ATF5

Summary

Gene Symbol: ATF5
Description: activating transcription factor 5
Alias: ATFX, HMFN0395, cyclic AMP-dependent transcription factor ATF-5, cAMP-dependent transcription factor ATF-5, transcription factor ATFx
Species: human
Products:     ATF5

Top Publications

  1. Nishizawa M, Nagata S. cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. FEBS Lett. 1992;299:36-8 pubmed
    ..Three leucine-zipper proteins were isolated from mouse cDNA expression libraries by this method: NF-IL6, ATF4, and a novel ATF4-related ATFx. The interactions of these proteins with GPE1-BP may play key roles in G-CSF gene expression.
  2. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, et al. E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Cell Signal. 2008;20:942-8 pubmed publisher
    ..Cotransfection of SIAH1 could withdraw up-regulation of TGF-beta signaling by TRB3, suggesting SIAH1-induced degradation of TRB3 represents a potential regulatory mechanism for TGF-beta signaling. ..
  3. Hatano M, Umemura M, Kimura N, Yamazaki T, Takeda H, Nakano H, et al. The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress. FEBS J. 2013;280:4693-707 pubmed publisher
    We previously reported that activating transcription factor 5 (ATF5) mRNA increases in response to amino acid limitation, and that this increase is dependent on mRNA stabilization...
  4. Zhou D, Palam L, Jiang L, Narasimhan J, Staschke K, Wek R. Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J Biol Chem. 2008;283:7064-73 pubmed publisher
    ..We show that the expression of the basic zipper transcriptional regulator ATF5 is induced in response to many different stresses, including endoplasmic reticulum stress, arsenite exposure, and ..
  5. Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, et al. Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region. J Biol Chem. 2008;283:2543-53 pubmed
    ..We previously reported that ATF5 mRNA expression increased in response to amino acid limitation...
  6. Feldheim J, Kessler A, Schmitt D, Wilczek L, Linsenmann T, Dahlmann M, et al. Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients. Onco Targets Ther. 2018;11:8673-8684 pubmed publisher
    b>ATF5 suppresses differentiation of neuroprogenitor cells and is overexpressed in glioblastoma (GBM). A reduction of its expression leads to apoptotic GBM cell death...
  7. Huang J, Jiang G, Song Q, Gu X, Hu M, Wang X, et al. Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis. Nat Commun. 2017;8:15144 pubmed publisher
    ..nanostructure that can induce cancer cells to 'drink drugs' for targeting activating transcription factor-5 (ATF5), an overexpressed anti-apoptotic transcription factor in glioblastoma...
  8. Umemura M, Tsunematsu K, Shimizu Y, Nakano H, Takahashi S, Higashiura Y, et al. Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron. Biosci Biotechnol Biochem. 2015;79:1082-9 pubmed publisher
    Activating transcription factor 5 (ATF5) is a stress response transcription factor of the cAMP-responsive element-binding/ATF family...
  9. Juliana C, Yang J, Cannon C, Good A, Haemmerle M, Stoffers D. A PDX1-ATF transcriptional complex governs β cell survival during stress. Mol Metab. 2018;17:39-48 pubmed publisher
    ..and duodenal homeobox 1 (PDX1), Activating transcription factor 4 (ATF4), and Activating transcription factor 5 (ATF5) are transcription factors implicated in β cell survival and susceptibility to stress...

More Information

Publications71

  1. Tian Y, Guo S, Chen C, Zhao L, Li Z, Yan Y. Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects. Environ Toxicol Pharmacol. 2018;64:60-69 pubmed publisher
    ..Sgk1, HCRTr1, HspB1, Rem2, Oprd1, ATF5, and TRHr identified in this study may be involved in oxidative stress mechanisms, dopamine (DA) synthesis, and ..
  2. Juliana C, Yang J, Rozo A, Good A, Groff D, Wang S, et al. ATF5 regulates β-cell survival during stress. Proc Natl Acad Sci U S A. 2017;114:1341-1346 pubmed publisher
    ..Here we show that Atf5, a close but less-studied relative of Atf4, is also a target of Pdx1 and is critical for β-cell survival under ..
  3. Koh K, Pan X, Zhang W, McLachlan A, Urrutia R, Jeong H. Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice. Mol Pharmacol. 2014;86:727-35 pubmed publisher
    ..As a result, seven transcription factors-activating transcription factor 5 (ATF5), early growth response 1 (EGR1), forkhead box protein A3 (FOXA3), JUNB, Krüppel-like factor 9 (KLF9), KLF10, ..
  4. Login H, HÃ¥glin S, Berghard A, Bohm S. The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map. J Neurosci. 2015;35:13807-18 pubmed publisher
    ..Initially, these effects are selective to the VL-most zone and correlate with reduced ATF5 expression and accumulation of OSNs that do not express ORs...
  5. Huang R, Qian D, Hu M, Zhang X, Song J, Li L, et al. Association between human cytomegalovirus infection and histone acetylation level in various histological types of glioma. Oncol Lett. 2015;10:2812-2820 pubmed
    ..The in situ protein expression of IE86, which is encoded by the IE2 gene, activating transcription factor 5 (ATF5), P300, acetyl-histone H3K9 and acetyl-histone H3K14 was detected by immunohistochemistry...
  6. York D, Sproul C, Chikere N, Dickinson P, Angelastro J. Expression and targeting of transcription factor ATF5 in dog gliomas. Vet Comp Oncol. 2018;16:102-107 pubmed publisher
    Activating transcription factor 5 (ATF5) is a transcription factor that is highly expressed in undifferentiated neural progenitor/stem cells as well as a variety of human cancers including gliomas...
  7. Karpel Massler G, Horst B, Shu C, Chau L, Tsujiuchi T, Bruce J, et al. A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers. Clin Cancer Res. 2016;22:4698-711 pubmed publisher
    ..Activating transcription factor 5 (ATF5) is upregulated in various malignancies and promotes apoptotic resistance...
  8. Figueira I, Tavares L, Jardim C, Costa I, Terrasso A, Almeida A, et al. Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study. Eur J Nutr. 2019;58:113-130 pubmed publisher
    ..Genes such as ASNS and ATF5 emerged as novel BDP-modulated targets...
  9. Rocher S, Jean M, Castonguay Y, Belzile F. Validation of Genotyping-By-Sequencing Analysis in Populations of Tetraploid Alfalfa by 454 Sequencing. PLoS ONE. 2015;10:e0131918 pubmed publisher
    ..sativa): the synthetic cultivar Apica (ATF0) and a derived population (ATF5) obtained after five cycles of recurrent selection for superior tolerance to freezing (TF)...
  10. Yuan Y, Gaither K, Kim E, Liu E, Hu M, Lengel K, et al. SUMO2/3 modification of activating transcription factor 5 (ATF5) controls its dynamic translocation at the centrosome. J Biol Chem. 2018;293:2939-2948 pubmed publisher
    Activating transcription factor 5 (ATF5) is a member of the ATF/cAMP response element-binding protein family of transcription factors...
  11. Li Y, Lan X, Wu L, DU X, Ezra K, Li D, et al. [Bidirectional regulation of Pam3CSK4?induced inflammatory response by ATP?binding cassette transporter A1 knockdown in mouse mononuclear macrophages in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1563-1569 pubmed
    ..factor 3 (ATF3) without obviously affecting the expressions of the transcription factors ATF1, ATF2, ATF4 or ATF5. ABCA1 knockdown in macrophages may have both proinflammatory and anti?inflammatory effects...
  12. Nikonorova I, Al Baghdadi R, Mirek E, Wang Y, Goudie M, Wetstein B, et al. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice. J Biol Chem. 2017;292:6786-6798 pubmed publisher
    ..hepatic PERK activation to asparaginase, yet surprisingly, mRNA levels of key ISR gene targets such as Atf5 and Trib3 failed to increase...
  13. Bisikirska B, Bansal M, Shen Y, Teruya Feldstein J, Chaganti R, Califano A. Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res. 2016;76:664-74 pubmed publisher
    ..This analysis revealed FOXM1, TFDP1, ATF5, HMGA1, and NFYB to be candidate master regulators (MR) contributing to disease progression...
  14. Wang Z, Zhou Y, Luo Y, Zhang J, Zhai Y, Yang D, et al. Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice. Int J Mol Sci. 2015;16:28320-33 pubmed publisher
    ..Tet3 were significantly up-regulated, while Olfr370, Olfr1414, Olfr1208, Golf, Faim2, Tsg101, Mapk10, Actl6b, H2BE, ATF5, Kirrrel2, OMP, Drd2 etc. were significantly down-regulated...
  15. Nakano H, Iida Y, Suzuki M, Aoki M, Umemura M, Takahashi S, et al. Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons. Cell Tissue Res. 2016;363:621-33 pubmed publisher
    Activating transcription factor 5 (ATF5) is a member of the CREB/ATF family of transcription factors, which is highly expressed in olfactory chemosensory tissues, the main olfactory epithelium and vomeronasal epithelium (VNE) in mice...
  16. Quirós P, Prado M, Zamboni N, D Amico D, Williams R, Finley D, et al. Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. J Cell Biol. 2017;216:2027-2045 pubmed publisher
    ..Surprisingly, canonical mitochondrial unfolded protein response genes mediated by ATF5 are not activated...
  17. Angelastro J. Targeting ATF5 in Cancer. Trends Cancer. 2017;3:471-474 pubmed publisher
    The expression of activating transcription factor 5 (ATF5) correlates negatively with patient survival in different types of cancer...
  18. Chuang H, Wang J, Hsieh W, Chang Y, Su I. Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders. Am J Pathol. 2008;173:1397-405 pubmed publisher
    ..In this study, using cDNA microarray analysis, we identified ATF5 as the candidate transcriptional repressor for SAP expression in LMP-1-expressing T cells...
  19. Deng P, Haynes C. Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR. Semin Cancer Biol. 2017;47:43-49 pubmed publisher
  20. Fiorese C, Schulz A, Lin Y, Rosin N, Pellegrino M, Haynes C. The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR. Curr Biol. 2016;26:2037-2043 pubmed publisher
    ..Here, we describe a mammalian transcription factor, ATF5, which is regulated similarly to ATFS-1 and induces a similar transcriptional response...
  21. Chen A, Qian D, Wang B, Hu M, Lu J, Qi Y, et al. ATF5 is overexpressed in epithelial ovarian carcinomas and interference with its function increases apoptosis through the downregulation of Bcl-2 in SKOV-3 cells. Int J Gynecol Pathol. 2012;31:532-7 pubmed publisher
    The activating transcription factor 5 (ATF5) is highly expressed in many kinds of tumors including glioblastoma and breast cancers, but its expression in epithelial ovarian neoplasms has not been investigated...
  22. Liu W, Sun M, Jiang J, Shen X, Sun Q, Liu W, et al. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. Biochem Biophys Res Commun. 2004;321:954-60 pubmed
    ..But Cyclin D1 and Cyclin D2 had no effect on hATF5 transcriptional activity. These data provide a new clue to understand the new role of Cyclin D3 as a transcriptional regulator. ..
  23. Hernández I, Torres Peraza J, Santos Galindo M, Ramos Morón E, Fernandez Fernandez M, Pérez Álvarez M, et al. The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease. Acta Neuropathol. 2017;134:839-850 pubmed publisher
    Activating transcription factor-5 (ATF5) is a stress-response transcription factor induced upon different cell stressors like fasting, amino-acid limitation, cadmium or arsenite...
  24. Dluzen D, Li G, Tacelosky D, Moreau M, Liu D. BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J Biol Chem. 2011;286:7705-13 pubmed publisher
    b>ATF5 loss of function has been shown previously to cause apoptotic cell death in glioblastoma and breast cancer cells but not in non-transformed astrocytes and human breast epithelial cells...
  25. Leong D, Abraham M, Gupta A, Lim T, Chew F, Hutmacher D. ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells. J Cell Biochem. 2012;113:2744-53 pubmed publisher
    ..From our statistical analysis, we found activating transcription factor 5 (ATF5) to be significantly and consistently down-regulated in a randomized time-course study of osteogenically ..
  26. Forgacs E, Gupta S, Kerry J, Semmes O. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. J Virol. 2005;79:6932-9 pubmed
    ..We have identified a cellular repressor of transcription, activating transcription factor x (ATFx), as a novel Tax-binding protein...
  27. Gao F, Xia Y, Wang J, Lin Z, Ou Y, Liu X, et al. Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. Genome Biol. 2014;15:533 pubmed publisher
    ..Six genes were selected as tumor suppressor gene candidates, among which, ECM1, ATF5 and EOMES are confirmed via siRNA experiments to have potential anti-cancer functions.
  28. Ishihara S, Yasuda M, Ishizu A, Ishikawa M, Shirato H, Haga H. Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells. Oncotarget. 2015;6:4602-14 pubmed
    ..Here, we show that activating transcription factor 5 (ATF5) promotes radioresistance and malignancy in cancer cells after irradiation...
  29. Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, et al. Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. Neurosci Lett. 2007;417:316-21 pubmed
    ..As interacting-proteins with DISC1, Nudel, ATF4, ATF5, LIS1, alpha-tubulin, PDE4B, eIF3, FEZ1, Kendrin, MAP1A and MIPT3 were identified...
  30. Peters C, Liang X, Li S, Kannan S, Peng Y, Taub R, et al. ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase. J Biol Chem. 2001;276:13718-26 pubmed
  31. Vesely P, Staber P, Hoefler G, Kenner L. Translational regulation mechanisms of AP-1 proteins. Mutat Res. 2009;682:7-12 pubmed publisher
    ..We conclude that in addition to transcriptional and post-translational control mechanisms translational regulation contributes to the balanced production of AP-1 proteins, in order to maintain physiological cellular conditions. ..
  32. Wei Y, Ge Y, Zhou F, Chen H, Cui C, Liu D, et al. Identification and characterization of the promoter of human ATF5 gene. J Biochem. 2010;148:171-8 pubmed publisher
    b>ATF5, a member of ATF/CREB family of b-ZIP transcription factors, is highly expressed in a wide variety of neoplasms and regulates cell differentiation, cell survival and apoptosis...
  33. Abe T, Kojima M, Akanuma S, Iwashita H, Yamazaki T, Okuyama R, et al. N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1? (IL-1?)-induced stabilization. J Biol Chem. 2014;289:3888-900 pubmed publisher
    Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2)...
  34. Yamazaki T, Ohmi A, Kurumaya H, Kato K, Abe T, Yamamoto H, et al. Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells. Life Sci. 2010;87:294-301 pubmed publisher
    ..We have shown that ATF5 is a stress response transcription factor that responds to amino acid limitation, arsenite exposure, or cadmium ..
  35. Liu D, Qian D, Wang B, Yang J, Lu Z. p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. Mol Cell Biol. 2011;31:3906-16 pubmed publisher
    b>ATF5 has been shown to be a critical regulator of cell proliferation and survival; however, the underlying mechanism remains largely unknown...
  36. Sears T, Angelastro J. The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. Oncotarget. 2017;8:84595-84609 pubmed publisher
    Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress...
  37. Gho J, Ip W, Chan K, Law P, Lai P, Wong N. Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest. Cancer Res. 2008;68:6743-51 pubmed publisher
    ..Here, we report on the novel finding of common ATF5 down-regulations in hepatocellular carcinoma (HCC), a highly malignant tumor with a dismal clinical course...
  38. Wang M, Hu M, Li Z, Qian D, Wang B, Liu D. miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma. Biochem Biophys Res Commun. 2017;490:1260-1267 pubmed publisher
    ..Our studies reported that an anti-apoptotic factor, activating transcription factor 5 (ATF5), is highly expressed in malignant glioma specimens and cell lines...
  39. Wei Y, Jiang J, Liu D, Zhou J, Chen X, Zhang S, et al. Cdc34-mediated degradation of ATF5 is blocked by cisplatin. J Biol Chem. 2008;283:18773-81 pubmed publisher
    b>ATF5, a member of activating transcription factor (ATF)/cAMP-response element-binding protein (CREB) family of b-ZIP transcription factors, contributes to neural cell differentiation and is involved in cell apoptosis in response to ..
  40. Zhao Y, Zhang Y, Zhang Y, Qian S, Zhang Z, Li S, et al. p300-dependent acetylation of activating transcription factor 5 enhances C/EBP? transactivation of C/EBP? during 3T3-L1 differentiation. Mol Cell Biol. 2014;34:315-24 pubmed publisher
    ..In this study, we found that activating transcription factor 5 (ATF5) can bind to the promoter of C/EBP? via its direct interaction with C/EBP? (which is mediated via the p300-..
  41. Nakamori D, Akamine H, Takayama K, Sakurai F, Mizuguchi H. Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction. Sci Rep. 2017;7:16675 pubmed publisher
    ..We found that human fibroblasts were efficiently converted into hiHeps by using a combination of ATF5, PROX1, FOXA2, FOXA3, and HNF4A (albumin+/alpha-1 antitrypsin+ cells?=?27%, asialoglycoprotein receptor 1+ cells?=?..
  42. White J, McIllhinney R, Wise A, Ciruela F, Chan W, Emson P, et al. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. Proc Natl Acad Sci U S A. 2000;97:13967-72 pubmed
    ..between the C-terminal tails of GABA(B)-R1 and GABA(B)-R2 with two related transcription factors, CREB2 (ATF4) and ATFx. In primary neuronal cultures as well in recombinant Chinese hamster ovary cells expressing GABA(B) receptors, ..
  43. Wei Y, Jiang J, Sun M, Chen X, Wang H, Gu J. ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells. Biochem Biophys Res Commun. 2006;339:591-6 pubmed
    b>ATF5 transcription factor plays an essential role in hematopoietic and glioma cell survival and neuronal cell differentiation...
  44. Liu X, Liu D, Qian D, Dai J, An Y, Jiang S, et al. Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells. J Biol Chem. 2012;287:19599-609 pubmed publisher
    Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation...
  45. Wu Y, Wu B, Chen R, Zheng Y, Huang Z. High ATF5 expression is a favorable prognostic indicator in patients with hepatocellular carcinoma after hepatectomy. Med Oncol. 2014;31:269 pubmed publisher
    Activating transcription factor 5 (ATF5) is a member of the ATF/CREB family involved in diverse physiological functions, ranging from metabolite homeostasis to cellular differentiations and regulation of the cell cycle...
  46. Nakamori D, Takayama K, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, et al. Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction. Biochem Biophys Res Commun. 2016;469:424-9 pubmed publisher
    ..Because the gene expression levels of the hepatic transcription factors (activating transcription factor 5 (ATF5), CCAAT/enhancer-binding protein alpha (c/EBPα), and prospero homeobox protein 1 (PROX1)) in adult liver were ..
  47. Nukuda A, Endoh H, Yasuda M, Mizutani T, Kawabata K, Haga H. Role of ATF5 in the invasive potential of diverse human cancer cell lines. Biochem Biophys Res Commun. 2016;474:509-514 pubmed publisher
    Activating transcription factor 5 (ATF5) is a member of the ATF/cAMP response element-binding protein family. Our research group recently revealed that ATF5 expression increases the invasiveness of human lung carcinoma cells...
  48. Andreev D, O Connor P, Fahey C, Kenny E, Terenin I, Dmitriev S, et al. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. elife. 2015;4:e03971 pubmed publisher
    ..Phylogenetic analysis suggests that at least two regulatory uORFs (namely, in SLC35A4 and MIEF1) encode functional protein products. ..
  49. Uekusa H, Namimatsu M, Hiwatashi Y, Akimoto T, Nishida T, Takahashi S, et al. Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway. Biochem Biophys Res Commun. 2009;380:673-8 pubmed publisher
    b>ATF5 is a member of the CREB/ATF family of transcription factors...
  50. Pati D, Meistrich M, Plon S. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. Mol Cell Biol. 1999;19:5001-13 pubmed
    ..This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription...
  51. Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio Henriksson A, Suvisaari J, et al. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry. 2009;65:1055-62 pubmed publisher
    ..Our findings with other converging lines of evidence support the underlying importance of DISC1-related molecular pathways in the etiology of schizophrenia and other major mental illnesses. ..
  52. Li G, Li W, Angelastro J, Greene L, Liu D. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Mol Cancer Res. 2009;7:933-43 pubmed publisher
    Recent reports indicate that the activating transcription factor 5 (ATF5) is required for the survival of cancer cells but not for noncancer cells...
  53. Li G, Xu Y, Guan D, Liu Z, Liu D. HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. J Biol Chem. 2011;286:20251-9 pubmed publisher
    Although both the heat shock protein 70 (HSP70) and the activating transcription factor 5 (ATF5) have been shown to promote cell survival of transformed cells but not survival of non-transformed cells, the relationship of the two ..
  54. Wu L, Zhang X, Che Y, Zhang Y, Tang S, Liao Y, et al. A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5. Sci China Life Sci. 2013;56:1124-33 pubmed publisher
    ..by inhibiting transcription of the viral genome by interacting with the cellular transcription factor, ATF5, via its N-terminal domain...
  55. Morris J, Kandpal G, Ma L, Austin C. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet. 2003;12:1591-608 pubmed
    ..alpha-actinin2 and beta4-spectrin; and proteins which transduce signals from membrane receptors, including ATF4 and ATF5. Truncated mutant DISC1 fails to interact with ATF4, ATF5 or NUDEL...
  56. Al Sarraj J, Vinson C, Thiel G. Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. Biol Chem. 2005;386:873-9 pubmed
    ..Here we show that overexpression of the bZIP protein ATF5, a transcriptional activator, stimulates asparagine synthetase promoter/reporter gene transcription via the ..
  57. Rousseau J, Gagné V, Labuda M, Beaubois C, Sinnett D, Laverdiere C, et al. ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. Blood. 2011;118:5883-90 pubmed publisher
    ..Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) and arginosuccinate synthase 1 (ASS1) have been shown to mediate the antileukemic effect of asparaginase and to ..
  58. Zhang Z, Li S, Zhang H, Wu Q, Gong J, Liang T, et al. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway. Mol Cell Biol. 2015;35:778-88 pubmed publisher
    ..NLK interacted with activating transcription factor 5 (ATF5) and inhibited the proteasome-dependent degradation of ATF5 in a kinase-independent manner...
  59. Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li G, et al. ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. Cell. 2015;162:580-92 pubmed publisher
    ..Here, we show that ATF5 forms a characteristic 9-fold symmetrical ring structure in the inner layer of the PCM outfitting the proximal end ..
  60. Pascual M, Gomez Lechon M, Castell J, Jover R. ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses. Drug Metab Dispos. 2008;36:1063-72 pubmed publisher
    ..However, its role in the liver has not yet been investigated. We show herein that ATF5 is a highly abundant liver-enriched transcription factor (LETF) whose expression declines in correlation with the ..
  61. Angelastro J, Canoll P, Kuo J, Weicker M, Costa A, Bruce J, et al. Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5. Oncogene. 2006;25:907-16 pubmed
    ..We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed...
  62. Hua X, Wang J, Qian D, Song J, Chen H, Zhu X, et al. DNA methylation level of promoter region of activating transcription factor 5 in glioma. J Zhejiang Univ Sci B. 2015;16:757-62 pubmed publisher
    ..Previous researches have shown that the expression level of activating transcription factor 5 (ATF5) was frequently increased in glioma and its acetylation level was related to glioma...