ATG16L1

Summary

Gene Symbol: ATG16L1
Description: autophagy related 16 like 1
Alias: APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy-related protein 16-1, APG16L beta, ATG16 autophagy related 16-like 1, WD repeat domain 30
Species: human
Products:     ATG16L1

Top Publications

  1. Van Limbergen J, Russell R, Nimmo E, Drummond H, Smith L, Anderson N, et al. Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe. Inflamm Bowel Dis. 2008;14:338-46 pubmed
    The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults...
  2. Fujita N, Saitoh T, Kageyama S, Akira S, Noda T, Yoshimori T. Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts. J Biol Chem. 2009;284:32602-9 pubmed publisher
    A single nucleotide polymorphism in Atg16L1, an autophagy-related gene (ATG), is a risk factor for Crohn disease, a major form of chronic inflammatory bowel disease...
  3. Zhai Z, Wu F, Dong F, Chuang A, Messer J, Boone D, et al. Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p. Autophagy. 2014;10:468-79 pubmed publisher
    Multiple genetic studies have implicated the autophagy-related gene, ATG16L1, in the pathogenesis of Crohn disease (CD)...
  4. Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell. 2008;19:2916-25 pubmed publisher
    ..In this study, we showed that Golgi-resident small GTPase Rab33B (and Rab33A) specifically interacts with Atg16L, an essential factor in isolation membrane formation, in a guanosine triphosphate-dependent manner...
  5. Perricone C, Borgiani P, Romano S, Ciccacci C, Fusco G, Novelli G, et al. ATG16L1 Ala197Thr is not associated with susceptibility to Crohn's disease or with phenotype in an Italian population. Gastroenterology. 2008;134:368-70 pubmed publisher
  6. Zhang H, Qiu L, Chen Y, Zhu W, Mao C, Zhu L, et al. ATG16L1 T300A polymorphism and Crohn's disease susceptibility: evidence from 13,022 cases and 17,532 controls. Hum Genet. 2009;125:627-31 pubmed publisher
    Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn's disease (CD) susceptibility, but the results were inconclusive...
  7. Homer C, Richmond A, Rebert N, Achkar J, McDonald C. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology. 2010;139:1630-41, 1641.e1-2 pubmed publisher
    ..We examined the functional interaction between the CD risk genes ATG16L1 and NOD2 to identify an autophagy-dependent pathway that is altered by disease-associated variants...
  8. Plantinga T, Crişan T, Oosting M, van de Veerdonk F, de Jong D, Philpott D, et al. Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut. 2011;60:1229-35 pubmed publisher
    ..Genetic variation in the autophagy gene ATG16L1 has been recently implicated in Crohn's disease pathogenesis...
  9. Wildenberg M, Vos A, Wolfkamp S, Duijvestein M, Verhaar A, te Velde A, et al. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology. 2012;142:1493-503.e6 pubmed publisher
    Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease. It is not clear how autophagy is linked to loss of immune tolerance in the intestine...

More Information

Publications90

  1. Latiano A, Palmieri O, Valvano M, D Incà R, Cucchiara S, Riegler G, et al. Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy. World J Gastroenterol. 2008;14:4643-51 pubmed
    ..The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), ..
  2. Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, et al. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol. 2013;203:115-28 pubmed publisher
    ..of the LC3-ubiquitin interaction through adaptor proteins, including a direct interaction between ubiquitin and Atg16L1. To ensure that invading pathogens are captured and degraded, Atg16L1 targeting is secured by two backup systems ..
  3. Boada Romero E, Letek M, Fleischer A, Pallauf K, Ramón Barros C, Pimentel Muiños F. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. EMBO J. 2013;32:566-82 pubmed publisher
    ..Interestingly, this peptide defines a novel protein motif that mediates interaction with the WD-repeat domain of ATG16L1, thus providing a mechanistic basis for the activity...
  4. Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci. 2003;116:1679-88 pubmed
    ..region of this novel protein shows homology with yeast Apg16, we have designated it mouse Apg16-like protein (Apg16L). Apg16L, however, has a large C-terminal domain containing seven WD repeats that is absent from yeast Apg16...
  5. Roberts R, Gearry R, Hollis Moffatt J, Miller A, Reid J, Abkevich V, et al. IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. Am J Gastroenterol. 2007;102:2754-61 pubmed
    Recently, separate genome-wide association analyses have identified nonsynonymous SNPs in IL23R and ATG16L1 (rs11209026; c1142G>A, R381Q, and rs2241880; c1338A>G, T300A, respectively) as strong candidate susceptibility factors for ..
  6. Cadwell K, Liu J, Brown S, Miyoshi H, Loh J, Lennerz J, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008;456:259-63 pubmed publisher
    ..One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2)...
  7. Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, et al. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol. 2008;103:682-91 pubmed
    We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including potential interactions with other IBD genes as well as factors regulating its gene ..
  8. Weersma R, Zhernakova A, Nolte I, Lefebvre C, Rioux J, Mulder F, et al. ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. Am J Gastroenterol. 2008;103:621-7 pubmed
    ..The other, rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1), was associated with CD...
  9. Nishimura T, Kaizuka T, Cadwell K, Sahani M, Saitoh T, Akira S, et al. FIP200 regulates targeting of Atg16L1 to the isolation membrane. EMBO Rep. 2013;14:284-91 pubmed publisher
    ..Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner...
  10. Weersma R, Stokkers P, Cleynen I, Wolfkamp S, Henckaerts L, Schreiber S, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-8 pubmed publisher
    ..moderate or strong association in the WTCCC study, along with SNPs in the previously identified genes IL23R, ATG16L1, and NELL1, were studied. We confirmed the associations with IL23R (rs11209026, P=2...
  11. Ravikumar B, Moreau K, Jahreiss L, Puri C, Rubinsztein D. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol. 2010;12:747-57 pubmed publisher
    ..Here we show in mammalian cells that the heavy chain of clathrin interacts with Atg16L1 and is involved in the formation of Atg16L1-positive early autophagosome precursors...
  12. Csongei V, Jaromi L, Safrany E, Sipeky C, Magyari L, Farago B, et al. Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients. World J Gastroenterol. 2010;16:176-83 pubmed
    ..the interaction of interleukin-23 receptor (IL23R) (rs1004819 and rs2201841), autophagy-related 16-like 1 (ATG16L1) (rs2241880), caspase recruitment domain-containing protein 15 (CARD15) genes, and IBD5 locus in Crohn's disease (..
  13. Ver Heul A, Fowler C, Ramaswamy S, Piper R. Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2. J Biol Chem. 2013;288:6890-902 pubmed publisher
    ..binding its downstream targets receptor-interacting protein kinase 2 (RIP2) and autophagy-related protein 16-1 (ATG16L1)...
  14. Lu C, Chen J, Xu H, Zhou X, He Q, Li Y, et al. MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy. Gastroenterology. 2014;146:188-99 pubmed publisher
    ..and bacterial clearance in human cell lines and the correlation between MIR106B and autophagy-related gene 16L1 (ATG16L1) expression in tissues from patients with CD...
  15. Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207-11 pubmed
    ..Disease association of rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1) was replicated in these samples (P = 4.0 x 10(-8)) and confirmed in a UK case-control sample (P = 0.0004)...
  16. Sventoraityte J, Zvirbliene A, Franke A, Kwiatkowski R, Kiudelis G, Kupcinskas L, et al. NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease. World J Gastroenterol. 2010;16:359-64 pubmed
    To investigate the frequency of NOD2, IL23R and ATG16L1 genetic variants in a case-control panel for inflammatory bowel disease (IBD) from Lithuania...
  17. Gammoh N, Florey O, Overholtzer M, Jiang X. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol. 2013;20:144-9 pubmed publisher
    ..Here we have identified an interaction between mammalian FIP200 and ATG16L1, essential components of the ULK1 and ATG5 complexes, respectively...
  18. Zheng H, Ji C, Li J, Jiang H, Ren M, Lu Q, et al. Cloning and analysis of human Apg16L. DNA Seq. 2004;15:303-5 pubmed
    ..encoding a putative protein with 607 amino acid residues, which shows 90% identity and 93% similarity to mouse Apg16L. This protein, designated human Apg16L, contains a coiled-coil domain and a motif with seven WD repeats, which are ..
  19. Travassos L, Carneiro L, Ramjeet M, Hussey S, Kim Y, Magalhaes J, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010;11:55-62 pubmed publisher
    ..independent of the adaptor RIP2 and transcription factor NF-kappaB, Nod1 and Nod2 recruited the autophagy protein ATG16L1 to the plasma membrane at the bacterial entry site...
  20. Rioux J, Xavier R, Taylor K, Silverberg M, Goyette P, Huett A, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007;39:596-604 pubmed
    ..1 and a coding variant in ATG16L1, the latter of which was also recently reported by another group...
  21. Cummings J, Cooney R, Pathan S, Anderson C, Barrett J, Beckly J, et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis. 2007;13:941-6 pubmed
    A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene...
  22. Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet. 2007;52:575-83 pubmed
    ..positive association of CD with the variants in interleukin 23 receptor (IL23R), autophagy-related 16-like 1 (ATG16L1) genes and chromosome 5p13...
  23. Weersma R, Stokkers P, van Bodegraven A, Van Hogezand R, Verspaget H, de Jong D, et al. Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut. 2009;58:388-95 pubmed publisher
    ..NOD2), the IBD5 locus, the Drosophila discs large homologue 5 and autophagy-related 16-like 1 genes (DLG5 and ATG16L1) and the interleukin 23 receptor gene (IL23R)...
  24. Wilson M, Dooley H, Tooze S. WIPI2b and Atg16L1: setting the stage for autophagosome formation. Biochem Soc Trans. 2014;42:1327-34 pubmed publisher
    ..discovery of the direct interaction between the PtdIns3P effector WIPI2b and autophagy-related protein 16-like 1 (Atg16L1), a component of the LC3-conjugation complex...
  25. Nicoli E, Dumitrescu T, Uscatu C, Popescu F, Streaţă I, Serban Şoşoi S, et al. Determination of autophagy gene ATG16L1 polymorphism in human colorectal cancer. Rom J Morphol Embryol. 2014;55:57-62 pubmed
    ..In this study, we aimed to determine if ATG16L1 +898A>G (Thr300Ala) polymorphism is associated with an increased risk of developing colorectal cancer (CRC) ..
  26. Dema B, Fernandez Arquero M, Maluenda C, Polanco I, Figueredo M, De la Concha E, et al. Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease. Hum Immunol. 2009;70:946-9 pubmed publisher
    ..Based on this idea, NKX2-3, ATG16L1, and IRGM which are well-established inflammatory bowel disease risk factors, could be new celiac disease (CD) ..
  27. Lopes F, Keita Ã, Saxena A, Reyes J, Mancini N, Al Rajabi A, et al. ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction. J Biol Chem. 2018;293:3073-3087 pubmed publisher
    ..Of note, epithelia with a Crohn's disease-susceptibility mutation in the autophagy gene ATG16L1 exhibited less xenophagy...
  28. Girardelli M, Basaldella F, Paolera S, Vuch J, Tommasini A, Martelossi S, et al. Genetic profile of patients with early onset inflammatory bowel disease. Gene. 2018;645:18-29 pubmed publisher
    ..We performed direct gene sequencing looking for 94 variations in NOD2, ATG16L1, IL23R, IL10R, IL10 and XIAP genes previously shown as correlated with IBD both in multifactorial and in ..
  29. Tang J, Hsi E, Huang Y, Hsu N, Yang W, Chang H, et al. Overexpression of autophagy-related 16-like 1 in patients with oral squamous cell carcinoma. Pathol Oncol Res. 2015;21:301-5 pubmed publisher
    ..The objective of this study was to link expression of autophagy-related 16-like 1 (ATG16L1), a protein essential for autophagosome formation, to clinical outcome in a cohort of 90 OSCC patients...
  30. Wang L, Huang J, Pang S, Qin X, Qi Z, Hawley R, et al. Genetic analysis of the ATG16L1 gene promoter in sporadic Parkinson's disease. Neurosci Lett. 2017;646:30-35 pubmed publisher
    ..In this study, we further genetically and functionally analyzed the promoter of the ATG16L1 gene, a critical gene for autophagosome formation, in groups of sporadic PD patients and ethnic-matched healthy ..
  31. Cooney R, Cummings J, Pathan S, Beckly J, Geremia A, Hancock L, et al. Association between genetic variants in myosin IXB and Crohn's disease. Inflamm Bowel Dis. 2009;15:1014-21 pubmed publisher
    ..We also investigated subphenotype association and interactions with CARD15, IL23R, ATG16L1, and the IBD5 risk haplotype...
  32. Wang L, Liu L, Qin L, Luo Q, Zhang Z. Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant. Sci China Life Sci. 2017;60:333-344 pubmed publisher
    ..sequestered by autophagosomes, which was characterized by colocalization with the autophagosome precursor marker ATG16L1, the omegasome marker DFCP1, and the late autophagosomal marker LC3/GATE-16...
  33. Litwinoff E, Gold M, Singh K, Hu J, Li H, Cadwell K, et al. Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet. Obes Res Clin Pract. 2018;12:174-186 pubmed publisher
    ..Deficiency of autophagy protein ATG16L1 is associated with increases in inflammatory diseases and lipid metabolism, but the connection between ATG16L1, ..
  34. Zheng M, Yu H, Zhang L, Li H, Liu Y, Kijlstra A, et al. Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population. Invest Ophthalmol Vis Sci. 2015;56:8280-7 pubmed publisher
    ..Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-..
  35. Boutimah F, Eekels J, Liu Y, Berkhout B. Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors. Antiviral Res. 2013;98:121-9 pubmed publisher
    ..These results support the idea to validate the therapeutic potential of this anti-HIV approach in appropriate in vivo models...
  36. Corcelle Termeau E, Vindeløv S, Hämälistö S, Mograbi B, Keldsbo A, Bräsen J, et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy. 2016;12:833-49 pubmed publisher
    ..The immature autophagic membranes are rich in WIPI2, ATG16L1 and MAP1LC3B but display reduced association with ATG9A...
  37. Zherebiatiev A, Kamyshny A. Expression of aryl hydrocarbon receptor and ATG16L1 protein in experimental oxazolone-induced colitis in rats. Fiziol Zh. 2015;61:57-64 pubmed
    We studied the expression of AhR and ATG16L1 protein in experimental oxazolone-induced colitis in rats and anti-inflammatory action of recombinant antagonist of IL-1 receptors (ARIL-1) and simvastatin...
  38. Cleret Buhot A, Zhang Y, Planas D, Goulet J, Monteiro P, Gosselin A, et al. Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach. Retrovirology. 2015;12:102 pubmed publisher
    ..Database revealed a set of Th17-specific HIV dependency factors (HDFs): PARG, PAK2, KLF2, ITGB7, PTEN, ATG16L1, Alix/AIP1/PDCD6IP, LGALS3, JAK1, TRIM8, MALT1, FOXO3, ARNTL/BMAL1, ABCB1/MDR1, TNFSF13B/BAFF, and CDKN1B...
  39. Jones S, Cunningham D, Rappoport J, Heath J. The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome. J Cell Sci. 2014;127:994-1006 pubmed publisher
    ..In this report, we investigate the role of Ack1 in EGFR trafficking and show that Ack1 partially colocalises to Atg16L-positive structures upon stimulation with EGF...
  40. Jiang T, Qin B, He J, Lin S, Ding S. Three isoforms of the Atg16L1 protein contribute different autophagic properties. Mol Cell Biochem. 2013;378:257-66 pubmed publisher
    The mammalian Atg16L1 protein consists of a coiled-coil domain and a tryptophan-aspartic acid (WD) repeat domain and is involved in the process of autophagy...
  41. Prescott N, Fisher S, Franke A, Hampe J, Onnie C, Soars D, et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology. 2007;132:1665-71 pubmed
    ..identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K...
  42. Lauriola M, Ugolini G, Rivetti S, Nanì S, Rosati G, Zanotti S, et al. IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes. Int J Mol Med. 2011;27:469-77 pubmed publisher
    ..domain containing 2 caspase-activation recruitment domain 15 (NOD2/CARD15), autophagy related 16-like 1 (ATG16L1) and paired-like homeobox 2b (PHOX2B) as susceptibility loci for Crohn's Disease (CD)...
  43. Kimura T, Jain A, Choi S, Mandell M, Johansen T, Deretic V. TRIM-directed selective autophagy regulates immune activation. Autophagy. 2017;13:989-990 pubmed publisher
    ..only as receptors but also recruit and organize key components of autophagic machinery consisting of ULK1, BECN1, ATG16L1, and mammalian homologs of Atg8, with a preference for GABARAP...
  44. Döring T, Zeyen L, Bartusch C, Prange R. Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation. J Virol. 2018;92: pubmed publisher
    ..RNA interference-mediated silencing of Atg5, Atg12, and Atg16L1, which promote autophagophore expansion and LC3 membrane conjugation, interfered with viral core/nucleocapsid (NC)..
  45. Yuan J, Zhang N, Yin L, Zhu H, Zhang L, Zhou L, et al. Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib. Sci Rep. 2017;7:17814 pubmed publisher
    ..We found that ATG10 rs10036653, ATG12 rs26538, ATG16L1 rs2241880 and ATG16L2 rs11235604 were significantly associated with survival of lung adenocarcinoma patients (all ..
  46. Massey D, Parkes M. Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy. 2007;3:649-51 pubmed
    ..Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway...
  47. Pranculiene G, Steponaitiene R, Skieceviciene J, Kucinskiene R, Kiudelis G, Adamonis K, et al. Associations between NOD2, IRGM and ORMDL3 polymorphisms and pediatric-onset inflammatory bowel disease in the Lithuanian population. Medicina (Kaunas). 2016;52:325-330 pubmed publisher
    ..The aim of this study was to assess the association between NOD2, IL23R, ATG16L1, IRGM, IL10, NKX2-3 and ORMDL3 variants and early-onset IBD...
  48. Grimm W, Messer J, Murphy S, Nero T, Lodolce J, Weber C, et al. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2016;65:456-64 pubmed publisher
    b>ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria...
  49. Nagy P, Szatmári Z, Sándor G, Lippai M, Hegedus K, Juhasz G. Drosophila Atg16 promotes enteroendocrine cell differentiation via regulation of intestinal Slit/Robo signaling. Development. 2017;144:3990-4001 pubmed publisher
    Genetic variations of Atg16l1, Slit2 and Rab19 predispose to the development of inflammatory bowel disease (IBD), but the relationship between these mutations is unclear...
  50. Ulbricht A, Eppler F, Tapia V, van der Ven P, Hampe N, Hersch N, et al. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol. 2013;23:430-5 pubmed publisher
  51. Schaefer J, Attumi T, Opekun A, Abraham B, Hou J, Shelby H, et al. MicroRNA signatures differentiate Crohn's disease from ulcerative colitis. BMC Immunol. 2015;16:5 pubmed publisher
    ..A panel of miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC. ..
  52. Parkhouse R, Ebong I, Robinson C, Monie T. The N-terminal region of the human autophagy protein ATG16L1 contains a domain that folds into a helical structure consistent with formation of a coiled-coil. PLoS ONE. 2013;8:e76237 pubmed publisher
    ..One of the key complexes in autophagosome formation is the ATG12-ATG5-ATG16L1 complex...
  53. Levin A, Koelink P, Bloemendaal F, Vos A, D Haens G, van den Brink G, et al. Autophagy Contributes to the Induction of Anti-TNF Induced Macrophages. J Crohns Colitis. 2016;10:323-9 pubmed publisher
    ..reactions [MLR] in the presence of anti-TNF antibodies; 28 healthy donors were genotyped for rs_2241880 [ATG16L1]...
  54. Gajendran M, Loganathan P, Catinella A, Hashash J. A comprehensive review and update on Crohn's disease. Dis Mon. 2018;64:20-57 pubmed publisher
    ..with respect to CD, but thus far the strong and replicated associations have been identified with NOD2, IL23R and ATG16L1 genes...
  55. Gassler N. Paneth cells in intestinal physiology and pathophysiology. World J Gastrointest Pathophysiol. 2017;8:150-160 pubmed publisher
    ..The autophagy related 16-like 1 (ATG16L1) is a genetic risk factor and is involved in the exocytosis pathway of Paneth cells as well as a linker molecule ..
  56. Li G, Ren J, Li J. [Susceptibility genes and serum markers of intestinal fibrosis in Crohn disease]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:1326-1330 pubmed
    ..Recent studies have found the association of mutations in genes, such as NOD2, ATG16L1, CX3CR1, IL-23R and MMP3 with the fibrogenic phenotype of CD...
  57. Hu J, Li G, Qu L, Li N, Liu W, Xia D, et al. TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death. Cell Death Dis. 2016;7:e2323 pubmed publisher
    ..This notion is based on dotted EVA1A structures that colocalize with ZFYVE1, ATG9, LC3B, ATG16L1, ATG5, STX17, RAB7 and LAMP1, which represent different stages of the autophagic process...
  58. Hu J, Peter I. Evidence of expression variation and allelic imbalance in Crohn's disease susceptibility genes NOD2 and ATG16L1 in human dendritic cells. Gene. 2013;527:496-502 pubmed publisher
    ..NOD2 and ATG16L1 are among the major CD susceptibility genes implicated in impaired immune response to bacterial infection...
  59. Lacher M, Schroepf S, Ballauff A, Lohse P, Von Schweinitz D, Kappler R, et al. Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children. Acta Paediatr. 2009;98:1835-40 pubmed publisher
    Genome-wide association studies have described an association of the ATG16L1 (autophagy 16-like 1) gene rs2241880 variant with Crohn's disease (CD)...
  60. Wolfkamp S, Verseyden C, Vogels E, Meisner S, Boonstra K, Peters C, et al. ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients. World J Gastroenterol. 2014;20:2664-72 pubmed publisher
    ..As both autophagy related like 1 (ATG16L1) and immunity-related guanosine triphosphatase gene are autophagy genes associated with CD and more recently ..
  61. Raju D, Hussey S, Jones N. Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans. Autophagy. 2012;8:1387-8 pubmed publisher
    ..We also determined that the Crohn disease susceptibility polymorphism in the essential autophagy gene ATG16L1 increases susceptibility to H. pylori infection...
  62. Julia A, Domenech E, Ricart E, Tortosa R, Garcia Sanchez V, Gisbert J, et al. A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. Gut. 2013;62:1440-5 pubmed publisher
    ..This study demonstrates that using populations of different ancestry is a useful strategy to identify new risk loci for CD. ..
  63. Savva A, Plantinga T, Kotanidou A, Farcas M, Baziaka F, Raftogiannis M, et al. Association of autophagy-related 16-like 1 (ATG16L1) gene polymorphism with sepsis severity in patients with sepsis and ventilator-associated pneumonia. Eur J Clin Microbiol Infect Dis. 2014;33:1609-14 pubmed publisher
    ..Mechanically ventilated patients with VAP were studied. Genotyping for autophagy-related 16-like 1 (ATG16L1, rs2241880) functional polymorphism was performed using the TaqMan single-nucleotide assay...
  64. Chen R, Li X, He B, Hu W. MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma. Mol Med Rep. 2017;15:1326-1334 pubmed publisher
    ..Target prediction algorithms (TargetScan and miRanda) indicated that autophagy related 16?like 1 (ATG16L1) was a potential target gene of miR?410...
  65. Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, et al. Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. J Lipid Res. 2016;57:1006-16 pubmed publisher
    ..Cell culture study showed that UA enhanced autophagy of macrophages by increasing the expression of Atg5 and Atg16l1, which led to altered macrophage function...
  66. Dalton J, Desmond A, Shanahan F, Hill C. Detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is unrelated to the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B). Med Microbiol Immunol. 2014;203:195-205 pubmed publisher
    ..colitis (UC, n = 65) patients and healthy controls (n = 55) were examined for the presence of MAP and SNPs in ATG16L1, IL12B, NOD2/CARD15, NKx2-3, IL23R and IRGM...
  67. Yue C, Yang X, Li J, Chen X, Zhao X, Chen Y, et al. Trimethylamine N-oxide prime NLRP3 inflammasome via inhibiting ATG16L1-induced autophagy in colonic epithelial cells. Biochem Biophys Res Commun. 2017;490:541-551 pubmed publisher
    ..b>ATG16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation ..
  68. Buckingham E, Jarosinski K, Jackson W, Carpenter J, Grose C. Exocytosis of Varicella-Zoster Virus Virions Involves a Convergence of Endosomal and Autophagy Pathways. J Virol. 2016;90:8673-85 pubmed publisher
    ..This hypothesis depended on known similarities between VZV gE and autophagy-related (Atg) Atg9/Atg16L1 trafficking pathways. Investigations were carried out with highly purified fractions of VZV virions...
  69. Wang I, Sun K, Tsai T, Chen C, Chang S, Yu T, et al. MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury. Life Sci. 2015;136:133-41 pubmed publisher
    ..Human kidney proximal tubular (HK-2) cells were exposed to in vitro hypoxic conditions. ATG16L1 is essential for autophagosome formation...
  70. Sadaghian Sadabad M, Regeling A, de Goffau M, Blokzijl T, Weersma R, Penders J, et al. The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients. Gut. 2015;64:1546-52 pubmed publisher
    Crohn's disease (CD) is caused by a complex interplay among genetic, microbial and environmental factors. ATG16L1 is an important genetic factor involved in innate immunity, including autophagy and phagocytosis of microbial components ..
  71. Lee J, Essers J, Kugathasan S, Escher J, Lettre G, Butler J, et al. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet. 2010;74:489-97 pubmed publisher
    ..1 intergenic region (rs10761659) and ATG16L1 (rs10210302), in growth-impaired CD children (OR = 2.36, CI [1.26-4.41] p = 0.0056 and OR = 2.45, CI [1.22-4...
  72. Glas J, Seiderer J, Markus C, Pfennig S, Wetzke M, Paschos E, et al. Role of PPARG gene variants in inflammatory bowel disease. Inflamm Bowel Dis. 2011;17:1057-8 pubmed publisher
  73. Chu H, Khosravi A, Kusumawardhani I, Kwon A, Vasconcelos A, Cunha L, et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016;352:1116-20 pubmed publisher
    ..We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis...
  74. Kuballa P, Huett A, Rioux J, Daly M, Xavier R. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE. 2008;3:e3391 pubmed publisher
    ..A single common coding variant in the autophagy protein ATG16L1 predisposes individuals to the development of Crohn's disease: while ATG16L1 encoding threonine at amino acid ..
  75. Delgado M, Singh S, de Haro S, Master S, Ponpuak M, Dinkins C, et al. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev. 2009;227:189-202 pubmed publisher
  76. Cao B, Parnell L, Diamond M, Mysorekar I. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med. 2017;214:2303-2313 pubmed publisher
    ..Furthermore, deficiency in an essential autophagy gene, Atg16l1, in mice limited ZIKV vertical transmission and placental and fetal damage and overall improved placental and ..
  77. Begun J, Lassen K, Jijon H, Baxt L, Goel G, Heath R, et al. Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Cell Rep. 2015;11:1905-18 pubmed publisher
    The polymorphism ATG16L1 T300A, associated with increased risk of Crohn's disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown...
  78. Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz P, Tilly P, et al. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017;114:E9308-E9317 pubmed publisher
    ..Remarkably, all seven genes showed corpus callosum defects, including thicker (Atg16l1, Coro1c, Dmxl2, and Herc1), thinner (Kif21b and Wdr89), or absent corpus ..
  79. Grant S, Baldassano R, Hakonarson H. Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene. Expert Rev Mol Diagn. 2008;8:199-207 pubmed publisher
    ..associated variants have been in the CARD15, the interleukin 23 receptor (IL23R) and autophagy-related 16-like 1 (ATG16L1) genes...
  80. Yang S, Park M, Lim J, Park S, Ye B, Lee I, et al. Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans. Inflamm Bowel Dis. 2009;15:1385-90 pubmed publisher
    Recent genome-wide association studies in Caucasian populations identified IL23R and ATG16L1 as susceptibility genes to Crohn's disease (CD)...
  81. Wang H, Liu C, Mei X, Cao Y, Guo Z, Yuan Y, et al. Berberine attenuated pro-inflammatory factors and protect against neuronal damage via triggering oligodendrocyte autophagy in spinal cord injury. Oncotarget. 2017;8:98312-98321 pubmed publisher
    ..recovery, cytokines of pro-inflammatory factors (TNF-? and IL-1?), autophagy-related proteins (LC3B, ATG16L, ATG7), and apoptosis-related protein cleaved caspase-3 were determined...