ATOH1

Summary

Gene Symbol: ATOH1
Description: atonal bHLH transcription factor 1
Alias: ATH1, HATH1, MATH-1, bHLHa14, protein atonal homolog 1, atonal homolog 1, atonal homolog bHLH transcription factor 1, class A basic helix-loop-helix protein 14, helix-loop-helix protein hATH-1
Species: human
Products:     ATOH1

Top Publications

  1. Leonard J, Cook A, Van Gele M, Boyle G, Inglis K, Speleman F, et al. Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Int J Cancer. 2002;101:103-10 pubmed
    ..We demonstrate a correlation between Brn-3c and HATH1 reactivity in MCC biopsies and cell lines with retention of neuroendocrine phenotype...
  2. Kelly M, Chang Q, Pan A, Lin X, Chen P. Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo. J Neurosci. 2012;32:6699-710 pubmed publisher
    ..Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with which to promote hair cell regeneration...
  3. Benoit B, Bruno J, Kayal F, Estienne M, Debard C, Ducroc R, et al. Saturated and Unsaturated Fatty Acids Differently Modulate Colonic Goblet Cells In Vitro and in Rat Pups. J Nutr. 2015;145:1754-62 pubmed publisher
    ..All unsaturated LCFAs decreased the expression of human atonal homolog 1, a transcription factor controlling goblet cell differentiation (at least -31% vs. control)...
  4. Lewis R, Keller J, Wan L, Stone J. Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium. Hear Res. 2018;364:1-11 pubmed publisher
    ..cell destruction prevent supporting cells from upregulating expression of the pro-hair cell transcription factor ATOH1, entering the cell cycle, and fully transdifferentiating into hair cells, but they do not induce cell death...
  5. Kopecky B, Jahan I, Fritzsch B. Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability. Dev Dyn. 2013;242:132-47 pubmed publisher
    ..could be due to mis-regulation of genes necessary for neurosensory formation and maintenance, such as Neurod1, Atoh1, Pou4f3, and Barhl1...
  6. Yizhar Barnea O, Valensisi C, Jayavelu N, Kishore K, Andrus C, Koffler Brill T, et al. DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium. Sci Rep. 2018;8:17348 pubmed publisher
    ..regulatory networks around sites of differential methylation enabled us to link key inner ear regulators, such as Atoh1 and Stat3, to pathways responsible for cell lineage determination and maturation, such as the Notch pathway...
  7. Mandić A, Bennek E, Verdier J, Zhang K, Roubrocks S, Davis R, et al. c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine. Mucosal Immunol. 2017;10:1211-1223 pubmed publisher
    ..JNK2 additionally enhanced Atonal homolog 1 expression, goblet cell and enteroendocrine cell differentiation, and mucus production under inflammatory ..
  8. Shokouhi H, Farahmand B, Ghaemi A, Mazaheri V, Fotouhi F. Vaccination with three tandem repeats of M2 extracellular domain fused to Leismania major HSP70 protects mice against influenza A virus challenge. Virus Res. 2018;251:40-46 pubmed publisher
    ..immune responses revealed that the 3M2e-HSP70 chimer protein mainly stimulated IgG2a and IFN-? responses indicating aTh1 bias which shows the ability of HSP as a powerful adjuvant for activation of cellular immune responses...
  9. Nothwang H. Evolution of mammalian sound localization circuits: A developmental perspective. Prog Neurobiol. 2016;141:1-24 pubmed publisher
    ..This assumption is based on common embryonic origin from an Atoh1(+)/Wnt1(+) cell lineage in the rhombic lip of r5, same cell birth, a fusiform cell morphology, shared genetic ..

More Information

Publications118 found, 100 shown here

  1. Minich R, Li J, Tempel B. Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system. BMC Mol Biol. 2017;18:14 pubmed publisher
    ..This study identifies the proximal promoter of the αAtp2b2 transcript. Further investigations indicate that ATOH1 and EGR1 modulate promoter activity...
  2. Verhaegen M, Mangelberger D, Harms P, Eberl M, Wilbert D, Meireles J, et al. Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice. Cancer Res. 2017;77:3151-3157 pubmed publisher
    ..show that epidermis-targeted coexpression of sT and the cell fate-determinant atonal bHLH transcription factor 1 (ATOH1) leads to development of widespread cellular aggregates, with histology and marker expression mimicking that of ..
  3. Batts S, Shoemaker C, Raphael Y. Notch signaling and Hes labeling in the normal and drug-damaged organ of Corti. Hear Res. 2009;249:15-22 pubmed publisher
    ..The pro-sensory bHLH protein Atoh1 was absent at all time points following an ototoxic lesion, while the repressor bHLH transcription factors Hes1 ..
  4. Liu T, Zhu L, Zhang Z, Huang H, Zhang Z, Jiang L. Protective role of trehalose during radiation and heavy metal stress in Aureobasidium subglaciale F134. Sci Rep. 2017;7:17586 pubmed publisher
    ..Through the overexpression of the trehalose-6-phosphate synthase gene tps1 and the deletion of acid trehalase gene ath1, the APT?A double mutant exhibited a survival rate of 1% under 20?kGy of gamma-radiation, 2% survival rate at a UV ..
  5. Saxena A, Fayad R, Kaur K, Truman S, Greer J, Carson J, et al. Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. Cancer Biol Ther. 2017;18:257-267 pubmed publisher
    ..Our findings suggest that Se's protection against CICC involves both colonic epithelial protection and anti-tumor effects that are independent of APN. ..
  6. Mo P, Zhou Q, Guan L, Wang Y, Wang W, Miao M, et al. Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. Oncogene. 2015;34:3935-3945 pubmed publisher
    ..The mRNA levels of cyclin B1 and Hes5 were downregulated, but p27, ATOH1 and MUC2 were upregulated in the colon tumors from AIB1-deficient mice compared with those from wild-type mice...
  7. Palombo R, Porta G, Bruno E, Provero P, Serra V, Neduri K, et al. OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development. Aging (Albany NY). 2015;7:928-36 pubmed
    ..TAp63 positively regulates Hes5 and Atoh1 transcription...
  8. Lindemans C, Calafiore M, Mertelsmann A, O Connor M, Dudakov J, Jenq R, et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015;528:560-564 pubmed publisher
    ..b>ATOH1-deficient organoid culture demonstrated that IL-22 induced epithelial regeneration independently of the Paneth ..
  9. Schomann T, Mezzanotte L, de Groot J, Rivolta M, Hendriks S, Frijns J, et al. Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants. PLoS ONE. 2017;12:e0187183 pubmed publisher
    ..1 ?m/h. After arrival in the explant, the cells formed a fascicular pattern and changed their phenotype into an ATOH1-positive neuronal cell type...
  10. Lopez Juarez A, Lahlou H, Ripoll C, Cazals Y, Brezun J, Wang Q, et al. Engraftment of Human Stem Cell-Derived Otic Progenitors in the Damaged Cochlea. Mol Ther. 2019;: pubmed publisher
    ..We confirmed these results with hair cell progenitors derived from Atoh1-GFP mice as donor cells...
  11. Wölnerhanssen B, Moran A, Burdyga G, Meyer Gerspach A, Peterli R, Manz M, et al. Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals. Sci Rep. 2017;7:8174 pubmed publisher
    ..hormones, α-defensin, mucin 2, Na+/glucose co-transporter 1 (SGLT1) and transcription factors, Hes1, HATH1, NeuroD1, and Ngn3, were determined...
  12. Constantin L, Wainwright B. MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2. Cerebellum. 2015;14:688-98 pubmed publisher
    ..development, loxP-flanked exons of Dicer1 were conditionally inactivated using the granule cell precursor-specific Atoh1-Cre recombinase. A reduction of 87% in Dicer1 transcript was achieved in this conditional Dicer knockdown model...
  13. Willems P, Mhamdi A, Stael S, Storme V, Kerchev P, Noctor G, et al. The ROS Wheel: Refining ROS Transcriptional Footprints. Plant Physiol. 2016;171:1720-33 pubmed publisher
    ..Here, we reanalyzed a total of 79 Affymetrix ATH1 microarray studies of redox homeostasis perturbation experiments...
  14. Schwarzer S, Spieß S, Brand M, Hans S. Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biol Open. 2017;6:1270-1278 pubmed publisher
    ..in zebrafish, resembling the order of cell specification in amniotes; Neurog1 expression before Atoh1 expression...
  15. Iskusnykh I, Buddington R, Chizhikov V. Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia. Exp Neurol. 2018;306:209-221 pubmed publisher
    ..a reduced expression of Ccnd1 (Cyclin D1), Ccnb1 (Cyclin B1), granule cell master regulatory transcription factor Atoh1, and signaling molecule Jag1...
  16. Meyer R, Gryczka C, Neitsch C, Müller M, Bräutigam A, Schlereth A, et al. Genetic diversity for nitrogen use efficiency in Arabidopsis thaliana. Planta. 2019;: pubmed publisher
    ..Differential gene expression was determined using Affymetrix ATH1 arrays. We show that the response to differing nitrate availability is highly variable in Arabidopsis accessions...
  17. Badenes M, Trindade A, Pissarra H, Lopes da Costa L, Duarte A. Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms. BMC Cancer. 2017;17:50 pubmed publisher
    ..was associated to the observed increased epithelial differentiation deviated towards the secretory lineages by Atoh1 and Klf4 upregulation only in the ubiquitous Dll4 mutants...
  18. Secher J, Ceylan A, Mazzoni G, Mashayekhi K, Li T, Muenthaisong S, et al. Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells. Mol Reprod Dev. 2017;84:229-245 pubmed publisher
    ..A second striking difference was the expression of ATOH1 in piPSC-like cells, which was absent in the inner cell mass...
  19. Samarajeewa A, Jacques B, Dabdoub A. Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration. Mol Ther. 2019;: pubmed publisher
    ..Wnt and Notch pathways are critical for cochlear development; they converge on several key molecules, such as Atoh1, to regulate prosensory specification, proliferation, hair cell differentiation, and cellular organization...
  20. Cohen H, Amir R. Dose-dependent effects of higher methionine levels on the transcriptome and metabolome of transgenic Arabidopsis seeds. Plant Cell Rep. 2017;36:719-730 pubmed publisher
    ..To study the nature of these seeds, transcriptomic and primary metabolite profiling were employed using Affymetrix ATH1 microarray and gas chromatography-mass spectrometry analyses, respectively...
  21. Li S, Qian W, Jiang G, Ma Y. Transcription factors in the development of inner ear hair cells. Front Biosci (Landmark Ed). 2016;21:1118-25 pubmed
    ..Among these transcription factors, Math1, Gata3, Sox2 and Atoh1 have been highlighted for their crucial role in the fate of hair cells...
  22. Bucks S, Cox B, Vlosich B, Manning J, Nguyen T, Stone J. Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice. elife. 2017;6: pubmed publisher
    ..Type I hair cells are not restored by Plp1-CreERT2-expressing supporting cells or by Atoh1-CreERTM-expressing type II hair cells...
  23. Geng R, Omar A, Gopal S, Chen D, Stepanyan R, Basch M, et al. Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III. Sci Rep. 2017;7:13480 pubmed publisher
    ..TgAC1, consisting of Clrn1-UTR (Clrn1 cDNA including its 5' and 3' UTR) under the control of regulatory elements (Atoh1 3' enhancer/?-globin basal promoter) to direct expression of Clrn1 in hair cells during development and down ..
  24. Flasse L, Stern D, Pirson J, Manfroid I, Peers B, Voz M. The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine. Dev Biol. 2013;376:187-97 pubmed publisher
    ..Ascl1a as a key regulator of the secretory cell lineage in the zebrafish intestine, playing the same role as Atoh1 in the mouse intestine...
  25. Watson L, Wong M, Vowles J, Cowley S, Becker E. A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum. 2018;17:419-427 pubmed publisher
    ..of differentiation, subpopulations of cells representative of the two cerebellar germinal zones, the rhombic lip (Atoh1-positive) and ventricular zone (Ptf1a-positive), could be identified, with the latter giving rise to cells ..
  26. Hayashi Y, Kashiwagi M, Yasuda K, Ando R, Kanuka M, Sakai K, et al. Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice. Science. 2015;350:957-61 pubmed publisher
    ..origin with neurons promoting wakefulness; both derived from a pool of proneural hindbrain cells expressing Atoh1 at embryonic day 10.5...
  27. Wijayatunge R, Liu F, Shpargel K, Wayne N, Chan U, Boua J, et al. The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons. Mol Cell Neurosci. 2018;87:4-17 pubmed publisher
    ..b>Atoh1-Cre mediated conditional knockout of Kdm6b in CGN precursors either alone or in combination with Kdm6a did not ..
  28. Benito Gonzalez A, Doetzlhofer A. Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling. J Neurosci. 2014;34:12865-76 pubmed publisher
    ..the absence of Hey1 and Hey2 but differentiate prematurely because of precocious upregulation of the pro-HC factor Atoh1. Moreover, we demonstrate that prosensory-specific expression of Hey1 and Hey2 and its subsequent graded ..
  29. Jeong H, Choi J, Shin H, Bae J, Shin J. Seed-specific expression of seven Arabidopsis promoters. Gene. 2014;553:17-23 pubmed publisher
    ..To screen genes dominantly or specifically expressed in seed tissues, we analyzed Arabidopsis ATH1 microarray data open to the public...
  30. Nakanishi Y, Reina Campos M, Nakanishi N, Llado V, Elmén L, Peterson S, et al. Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι. Cell Rep. 2016;16:3297-3310 pubmed publisher
    ..Here, we show that PKCλ/ι is required for Paneth cell differentiation at the level of Atoh1 and Gfi1, through the control of EZH2 stability by direct phosphorylation...
  31. Vaillant C, Valdivieso P, Nuciforo S, Kool M, Schwarzentruber Schauerte A, Méreau H, et al. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PLoS ONE. 2015;10:e0124870 pubmed publisher
    ..In particular the transcription factor Atoh1, whose expression is essential for development of SHH subgroup medulloblastomas is lost...
  32. VanDussen K, Carulli A, Keeley T, Patel S, Puthoff B, Magness S, et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. 2012;139:488-97 pubmed publisher
    ..Analysis of Notch function in Atoh1-deficient intestine demonstrated that the cellular changes were dependent on Atoh1, whereas Notch regulation of ..
  33. Shi X, Wang Q, Gu J, Xuan Z, Wu J. SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development. Oncogene. 2016;35:5746-5758 pubmed publisher
    ..and binding experiments indicate that Brg1 specifically coordinates with key transcription factors including Gli1, Atoh1 and REST to regulate the expression of both oncogenes and tumor suppressors that are required for medulloblastoma ..
  34. Koehler K, Nie J, Longworth Mills E, Liu X, Lee J, Holt J, et al. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nat Biotechnol. 2017;35:583-589 pubmed publisher
    ..Additionally, using CRISPR-Cas9, we generate an ATOH1-2A-eGFP cell line to detect hair cell induction and demonstrate that derived hair cells exhibit ..
  35. Costa A, Sánchez Guardado L, Juniat S, Gale J, Daudet N, Henrique D. Generation of sensory hair cells by genetic programming with a combination of transcription factors. Development. 2015;142:1948-59 pubmed publisher
    ..Here, we show that combined expression of the transcription factors Gfi1, Pou4f3 and Atoh1 can induce direct programming towards HC fate, both during in vitro mouse embryonic stem cell differentiation and ..
  36. Zhang H, Pan H, Zhou C, Wei Y, Ying W, Li S, et al. Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing. Development. 2018;145: pubmed publisher
    ..Here, we first performed a proof-of-principle test by disrupting Atoh1, a gene crucial for auditory hair cell generation...
  37. Li W, You D, Chen Y, Chai R, Li H. Regeneration of hair cells in the mammalian vestibular system. Front Med. 2016;10:143-51 pubmed publisher
    ..and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch and Atoh1. This article provides an overview of the recent advances in hair cell regeneration in mammalian vestibular ..
  38. Karmakar K, Narita Y, Fadok J, Ducret S, Loche A, Kitazawa T, et al. Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem. Cell Rep. 2017;18:185-197 pubmed publisher
    ..We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input topography and sound ..
  39. Perdigoto C, Bardot E, Valdes V, Santoriello F, Ezhkova E. Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network. Development. 2014;141:4690-6 pubmed publisher
    ..We uncovered key transcription factors controlling this process and showed that the transcription factor Atoh1 is required for initial Merkel cell specification...
  40. Atkinson P, Dong Y, Gu S, Liu W, Najarro E, Udagawa T, et al. Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea. J Clin Invest. 2018;128:1641-1656 pubmed publisher
    ..Sox2haplo amplified and expanded domains of damage-induced Atoh1+ transitional cell formation in neonatal cochlea...
  41. Guillemot F, Hassan B. Beyond proneural: emerging functions and regulations of proneural proteins. Curr Opin Neurobiol. 2017;42:93-101 pubmed publisher
    Proneural proteins, which include Ascl1, Atoh1 and Neurogenins épinière in vertebrates and Achaete-Scute proteins and Atonal in Drosophila, are expressed in the developing nervous system throughout the animal kingdom and have an ..
  42. Waqas M, Zhang S, He Z, Tang M, Chai R. Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea. Front Med. 2016;10:237-49 pubmed publisher
    ..and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
  43. Wang J, Wu Y, Zhao F, Wu Y, Dong W, Zhao J, et al. Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish. J Neurosci. 2015;35:234-44 pubmed publisher
    ..Our work reveals that a genetic network of the previously known sensory determinant Atoh1 and the neural crest determinant Sox9 plays critical roles in SAG development...
  44. Riddiford N, Schlosser G. Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. elife. 2016;5: pubmed publisher
    ..g. Sox2, Hes8) and neuronal/sensory differentiation (e.g. Ngn1, Atoh1, Pou4f1, Gfi1) require Six1 and Eya1 for their placodal expression...
  45. Avenarius M, Krey J, Dumont R, Morgan C, Benson C, Vijayakumar S, et al. Heterodimeric capping protein is required for stereocilia length and width regulation. J Cell Biol. 2017;216:3861-3881 pubmed publisher
    ..We deleted Capzb specifically in hair cells using Atoh1-Cre, which eliminated auditory and vestibular function...
  46. Herring C, Banerjee A, McKinley E, Simmons A, Ping J, Roland J, et al. Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut. Cell Syst. 2018;6:37-51.e9 pubmed publisher
    ..We clarify that tuft cells are specified outside of the Atoh1-dependent secretory lineage in the small intestine...
  47. Men Y, Zhang A, Li H, Jin Y, Sun X, Li H, et al. LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration. Sci Rep. 2015;5:16232 pubmed publisher
    ..We created LKB1 conditional knockout mice (LKB1(Atoh1) CKO) to investigate the function of LKB1 in cerebellar development...
  48. Luo W, Ma R, Cheng X, Yang X, Han Z, Ren D, et al. Afferent synaptogenesis between ectopic hair-cell-like cells and neurites of spiral ganglion induced by Atoh1 in mammals in vitro. Neuroscience. 2017;357:185-196 pubmed publisher
    Newly formed ectopic hair-cell-like cells (EHCLCs) induced by overexpression of atonal homolog 1 (Atoh1) in vitro were found to possess features of endogenous hair cells (HCs) in previous reports and in the present study...
  49. Jahan I, Pan N, Kersigo J, Calisto L, Morris K, Kopecky B, et al. Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. PLoS ONE. 2012;7:e30853 pubmed publisher
    In the mammalian inner ear neurosensory cell fate depends on three closely related transcription factors, Atoh1 for hair cells and Neurog1 and Neurod1 for neurons...
  50. Tan X, Jahan I, Xu Y, Stock S, Kwan C, Soriano C, et al. Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation. Sci Rep. 2018;8:388 pubmed publisher
    ..direct interaction with spiral ganglion neurons (SGNs), we tested three genetically modified deaf mouse models: Atoh1-cre; Atoh1 f/f (Atoh1 conditional knockout, CKO), Atoh1-cre; Atoh1 f/kiNeurog1 (Neurog1 ..
  51. Fritzsch B, Jahan I, Pan N, Kersigo J, Duncan J, Kopecky B. Dissecting the molecular basis of organ of Corti development: Where are we now?. Hear Res. 2011;276:16-26 pubmed publisher
    ..However, Atoh1 null mutants have only undifferentiated and dying organ of Corti precursors but show a near normal extension of ..
  52. Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, et al. Reduced Human ?-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm Bowel Dis. 2016;22:1119-28 pubmed publisher
    ..HD6 expression was induced by the transfection of an atonal homolog 1 (Atoh1) transgene and was assessed by reverse transcription polymerase chain reaction...
  53. Puligilla C, Kelley M. Dual role for Sox2 in specification of sensory competence and regulation of Atoh1 function. Dev Neurobiol. 2017;77:3-13 pubmed publisher
    ..However, studies in which the HC determination factor Atoh1 was ectopically expressed in nonprosensory regions indicated that expression of Atoh1 alone is sufficient to ..
  54. Liu H, Li Y, Chen L, Zhang Q, Pan N, Nichols D, et al. Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?. PLoS ONE. 2016;11:e0168953 pubmed publisher
    ..We questioned whether hair cells and the stria interdepend for survival by using two mouse models. Atoh1 conditional knockout mice, which lose all hair cells within four weeks after birth, were used to determine whether ..
  55. Kuo B, Baldwin E, Layman W, Taketo M, Zuo J. In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1. J Neurosci. 2015;35:10786-98 pubmed publisher
    ..expression of a constitutively active form of β-catenin (a canonical Wnt activator) with ectopic expression of Atoh1 (a HC fate determination factor) in neonatal Lgr5+ cells (the presumed SC and HC progenitors of the postnatal ..
  56. Khan M, Ragni L, Tabb P, Salasini B, Chatfield S, Datla R, et al. Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis. Plant Physiol. 2015;169:2166-86 pubmed publisher
    ..BOP1/2) and KNOTTED-LIKE FROM ARABIDOPSIS THALIANA6 (KNAT6) together with ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1). Inactivation of genes in this module fully rescues pny pnf defects...
  57. Ostrowski S, Wright M, Bolock A, Geng X, Maricich S. Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis. Development. 2015;142:2533-44 pubmed publisher
    ..cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to ..
  58. Owa T, Taya S, Miyashita S, Yamashita M, Adachi T, Yamada K, et al. Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation. J Neurosci. 2018;38:1277-1294 pubmed publisher
    ..In the conditional KO (cKO) cerebella, many Atoh1-positive GCPs were observed ectopically in the inner external granule layer (EGL) and a similar phenomenon was ..
  59. Huang H, Zhai X, Zhu H, Wang W, Zhang S, Wu L, et al. Upregulation of Atoh1 correlates with favorable survival in gastrointestinal stromal tumor. Int J Clin Exp Pathol. 2014;7:7123-30 pubmed
    b>Atonal homolog 1 (Atoh1) is crucial to the differentiation of many cell types and participates in tumorigenesis and progression...
  60. Han M, Baek S, Kim S, Kang C, Oh S. ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells. PLoS ONE. 2015;10:e0126085 pubmed publisher
    ..Here we show that ATOH1 can induce the differentiation of gastric cancer stem cells (GCSCs)...
  61. Zak M, van Oort T, Hendriksen F, Garcia M, Vassart G, Grolman W. LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci. 2016;10:186 pubmed publisher
    ..positively regulates the proliferation of precursors and promotes the formation of hair cells by up-regulating Atoh1 expression. Not much, however, is known about the regulation of Wnt/?-catenin activity in the cochlea...
  62. Gonzalez L, Keller K, Chan K, Gessel M, Thines B. Transcriptome analysis uncovers Arabidopsis F-BOX STRESS INDUCED 1 as a regulator of jasmonic acid and abscisic acid stress gene expression. BMC Genomics. 2017;18:533 pubmed publisher
    ..Using publically available Affymetrix ATH1 microarray data, we show that FBS1 is significantly co-expressed in abiotic stresses with other well-characterized ..
  63. Leow C, Polakis P, Gao W. A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. Ann N Y Acad Sci. 2005;1059:174-83 pubmed
    ..Examination of Hath1, the human orthologue of Math1, expression in multiple colon tumor samples and colon cancer cell lines reveals a ..
  64. Maricich S, Xia A, Mathes E, Wang V, Oghalai J, Fritzsch B, et al. Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei. J Neurosci. 2009;29:11123-33 pubmed publisher
    b>Atoh1 is a basic helix-loop-helix transcription factor necessary for the specification of inner ear hair cells and central auditory system neurons derived from the rhombic lip...
  65. Liu Z, Dearman J, Cox B, Walters B, Zhang L, Ayrault O, et al. Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression. J Neurosci. 2012;32:6600-10 pubmed publisher
    ..of two SC subtypes, pillar cells (PCs) and Deiters' cells (DCs), into HCs by inducing targeted expression of Atoh1 at neonatal and juvenile ages using novel mouse models...
  66. Groves A, Zhang K, Fekete D. The genetics of hair cell development and regeneration. Annu Rev Neurosci. 2013;36:361-81 pubmed publisher
    ..that initiate hair cell development in vertebrates, with particular emphasis on the transcription factor Atoh1, which is both necessary and sufficient for hair cell development...
  67. Brown N, Dagenais S, Chen C, Glaser T. Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. Mamm Genome. 2002;13:95-101 pubmed
    ..A direct comparison of ATH5/7 and ATH1 protein subgroups to Atonal also revealed a nonrandom distribution of amino acid changes across the bHLH domain, ..
  68. Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M. Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Gastroenterology. 2007;132:208-20 pubmed
    The transcription factor Hath1 plays a crucial role in the differentiation program of the human gut epithelium...
  69. Westerman B, Breuer R, Poutsma A, Chhatta A, Noorduyn L, Koolen M, et al. Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. Int J Biol Markers. 2007;22:114-23 pubmed
    ..Out of 13 bHLH genes tested, 4 genes, i.e., achaete-scute complex-like 1 (ASCL1, HASH1, Mash1), atonal homolog 1 (ATOH1, HATH1, MATH1), NEUROD4 (ATH-3, Atoh3, MATH-3) and neurogenic differentiation factor 1 (NEUROD1, ..
  70. Kazanjian A, Noah T, Brown D, Burkart J, Shroyer N. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology. 2010;139:918-28, 928.e1-6 pubmed publisher
    The atonal homolog 1 (Atoh1) transcription factor is required for intestinal secretory (goblet, Paneth, enteroendocrine) cell differentiation...
  71. Xu H, Xie X, Li Q, Liu S, Dai S, Liu Y, et al. Atonal homolog 1 expression in lung cancer correlates with inhibitors of the Wnt pathway as well as the differentiation and primary tumor stage. APMIS. 2013;121:111-9 pubmed publisher
    b>Atonal homolog 1 (Atoh1) is crucial to the differentiation of many cell types and participates in tumorigenesis and progression...
  72. Chen Y, Yu H, Zhang Y, Li W, Lu N, Ni W, et al. Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult. Sci Rep. 2013;3:2996 pubmed publisher
    ..The results also suggest that inducing proliferating cells rather than quiescent cells to differentiate into hair cells by forced expression of Math1 is feasible for mammalian hair cell regeneration. ..
  73. Ying Z, Li X, Dang H, Wang F, Xu X. Effect of Hath1 on the proliferation and apoptosis of cutaneous squamous cell carcinoma in vitro. Mol Med Rep. 2015;12:7845-50 pubmed publisher
    Increasing evidence has demonstrated that the tumor suppressor gene Hath1 is implicated in the development and progression of tumors and is verified to be downregulated in several types of tumor...
  74. Xie W, Jen H, Seymour M, Yeh S, Pereira F, Groves A, et al. An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017;37:8583-8594 pubmed publisher
    b>Atonal homolog 1 (Atoh1) is a basic helix-loop-helix (bHLH) transcription factor that is essential for the genesis, survival, and maturation of a variety of neuronal and non-neuronal cell populations, including those involved in ..
  75. Du X, Jensen P, Goldowitz D, Hamre K. Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice. Dev Biol. 2007;305:430-8 pubmed
    ..The implication is that the lack of the Math1 gene in HC precursors can be overcome by environmental influences, such as cell-cell interactions with wild-type cells, to ultimately result in the formation of HCs. ..
  76. Kong J, Crissey M, Sepulveda A, Lynch J. Math1/Atoh1 contributes to intestinalization of esophageal keratinocytes by inducing the expression of Muc2 and Keratin-20. Dig Dis Sci. 2012;57:845-57 pubmed publisher
    ..To explore the contribution of Math1/Atoh1 to induction of Barrett's esophagus and intestinal mucin-secreting goblet cells from normal human esophageal ..
  77. Ikeda R, Pak K, Chavez E, Ryan A. Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells. Mol Neurobiol. 2015;51:672-84 pubmed
    Overexpression of the transcription factor (TF) ATOH1 is known to induce the transformation of nonsensory cells in the organ of Corti into hair cells (HCs)...
  78. Fukushima K, Tsuchiya K, Kano Y, Horita N, Hibiya S, Hayashi R, et al. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 2015;106:1000-7 pubmed publisher
    ..We have previously reported that the proteasomal degradation of the transcription factor Atonal homolog 1 (Atoh1) protein results in the non-mucinous form of CRC...
  79. Stojanova Z, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2015;142:3529-36 pubmed publisher
    ..cochlea, sensory hair cell differentiation depends on the regulated expression of the bHLH transcription factor Atoh1. In mammals, if hair cells die they do not regenerate, leading to permanent deafness...
  80. Zhou Y, Qing J, Dong Y, Nie J, Li J, Wang C, et al. The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation. Acta Otolaryngol. 2016;136:277-82 pubmed publisher
    Previous studies have stated the roles and correlation of the four TFs (Sox2, Atoh1, Neurog1, and Neurod1) in the development of neurosensory cells...
  81. da Cunha A, Antoniazi Michelin M, Candido Murta E. Phenotypic profile of dendritic and T cells in the lymph node of Balb/C mice with breast cancer submitted to dendritic cells immunotherapy. Immunol Lett. 2016;177:25-37 pubmed publisher
    ..Facts that led to aTh1 profile polarization, immuno competent in relation to breast cancer...
  82. Grausam K, Dooyema S, Bihannic L, Premathilake H, Morrissy A, Forget A, et al. ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. Cancer Res. 2017;77:3766-3777 pubmed publisher
    ..the relationship of tumor pathophysiology and dysregulated expression of the NOTCH pathway transcription factor ATOH1, which is present in aggressive medulloblastoma subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) ..
  83. Schmidt R, Boudichevskaia A, Cao H, He S, Meyer R, Reif J. Extracting genotype information of Arabidopsis thaliana recombinant inbred lines from transcript profiles established with high-density oligonucleotide arrays. Plant Cell Rep. 2017;36:1871-1881 pubmed publisher
    ..The sequences of the probes of the ATH1 GeneChip® exactly match transcript sequences of the Arabidopsis thaliana reference genome Col-0, ..
  84. Zhang T, Xu J, Maire P, Xu P. Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium. PLoS Genet. 2017;13:e1006967 pubmed publisher
    ..studies have suggested that downregulation of Sox2 expression in differentiating hair cells must occur after Atoh1 mRNA activation in order to allow Atoh1 protein accumulation due to antagonistic effects between Atoh1 and Sox2...
  85. Klisch T, Vainshtein A, Patel A, Zoghbi H. Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth. elife. 2017;6: pubmed publisher
    ..We have shown that the transcription factor Atonal homologue 1 (Atoh1) is required for Shh-type medulloblastoma development in mice...
  86. Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, et al. Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. Stem Cell Reports. 2018;10:27-42 pubmed publisher
    b>ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal epithelial cells (IECs)...
  87. Ben Arie N, McCall A, Berkman S, Eichele G, Bellen H, Zoghbi H. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Hum Mol Genet. 1996;5:1207-16 pubmed
    ..The mouse homolog (Math1) maps to mouse chromosome 6, and the human homolog (HATH1) to human chromosome 4q22...
  88. Gazit R, Krizhanovsky V, Ben Arie N. Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development. 2004;131:903-13 pubmed
    ..Taken together, our data demonstrate that CGC differentiation, but not specification, depends on Math1, which acts by regulating the level of multiple components of the Notch signaling pathway. ..
  89. Mutoh H, Sakamoto H, Hayakawa H, Arao Y, Satoh K, Nokubi M, et al. The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. Differentiation. 2006;74:313-21 pubmed
    ..Based on these results, we hypothesize that Cdx2 is involved in activating Math1 expression in intestinal epithelial cells. ..
  90. Bossuyt W, Kazanjian A, De Geest N, Van Kelst S, De Hertogh G, Geboes K, et al. Atonal homolog 1 is a tumor suppressor gene. PLoS Biol. 2009;7:e39 pubmed publisher
    ..Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural ..
  91. Heiskala K, Arola J, Heiskala M, Andersson L. Expression of Reg IV and Hath1 in neuroendocrine neoplasms. Histol Histopathol. 2010;25:63-72 pubmed publisher
    ..The helix-loop-helix transcription factor Hath1 is the human homologue of murine Math1, which regulates the embryonic differentiation of neural and intestinal ..
  92. Mulvaney J, Dabdoub A. Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency. J Assoc Res Otolaryngol. 2012;13:281-93 pubmed publisher
    b>Atoh1 (also known as Math1, Hath1, and Cath1 in mouse, human, and chicken, respectively) is a proneural basic helix-loop-helix (bHLH) transcription factor that is required in a variety of developmental contexts...