ATF6B

Summary

Gene Symbol: ATF6B
Description: activating transcription factor 6 beta
Alias: CREB-RP, CREBL1, G13, cyclic AMP-dependent transcription factor ATF-6 beta, Creb-related protein, cAMP response element-binding protein-related protein, cAMP-dependent transcription factor ATF-6 beta, cAMP-responsive element-binding protein-like 1, protein G13
Species: human
Products:     ATF6B

Top Publications

  1. Schmitt de Andrade G, Diniz V, Datte C, Pereira G, Venturini A, Campos T, et al. Newer vs. older CAD/CAM burs: Influence of bur experience on the fatigue behavior of adhesively cemented simplified lithium-disilicate glass-ceramic restorations. J Mech Behav Biomed Mater. 2019;95:172-179 pubmed publisher
    ..G1-6 - discs obtained from the 1st to 6th milling of each bur set; G7-12 - specimens from the 7th to 12th milling; G13-18 - discs from the 13th to 18th. Discs of dentin analogue (G10, 10 mm diameter and 2...
  2. Correll R, Grimes K, Prasad V, Lynch J, Khalil H, Molkentin J. Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart. Sci Rep. 2019;9:2059 pubmed publisher
    ..Mice gene-deleted for Atf6 or Atf6b were subjected to 2 weeks of transverse aortic constriction, and each showed a significant reduction in ..
  3. Yang X, Mou Y, Wang Y, Wang J, Li Y, Kong R, et al. Design, Synthesis, and Evaluation of Monoamine Oxidase A Inhibitors⁻Indocyanine Dyes Conjugates as Targeted Antitumor Agents. Molecules. 2019;24: pubmed publisher
    ..The synthesized compounds G1G13 were evaluated in vitro for their cytotoxicity against PC-3 cells using the MTT assay, and molecular docking ..
  4. Dogan S, Shen R, Ang D, Johnson M, D Angelo S, Paik P, et al. Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res. 2012;18:6169-77 pubmed publisher
    ..We genotyped 3,026 lung adenocarcinomas for the major EGFR (exon 19 deletions and L858R) and KRAS (G12, G13) mutations and examined correlations with demographic, clinical, and smoking history data...
  5. Proroga Y, Mancusi A, Peruzy M, Carullo M, Montone A, Fulgione A, et al. Characterization of Salmonella Typhimurium and its monophasic variant 1,4, [5],12:i:- isolated from different sources. Folia Microbiol (Praha). 2019;: pubmed publisher
    ..by means of the Kirby-Bauer disk-diffusion method, and for the detection of 19 genes (four Phage Markers (g13, Sieb, eat, g8), ten prophage-related virulence genes (gipA, gtgB, nanH, gogB, grvA, sopE, sspH1, sspH2, sodC1, ..
  6. de Oliveira B, Agostini I, Baesso M, Menezes Silva R, Borges A, Navarro M, et al. Influence of external energy sources on the dynamic setting process of glass-ionomer cements. Dent Mater. 2019;35:450-456 pubmed publisher
    ..Ionofil Plus (Voco; G10), Ionostar Plus (Voco; G11), Ketac Molar easymix (3M ESPE; G12), Magic Glass R (Vigodent; G13), Maxxion R (FGM; G14), Riva Self Cure (SDI; G15), Vidrion R (SS White; G16), Vitro Fil R (Nova DFL; G17) and Vitro ..
  7. Carroll P, Muwanguzi Karugaba J, Parish T. Codon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis. BMC Res Notes. 2018;11:685 pubmed publisher
    ..under the control of one of three strong, constitutive promoters (Phsp60, PrpsA or PG13) for use in mycobacteria...
  8. Gao W, Wang Y, Xiong Y, Sun L, Wang L, Wang K, et al. Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury. Acta Biomater. 2019;85:203-217 pubmed publisher
    ..activity on TLR4 activation and its downstream cytokine production among those with a GNP core of 13 nm (P12(G13)) and 5 nm (P12(G5)) in THP-1 cell-derived macrophages...
  9. He F, Chen L, Liu Q, Wang X, Li J, Yu J. Preparative Separation of Phenylethanoid and Secoiridoid Glycosides from Ligustri Lucidi Fructus by High-Speed Counter-Current Chromatography Coupled with Ultrahigh Pressure Extraction. Molecules. 2018;23: pubmed publisher
    ..b>3), and acteoside (6), and three secoiridoid glycosides, isonuezhenide (2), nuezhenoside G13 (4), and specnuezhenide (5), have been extracted and separated by a combined method of ultrahigh ..

More Information

Publications75

  1. Li J, Dai Y, Lilljebjörn H, Shen S, Cui B, Bai L, et al. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci U S A. 2018;115:E11711-E11720 pubmed publisher
    ..N159Y), respectively; G12 with IGH-CEBPE fusion and mutations in ZEB2 (p.H1038R); and G13 and G14 with TCF3/4-HLF and NUTM1 fusions, respectively...
  2. Fang J, Imran M, Hu W, Ojcius D, Li Y, Ge Y, et al. vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation. EBioMedicine. 2018;37:428-441 pubmed publisher
    ..b>G13/R36/G47 in Lep-vWA-I and G76/Q126 in Lep-vWA-II were confirmed as the Hu-GPIbα-binding sites...
  3. Lagestad P, Steen I, Dalen T. Inevitable Relative Age Effects in Different Stages of the Selection Process among Male and Female Youth Soccer Players. Sports (Basel). 2018;6: pubmed publisher
    ..We also aimed to investigate the RAE during the three different selection stages for B13, B14 (boys), and G13, G14 (girls), and gender differences in the RAE...
  4. Ilm K, Kemmner W, Osterland M, Burock S, Koch G, Herrmann P, et al. High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients. Mol Cancer. 2015;14:38 pubmed publisher
    ..survival analyses of MACC1 expression with any of the markers KRAS mutated in codon 12 (KRAS G12) or codon 13 (KRAS G13), BRAF V600 mutation and MSI status in a retrospective study of 99 CRC patients with tumors UICC staged I, II and ..
  5. Yagi H, Tan W, Dillenburg Pilla P, Armando S, Amornphimoltham P, Simaan M, et al. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal. 2011;4:ra60 pubmed publisher
    ..Multiple complementary experimental strategies, including synthetic biology approaches, indicated that signaling-selective inhibition of the CXCR4-Gα(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells. ..
  6. Zhang L, Zhai X, Liu Y, Li J, Shan Z, Teng W. Treatment with Iodine in Pregnant Rats with Marginal Iodine Deficiency Improves Cell Migration in the Developing Brain of the Progeny. Mol Neurobiol. 2016;53:2212-21 pubmed publisher
    ..we established a marginal iodine deficiency model, and iodine supplement was performed on pre-pregnancy (PP), G13 (gestation day 13), and postnatal day 0 (P0)...
  7. Justus C, Yang L. GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway. Exp Cell Res. 2015;334:100-13 pubmed publisher
    ..Altogether our results indicate that through the G12/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling. ..
  8. Brulé C, Perzo N, Joubert J, Sainsily X, Leduc R, Castel H, et al. Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors. FASEB J. 2014;28:5148-62 pubmed publisher
    ..The activated receptor coupled to Gi1, GoA, Gq, and G13, excluding Gs, and recruited β-arrestins 1 and 2...
  9. Schuhmacher M, Kudithipudi S, Kusevic D, Weirich S, Jeltsch A. Activity and specificity of the human SUV39H2 protein lysine methyltransferase. Biochim Biophys Acta. 2015;1849:55-63 pubmed publisher
    ..on H3 comprising T6-K14, with highly specific readout of R8, S10, T11 and G12 and partial specificity at T6, A7, G13 and K14...
  10. Wu Z, Li X, Zhang Y, Tong D, Wang L, Zhao P. Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise. Front Cell Neurosci. 2018;12:122 pubmed publisher
    ..rats were exposed to 3% sevoflurane for 2 h on gestational (G) day 14, or to sequential exposure for 2 h on G13, G14 and G15...
  11. Baudouin A, Diouf E, Tall M, Duval S, Provôt S, Picaud J, et al. [Advantages and special features of hospital preparations of parenteral nutrition in neonatalogy]. Ann Pharm Fr. 2015;73:150-9 pubmed publisher
    ..formulations NP 100®, Pediaven AP-HP Nouveau-né 1®, Pediaven AP-HP Nouveau-né 2® and Numetah G13% E® and of two hospital preparations made specifically in hospital pharmacies produced by two separate ..
  12. Shahriari Z, Heidari B, Dadkhodaie A. Dissection of genotype × environment interactions for mucilage and seed yield in Plantago species: Application of AMMI and GGE biplot analyses. PLoS ONE. 2018;13:e0196095 pubmed publisher
    ..psyllium), G1, G2 and G4 (P. major), G9 and G10 (P. officinalis) and P. lanceolata were identified as stable. G13 (P. ovata), G5 and G6 (P. major) and G30 (P. lagopus) had higher stability for mucilage content...
  13. Martinetti D, Costanzo R, Kadare S, Alimehmeti M, Colarossi C, Canzonieri V, et al. KRAS and BRAF mutational status in colon cancer from Albanian patients. Diagn Pathol. 2014;9:187 pubmed publisher
    ..Out of the 159 cases, 28 (17,6%) showed KRAS mutation (13 G12D, 4 G12C, 4 G12V, 3 G12A, 2 G13 D, 1 G12S and 1 A146T), and 10 (6,3%) showed BRAF mutation (all V600E)...
  14. Sriwai W, Mahavadi S, Al Shboul O, Grider J, Murthy K. Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA. PLoS ONE. 2013;8:e66743 pubmed publisher
    ..The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated Gq, G13, Gi1, PI hydrolysis, and Rho kinase activity, and inhibited cAMP formation...
  15. Quoyer J, Janz J, Luo J, Ren Y, Armando S, Lukashova V, et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013;110:E5088-97 pubmed publisher
    ..pepducin, ATI-2341, on the ability of the receptor to engage the inhibitory G proteins (Gi1, Gi2 and Gi3), G13, and ?-arrestins...
  16. Badalamenti J, Bond D. Complete Genome of Geobacter pickeringii G13T, a Metal-Reducing Isolate from Sedimentary Kaolin Deposits. Genome Announc. 2015;3: pubmed publisher
    We used PacBio sequencing to assemble the genome of the pristine freshwater isolate Geobacter pickeringii G13(T) into a single 3,618,700-bp circular chromosome polished to 99.999% accuracy (quality value [QV], 50)...
  17. Feng X, Liu X, Lu S, Ren H, Li Y, Hu P, et al. Expression, purification and characterization of recombinant toxins consisting of truncated gastrin 17 and pseudomonas exotoxin. Protein Pept Lett. 2015;22:193-201 pubmed
    ..Four recombinant Pseudomonas toxins PE38 fused with the forward or reverse truncated forms of G17 (G14 and G13) were successfully constructed, expressed, and purified...
  18. Roland A, Ricobaraza A, Carrel D, Jordan B, Rico F, Simon A, et al. Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth. elife. 2014;3:e03159 pubmed publisher
    ..by endo- or exocannabinoids such as the marijuana component ∆(9)-tetrahydrocannabinol, to heterotrimeric G12/G13 proteins that triggers rapid and reversible non-muscle myosin II (NM II) dependent contraction of the actomyosin ..
  19. Parker J, Mattos C. The Ras-Membrane Interface: Isoform-specific Differences in The Catalytic Domain. Mol Cancer Res. 2015;13:595-603 pubmed publisher
    The small GTPase Ras is mutated in about 20% of human cancers, primarily at active site amino acid residues G12, G13, and Q61...
  20. Lecointre C, Desrues L, Joubert J, Perzo N, Guichet P, Le Joncour V, et al. Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma. Oncogene. 2015;34:5080-94 pubmed publisher
    ..These effects mainly involved the G13/Rho/rho kinase pathway while partially requiring Gi/o/PI3K components...
  21. Huang Y, Su Y, Chang C, Sun W. Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals. J Recept Signal Transduct Res. 2016;36:633-644 pubmed
    ..4 ? 6.8, are important to pH homeostasis, immune responses and acid-induced pain. Although G2A mediates the G13-Rho pathway in response to acid, whether G2A activates Gs, Gi or Gq proteins remains debated...
  22. Li Y, Tardif G, Hum D, Kapoor M, Fahmi H, Pelletier J, et al. The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target. Arthritis Res Ther. 2016;18:172 pubmed publisher
    ..The activation of ER stress sensors (phosphorylated PERK, cleavage of ATF6B, and the spliced mRNA forms of XBP1) was not significantly increased in OA chondrocytes/cartilage...
  23. Vilar M, Peralta B, García Bocanegra I, Simon Grifé M, Bensaid A, Casal J, et al. Distribution and genetic characterization of Enterovirus G and Sapelovirus A in six Spanish swine herds. Virus Res. 2016;215:42-9 pubmed publisher
    ..EV-G indicated circulation of diverse strains in the same farm, related to genotypes G1, G2, G3, G4, G6, G9, G12, G13 and G14...
  24. Wagner M, da Rosa R, de Figueiredo J, Duarte M, Pereira J, Só M. Final irrigation protocols may affect intraradicular dentin ultrastructure. Clin Oral Investig. 2017;21:2173-2182 pubmed publisher
    ..9% saline by 2.5% NaOCl; and G10 to G13 by 2% CHX. One-half of each sample was prepared and evaluated using SEM and the other one by TEM observations...
  25. Srinivasan S, Schiemer J, Zhang X, Chishti A, Le Breton G. Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets. J Biol Chem. 2015;290:25129-39 pubmed publisher
    ..Based on the limited scope of this involvement, and the known importance of G13 in hemostasis and thrombosis, the present study examined whether signaling through another switch region of G13, i...
  26. M Kadmi C, Leyris J, Onfroy L, Galés C, Saulière A, Gagne D, et al. Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling. J Biol Chem. 2015;290:27021-39 pubmed publisher
    ..GHS-R1a signals through Gq, Gi/o, G13, and arrestin...
  27. Che Y, Lu Y, Zha X, Huang H, Yang P, Ma L, et al. Higher efficiency soluble prokaryotic expression, purification, and structural analysis of antimicrobial peptide G13. Protein Expr Purif. 2016;119:45-50 pubmed publisher
    b>G13 is a 19-residue cationic antimicrobial peptide derived from granulysin...
  28. Autiero I, Ruvo M, Improta R, Vitagliano L. The intrinsic flexibility of the aptamer targeting the ribosomal protein S8 is a key factor for the molecular recognition. Biochim Biophys Acta Gen Subj. 2018;1862:1006-1016 pubmed publisher
    ..Particularly relevant is switch of the A26 base from its ligand-free state to a location that allows the G13-C28 base-pairing. Intrinsic flexibility of the aptamer is essential for partner recognition...
  29. Mandaviya P, Aïssi D, Dekkers K, Joehanes R, Kasela S, Truong V, et al. Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics. 2017;9:1403-1422 pubmed publisher
    ..8-kb spanning domain (TNXB/ATF6B) at chromosome 6...
  30. Geißler A, Geißler M, Kottmann D, Lutz L, Fichter C, Fritsch R, et al. ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer. Oncotarget. 2017;8:17164-17190 pubmed publisher
    ..In fact, EGFR-targeted treatment responses were also observed in RAS exon 2 p.G13 mutated CRC cell lines or CRC cases and were further linked to PIK3CA exon 9 mutations...
  31. Lu S, Jang H, Nussinov R, Zhang J. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B. Sci Rep. 2016;6:21949 pubmed publisher
    Ras mediates cell proliferation, survival and differentiation. Mutations in K-Ras4B are predominant at residues G12, G13 and Q61...
  32. dos Santos J, Mangolin C, Machado M, Scapim C, Giordani W, Gonçalves L. Genetic variability among elite popcorn lines based on molecular and morphoagronomic characteristics. Genet Mol Res. 2017;16: pubmed publisher
    ..The lines G3, G4, G11, and G13 exhibited favorable morphological characters and low disease incidence rates...
  33. Nikodemova M, Yee J, Carney P, Bradfield C, Malecki K. Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. Environ Int. 2018;113:249-258 pubmed publisher
    ..FTH1, TXN), two hypoxia response genes (BN1P3lL, ARNT), and one gene associated with unfolded protein response (ATF6B)...
  34. Fujii T, Barzi A, Sartore Bianchi A, Cassingena A, Siravegna G, Karp D, et al. Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers. Clin Cancer Res. 2017;23:3657-3666 pubmed publisher
    ..Design: A quantitative, mutation-enrichment next-generation sequencing test for detecting KRASG12/G13 mutations in urine cfDNA was developed, and results were compared with clinical testing of archival tumor ..
  35. Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A. Clr4 specificity and catalytic activity beyond H3K9 methylation. Biochimie. 2017;135:83-88 pubmed publisher
    ..In addition, it exhibits specific contacts at the S10, T11, G12 and G13 positions of the H3 peptide recognizing an R-K-SKRT-TCS-G sequence...
  36. Pianezze G, Toniolo M, Taddei Masieri M, Dolcini B, Ravani A. Hb Belluno [?111(G13)Val?Gly;?133(H11)Val?Val (HBB: c.335T?>?G;402G?>?C)]: Incidental Detection of a New Clinically Silent ? Chain Variant During Hb A1c Determination by High Performance Liquid Chromatography. Hemoglobin. 2016;40:143-9 pubmed publisher
    A previously unreported ? chain variant, Hb Belluno [?111(G13)Val?Gly;?133(H11)Val?Val (HBB: c.335T?>?G;402G?>?C)], was incidentally discovered in a woman suffering from diabetes, during glycated hemoglobin (Hb A1c) assay...
  37. Mathieu Y, Piumi F, Valli R, Aramburu J, Ferreira P, Faulds C, et al. Activities of Secreted Aryl Alcohol Quinone Oxidoreductases from Pycnoporus cinnabarinus Provide Insights into Fungal Degradation of Plant Biomass. Appl Environ Microbiol. 2016;82:2411-2423 pubmed publisher
    ..Here, we analyze the distribution of the other three AA3_2 enzymes (scf185002.g8, scf184611.g7, and scf184746.g13) to assess their putative functions...
  38. Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi C, et al. Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses. PLoS ONE. 2015;10:e0129334 pubmed publisher
    ..receptor (GPCR) coupling to multiple intracellular signaling pathways, including the Gs protein/cAMP and G13 protein/Rho...
  39. Hulmi J, Hentilä J, DeRuisseau K, Oliveira B, Papaioannou K, Autio R, et al. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radic Biol Med. 2016;99:308-322 pubmed publisher
    ..muscle displayed greater levels of UPR/ER-pathway indicators including greater protein levels of IRE1?, PERK and Atf6b mRNA. Downstream to IRE1? and PERK, spliced Xbp1 mRNA and phosphorylation of eIF2?, were also increased...
  40. Ma Y. Identification of G and P genotype-specific motifs in the predicted VP7 and VP4 amino acid sequences. Virus Res. 2015;210:271-8 pubmed publisher
    ..Its genotype constellations were determined as G13-P[18]-I6-R9-C9-M6-A6-N9-T12-E14-H11, confirming previous genotype assignments...
  41. Janku F, Huang H, Fujii T, Shelton D, Madwani K, Fu S, et al. Multiplex KRASG12/G13 mutation testing of unamplified cell-free DNA from the plasma of patients with advanced cancers using droplet digital polymerase chain reaction. Ann Oncol. 2017;28:642-650 pubmed publisher
    ..of unamplified plasma cfDNA from 121 patients with diverse progressing advanced cancers were tested with a KRASG12/G13 multiplex assay to detect the seven most common mutations in the hotspot of exon 2 using droplet digital polymerase ..
  42. Longest P, Hindle M. Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition. Pharm Res. 2017;34:2049-2065 pubmed publisher
    ..dissolution, absorption and clearance occurring in the surface liquid of a representative small airway generation (G13) was developed and used to evaluate epithelial dose for the same deposited drug mass of conventional microparticles,..
  43. Zhou M, Wang M, Xue L, Lin Z, He Q, Shi W, et al. A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR). J Biol Chem. 2017;292:13934-13946 pubmed publisher
    ..a highly conserved uridine at position 22 at the D-stem of tRNALeu(UUR), introducing a G-C base pairing (G13-C22) at the D-stem and a tertiary base pairing (C22-G46) between the D-stem and the variable loop...
  44. Kawamura T, Hirata A, Ohno S, Nomura Y, Nagano T, Nameki N, et al. Multisite-specific archaeosine tRNA-guanine transglycosylase (ArcTGT) from Thermoplasma acidophilum, a thermo-acidophilic archaeon. Nucleic Acids Res. 2016;44:1894-908 pubmed publisher
    ..In contrast, T. acidophilum cell extract exchanged both G13 and G15 bases. Because T...
  45. Afzal M, Shad S. Characterization of Phenacoccus solenopsis (Tinsley) (Homoptera: Pseudococcidae) Resistance to Emamectin Benzoate: Cross-Resistance Patterns and Fitness Cost Analysis. Neotrop Entomol. 2016;45:310-9 pubmed publisher
    ..decline in emamectin resistance was observed in the resistant population when not exposed to emamectin from G7 to G13. The estimated realized heritability (h (2)) for emamectin resistance was 0.84...
  46. Cai Y, Guo Y, Li Z, Wu D, Li X, Zhang H, et al. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4. Eur J Med Chem. 2016;114:134-40 pubmed publisher
    ..Here, we report the isolation and characterization of 13 compounds (G1-G13) by bioassay-guided fractionation of the ethyl acetate extraction of Gaultheria yunnanensis (FRANCH...
  47. Lim Y, Ovejero D, Derrick K, Collins M, Choate K. Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy. J Am Acad Dermatol. 2016;75:420-7 pubmed publisher
    ..Our new case harbored somatic activating HRAS p.G13 R mutation in affected tissue, consistent with previous findings...
  48. Mizuuchi M, Cindrova Davies T, Olovsson M, Charnock Jones D, Burton G, Yung H. Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complications. J Pathol. 2016;238:550-61 pubmed publisher
    ..Therefore, these results further support the targeting of placental ER stress as a potential new therapeutic intervention for these pregnancy complications. ..
  49. Ye J, Rawson R, Komuro R, Chen X, Dav U, Prywes R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000;6:1355-64 pubmed
    ..ATF6 processing did not require SCAP, which is essential for SREBP processing. We conclude that S1P and S2P are required for the ER stress response as well as for lipid synthesis...
  50. Okada T, Haze K, Nadanaka S, Yoshida H, Seidah N, Hirano Y, et al. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem. 2003;278:31024-32 pubmed
    ..These results indicate that the transport of ATF6 from the ER to the Golgi apparatus and that from the Golgi apparatus to the nucleus are distinct steps that can be distinguished by treatment with AEBSF. ..
  51. Tong W, Nagano Fujii M, Hidajat R, Deng L, Takigawa Y, Hotta H. Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta. Biochem Biophys Res Commun. 2002;299:366-72 pubmed
    ..Collectively, our results imply the possibility that NS4B modulates certain cellular responses upon ER stress through the physical interaction with CREB-RP/ATF6beta and ATF6alpha...
  52. Min J, Shukla H, Kozono H, Bronson S, Weissman S, Chaplin D. A novel Creb family gene telomeric of HLA-DRA in the HLA complex. Genomics. 1995;30:149-56 pubmed
    ..The amino acid sequence homology and general structural features of the predicted protein indicate that this gene encodes a general transcription factor belonging to the Creb/ATF subfamily of the bZip super-family. ..
  53. Khanna A, Campbell R. The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. Biochem J. 1996;319 ( Pt 1):81-9 pubmed
    b>G13 is a single-copy gene lying approx. 75 kb centromeric of the complement gene cluster in the class III region of the human MHC. The gene spans approx. 17 kb of DNA and has been shown to encode mRNA of approx. 2...
  54. Möhrmann L, Huang H, Hong D, Tsimberidou A, Fu S, Piha Paul S, et al. Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers. Clin Cancer Res. 2018;24:181-188 pubmed publisher
    ..digital PCR (ddPCR) and BEAMing PCR were used to test cfDNA for BRAFV600, KRASG12/G13, and EGFRexon19del/L858R mutations in 43 patients with progressing advanced cancers...
  55. Weidinger S, Willis Owen S, Kamatani Y, Baurecht H, Morar N, Liang L, et al. A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet. 2013;22:4841-56 pubmed publisher
    ..Our results indicate that the pathogenesis of AD incorporates immune and epidermal barrier defects with combinations of specific and overlapping effects at individual loci. ..
  56. Griewank K, Wiesner T, Murali R, Pischler C, Muller H, Koelsche C, et al. Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles. Mod Pathol. 2017;: pubmed publisher
    ..Activating RAS mutations (G12 and G13) identified in 3 pleomorphic dermal sarcoma were not found in atypical fibroxanthoma...
  57. Guan D, Wang H, Li V, Xu Y, Yang M, Shen Z. N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha. J Cell Biochem. 2009;108:825-31 pubmed publisher
    ..These results provide the first evidence that unglycosylated ATF6beta may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6alpha. ..
  58. Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, et al. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem J. 2001;355:19-28 pubmed
    ..This protein encoded by the G13 (cAMP response element binding protein-related protein) gene is constitutively synthesized as a type II ..
  59. Thuerauf D, Morrison L, Glembotski C. Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. J Biol Chem. 2004;279:21078-84 pubmed
    ..Thus, ATF6beta may serve as a transcriptional repressor functioning in part to regulate the strength and duration of ATF6alpha-mediated ERSRG activation during the ER stress response. ..
  60. Speek M, Barry F, Miller W. Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. Hum Mol Genet. 1996;5:1749-58 pubmed
    ..RACE cloning and RNase protection experiments reveal no such alternate splicing. The TN-X gene appears to be unique in having both its 5' and 3' ends buried in other genes. ..
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    ..We concluded that ATF6 homo- or heterodimers recognize and bind directly to both the DNA and adjacent protein NF-Y and that this complex formation process is essential for transcriptional induction of ER chaperones. ..
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    ..57, P = 2.73 × 10(-5) ), with an inverse association among smokers (OR = 1.42, P = 0.00228), suggesting that smoking modifies the effect of some genetic polymorphisms on AMD risk. ..
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    ..from healthy pigs were highly divergent from other known RVC strains and were provisionally classified as G12 and G13 based on the 86% nucleotide identity cut-off value...
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    ..These results suggest that, as in yeast, bZIP proteins are involved in mammalian UPR, acting through newly defined ERSE. ..
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    ..Genetic data suggest that TN-X may be essential for life. ..