ATF3

Summary

Gene Symbol: ATF3
Description: activating transcription factor 3
Alias: cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3
Species: human
Products:     ATF3

Top Publications

  1. Liang G, Wolfgang C, Chen B, Chen T, Hai T. ATF3 gene. Genomic organization, promoter, and regulation. J Biol Chem. 1996;271:1695-701 pubmed
    b>ATF3 gene, which encodes a member of the activating transcription factor/cAMP responsive element binding protein (ATF/CREB) family of transcription factors, is induced by many physiological stresses...
  2. Lu D, Chen J, Hai T. The regulation of ATF3 gene expression by mitogen-activated protein kinases. Biochem J. 2007;401:559-67 pubmed
    b>ATF3 (activating transcription factor 3) gene encodes a member of the ATF/CREB (cAMP-response-element-binding protein) family of transcription factors...
  3. Kiryu Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K, Kiyama H. Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. J Biol Chem. 2008;283:6988-96 pubmed publisher
    ..The injury-inducible transcription factors such as activating transcription factor 3 (ATF3), c-Jun, and STAT3, which were located at the downstream of leukemia inhibitory factor and nerve growth factor ..
  4. Wu X, Nguyen B, Dziunycz P, Chang S, Brooks Y, Lefort K, et al. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature. 2010;465:368-72 pubmed publisher
    ..b>ATF3, a member of the 'enlarged' AP-1 family, is selectively induced by calcineurin/NFAT inhibition, both under ..
  5. Wang A, Arantes S, Conti C, McArthur M, Aldaz C, MacLeod M. Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells. Mol Carcinog. 2007;46:476-87 pubmed
    b>ATF3 is a highly conserved eukaryotic transcription factor that is ubiquitously upregulated transcriptionally during cellular responses to a variety of stresses, in particular DNA damage...
  6. Hackl C, Lang S, Moser C, Mori A, Fichtner Feigl S, Hellerbrand C, et al. Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. BMC Cancer. 2010;10:668 pubmed publisher
    Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response...
  7. Chen H, Lai P, Lan Y, Cheng C, Zhong W, Lin Y, et al. Exosomal ATF3 RNA attenuates pro-inflammatory gene MCP-1 transcription in renal ischemia-reperfusion. J Cell Physiol. 2014;229:1202-11 pubmed publisher
    Transcriptional repressor activating transcription factor 3 (ATF3) is induced by various stress stimuli, including inflammation-induced renal injury...
  8. Yan C, Wang H, Boyd D. ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. J Biol Chem. 2002;277:10804-12 pubmed
    The murine homologue of the ATF3 transcription factor increases tumor metastases but, surprisingly, represses 72-kDa type IV metalloproteinase (MMP-2) expression...
  9. Yin X, DeWille J, Hai T. A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene. 2008;27:2118-27 pubmed
    Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding family of transcription factors. We present evidence that ATF3 has a dichotomous role in cancer development...

More Information

Publications68

  1. Tanaka Y, Nakamura A, Morioka M, Inoue S, Tamamori Adachi M, Yamada K, et al. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PLoS ONE. 2011;6:e26848 pubmed publisher
    ..Activating transcription factor 3 (ATF3) is induced by a variety of stress and inflammatory conditions and is over-expressed in many kinds of cancer cells...
  2. Miyazaki K, Inoue S, Yamada K, Watanabe M, Liu Q, Watanabe T, et al. Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells. Nucleic Acids Res. 2009;37:1438-51 pubmed publisher
    Stress response gene ATF3 plays a pleiotropic role in determining cell fate in response to mitogenic or stress stimuli...
  3. Pan Y, Chen H, Siu F, Kilberg M. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. J Biol Chem. 2003;278:38402-12 pubmed
    ..Overexpression of the full-length ATF3 protein caused a concentration-dependent biphasic response in ASNS promoter-driven transcription...
  4. Nobori K, Ito H, Tamamori Adachi M, Adachi S, Ono Y, Kawauchi J, et al. ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. J Mol Cell Cardiol. 2002;34:1387-97 pubmed
    ..Although the ATF3 homodimer is known to repress transcription of several genes, its precise biological roles are still unclear...
  5. Kang Y, Chen C, Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell. 2003;11:915-26 pubmed
    ..dictated by the specific ability of the TGFbeta mediator, Smad3, to activate expression of stress response factor ATF3 and then recruit this factor to the Id1 promoter...
  6. Huang X, Li X, Guo B. KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. J Biol Chem. 2008;283:29795-801 pubmed publisher
    ..Here we show that KLF6 induces apoptosis in prostate cancer cells by ATF3 (activating transcription factor 3) expression. KLF6 binds directly to and activates the ATF3 promoter...
  7. Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381-9 pubmed
    ..Here, we summarize the current understanding of the roles of CHOP/GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease. ..
  8. Lee S, Kim J, Yamaguchi K, Eling T, Baek S. Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem Biophys Res Commun. 2005;328:63-9 pubmed
    ..In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1...
  9. Janz M, Hummel M, Truss M, Wollert Wulf B, Mathas S, Johrens K, et al. Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells. Blood. 2006;107:2536-9 pubmed
    ..microarray analysis of Hodgkin and non-Hodgkin cell lines and identified activating transcription factor 3 (ATF3), a member of the cyclic AMP response element binding protein (CREB)/ATF family, as a differentially expressed ..
  10. Kashiwakura Y, Ochiai K, Watanabe M, Abarzua F, Sakaguchi M, Takaoka M, et al. Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis. Cancer Res. 2008;68:8333-41 pubmed publisher
    ..Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 (ATF3) and Smad interaction, with their respective binding motifs, was essential for REIC/Dkk-3-mediated suppression of ..
  11. Cheng C, Lin H. Acute kidney injury and the potential for ATF3-regulated epigenetic therapy. Toxicol Mech Methods. 2011;21:362-6 pubmed publisher
    ..stress response program and express many transcriptional regulators, including activating transcription factor 3 (ATF3). ATF3 is a member of the ATF/CREB subfamily of the basic-region leucine zipper (bZIP) family...
  12. Hasin T, Elhanani O, Abassi Z, Hai T, Aronheim A. Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium. Basic Res Cardiol. 2011;106:175-87 pubmed publisher
    ..Angiotensin II is hypothesized to take part in mediating this response. ATF3 is an immediate early gene found at the receiving end of multiple stress and growth stimuli...
  13. Akram A, Han B, Masoom H, Peng C, Lam E, Litvack M, et al. Activating transcription factor 3 confers protection against ventilator-induced lung injury. Am J Respir Crit Care Med. 2010;182:489-500 pubmed publisher
    ..for genes containing putative binding sites for the transcription factor activating transcription factor 3 (ATF3)...
  14. Yin X, Wolford C, Chang Y, McConoughey S, Ramsey S, Aderem A, et al. ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci. 2010;123:3558-65 pubmed publisher
    The activating transcription factor 3 (ATF3) gene is induced by a variety of signals, including many of those encountered by cancer cells...
  15. Jan Y, Tsai H, Yang C, Huang M, Yang Y, Lai T, et al. Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3. Cancer Res. 2012;72:5119-29 pubmed publisher
    ..Mechanistically, the transcription factor ATF3 was identified as a pivotal regulatory target of AK4...
  16. Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991;88:3720-4 pubmed
    ..These findings indicate that the Fos/Jun and ATF/CREB families of transcription factors are not as distinct as was previously thought. We suggest that they can be grouped into a superfamily of transcription factors. ..
  17. Chen B, Liang G, Whelan J, Hai T. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. J Biol Chem. 1994;269:15819-26 pubmed
    b>ATF3 is a member of the mammalian activating transcription factor/cAMP responsive element binding protein (ATF/CREB) family of transcription factors...
  18. Chen B, Wolfgang C, Hai T. Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol. 1996;16:1157-68 pubmed
    We demonstrate that ATF3, a member of the ATF/CREB family of transcription factors, is induced in a variety of stressed tissues: mechanically injured liver, toxin-injured liver, blood-deprived heart, and postseizure brain...
  19. Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, et al. ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. Cancer Res. 2013;73:3625-37 pubmed publisher
    ..the clinical and functional significance of the transcription factor activating transcription factor 3 (ATF3) in bladder cancer metastasis...
  20. Kawauchi J, Zhang C, Nobori K, Hashimoto Y, Adachi M, Noda A, et al. Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. J Biol Chem. 2002;277:39025-34 pubmed
    Activating transcription factor 3 (ATF3) is a transcriptional repressor that is rapidly induced in cells exposed to a wide range of stress stimuli...
  21. Hua B, Tamamori Adachi M, Luo Y, Tamura K, Morioka M, Fukuda M, et al. A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator. J Biol Chem. 2006;281:1620-9 pubmed
    ..counteracts anti-apoptotic activity of NF-kappaB, at least in part, by displacing positive cofactor CBP/p300 and provides insight into the mechanism by which ATF3 regulates cell fate through alternative splicing in stress response.
  22. Wang C, Brennan V, Gutierrez N, Wang X, Wang L, Yang W. SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. J Cell Biochem. 2013;114:589-98 pubmed publisher
    Cyclic AMP-dependent transcription factor-3 (ATF3), a stress sensor, plays an essential role in cells to maintain homeostasis and has diverse functions in cellular survival and death signal pathways...
  23. Lee S, Yamaguchi K, Kim J, Eling T, Safe S, Park Y, et al. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 2006;27:972-81 pubmed
    ..Microarray analysis using t10,c12-CLA-treated HCT-116 cells revealed that activating transcription factor 3 (ATF3) was induced and its expression was confirmed by western analysis...
  24. Rynes J, Donohoe C, Frommolt P, Brodesser S, Jindra M, Uhlirova M. Activating transcription factor 3 regulates immune and metabolic homeostasis. Mol Cell Biol. 2012;32:3949-62 pubmed publisher
    ..Here, we show that the Drosophila melanogaster activating transcription factor 3 (Atf3) safeguards metabolic and immune system homeostasis...
  25. Wang H, Jiang M, Cui H, Chen M, Buttyan R, Hayward S, et al. The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol Cell Biol. 2012;32:3190-202 pubmed publisher
    Activating transcription factor 3 (ATF3) is a common mediator of cellular stress response signaling and is often aberrantly expressed in prostate cancer...
  26. Weigelt K, Carvalho L, Drexhage R, Wijkhuijs A, de Wit H, van Beveren N, et al. TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Brain Behav Immun. 2011;25:1162-9 pubmed publisher
    ..1 are increased in monocytes of patients with severe psychiatric disorders and (2) if PU.1 and the TFs ATF3 and EGR3 (which have been found as prominent increased monocyte genes in previous studies) are involved in the ..
  27. Kim W, Jang M, Kim C, Shin H, Jung M. ATF3 inhibits PDX-1-stimulated transactivation. Biochem Biophys Res Commun. 2011;414:681-7 pubmed publisher
    ..Previously, we showed that ATF3 downregulates PDX-1 gene expression in MIN6N8 pancreatic ?-cells...
  28. Hai T, Liu F, Coukos W, Green M. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 1989;3:2083-90 pubmed
    ..Our results help to explain how a single promoter element, an ATF site, can be present in a wide variety of promoters. ..
  29. Hai T, Wolford C, Chang Y. ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component?. Gene Expr. 2010;15:1-11 pubmed
    Activating transcription factor 3 (ATF3) gene encodes a member of the ATF family of transcription factors and is induced by various stress signals...
  30. Lindå H, Sköld M, Ochsmann T. Activating transcription factor 3, a useful marker for regenerative response after nerve root injury. Front Neurol. 2011;2:30 pubmed publisher
    Activating transcription factor 3 (ATF3) is induced in various tissues in response to stress...
  31. Taketani K, Kawauchi J, Tanaka Okamoto M, Ishizaki H, Tanaka Y, Sakai T, et al. Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. Oncogene. 2012;31:2210-21 pubmed publisher
    Stress response gene ATF3 is one of the p53 target genes and has a tumor suppressor role in cancer. However, the biological role of p53-ATF3 pathway is not well understood...
  32. Mo P, Wang H, Lu H, Boyd D, Yan C. MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010;285:26908-15 pubmed publisher
    Activating transcription factor 3 (ATF3) is a common stress sensor, and its rapid induction by cellular stresses (e.g. DNA damage) is crucial for cells to mount appropriate responses (e.g...
  33. Hashimoto Y, Zhang C, Kawauchi J, Imoto I, Adachi M, Inazawa J, et al. An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res. 2002;30:2398-406 pubmed
    Activating transcription factor 3 (ATF3) is a member of the ATF/CREB family of transcription factors and its expression is increased by various pathophysiological conditions and in several cancer cells...
  34. Zhang C, Gao C, Kawauchi J, Hashimoto Y, Tsuchida N, Kitajima S. Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun. 2002;297:1302-10 pubmed
    Activating transcription factor 3 (ATF3) is an immediate early response gene that is induced in cells exposed to a variety of stress stimuli...
  35. Fan F, Jin S, Amundson S, Tong T, Fan W, Zhao H, et al. ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene. 2002;21:7488-96 pubmed
    ..In this paper, we demonstrate that induction of ATF3 protein, a member of the ATF/CREB family of transcription factors, by ionizing radiation (IR) requires normal ..
  36. Newman J, Keating A. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science. 2003;300:2097-101 pubmed
    ..Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response. ..
  37. Yan C, Lu D, Hai T, Boyd D. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J. 2005;24:2425-35 pubmed
    Activating transcription factor 3 (ATF3) is rapidly induced by diverse environmental insults including genotoxic stress...
  38. Bottone F, Moon Y, Alston Mills B, Eling T. Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. J Pharmacol Exp Ther. 2005;315:668-77 pubmed
    Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide...
  39. Pan Y, Chen H, Thiaville M, Kilberg M. Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem J. 2007;401:299-307 pubmed
    Expression of ATF3 (activating transcription factor 3) is induced by a variety of environmental stress conditions, including nutrient limitation...
  40. Bandyopadhyay S, Wang Y, Zhan R, Pai S, Watabe M, Iiizumi M, et al. The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer. Cancer Res. 2006;66:11983-90 pubmed
    ..We also showed that Drg-1 attenuated the endogenous level of ATF3 mRNA and protein in prostate cancer cells, whereas Drg-1 small interfering RNA up-regulated the ATF3 expression...
  41. Wang Q, Mora Jensen H, Weniger M, Perez Galan P, Wolford C, Hai T, et al. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A. 2009;106:2200-5 pubmed publisher
    ..these agents elicit an integrated stress response program at the ER to activate the CREB/ATF transcription factors ATF3 and ATF4...
  42. Wang H, Mo P, Ren S, Yan C. Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J Biol Chem. 2010;285:13201-10 pubmed publisher
    ..Here we report that activating transcription factor 3 (ATF3), a broad DNA damage sensor whose expression is frequently downregulated in cervical cancer, interacted with E6 and ..
  43. Li H, Cheng C, Liao W, Lin H, Yang R. ATF3-mediated epigenetic regulation protects against acute kidney injury. J Am Soc Nephrol. 2010;21:1003-13 pubmed publisher
    A variety of stress stimuli, including ischemia-reperfusion (I/R) injury, induce the transcriptional repressor ATF3 in the kidney. The functional consequences of this upregulation in ATF3 after renal I/R injury are not well understood...
  44. Lee S, Bahn J, Whitlock N, Baek S. Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. Oncogene. 2010;29:5182-92 pubmed publisher
    ..Activating transcription factor 3 (ATF3) is a member of the ATF/CREB subfamily of the basic region-leucine zipper family and has been known as a tumor ..
  45. Kim J, Lee S, Song E, Park Y, Lim J, Kim D, et al. A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: controlled by ATF3. Cell Signal. 2009;21:1758-67 pubmed publisher
    ..Similarly, STZ-induced ATF3, a stress-inducible gene, was completely abolished in the liver of IFN-gamma(-/-) mice, but not in STAT1(-/-) mice...
  46. Pearson A, Gray C, Pearson J, Greenwood J, During M, Dragunow M. ATF3 enhances c-Jun-mediated neurite sprouting. Brain Res Mol Brain Res. 2003;120:38-45 pubmed
    ..More recently there has been interest in the c-Jun-related bZIP transcription factor, ATF3, and its function in neurons...
  47. Allan A, Albanese C, Pestell R, LaMarre J. Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes. J Biol Chem. 2001;276:27272-80 pubmed
    Activating transcription factor 3 (ATF3) is an early response gene that is induced rapidly during in vivo situations of cellular growth such as liver regeneration...
  48. Sharp J, Brennan A, Polekhina G, Ascher D, Lefevre C, Nicholas K. Dimeric but not monomeric ?-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells. Cell Signal. 2017;33:86-97 pubmed publisher
    ..We also show that 28kDa ?-lactalbumin occurs naturally in the milk of cows, goats and sheep, is low in concentration during mid-lactation, but accumulates during milk stasis, consistent with a role in involution. ..
  49. Rizzo R, Soffritti I, D Accolti M, Bortolotti D, Di Luca D, Caselli E. HHV-6A/6B Infection of NK Cells Modulates the Expression of miRNAs and Transcription Factors Potentially Associated to Impaired NK Activity. Front Microbiol. 2017;8:2143 pubmed publisher
    ..expression of transcription factors was significantly modified by HHV-6A/6B infection, with an early increase of ATF3, JUN and FOXA2 by both species, whereas HHV-6A specifically induced a 15-fold decrease of POU2AF1, and HHV-6B an ..
  50. Chen Y, Yang C, Zhu L, Li J, Guan F, Chen T. Depletion of D3 dopamine receptor affects methamphetamine-induced expression patterns of Pde4b and Atf3. Neurosci Lett. 2018;665:54-60 pubmed publisher
    ..Here, we measured changes in Pde4b and Atf3 in the cAMP signaling pathway of dopaminergic system components, including the nucleus accumbens (NAc), caudate ..
  51. Celik H, Bulut G, Han J, Graham G, Minas T, Conn E, et al. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016;291:13257-70 pubmed publisher
    ..We identified and validated several up-regulated integrated stress response genes including PTGS2, ATF3, DDIT3, DDIT4, TRIB3, and ATF4 as novel ezrin-regulated transcripts...
  52. Lee J, Lee M, Eo H, Park G, Song H, Kim M, et al. The contribution of activating transcription factor 3 to apoptosis of human colorectal cancer cells by protocatechualdehyde, a naturally occurring phenolic compound. Arch Biochem Biophys. 2014;564:203-10 pubmed publisher
    ..However, the underlying mechanisms for the expression of activating transcription factor 3 (ATF3) by PCA has not been studied...
  53. Chen Y, Tsai Y, Lee C, Lee C, Chen C, Liu C, et al. Urotensin II inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating ATF expression and via the ERK and Akt pathway. PLoS ONE. 2014;9:e106812 pubmed publisher
    ..U-II induced Activating transcription factor 3 (ATF3) at both mRNA and protein levels in U-II-treated cells...
  54. Aung H, Altman R, Nyunt T, Kim J, Nuthikattu S, Budamagunta M, et al. Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res. 2016;57:955-68 pubmed publisher
    ..increased mitochondrial superoxide radical generation, upregulation of activating transcription factor 3 (ATF3)-dependent inflammatory pathways, and activation of cellular oxidative stress and apoptotic pathways...
  55. Li X, Cornelis M, Liang L, Song F, De Vivo I, Giovannucci E, et al. A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. Carcinogenesis. 2016;37:1138-1143 pubmed
    ..001) including those mapping to the genes LRRTM4, ATF3 and DCLRE1C in women and POTEA in men...
  56. Zigler M, Villares G, Dobroff A, Wang H, Huang L, Braeuer R, et al. Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res. 2011;71:3494-504 pubmed publisher
    ..To our knowledge, this is the first demonstration that MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis. ..
  57. Yan F, Ying L, Li X, Qiao B, Meng Q, Yu L, et al. Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancer. Oncotarget. 2017;8:47020-47036 pubmed publisher
    ..The expression of the transcription factor ATF3 was elevated in human CRC specimens in a TMA by immunochemistry analysis compared to the adjacent normal tissues...
  58. Zhou J, Wang H, Peng Y, Chen Q, Da J, Wang Z, et al. [Expressions of ATF3 and CTGF and their regulation by estradiol in the prepuce of hypospadias patients]. Zhonghua Nan Ke Xue. 2009;15:1075-80 pubmed
    ..of the cells, and RT-PCR was employed to detect the expressions of the activating transcription factor-3 (ATF3) and connective tissue growth factor (CTGF) in the hypospadiac tissue...
  59. Park H, Kang Y, Kim C, Jung M. ATF3 negatively regulates adiponectin receptor 1 expression. Biochem Biophys Res Commun. 2010;400:72-7 pubmed publisher
    ..Previously, we demonstrated that endoplasmic reticulum (ER) stress or obesity-inducible ATF3 negatively regulates the expression of adiponectin and AdipoR2...