A, Inglese E, Cattrini C, et al. A hnRNP K⁻AR-Related Signature Reflects Progression toward Castration-Resistant Prostate Cancer. Int J Mol Sci. 2018;19: pubmed publisher
    ..we identified 51 proteins differentially interacting with hnRNP K, among which KLK3, SORD, SPON2, IMPDH2, ACTN4, ATP1B1, HSPB1, and KHDRBS1 were associated with AR and differentially expressed in normal and tumor human prostate ..
  8. Vagin O, Turdikulova S, Sachs G. Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells. J Biol Chem. 2005;280:43159-67 pubmed
  9. Wen H, Liu L, Zhan L, Liang D, Li L, Liu D, et al. Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases. Cell Death Dis. 2018;9:635 pubmed publisher
    ..We further showed that HPC increased the membranous level of Na+/K+ ATPases ?1 subunit (Atp1b1) in CA1 after tGCI...
  10. Baranowski Ł, Rozanska E, Sańko Sawczenko I, Matuszkiewicz M, Znojek E, Filipecki M, et al. Arabidopsis tonoplast intrinsic protein and vacuolar H+-adenosinetriphosphatase reflect vacuole dynamics during development of syncytia induced by the beet cyst nematode Heterodera schachtii. Protoplasma. 2019;256:419-429 pubmed publisher
    ..electron microscopy of syncytia localised the vacuolar markers E subunit of vacuolar H+-adenosinetriphosphatase (V-ATPase) complex and tonoplast intrinsic protein (γ-TIP1;1) mostly in membranes surrounding syncytial ..
  11. Zatyka M, Ricketts C, Da Silva Xavier G, Minton J, Fenton S, Hofmann Thiel S, et al. Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. Hum Mol Genet. 2008;17:190-200 pubmed
  12. Rabea E, Nasr H, Badawy M, El Gendy I. Toxicity of naturally occurring Bio-fly and chitosan compounds to control the Mediterranean fruit fly Ceratitis capitata (Wiedemann). Nat Prod Res. 2015;29:460-5 pubmed publisher
    ..The inhibitory effects on acetylcholinesterase (AChE) and adenosinetriphosphatase (ATPase) as biochemical indicators were also determined in vivo. The results indicated that B...
  13. Liu Y, Chen S, Chen X, Zhang J, Gao B. Interactions between Microcystis aeruginosa and coexisting amoxicillin contaminant at different phosphorus levels. J Hazard Mater. 2015;297:83-91 pubmed publisher
    ..triphosphate (ATP) and malondialdehyde, the expression of psbA and rbcL, as well as the activities of adenosinetriphosphatase and glutathione S-transferase in similar manners, but regulated the production and release of ..
  14. Nair B, Johar K, Priya A, Wong Riley M. Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons. Biochim Biophys Acta. 2016;1863:1-9 pubmed publisher
    ..It also regulates Atp1a1 and Atp1b1 subunit genes of Na(+)/K(+)-ATPase, a major energy-consuming enzyme, as well as all 13 subunits of cytochrome c ..
  15. Nakashima A, Kawamoto T, Noshiro M, Ueno T, Doi S, Honda K, et al. Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure. Hypertension. 2018;72:746-754 pubmed publisher
    ..Here, we show that DEC1 suppressed the expression of ATP1B1, which encodes the β1 subunit of the Na+/K+-ATPase and elevated blood pressure...
  16. Wang C, Ruan R, Zhang L, Zhang Y, Zhou W, Lin J, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015;12:1259-67 pubmed publisher
    In this work, we discovered that the Na(+)/K(+)-ATPase beta-subunit (ATP1B1) on epidermal cells plays a key role in the peptide-mediated transdermal delivery of macromolecular drugs...
  17. Shi W, Xu G, Wang C, Sperber S, Chen Y, Zhou Q, et al. Heat shock 70-kDa protein 5 (Hspa5) is essential for pronephros formation by mediating retinoic acid signaling. J Biol Chem. 2015;290:577-89 pubmed publisher
    ..the reduction of pronephric marker genes Lim homeobox protein 1 (lhx1), pax2, and β1 subunit of Na/K-ATPase (atp1b1). Pronephros tissue was induced in vitro by treating animal caps with all-trans-retinoic acid and activin...
  18. Guo W, Lian S, Zhen L, Zang S, Chen Y, Lang L, et al. The Favored Mechanism for Coping with Acute Cold Stress: Upregulation of miR-210 in Rats. Cell Physiol Biochem. 2018;46:2090-2102 pubmed publisher
    ..were collected for qRT-PCR and western blot analyses to detect relative expression of rno-miR-210-3p, ISCU, Rap1b, ATP1b1, GPD1, E2F3, RAD52, PSMB6 and GPD2...
  19. Zacherl S, La Venuta G, Muller H, Wegehingel S, Dimou E, Sehr P, et al. A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2. J Biol Chem. 2015;290:3654-65 pubmed publisher
    ..As opposed to ATP1A1, down-regulation of the β1- and β3-chains (ATP1B1 and ATP1B3) of the Na/K-ATPase did not affect FGF2 secretion, suggesting that they are dispensable for this ..
  20. Generous A, Thorson M, Barcus J, Jacher J, Busch M, Sleister H. Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins. Virol J. 2014;11:228 pubmed publisher
    ..CKAP5), potassium channel formation (KCTD9), zinc transporter function (SLC30A9), Na+/K+ ATPase function (ATP1B1), and RNA splicing (TRA2B). Ten human proteins were identified as interacting with IAV NP in a Y2H screen...
  21. Liu Y, Sowell S, Luo Y, Chaubey A, Cameron R, Kim H, et al. Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment. PLoS ONE. 2015;10:e0123106 pubmed publisher
    ..interacts with brain expressed proteins MAP1B and MYO16 and its intracellular domain can potentially interact with ATP1B1, UFC1, and SHMT2...
  22. Čechová P, Berka K, Kubala M. Ion Pathways in the Na+/K+-ATPase. J Chem Inf Model. 2016;56:2434-2444 pubmed publisher
  23. Ushkaryov YuA -, Monastyrskaya G, Broude N, Nikiforova N, Bessarab D, Orlova MYu -, et al. Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene. FEBS Lett. 1989;257:439-42 pubmed
    ..The structure of a pseudogene (beta psi) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the beta I-subunit cDNA from HeLa cells is about 88%. ..
  24. Araki N, Ishigami T, Ushio H, Minegishi S, Umemura M, Miyagi Y, et al. Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L. Biochem Biophys Res Commun. 2009;388:290-6 pubmed publisher
    ..NPC2 might regulate sodium reabsorption in the terminal nephron by interacting with ENaC-Nedd4L system. ..
  25. Floyd R, Wray S, Quenby S, Martín Vasallo P, Mobasheri A. Expression and distribution of Na, K-ATPase isoforms in the human uterus. Reprod Sci. 2010;17:366-76 pubmed publisher
    ..In pregnancy, there was a switch in isoform expression, resulting in increased beta3 and decreased FXYD2 at the protein and messenger RNA (mRNA) levels. Na, K-ATPase isoform alterations may modulate uterine contractility during labor. ..
  26. Ashbrook A, Lentscher A, Zamora P, Silva L, May N, Bauer J, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio. 2016;7: pubmed publisher
    ..Our study describes the potent inhibition of Chikungunya virus and related alphaviruses by the cardiac glycoside digoxin and demonstrates a function for the sodium-potassium ATPase in Chikungunya virus infection. ..
  27. Sieck G, Zhan W, Prakash Y, Daood M, Watchko J. SDH and actomyosin ATPase activities of different fiber types in rat diaphragm muscle. J Appl Physiol (1985). 1995;79:1629-39 pubmed
    ..Succinate dehydrogenase (SDH) and calcium-activated myosin adenosinetriphosphatase (actomyosin ATPase) activities were measured with quantitative histochemical procedures...
  28. Oakey R, Watson M, Seldin M. Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA. Hum Mol Genet. 1992;1:613-20 pubmed
    ..These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci. ..
  29. Ruiz A, Bhat S, Bok D. Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium. Gene. 1995;155:179-84 pubmed
  30. Buschow S, van Balkom B, Aalberts M, Heck A, Wauben M, Stoorvogel W. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol Cell Biol. 2010;88:851-6 pubmed publisher
    ..These include HSC71, HSP90, 14-3-3?, CD20 and pyruvate kinase type M2 (PKM2), and we speculate on the functionality of their interaction with exosomal MHC II. ..
  31. Lee S, Litan A, Li Z, Graves B, Lindsey S, Barwe S, et al. Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Mol Cancer. 2015;14:159 pubmed publisher
    ..Na,K-ATPase β1-subunit is a target of the Shh signaling pathway and loss of β1-subunit expression may contribute to tumor development and progression not only in carcinoma but also in medulloblastoma, a tumor of neuronal origin. ..
  32. Wang J, Zhou F, Wang D, Li J, Lu D, Li Q, et al. Interaction of DCF1 with ATP1B1 induces impairment in astrocyte structural plasticity via the P38 signaling pathway. Exp Neurol. 2018;302:214-229 pubmed publisher
    ..Immunoprecipitation-mass spectrometry (IP-Mass) identified that ATP1B1 is bound to DCF1, and co-immunoprecipitation and cell fluorescence further confirmed an interaction between these ..
  33. Selvakumar P, Owens T, David J, Petrelli N, Christensen B, Lakshmikuttyamma A, et al. Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma. Epigenetics. 2014;9:579-86 pubmed publisher
    ..We hypothesized that DNA methylation plays a role in silencing the NaK-β gene (ATP1B1) expression in kidney cancers...
  34. Guan L, Tan J, Li H, Jin X. Biomarker identification in clear cell renal cell carcinoma based on miRNA-seq and digital gene expression-seq data. Gene. 2018;647:205-212 pubmed publisher
    ..regulation network revealed that CCND1 was the common target gene of miRNA-429, miRNA-206, and miRNA-184, and ATP1B1 was the common target gene of miRNA-140-3p and miRNA-142-5p...
  35. Wu K, Lytton J. Molecular cloning and quantification of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in rat muscles. Am J Physiol. 1993;264:C333-41 pubmed
    A cDNA encoding the full-length adult rat fast-twitch muscle Ca(2+)-adenosinetriphosphatase (ATPase) was cloned...
  36. Tummala R, Wolle D, Barwe S, Sampson V, Rajasekaran A, Pendyala L. Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin. Cancer Chemother Pharmacol. 2009;64:1187-94 pubmed publisher
    ..This study suggests a potentially important role for Na,K-beta(1) in both prognosis and therapy of oxaliplatin resistant malignancies. ..
  37. Ventura N, Jin A, Tse M, Peterson N, Andrew R, Mewburn J, et al. Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring. Mol Cell Biochem. 2015;408:223-33 pubmed publisher
    ..Gene expression of Na(+)/K(+) ATPase channel isoforms, Atp1a1, Atp1a3, and Atp1b1, displayed no significant differences...
  38. Qi Y, Liu K, Zhang J, Li K, Ren J, Lin P. [Synergic effect of Na(+)-K(+) ATPaseB1 and adriamycin on inhibition of cell proliferation and reversal of drug resistance in breast cancer MCF-7 cells]. Ai Zheng. 2009;28:861-7 pubmed
    ..Expression of its B1 subunit gene-ATP1B1 is high in well differentiated and low in poorly differentiated tumor cells...
  39. Bab Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk K, Karlish S. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009;48:8684-91 pubmed publisher
    ..In the light of these findings, we discuss its role in cell adhesion and recognition of the beta subunits of Na,K-ATPase, including potential protein partners. ..
  40. Adav S, Qian J, Ang Y, Kalaria R, Lai M, Chen C, et al. iTRAQ quantitative clinical proteomics revealed role of Na(+)K(+)-ATPase and its correlation with deamidation in vascular dementia. J Proteome Res. 2014;13:4635-46 pubmed publisher
    ..Our findings suggest impaired regulation and compromised activity of ion channel proteins contribute to the pathophysiology of VaD. ..
  41. Taub M, Garimella S, Kim D, Rajkhowa T, Cutuli F. Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. Cell Signal. 2015;27:2568-78 pubmed publisher
    ..The same signaling pathways also control the transcription of the Na,K-ATPase β subunit gene atp1b1 in renal proximal tubule cells...
  42. Singh H, Linas S. Beta 2-adrenergic function in cultured rat proximal tubule epithelial cells. Am J Physiol. 1996;271:F71-7 pubmed
    ..Thus cultured cells maintain apical Na/H antiport and basolateral Na-K-adenosinetriphosphatase (Na-K-ATPase)...
  43. Roy R, Singh R, Chattopadhyay E, Ray A, Sarkar N, Aich R, et al. MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues. Gene. 2016;593:58-63 pubmed publisher
    ..Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types ..
  44. Afshari N, Igo R, Morris N, Stambolian D, Sharma S, Pulagam V, et al. Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun. 2017;8:14898 pubmed publisher
    ..loci meeting genome-wide significance (P<5 × 10-8): KANK4 rs79742895, LAMC1 rs3768617 and LINC00970/ATP1B1 rs1200114. We also observe an overwhelming effect of the established TCF4 locus...
  45. Pfeufer A, Sanna S, Arking D, Müller M, Gateva V, Fuchsberger C, et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009;41:407-14 pubmed publisher
    ..Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within ..
  46. Shi J, Fu L, Ang Q, Wang G, Zhu J, Wang W. Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia. Oncotarget. 2016;7:2585-95 pubmed publisher
    b>ATP1B1 encodes the Na,K-ATPase β subunit, a key regulator of the Na+ and K+ electrochemical gradients across the plasma membrane and an essential regulator of cellular activity...
  47. Rosignolo F, Sponziello M, Durante C, Puppin C, Mio C, Baldan F, et al. Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma. PLoS ONE. 2016;11:e0156658 pubmed publisher
    ..b>ATP1B1, GPC3, KCNIP3, and PRLR transcript levels in tumor tissues were significantly lower in PTCs than in NT, whereas ..
  48. Mobasheri A, Oukrif D, Dawodu S, Sinha M, Greenwell P, Stewart D, et al. Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization. Histol Histopathol. 2001;16:141-54 pubmed publisher
    ..Na+, K+-ATPase may also regulate lumenal Na+ and K+, major counter-ions for citrate. ..
  49. Goldenring J, Soroka C, Shen K, Tang L, Rodriguez W, Vaughan H, et al. Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells. Am J Physiol. 1994;267:G187-94 pubmed
    Parietal cell secretion of acid requires the coordinated fusion of H(+)-K(+)-adenosinetriphosphatase (ATPase)-containing tubulovesicles with a secretory canalicular target membrane...
  50. Harrer J, Haghighi K, Kim H, Ferguson D, Kranias E. Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart. Am J Physiol. 1997;272:H57-66 pubmed
    Phospholamban, the regulator of Ca(2+)-adenosinetriphosphatase (ATPase) activity in cardiac sarcoplasmic reticulum (SR), is an important determinant of basal myocardial performance...
  51. Feraille E, Doucet A. Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. Physiol Rev. 2001;81:345-418 pubmed
  52. Lingrel J, Orlowski J, Shull M, Price E. Molecular genetics of Na,K-ATPase. Prog Nucleic Acid Res Mol Biol. 1990;38:37-89 pubmed
  53. Booth J, McKenna M, Ruell P, Gwinn T, Davis G, Thompson M, et al. Impaired calcium pump function does not slow relaxation in human skeletal muscle after prolonged exercise. J Appl Physiol (1985). 1997;83:511-21 pubmed
    ..human quadriceps muscle contractile function and homogenate sarcoplasmic reticulum Ca2+ uptake and Ca2+-adenosinetriphosphatase activity. Ten untrained men cycled at 75 +/- 2% (SE) peak oxygen consumption until exhaustion...
  54. Swick L, Kapatos G. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. J Neurochem. 2006;97:1447-55 pubmed
  55. Brignone M, Lanciotti A, Macioce P, Macchia G, Gaetani M, Aloisi F, et al. The beta1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis. Hum Mol Genet. 2011;20:90-103 pubmed publisher
  56. Suñé G, Sarró E, Puigmulé M, López Hellín J, Zufferey M, Pertel T, et al. Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney. PLoS ONE. 2010;5:e13930 pubmed publisher
  57. Wang N, Xu R, Chen X, Hu W. [The role of ouabain in cell death of vascular endothelial cells ECV304 and the changes of expression of Na+, K(+)-ATPase alpha1, beta1-subunit]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008;24:177-83 pubmed
    ..Ouabain could up-regulate Na+, K(+)-ATPase alpha1-Subunit expression and reduce beta1-Subunit expression which mediated signal transduction and decreased cell-cell adhesions and induced ECV304 cells death. ..
  58. Cirri E, Katz A, Mishra N, Belogus T, Lifshitz Y, Garty H, et al. Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions. Biochemistry. 2011;50:3736-48 pubmed publisher
    ..In whole cell expression studies FXYD1 reduces the apparent affinity for Na ions. Possible reasons for the difference from this study using the purified recombinant Na,K-ATPase are discussed. ..
  59. Zhao B, Velasco K, Sompallae R, Pfirrmann T, Masucci M, Lindsten K. The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome. Biochem Biophys Res Commun. 2012;427:490-6 pubmed publisher
    ..Thus, the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates. ..
  60. Johar K, Priya A, Wong Riley M. Regulation of Na(+)/K(+)-ATPase by nuclear respiratory factor 1: implication in the tight coupling of neuronal activity, energy generation, and energy consumption. J Biol Chem. 2012;287:40381-90 pubmed publisher
    ..analysis, and real-time quantitative PCR, NRF-1 was found to functionally bind to the promoters of Atp1a1 and Atp1b1 genes but not of the Atp1a3 gene in neurons...
  61. Avery C, Wassel C, Richard M, Highland H, Bien S, Zubair N, et al. Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations. Heart Rhythm. 2017;14:572-580 pubmed publisher
    ..Through sequential conditional analysis we also identified three trans-ethnic novel SNPs at ATP1B1, SCN5A-SCN10A, and KCNQ1 and three Hispanic/Latino-specific novel SNPs at NOS1AP and SCN5A-SCN10A (two novel SNPs) ..
  62. Wall S, Fischer M, Kim G, Nguyen B, Hassell K. In rat inner medullary collecting duct, NH uptake by the Na,K-ATPase is increased during hypokalemia. Am J Physiol Renal Physiol. 2002;282:F91-102 pubmed
    ..In conclusion, with 3 days of K(+) restriction, NH uptake by Na,K-ATPase is increased in the tIMCD primarily from the reduced interstitial K(+) concentration...
  63. Li Y, Yang J, Li S, Zhang J, Zheng J, Hou W, et al. N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K+-ATPase. J Biol Chem. 2011;286:32289-99 pubmed publisher
    ..Our results demonstrate that estrogen/NDRG2/Na(+)/K(+)-ATPase ?1 pathway is important in promoting Na(+)/K(+)-ATPase activity and suggest this novel pathway might have substantial roles in ion transport, fluid balance, and homeostasis. ..
  64. Howard A, Legon S, Walters J. Human and rat intestinal plasma membrane calcium pump isoforms. Am J Physiol. 1993;265:G917-25 pubmed
    The intestinal basolateral membrane Ca(2+)-transporting adenosinetriphosphatase is the energy-dependent step in the absorption of dietary Ca2+ by the vitamin D-dependent transcellular pathway...
  65. Ono S, Guntupalli J, DuBose T. Role of H(+)-K(+)-ATPase in pHi regulation in inner medullary collecting duct cells in culture. Am J Physiol. 1996;270:F852-61 pubmed
    ..in primary culture have proposed two mechanisms for Na(+)-independent hydrogen ion transport: an H(+)-adenosinetriphosphatase (H(+)-ATPase) and an H(+)-K(+)-ATPase...
  66. Blau S, Daly L, Fienberg A, Teitelman G, Ehrlich M. DARPP-32 promoter directs transgene expression to renal thick ascending limb of loop of Henle. Am J Physiol. 1995;269:F564-70 pubmed
    ..by dopamine and other first messengers, and in this form inhibits the activity of the Na(+)-K(+)-adenosinetriphosphatase pump. For functional analysis of the DARPP-32 promoter in the kidney, we characterized the murine gene...
  67. Coca Prados M, Fernandez Cabezudo M, Sanchez Torres J, Crabb J, Ghosh S. Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium. Invest Ophthalmol Vis Sci. 1995;36:2717-28 pubmed
    ..The restricted cellular distribution of beta 2 isoform within the NPE cells represents an important differential gene marker associated with the multiple alpha subunit isoforms of Na+,K(+)-ATPase. ..
  68. Ahn K, Kone B. Expression and cellular localization of mRNA encoding the "gastric" isoform of H(+)-K(+)-ATPase alpha-subunit in rat kidney. Am J Physiol. 1995;268:F99-109 pubmed
    The distribution of transcripts encoding the gastric H(+)-K(+)-adenosinetriphosphatase (ATPase) alpha-subunit in the normal rat kidney was studied by reverse transcription-polymerase chain reaction (RT-PCR), combined with DNA sequence ..
  69. Callaghan J, Tan S, Khan M, Curran K, Campbell W, Smolka A, et al. Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit. Am J Physiol. 1995;268:F363-74 pubmed
    The gastric mucosal parietal cells and cells of the renal collecting duct both possess H(+)-K(+)-adenosinetriphosphatase (H(+)-K(+)-ATPase) activities. In the stomach, the H(+)-K(+)-ATPase (EC 3.6.1...
  70. Prunet P, Pisam M, Claireaux J, Boeuf G, Rambourg A. Effects of growth hormone on gill chloride cells in juvenile Atlantic salmon (Salmo salar). Am J Physiol. 1994;266:R850-7 pubmed
    ..showing a poor ability to adapt themselves to seawater life, GH significantly increased gill Na(+)-K(+)-adenosinetriphosphatase activity as well as gill sodium efflux into seawater...
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    ..Immunofluorescent localization of the anion exchanger AE1 and of the 56-kDa subunit of the vacuolar H(+)-adenosinetriphosphatase (H(+)-ATPase) was used to identify intercalated cells, while the AQP2 water channel was used as a ..
  72. Crambert G, Hasler U, Beggah A, Yu C, Modyanov N, Horisberger J, et al. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem. 2000;275:1976-86 pubmed
    ..In conclusion, our study reveals several new functional characteristics of human Na,K-ATPase isozymes which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. ..
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    Changes in the levels of mRNAs encoding ion transporters (ATP1B1, NHE1, NKCC1), beta-actin, GAPDH, regulators of proliferation and apoptosis (p53, Bcl-2) and kinase hSGK, involved in cell water regulation, were studied using RT PCR in the ..
  74. Kung A, Lau K, Cheung W, Chan V. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. Clin Endocrinol (Oxf). 2006;64:158-61 pubmed
    ..start site of the five Na/K-ATPase genes that are expressed in the skeletal muscles, namely ATP1A1, ATP1A2, ATP1B1, ATP1B2 and ATP1B4, were sequenced in all subjects for mutations or polymorphisms...
  75. Matlhagela K, Taub M. Regulation of the Na-K-ATPase beta(1)-subunit promoter by multiple prostaglandin-responsive elements. Am J Physiol Renal Physiol. 2006;291:F635-46 pubmed
    ..The results of these studies are indicative of a synergism between Sp1 and CREB in mediating regulation by PGRE3; while regulation occurring through PGRE1 also involves Sp1 and CREB, the mechanism appears to be distinct. ..
  76. Wu S, Kim J, Bandle R, Liotta L, Petricoin E, Karger B. Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA). Mol Cell Proteomics. 2006;5:1610-27 pubmed
    ..This work demonstrates that comprehensive characterization provides a powerful tool to aid in the study of important therapeutic targets. The detailed molecular information will prove useful in future studies in tissue. ..
  77. Yoshimura S, Iwasaka S, Schwarz W, Takeyasu K. Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells. J Cell Sci. 2008;121:2159-68 pubmed publisher
    ..All these results indicate that the alpha- and beta-subunits of Na(+)/K(+)-ATPase are assembled in the endoplasmic reticulum, but are disassembled in the plasma membrane and undergo different degradation processes. ..
  78. Liu K, Zhang J, Ren J, Wang X, Yang H, Lin P. [Interference of human Na/K-ATPase B1 subunit on proliferation and migration of gastric adenocarcinoma cell line SGC-7901]. Ai Zheng. 2009;28:225-31 pubmed
    The Na+/K+ ATPase B1 (ATP1B1) subunit gene is highly expressed in well-differentiated tumor cells, while it is hypoexpressed in poorly differentiated tumor cells...
  79. Tokhtaeva E, Sachs G, Souda P, Bassilian S, Whitelegge J, Shoshani L, et al. Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase ?? subunits. J Biol Chem. 2011;286:25801-12 pubmed publisher
    ..Therefore, interactions between the ?? subunits of neighboring cells maintain integrity of intercellular junctions, and alterations in the ?? subunit N-glycan structure can regulate stability and tightness of intercellular junctions. ..
  80. Poulsen H, Nissen P, Mouritsen O, Khandelia H. Protein kinase A (PKA) phosphorylation of Na+/K+-ATPase opens intracellular C-terminal water pathway leading to third Na+-binding site in molecular dynamics simulations. J Biol Chem. 2012;287:15959-65 pubmed publisher
    ..The results establish a structural association of Ser(936) with the C terminus of NKA and indicate that phosphorylation of Ser(936) can modulate pumping activity by changing the accessibility to the ion-binding site. ..
  81. Sano M, Kamitsuji S, Kamatani N, Hong K, Han B, Kim Y, et al. Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. Hum Mol Genet. 2014;23:6668-76 pubmed publisher
    ..Our findings support a functional role of sodium-calcium exchanger in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models. ..
  82. López S, Buil A, Souto J, Casademont J, Martinez Perez A, Almasy L, et al. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. Mitochondrion. 2014;18:34-40 pubmed publisher
    ..Both genes have a role in mitochondrial biogenesis and are potential candidates for the sex-specific control of mtDNA levels. ..
  83. Park S, Choi H, Jo S, Seo J, Han E, Choi K, et al. YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5. Biochim Biophys Acta. 2015;1853:1060-72 pubmed publisher
    ..Our findings uncovered an apoptotic signaling cascade linking YAF2, PDCD5, and TP53 during genotoxic stress responses. ..
  84. Tokhtaeva E, Sun H, Deiss Yehiely N, Wen Y, Soni P, Gabrielli N, et al. The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits. J Cell Sci. 2016;129:2394-406 pubmed publisher
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    ..and clear cells in the body and tail of the epididymis express high levels of a vacuolar proton-pumping adenosinetriphosphatase on their apical plasma membranes and on intracellular vesicles...
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    ..These results suggest that different members of the Na,K-ATPase beta subunit family may have specialized functions. ..
  87. Sverdlov E, Broude N, Sverdlov V, Monastyrskaya G, Grishin A, Petrukhin K, et al. Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. FEBS Lett. 1987;221:129-33 pubmed
    ..In addition, the tissue specificity of the expression of different genes of the family of Na+,K+-ATPase genes and their low expression in tumor cells have been demonstrated. ..
  88. Crump R, Askew G, Wert S, Lingrel J, Joiner C. In situ localization of sodium-potassium ATPase mRNA in developing mouse lung epithelium. Am J Physiol. 1995;269:L299-308 pubmed
    The ontogeny of Na(+)-K(+)-adenosinetriphosphatase (ATPase) mRNA in the mouse lung was examined, using alpha- and beta-isoform-specific probes in Northern blot assays and for in situ hybridization analysis...
  89. Davies S, Huesmann G, Maddrell S, O Donnell M, Skaer N, Dow J, et al. CAP2b, a cardioacceleratory peptide, is present in Drosophila and stimulates tubule fluid secretion via cGMP. Am J Physiol. 1995;269:R1321-6 pubmed
    ..CAP2b and cGMP increase transepithelial potential difference, suggesting that stimulation of vacuolar-adenosinetriphosphatase action underlies the corresponding increases in fluid secretion...
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    ..In the presence of the Na(+)-K(+)-adenosinetriphosphatase inhibitor ouabain, Ip was not reduced, and the effects of the heavy metals were maintained...
  91. Heller M, von der Ohe M, Kleene R, Mohajeri M, Schachner M. The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach. J Neurochem. 2003;84:557-65 pubmed
    ..To our knowledge this is the first report that anti-idiotypic antibodies can be used to identify binding partners for carbohydrates. ..
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    ..Otherwise, the alpha/beta complex is destined for degradation. ..