Gene Symbol: ATF2
Description: activating transcription factor 2
Alias: CRE-BP1, CREB-2, CREB2, HB16, TREB7, cyclic AMP-dependent transcription factor ATF-2, activating transcription factor 2 splice variant ATF2-var2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, histone acetyltransferase ATF2
Species: human
Products:     ATF2

Top Publications

  1. Sangerman J, Lee M, Yao X, Oteng E, Hsiao C, Li W, et al. Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2. Blood. 2006;108:3590-9 pubmed
    ..The data presented herein demonstrate that gamma-gene induction by butyrate and trichostatin A involves ATF-2 and CREB1 activation via p38 MAPK signaling. ..
  2. Fuchs S, Ronai Z. Ubiquitination and degradation of ATF2 are dimerization dependent. Mol Cell Biol. 1999;19:3289-98 pubmed
    ..Here we show that activating transcription factor 2 (ATF2) heterodimerization with specific bZIP proteins is an important determinant of the ubiquitination and proteasome-..
  3. Bhoumik A, RONAI Z. ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle. 2008;7:2341-5 pubmed
    The Activating Transcription Factor (ATF2) gene encodes a transcription factor important for normal cellular development and survival...
  4. Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, et al. ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature. 2000;405:195-200 pubmed
    ..ATF-2 may represent a new class of sequence-specific factors, which are able to activate transcription by direct effects on chromatin components. ..
  5. Woo I, Kohno T, Inoue K, Ishii S, Yokota J. Infrequent mutations of the activating transcription factor-2 gene in human lung cancer, neuroblastoma and breast cancer. Int J Oncol. 2002;20:527-31 pubmed
    ..The present result indicates that the ATF-2 gene is not a major tumor suppressor gene on chromosome 2q, however, it is possible that ATF-2 alterations may be involved in the development of a small subset of lung cancers. ..
  6. Morton S, Davis R, Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett. 2004;572:177-83 pubmed
    ..In JNK-deficient cells, p38 MAPK substituted for JNK partially in the phosphorylation of Thr69 and p38 MAPK or ERK1/2 in the phosphorylation of Thr71. JNK was the only MAP kinase that phosphorylated Ser90 under the conditions examined. ..
  7. Duyndam M, van Dam H, Smits P, Verlaan M, van der Eb A, Zantema A. The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A. Oncogene. 1999;18:2311-21 pubmed
    ..Here, we present evidence that p300 can control c-jun transcription by acting as a cofactor for ATF2: (1) Over-expression of p300 was found to stimulate c-jun transcription both in the presence and absence of E1A...
  8. Vlahopoulos S, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V. The role of ATF-2 in oncogenesis. Bioessays. 2008;30:314-27 pubmed publisher
  9. Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991;88:3720-4 pubmed
    ..These findings indicate that the Fos/Jun and ATF/CREB families of transcription factors are not as distinct as was previously thought. We suggest that they can be grouped into a superfamily of transcription factors. ..

More Information

Publications110 found, 100 shown here

  1. Salameh A, Galvagni F, Anselmi F, De Clemente C, Orlandini M, Oliviero S. Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL. J Biol Chem. 2010;285:23096-104 pubmed publisher
    ..cells as well as mouse fibroblasts respond with an increased expression of c-Jun that forms a complex with ATF2. This complex activates the expression of the anti-apoptotic protein Bcl-X(L)...
  2. Lau E, Ronai Z. ATF2 - at the crossroad of nuclear and cytosolic functions. J Cell Sci. 2012;125:2815-24 pubmed publisher
    ..Activating transcription factor 2 (ATF2; also known as cAMP-dependent transcription factor ATF-2) has oncogenic activities in melanoma and tumor suppressor ..
  3. Bailey J, Phillips R, Pollard A, Gilmore K, Robson S, Europe Finner G. Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transacti. J Clin Endocrinol Metab. 2002;87:1717-28 pubmed
    ..Similarly, we have isolated two ATF2 proteins of 60,000 and 28,000 mol wts, which represent full-length ATF2 and a novel small isoform of ATF2 that we ..
  4. Kodeboyina S, Balamurugan P, Liu L, Pace B. cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol Dis. 2010;44:7-15 pubmed publisher
    ..We conclude that these data indicate that cJun activates the Ggamma-globin promoter via the G-CRE in a manner comparable with CREB1 and propose a model for gamma-globin activation based on DNA-protein interactions in the G-CRE. ..
  5. Kim S, Wagner S, Liu F, O Reilly M, Robbins P, Green M. Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2. Nature. 1992;358:331-4 pubmed
    ..First, the ATF promoter element in the TGF-beta 2 gene is a high-affinity ATF-2-binding site. Second, a GAL4-ATF2 fusion protein can support pRb-mediated transcriptional activation of a promoter containing GAL4-binding sites...
  6. van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P, Angel P. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 1995;14:1798-811 pubmed
    ..This allows fine tuned modulation of c-jun expression by a large spectrum of extracellular signals. ..
  7. Walluscheck D, Poehlmann A, Hartig R, Lendeckel U, Schonfeld P, Hotz Wagenblatt A, et al. ATF2 knockdown reinforces oxidative stress-induced apoptosis in TE7 cancer cells. J Cell Mol Med. 2013;17:976-88 pubmed publisher
    ..As the transcription factor ATF2 is implicated in all these processes, we focused on this protein. We investigated checkpoint activation via ATF2...
  8. Maekawa T, Sakura H, Kanei Ishii C, Sudo T, Yoshimura T, Fujisawa J, et al. Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J. 1989;8:2023-8 pubmed
  9. Hong S, Choi H, Park M, Kim Y, Choi Y, Kim H, et al. Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid. J Biol Chem. 2004;279:16996-7003 pubmed
    ..Here we show that the transcription factor ATF2 is associated with the induction of granulocytic differentiation, and the molecular interaction of ATF2 with a ..
  10. Ouwens D, de Ruiter N, van der Zon G, Carter A, Schouten J, van der Burgt C, et al. Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J. 2002;21:3782-93 pubmed
    Transcription factor ATF2 regulates gene expression in response to environmental changes...
  11. Hayakawa J, Mittal S, Wang Y, Korkmaz K, Adamson E, English C, et al. Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell. 2004;16:521-35 pubmed
    ..Jun kinases (JNKs) function in diverse roles through phosphorylation and activation of AP-1 components including ATF2 and c-Jun. However, the genes that mediate these processes are poorly understood...
  12. Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, RONAI Z. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell. 2005;18:577-87 pubmed
    Activating transcription factor 2 (ATF2) is regulated by JNK/p38 in response to stress. Here, we demonstrate that the protein kinase ATM phosphorylates ATF2 on serines 490 and 498 following ionizing radiation (IR)...
  13. Livingstone C, Patel G, Jones N. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 1995;14:1785-97 pubmed
    ..The results show that ATF-2, like other members of the ATF/CREB family of DNA binding proteins is regulated by specific signalling pathways. ..
  14. Berger A, Kluger H, Li N, Kielhorn E, Halaban R, RONAI Z, et al. Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Res. 2003;63:8103-7 pubmed
    The transcription factor activating transcription factor 2 (ATF2) has been shown to be associated with melanocytic oncogenesis and melanoma tumor proliferation in preclinical models. The clinical significance of ATF2 expression is unknown...
  15. Faid I, Al Hussaini H, Kilarkaje N. Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Toxicol Appl Pharmacol. 2015;289:482-94 pubmed publisher
    ..Resveratrol inhibited diabetes-induced increases in AP-1 (activator protein-1) components, c-Jun and ATF2 (activating transcription factor 2), but not their phosphorylated forms, to normal control levels (P<0.05)...
  16. Kang M, Das J, Gurunathan S, Park H, Song H, Park C, et al. The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study. Theranostics. 2017;7:4735-4752 pubmed publisher
    ..levels, induced mitochondrial depolarization/dysfunction, and induced apoptotic cell death via the JNK/ATF2-dependent pathway...
  17. Rodríguez M, Márquez S, Montero O, Alonso S, Frade J, Crespo M, et al. Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. Biochem Pharmacol. 2016;102:78-96 pubmed publisher
    ..Pharmacological modulation of the arachidonic acid cascade and the PAF receptor inhibited the binding of P-71Thr-ATF2 (activating transcription factor 2) to the IL23A promoter, thus mirroring their effects on the expression of IL23A ..
  18. Dozmorov M, Wu W, Chakrabarty K, Booth J, Hurst R, Coggeshall K, et al. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. BMC Infect Dis. 2009;9:152 pubmed publisher
    ..anthracis are still unknown as many of the genes involved are poorly annotated. ..
  19. Pajaud J, Ribault C, Ben Mosbah I, Rauch C, Henderson C, Bellaud P, et al. Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration. Cell Death Dis. 2015;6:e1598 pubmed publisher
    ..Furthermore, while JNK and its downstream targets c-Jun and ATF2 were activated during the early steps of the liver regeneration in wild-type animals, the constitutively active JNK ..
  20. Lee I, Lin C, Yang C, Hsiao L, Wu M, Yang C. Resveratrol Attenuates Staphylococcus Aureus-Induced Monocyte Adhesion through Downregulating PDGFR/AP-1 Activation in Human Lung Epithelial Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..Finally, we found that S. aureus induced c-Src/PDGFR/p38 MAPK and JNK1/2-dependent c-Jun and ATF2 activation and in vivo binding of c-Jun and ATF2 to the VCAM-1 promoter, which were inhibited by resveratrol...
  21. Pereira S, Yu W, Moore J, Mori Y, Tsiani E, Giacca A. Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo. Nutr Diabetes. 2016;6:e210 pubmed publisher
    ..SB239063 also prevented IH-induced phosphorylation of activating transcription factor 2 (ATF2), a marker of p38 MAPK activity, in the liver...
  22. Xiao Y, Lu Y, Wang Y, Yan W, Cai W. Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition. Mucosal Immunol. 2019;: pubmed publisher
    ..The Reg4 was indicated as a novel target of activating transcription factor 2 (ATF2) that enhanced Reg4 expression during the intestinal inflammation...
  23. Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley D, et al. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways. J Immunol. 2017;199:477-488 pubmed publisher
    ..pathways in T cell subsets from PNH, including increased gene expression involved in TNFR, IGF1, NOTCH, AP-1, and ATF2 pathways...
  24. Kim S, Asaka M, Higashida K, Takahashi Y, Holloszy J, Han D. ?-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1? in skeletal muscle. Am J Physiol Endocrinol Metab. 2013;304:E844-52 pubmed publisher
    ..and activates the cAMP response element binding protein (CREB) family member activating transcription factor 2 (ATF2), which binds to a cyclic AMP response element (CRE) in the PGC-1? promoter and mediates the increase in PGC-1? ..
  25. Yang C, Hsieh H, Yu P, Lin C, Liu S. IL-1β Induces MMP-9-Dependent Brain Astrocytic Migration via Transactivation of PDGF Receptor/NADPH Oxidase 2-Derived Reactive Oxygen Species Signals. Mol Neurobiol. 2015;52:303-17 pubmed publisher
    ..e., ATF2), which enhanced MMP-9 promoter activity, and thereby turned on transcription of MMP-9 gene...
  26. Kristiansen M, Hughes R, Patel P, Jacques T, Clark A, Ham J. Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons. J Neurosci. 2010;30:10820-32 pubmed publisher
    ..We also show that c-Jun and ATF2 bind to two conserved ATF binding sites in the mkp1 promoter in vitro and in chromatin...
  27. Zhou Q, Gedrich R, Engel D. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. J Virol. 1995;69:4323-30 pubmed
    ..They further suggest that the ATF/CREB-YY1 complex serves as a target for the adenovirus 243-amino-acid E1A protein. ..
  28. Gupta S, Barrett T, Whitmarsh A, Cavanagh J, Sluss H, Derijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996;15:2760-70 pubmed
    ..The protein kinase activity of these JNK isoforms was measured using the transcription factors ATF2, Elk-1 and members of the Jun family as substrates...
  29. Jensen L, Whitehead A. Pellino2 activates the mitogen activated protein kinase pathway. FEBS Lett. 2003;545:199-202 pubmed
    ..These observations suggest a role for the Pellino proteins in the IL1/Toll signaling cascades as scaffold proteins that may regulate signaling branch-points. ..
  30. Pipaon C, Casado J, Bueren J, Fernandez Luna J. Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts. Blood. 2004;103:128-32 pubmed
    ..Together, our data suggest that activation of JNK and expression of Egr-1 gene in B lymphoblasts mediate a cellular response to genotoxic agents that may be induced by FA proteins. ..
  31. Hsu C, Hu C. Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity. J Biol Chem. 2012;287:8621-32 pubmed publisher
    Activating transcription factor 2 (ATF2) belongs to the basic leucine zipper family of transcription factors. ATF2 regulates target gene expression by binding to the cyclic AMP-response element as a homodimer or a heterodimer with c-Jun...
  32. Zhang X, Zhang Y, Fan C, Wang L, Liu Y, Li A, et al. Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway. Tumour Biol. 2017;39:1010428317705515 pubmed publisher
    ..Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer. ..
  33. Lee S, Bahn J, Whitlock N, Baek S. Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. Oncogene. 2010;29:5182-92 pubmed publisher
    ..Overexpression of ATF2 resulted in significant increase in ATF3 promoter activity, and electrophoretic mobility shift assay identified ..
  34. Endo M, Su L, Nielsen T. Activating transcription factor 2 in mesenchymal tumors. Hum Pathol. 2014;45:276-84 pubmed publisher
    Activating transcription factor 2 (ATF2) is a member of activator protein 1 superfamily, which can heterodimerize with other transcription factors regulating cell differentiation and survival...
  35. Feng Y, Yin Y, Ding J, Yuan H, Yang L, Xu J, et al. Alpha-1-antitrypsin suppresses oxidative stress in preeclampsia by inhibiting the p38MAPK signaling pathway: An in vivo and in vitro study. PLoS ONE. 2017;12:e0173711 pubmed publisher
    ..of p-p38MAPK, AAT, signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2)...
  36. Vázquez Ramírez D, Genzel Y, Jordan I, Sandig V, Reichl U. High-cell-density cultivations to increase MVA virus production. Vaccine. 2018;36:3124-3133 pubmed publisher
    ..8 L bioreactor equipped with an ATF2 system...
  37. Agelopoulos M, Thanos D. Epigenetic determination of a cell-specific gene expression program by ATF-2 and the histone variant macroH2A. EMBO J. 2006;25:4843-53 pubmed
    ..siRNA against ATF-2 or macroH2A rescues IL-8 transcription in B cells. Thus, a transcription factor can work as a transcriptional repressor by orchestrating and maintaining the assembly of specialized local chromatin architectures. ..
  38. Chen S, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, et al. Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. J Cutan Pathol. 2008;35:722-30 pubmed
    ..pathogenesis of many human tumors, but the expression of phosphorylated (p)-activating transcription factor-2 (p-ATF2), phosphorylated (p)-signal transducer and activator of transcription-3 (p-STAT3) and p53 family (p63 and p73) has ..
  39. Lee H, Sheu S, Yen H, Lai W, Chang J. JNK/ATF2 pathway is involved in iodinated contrast media-induced apoptosis. Am J Nephrol. 2010;31:125-33 pubmed publisher
    Notably, activating transcriptional factor 2 (ATF2), a histone-modification gene, is involved in oxidative stress-induced apoptosis. The aim of this study was to clarify the role of ATF2 in contrast media-induced nephropathy...
  40. Korneev S, Vavoulis D, Naskar S, Dyakonova V, Kemenes I, Kemenes G. A CREB2-targeting microRNA is required for long-term memory after single-trial learning. Sci Rep. 2018;8:3950 pubmed publisher
    ..on Lym-miR-137 whose seed region shows perfect complementarity to a target sequence in the 3' UTR of the mRNA for CREB2, a well-known memory repressor...
  41. Srivastava M, Baig M. NOS1 mediates AP1 nuclear translocation and inflammatory response. Biomed Pharmacother. 2018;102:839-847 pubmed publisher
    ..After endotoxin shock AP1 transcription factor, which comprises Jun, ATF2, and Fos family of proteins, translocates into the nucleus and induces proinflammatory cytokine expression...
  42. Chen G, Hitomi M, Han J, Stacey D. The p38 pathway provides negative feedback for Ras proliferative signaling. J Biol Chem. 2000;275:38973-80 pubmed
    ..These studies thus establish a negative feedback mechanism by which Ras proliferative activity is regulated via signaling integrations of MAPK pathways. ..
  43. Fledderus J, van Thienen J, Boon R, Dekker R, Rohlena J, Volger O, et al. Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2. Blood. 2007;109:4249-57 pubmed
    ..human endothelial cells overlying atherosclerotic plaques had increased amounts of phosphorylated nuclear ATF2 compared with endothelium at unaffected sites...
  44. Chaveroux C, Jousse C, Cherasse Y, Maurin A, Parry L, Carraro V, et al. Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals. Mol Cell Biol. 2009;29:6515-26 pubmed publisher
    ..This event requires phosphorylation of activating transcription factor 2 (ATF2), a constitutive AARE-bound factor...
  45. Desai S, Kumar A, Laskar S, Pandey B. Differential roles of ATF-2 in survival and DNA repair contributing to radioresistance induced by autocrine soluble factors in A549 lung cancer cells. Cell Signal. 2014;26:2424-35 pubmed publisher
    ..Our study revealed that, autocrine soluble factors regulate dual but differential role of ATF-2 as a transcription factor or DNA repair protein, which collectively culminate in radioresistance of A549 cells. ..
  46. Schulz S, Immel U, Just L, Schaller H, Gläser C, Reichert S. Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis. Hum Immunol. 2016;77:71-75 pubmed publisher
    ..We assessed CpG methylation in 22 inflammatory candidate genes (ATF2, CCL25, CXCL14, CXCL3, CXCL5, CXCL6, FADD, GATA3, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL15, IL17C, IL17RA, IL4R, ..
  47. Srivastava M, Saqib U, Naim A, Roy A, Liu D, Bhatnagar D, et al. The TLR4-NOS1-AP1 signaling axis regulates macrophage polarization. Inflamm Res. 2017;66:323-334 pubmed publisher
    ..Pharmacological inhibition of NOS1 inhibits ATF2 and Jun dimer...
  48. New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood L, et al. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 1998;17:3372-84 pubmed
    ..An in-gel kinase assay demonstrated that PRAK is a major stress-activated kinase that can phosphorylate small heat shock protein, suggesting a potential role for PRAK in mediating stress-induced HSP27 phosphorylation in vivo. ..
  49. Westermarck J, Li S, Kallunki T, Han J, Kahari V. p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression. Mol Cell Biol. 2001;21:2373-83 pubmed
    ..These results provide evidence that activation of signaling cascade MKK3-MKK3b-->p38alpha blocks the ERK1,2 pathway at the level of MEK1,2 via PP1-PP2A and inhibits the activation of MMP-1 gene expression. ..
  50. Jonsson E, Damberg M, Forslund K, Mattila Evenden M, Rylander G, Asberg M, et al. No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia. Neurosci Lett. 2002;330:290-2 pubmed
    ..We conclude that the investigated AP-2beta variant is not of major importance to schizophrenia in the investigated Swedish population. ..
  51. Wen Sheng W. ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. Oncogene. 2003;22:955-63 pubmed
    ..During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2...
  52. Le N, van der Wal A, van der Bent P, Lantinga van Leeuwen I, Breuning M, van Dam H, et al. Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2005;16:2724-31 pubmed
    ..Here, it is reported that activity of the AP-1 components c-Jun, ATF2, and c-Fos is altered in renal cystic tissue of patients with autosomal dominant polycystic kidney disease and of ..
  53. Xu Y, Zhao C, Sun X, Liu Z, Zhang J. MicroRNA-761 regulates mitochondrial biogenesis in mouse skeletal muscle in response to exercise. Biochem Biophys Res Commun. 2015;467:103-8 pubmed publisher
    ..The phosphorylation of activating transcription factors 2 (ATF2) that plays a functional role in linking the activation of the p38 MAPK pathway to enhanced transcription of the ..
  54. Zhang S, Gao L, Thakur A, Shi P, Liu F, Feng J, et al. miRNA-204 suppresses human non-small cell lung cancer by targeting ATF2. Tumour Biol. 2016;37:11177-86 pubmed publisher
    ..Additionally, activating transcription factor 2 (ATF2), an important transcription factor, was demonstrated as a potential target gene of miR-204...
  55. Ho D, Bardwell A, Abdollahi M, Bardwell L. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003;278:32662-72 pubmed
    ..These same peptides also inhibited JNK2-mediated phosphorylation of c-Jun and ATF2, suggesting that transcription factors, MKK4, and the JIP scaffold compete for docking to JNK...
  56. Colmone A, Li S, Wang C. Activating transcription factor/cAMP response element binding protein family member regulated transcription of CD1A. J Immunol. 2006;177:7024-32 pubmed
    ..The fact that these factors also bind the CD1A promoter in human monocytes strongly suggests a role for ATF/CREB family members in regulation of CD1A expression. ..
  57. Hay C, Ferguson L, Docherty K. ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence. Biochim Biophys Acta. 2007;1769:79-91 pubmed
    ..These results suggest that ATF-2 may be a key regulator of the human insulin promoter possibly stimulating activity in response to extracellular signals. ..
  58. Liu S, Wang F, Yan L, Zhang L, Song Y, Xi S, et al. Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic. Arch Toxicol. 2013;87:981-9 pubmed publisher
    b>ATF2 is a subfamily member of AP-1 and has an important role in cellular stress responses. ATF2 has been implicated in a transcriptional response leading to cell migration and malignant tumor progression...
  59. Gozdecka M, Lyons S, Kondo S, Taylor J, Li Y, Walczynski J, et al. JNK suppresses tumor formation via a gene-expression program mediated by ATF2. Cell Rep. 2014;9:1361-74 pubmed publisher
    ..b>ATF2 is a phosphorylation-dependent transcription factor and substrate of both JNK and p38...
  60. DeLigio J, Lin G, Chalfant C, Park M. Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis. J Biol Chem. 2017;292:17909-17918 pubmed publisher
    ..Overall, this study demonstrates that CPEB2 alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis. ..
  61. Tournier C, Whitmarsh A, Cavanagh J, Barrett T, Davis R. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997;94:7337-42 pubmed
    ..Expression of MKK7 in cultured cells causes activation of the JNK signal transduction pathway. MKK7 is therefore established to be a novel component of the JNK signal transduction pathway. ..
  62. Kumawat K, Pathak S, Spetz A, Kundu M, Basu J. Exogenous Nef is an inhibitor of Mycobacterium tuberculosis-induced tumor necrosis factor-alpha production and macrophage apoptosis. J Biol Chem. 2010;285:12629-37 pubmed publisher
    ..Nef inhibits ASK1/p38 MAPK-dependent Mtb-induced TNF-alpha production probably by inhibiting binding of ATF2 to the TNF-alpha promoter. It also inhibits MEK/ERK-dependent Mtb-induced binding of FosB to the promoter...
  63. Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, et al. A Conserved Role of the Unconventional Myosin 1d in Laterality Determination. Curr Biol. 2018;28:810-816.e3 pubmed publisher
    ..Indeed, convergent extension of gastrula explant cultures was inhibited in myo1d morphants, and the ATF2 reporter gene for non-canonical Wnt signaling was downregulated...
  64. Ainbinder E, Bergelson S, Pinkus R, Daniel V. Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents. Eur J Biochem. 1997;243:49-57 pubmed
    ..Furthermore, we find that activation by phorbol 12-myristate 13-acetate, which uses both protein kinase C and protein-tyrosine kinase activities, may share a common pathway with these chemicals downstream of Ras. ..
  65. Nilsson K, Sjoberg R, Leppert J, Oreland L, Damberg M. Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology. J Neural Transm (Vienna). 2009;116:363-70 pubmed publisher
    ..Amongst carriers of one or two copies of the long allele, there was no difference in depressive symptoms despite differences in psychosocial environments. ..
  66. Diring J, Camuzeaux B, Donzeau M, Vigneron M, Rosa Calatrava M, Kedinger C, et al. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity. PLoS ONE. 2011;6:e23351 pubmed publisher
    ..The nuclear ATF7 and ATF2 (activating transcription factor) are structurally homologous leucine zipper transcription factors encoded by ..
  67. Zeke A, Misheva M, Remenyi A, Bogoyevitch M. JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev. 2016;80:793-835 pubmed publisher
    ..Examples of these JNK substrates include a diverse assortment of nuclear transcription factors (Jun, ATF2, Myc, Elk1), cytoplasmic proteins involved in cytoskeleton regulation (DCX, Tau, WDR62) or vesicular transport (..
  68. Chen Z, Cobb M. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem. 2001;276:16070-5 pubmed
    ..Activation of endogenous TAO2 during differentiation of C2C12 myoblasts paralleled activation of p38 but not JNK/SAPK, consistent with the idea that TAO2 is a physiological regulator of p38 under certain circumstances. ..
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    ..The proximity of these potential phosphorylation sites to one another indicates that they may interact either positively or negatively to regulate CREB bioactivity. ..
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    ..It is known that UV-induced RhoB expression results from the binding of activating transcription factor 2 (ATF2) via NF-Y to the inverted CCAAT box (-23) of the RhoB promoter...
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    ..a core SS18-SSX complex and discovered that SS18-SSX serves as a bridge between activating transcription factor 2 (ATF2) and transducin-like enhancer of split 1 (TLE1), resulting in repression of ATF2 target genes...
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    ..This TNF-responsive element contains potential binding sites for ETS1 and ATF2 transcription factors related to TNF signaling...
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    ..Also, different fractions obtained from the AtD were evaluated (AtF1, AtF2 and AtF3, 15mg/kg), and showed that fraction AtF1 possessed the anxiolytic activity, in the same model...
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    ..and RNA interference we showed that these effects of high salt on IFNβ signaling were mediated by the p38 MAPK/ATF2/AP1 signaling pathway...
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    ..The identification and characterization of the components of eukaryotic transcription complexes will allow studies that address the molecular mechanisms of normal and abnormal control of cellular gene expression. ..
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    ..Our findings suggest that resistin-mediated inhibition of insulin signaling and eNOS activation may contribute to cardiovascular diseases. ..
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    Activating transcription factor 2 (ATF2) and signal transducer and activator of transcription 3 (STAT3) play important roles in the pathogenesis of various tumors, but ATF2 expression/activation and the relationship with STAT3 activation ..
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