ATF1

Summary

Gene Symbol: ATF1
Description: activating transcription factor 1
Alias: EWS-ATF1, FUS/ATF-1, TREB36, cyclic AMP-dependent transcription factor ATF-1, cAMP-dependent transcription factor ATF-1
Species: human
Products:     ATF1

Top Publications

  1. Zheng D, Cho Y, Lau A, Zhang J, Ma W, Bode A, et al. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res. 2008;68:7650-60 pubmed publisher
    ..Furthermore, we found that cdk3 phosphorylates activating transcription factor 1 (ATF1) at serine 63 and enhances the transactivation and transcriptional activities of ATF1...
  2. Huang G, Guo H, Yang F, Liu O, Li B, Liu X, et al. Activating transcription factor 1 is a prognostic marker of colorectal cancer. Asian Pac J Cancer Prev. 2012;13:1053-7 pubmed
    ..This study was to investigate the clinicopathological and prognostic value of activating transcription factor 1 (ATF1) in CRC. Protein expression of ATF1 was detected using immunohistochemistry in 66 CRC tissues...
  3. Papp G, Máté G, Mike N, Gazdag Z, Pesti M. Regulation of the antioxidant system in cells of the fission yeast Schizosaccharomyces pombe after combined treatment with patulin and citrinin. Toxicon. 2016;111:100-7 pubmed publisher
    ..or CTN treatment, suggesting toxin-specific regulation of glutathione and the enzymes of the antioxidant system and the possibility that the transcription factor (pap1 and atf1) -regulated processes might be influenced directly by ROS.
  4. Zhang L, Jia Z, Mao F, Shi Y, Bu R, Zhang B. Whole-exome sequencing identifies a somatic missense mutation of NBN in clear cell sarcoma of the salivary gland. Oncol Rep. 2016;35:3349-56 pubmed publisher
    ..1061C>T (p.P354L) in the NBN gene in a patient with CCS lacking an EWSR1-ATF1 fusion...
  5. Hwang J, Chou C, Medvar B, Knepper M, Jung H. Identification of ?-catenin-interacting proteins in nuclear fractions of native rat collecting duct cells. Am J Physiol Renal Physiol. 2017;313:F30-F46 pubmed publisher
    ..could interact with ?-catenin in the regulation of Aqp2 gene transcription, specifically Jun, Junb, Jund, Atf1, Atf2, Mef2d, Usf1, Max, Pou2f1, and Rxra...
  6. Golubkov V, Strongin A. Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells. Cell Commun Signal. 2014;12:15 pubmed publisher
    ..In turn, the C-terminal fragments of PTK7 act predominantly via the RAS-ERK and CREB/ATF1 pathway and through the up-regulation of cadherin-11...
  7. Seguinot P, Rollero S, Sanchez I, Sablayrolles J, Ortiz Julien A, Camarasa C, et al. Impact of the timing and the nature of nitrogen additions on the production kinetics of fermentative aromas by Saccharomyces cerevisiae during winemaking fermentation in synthetic media. Food Microbiol. 2018;76:29-39 pubmed publisher
    ..other than propanol was unchanged, and acetate esters were overproduced due to the overexpression of the genes ATF1 and ATF2...
  8. Goh G, Teh M, Vanecek T, Moran C, Petersson F. Primary pulmonary clear cell sarcoma-the first two reported cases. Virchows Arch. 2016;469:111-7 pubmed publisher
    ..Fluorescence in situ hybridization showed positive EWSR1 gene rearrangement, and a presence of EWS-ATF1 fusion transcript was confirmed by RT-PCR and sequencing in one case.
  9. Breton S, Dubois M, Geay J, Gillebert Q, Tordjman M, Guinebretiere J, et al. [Clear cell sarcoma or gastrointestinal neuroectodermal tumor (GNET) of the tongue? Case report and review of the literature of an extremely rare tumor localization]. Ann Pathol. 2019;39:167-171 pubmed publisher
    ..SCC and SCCLGI/GNET characteristic molecular profil involves EWSR1-ATF1 [t(12; 22) (q13; q12)] and EWSR1-CREB1 [t(2; 22) (q34; q12)] fusion genes, but it is not specific of these tumours.

More Information

Publications165 found, 100 shown here

  1. Agaimy A. Paraneoplastic disorders associated with miscellaneous neoplasms with focus on selected soft tissue and Undifferentiated/ rhabdoid malignancies. Semin Diagn Pathol. 2019;: pubmed publisher
    ..gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
  2. Su Y, Chen C, Huang L, Yan J, Huang Y. Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase-Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance. PLoS ONE. 2015;10:e0143888 pubmed publisher
    ..The induction of hsp3101, hsp3102, hsp3105 and sdj1 involves the Sty1-regulated transcription factor Atf1 but not the transcription factor Pap1. Our results firmly establish that S...
  3. Bigagli E, Luceri C, Bernardini S, Dei A, Filippini A, Dolara P. Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles. Homeopathy. 2014;103:127-32 pubmed publisher
    ..We confirmed these data by RT-PCR analyses on 5 selected candidate genes (IL1β, CD46, ATF1, UBE2Q2 and MT1X)...
  4. Huang X, Yu P, Liu M, Deng Y, Dong Y, Liu Q, et al. ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway. Int Immunopharmacol. 2019;66:236-241 pubmed publisher
    ..decreased release of inflammatory cytokines of IL-6, IL-12 and IL-17A, and further regulated the mRNA expression of ATF1 and protein expression of ERK1/2 in IMQ-induced skin lesions...
  5. Su Y, Di C, Bien S, Huang L, Dong X, Abecasis G, et al. A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics. Am J Hum Genet. 2018;102:904-919 pubmed publisher
    ..We apply our approach to a large-scale GWAS of colorectal cancer and identify two genes, POU5F1B and ATF1, which would have otherwise been missed by PrediXcan, after adjusting for all known loci.
  6. Xiong X, Wang X, Chen S. Engineering of an L-arabinose metabolic pathway in Rhodococcus jostii RHA1 for biofuel production. J Ind Microbiol Biotechnol. 2016;43:1017-25 pubmed publisher
    ..9 to 56.8 % of the cell dry weight (CDW) by overexpression of a gene, atf1 encoding a diglyceride acyltransferase from R. opacus PD630...
  7. Li Y, Lan X, Wu L, DU X, Ezra K, Li D, et al. [Bidirectional regulation of Pam3CSK4?induced inflammatory response by ATP?binding cassette transporter A1 knockdown in mouse mononuclear macrophages in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1563-1569 pubmed
    ..transcription factor 3 (ATF3) without obviously affecting the expressions of the transcription factors ATF1, ATF2, ATF4 or ATF5. ABCA1 knockdown in macrophages may have both proinflammatory and anti?inflammatory effects...
  8. Ding J, Kong W, Mou X, Wang S. Construction of Transcriptional Regulatory Network of Alzheimer's Disease Based on PANDA Algorithm. Interdiscip Sci. 2018;: pubmed publisher
    ..Eventually, not only a number of genes such as E2F4 and ATF1 related to the pathogenesis of AD have been identified, but also several significant biological processes, such as ..
  9. Kervarrec T, Lecointre C, Kerdraon R, Bens G, Piquard A, Michenet P. [Gastro-intestinal neuroectodermal tumor (GNET): A case report of a small intestine tumor with hepatic metastases]. Ann Pathol. 2015;35:506-10 pubmed publisher
    ..The histological examination showed a diffuse proliferation of epithelioid cells, which only express PS100. The presence EWSR1-ATF1 gene fusions with any melanocytic differentiation leads to the diagnosis of GNET.
  10. Allanson B, Weber M, Jackett L, Chan C, Lau L, Ziegler D, et al. Oral malignant gastrointestinal neuroectodermal tumour with junctional component mimicking mucosal melanoma. Pathology. 2018;50:648-653 pubmed publisher
    ..Whole genome and RNA sequencing was performed that demonstrated the EWSR1-ATF1 translocation characteristic of GNET...
  11. Liu P, Duan C, Yan G. Comparing the Effects of Different Unsaturated Fatty Acids on Fermentation Performance of Saccharomyces cerevisiae and Aroma Compounds during Red Wine Fermentation. Molecules. 2019;24: pubmed publisher
    ..genes, such as BAT1, BAT2, PDC1, PDC5, PDC6, ACC1, FAS1, ATF1, EEB1, and EHT1 were correlated with aroma compounds productions in different treatments...
  12. Cheng L, Pandya P, Liu E, Chandra P, Wang L, Murray M, et al. Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma. BMC Med Genomics. 2019;12:23 pubmed publisher
    ..sensitivity or resistance to 17 chemotherapies from which actionable CNV signatures such as IGF1R, MYC, MAPK1, ATF1, and MDM2 were identified...
  13. Zhu J, Lin J, Palomec L, Wheeldon I. Microbial host selection affects intracellular localization and activity of alcohol-O-acetyltransferase. Microb Cell Fact. 2015;14:35 pubmed publisher
    ..The series of AATases includes Atf1 and Atf2 from S. cerevisiae, as well as AATases from S...
  14. Liu P, Yu K, Li Y, Duan C, Yan G. The content of linoleic acid in grape must influences the aromatic effect of branched-chain amino acids addition on red wine. Food Res Int. 2018;114:214-222 pubmed publisher
    ..The transcriptional data revealed that several major genes including GAP1, ADH1, ATF1, ACC1, FAS1 and OLE1 were marked repressed by high LA content...
  15. Dorsey M, Tae H, Sollenberger K, Mascarenhas N, Johansen L, Taparowsky E. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene. 1995;11:2255-65 pubmed
  16. Segawa K, Sugita S, Aoyama T, Kubo T, Asanuma H, Sugawara T, et al. Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor. Diagn Pathol. 2018;13:73 pubmed publisher
    ..and cAMP response element-binding protein (CREB) family members; namely, EWSR1-activating transcription factor 1 (ATF1) and EWSR1-CREB1. In addition, recent studies have suggested the presence of other fusions...
  17. Jelti L, Alorini M, Boivin C, Courville P, Balguerie X, Bonmarchand A, et al. [Angiomatoid fibrous histiocytoma of the radial pulse groove]. Ann Dermatol Venereol. 2018;: pubmed publisher
    ..Fusion transcript EWSR1-ATF1 was found...
  18. Insabato L, Guadagno E, Natella V, Somma A, Bihl M, Pizzolorusso A, et al. An unusual association of malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like) and Ewing sarcoma. Pathol Res Pract. 2015;211:688-92 pubmed publisher
    ..EWSR1 gene rearrangements including EWSR1-ATF1 or EWSR1-CREB1 GENE fusions are typically assessed in these tumors...
  19. Rollero S, Mouret J, Sanchez I, Camarasa C, Ortiz Julien A, Sablayrolles J, et al. Key role of lipid management in nitrogen and aroma metabolism in an evolved wine yeast strain. Microb Cell Fact. 2016;15:32 pubmed publisher
    ..was associated with the repression of genes involved in sterol biosynthesis rather than an enhanced expression of ATF1 and ATF2 (genes coding for the enzymes responsible for the synthesis of acetate esters from higher alcohols)...
  20. Sakumoto M, Oyama R, Takahashi M, Takai Y, Kito F, Shiozawa K, et al. Establishment and proteomic characterization of patient-derived clear cell sarcoma xenografts and cell lines. In Vitro Cell Dev Biol Anim. 2018;54:163-176 pubmed publisher
    Clear cell sarcoma (CCS) is an aggressive mesenchymal malignancy characterized by the unique chimeric EWS-ATF1 fusion gene...
  21. Takada H, Nishida A, Domae M, Kita A, Yamano Y, Uchida A, et al. The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast. Mol Biol Cell. 2010;21:674-85 pubmed publisher
    The highly conserved fission yeast Pmk1 MAPK pathway plays a key role in cell integrity by regulating Atf1, which belongs to the ATF/cAMP-responsive element-binding (CREB) protein family...
  22. Campos García J, Vargas A, Farías Rosales L, Miranda A, Meza Carmen V, Díaz Pérez A. Improving the Organoleptic Properties of a Craft Mezcal Beverage by Increasing Fatty Acid Ethyl Ester Contents through ATF1 Expression in an Engineered Kluyveromyces marxianus UMPe-1 Yeast. J Agric Food Chem. 2018;66:4469-4480 pubmed publisher
    ..the ester contents in a mezcal beverage by using the yeast Kluyveromyces marxianus, which was engineered with the ATF1 gene...
  23. Tai Y, Xiong M, Zhang K. Engineered biosynthesis of medium-chain esters in Escherichia coli. Metab Eng. 2015;27:20-8 pubmed publisher
    ..It was discovered that ATF1 from Saccharomyces cerevisiae was the best enzyme for the formation of both IBAc and IAAc in E. coli...
  24. Steiner W, Recor C, Zakrzewski B. Unique properties of multiple tandem copies of the M26 recombination hotspot in mitosis and meiosis in Schizosaccharomyces pombe. Gene. 2016;593:185-192 pubmed publisher
    ..The hotspot requires a seven bp sequence, ATGACGT, that serves as a binding site for the Atf1-Pcr1 transcription factor, which is also required for activity...
  25. Huang G, Liao D, Chen H, Lu Y, Chen L, Li H, et al. The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression. Cell Death Dis. 2016;7:e2571 pubmed publisher
    The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered...
  26. Núñez A, Franco A, Madrid M, Soto T, Vicente J, Gacto M, et al. Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast. Mol Biol Cell. 2009;20:3996-4009 pubmed publisher
    ..In addition, Cpc2 positively regulates the synthesis of the stress-responsive transcription factor Atf1 and the cytoplasmic catalase, a detoxificant enzyme induced by treatment with hydrogen peroxide...
  27. Hakozaki M, Tamura H, Dobashi Y, Yoshida A, Kato K, Tajino T, et al. Establishment and Characterization of a Novel Human Clear-cell Sarcoma of Soft-tissue Cell Line, RSAR001, Derived from Pleural Effusion of a Patient with Pleural Dissemination. Anticancer Res. 2018;38:5035-5042 pubmed publisher
    ..analysis detected transcripts of the Ewing sarcoma breakpoint region 1-activating transcription factor 1 (EWSR1-ATF1) type 1 fusion gene...
  28. Christiaens J, Franco L, Cools T, De Meester L, Michiels J, Wenseleers T, et al. The fungal aroma gene ATF1 promotes dispersal of yeast cells through insect vectors. Cell Rep. 2014;9:425-32 pubmed publisher
    ..including isoamyl acetate and ethyl acetate, are produced by a dedicated enzyme, the alcohol acetyl transferase Atf1. However, despite much research, the physiological role of acetate ester formation in yeast remains unknown...
  29. Vogels R, Baumhoer D, van Gorp J, Eijkelenboom A, Verdijk M, van Cleef P, et al. Clear Cell Odontogenic Carcinoma: Occurrence of EWSR1-CREB1 as Alternative Fusion Gene to EWSR1-ATF1. Head Neck Pathol. 2018;: pubmed publisher
    ..clear cell carcinoma of the salivary gland, it is one of the epithelial neoplasms known to harbor an EWSR1-ATF1 fusion. Therefore, a link between these tumors seems plausible...
  30. Orozco Lucero E, Dufort I, Sirard M. Regulation of ATF1 and ATF2 transcripts by sequences in their 3' untranslated region in cleavage-stage cattle embryos. Mol Reprod Dev. 2017;84:296-309 pubmed publisher
    ..objective of this study was to assess the influence of cis-elements in the 3'UTR of the developmentally important ATF1 and ATF2 transcripts on their timely translation during first cleavages in bovine embryos...
  31. Tazzari M, Palassini E, Vergani B, Villa A, Rini F, Negri T, et al. Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report. BMC Cancer. 2015;15:58 pubmed publisher
    ..Thus, manipulation of the immune response may have therapeutic potential for this STS subtype and immunotherapy approaches, can be promising therapeutic options for these patients. ..
  32. Hokari R, Lee H, Crawley S, Yang S, Gum J, Miura S, et al. Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1. Am J Physiol Gastrointest Liver Physiol. 2005;289:G949-59 pubmed
    ..VIP induced cAMP response element-binding protein (CREB)/ATF1 phosphorylation, and this was prevented by treatment with inhibitors of either MEK or p38 and by PKA and MSK1 ..
  33. Lorenz D, Meyer L, Grady P, Meyer M, Cam H. Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase. elife. 2014;3:e04506 pubmed publisher
    ..We show that Set1 is recruited by the ATF/CREB homolog Atf1 to heterochromatic loci and promoters of stress-response genes...
  34. Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, et al. Local potentiation of stress-responsive genes by upstream noncoding transcription. Nucleic Acids Res. 2016;44:5174-89 pubmed publisher
    ..noncoding transcription facilitates promoter association of the stress-responsive transcriptional activator Atf1 at the sites of transcription, leading to activation of the downstream stress genes...
  35. Krogerus K, Arvas M, De Chiara M, Magalhães F, Mattinen L, Oja M, et al. Ploidy influences the functional attributes of de novo lager yeast hybrids. Appl Microbiol Biotechnol. 2016;100:7203-22 pubmed publisher
    ..Genome sequencing revealed that several genes related to the formation of flavor-active esters (ATF1, ATF2¸ EHT1, EEB1, and BAT1) were present in higher copy numbers in the higher ploidy hybrid strains...
  36. Daniele L, Nikolarakos D, Keenan J, Schaefer N, Lam A. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management. Crit Rev Oncol Hematol. 2016;102:55-64 pubmed publisher
    ..EWSR1-ATF1 fusion is specific for the carcinoma...
  37. Thway K, Gonzalez D, Wren D, Dainton M, Swansbury J, Fisher C. Angiomatoid fibrous histiocytoma: comparison of fluorescence in situ hybridization and reverse transcription polymerase chain reaction as adjunct diagnostic modalities. Ann Diagn Pathol. 2015;19:137-42 pubmed publisher
    ..histiocytoma is associated with recurrent chromosomal translocations, leading to characteristic EWSR1-CREB1, EWSR1-ATF1, and, rarely, FUS-ATF1 gene fusions; fluorescence in situ hybridization (FISH), detecting EWSR1 or FUS ..
  38. Williams M, Biguetti C, Romero Bustillos M, Maheshwari K, Dinçkan N, Cavalla F, et al. Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development. Sci Rep. 2018;8:2979 pubmed publisher
    ..Genome-wide significant associations were found between TA and ATF1 rs11169552 (P = 4.36 × 10-10) and DUSP10 rs6687758 (P = 1...
  39. Yuan J, Mishra P, Ching C. Metabolically engineered Saccharomyces cerevisiae for branched-chain ester productions. J Biotechnol. 2016;239:90-97 pubmed publisher
    ..Mitochondrion-based expression of ATF1 gene in a base strain with an overexpressed valine biosynthetic pathway together with expression of mitochondrion-..
  40. Bulldan A, Shihan M, Goericke Pesch S, Scheiner Bobis G. Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines. Mol Reprod Dev. 2016;83:1092-1101 pubmed publisher
    ..also suppressed the anti-apoptotic protein Bcl-xL; reduced phosphorylation of the transcription factors CREB and ATF1; and down-regulated expression of StAR and P450scc, proteins involved in steroidogenesis...
  41. Bandyopadhyay S, Ghosh P, Basu S, Paul M, Alam S, Das E, et al. Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition. FEMS Microbiol Lett. 2017;364: pubmed publisher
    The transcription factor Atf1 is known to promote cell survival during various stress conditions in Schizosaccharomyces pombe by activating the expression of appropriate genes...
  42. Takahashi T, Ohara Y, Sawatari M, Sueno K. Isolation and characterization of sake yeast mutants with enhanced isoamyl acetate productivity. J Biosci Bioeng. 2017;123:71-77 pubmed publisher
    ..polishing ratio, because unsaturated fatty acids derived from the outer layer of rice repress the expression of ATF1, which encodes an alcohol acetyl transferase...
  43. Soubt M, Marksitzer R, Menoud P, Nagamine Y. Role of tissue-specific transcription factor LFB3 in a cyclic AMP-responsive enhancer of the urokinase-type plasminogen activator gene in LLC-PK1 cells. Mol Cell Biol. 1998;18:4698-706 pubmed
    ..CREB and ATF1 bind to domains A and B, and this binding is enhanced upon phosphorylation by cAMP-dependent protein kinase (..
  44. Kobayashi M, Shimomura A, Hagiwara M, Kawakami K. Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter. Nucleic Acids Res. 1997;25:877-82 pubmed
    ..Transcription of the Na,K-ATPase alpha 1 subunit gene promoter was also stimulated by phosphorylated ATF-1 in vitro. ..
  45. Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Ishikawa A, Tohyama R, et al. Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene. Oral Oncol. 2017;69:46-55 pubmed publisher
    ..To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and characterized this cell line...
  46. Timofeeva M, Kinnersley B, Farrington S, Whiffin N, Palles C, Svinti V, et al. Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. Sci Rep. 2015;5:16286 pubmed publisher
    ..09, p = 7.4 × 10(-8)); rs1129406 (12q13) in atf1 (or = 1.11, p = 8...
  47. Chang J, Tian J, Yang Y, Zhong R, Li J, Zhai K, et al. A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer. Cancer Res. 2018;78:5164-5172 pubmed publisher
    ..69-2.57, P = 5.66 × 10-12] and a previous European GWAS-identified 3'-UTR variant in ATF1 (rs11169571, OR = 1.18, 95% CI: 1.13-1.24, P = 1.65 × 10-12)...
  48. Lin J, Zhu J, Wheeldon I. Synthetic Protein Scaffolds for Biosynthetic Pathway Colocalization on Lipid Droplet Membranes. ACS Synth Biol. 2017;6:1534-1544 pubmed publisher
    ..in yeast ester biosynthesis to the native localization of the terminal reaction step, alcohol-O-acetyltransferase (Atf1)...
  49. Guo D, Kong S, Zhang L, Pan H, Wang C, Liu Z. Biosynthesis of advanced biofuel farnesyl acetate using engineered Escherichia coli. Bioresour Technol. 2018;269:577-580 pubmed publisher
    ..coli cells. Then the alcohol acetyltransferase (ATF1) was heterologous overexpressed for the subsequent esterification farnesol to farnesyl acetate...
  50. Pletneva M, Andea A, Palanisamy N, Betz B, Carskadon S, Wang M, et al. Clear cell melanoma: a cutaneous clear cell malignancy. Arch Pathol Lab Med. 2014;138:1328-36 pubmed publisher
    ..demonstrated BRAF V600E mutation, copy gains at the 6p25 (RREB1) and 11q13 (CCND1) loci, and absence of EWSR1-ATF1 fusion. These findings supported a diagnosis of clear cell melanoma...
  51. Takii R, Fujimoto M, Tan K, Takaki E, Hayashida N, Nakato R, et al. ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol. 2015;35:11-25 pubmed publisher
    ..In the present study, we demonstrated that HSF1 interacted with members of the ATF1/CREB family involved in metabolic homeostasis and recruited them on the HSP70 promoter in response to heat shock...
  52. Asada R, Takemata N, Hoffman C, Ohta K, Hirota K. Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor. Mol Cell Biol. 2015;35:847-55 pubmed publisher
    ..First, Tup11/12 inhibit chromatin remodeling in the fbp1⁺ promoter region where the Atf1 and Rst2 transcriptional activators bind...
  53. Knöfler M, Saleh L, Bauer S, Vasicek R, Griesinger G, Strohmer H, et al. Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts. Endocrinology. 2000;141:3737-48 pubmed
    ..We conclude that differentiation-dependent transcription of the CGalpha gene in villous trophoblasts is mainly governed by increasing expression of AP-2alpha and PKA-dependent phosphorylation of CREB-1 and ATF-1. ..
  54. García J, Jin L, Jackson S, Larsen B, Lewis J, Sukov W, et al. Primary pulmonary hyalinizing clear cell carcinoma of bronchial submucosal gland origin. Hum Pathol. 2015;46:471-5 pubmed publisher
    ..polymerase chain reaction confirmed the presence of the EWSR1-Activating Transcription Factor 1 (ATF1) fusion transcript, which was subsequently sequenced...
  55. Venkatesan R, Shim W, Yeo E, Kim S. Lactucopicrin potentiates neuritogenesis and neurotrophic effects by regulating Ca2+/CaMKII/ATF1 signaling pathway. J Ethnopharmacol. 2017;198:174-183 pubmed publisher
    ..It further activates transcription factor 1 (ATF1) along with modulating the levels of tropomyosin receptor kinase A, extracellular signal-regulated kinase 1 and 2, ..
  56. Rangaraju S, Dammer E, Raza S, Rathakrishnan P, Xiao H, Gao T, et al. Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease. Mol Neurodegener. 2018;13:24 pubmed publisher
    ..DAM expressed phagocytic genes (Igf1, Apoe, Myo1e), surface marker CXCR4 with distinct regulators (LXRα/β, Atf1). As neuro-immunomodulatory strategies, we validated LXRα/β agonism and Kv1...
  57. Zhang R, Li G, Jiang D, Zhang D, Yu B, Yang L. [Transcription factors analysis of subchondral bone in early experimental osteoarthritis based on gene expression profiles]. Zhongguo Gu Shang. 2018;31:165-169 pubmed publisher
    ..2)12 TFs, including ARID3A, YY1, RDBP, ATF1, CRX, TAF1, XBP1, SOX3, E2F4, PGR, TIMM8A and HOXA2, were identified as the potential master TFs of down-regulated ..
  58. Glick Y, Orenstein Y, Chen D, Avrahami D, Zor T, Shamir R, et al. Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities. Nucleic Acids Res. 2016;44:e51 pubmed publisher
    ..A single run is equivalent to 4096 gel-shift experiments. Using QPID, we characterized the different affinities of ATF1, c-Jun, c-Fos and AP-1 to the CRE consensus motif and CRE half-site in two different genomic sequences on a single ..
  59. Jimenez Ferrer E, Santillán Urquiza M, Alegría Herrera E, Zamilpa A, Noguerón Merino C, Tortoriello J, et al. Anxiolytic effect of fatty acids and terpenes fraction from Aloysia triphylla: Serotoninergic, GABAergic and glutamatergic implications. Biomed Pharmacother. 2017;96:320-327 pubmed publisher
    ..Also, different fractions obtained from the AtD were evaluated (AtF1, AtF2 and AtF3, 15mg/kg), and showed that fraction AtF1 possessed the anxiolytic activity, in the same model...
  60. Lee Sherick A, Eisenman K, Sather S, McGranahan A, Armistead P, McGary C, et al. Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia. Oncogene. 2013;32:5359-68 pubmed publisher
    ..of prosurvival and proliferative signaling pathways, including phosphorylation of ERK1/2, p38, MSK1, CREB, ATF1, AKT and STAT6...
  61. García P, Paulo E, Gao J, Wahls W, Ayté J, Lowy E, et al. Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription. Nucleic Acids Res. 2014;42:10351-9 pubmed publisher
    ..large transcriptional response common to several stress conditions, regulated primarily by the transcription factor Atf1. Atf1-dependent promoters contain especially broad nucleosome depleted regions (NDRs) prior to stress imposition...
  62. Bohelay G, Kluger N, Battistella M, Biaggi Frassati A, Plantier F, Harraudeau A, et al. [Angiomatoid fibrous histiocytoma in children: 6 cases]. Ann Dermatol Venereol. 2015;142:541-8 pubmed publisher
    ..Tumours were positive for desmin, CD68, CD99 and smooth-muscle actin markers. A fusion gene (EWSR1-ATF1) was found in the 3 cases in which molecular investigation was performed...
  63. García P, Encinar del Dedo J, Ayté J, Hidalgo E. Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS. J Biol Chem. 2016;291:790-9 pubmed publisher
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    ..ABS caused significant increases in the level of activation of the following transcription factors; AP2, AR, CRE/ATF1, CREB, E2F1-5, E2F6, EGR, GATA, HNF-1, ISRE, Myc-Max, NF-1, NFkB, p53, PPAR, SMAD 2/3, SP1, TRE/AP1, and YY1...
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    ..in their location in the gastrointestinal tract, median tumour size and proportion of cases with an EWSR1-ATF1 vs EWSR1-CREB1 fusion. Median survival for CCS-GIT was 13.5 months and for GNET, 9.5 months (p = 0.78)...
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    ..The ATF1-encoded alcohol acetyl coenzyme A (acetyl-CoA) transferase (AATase) is responsible for the majority of acetate ..
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    ..cells' proliferation ability was analyzed through MTT; real-time PCR detected the change of MLK3/MKK6/p38MAPK/MSK1/ATF1 on mRNA, and the difference of protein expression of MKK6/p38MAPK were detected through the Western blotting...
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    ..of cases presents a characteristic reciprocal translocation t(12;22)(q13;q12) that results in fusion of the EWS and ATF1 genes. Although the melanocytic differentiation of CCS is indisputable, its precise lineage remains unclear...
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    Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland tumor with a specific EWSR1-ATF1 fusion gene and can have mucin production. Mucoepidermoid carcinoma (MEC) with a clear cell component is its morphologic mimic...
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    ..Immunohistochemically, tumor cells were positive for CK7, CK5/6, p40, p63, and ATF1, while they were negative for TTF1, Napsin A, HMB45, and SOX10...
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    ..miRNAs obtained from the analysis are: MYST3 and ZNF771 as TFs (for human intra-species analysis), BAZ2B, RCOR3 and ATF1 as TFs (for rhesus intra-species analysis), and mml-miR-768-3p and mml-miR-561 as miRs (for rhesus intra-species ..
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    ..among which 8 up-regulated (Flna, Msn, Cfp, Col4a5, Mum1l1, Rnf128, Syn1, and Srpx2) and 23 down-regulated (Abcb7, Atf1, Ddx26b, Drp2, Fam122b, Gyk, Irak1, Lamp2, Mecp2, Ndufb11, Ogt, Pdha1, Pola1, Rab9, Rbmx2, Rhox9, Thoc2, Vbp1, Dkc1,..
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    ..Various mutants have been constructed to investigate the interactions of ATF1 overexpression, IAH1 deletion, and BAT2 deletion on the production of acetate esters and higher alcohols...
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    ..The hallmark of CCSLTGT is the presence of EWSR1-CREB1 or EWSR1-ATF1 gene fusions, detectable with reverse transcription-polymerase chain reaction (PCR)...
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    ..Moreover, induction of POSH brought apoptotic cell death to KAS, the clear cell sarcoma (CCS) cell line, suggesting that repressed expression of POSH in CCS may be relevant to the normal signaling pathway in apoptosis. ..
  86. Malm H, Mollet I, Berggreen C, Orho Melander M, Esguerra J, Göransson O, et al. Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting β-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases. Mol Cell Endocrinol. 2016;424:23-33 pubmed publisher
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  87. Vilaboa N, Boré A, Martin Saavedra F, Bayford M, Winfield N, Firth Clark S, et al. New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival. Nucleic Acids Res. 2017;45:5797-5817 pubmed publisher
    ..and specific DNA binding but inhibited the transcriptional activity of human HSF1, interfering with the assembly of ATF1-containing transcription complexes...
  88. Desmeules P, Joubert P, Zhang L, Al Ahmadie H, Fletcher C, Vakiani E, et al. A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions. Am J Surg Pathol. 2017;41:980-988 pubmed publisher
    ..We recently encountered 2 MM cases with EWSR1-ATF1 fusions and sought to investigate the prevalence and clinicopathologic features associated with this abnormality...
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    The ability of activating transcription factor-1 (ATF1) or the cAMP response element-binding protein (CREB) to enhance transcription can be stimulated by increases in intracellular Ca2+ concentrations...
  90. Quesada García A, Encinas P, Valdehita A, Baumann L, Segner H, Coll J, et al. Thyroid active agents T3 and PTU differentially affect immune gene transcripts in the head kidney of rainbow trout (Oncorynchus mykiss). Aquat Toxicol. 2016;174:159-68 pubmed publisher
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