ATIC

Summary

Gene Symbol: ATIC
Description: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Alias: AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, bifunctional purine biosynthesis protein PURH, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase, AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme, AICARFT/IMPCHASE, epididymis secretory sperm binding protein Li 70p, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Species: human
Products:     ATIC

Top Publications

  1. Dervieux T, Furst D, Lein D, Capps R, Smith K, Walsh M, et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum. 2004;50:2766-74 pubmed
    ..to MTX polyglutamates (MTXPGs) and inhibition of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (TS)...
  2. Dervieux T, Furst D, Lein D, Capps R, Smith K, Caldwell J, et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann Rheum Dis. 2005;64:1180-5 pubmed
    ..pharmacogenetic index comprising low penetrance genetic polymorphisms in reduced folate carrier (RFC-1 G80A), AICAR transformylase (ATIC C347G), and thymidylate synthase (TSER*2/*3) was calculated...
  3. Weisman M, Furst D, Park G, Kremer J, Smith K, Wallace D, et al. Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum. 2006;54:607-12 pubmed
    ..synthase (TSER) *2/*2 (variable number of tandem repeats), amino imidazole ribonucleotide transformylase (ATIC) 347GG, and serine hydroxymethyltransferase (SHMT1) 1420CC were measured and summed to constitute the toxicogenetic ..
  4. Wessels J, Kooloos W, de Jonge R, de Vries Bouwstra J, Allaart C, Linssen A, et al. Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 2006;54:2830-9 pubmed
    ..The following polymorphisms were determined: AMPD1 34C>T, ATIC 347C>G, ITPA 94C>A, MTR 2756A>G, and MTRR 66A>G...
  5. Dervieux T, Greenstein N, Kremer J. Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum. 2006;54:3095-103 pubmed
    ..RBC MTXPG levels are a useful means by which to monitor therapy. The genetic associations presented generate hypotheses, and confirmation in independent cohorts is warranted. ..
  6. Campalani E, Arenas M, Marinaki A, Lewis C, Barker J, Smith C. Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. J Invest Dermatol. 2007;127:1860-7 pubmed
    ..025 and P=0.025, respectively). RFC 80A and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) 347G were associated with methotrexate discontinuation (P=0.048 and P=0.038)...
  7. Wessels J, van der Kooij S, le Cessie S, Kievit W, Barerra P, Allaart C, et al. A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum. 2007;56:1765-75 pubmed
    ..for MTX efficacy consisted of sex, rheumatoid factor and smoking status, the DAS, and 4 polymorphisms in the AMPD1, ATIC, ITPA, and MTHFD1 genes. This prediction model was transformed into a scoring system ranging from 0 to 11.5...
  8. Lee Y, Cui J, Costenbader K, Shadick N, Weinblatt M, Karlson E. Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology (Oxford). 2009;48:613-7 pubmed publisher
    ..2. Low disease activity was defined as DAS28-CRP < or =3.2. We studied three candidate alleles in the ATIC, ITPA and MTHFR genes for association with DAS28-CRP...
  9. Deng W, Yang Y, Gao P, Chen H, Wen W, Sun Q. Radiation-Resistant Micrococcus luteus SC1204 and Its Proteomics Change Upon Gamma Irradiation. Curr Microbiol. 2016;72:767-75 pubmed publisher
    ..The next abundant protein was phosphoribosyl aminoimidazole carboxamide formyltransferase/IMP cyclohydrolase (AICAR Tfase/IMPCH), the key enzyme in the biosynthetic pathway of purine that is anti-radiation compound...

More Information

Publications126 found, 100 shown here

  1. Nguyen T, Seigneurin F, Froment P, Combarnous Y, Blesbois E. The 5'-AMP-Activated Protein Kinase (AMPK) Is Involved in the Augmentation of Antioxidant Defenses in Cryopreserved Chicken Sperm. PLoS ONE. 2015;10:e0134420 pubmed publisher
    ..Chicken semen was diluted in media supplemented with or without AMPK activators (AICAR or Metformin [MET]) or inhibitor (Compound C [CC]) and then cryopreserved...
  2. Chantong B, Kratschmar D, Lister A, Odermatt A. Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells. J Neuroinflammation. 2014;11:190 pubmed publisher
    ..Pretreatment with the AMPK agonist AICAR partially abolished, whilst the inhibitor compound C potentiated, the MPEP-dependent ER-stress...
  3. Lee J, Hong S, Park S, Rhee E, Park C, Oh K, et al. Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK. Endocrinol Metab (Seoul). 2015;30:177-84 pubmed publisher
    ..In cells treated with the AMPK activator 5-aminoidazole-4-carboxamide ribonucleotide (AICAR), the expression of hepatic SEPP1 and fetuin-A were negatively related by AMPK, which is the target of exendin-4...
  4. Tong X, Kono T, Evans Molina C. Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability. Cell Death Dis. 2015;6:e1790 pubmed publisher
    ..L-arginine), whereas the NO donor SNAP (S-nitroso-N-acetyl-D,L-penicillamine) and the AMPK activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) recapitulated the effects of IL-1β on SERCA2b protein stability...
  5. Jiang S, Dong H, Li J, Xu L, Zou X, Wang K, et al. Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J Gastroenterol. 2015;21:7777-85 pubmed publisher
    ..was intragastrically administered to the diabetic rats and 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) (0.5 mg/kg per day) (AICAR group) was subcutaneously injected to the diabetic rats for 12 wk...
  6. Mulchandani N, Yang W, Khan M, Zhang F, Marambaud P, Nicastro J, et al. Stimulation of Brain AMP-Activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis. Mol Med. 2015;21:637-44 pubmed publisher
    ..Adult C57BL/6 male mice were treated with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR, 20 ng), an AMPK activator, or vehicle (normal saline) by intracerebroventricular (ICV) injection, followed by ..
  7. Seo H, Baek S, Lee E, Lee J, Lee S, Kim K, et al. Liqustri lucidi Fructus inhibits hepatic injury and functions as an antioxidant by activation of AMP-activated protein kinase in vivo and in vitro. Chem Biol Interact. 2017;262:57-68 pubmed publisher
    ..caused by AA + iron, which were similar with the effect of aminoimidazole-carboxamide-?-d-ribofuranoside (AICAR)...
  8. Harada M, Tadevosyan A, Qi X, Xiao J, Liu T, Voigt N, et al. Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression. J Am Coll Cardiol. 2015;66:47-58 pubmed publisher
    ..The AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) increased CaT amplitude and CS, restoring CompC-induced CaT and CS decreases...
  9. Guo L, Costanzo Garvey D, Smith D, Neilsen B, MacDonald R, Lewis R. Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis. Mol Metab. 2017;6:194-205 pubmed publisher
    ..Growth, body composition, food consumption, cold tolerance, insulin and free fatty acid levels, glucose, and AICAR tolerance were measured in gender and age matched KSR2-/- mice...
  10. Javadov S, Rajapurohitam V, Kilic A, Zeidan A, Choi A, Karmazyn M. Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. J Mol Cell Cardiol. 2009;46:998-1007 pubmed publisher
    ..inhibitor VIII), ERK1/2 (PD98059) and by the AMPK agonist 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)...
  11. Bremer K, Kocha K, Snider T, Moyes C. Sensing and responding to energetic stress: The role of the AMPK-PGC1α-NRF1 axis in control of mitochondrial biogenesis in fish. Comp Biochem Physiol B Biochem Mol Biol. 2016;199:4-12 pubmed publisher
    ..b>AICAR treatment of zebrafish blastula cells increased phosphorylation of AMPK and led to changes in transcript levels of ..
  12. Harfmann B, Schroder E, Kachman M, Hodge B, Zhang X, Esser K. Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis. Skelet Muscle. 2016;6:12 pubmed publisher
    ..digitorum longus (EDL) muscles did not respond to either insulin or 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) stimulation...
  13. Kou B, Liu W, Xu X, Yang Y, Yi Q, Guo F, et al. Autophagy induction enhances tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human bladder cancer cells. Oncol Rep. 2017;38:3137-3143 pubmed publisher
    ..Moreover, AICAR, a common AMPK activator, further increased the expression the LC3-II, while AMPK inhibitor compound C partially ..
  14. Tsujimoto S, Yanagimachi M, Tanoshima R, Urayama K, Tanaka F, Aida N, et al. Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies. Pediatr Blood Cancer. 2016;63:1983-9 pubmed publisher
    ..MTX and its metabolites inhibit 5-aminoimidazole-4-carboxamide ribonucleotide formiltransferase (ATIC) and promote adenosine release...
  15. Klingbeil L, Kim P, Piraino G, O Connor M, Hake P, Wolfe V, et al. Age-Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock. Am J Respir Cell Mol Biol. 2017;56:585-596 pubmed publisher
    ..in hemorrhage-induced lung injury and whether AMPK activation by 5-amino-4-imidazole carboxamide riboside (AICAR) affords lung protective effects...
  16. Sun G, Da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson D, et al. LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Mol Metab. 2015;4:277-86 pubmed publisher
    ..in male αLKB1KO mice were lower during intraperitoneal glucose, aminoimidazole carboxamide ribonucleotide (AICAR) or arginine tolerance tests, and glucose infusion rates were increased in hypoglycemic clamps (p < 0.01)...
  17. Winder W, Holmes B, Rubink D, Jensen E, Chen M, Holloszy J. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol (1985). 2000;88:2219-26 pubmed
    ..studies, rats were subcutaneously injected with either 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR; 1 mg/g body wt) in 0.9% NaCl or with 0...
  18. Sun X, Yang Q, Rogers C, Du M, Zhu M. AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression. Cell Death Differ. 2017;24:819-831 pubmed publisher
    ..In this study, AMPK activator (AICAR) improved the barrier function of Caco-2 cells as indicated by increased transepithelial electrical resistance and ..
  19. Shimoda Y, Matsuo K, Kitamura Y, Ono K, Ueyama T, Matoba S, et al. Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle. PLoS ONE. 2015;10:e0138624 pubmed publisher
    ..DARP-silencing increased glucose uptake and oxidation in myotubes, which was abrogated by the treatment with AICAR, an AMPK activator...
  20. Marmolino D, Manto M, Acquaviva F, Vergara P, Ravella A, Monticelli A, et al. PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. PLoS ONE. 2010;5:e10025 pubmed publisher
    ..activation with the PPARgamma agonist (Pioglitazone) or with a cAMP-dependent protein kinase (AMPK) agonist (AICAR) restored normal SOD2 induction...
  21. Liu J, Zhang L, Yao J, Yao S, Yuan T. AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis. Biochem Biophys Res Commun. 2018;497:564-570 pubmed publisher
    ..However, co-treatment with N1-(β-d-ribofuranosyl)-5-aminoimidazole-4-carboxamide (AICAR), a pharmacological activator of AMPK, significantly increased cell protection against ER stress-induced apoptosis ..
  22. Moreno Arriola E, El Hafidi M, Ortega Cuéllar D, Carvajal K. AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators. PLoS ONE. 2016;11:e0148089 pubmed publisher
    ..Similar to mammals, AAK is activated by AICAR and metformin and leads to increased glycolytic and oxidative metabolic fluxes evidenced by an increase in lactate ..
  23. Takeoka K, Okumura A, Honjo G, Ohno H. Variant translocation partners of the anaplastic lymphoma kinase (ALK) gene in two cases of anaplastic large cell lymphoma, identified by inverse cDNA polymerase chain reaction. J Clin Exp Hematop. 2014;54:225-35 pubmed
    ..Nucleotide sequencing of the PCR products and a database search revealed that the sequences of ATIC in case 1 and TRAF1 in case 2 appeared to follow those of ALK...
  24. Takahashi S, Iizumi T, Mashima K, Abe T, Suzuki N. Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia. ASN Neuro. 2014;6: pubmed publisher
    ..KB production in astroglia was augmented by the AMP-activated protein kinase activators, AICAR and metformin, as well as hypoxia with/without glucose...
  25. Iwamoto T, Nakamura T, Ishikawa M, Yoshizaki K, Sugimoto A, Ida Yonemochi H, et al. Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities. PLoS ONE. 2017;12:e0177557 pubmed publisher
    ..5-Aminoimidazole-4-carboxamide-ribonucleoside (AICAR), an activator of AMPK, reduced mDP cell proliferation and induced p21 expression...
  26. Kwok W, Choi T, Kwok K, Chan G, Wong J, Wan T. Doping control analysis of 46 polar drugs in horse plasma and urine using a 'dilute-and-shoot' ultra high performance liquid chromatography-high resolution mass spectrometry approach. J Chromatogr A. 2016;1451:41-49 pubmed publisher
    ..anti-epileptics, hemostatics, the new doping agent 5-aminoimidazole-4-carboxamide-1-?-d-ribofuranoside (AICAR), as well as two threshold substances, namely dimethyl sulfoxide and theobromine...
  27. King Himmelreich T, Möser C, Wolters M, Schmetzer J, Schreiber Y, Ferreirós N, et al. AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids. Neuropharmacology. 2017;124:134-142 pubmed publisher
    ..mice received AM251 in combination with the AMPK activator 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide (AICAR), the positive effect of treadmill running on inflammatory nociception was restored, indicating that AMPK affects ..
  28. Nguyen G, Park S, Le C, Park W, Choi D, Cho E. Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition. Biochem Biophys Res Commun. 2018;495:2649-2656 pubmed publisher
    ..In our study, metformin and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), which is an analog of adenosine monophosphate, were shown to suppress α-SMA expression via enhanced ..
  29. Takatori R, Takahashi K, Tokunaga D, Hojo T, Fujioka M, Asano T, et al. ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients. Clin Exp Rheumatol. 2006;24:546-54 pubmed
    ..ABCB1) C3435T, reduced folate carrier-1 (RFC1) G80A, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) C347G and a 6bp-deletion polymorphism in the 3'-untranslated region of the thymidylase synthase (TYMS) gene are ..
  30. Bazurto J, Heitman N, Downs D. Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica. J Bacteriol. 2015;197:2821-30 pubmed publisher
    ..This secondary route to AIR synthesis is dependent on (i) 5-amino-4-imidazolecarboxamide ribotide (AICAR) accumulation, (ii) a functional phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase (PurC; EC 6.3...
  31. Kim B, Figueroa Romero C, Pacut C, Backus C, Feldman E. Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation. J Biol Chem. 2015;290:19146-57 pubmed publisher
    ..mouse embryonic cortical neurons with the AMPK activator, 5-aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR), induced AMPK phosphorylation at both Thr-172 and Ser-485. AMPK activation also triggered Tau dephosphorylation...
  32. Khan M, Dhammu T, Matsuda F, Singh A, Singh I. Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy. BMC Neurosci. 2015;16:42 pubmed publisher
    ..To determine whether AMPK activation is deleterious in the acute phase of IR, we treated animals after IR with AICAR (an AMPK activator) and compound c (an AMPK inhibitor). While AICAR potentiated, compound c reduced the IR injury...
  33. Ren J, Xu X, Wang Q, Ren S, Dong M, Zhang Y. Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia. J Mol Cell Cardiol. 2016;93:18-31 pubmed publisher
    ..In vivo administration of AMPK activator AICAR or the autophagy inducer rapamycin effectively attenuated or obliterated LPS-induced and adiponectin deficiency-..
  34. Cheng X, Li Y, Huang C, Li J, Yao H. AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. Oncotarget. 2017;8:22513-22523 pubmed publisher
    ..cells (SAECs) were treated with cigarette smoke extract (CSE) in the presence of a specific AMPK activator (AICAR, 1 mM) and inhibitor (Compound C, 5 ?M)...
  35. Shaw A, Jeromson S, Watterson K, Pediani J, Gallagher I, Whalley T, et al. Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes. Am J Physiol Cell Physiol. 2017;312:C689-C696 pubmed publisher
    ..function [sodium azide (75 ?M), rotenone (1 ?M), berberine (100 ?M), DNP (500 ?M)], or directly activate AMPK [AICAR (250 ?M)] were assessed for their ability to regulate l-carnitine uptake...
  36. Albrecht D, Ceschin J, Dompierre J, Gueniot F, Pinson B, Daignan Fornier B. Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans. Genetics. 2016;204:1447-1460 pubmed
    ..to screen for mutations resulting in a synthetic lethality with 5-amino-4-imidazole carboxamide ribonucleoside (AICAR) treatment. Indeed, AICAR has been reported to inhibit the proliferation of multiple cancer cell lines...
  37. Qin X, Qiao H, Wu S, Cheng J, Wan Q, Liu R. Curcumin Inhibits Monocyte Chemoattractant Protein-1 Expression in TNF-α induced Astrocytes Through AMPK Pathway. Neurochem Res. 2018;43:775-784 pubmed publisher
    ..Furthermore, the specific AMPK activator AICAR (5-aminoimidazole-4-carboxamide 1-D-ribofuranoside) mimicked the effects of Curcumin, whereas a selective AMPK ..
  38. Mailleux F, Beauloye C, Balligand J, Horman S, Bertrand L. Studying the Role of AMPK in Cardiac Hypertrophy and Protein Synthesis. Methods Mol Biol. 2018;1732:321-342 pubmed publisher
    ..Two different compounds, AICAr and the biguanide phenformin, were used to promote AMPK activation.
  39. Alenazi F, Ibrahim B, Briski K. Estradiol Regulates Dorsal Vagal Complex Signal Transduction Pathway Transcriptional Reactivity to the AMPK Activator 5-Aminoimidazole-4-Carboxamide-Riboside (AICAR). J Mol Neurosci. 2015;56:907-16 pubmed publisher
    ..rats injected into the caudal fourth ventricle with the AMP mimetic 5-aminoimidazole-4-carboxamide-riboside (AICAR) (A) or saline (S)...
  40. Xie W, Wang L, Dai Q, Yu H, He X, Xiong J, et al. Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation. J Mol Cell Cardiol. 2015;85:155-67 pubmed publisher
    ..could be inhibited by several different pharmacological AMPK activators including metformin, A769662 and AICAR. And the constitutively active AMPK mutant (CA-AMPK) could also inhibit the CVB3 replication...
  41. Wang L, Di L. Wnt/β-Catenin Mediates AICAR Effect to Increase GATA3 Expression and Inhibit Adipogenesis. J Biol Chem. 2015;290:19458-68 pubmed publisher
    ..Here, we report that the AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) can activate AMPK in preadipocytes and thus increase the expression of GATA3, an anti-adipogenic factor...
  42. Guerrieri D, van Praag H. Exercise-mimetic AICAR transiently benefits brain function. Oncotarget. 2015;6:18293-313 pubmed
    ..the effects of running and administration of AMPK agonist 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR, 500 mg/kg), for 3, 7 or 14 days in one-month-old male C57BL/6J mice, on muscle AMPK signaling...
  43. Wang Z, Xiong F, Wang X, Qi Y, Yu H, Zhu Y, et al. Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer. Oncotarget. 2017;8:11105-11113 pubmed publisher
    ..reduction is due to the reduced activation of AMP-activated protein kinase (AMPK), as a selective AMPK activator AICAR increased ROR? activation and level in human gastric cancer cells...
  44. Bizjak M, Malavašič P, Dolinar K, Pohar J, Pirkmajer S, Pavlin M. Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro. Sci Rep. 2017;7:1761 pubmed publisher
    ..However, direct AMPK activators A-769662 and AICAR did not have any major effect on the percentage of floating MDA-MB-231 cells, indicating that AMPK activation is ..
  45. Mukhopadhyay R, Venkatadri R, Katsnelson J, Arav Boger R. Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase ?1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation. J Virol. 2018;92: pubmed publisher
    ..Drug combination studies with digitoxin and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) further confirmed the role of autophagy activation in HCMV inhibition...
  46. Chen B, Li J, Zhu H. AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway. Vascul Pharmacol. 2016;85:1-10 pubmed publisher
    ..Here we demonstrate that AMPK activation in response to IMM-H007 or AICAR resulted in a decrease in macrophage cholesterol uptake and thus inhibited foam cell formation in macrophages ..
  47. Pigna E, Berardi E, Aulino P, Rizzuto E, Zampieri S, Carraro U, et al. Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer. Sci Rep. 2016;6:26991 pubmed publisher
    ..Treatment of C26-bearing mice with either AICAR or rapamycin, two drugs that trigger the autophagic flux, also rescued muscle mass and prevented atrogene ..
  48. Kjøbsted R, Munk Hansen N, Birk J, Foretz M, Viollet B, Björnholm M, et al. Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK. Diabetes. 2017;66:598-612 pubmed publisher
    ..Using AICAR, we recently demonstrated that prior activation of AMPK is sufficient to increase insulin sensitivity in mouse ..
  49. Hansen A, Ramakrishnan N, Sunil Kumar P, Ipsen J. Numerical insights into the phase diagram of p-atic membranes with spherical topology. Eur Phys J E Soft Matter. 2017;40:32 pubmed publisher
    The properties of self-avoiding p-atic membranes restricted to spherical topology have been studied by Monte Carlo simulations of a triangulated random surface model...
  50. Sanchez A, Candau R, Bernardi H. AMP-activated protein kinase stabilizes FOXO3 in primary myotubes. Biochem Biophys Res Commun. 2018;499:493-498 pubmed publisher
    ..First, time course and dose response studies revealed optimal AICAR treatment duration and dose in skeletal muscle cells...
  51. Lin K, Huang D, Huang D, Tzeng S, Lin W. Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. J Mol Med (Berl). 2016;94:183-94 pubmed publisher
    ..When AMPK was activated by AICAR, A769662 and metformin, FcεRI-mediated Syk, ERK, JNK and p38 activation, and TNFα release were all inhibited...
  52. Walter R, Mairinger F, Werner R, Vollbrecht C, Hager T, Schmid K, et al. Folic-acid metabolism and DNA-repair phenotypes differ between neuroendocrine lung tumors and associate with aggressive subtypes, therapy resistance and outcome. Oncotarget. 2016;7:20166-79 pubmed publisher
    ..Sixty patients were used for nCounter mRNA expression analysis of the folic-acid metabolism (ATIC, DHFR, FOLR1, FPGS, GART, GGT1, SLC19A1, TYMS) and DNA-repair (ERCC1, MLH1, MSH2, MSH6, XRCC1)...
  53. Guo Y, Meng J, Tang Y, Wang T, Wei B, Feng R, et al. AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Arch Biochem Biophys. 2016;600:56-60 pubmed publisher
    ..Recently, AMPK activation by AICAR has been shown to increase myofibrillar protein degradation in C2C12 myotubes via stimulating autophagy and ..
  54. Habib S, Yadav A, Kidane D, Weiss R, Liang S. Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage. Cell Cycle. 2016;15:3048-3059 pubmed
    ..In the present study, we investigated a potential mechanism by which AICAR treatment regulates the DNA repair enzyme, 8-oxoG-DNA glycosylase (OGG1) in renal proximal tubular mouse cells ..
  55. Tateishi Y, Okudela K, Kawai S, Suzuki T, Umeda S, Matsumura M, et al. Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report. Diagn Pathol. 2016;11:132 pubmed
    ..We herein report a case of intraosseous IMT of the mandible with a novel ATIC-ALK fusion...
  56. Verma P, Kar B, Varshney R, Roy P, Sharma A. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis. FEBS J. 2017;284:4233-4261 pubmed publisher
    ..was demonstrated in kinetic analysis of SlugATIC and reconstituted truncated N-terminal IMP cyclohydrolase (IMPCHase) and C-terminal AICAR transformylase (AICAR TFase) domains...
  57. Jian M, Liu Y, Li Q, WOLKOWICZ P, Alexeyev M, Zmijewski J, et al. N-cadherin coordinates AMP kinase-mediated lung vascular repair. Am J Physiol Lung Cell Mol Physiol. 2016;310:L71-85 pubmed publisher
    ..Moreover, the AMPK stimulator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) failed to increase AMPK activity in cells expressing the modified N-cadherin, indicating uncoupling of a ..
  58. Yu H, Fujii N, Toyoda T, An D, Farese R, Leitges M, et al. Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiol Rep. 2015;3: pubmed publisher
    ..protein kinase C (PKC) isoforms λ and ζ (PKC-λ/ζ) have been shown to be necessary for insulin-, AICAR-, and metformin-stimulated glucose uptake in skeletal muscle, but not for treadmill exercise-stimulated muscle ..
  59. Webb T, Carey G, East J, Sun W, Bollino D, Kimball A, et al. Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses. Pathog Dis. 2016;74: pubmed publisher
    ..Pretreatment with 2-deoxyglucose, cobalt chloride, AICAR and metformin significantly enhanced CD1d-mediated NKT-cell activation...
  60. Wang Y, Hong X, Wang J, Yin Y, Zhang Y, Zhou Y, et al. Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth. Oncogene. 2017;36:756-765 pubmed publisher
    ..inhibits AMPK? activation in response to nutrient depletion or 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), leading to attenuated phosphorylation of BRAF-S729 and retained mitogen-activated protein kinase (MAPK) ..
  61. Song Y, Zhang P, Sun Y, Li X, Chen L, Xiao Y, et al. AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells. Oncotarget. 2017;8:67942-67954 pubmed publisher
    ..In contrast, either autophagy activator rapamycin or AMPK activator acadesine (AICAR) compromised OA-induced anti-cancer effect...
  62. Guo X, Jiang Q, Tuccitto A, Chan D, Alqawlaq S, Won G, et al. The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury. Neurobiol Dis. 2018;113:59-69 pubmed publisher
    ..Furthermore, we demonstrate that therapeutic agonism of this pathway with the AMP mimetic, AICAR, rescues GSH levels in vivo, while reducing RGC death and astrocyte reactivity, following retinal ischemia/..
  63. Cao C, Gao T, Cheng Y, Cheng M, Su T, Xi F, et al. Hypothalamic AMPK-induced autophagy ameliorates hypercatabolism in septic rats by regulating POMC expression. Biochem Biophys Res Commun. 2018;497:1089-1096 pubmed publisher
    ..Hypercatabolism markers and neuropeptides expression were detected. Then, rats were injected with AICAR or saline into third ventricle and promptly intraperitoneally injected with LPS or saline...
  64. Yan T, Zhang J, Tang D, Zhang X, Jiang X, Zhao L, et al. Hypoxia Regulates mTORC1-Mediated Keratinocyte Motility and Migration via the AMPK Pathway. PLoS ONE. 2017;12:e0169155 pubmed publisher
    ..we found that the AMPK pathway activators Metformin (Met) and 5-Aminoimidazole-4-carboxamide 1-?-D-ribofuranoside (AICAR) decreased the mTORC1 activity, cell motility and lateral migration...
  65. Gao X, Yuan K, Cao L, Yan W, Luo Y, Jian M, et al. AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking. Sci Rep. 2017;7:1038 pubmed publisher
    ..activity by intra-NAc core infusions of the AMPK activator 5-amino-1-?-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) or adenovirus expressing constitutively active subunits of AMPK decreased cue-induced reinstatement of cocaine ..
  66. Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño K, Knierim A, et al. GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem J. 2017;474:983-1001 pubmed publisher
    ..Activation of AMPK in primary human endothelial cells by 5-aminoimidazole-4-carboxamide riboside (AICAR) or by vascular endothelial growth factor (VEGF) led to GFAT1 phosphorylation at serine 243...
  67. Eccardt A, Bell T, Mattathil L, Prasad R, Kelly S, Fisher J. Trans-Plasma Membrane Electron Transport and Ascorbate Efflux by Skeletal Muscle. Antioxidants (Basel). 2017;6: pubmed publisher
    ..adenosine 5'-monophosphate (AMP)-activated protein kinase activator 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) suppressed both tPMET and ascorbate efflux by myotubes, while insulin had no effect...
  68. Yamauchi M, Seki N, Mita K, Saito T, Tsuji S, Hongo E, et al. Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript. DNA Res. 1995;2:269-75 pubmed
    ..To assess the ability and usefulness of the procedure, we attempted to recover the human purH gene from a mouse transformant cell line, which was originally established by functional complementation using the ..
  69. Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K. Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. J Biochem. 1997;122:309-13 pubmed
    The cDNA encoding human 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase has been cloned from a placenta cDNA library, utilizing a PCR-derived probe. It encodes a peptide of 592 amino acids...
  70. Bulock K, Beardsley G, Anderson K. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J Biol Chem. 2002;277:22168-74 pubmed
    5-Amino-4-imidazolecarboxamide ribonucleotide transformylase/IMP cyclohydrolase (ATIC) is a bifunctional protein possessing two enzymatic activities that sequentially catalyze the last two steps in the pathway for de novo synthesis of ..
  71. Marie S, Heron B, Bitoun P, Timmerman T, Van den Berghe G, Vincent M. AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Am J Hum Genet. 2004;74:1276-81 pubmed
    ..of a massive excretion of 5-amino-4-imidazolecarboxamide (AICA)-riboside, the dephosphorylated counterpart of AICAR (also termed "ZMP"), an intermediate of de novo purine biosynthesis...
  72. Geraghty K, Chen S, Harthill J, Ibrahim A, Toth R, Morrice N, et al. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. Biochem J. 2007;407:231-41 pubmed
    ..was induced by IGF-1 (insulin-like growth factor-1), EGF (epidermal growth factor), PMA and, to a lesser extent, AICAR (5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside)...
  73. Boutchueng Djidjou M, Collard Simard G, Fortier S, Hébert S, Kelly I, Landry C, et al. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Mol Cell Proteomics. 2015;14:1079-92 pubmed publisher
    ..that IR internalization was markedly decreased after AMPKα2 knockdown, and treatment with the ATIC substrate AICAR, which is an allosteric activator of AMPK, increased IR endocytosis in cultured cells and in the liver...
  74. Muralidharan N, Mariaselvam C, Jain V, Gulati R, Negi V. ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis. Pharmacogenomics. 2016;17:241-8 pubmed publisher
    To find the association of ATIC 347C>G gene polymorphism with methotrexate (MTX) treatment response and MTX-induced adverse events in south Indian Tamil patients with rheumatoid arthritis...
  75. Kumar A, Giri S, Kumar A. 5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis. Cell Microbiol. 2016;18:1815-1830 pubmed publisher
    ..Intravitreal administration of an AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), restored AMPK? and acetyl-CoA carboxylase phosphorylation...
  76. Nie J, Liu A, Tan Q, Zhao K, Hu K, Li Y, et al. AICAR activates ER stress-dependent apoptosis in gallbladder cancer cells. Biochem Biophys Res Commun. 2017;482:246-252 pubmed publisher
    b>AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) is an AMP-activated protein kinase (AMPK) agonist, its activity in human gallbladder cancer cells was evaluated here...
  77. Chen Y, Chen C, Dong B, Xing F, Huang H, Yao F, et al. AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway. Eur J Pharmacol. 2017;814:335-342 pubmed publisher
    ..Mice with descending aortic banding (AB) or subjected to sham operation received subcutaneous injection of either AICAR (0.5mgg-1day-1) or vehicle over 4 week periods...
  78. Flanagan W, Holmes E, Sabina R, Swain J. Importance of purine nucleotide cycle to energy production in skeletal muscle. Am J Physiol. 1986;251:C795-802 pubmed
    ..or 5-amino-4-imidazolecarboxamide riboside (AICAriboside), a precursor to an inhibitor of adenylosuccinate lyase (AICAR)...
  79. Boccalatte F, Voena C, Riganti C, Bosia A, D Amico L, Riera L, et al. The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL. Blood. 2009;113:2776-90 pubmed publisher
    ..and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase (ATIC) associated with nucleophosmin (NPM)-ALK, and their phosphorylation required ALK activity...
  80. Wu Y, Liu G, Chen W, Yang M, Zhu C. 5-Aminoimidazole-4-carboxamide 1-?-D-ribofuranoside reduces intimal hyperplasia of tissue engineering blood vessel by inhibiting phenotype switch of vascular smooth muscle cell. J Biomed Mater Res B Appl Biomater. 2017;105:744-752 pubmed publisher
    ..In this article, 5-aminoimidazole-4-carboxamide 1-?-D-ribofuranoside (AICAR) was used in experiments after drug screening...
  81. Cheng F, He M, Jung J, Lu C, Gao S. Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase. J Virol. 2016;90:6515-6525 pubmed publisher
    ..lytic gene expressions and virion productions but an AMPK agonist, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), suppressed both...
  82. Zaitseva I, Zaitsev S, Berggren P. The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition. Invest New Drugs. 2016;34:522-9 pubmed publisher
    ..Activation of AMPK by 5-aminoimidazole-4-carboxamide riboside (AICAR) elevated basal and cytokine-induced death in primary ?-cells and in insulinoma MIN6 cells...
  83. Daglioglu C, Okutucu B. Therapeutic Effects of AICAR and DOX Conjugated Multifunctional Nanoparticles in Sensitization and Elimination of Cancer Cells via Survivin Targeting. Pharm Res. 2017;34:175-184 pubmed publisher
    ..and reported on producing multifunctional nanoparticles (Fe3O4@SiO2(FITC)-FA/AICAR/DOX) aiming to overcome chemoresistance with synergetic effect of AICAR and DOX...
  84. Castilla Madrigal R, Barrenetxe J, Moreno Aliaga M, Lostao M. EPA blocks TNF-?-induced inhibition of sugar uptake in Caco-2 cells via GPR120 and AMPK. J Cell Physiol. 2017;: pubmed publisher
    ..The ERK1/2 inhibitor PD98059 and the AMPK activator AICAR also prevented the inhibitory effect of TNF-? on both ?MG uptake and SGLT1 expression...
  85. Xiao Y, Chang W, Wu Q, Jiang X, Duan M, Jin Y, et al. Aucubin Protects against TGF?1-Induced Cardiac Fibroblasts Activation by Mediating the AMPK?/mTOR Signaling Pathway. Planta Med. 2018;84:91-99 pubmed publisher
    ..target of rapamycin (mTOR) phosphorylation, which was confirmed by an mTOR inhibitor (rapamycin), an AMPK agonist (AICAR) and an AMPK? inhibitor compound C...
  86. Tao X, Chen L, Cai L, Ge S, Deng X. Regulatory effects of the AMPK?-SIRT1 molecular pathway on insulin resistance in PCOS mice: An in vitro and in vivo study. Biochem Biophys Res Commun. 2017;494:615-620 pubmed publisher
    ..study of human granulosa KGN cells and in vivo study of PCOS mouse model which was constructed with DHEA, and AICAR and Compound C were applied...
  87. Wang R, Cheng Y, Su D, Gong B, He X, Zhou X, et al. Cpt1c regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions. J Cancer. 2017;8:3675-3681 pubmed publisher
    ..Lastly, KTC-1 cells were treated with AICAR (as an agonist of AMPK) and Compound C (as an inhibitor of AMPK) to investigate the correlation of AMPK activity ..
  88. Li H, Wu J, Zhu L, Sha L, Yang S, Wei J, et al. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. Biosci Rep. 2018;38: pubmed publisher
    ..PPAR? activator rosiglitazone (RSZ) or AMPK activator AICAR increased the expression level of IDE and decreased A? levels in mice with AD and T2D...
  89. Wang C, Wang Y, Di A, Magnuson M, Ye H, Roe M, et al. 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochem Biophys Res Commun. 2005;330:1073-9 pubmed
    ..We used 5-amino-imidazole carboxamide riboside (AICAR), an activator of AMPK, to define the signaling mechanisms linking the activation of AMPK with insulin secretion...
  90. Yin S, Li X, Meng Y, Finley R, Sakr W, Yang H, et al. Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase. J Biol Chem. 2005;280:34985-96 pubmed
  91. Warren R, Smith R, Campalani E, Eyre S, Smith C, Barker J, et al. Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. Br J Dermatol. 2009;160:438-41 pubmed publisher
    ..methylenetetrahydrofolate reductase (MTHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC)] are related to treatment outcomes in patients with psoriasis...
  92. Hazra A, Fuchs C, Kawasaki T, Kirkner G, Hunter D, Ogino S. Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. Cancer Causes Control. 2010;21:331-45 pubmed publisher
    ..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer. ..