Gene Symbol: ATP11C
Description: ATPase phospholipid transporting 11C
Alias: ATPIG, ATPIQ, phospholipid-transporting ATPase IG, ATPase, class VI, type 11C, P4-ATPase flippase complex alpha subunit ATP11C
Species: human
Products:     ATP11C

Top Publications

  1. Liou A, Molday L, Wang J, Andersen J, Molday R. Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells. J Biol Chem. 2019;294:6809-6821 pubmed publisher
    ..Using affinity-based MS, we show that ATP11C is the only abundant P4-ATPase phospholipid flippase in human RBCs, whereas ATP11C and ATP8A1 are the major P4-..
  2. de Miguel F, Sharma R, Pajares M, Montuenga L, Rubio A, Pio R. Identification of alternative splicing events regulated by the oncogenic factor SRSF1 in lung cancer. Cancer Res. 2014;74:1105-15 pubmed publisher
    ..Moreover, the analysis allowed us to identify four genes, ATP11C, IQCB1, TUBD1, and proline-rich coiled-coil 2C (PRRC2C), with a significantly different pattern of alternative ..
  3. Segawa K, Yanagihashi Y, Yamada K, Suzuki C, Uchiyama Y, Nagata S. Phospholipid flippases enable precursor B cells to flee engulfment by macrophages. Proc Natl Acad Sci U S A. 2018;115:12212-12217 pubmed publisher
    ATP11A and ATP11C, members of the P4-ATPases, are flippases that translocate phosphatidylserine (PtdSer) from the outer to inner leaflet of the plasma membrane...
  4. Wang J, Molday L, Hii T, Coleman J, Wen T, Andersen J, et al. Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues. Sci Rep. 2018;8:10795 pubmed publisher
    ..Four P4-ATPases (ATP8A1, ATP11A, ATP11B, ATP11C) were present in all five tissues...
  5. Takatsu H, Tanaka G, Segawa K, Suzuki J, Nagata S, Nakayama K, et al. Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014;289:33543-56 pubmed publisher
    ..of plasma membrane-localized P4-ATPases using human cell lines stably expressing ATP8B1, ATP8B2, ATP11A, and ATP11C. We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine ..
  6. Naito T, Takatsu H, Miyano R, Takada N, Nakayama K, Shin H. Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics. J Biol Chem. 2015;290:15004-17 pubmed publisher
    We showed previously that ATP11A and ATP11C have flippase activity toward aminophospholipids (phosphatidylserine (PS) and phosphatidylethanolamine (PE)) and ATP8B1 and that ATP8B2 have flippase activity toward phosphatidylcholine (PC) (..
  7. Chaubey P, Hofstetter L, Roschitzki B, Stieger B. Proteomic Analysis of the Rat Canalicular Membrane Reveals Expression of a Complex System of P4-ATPases in Liver. PLoS ONE. 2016;11:e0158033 pubmed publisher
    ..ATP8A1 and ATP9A showed expression specific to the canalicular membrane, ATP11C at the bLPM and ATP11A in an intracellular vesicular compartment partially colocalizing with RAB7A and EEA1 as ..
  8. Naik J, de Waart D, Utsunomiya K, Duijst S, Mok K, Oude Elferink R, et al. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function. Dig Dis. 2015;33:314-8 pubmed publisher
    ..Recently it was shown that loss of the P4 ATPases ATP8B1 and ATP11C are associated with severe Cholestatic liver disease...
  9. Yabas M, Jing W, Shafik S, Bröer S, Enders A. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PLoS ONE. 2016;11:e0146774 pubmed publisher
    ..We demonstrate here that the P4-type ATPase ATP11C mediates significant flippase activity in all murine leukocyte subsets...

More Information


  1. Segawa K, Kurata S, Nagata S. The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane. J Biol Chem. 2018;293:2172-2182 pubmed publisher
    ..One mammalian phospholipid flippase at the plasma membrane is ATP11C, a type IV P-type ATPase (P4-ATPase) that forms a heterocomplex with the transmembrane protein CDC50A...
  2. Takada N, Takatsu H, Miyano R, Nakayama K, Shin H. ATP11C mutation is responsible for the defect in phosphatidylserine uptake in UPS-1 cells. J Lipid Res. 2015;56:2151-7 pubmed publisher
    ..We and others previously showed that ATP11C, a member of the P4-ATPases, translocates phosphatidylserine (PS) at the plasma membrane...
  3. Takatsu H, Takayama M, Naito T, Takada N, Tsumagari K, Ishihama Y, et al. Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation. Nat Commun. 2017;8:1423 pubmed publisher
    We and others showed that ATP11A and ATP11C, members of the P4-ATPase family, translocate phosphatidylserine (PS) and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflets at the plasma membrane...
  4. Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, et al. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. J Biol Chem. 2011;286:38159-67 pubmed publisher
    ..Here, we show that class 5 (ATP10A, ATP10B, and ATP10D) and class 6 (ATP11A, ATP11B, and ATP11C) P4-ATPases require CDC50 proteins, primarily CDC50A, for their exit from the endoplasmic reticulum (ER) and final ..
  5. Andrew Nesbit M, Bowl M, Harding B, Schlessinger D, Whyte M, Thakker R. X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. Genomics. 2004;84:1060-70 pubmed
    ..AS6 was identified as the 3' UTR of ATP11C, a novel member of the P-type ATPases, which consists of 31 exons with alternative transcripts...
  6. Arashiki N, Takakuwa Y, Mohandas N, Hale J, Yoshida K, Ogura H, et al. ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. Haematologica. 2016;101:559-65 pubmed publisher
    ..Herein, we report that ATP11C encodes a major flippase in human erythrocytes, and a genetic mutation identified in a male patient caused ..
  7. Liu L, Zhang L, Zhang L, Yang F, Zhu X, Lu Z, et al. Hepatic Tmem30a Deficiency Causes Intrahepatic Cholestasis by Impairing Expression and Localization of Bile Salt Transporters. Am J Pathol. 2017;187:2775-2787 pubmed publisher
    Mutations in ATP8B1 or ATP11C (members of P4-type ATPases) cause progressive familial intrahepatic cholestasis type 1 in human or intrahepatic cholestasis in mice...
  8. Paulusma C, Oude Elferink R. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Biochim Biophys Acta. 2005;1741:11-24 pubmed
  9. Segawa K, Kurata S, Nagata S. Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. J Biol Chem. 2016;291:762-72 pubmed publisher
    ..Mammalian ATP11C, a type IV P-type ATPase, acts as a flippase at the plasma membrane...
  10. Yokoi H, Hadano S, Kogi M, Kang X, Wakasa K, Ikeda J. Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection. Genomics. 1994;20:404-11 pubmed
    ..3-qter contained an open reading frame of 281 amino acids and was expressed in every tissue tested. This gene, as well as others isolated in this manner, may prove to be a candidate gene for heritable disorders mapping to this region. ..
  11. Segawa K, Kurata S, Yanagihashi Y, Brummelkamp T, Matsuda F, Nagata S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014;344:1164-8 pubmed publisher
    ..Using a haploid genetic screen in human cells, we found that ATP11C (adenosine triphosphatase type 11C) and CDC50A (cell division cycle protein 50A) are required for ..
  12. Matsuzaka Y, Hayashi H, Kusuhara H. Impaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice. Mol Pharmacol. 2015;88:1085-92 pubmed publisher
    ..We investigated the involvement of Atp11c in the hepatic transport of organic anions using Atp11c mutant mice, which exhibit hypercholanemia and ..
  13. Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
    ..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...