ATP1A1

Summary

Gene Symbol: ATP1A1
Description: ATPase Na+/K+ transporting subunit alpha 1
Alias: sodium/potassium-transporting ATPase subunit alpha-1, ATPase, Na+/K+ transporting, alpha 1 polypeptide, Na(+)/K(+) ATPase alpha-1 subunit, Na+/K+ ATPase 1, Na, K-ATPase, alpha-A catalytic polypeptide, Na,K-ATPase alpha-1 subunit, Na,K-ATPase catalytic subunit alpha-A protein, sodium pump subunit alpha-1, sodium-potassium ATPase catalytic subunit alpha-1, sodium-potassium-ATPase, alpha 1 polypeptide
Species: human
Products:     ATP1A1

Top Publications

  1. Herrera V, Ruiz Opazo N. Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution. Science. 1990;249:1023-6 pubmed
  2. Ruiz Opazo N, Barany F, Hirayama K, Herrera V. Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Hypertension. 1994;24:260-70 pubmed
    ..This identifies a site- and nucleotide-specific Taq polymerase misincorporation, suggesting that a structural basis might underlie a predisposition to nonrandom Taq polymerase errors. ..
  3. Glorioso N, Filigheddu F, Troffa C, Soro A, Parpaglia P, Tsikoudakis A, et al. Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Hypertension. 2001;38:204-9 pubmed
    ..Based on our observations that alpha(1)-Na,K-ATPase (ATP1A1) and renal-specific, bumetanide-sensitive Na,K,2Cl-cotransporter (NKCC2) genes interactively increase ..
  4. Beguin P, Crambert G, Monnet Tschudi F, Uldry M, Horisberger J, Garty H, et al. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. EMBO J. 2002;21:3264-73 pubmed
    ..These data suggest that FXYD7 is a novel, tissue- and isoform-specific Na,K-ATPase regulator which could play an important role in neuronal excitability. ..
  5. Ogawa H, Toyoshima C. Homology modeling of the cation binding sites of Na+K+-ATPase. Proc Natl Acad Sci U S A. 2002;99:15977-82 pubmed
    ..Our models readily explain many mutational and biochemical results, including different binding stoichiometry and affinities for Na+ and K+. ..
  6. Dostanic Larson I, Van Huysse J, Lorenz J, Lingrel J. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A. 2005;102:15845-50 pubmed
    ..Taken together these results demonstrate that the cardiac glycoside binding site of the alpha isoforms of the Na,K-ATPase have a physiological function and supports the hypothesis for a role of the endogenous cardiac glycosides...
  7. Glorioso N, Herrera V, Bagamasbad P, Filigheddu F, Troffa C, Argiolas G, et al. Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects. Circ Res. 2007;100:1522-9 pubmed
    ..As a complex multifactorial disease, elucidation of susceptibility loci remains elusive. ATP1A1 and Dear are candidate genes for 2 closely linked rat chromosome-2 blood pressure quantitative trait loci...
  8. Fejes Toth G, Rusvai E, Longo K, Naray Fejes Toth A. Expression of colonic H-K-ATPase mRNA in cortical collecting duct: regulation by acid/base balance. Am J Physiol. 1995;269:F551-7 pubmed
    ..abstract truncated at 250 words)..
  9. Cirri E, Katz A, Mishra N, Belogus T, Lifshitz Y, Garty H, et al. Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions. Biochemistry. 2011;50:3736-48 pubmed publisher
    ..In whole cell expression studies FXYD1 reduces the apparent affinity for Na ions. Possible reasons for the difference from this study using the purified recombinant Na,K-ATPase are discussed. ..

More Information

Publications200 found, 100 shown here

  1. Buschmann T, Zhang R, Brash D, Bystrykh L. Enhancing the detection of barcoded reads in high throughput DNA sequencing data by controlling the false discovery rate. BMC Bioinformatics. 2014;15:264 pubmed publisher
    ..Following an analysis of the data for sequence variants induced in the Atp1a1 gene of C57BL/6 murine melanocytes by ultraviolet light and conferring resistance to ouabain, we found no evidence ..
  2. Shematorova E, Shpakovski D, Chernysheva A, Shpakovski G. Molecular mechanisms of the juvenile form of Batten disease: important role of MAPK signaling pathways (ERK1/ERK2, JNK and p38) in pathogenesis of the malady. Biol Direct. 2018;13:19 pubmed publisher
    ..Particularly, CLN3 interacts with a subunit of Na/K ATPase ATP1A1 which changes its conformation and activates the adjacent epidermal growth factor receptor (EGFR)...
  3. Lan Y, Zou Y, Lou J, Xing J, Wang X, Zou S, et al. The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway. Cell Biol Toxicol. 2019;: pubmed publisher
    ..The critical roles of the sodium pump α1 subunit (ATP1A1) in mediating the XPO1-targeted anticancer effect of bufalin in human glioma were further confirmed...
  4. Backman S, Akerström T, Maharjan R, Cupisti K, Willenberg H, Hellman P, et al. RNA Sequencing Provides Novel Insights into the Transcriptome of Aldosterone Producing Adenomas. Sci Rep. 2019;9:6269 pubmed publisher
    ..Somatic mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D and CTNNB1 have been described in ~60% of these tumours...
  5. Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, et al. Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1. Mol Endocrinol. 2008;22:2609-23 pubmed publisher
    ..We here addressed this issue using atp1a1 and scnn1a, both of which are up-regulated in response to corticosteroids in human embryonic kidney-derived 293 ..
  6. Key J, Mueller A, Gispert S, Matschke L, Wittig I, Corti O, et al. Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol Dis. 2019;127:114-130 pubmed publisher
    ..for Hippocalcin (HPCA), Calmodulin (CALM1/CALML3), Pyruvate Kinase (PKM2), sodium/potassium-transporting ATPases (ATP1A1/2/3/4), the Rab27A-GTPase activating protein alpha (TBC1D10A) and an ubiquitin ligase adapter (DDB1), while strong ..
  7. Fernandes Rosa F, Williams T, Riester A, Steichen O, Beuschlein F, Boulkroun S, et al. Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension. 2014;64:354-61 pubmed publisher
    Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs)...
  8. Baumann O, Salvaterra P, Takeyasu K. Developmental changes in beta-subunit composition of Na,K-ATPase in the Drosophila eye. Cell Tissue Res. 2010;340:215-28 pubmed publisher
    ..The non-visual cells within the compound eye express almost exclusively Nrv2, which segregates together with the alpha-subunit to septate junctions throughout development. ..
  9. Madsen S, Weber C, Nielsen A, Mohiseni M, Bosssus M, Tipsmark C, et al. Sexual maturation and changes in water and salt transport components in the kidney and intestine of three-spined stickleback (Gasterosteus aculeatus L.). Comp Biochem Physiol A Mol Integr Physiol. 2015;188:107-19 pubmed publisher
    ..Salt-absorptive activity in the intestine may, however, be down-regulated during male maturation. ..
  10. Tain Y, Lin Y, Chan J, Lee C, Hsu C. Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light. Biol Reprod. 2017;97:636-643 pubmed publisher
    ..Maternal melatonin therapy prevented the increases of Slc9a3, Slc12a3, and Atp1a1 expression induced by maternal continuous light exposure...
  11. Abu Elsaad N, Abd Elhameed A, El Karef A, Ibrahim T. Yogurt Containing the Probacteria Lactobacillus acidophilus Combined with Natural Antioxidants Mitigates Doxorubicin-Induced Cardiomyopathy in Rats. J Med Food. 2015;18:950-9 pubmed publisher
    ..cholesterol, and tissue malondialdehyde (MDA) levels was observed in addition to an increase in serum Na(+)/K(+) ATP1A1 and cardiac reduced glutathione (GSH) levels...
  12. Chauhan N, Lee J, Siegel G. Na,K-ATPase mRNA levels and plaque load in Alzheimer's disease. J Mol Neurosci. 1997;9:151-66 pubmed
    ..3. The declines in alpha 3-mRNA per neuron found in normal aging may predispose to or potentiate AD pathogenesis. ..
  13. Kassardjian A, Kreydiyyeh S. JNK modulates the effect of caspases and NF-kappaB in the TNF-alpha-induced down-regulation of Na+/K+ATPase in HepG2 cells. J Cell Physiol. 2008;216:615-20 pubmed publisher
    ..Their activity was however modulated at 1 h by c-JNK, which stimulated the caspases and inhibited NF-kappaB, resulting in a net inhibition of the ATPase, and probably favoring the apoptotic pathway. ..
  14. Fuller W, Eaton P, Bell J, Shattock M. Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB J. 2004;18:197-9 pubmed
    ..The role of PLM is analogous to phospholamban in regulating the sarcoplasmic reticulum calcium ATPase. ..
  15. Floyd R, Wray S, Quenby S, Martín Vasallo P, Mobasheri A. Expression and distribution of Na, K-ATPase isoforms in the human uterus. Reprod Sci. 2010;17:366-76 pubmed publisher
    ..In pregnancy, there was a switch in isoform expression, resulting in increased beta3 and decreased FXYD2 at the protein and messenger RNA (mRNA) levels. Na, K-ATPase isoform alterations may modulate uterine contractility during labor. ..
  16. Suñol M, Cusi V, Cruz O, Kiss R, Lefranc F. Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas. Anticancer Res. 2011;31:953-8 pubmed
    ..Moreover, it should be determined whether inhibition of the α1/α3 NaK subunits can be integrated into the risk stratification schemes already in use for medulloblastoma patients. ..
  17. Azizan E, Poulsen H, Tuluc P, Zhou J, Clausen M, Lieb A, et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet. 2013;45:1055-60 pubmed publisher
    ..Gain-of-function mutations in KCNJ5 and apparent loss-of-function mutations in ATP1A1 and ATP2A3 were reported to occur in APAs...
  18. Chen X, Wee N, Hiong K, Ong J, Chng Y, Ching B, et al. Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance. PLoS ONE. 2013;8:e84298 pubmed publisher
    ..albus. ..
  19. Cherniavsky Lev M, Golani O, Karlish S, Garty H. Ouabain-induced internalization and lysosomal degradation of the Na+/K+-ATPase. J Biol Chem. 2014;289:1049-59 pubmed publisher
    ..This mechanism may be required due to the very slow dissociation of the ouabain·Na(+)/K(+)-ATPase complex. ..
  20. Ovchinnikov YuA -, Monastyrskaya G, Broude N, Allikmets R, Ushkaryov YuA -, Melkov A, et al. The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit. FEBS Lett. 1987;213:73-80 pubmed
  21. Wang J, Schwinger R, Frank K, Müller Ehmsen J, Martin Vasallo P, Pressley T, et al. Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart. J Clin Invest. 1996;98:1650-8 pubmed
  22. Damulewicz M, Rosato E, Pyza E. Circadian regulation of the Na+/K+-ATPase alpha subunit in the visual system is mediated by the pacemaker and by retina photoreceptors in Drosophila melanogaster. PLoS ONE. 2013;8:e73690 pubmed publisher
  23. Monticone S, Castellano I, Versace K, Lucatello B, Veglio F, Gomez Sanchez C, et al. Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas. Mol Cell Endocrinol. 2015;411:146-54 pubmed publisher
    ..Recently reported somatic mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D can partially account for these differences...
  24. Deng W, Wang D. [Effect of arginine vasopressin on alveolar fluid clearance in rats with acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:1602-5 pubmed
    ..296 ± 0.322 vs 0.349 ± 0.141) and α1-Na⁺, K⁺-ATPase (1.421 ± 0.389 vs 0.338 ± 0.186) (P<0.05). AVP can promote AFC in with ALI possibly by up-regulation of α-ENaC, α1-Na⁺, and K⁺-ATPase. ..
  25. Åkerström T, Maharjan R, Sven Willenberg H, Cupisti K, Ip J, Moser A, et al. Activating mutations in CTNNB1 in aldosterone producing adenomas. Sci Rep. 2016;6:19546 pubmed publisher
    ..1% of the tumors, occurring mutually exclusive from mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D...
  26. Zacherl S, La Venuta G, Muller H, Wegehingel S, Dimou E, Sehr P, et al. A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2. J Biol Chem. 2015;290:3654-65 pubmed publisher
    ..Based upon an unbiased RNAi screen, we now report the identification of ATP1A1, the α1-chain of the Na/K-ATPase, as a factor required for efficient secretion of FGF2...
  27. Sverdlov E, Monastyrskaya G, Broude N, Ushkaryov YuA -, Allikmets R, Melkov A, et al. The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. FEBS Lett. 1987;217:275-8 pubmed
    ..A comparative analysis of the primary structure of these genes in the region 749-1328 (in coordinates of cDNA from the pig alpha-subunit) is presented. ..
  28. Hosseini S, Asgari V, Ostadhosseini S, Hajian M, Ghanaei H, Nasr Esfahani M. Developmental competence of ovine oocytes after vitrification: differential effects of vitrification steps, embryo production methods, and parental origin of pronuclei. Theriogenology. 2015;83:366-76 pubmed publisher
    ..comparable mRNA abundances of CNX43, HSP90, GMNN, NPM, and OCT4 between vitrified and fresh oocytes, whereas CCNB, ATP1A1, and PAP transcripts were significantly lower in vitrified versus fresh oocytes...
  29. Nakajima Y, Okamura T, Horiguchi K, Gohko T, Miyamoto T, Satoh T, et al. GNAS mutations in adrenal aldosterone-producing adenomas. Endocr J. 2016;63:199-204 pubmed publisher
    ..Our results suggest that these mutations, in addition to mutations in the KCNJ5 gene and other genes such as ATP1A1, ATP2B3 and CACNA1D, may be responsible for the tumorigenesis of APAs and CPAs with subclinical Cushing's syndrome...
  30. Ferrandi M, Salardi S, Tripodi G, Barassi P, Rivera R, Manunta P, et al. Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension. Am J Physiol. 1999;277:H1338-49 pubmed
    ..Our findings strongly imply the existence of a direct and specific interaction between adducin and Na(+)-K(+)-ATPase in vitro and also suggest the possibility of such an interaction in intact renal membranes. ..
  31. Imagawa T, Kaya S, Taniguchi K. The amino acid sequence 442GDASE446 in Na/K-ATPase is an important motif in forming the high and low affinity ATP binding pockets. J Biol Chem. 2003;278:50283-92 pubmed
    ..These data and others indicate that the sequence 442GDASE446 in the ATP binding pocket is an important motif that it is involved in both the high and low affinity ATP effects rather than in free Mg2+, Na+, and K+ effects. ..
  32. Juel C, Nordsborg N, Bangsbo J. Purinergic effects on Na,K-ATPase activity differ in rat and human skeletal muscle. PLoS ONE. 2014;9:e91175 pubmed publisher
    ..Rat muscle is not a reliable model for purinergic effects on Na,K-ATPase in human skeletal muscle...
  33. Gomez Sanchez C, Kuppusamy M, Gomez Sanchez E. Somatic mutations of the ATP1A1 gene and aldosterone-producing adenomas. Mol Cell Endocrinol. 2015;408:213-9 pubmed publisher
    ..3, α1 subunit of the sodium potassium ATPase, and membrane calcium ATPase 3. This review concentrates on the molecular and physiological mechanisms by which mutations of the ATP1A1 gene increase aldosterone production.
  34. Fernandes Rosa F, Giscos Douriez I, Amar L, Gomez Sanchez C, Meatchi T, Boulkroun S, et al. Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma. Hypertension. 2015;66:1014-22 pubmed publisher
    Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D are found in aldosterone-producing adenoma...
  35. Dergousova E, Poluektov Y, Klimanova E, Petrushanko I, Mitkevich V, Makarov A, et al. Glutathionylation of Na,K-ATPase Alpha-Subunit Alters Enzyme Conformation and Sensitivity to Trypsinolysis. Biochemistry (Mosc). 2018;83:969-981 pubmed publisher
  36. Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W. Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells. Tissue Antigens. 2006;68:509-17 pubmed
    ..Furthermore, we showed the association of beta3 subunit and alpha subunit of Na, K ATPase. This information is important for further understanding of the functional roles of this molecule. ..
  37. Vereninov A, Rubashkin A, Goryachaya T, Moshkov A, Rozanov Y, Shirokova A, et al. Pump and channel K (Rb+) fluxes in apoptosis of human lymphoid cell line U937. Cell Physiol Biochem. 2008;22:187-94 pubmed publisher
    ..It is concluded that moderate apoptotic cell shrinkage may be associated with both an increase in K(+) channel permeability and inhibition of the pump whereas more remarkable shrinkage occurs presumably due to inhibition of the pump. ..
  38. Wang B, Li X, Zhang X, Ma X, Chen L, Zhang Y, et al. Prevalence and characterization of somatic mutations in Chinese aldosterone-producing adenoma patients. Medicine (Baltimore). 2015;94:e708 pubmed publisher
    Recently somatic mutations of KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been identified in patients with aldosterone-producing adenoma (APA)...
  39. Scholl U, Healy J, Thiel A, Fonseca A, Brown T, Kunstman J, et al. Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype. Clin Endocrinol (Oxf). 2015;83:779-89 pubmed publisher
    ..Somatic mutations in KCNJ5, CACNA1D, ATP1A1, ATP2B3 and CTNNB1 have been described in APAs...
  40. Dieho K, van Baal J, Kruijt L, Bannink A, Schonewille J, Carreno D, et al. Effect of supplemental concentrate during the dry period or early lactation on rumen epithelium gene and protein expression in dairy cattle during the transition period. J Dairy Sci. 2017;100:7227-7245 pubmed publisher
    ..A day and treatment interaction was observed for ATP1A1 in the dry period experiment, with greater expression at 18 and 8 d antepartum for concentrate than no concentrate...
  41. Aughey R, Murphy K, Clark S, Garnham A, Snow R, Cameron Smith D, et al. Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes. J Appl Physiol (1985). 2007;103:39-47 pubmed
    ..The Na+ -K+ -ATPase mRNA response to interval exercise of increased alpha- but not beta-mRNA was largely preserved posttrain, suggesting a functional role of alpha mRNA upregulation. ..
  42. Mathieu V, Pirker C, Martin de Lassalle E, Vernier M, Mijatovic T, DeNeve N, et al. The sodium pump alpha1 sub-unit: a disease progression-related target for metastatic melanoma treatment. J Cell Mol Med. 2009;13:3960-72 pubmed publisher
    ..UNBS1450 also displayed marked anti-tumour activity in the aggressive human metastatic brain melanoma model in vivo. The alpha1 sodium pump sub-unit could represent a potential novel target for combating melanoma. ..
  43. Stengelin M, Hoffman J. Na,K-ATPase subunit isoforms in human reticulocytes: evidence from reverse transcription-PCR for the presence of alpha1, alpha3, beta2, beta3, and gamma. Proc Natl Acad Sci U S A. 1997;94:5943-8 pubmed
    ..The extent to which the kinetic properties of uncoupled sodium efflux might depend on different isoform combinations is not yet known. ..
  44. Burkard C, Verheije M, Haagmans B, van Kuppeveld F, Rottier P, Bosch B, et al. ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. J Virol. 2015;89:4434-48 pubmed publisher
    ..In this study, we analyzed the role of Na(+),K(+)-ATPase and, in particular, of its ATP1A1 α subunit during coronavirus (CoV) infection...
  45. Scifo E, Szwajda A, Soliymani R, Pezzini F, Bianchi M, Dapkunas A, et al. Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015;123:42-53 pubmed publisher
    ..Moreover, the PPT1 IP implicate the enzyme in novel roles including: involvement in neuronal migration and dopamine receptor mediated signalling pathway. ..
  46. Wu I, Chen Y, Wu C, Cheng Y, Chen W, Ko H, et al. Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma. Oncotarget. 2016;7:85244-85258 pubmed publisher
    ..Among the paired cancer and adjacent normal tissues from 14 ESCC patients, 10 pairs (71.4%) had overexpression of ATP1A1 (ATPase Na+/K+ transporting alpha 1 polypeptide) by qPCR (P = 0.0052)...
  47. Lan Y, Wang X, Lou J, Xing J, Yu Z, Wang H, et al. Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase ?1 subunit. Biomed Pharmacother. 2018;103:204-215 pubmed publisher
    ..Currently, the ?1 subunit of Na+/K+-ATPase (ATP1A1) is known to exert important roles in tumorigenesis, and the precise mechanisms underlying the effect of Bufalin ..
  48. Johar K, Priya A, Wong Riley M. Regulation of Na(+)/K(+)-ATPase by nuclear respiratory factor 1: implication in the tight coupling of neuronal activity, energy generation, and energy consumption. J Biol Chem. 2012;287:40381-90 pubmed publisher
    ..mutational analysis, and real-time quantitative PCR, NRF-1 was found to functionally bind to the promoters of Atp1a1 and Atp1b1 genes but not of the Atp1a3 gene in neurons...
  49. El Zein R, Boulkroun S, Fernandes Rosa F, Zennaro M. Molecular genetics of Conn adenomas in the era of exome analysis. Presse Med. 2018;47:e151-e158 pubmed publisher
    ..Exome analysis of APA has allowed the identification of recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 in more than 50 % of sporadic cases...
  50. Takeyasu K, Lemas V, Fambrough D. Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution. Am J Physiol. 1990;259:C619-30 pubmed
    ..The implications of this conversation of isoform-specific structural features are discussed in terms of transport functions and bioregulation of the Na(+)-K(+)-ATPase...
  51. Sverdlov E, Broude N, Sverdlov V, Monastyrskaya G, Grishin A, Petrukhin K, et al. Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. FEBS Lett. 1987;221:129-33 pubmed
    ..In addition, the tissue specificity of the expression of different genes of the family of Na+,K+-ATPase genes and their low expression in tumor cells have been demonstrated. ..
  52. Rahman M, Tae H, Cho H, Shin G, Park B. Developmental expression analysis of Na, K-ATPase α subunits in Xenopus. Dev Genes Evol. 2015;225:105-11 pubmed publisher
    ..The Na, K-ATPase α1 (atp1a1), and atp1a3 share many expression domains in placode derivatives, including the otic vesicle, lens, ganglion of ..
  53. Wang H, Ji Y, Wu G, Sun K, Sun Y, Li W, et al. l-Tryptophan Activates Mammalian Target of Rapamycin and Enhances Expression of Tight Junction Proteins in Intestinal Porcine Epithelial Cells. J Nutr. 2015;145:1156-62 pubmed publisher
    ..family 6 member 14 (SLC6A14), solute carrier family 6 member 19 (SLC6A19), and Na(+)/K(+) ATPase subunit-α1 (ATP1A1)], abundance of proteins involved in mTOR signaling, and TJ proteins were determined...
  54. Nair B, Johar K, Priya A, Wong Riley M. Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons. Biochim Biophys Acta. 2016;1863:1-9 pubmed publisher
    ..It also regulates Atp1a1 and Atp1b1 subunit genes of Na(+)/K(+)-ATPase, a major energy-consuming enzyme, as well as all 13 subunits of ..
  55. Kitamoto T, Suematsu S, Yamazaki Y, Nakamura Y, Sasano H, Matsuzawa Y, et al. Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations. J Clin Endocrinol Metab. 2016;101:494-503 pubmed publisher
    ..Somatic ATPase and CACNA1D gene mutations were analyzed in 42 APA tissues without KCNJ5 gene mutations. ATP1A1, ATP2B3, and CACNA1D mutations were detected in one, four, and four patients, respectively...
  56. Dutta R, Welander J, Brauckhoff M, Walz M, Alesina P, Arnesen T, et al. Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas. Endocr Relat Cancer. 2014;21:L1-4 pubmed publisher
  57. Mavrogonatou E, Papadimitriou K, Urban J, Papadopoulos V, Kletsas D. Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells. J Cell Physiol. 2015;230:3037-48 pubmed publisher
    ..of >100 and >200 genes, respectively, including nine genes encoding transporters (SLC4A11, SLC5A3, ATP1A1, SLC38A2, KCNK17, KCTD20, KCTD11, SLC7A5, and CLCA2)...
  58. Fallo F, Castellano I, Gomez Sanchez C, Rhayem Y, Pilon C, Vicennati V, et al. Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series. Endocrine. 2017;58:503-512 pubmed publisher
    ..Spot regions for mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, PRKACA, and CTNNB1 gene sequences were evaluated...
  59. van Groen B, van de Steeg E, Mooij M, van Lipzig M, de Koning B, Verdijk R, et al. Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants. Eur J Pharm Sci. 2018;124:217-227 pubmed publisher
    ..Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3, NTCP, OCT1, OATP1B1, OATP1B3, OATP2B1 and ATP1A1 were quantified with LC-MS/MS in isolated crude membrane fractions of snap-frozen post-mortem fetal and pediatric, ..
  60. Lingrel J, Orlowski J, Shull M, Price E. Molecular genetics of Na,K-ATPase. Prog Nucleic Acid Res Mol Biol. 1990;38:37-89 pubmed
  61. Zicha J, Negrin C, Dobesova Z, Carr F, Vokurkova M, McBride M, et al. Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene. Physiol Genomics. 2001;6:99-104 pubmed
    A genetic variant of the gene for the alpha(1)-isoform of Na(+)-K(+)-ATPase (Atp1a1) was suggested to be involved in the pathogenesis of salt hypertension in Dahl rats through altered Na(+):K(+) coupling ratio...
  62. Yu M, Mu C, Yang Y, Zhang C, Su Y, Huang Z, et al. Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets. Amino Acids. 2017;49:1587-1599 pubmed publisher
    ..CAT1, EAAC1, ASCT2, y+LAT1), peptide transporters (PepT1), and Na+-K+-ATPase (ATP1A1), and ileal AA transporters (ASCT2, y+LAT1, b0,+AT, and B0AT1), and ATP1A1...
  63. Vlachos D, Schulpis K, Antsaklis A, Mesogitis S, Biliatis I, Tsakiris S. Erythrocyte membrane AChE, Na(+), K(+)-ATPase and Mg(2+) ATPase activities in mothers and their premature neonates in relation to the mode of delivery. Scand J Clin Lab Invest. 2010;70:568-74 pubmed publisher
    ..Mg(2+)-ATPase activity was unchanged. The increased maternal AChE and Na(+), K(+)-ATPase activities may be due to the low TAS determined post VD, whereas their decreased activities in prematures to their immaturity. ..
  64. Faguer S, Decramer S, Devuyst O, Lengelé J, Fournié G, Chauveau D. Expression of renal cystic genes in patients with HNF1B mutations. Nephron Clin Pract. 2012;120:c71-8 pubmed publisher
    ..target genes (PKHD1, PKD1, PKD2, IFT88, TMEM27 and UMOD) and three genes involved in the Mg(2+) renal homeostasis (ATP1A1, FXYD2 and CLDN16) in the urinary sediment of 11 individuals with mutation of HNF1B and in 9 controls (non-..
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    ..3 days, and examined changes in plasma components as well as gill and rectal gland Na(+)/K(+)-ATPase α1 (atp1a1) mRNA expression...
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    ..More recently, somatic mutations in CACNA1D, ATP1A1 and ATP2B3, also important for membrane potential/intracellular Ca(2) (+) regulation, were observed in APAs...
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    Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH)...
  68. Takase S, Kurokawa R, Arai D, Kanemoto Kanto K, Okino T, Nakao Y, et al. A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B. Sci Rep. 2017;7:2002 pubmed publisher
    ..An shRNA library screen with this system revealed that downregulation of ATP1A1, an α-subunit of Na+/K+ ATPase, conferred significant sensitivity to aurilide B, a natural ..
  69. Ji H, Kang N, Chen T, Lv L, Ma X, Wang F, et al. Shen-ling-bai-zhu-san, a spleen-tonifying Chinese herbal formula, alleviates lactose-induced chronic diarrhea in rats. J Ethnopharmacol. 2019;231:355-362 pubmed publisher
    ..including γ-epithelial sodium channel (ENAC-γ) and sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) in distal colon were detected by immunohistochemistry and western blotting...
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    ..We identified the ?1 subunit of Na+,K+-ATPase (ATP1a1) as a novel Rab27a interacting protein in melanocytes and showed that this interaction is direct with the ..
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    Recent studies have shown that somatic mutations in the KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes are associated with the pathogenesis of aldosterone-producing adenoma...
  73. Zhou J, Shaikh L, Neogi S, McFarlane I, Zhao W, Figg N, et al. DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion. Hypertension. 2015;65:1103-10 pubmed publisher
    Common somatic mutations in CACNAID and ATP1A1 may define a subgroup of smaller, zona glomerulosa (ZG)-like aldosterone-producing adenomas...
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    ..Gene expression of Na(+)/K(+) ATPase channel isoforms, Atp1a1, Atp1a3, and Atp1b1, displayed no significant differences...
  75. Feschenko M, Sweadner K. Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C. J Biol Chem. 1995;270:14072-7 pubmed
    ..It is also likely to be relevant to other known species-specific effects of protein kinase C on Na,K-ATPase. ..
  76. Feraille E, Carranza M, Gonin S, Beguin P, Pedemonte C, Rousselot M, et al. Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10. Mol Biol Cell. 1999;10:2847-59 pubmed
    ..These findings indicate that phosphorylation of the Na+,K(+)-ATPase alpha-subunit at Tyr-10 likely participates in the physiological control of sodium reabsorption in PCT. ..
  77. Wangemann P. K+ cycling and the endocochlear potential. Hear Res. 2002;165:1-9 pubmed
    ..the basolateral membrane of strial marginal cells via the Na+/2Cl-/K+ cotransporter SLC12A2 and the Na+/K+-ATPase ATP1A1/ATP1B2...
  78. Cairo E, Swarts H, Wilmer M, Willems P, Levtchenko E, De Pont J, et al. FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia?. J Membr Biol. 2009;231:117-24 pubmed publisher
    ..We conclude that human proximal tubular cells respond to a hyperosmotic challenge with an increase in FXYD2 and Na,K-ATPase protein expression, though to a smaller absolute extent in patient cells. ..
  79. Holthouser K, Mandal A, Merchant M, Schelling J, Delamere N, Valdes R, et al. Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells. Am J Physiol Renal Physiol. 2010;299:F77-90 pubmed publisher
    ..These results suggest that the association of NHE-1 with Na-K-ATPase is critical for ouabain-mediated regulation of Na-K-ATPase and that these effects may play a role in cardioglycoside-stimulated hypertension. ..
  80. Zennaro M, Boulkroun S, Fernandes Rosa F. An update on novel mechanisms of primary aldosteronism. J Endocrinol. 2015;224:R63-77 pubmed publisher
    ..Recurrent somatic mutations in genes coding for ion channels (KCNJ5 and CACNA1D) and ATPases (ATP1A1 and ATP2B3) regulating intracellular ionic homeostasis and cell membrane potential have been identified in APA...
  81. Faillot S, Assie G. ENDOCRINE TUMOURS: The genomics of adrenocortical tumors. Eur J Endocrinol. 2016;174:R249-65 pubmed publisher
    ..Exome sequencing identified new major drivers in all tumor types, including KCNJ5, ATP1A1, ATP2B3 and CACNA1D mutations in aldosterone-producing adenomas (APA), PRKACA mutations in cortisol-producing ..
  82. Harwood M, Achour B, Russell M, Carlson G, Warhurst G, Rostami Hodjegan A. Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique. J Pharm Biomed Anal. 2015;110:27-33 pubmed publisher
    ..concatenation (QconCAT) strategy to provide proteotypic peptide standards has been applied to quantify ATP1A1 (sodium/potassium-ATPase; Na/K-ATPase), CDH17 (human peptide transporter 1; HPT1), ABCB1 (P-glycoprotein; P-gp), ..
  83. Bossuyt J, Despa S, Han F, Hou Z, Robia S, Lingrel J, et al. Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem. 2009;284:26749-57 pubmed publisher
    ..1 +/- 1.1 mm, respectively) but increased V(max) only for NKA-alpha2 (1.9 +/- 0.4 versus 1.2 +/- 0.5 mm/min). In conclusion, PLM associates with and modulates both NKA-alpha1 and NKA-alpha2 in a comparable but not identical manner. ..
  84. Petrushanko I, Mitkevich V, Anashkina A, Adzhubei A, Burnysheva K, Lakunina V, et al. Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function. Sci Rep. 2016;6:27738 pubmed publisher
    ..Taken together, our data suggest the role of beta-amyloid as a novel physiological regulator of Na,K-ATPase. ..
  85. Dunbar L, Caplan M. Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases. J Biol Chem. 2001;276:29617-20 pubmed
    ..The molecular signals responsible for these properties have begun to be elucidated. It appears that a complex array of inter- and intramolecular interactions govern trafficking, distribution, and catalytic capacities of these proteins. ..
  86. Cheung J, Zhang X, Song J, Gao E, Chan T, Rabinowitz J, et al. Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). Adv Exp Med Biol. 2013;961:175-90 pubmed publisher
    ..PLM regulates important ion transporters in the heart and offers a tempting target for development of drugs to treat heart failure. ..
  87. Maniero C, Zhou J, Shaikh L, Azizan E, McFarlane I, Neogi S, et al. Role of ANO4 in regulation of aldosterone secretion in the zona glomerulosa of the human adrenal gland. Lancet. 2015;385 Suppl 1:S62 pubmed publisher
    ..A less common subtype of these adenomas, composed of cells resembling zona glomerulosa, have mutations in genes ATP1A1 and CACNA1D...
  88. Chen Y, Kennedy D, Ramakrishnan D, Yang M, Huang W, Li Z, et al. Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis. Sci Signal. 2015;8:ra91 pubmed publisher
    ..Using peritoneal macrophages isolated from Atp1a1 heterozygous or Cd36-null mice, we demonstrated that CD36 recruited an Na(+)/K(+)-ATPase-Lyn complex for Lyn ..
  89. Williams T, Peitzsch M, Dietz A, Dekkers T, Bidlingmaier M, Riester A, et al. Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas. Hypertension. 2016;67:139-45 pubmed publisher
    ..Somatic APA mutations have been described in other genes (CACNA1D, ATP1A1, and ATP2B3) albeit at a lower frequency...
  90. Saini C, Petrenko V, Pulimeno P, Giovannoni L, Berney T, Hebrok M, et al. A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells. Diabetes Obes Metab. 2016;18:355-65 pubmed publisher
    ..Among them, key regulators of the insulin secretion pathway (GNAQ, ATP1A1, ATP5G2, KCNJ11) and transcripts required for granule maturation and release (VAMP3, STX6, SLC30A8) were affected...