Gene Symbol: ATP11B
Description: ATPase phospholipid transporting 11B (putative)
Alias: ATPIF, ATPIR, ATPase IR, ATPase, class VI, type 11B, P4-ATPase flippase complex alpha subunit ATP11B, truncated ATPase 11B protein
Species: human
Products:     ATP11B

Top Publications

  1. Liou A, Molday L, Wang J, Andersen J, Molday R. Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells. J Biol Chem. 2019;294:6809-6821 pubmed publisher
    ..We also found that ATP11A and ATP11B are present at low levels...
  2. Lee P, Shin I, Seo S, Kim H, Kim H. Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP. Bioorg Med Chem Lett. 2014;24:4845-9 pubmed publisher
    Heme oxygenase-1 (HO-1) and ATPase inhibitory factor (ATPIF) 1 is often overexpressed in different types of cancer cells. Chrysin is a naturally-occurring flavonoid with antioxidant potentials, but also known to promote apoptosis...
  3. Isner J, Xu Z, Costa J, Monnet F, Batstone T, Ou X, et al. Actin filament reorganisation controlled by the SCAR/WAVE complex mediates stomatal response to darkness. New Phytol. 2017;215:1059-1067 pubmed publisher
    ..Stomata of an independent allele of the PIR gene (Atpir-1) showed reduced sensitivity to darkness and F1 progenies of the cross between opal5 and Atpir-1 ..
  4. Wang J, Molday L, Hii T, Coleman J, Wen T, Andersen J, et al. Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues. Sci Rep. 2018;8:10795 pubmed publisher
    ..Four P4-ATPases (ATP8A1, ATP11A, ATP11B, ATP11C) were present in all five tissues...
  5. Wang J, Wang Q, Zhou F, Wang D, Wen T. Silencing of ATP11B by RNAi-Induced Changes in Neural Stem Cell Morphology. Methods Mol Biol. 2017;1622:51-61 pubmed publisher
    ..This study describes effects of ATP11B on the morphology change of neural stem cells by using RNAi...
  6. Clark T, Schweitzer A, Chen T, Staples M, Lu G, Wang H, et al. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol. 2007;8:R64 pubmed
    ..In addition, we identified and validated a number of novel exons with tissue-specific splicing patterns. The tissue map data will likely serve as a valuable source of information on the regulation of alternative splicing. ..
  7. Hewetson A, Wright Pastusek A, Helmer R, Wesley K, Chilton B. Conservation of inter-protein binding sites in RUSH and RFBP, an ATP11B isoform. Mol Cell Endocrinol. 2008;292:79-86 pubmed publisher
    ..RUSH interact with a RING-finger binding protein (RFBP), which is a splice variant of the Type IV P-type ATPase, ATP11B. Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B are conserved in human and ..
  8. Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
    ..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...
  9. Halleck M, Schlegel R, Williamson P. Reanalysis of ATP11B, a type IV P-type ATPase. J Biol Chem. 2002;277:9736-40 pubmed publisher
    ..region containing transmembrane domain 4, corresponding to exon 12, is present in the human homolog of the gene, ATP11B. PCR analysis indicates that the predominant Atp11b transcripts in a rabbit cDNA library and in a mouse cDNA ..

More Information


  1. Paulusma C, Oude Elferink R. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Biochim Biophys Acta. 2005;1741:11-24 pubmed
  2. Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, et al. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. J Biol Chem. 2011;286:38159-67 pubmed publisher
    ..Here, we show that class 5 (ATP10A, ATP10B, and ATP10D) and class 6 (ATP11A, ATP11B, and ATP11C) P4-ATPases require CDC50 proteins, primarily CDC50A, for their exit from the endoplasmic reticulum (..
  3. Moreno Smith M, Halder J, Meltzer P, Gonda T, Mangala L, Rupaimoole R, et al. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest. 2013;123:2119-30 pubmed publisher
    ..Here, we report the discovery and characterization of the role of ATP11B, a P-type ATPase membrane protein, in cisplatin resistance...