ATM

Summary

Gene Symbol: ATM
Description: ATM serine/threonine kinase
Alias: AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, serine-protein kinase ATM, A-T mutated, AT mutated, TEL1, telomere maintenance 1, homolog, ataxia telangiectasia mutated
Species: human
Products:     ATM

Top Publications

  1. Khoronenkova S, Dianova I, Ternette N, Kessler B, Parsons J, Dianov G. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell. 2012;45:801-13 pubmed publisher
    ..After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation ..
  2. Ouillette P, Li J, Shaknovich R, Li Y, Melnick A, Shedden K, et al. Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2012;51:1125-32 pubmed publisher
    A subset of chronic lymphocytic leukemia (CLL) carries mutations in ataxia telangiectasia mutated (ATM). Such ATM mutations may be particularly relevant in the setting of del11q, which invariably results in the deletion of one ATM allele...
  3. Jacquemin V, Rieunier G, Jacob S, Bellanger D, d Enghien C, Lauge A, et al. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. Eur J Hum Genet. 2012;20:305-12 pubmed publisher
    ..A-T is caused by biallelic inactivation of the ATM gene, in most cases by frameshift or nonsense mutations...
  4. Knappskog S, Chrisanthar R, Løkkevik E, Anker G, Østenstad B, Lundgren S, et al. Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer. Breast Cancer Res. 2012;14:R47 pubmed
    ..ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and Chk2 in response to genotoxic stress...
  5. Wang H, Shi L, Wong C, Han X, Hwang P, Truong L, et al. The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet. 2013;9:e1003277 pubmed publisher
    ..We further showed that these CDK-dependent phosphorylation events are a prerequisite for ATM to phosphorylate CtIP upon DNA damage, which is important for end resection to activate HR by promoting recruitment ..
  6. Navrkalova V, Sebejova L, Zemanova J, Kminkova J, Kubesova B, Malcikova J, et al. ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin. Haematologica. 2013;98:1124-31 pubmed publisher
    b>ATM abnormalities are frequent in chronic lymphocytic leukemia and represent an important prognostic factor. Sole 11q deletion does not result in ATM inactivation by contrast to biallelic defects involving mutations...
  7. Wu Z, Wong E, Shi Y, Niu J, Chen Z, Miyamoto S, et al. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell. 2010;40:75-86 pubmed publisher
    ..This response is mediated by a conserved pathway involving the nuclear ATM kinase and cytoplasmic I?B kinase (IKK); however, the molecular link between them remains incompletely understood...
  8. Segal Raz H, Mass G, Baranes Bachar K, Lerenthal Y, Wang S, Chung Y, et al. ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. EMBO Rep. 2011;12:713-9 pubmed publisher
    ..in DNA is a complex signalling network, mobilized by the nuclear protein kinase ataxia-telangiectasia mutated (ATM), which phosphorylates many factors in the various branches of this network...
  9. Talukder K, Azmi I, Ahmed K, Hossain M, Kabir Y, Cravioto A, et al. Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells. Microb Pathog. 2012;52:311-7 pubmed publisher
    ..It was also found that STX-1-induced p53 expression, and activated ATM in mammalian cells...

More Information

Publications73

  1. Xu L, Morari E, Wei Q, Sturgis E, Ward L. Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2012;97:1913-21 pubmed publisher
    b>ATM is critical in response to ionizing radiation-induced DNA damage. Variations in ATM are hypothesized to affect individual susceptibility to thyroid cancer...
  2. Mazumder Indra D, Mitra S, Roy A, Mondal R, Basu P, Roychoudhury S, et al. Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated with the development of invasive cervical carcinoma. Hum Genet. 2011;130:735-48 pubmed publisher
    ..the development of cervical cancer, we have studied the genetic and epigenetic alterations of the candidate genes ATM, PPP2R1B, SDHD and CADM1 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CACX) samples...
  3. Sabatel H, Di Valentin E, Gloire G, Dequiedt F, Piette J, Habraken Y. Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-?B-dependent transcription of specific genes after genotoxic stress. PLoS ONE. 2012;7:e38246 pubmed publisher
    ..It is activated by many external stimuli including genotoxic stress. DNA double-strand breaks activate NF-?B in an ATM-dependent manner...
  4. Gamper A, Choi S, Matsumoto Y, Banerjee D, Tomkinson A, Bakkenist C. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. J Biol Chem. 2012;287:12445-54 pubmed publisher
    ..with a characteristic hypersensitivity to ionizing radiation that is caused by biallelic mutations in A-T mutated (ATM), a gene encoding a protein kinase critical for the induction of cellular responses to DNA damage, particularly to ..
  5. Rose Zerilli M, Forster J, Parker H, Parker A, Rodríguez A, Chaplin T, et al. ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial. Haematologica. 2014;99:736-42 pubmed publisher
    b>ATM mutation and BIRC3 deletion and/or mutation have independently been shown to have prognostic significance in chronic lymphocytic leukemia...
  6. Golding S, Rosenberg E, Adams B, Wignarajah S, Beckta J, O Connor M, et al. Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control. Cell Cycle. 2012;11:1167-73 pubmed publisher
    ..Therefore, new treatment strategies are urgently needed. ATM elicits the DNA damage response (DDR), which confers cellular radioresistance; thus, targeting the DDR with an ATM ..
  7. Hinz M, Stilmann M, Arslan S, Khanna K, Dittmar G, Scheidereit C. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-?B activation. Mol Cell. 2010;40:63-74 pubmed publisher
    ..The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia telangiectasia mutated (ATM) act as proximal signal mediators...
  8. Taneichi D, Iijima K, Doi A, Koyama T, Minemoto Y, Tokunaga K, et al. Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 1. J Neuroimmune Pharmacol. 2011;6:177-87 pubmed publisher
    ..Consistently, Vpr-induced DSBs were attenuated by extensive downregulaion of endogenous SNF2h. Based on these data, we discuss the role of DSB and DSB signals in the viral infection. ..
  9. Choi S, Srivas R, Fu K, Hood B, Dost B, Gibson G, et al. Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes. J Proteome Res. 2012;11:4983-91 pubmed publisher
    b>ATM is a protein kinase that initiates a well-characterized signaling cascade in cells exposed to ionizing radiation (IR)...
  10. Wang Y, Yu Y, Tsuyada A, Ren X, Wu X, Stubblefield K, et al. Transforming growth factor-? regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene. 2011;30:1470-80 pubmed publisher
    ..b>Ataxia telangiectasia mutated (ATM), a target gene of miR-181, exhibited reduced expression in mammospheres and upon TGF-? treatment...
  11. Zhou K, Bellenguez C, Spencer C, Bennett A, Coleman R, Tavendale R, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011;43:117-20 pubmed publisher
    ..9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-1.49) at a locus containing ATM, the ataxia telangiectasia mutated gene...
  12. Verhagen M, Last J, Hogervorst F, Smeets D, Roeleveld N, Verheijen F, et al. Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study. Hum Mutat. 2012;33:561-71 pubmed publisher
    ..disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene...
  13. Lee A, Chiba T, Truong L, Cheng A, Do J, Cho M, et al. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem. 2012;287:2531-43 pubmed publisher
    ..We demonstrated that ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) proteins directly phosphorylate Dbf4 in ..
  14. Li J, Hart R, Mallimo E, Swerdel M, Kusnecov A, Herrup K. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci. 2013;16:1745-53 pubmed publisher
    The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency...
  15. Zhou Y, Paull T. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem. 2013;288:37112-25 pubmed publisher
    ..This work suggests that, in addition to its key role in nonhomologous end joining, DNA-PKcs also acts in concert with MRN and ataxia telangiectasia-mutated to regulate resection and thus DNA repair pathway choice. ..
  16. Squatrito M, Brennan C, Helmy K, Huse J, Petrini J, Holland E. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell. 2010;18:619-29 pubmed publisher
    ..encoding components of the DDR pathway are frequently altered in human gliomas and that loss of elements of the ATM/Chk2/p53 cascade accelerates tumor formation in a glioma mouse model...
  17. Song L, Lin C, Wu Z, Gong H, Zeng Y, Wu J, et al. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PLoS ONE. 2011;6:e25454 pubmed publisher
    ..b>Ataxia Telangiectasia Mutated (ATM) Kinase, which functions as the primary sensor and transducer of DNA damage signal, has been ..
  18. Bueno R, Canevari R, Villacis R, Domingues M, Caldeira J, Rocha R, et al. ATM down-regulation is associated with poor prognosis in sporadic breast carcinomas. Ann Oncol. 2014;25:69-75 pubmed publisher
    Ataxia telangiectasia-mutated (ATM) gene downexpression has been reported in sporadic breast carcinomas (BC); however, the prognostic value and mechanisms of ATM deregulation remain unclear...
  19. Norman J, Mashiba M, McNamara L, Onafuwa Nuga A, Chiari Fort E, Shen W, et al. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. Nat Immunol. 2011;12:975-83 pubmed publisher
    ..Our results show that pathogen-induced deamination of cytidine and the DNA-damage response to virus-mediated repair of the incorporation of uridine enhance the recognition of HIV-infected cells by NK cells. ..
  20. Shen L, Yin Z, Wan Y, Zhang Y, Li K, Zhou B. Association between ATM polymorphisms and cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:5719-25 pubmed publisher
    To date, epidemiological studies have assessed the association between Ataxia-telangiectasia mutated (ATM) gene polymorphisms and cancer risk, including lung cancer, breast cancer, glioma and pancreatic cancer...
  21. Gatei M, Jakob B, Chen P, Kijas A, Becherel O, Gueven N, et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem. 2011;286:31542-56 pubmed publisher
    ..the recent description of a patient with Rad50 deficiency characterized by chromosomal instability and defective ATM-dependent signaling...
  22. Wang H, Chang W, Tsai R, Tsai C, Liu L, Su C, et al. Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females. Anticancer Res. 2010;30:5217-21 pubmed
    Several epidemiological studies have investigated the association between ataxia telangiectasia mutated (ATM) gene polymorphisms and breast cancer risk...
  23. Hadian K, Krappmann D. Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response. Sci Signal. 2011;4:pe2 pubmed publisher
    ..The kinase ataxia telangiectasia mutated (ATM) has a critical role in the activation of NF-?B in response to genotoxic stress...
  24. Woodbine L, Brunton H, Goodarzi A, Shibata A, Jeggo P. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Res. 2011;39:6986-97 pubmed publisher
    Ataxia telangiectasia (ATM) mutated and Artemis, the proteins defective in ataxia telangiectasia and a class of Radiosensitive-Severe Combined Immunodeficiency (RS-SCID), respectively, function in the repair of DNA double strand breaks (..
  25. Skowronska A, Parker A, Ahmed G, Oldreive C, Davis Z, Richards S, et al. Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial. J Clin Oncol. 2012;30:4524-32 pubmed publisher
    The prognostic significance of ATM mutations in chronic lymphocytic leukemia (CLL) is unclear. We assessed their impact in the context of a prospective randomized trial...
  26. Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, et al. DNA damage-induced activation of ATM promotes ?-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012;3:1026-35 pubmed
    ..Consistent with previous studies, we found that inactivation of the Ataxia Telangiectasia Mutated (ATM) kinase, in turn, impaired DNA damage-induced Mdm2 destruction...
  27. FOSTER C, Zha Q, Daniel L, Singh M, Singh K. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in ?-adrenergic receptor-stimulated apoptosis. Exp Physiol. 2012;97:506-15 pubmed publisher
    b>Ataxia telangiectasia mutated kinase (ATM) is involved in cell cycle checkpoints, DNA repair and apoptosis. ?-Adrenergic receptor (?-AR) stimulation induces cardiac myocyte apoptosis...
  28. Roberts N, Jiao Y, Yu J, Kopelovich L, Petersen G, Bondy M, et al. ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov. 2012;2:41-6 pubmed publisher
    ..including whole-genome and whole-exome analyses, and identified heterozygous, constitutional, ataxia telangiectasia mutated (ATM) gene mutations in 2 kindreds with familial pancreatic cancer...
  29. Gilardini Montani M, Prodosmo A, Stagni V, Merli D, Monteonofrio L, Gatti V, et al. ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition. J Exp Clin Cancer Res. 2013;32:95 pubmed publisher
    ..The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate-risk factor for ..
  30. Xiong H, Liao Z, Liu Z, Xu T, Wang Q, Liu H, et al. ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Int J Radiat Oncol Biol Phys. 2013;85:1066-73 pubmed publisher
    The ataxia telangiectasia mutated (ATM) gene mediates detection and repair of DNA damage. We investigated associations between ATM polymorphisms and severe radiation-induced pneumonitis (RP)...
  31. Alagoz M, Chiang S, Sharma A, El Khamisy S. ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. PLoS ONE. 2013;8:e58239 pubmed publisher
    ..We subsequently employed this assay to reveal an increased steady state level of Top1-CCs in neural cells lacking Atm; the protein mutated in ataxia telangiectasia...
  32. Wang C, Wu K, Yang Y, Peng C, Tsai F, Lin D, et al. Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan. Chin J Physiol. 2011;54:413-8 pubmed publisher
    The ataxia telangiectasia mutated (ATM) gene plays a major role in repairing the double-strand breaks and maintaining the genome stability...
  33. Smith J, Tho L, Xu N, Gillespie D. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res. 2010;108:73-112 pubmed publisher
    ..Cellular responses to DNA damage are coordinated primarily by two distinct kinase signaling cascades, the ATM-Chk2 and ATR-Chk1 pathways, which are activated by DNA double-strand breaks (DSBs) and single-stranded DNA ..
  34. Lee S, Lee K, Lee S, Yoo K, Park S, Noh D, et al. Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk. Nutr Cancer. 2010;62:1087-94 pubmed publisher
    b>Ataxia telangiectasia mutated (ATM) cells exist under a constant state of oxidative stress with high levels of reactive oxygen species, which are removed by cellular antioxidant vitamins...
  35. Cam H, Easton J, High A, Houghton P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1?. Mol Cell. 2010;40:509-20 pubmed publisher
    ..Here we show that hypoxia results in ataxia telangiectasia mutated (ATM)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (HIF-1?) on serine(696) and ..
  36. Bensimon A, Schmidt A, Ziv Y, Elkon R, Wang S, Chen D, et al. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal. 2010;3:rs3 pubmed publisher
    ..The main transducer of the DSB response is the nuclear protein kinase ataxia telangiectasia mutated (ATM)...
  37. Kozlov S, Graham M, Jakob B, Tobias F, Kijas A, Tanuji M, et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem. 2011;286:9107-19 pubmed publisher
    ..signaling of DNA double strand breaks involves the participation of multiple proteins, including the protein kinase ATM (mutated in ataxia-telangiectasia)...
  38. Khalil A, Morgan R, Adams B, Golding S, Dever S, Rosenberg E, et al. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle. 2011;10:481-91 pubmed
    ..2 - 20 Gy, as determined by pulsed-field gel electrophoresis, and accompanied by dose-dependent ATM (ser-1981), H2AX (ser-139), Chk2 (thr-68), and p53 (ser-15) phosphorylation...
  39. Wood L, Sankar S, Reed R, Haas A, Liu L, MCKINNON P, et al. A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway. PLoS ONE. 2011;6:e16422 pubmed publisher
    Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis...
  40. Micol R, Ben Slama L, Suarez F, Le Mignot L, Beauté J, Mahlaoui N, et al. Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype. J Allergy Clin Immunol. 2011;128:382-9.e1 pubmed publisher
    ..A-T) is a rare genetic disease caused by germline biallelic mutations in the ataxia-telangiectasia mutated gene (ATM) that result in partial or complete loss of ATM expression or activity...
  41. Roossink F, Wieringa H, Noordhuis M, ten Hoor K, Kok M, Slagter Menkema L, et al. The role of ATM and 53BP1 as predictive markers in cervical cancer. Int J Cancer. 2012;131:2056-66 pubmed publisher
    ..In a panel of cervical cancer cell lines, inactivation of ataxia telangiectasia mutated (ATM) or its substrate p53-binding protein-1 (53BP1) clearly gave rise to cell cycle defects in ..
  42. Wang H, Shi Y, Li Q, Liu Y, Zheng X. [Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1863-6 pubmed
    ..the correlation between single nucleotide polymorphisms (SNP) in the promoter of ataxia-telangiectasia mutated (ATM) gene and the susceptibility of nasopharyngeal carcinoma in Cantonese...
  43. Lin K, Adamson J, Johnson G, Carter A, Oates M, Wade R, et al. Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration. Clin Cancer Res. 2012;18:4191-200 pubmed publisher
    This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline ..
  44. Shen L, Yin Z, Wu W, Ren Y, Li X, Zhou B. Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study. PLoS ONE. 2014;9:e96911 pubmed publisher
    The ataxia-telangiectasia mutated (ATM) gene plays an important role in the DNA double-strand breaks repair pathway. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence the risk of lung cancer...
  45. Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, et al. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. PLoS ONE. 2010;5:e13554 pubmed publisher
    ..Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a DNA damage signaling regulator, increases the incidence of chromosome translocations...
  46. Lozanski G, Ruppert A, Heerema N, Lozanski A, Lucas D, Gordon A, et al. Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study. Leuk Lymphoma. 2012;53:1743-8 pubmed publisher
    The impact of mutation of the ATM (ataxia telangiectasia mutated) gene in chronic lymphocytic leukemia (CLL) treatment outcome has not been examined. We studied ATM mutations in 73 patients treated with fludarabine and rituximab...
  47. Hsia T, Tsai C, Liang S, Chang W, Lin L, Chen W, et al. Effects of ataxia telangiectasia mutated (ATM) genotypes and smoking habits on lung cancer risk in Taiwan. Anticancer Res. 2013;33:4067-71 pubmed
    The study aimed to evaluate the association and interaction of ataxia telangiectasia mutated (ATM) genetic polymorphisms with lung cancer risk in Taiwan, where lung cancer is the primary cause of cancer-related death...
  48. Bau D, Chang C, Tsai M, Chiu C, Tsou Y, Wang R, et al. Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility. Laryngoscope. 2010;120:2417-22 pubmed publisher
    The ataxia-telangiectasia mutated (ATM) is thought to play a major role in the caretaking of the overall genome stability, and its mutations have been implicated in human cancers...
  49. Sowd G, Li N, Fanning E. ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication. PLoS Pathog. 2013;9:e1003283 pubmed publisher
    Mutation of DNA damage checkpoint signaling kinases ataxia telangiectasia-mutated (ATM) or ATM- and Rad3-related (ATR) results in genomic instability disorders...
  50. Guarini A, Marinelli M, Tavolaro S, Bellacchio E, Magliozzi M, Chiaretti S, et al. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. Haematologica. 2012;97:47-55 pubmed publisher
    ..Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progression...
  51. Kim H, Kim M, Hodgson D, Harbron C, Wellings R, O Connor M, et al. Concordance of ATM (ataxia telangiectasia mutated) immunohistochemistry between biopsy or metastatic tumor samples and primary tumors in gastric cancer patients. Pathobiology. 2013;80:127-37 pubmed publisher
    ATM (ataxia telangiectasia mutated) is one of several DNA repair proteins that are suggested to sensitize tumor cells to the poly(ADP-ribose) polymerase inhibitor olaparib when deficient...
  52. Cosentino C, Grieco D, Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J. 2011;30:546-55 pubmed publisher
    Ataxia telangiectasia (A-T) is a human disease caused by ATM deficiency characterized among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and neurological defects...
  53. Demuth I, Dutrannoy V, Marques W, Neitzel H, Schindler D, Dimova P, et al. New mutations in the ATM gene and clinical data of 25 AT patients. Neurogenetics. 2011;12:273-82 pubmed publisher
    ..The gene mutated in the patients, ATM, encodes a member of the phosphatidylinositol 3-kinase family proteins...
  54. Daniel J, Pellegrini M, Lee B, Guo Z, Filsuf D, Belkina N, et al. Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol. 2012;198:295-304 pubmed publisher
    Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis...
  55. Ambrose M, Gatti R. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood. 2013;121:4036-45 pubmed publisher
    ..Many independent laboratories have since demonstrated that in replicating cells, ataxia telangiectasia mutated (ATM) is predominantly a nuclear protein that is involved in the early recognition and response to ..
  56. Nakamura K, Du L, Tunuguntla R, Fike F, Cavalieri S, Morio T, et al. Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxia-telangiectasia. Hum Mutat. 2012;33:198-208 pubmed publisher
    ..We studied ATM mutations in eight families of Japanese A-T patients (JPAT) and were able to identify all 16 mutations...
  57. Salimi M, Mozdarani H, Majidzadeh K. Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients. Med Oncol. 2012;29:1502-9 pubmed publisher
    b>ATM protein kinase plays a critical role in maintaining genome integrity by activating a biochemical chain reaction that in turn leads to cell cycle checkpoint activation and repair of DNA damage...
  58. Jiang M, Zhao L, Gamez M, Imperiale M. Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection. PLoS Pathog. 2012;8:e1002898 pubmed publisher
    ..Our results showed that both the ataxia-telangiectasia mutated (ATM)- and ATM and Rad-3-related (ATR)-mediated DDR were activated during BKPyV infection, accompanied by the ..
  59. Moyal L, Lerenthal Y, Gana Weisz M, Mass G, So S, Wang S, et al. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell. 2011;41:529-42 pubmed publisher
    The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATM controls DSB repair...
  60. Goetz E, Shankar B, Zou Y, Morales J, Luo X, Araki S, et al. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene. 2011;30:3745-54 pubmed publisher
    ..Here, we show that activation of Ataxia telangiectasia-mutated kinase (ATM) by endogenous or exogenous forms of DNA damage was required to relieve basal repression of IGF-1 transcription by ..
  61. Guo Z, Kozlov S, Lavin M, Person M, Paull T. ATM activation by oxidative stress. Science. 2010;330:517-21 pubmed publisher
    The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and orchestrates signaling cascades that initiate the DNA damage response...
  62. Li J, Chen J, Vinters H, Gatti R, Herrup K. Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci. 2011;31:7568-77 pubmed publisher
    The gene that is mutated in ataxia-telangiectasia (A-T), ATM, is catalytically activated in response to DNA damage. Yet a full accounting for the CNS deficits in human A-T or its mouse models remains elusive...
  63. Yamamoto K, Wang Y, Jiang W, Liu X, Dubois R, Lin C, et al. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol. 2012;198:305-13 pubmed publisher
    Ataxia telangiectasia (A-T) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA) damage responses by phosphorylating numerous substrates implicated in DNA repair and cell cycle checkpoint activation...
  64. Wu C, Dong Y, Liang Q, He X, Ng S, Chan F, et al. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PLoS ONE. 2013;8:e57036 pubmed publisher
    ..0001). Through in silico search, the 3'UTR of Ataxia telangiectasia mutated (ATM) contains a conserved miR-18a binding site...