Gene Symbol: ATF7
Description: activating transcription factor 7
Alias: ATFA, cyclic AMP-dependent transcription factor ATF-7, transcription factor ATF-A
Species: human
Products:     ATF7

Top Publications

  1. Diring J, Camuzeaux B, Donzeau M, Vigneron M, Rosa Calatrava M, Kedinger C, et al. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity. PLoS ONE. 2011;6:e23351 pubmed publisher
    ..The nuclear ATF7 and ATF2 (activating transcription factor) are structurally homologous leucine zipper transcription factors encoded ..
  2. Goetz J, Chatton B, Mattei M, Kedinger C. Structure and expression of the ATFa gene. J Biol Chem. 1996;271:29589-98 pubmed
    The human ATFa proteins belong to the ATF/CREB family of transcription factors. We have previously shown that they mediate the transcriptional activation by the largest E1a protein and can heterodimerize with members of the Jun/Fos family...
  3. De Graeve F, Bahr A, Sabapathy K, Hauss C, Wagner E, Kedinger C, et al. Role of the ATFa/JNK2 complex in Jun activation. Oncogene. 1999;18:3491-500 pubmed
    The ATFa proteins, which are members of the CREB/ATF family of transcription factors, display quite versatile properties...
  4. Camuzeaux B, Diring J, Hamard P, Oulad Abdelghani M, Donzeau M, Vigneron M, et al. p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive. J Mol Biol. 2008;384:980-91 pubmed publisher
    ..b>ATF7 is homologous to ATF2 and heterodimerizes with Jun or Fos proteins, modulating their DNA-binding specificities...
  5. Hamard P, Boyer Guittaut M, Camuzeaux B, Dujardin D, Hauss C, OELGESCHLAGER T, et al. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Nucleic Acids Res. 2007;35:1134-44 pubmed
    ..We identified a consensus sumoylation motif (IKEE), located within the N-terminal activation domain of the ATF7 transcription factor and thus investigated the role of this modification...
  6. Gaire M, Chatton B, Kedinger C. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. Nucleic Acids Res. 1990;18:3467-73 pubmed
    ..ATF-a and ATF-a delta therefore represent two closely related members of a larger multigene family of proteins that interact with conserved promoter elements. ..
  7. Bocco J, Bahr A, Goetz J, Hauss C, Kallunki T, Kedinger C, et al. In vivo association of ATFa with JNK/SAP kinase activities. Oncogene. 1996;12:1971-80 pubmed
    The human ATFa proteins belong to the CREB/ATF family of transcription factors. We have previously shown that the ATFa proteins may contribute to the modulation of the transcriptional activity of the Jun/Fos complexes (Chatton et al...
  8. Hamard P, Dalbies Tran R, Hauss C, Davidson I, Kedinger C, Chatton B. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. Oncogene. 2005;24:3472-83 pubmed
    The ATF7 proteins, which are members of the cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors, display quite versatile properties: they can interact with the adenovirus E1a ..
  9. Newman J, Keating A. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science. 2003;300:2097-101 pubmed
    ..Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response. ..

More Information


  1. Barchanska H, Rola R, Szczepankiewicz W, Mrachacz M. LC-MS/MS study of the degradation processes of nitisinone and its by-products. J Pharm Biomed Anal. 2019;171:15-21 pubmed publisher the human stomach, two major products of NTBC degradation are formed: 2-amino-4-(trifluoromethyl)benzoic acid (ATFA) and 2-nitro-4-(trifluoromethyl)benzoic acid (NTFA), which show considerable stability under studied conditions...
  2. Liu Y, Maekawa T, Yoshida K, Muratani M, Chatton B, Ishii S. The Transcription Factor ATF7 Controls Adipocyte Differentiation and Thermogenic Gene Programming. iScience. 2019;13:98-112 pubmed publisher
    ..Activating transcription factor 7 (ATF7), a stress-responsive chromatin regulator, is involved in energy metabolism, but the underlying mechanisms remain ..
  3. Siebert L, Staton M, Headrick S, Lewis M, Gillespie B, Young C, et al. Genome-wide association study identifies loci associated with milk leukocyte phenotypes following experimental challenge with Streptococcus uberis. Immunogenetics. 2018;70:553-562 pubmed publisher
    ..Several have been recognized in relation to infectious processes (ATF7, SGK1, and PACRG), but others less so (TRIO, GLRA1, CELSR2, TIAM2, CPE)...
  4. Hagiwara D, Suzuki S, Kamei K, Gonoi T, Kawamoto S. The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus. Fungal Genet Biol. 2014;73:138-49 pubmed publisher
    ..the mechanism underlying the long-term viability of conidia, we characterized a bZip transcription factor, AtfA, with special reference to stress-tolerance in conidia...
  5. Jaimes Arroyo R, Lara Rojas F, Bayram Ö, Valerius O, Braus G, Aguirre J. The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans. Eukaryot Cell. 2015;14:495-510 pubmed publisher
    ..In Aspergillus nidulans, the MAPK SakA and the transcription factor AtfA are components of a central multiple stress-signaling pathway that also regulates development...
  6. Chen W, Yeap Y, Bogoyevitch M. The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues. Biochem Biophys Res Commun. 2014;453:576-81 pubmed publisher
    ..evaluation in the yeast two-hybrid system defined the interacting partners as either JNK1-specific interactors (ATF7, FUS, KCNE4, PIAS1, SHANK1, TKT), typical JBD-dependent interactors shared by JNK1α1 and JNK3α1 (AKAP6, BMPR2,..
  7. Bout Tabaku S, Shults J, Zemel B, Leonard M, Berkowitz R, Stettler N, et al. Obesity is associated with greater valgus knee alignment in pubertal children, and higher body mass index is associated with greater variability in knee alignment in girls. J Rheumatol. 2015;42:126-33 pubmed publisher
    ..Knee alignment [metaphyseal-diaphyseal angle (MDA) and anterior tibiofemoral angle (ATFA)] and fat mass were measured using whole body dual-energy X-ray absorptiometry (DEXA)...
  8. Hagiwara D, Takahashi H, Kusuya Y, Kawamoto S, Kamei K, Gonoi T. Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy. BMC Genomics. 2016;17:358 pubmed publisher
    ..fumigatus 63 % of the common conidia-associated genes were expressed in a bZIP-type transcriptional regulator AtfA-dependent manner, indicating that AtfA plays a pivotal role in the maintenance of resting conidial physiology...
  9. Schlégl Ã, Szuper K, Somoskeöy S, Than P. Three dimensional radiological imaging of normal lower-limb alignment in children. Int Orthop. 2015;39:2073-80 pubmed publisher
    ..and the femoral mechanical axis-femoral shaft angle (FM-FS) and calculated the anatomical tibiofemoral angle (aTFA) from previous parameters...
  10. van Nuland Y, Eggink G, Weusthuis R. Combination of ester biosynthesis and ?-oxidation for production of mono-ethyl dicarboxylic acids and di-ethyl esters in a whole-cell biocatalytic setup with Escherichia coli. Microb Cell Fact. 2017;16:185 pubmed publisher
    ..Ethyl ester production was achieved by applying acyl-CoA ligase AlkK and an alcohol acyltransferase, either AtfA or Eeb1. E...
  11. Kröger C, Kary S, Schauer K, Cameron A. Genetic Regulation of Virulence and Antibiotic Resistance in Acinetobacter baumannii. Genes (Basel). 2016;8: pubmed publisher
    ..Quorum sensing, nucleoid-associated proteins, and non-classical transcription factors such as AtfA and small regulatory RNAs are discussed in the context of virulence and antibiotic resistance.
  12. Röttig A, Zurek P, Steinbüchel A. Assessment of bacterial acyltransferases for an efficient lipid production in metabolically engineered strains of E. coli. Metab Eng. 2015;32:195-206 pubmed publisher
    ..We genetically engineered E. coli by expressing fadD, fadR, pgpB, plsB and 'tesA in combination with atfA from Acinetobacter baylyi...
  13. Yoshida K, Maekawa T, Zhu Y, Renard Guillet C, Chatton B, Inoue K, et al. The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory. Nat Immunol. 2015;16:1034-43 pubmed publisher
    ..Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory...
  14. Emri T, Szarvas V, Orosz E, Antal K, Park H, Han K, et al. Core oxidative stress response in Aspergillus nidulans. BMC Genomics. 2015;16:478 pubmed publisher
    The b-Zip transcription factor AtfA plays a key role in regulating stress responses in the filamentous fungus Aspergillus nidulans...
  15. Sweeney K, Shi W, Gottschalk M, Kappa J, Bruce R, Fletcher N. Radiographic Assessment of Guided Growth: The Correlation Between Screw Divergence and Change in Anatomic Alignment. J Pediatr Orthop. 2017;37:e261-e264 pubmed publisher
    ..alignment of the femur, using anatomic lateral distal femoral angle (aLDFA) and anatomic femoral-tibial angle (aTFA), and intraoperative divergence of hemiepiphysiodesis screws were compared with postoperative imaging...
  16. Jamali A, Meehan J, Moroski N, Anderson M, Lamba R, Parise C. Do small changes in rotation affect measurements of lower extremity limb alignment?. J Orthop Surg Res. 2017;12:77 pubmed publisher
    ..5?±?2.9° while males had a more varus alignment with a mTFA of -1.7?±?2.9°. The anatomic tibiofemoral angle (aTFA) was 4.8?±?2.6°, the anatomic lateral distal femoral angle (aLDFA) measured 80.2?±?2...
  17. Liu B, Maekawa T, Chatton B, Ishii S. In utero TNF-? treatment induces telomere shortening in young adult mice in an ATF7-dependent manner. FEBS Open Bio. 2016;6:56-63 pubmed publisher
    ..Telomere shortening was not observed in mice lacking the stress-responsive transcription factor ATF7, which contributes to heterochromatin formation in the absence of stress...
  18. Röttig A, Strittmatter C, Schauer J, Hiessl S, Poehlein A, Daniel R, et al. Role of Wax Ester Synthase/Acyl Coenzyme A:Diacylglycerol Acyltransferase in Oleaginous Streptomyces sp. Strain G25. Appl Environ Microbiol. 2016;82:5969-81 pubmed publisher
    ..This acyltransferase exhibits 24% amino acid identity to the model enzyme AtfA from Acinetobacter baylyi but has high sequence similarities to WS/DGATs from other Streptomyces species...
  19. Schaeffer E, Vigneron M, Sibler A, Oulad Abdelghani M, Chatton B, Donzeau M. ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression. Cell Cycle. 2015;14:2655-66 pubmed publisher
    The transcription factor ATF7 undergoes multiple post-translational modifications, each of which has distinct effects upon ATF7 function...
  20. Teramachi J, Hiruma Y, Ishizuka S, Ishizuka H, Brown J, Michou L, et al. Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease. J Bone Miner Res. 2013;28:1489-500 pubmed publisher
    ..TAF12 directly interacts with the cyclic adenosine monophosphate-dependent activating transcription factor 7 (ATF7) and potentiates ATF7-induced transcriptional activation of ATF7-driven genes in other cell types, we determined ..
  21. Pescini R, Kaszubska W, Whelan J, DeLamarter J, Hooft van Huijsduijnen R. ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers. J Biol Chem. 1994;269:1159-65 pubmed
    ..Taken together, our results suggest that ATF-a0 is an important member of the ATF family with a negative regulatory role in transactivation. ..
  22. Juilland M, Gonzalez M, Erdmann T, Banz Y, Jevnikar Z, Hailfinger S, et al. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Blood. 2016;127:1780-9 pubmed publisher
    ..formed heterodimeric complexes with the AP-1 family members activating transcription factor (ATF) 2, ATF3, and ATF7. Inhibition of these complexes by a dominant-negative approach led to impaired growth of a majority of ABC DLBCL ..
  23. Werner S, Lee P, DeCamp M, Crowell D, Randall S, Crowell P. Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases. Cancer Lett. 2003;202:201-11 pubmed
    ..We conclude that PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase, and this process may be dependent on the down regulation of the cyclin dependent kinase inhibitor p21(Cip1/Waf1). ..
  24. Liu Y, Maekawa T, Yoshida K, Furuse T, Kaneda H, Wakana S, et al. ATF7 ablation prevents diet-induced obesity and insulin resistance. Biochem Biophys Res Commun. 2016;478:696-702 pubmed publisher
    ..b>ATF7 is a member of the ATF2 family, and mediates epigenetic changes induced by environmental stresses, such as social ..
  25. Hasegawa H, Ishibashi K, Kubota S, Yamaguchi C, Yuki R, Nakajo H, et al. Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase. PLoS ONE. 2014;9:e116048 pubmed publisher
    Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases...
  26. Zhou Q, Gedrich R, Engel D. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. J Virol. 1995;69:4323-30 pubmed
    ..They further suggest that the ATF/CREB-YY1 complex serves as a target for the adenovirus 243-amino-acid E1A protein. ..
  27. Nair S, Patel D, Gonzalez F, Patel B, Singhal P, Chaudhary D. Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study. Biomed Chromatogr. 2017;: pubmed publisher
    ..1 mm, 1.8 ?m) column using gradient mobile phase, acetonitrile and 2.0 mM ammonium trifluoroacetate (ATFA) at 0 to 1.7 min (65:35, v/v) and 1.8 to 2.7 min (95:5, v/v) with 0.250 mL/min flow rate...
  28. An M, Kim C, Nam G, Kim D, Rhee S, Cho S, et al. Transcriptome analysis for UVB-induced phototoxicity in mouse retina. Environ Toxicol. 2018;33:52-62 pubmed publisher
    ..chromatin and gene expression (eg, Chd5, Jarid2, Kat6a, Smarcc2, Sumo1, Zfp84), transcription factors (eg, Asxl2, Atf7, Per1, Phox2a, Rxra), RNA processing, and neuronal genes (eg, B4gal2, Drd1, Grm5, Rnf40, Rnps1, Usp39, Wbp4)...
  29. Liu Y, Maekawa T, Yoshida K, Kaneda H, Chatton B, Wakana S, et al. The transcription factor ATF7 mediates in vitro fertilization-induced gene expression changes in mouse liver. FEBS Open Bio. 2017;7:1598-1610 pubmed publisher
    ..We tested whether the transcription factor ATF7-which mediates stress-induced changes in histone H3K9 tri- and dimethylation, typical marks of epigenetic silencing-..
  30. Hall J, McElwee M, Freedman J. Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. PLoS ONE. 2017;12:e0177432 pubmed publisher
    ..In addition, knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily ..
  31. Li H, Wicks W. Retinoblastoma protein interacts with ATF2 and JNK/p38 in stimulating the transforming growth factor-beta2 promoter. Arch Biochem Biophys. 2001;394:1-12 pubmed
    Two highly related transcription factors, ATF2 and ATFa, enhance the activity of the Transforming Growth Factor beta2 (TGF-beta2) promoter via a partial cAMP response element in transfected CHO cells...
  32. Kimura M. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. FEBS Lett. 2008;582:2833-7 pubmed publisher
    ..As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter. ..
  33. Guo H, Ye S, Huang G, Liu L, Liu O, Yang S. Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer. J Cancer Res Ther. 2015;11:319-23 pubmed publisher
    ..In our study, we investigated the clinical and prognostic role of activating transcription factor 7 (ATF7) in CRC...
  34. Nair S, Patel D, Sanyal M, Singhal P, Shrivastav P. Simultaneous analysis of glucocorticosteroid fluticasone propionate and its metabolite fluticasone propionate 17?-carboxylic acid in human plasma by UPLC-MS/MS at sub pg/mL level. J Pharm Biomed Anal. 2017;135:1-7 pubmed publisher
    ..1mm, 1.7?m) column using methanol-acetonitrile (50:50, v/v) and 2.0mM ammonium trifluroacetate (ATFA) (85:15, v/v) as the mobile phase...
  35. Newman S, Bates N, Vernimmen D, Parker M, Hurst H. Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer. Oncogene. 2000;19:490-7 pubmed
    ..and the other two are bound by a variety of bZIP factors, including CREB and ATFI, with a major complex containing ATFa/ JunD. However, by using ER mutants it is clear that repression occurs essentially off the DNA...
  36. Caceres I, El Khoury R, Bailly S, Oswald I, Puel O, Bailly J. Piperine inhibits aflatoxin B1 production in Aspergillus flavus by modulating fungal oxidative stress response. Fungal Genet Biol. 2017;107:77-85 pubmed publisher
    ..with an over-expression of genes coding for several basic leucine zipper (bZIP) transcription factors such as atfA, atfB and ap-1 and genes belonging to superoxide dismutase and catalase's families...
  37. Yu P, Chen X, Li P. Enhancing microbial production of biofuels by expanding microbial metabolic pathways. Biotechnol Appl Biochem. 2017;64:606-619 pubmed publisher
    ..By introducing three genes, atfA, adhE, and pdc, into Escherichia coli to expand fatty acid pathway, up to 1...
  38. Peters C, Liang X, Li S, Kannan S, Peng Y, Taub R, et al. ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase. J Biol Chem. 2001;276:13718-26 pubmed
  39. Yin Y, Seifert A, Chua J, Maure J, Golebiowski F, Hay R. SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev. 2012;26:1196-208 pubmed publisher
    ..Thus, RNF4 is a novel DNA damage-responsive protein that plays a role in homologous recombination and integrates SUMO modification and ubiquitin signaling in the cellular response to genotoxic stress. ..