Gene Symbol: asporin
Description: asporin
Alias: OS3, PLAP-1, PLAP1, SLRR1C, asporin, asporin (LRR class 1), asporin proteoglycan, periodontal ligament associated protein 1, small leucine-rich protein 1C
Species: human
Products:     asporin

Top Publications

  1. Lorenzo P, Aspberg A, Onnerfjord P, Bayliss M, Neame P, Heinegard D. Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan. J Biol Chem. 2001;276:12201-11 pubmed
    b>Asporin, a novel member of the leucine-rich repeat family of proteins, was partially purified from human articular cartilage and meniscus...
  2. Valdes A, Loughlin J, Oene M, Chapman K, Surdulescu G, Doherty M, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum. 2007;56:137-46 pubmed
    ..02). Our results indicate that genetic polymorphisms affecting knee OA vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, FRZB, and COL2A1 in Caucasians. ..
  3. Song Y, Cheung K, Ho D, Poon S, Chiba K, Kawaguchi Y, et al. Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet. 2008;82:744-7 pubmed publisher
    ..Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA)...
  4. Song J, Lee H, Kim C, Cho Y, Park Y, Nam S, et al. Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population. Knee. 2008;15:191-5 pubmed publisher
    ..that susceptibility to OA is affected by the number of aspartic acid (D) residues in the amino-terminal of the asporin protein...
  5. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, et al. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet. 2005;37:138-44 pubmed
    Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with osteoarthritis, in the ..
  6. Atif U, Philip A, Aponte J, Woldu E, Brady S, Kraus V, et al. Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. Osteoarthritis Cartilage. 2008;16:1174-7 pubmed publisher
    An association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (d) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations...
  7. Kou I, Nakajima M, Ikegawa S. Expression and regulation of the osteoarthritis-associated protein asporin. J Biol Chem. 2007;282:32193-9 pubmed
    b>Asporin (ASPN) is a small leucine-rich proteoglycan that is involved in pathological processes of osteoarthritis...
  8. Shi D, Nakamura T, Dai J, Yi L, Qin J, Chen D, et al. Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population. J Hum Genet. 2007;52:664-7 pubmed
    Recent genetic studies for osteoarthritis (OA) have been focused on ASPN, the gene encoding asporin, where aspartic acid (D)-repeat polymorphisms are associated with OA in several ethnic groups...
  9. Turtoi A, Musmeci D, Wang Y, Dumont B, Somja J, Bevilacqua G, et al. Identification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma. J Proteome Res. 2011;10:4302-13 pubmed publisher
    ..transforming growth factor beta-induced (TGFBI), latent transforming growth factor beta binding 2 (LTBP2), and asporin (ASPN) were further investigated by employing large scale immunohistochemistry-based validations...

More Information


  1. Nakamura T, Shi D, Tzetis M, Rodriguez Lopez J, Miyamoto Y, Tsezou A, et al. Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum Mol Genet. 2007;16:1676-81 pubmed
    ..It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated with OA of knee and hip joints in Japanese; in the three independent studies performed, the ..
  2. Kalamajski S, Aspberg A, Lindblom K, Heinegard D, Oldberg A. Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization. Biochem J. 2009;423:53-9 pubmed publisher
    The interactions of the ECM (extracellular matrix) protein asporin with ECM components have previously not been investigated. Here, we show that asporin binds collagen type I...
  3. Shi D, Dai J, Zhu P, Qin J, Zhu L, Zhu H, et al. Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Arthritis Res Ther. 2011;13:R27 pubmed publisher
    ..Genetic factors play a considerable role in the etiology of DDH. Asporin (ASPN) is an ECM protein which can bind to TGF-?1 and sequentially inhibit TGF-?/Smad signaling...
  4. Rodriguez Lopez J, Pombo Suarez M, Liz M, Gomez Reino J, Gonzalez A. Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Arthritis Res Ther. 2006;8:R55 pubmed
    A recent genetic association study has identified a microsatellite in the coding sequence of the asporin gene as a susceptibility factor for osteoarthritis (OA)...
  5. Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S. Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem. 2007;282:32185-92 pubmed
    ..Recently, we demonstrated a genetic association between the cartilage extracellular matrix protein asporin and OA (Kizawa, H., Kou, I., Iida, A., Sudo, A., Miyamoto, Y., Fukuda, A., Mabuchi, A., Kotani, A., Kawakami, A...
  6. Jiang Q, Shi D, Yi L, Ikegawa S, Wang Y, Nakamura T, et al. Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese. J Hum Genet. 2006;51:1068-72 pubmed
    A genetic association of osteoarthritis (OA) and functional polymorphisms in the aspartic acid (D) repeat of the asporin gene was reported in Japanese and European Caucasians; however, the results were controversial...
  7. Torres B, Orozco G, Garcia Lozano J, Oliver J, Fernandez O, Gonzalez Gay M, et al. Asporin repeat polymorphism in rheumatoid arthritis. Ann Rheum Dis. 2007;66:118-20 pubmed
    b>Asporin belongs to a family of proteins associated with the cartilage matrix...
  8. Mustafa Z, Dowling B, Chapman K, Sinsheimer J, Carr A, Loughlin J. Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. Arthritis Rheum. 2005;52:3502-6 pubmed
    ..genetic association with osteoarthritis (OA) of 2 functional alleles in the aspartic acid (D) repeat of the asporin gene was recently reported in a Japanese population...
  9. Henry S, Takanosu M, Boyd T, Mayne P, Eberspaecher H, Zhou W, et al. Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family. J Biol Chem. 2001;276:12212-21 pubmed
    ..For this reason, we called the molecule asporin. The deduced amino acid sequence is about 50% identical (and 70% similar) to decorin and biglycan...
  10. Li H, Zhang Z, Chen L, Sun X, Zhao Y, Guo Q, et al. Cytoplasmic Asporin promotes cell migration by regulating TGF-β/Smad2/3 pathway and indicates a poor prognosis in colorectal cancer. Cell Death Dis. 2019;10:109 pubmed publisher
    Previous studies revealed that Asporin (ASPN) is a potential mediator in the development of various types of cancer as a secreted stroma protein, but the function of ASPN inside the cancer cells remains largely unknown...
  11. Dudakovic A, Camilleri E, Riester S, Lewallen E, Kvasha S, Chen X, et al. High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells. J Cell Biochem. 2014;115:1816-28 pubmed publisher
    ..Our findings validate the biological properties of self-renewing and multi-potent AMSCs by providing high-resolution quality control data that support their clinical versatility. ..
  12. Kawamura R, Hayashi Y, Murakami H, Nakashima M. EDTA soluble chemical components and the conditioned medium from mobilized dental pulp stem cells contain an inductive microenvironment, promoting cell proliferation, migration, and odontoblastic differentiation. Stem Cell Res Ther. 2016;7:77 pubmed publisher
    ..hormone degrading enzyme (TRH-DE), was lower, and expression of a periodontal cell marker, anti-asporin/periodontal ligament-associated protein 1 (PLAP-1), was higher in the transplant of the EDTA-extracted teeth ..
  13. Yu X, Sun J, Hu Y, Gao Y, Xiao C, Liu S, et al. Overexpression of PLAP-1 in bone marrow stromal cells inhibits the rat critical-size skull defect repair. J Mol Histol. 2015;46:251-61 pubmed publisher
    ..Overexpression of PLAP-1 in rBMSCs inhibits new bone formation and mineralization in rat critical-size skull defects in vivo. ..
  14. Ueda M, Goto T, Kuroishi K, Gunjigake K, Ikeda E, Kataoka S, et al. Asporin in compressed periodontal ligament cells inhibits bone formation. Arch Oral Biol. 2016;62:86-92 pubmed publisher
    ..and inhibition of bone formation on the compressed side by secreting bone-formation inhibitory factors such as asporin (ASPN) or sclerostin (encoded by SOST)...
  15. Yu X, Liu H, Li C, Du Y, Du Y, Zhang S. Periodontal ligament-associated protein-1 gets involved in the development of osseous eruption canal. J Mol Histol. 2019;50:35-42 pubmed publisher
    ..The role of periodontal ligament-associated protein-1 (PLAP-1/asporin) in the development of osseous eruption canal remain undefined and were the focus of this study...
  16. Moscatiello R, Zaccarin M, Ercolin F, Damiani E, Squartini A, Roveri A, et al. Identification of ferredoxin II as a major calcium binding protein in the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. BMC Microbiol. 2015;15:16 pubmed publisher
    ..The present data indicate that ferredoxin II is a major Ca(2+) binding protein in M. loti that may participate in Ca(2+) homeostasis and suggest an evolutionarily ancient origin for protein-based Ca(2+) regulatory systems. ..
  17. Yamada S, Murakami S, Matoba R, Ozawa Y, Yokokoji T, Nakahira Y, et al. Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene. Gene. 2001;275:279-86 pubmed
    ..These findings suggest the involvement of PLAP-1 in the mineralized matrix formation in PDL tissues. ..
  18. Yamaba S, Yamada S, Kajikawa T, Awata T, Sakashita H, Tsushima K, et al. PLAP-1/Asporin Regulates TLR2- and TLR4-induced Inflammatory Responses. J Dent Res. 2015;94:1706-14 pubmed publisher
    Periodontal ligament-associated protein 1 (PLAP-1)/asporin is an extracellular matrix protein preferentially expressed in periodontal ligaments...
  19. Sekimoto T, Ishii M, Emi M, Kurogi S, Funamoto T, Yonezawa Y, et al. Copy number loss in the region of the ASPN gene in patients with acetabular dysplasia: ASPN CNV in acetabular dysplasia. Bone Joint Res. 2017;6:439-445 pubmed publisher associated with a genetic polymorphism in the aspartic acid repeat in the N-terminal region of the asporin (ASPN) gene; therefore, the present study aimed to investigate whether the CNV of ASPN is involved ..
  20. Heppner J, Zaucke F, Clarke L. Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I. Mol Genet Metab. 2015;114:146-55 pubmed publisher
    ..These findings have important therapeutic implications. ..
  21. Mikurova A, Novikova S, Skvortsov V, Alekseychuk N, Rybina A, Miroshnichenko Y. [The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins]. Biomed Khim. 2017;63:397-404 pubmed publisher
    ..The degree of sequence coverage was not at least 40%, and in the best cases it reached 80-90%. The use of de novo sequencing software resulted in identification of the Y12H amino acid substitution in one model protein (CYB5A)...
  22. Hatzirodos N, Hummitzsch K, Irving Rodgers H, Rodgers R. Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles. PLoS ONE. 2015;10:e0119800 pubmed publisher
    ..Many of these were stromal extracellular matrix genes. MGARP, GLDC, CHST8, GPX3 were identified as new potential markers for granulosa cells, while FBLN5, OGN, RAMP2 were significantly elevated in the theca interna. ..
  23. Riley N, Rush M, Rose C, Richards A, Kwiecien N, Bailey D, et al. The Negative Mode Proteome with Activated Ion Negative Electron Transfer Dissociation (AI-NETD). Mol Cell Proteomics. 2015;14:2644-60 pubmed publisher
  24. Li L, Yang Y, Yue S, Bai Y. [Effect of light centrifugal force on the asporin gene expression in human periodontal ligament cells]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2014;49:304-7 pubmed
    To observe the expression of asporin, bone morphogenetic protein-2 (BMP-2) and alkaline phosphatase (ALP) in cultured human periodontal ligament cells in vitro under relative centrifugal force...
  25. Arellano R, Hernandez F, García Sepúlveda C, Velasco V, Loera C, Arguello J. The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case-control study. J Orthop Sci. 2013;18:826-31 pubmed publisher
    A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and ..
  26. Tai Z, Huang L, Lu F, Shi Y, Ma S, Cheng J, et al. Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population. BMC Med Genet. 2017;18:69 pubmed publisher
    ..Moreover, genetic variants in chondrogenesis-related genes COL10A1 and HABP2 may play a role in the risk of developing KBD in the Tibetan population. ..
  27. Gao J, Li Y, Wang T, Shi Z, Zhang Y, Liu S, et al. Analyzing Gene Expression Profiles with Preliminary Validations in Cardiac Hypertrophy Induced by Pressure-overload. Can J Physiol Pharmacol. 2018;: pubmed publisher
    ..The current study identified the key deregulated genes and pathways involved in the CH, which could shed new light to understand the mechanism of CH. ..
  28. Kajikawa T, Yamada S, Tauchi T, Awata T, Yamaba S, Fujihara C, et al. Inhibitory effects of PLAP-1/asporin on periodontal ligament cells. J Dent Res. 2014;93:400-5 pubmed publisher
    PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region...
  29. Salmon C, Giorgetti A, Paes Leme A, Domingues R, Sallum E, Alves M, et al. Global proteome profiling of dental cementum under experimentally-induced apposition. J Proteomics. 2016;141:12-23 pubmed publisher
    ..EIA and time (12 proteins), including serpin 1a, procollagen C-endopeptidase enhancer, tenascin X (TNX), and asporin (ASPN)...
  30. Uehara H, Luo S, Aryal B, Levine R, Rao V. Distinct oxidative cleavage and modification of bovine [Cu- Zn]-SOD by an ascorbic acid/Cu(II) system: Identification of novel copper binding site on SOD molecule. Free Radic Biol Med. 2016;94:161-73 pubmed publisher
  31. Salmon C, Giorgetti A, Paes Leme A, Domingues R, Kolli T, Foster B, et al. Microproteome of dentoalveolar tissues. Bone. 2017;101:219-229 pubmed publisher
    ..ECM proteins including collagen alpha-1(I) chain (COL1A1), collagen alpha-1(XII) chain (COL12A1), biglycan (BGN), asporin (ASPN), lumican (LUM), and fibromodulin (FMOD), served to validate the approach...
  32. Kraemer M, Sandoval Garcia C, Bragg T, Iskandar B. Shunt-dependent hydrocephalus: management style among members of the American Society of Pediatric Neurosurgeons. J Neurosurg Pediatr. 2017;20:216-224 pubmed publisher
    ..Such discrepancies appear to be derived partly from inconsistent familiarity with existing literature but especially from a paucity of high-quality publications. ..
  33. Luehders K, Sasai N, Davaapil H, Kurosawa Yoshida M, Hiura H, Brah T, et al. The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway. Development. 2015;142:3351-61 pubmed publisher
    ..Here, we demonstrate that the SLRP family member Asporin (ASPN) plays a crucial role in the early stages of eye development in Xenopus embryos...
  34. Chand D, Swartz S, Tuchman S, Valentini R, Somers M. Dialysis in Children and Adolescents: The Pediatric Nephrology Perspective. Am J Kidney Dis. 2017;69:278-286 pubmed publisher
    ..Endorsed by the Council of the American Society of Pediatric Nephrology (ASPN), this position paper serves as a reference tool for the provision of care to pediatric patients with ESRD. ..
  35. Juchtmans N, Dhollander A, Coudenys J, Audenaert E, Pattyn C, Lambrecht S, et al. Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage. Arthritis Rheumatol. 2015;67:435-41 pubmed
    ..We specifically focused on 3 small leucine-rich repeat proteins (SLRPs), osteomodulin, osteoglycin, and asporin, that appeared to be distinctly regulated in OA labrum compared to OA cartilage...
  36. Ribeiro I, Leclercq C, Simoes N, Toureiro A, Duarte I, Freire J, et al. Identification of chickpea seed proteins resistant to simulated in vitro human digestion. J Proteomics. 2017;169:143-152 pubmed publisher
  37. Bijsterbosch J, Kloppenburg M, Reijnierse M, Rosendaal F, Huizinga T, Slagboom P, et al. Association study of candidate genes for the progression of hand osteoarthritis. Osteoarthritis Cartilage. 2013;21:565-9 pubmed publisher
    ..Since OA progression is clinically the most relevant phenotype, we investigate the association between asporin (ASPN), bone morphogenetic protein 5 (BMP5) and growth differentiation factor 5 (GDF5) polymorphisms and ..
  38. Ding Q, Zhang M, Liu C. Asporin participates in gastric cancer cell growth and migration by influencing EGF receptor signaling. Oncol Rep. 2015;33:1783-90 pubmed publisher
    b>Asporin (ASPN), a novel member of the small leucine-rich proteoglycan (SLRP) family, serves as a key component of the tumor stroma and has been reported to be abnormally expressed in certain types of tumors...
  39. Song G, Kim J, Lee Y. A meta-analysis of the relationship between aspartic acid (D)-repeat polymorphisms in asporin and osteoarthritis susceptibility. Rheumatol Int. 2014;34:785-92 pubmed publisher
    Our aim was to determine whether asporin (ASPN) D-repeat polymorphisms are associated with susceptibility to osteoarthritis (OA)...
  40. Wu H, Jing X, Cheng X, He Y, Hu L, Wu H, et al. Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway. Oncotarget. 2016;7:73402-73413 pubmed publisher
    b>Asporin has been implicated as an oncogene in various types of human cancers; however, the roles of asporin in the development and progression of colorectal cancer (CRC) have not yet been determined...
  41. Yim S, Yoon D, Park M, Lee I, Kim J, Lee M, et al. Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance. BMC Med Genomics. 2013;6 Suppl 2:S10 pubmed publisher
    ..Furthermore, the CMT-related protein network modules were identified, which provided more in-depth understanding of pathophysiology of CMT. ..
  42. Mayer J, Iatridis J, Chan D, Qureshi S, Gottesman O, Hecht A. Genetic polymorphisms associated with intervertebral disc degeneration. Spine J. 2013;13:299-317 pubmed publisher
    ..hyaluronan and proteoglycan link protein 1 (HAPLN1), thrombospondin, cartilage intermediate layer protein (CILP), asporin, MMP1, 2, and 3, parkinson protein 2, E3 ubiquitin protein ligase (PARK2), proteosome subunit ? type 9 (PSMB9), ..
  43. Tian W, Zheng S, Jiang X, Wu C, Wang N, Zhao D. Asporin, a candidate protein for treatment of disc degenerative disease. Chin Med J (Engl). 2013;126:369-72 pubmed
  44. Arellano Pérez Vertti R, Argüello Astorga J, Cortéz López M, Zamarripa Mottú J, García Salcedo J, Luna Ceniceros D. [D-repeat polymorphism in the ASPN gene in knee osteoarthritis in females in Torreón, Coahuila. Case-control study]. Acta Ortop Mex. 2014;28:363-8 pubmed analyze the relationship between primary knee osteoarthritis and the D-repeat polymorphism in the ASPN gene (asporin). 130 females with knee osteoarthritis and 130 healthy female controls were included...
  45. Klee E, Bondar O, Goodmanson M, Dyer R, Erdogan S, Bergstralh E, et al. Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood. Clin Chem. 2012;58:599-609 pubmed publisher
    ..concentrations in blood from men with advanced prostate adenocarcinoma compared with controls: apolipoprotein C1, asporin, cartilage oligomeric matrix protein, chemokine (C-X-C motif) ligand 11 (CXCL11), CXCL9, coagulation factor V, ..
  46. Jazayeri R, Qoreishi M, Hoseinzadeh H, Babanejad M, Bakhshi E, Najmabadi H, et al. Investigation of the asporin gene polymorphism as a risk factor for knee osteoarthritis in Iran. Am J Orthop (Belle Mead NJ). 2013;42:313-6 pubmed
    ..The asporin (ASPN) gene encodes a cartilage extracellular protein belonging to the small leucine-rich proteoglycan family...
  47. Minafra L, Bravatà V, Saporito M, Cammarata F, Forte G, Caldarella S, et al. Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility. Arthritis Res Ther. 2014;16:R91 pubmed publisher
  48. Eskola P, Lemmelä S, Kjaer P, Solovieva S, Männikkö M, Tommerup N, et al. Genetic association studies in lumbar disc degeneration: a systematic review. PLoS ONE. 2012;7:e49995 pubmed publisher
    ..Clear definition of lumbar disc degeneration phenotypes and large population-based cohorts are needed. An international consortium is needed to standardize genetic association studies in relation to disc degeneration. ..
  49. Fuentes Duculan J, Bonifacio K, Suárez Fariñas M, Kunjravia N, Garcet S, Cruz T, et al. Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans. Exp Dermatol. 2017;26:721-727 pubmed publisher
    ..and NL skin are involved in bone/cartilage formation including Fibrillin 2 (FBN2), Collagen type X alpha 1, Asporin (ASPN), Cadherin 11 (CDH11), Bone morphogenic protein 1 (BMP1), Secreted phosphoprotein 1 and Runt-related ..
  50. Liu R, Yuan X, Yu J, Quan Q, Meng H, Wang C, et al. An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity. J Orthop Surg Res. 2017;12:148 pubmed publisher
    ..Although pathology of KOA remains unknown, genetic factors are considered to be the major cause. Asporin is a group of biologically active components of extracellular matrix (ECM) in articular cartilage, and asporin ..
  51. Gruber H, Ingram J, Hoelscher G, Zinchenko N, Hanley E, Sun Y. Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc. Arthritis Res Ther. 2009;11:R47 pubmed publisher
    b>Asporin, also known as periodontal ligament-associated protein 1 (PLAP1), is a member of the family of small leucine-rich proteoglycan (SLRP) family...
  52. Shi C, Uda Y, Dedic C, Azab E, Sun N, Hussein A, et al. Carbonic anhydrase III protects osteocytes from oxidative stress. FASEB J. 2018;32:440-452 pubmed publisher
    ..Uda, Y., Dedic, C., Azab, E., Sun, N., Hussein, A. I., Petty, C. A., Fulzele, K., Mitterberger-Vogt, M. C., Zwerschke, W., Pereira, R., Wang, K., Divieti Pajevic, P. Carbonic anhydrase III protects osteocytes from oxidative stress. ..
  53. Simkova D, Kharaishvili G, Korinkova G, Ozdian T, Suchánková Kleplová T, Soukup T, et al. The dual role of asporin in breast cancer progression. Oncotarget. 2016;7:52045-52060 pubmed publisher
    b>Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer...
  54. Wang L, Wu H, Wang L, Zhang H, Lu J, Liang Z, et al. Asporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms. Cancer Lett. 2017;398:24-36 pubmed publisher
    ..b>Asporin, an extracellular matrix (ECM) protein, is highly expressed in cancer-associated fibroblasts (CAFs)...
  55. Xing D, Ma X, Ma J, Xu W, Wang J, Yang Y, et al. Association between aspartic acid repeat polymorphism of the asporin gene and susceptibility to knee osteoarthritis: a genetic meta-analysis. Osteoarthritis Cartilage. 2013;21:1700-6 pubmed publisher
    ..that susceptibility to KOA is affected by the number of aspartic acid (D) residues in the amino-terminal of the asporin protein, but evidence remains conflicting...
  56. Castellana B, Escuin D, Peiro G, García Valdecasas B, Vázquez T, Pons C, et al. ASPN and GJB2 Are Implicated in the Mechanisms of Invasion of Ductal Breast Carcinomas. J Cancer. 2012;3:175-83 pubmed publisher
    ..The association of GJB2 protein expression with invasion was confirmed by qRT-PCR in mouse tumors (P < 0.05). The upregulation of ASPN and GJB2 may play important roles in local invasion of breast ductal carcinomas. ..
  57. Yu X, Liu S, Wang W, Li S. Periodontal ligament?associated protein?1 delays rat periodontal bone defect repair by regulating osteogenic differentiation of bone marrow stromal cells and osteoclast activation. Int J Mol Med. 2018;41:1110-1118 pubmed publisher
    ..01). In conclusion, the present study found that PLAP?1 delays rat periodontal bone defect repair by inhibiting osteogenic differentiation and promoting osteoclast activation, mainly dependent on the upregulation of the RANKL/OPG ratio...
  58. Liao W, Okada M, Sakamoto F, Okita N, Inami K, Nishiura A, et al. In vitro human periodontal ligament-like tissue formation with porous poly-L-lactide matrix. Mater Sci Eng C Mater Biol Appl. 2013;33:3273-80 pubmed publisher
    ..The results indicated in vitro HPdLLT formation, and it could be used in future periodontal ligament tissue engineering to achieve optimal periodontal regeneration. ..
  59. Zhu F, Friedman M, Luo W, Woolf P, Hankenson K. The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation. J Cell Physiol. 2012;227:2677-85 pubmed publisher
    ..genes, including bone sialoprotein (BSP) and a novel set of proteoglycans, osteomodulin (OMD), osteoglycin, and asporin. Maximum expression of these genes is dependent upon both the concentration and duration of BMP6 exposure...
  60. Poulou M, Kaliakatsos M, Tsezou A, Kanavakis E, Malizos K, Tzetis M. Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin. Genet Test. 2008;12:263-5 pubmed publisher
    ..implied that the -16TT (rs12885713) CALM1 core promoter genotype is not a risk factor for OA etiology in Greek Caucasians on its own, but associated with the Asporin (ASPN) D14 or D15 risk allele, it could influence KOA susceptibility.
  61. Sobhan M, Mehdinejad M, Jamaladini M, Mazaheri M, Zare Shehneh M, Neamatzadeh H. Association between aspartic acid repeat polymorphism of the asporin gene and risk of knee osteoarthritis: A systematic review and meta-analysis. Acta Orthop Traumatol Turc. 2017;51:409-415 pubmed publisher
    Studies have assessed the association between aspartic acid (D)-repeat polymorphism in the gene encoding Asporin (ASPN) and knee osteoarthritis (KOA) risk, but the results were inconclusive and contradictory...
  62. Juneja S, Veillette C. Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review. Arthritis. 2013;2013:154812 pubmed publisher
    ..The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small ..
  63. Avila Martin G, Mata Roig M, Galán Arriero I, Taylor J, Busquets X, Escriba P. Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation. PLoS ONE. 2017;12:e0189151 pubmed publisher
    ..Currently, SCI has very important unmet clinical needs. A-HOA downregulated genes involved with inflammation and upregulated genes involved in neuronal growth, and may serve to promote recovery of function after experimental SCI...
  64. Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, Murakami S. Regulation of PLAP-1 expression in periodontal ligament cells. J Dent Res. 2006;85:447-51 pubmed
    ..These results revealed the cytokine-mediated regulatory mechanisms of PLAP-1 expression and suggested that PLAP-1 expression may be associated with the process of cytodifferentiation of PDL cells. ..
  65. Taipale M, Solovieva S, Leino Arjas P, Männikkö M. Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis. BMC Genet. 2017;18:108 pubmed publisher
    ..of this study was to examine the association of two known functional polymorphisms in the TGF-? inhibiting genes, asporin (ASPN) and cartilage intermediate layer protein (CILP), with hand OA and potential gene-occupational hand loading ..
  66. Rochette A, Boufaied N, Scarlata E, Hamel L, Brimo F, Whitaker H, et al. Asporin is a stromally expressed marker associated with prostate cancer progression. Br J Cancer. 2017;116:775-784 pubmed publisher
    ..We have used Kaplan-Meier, univariate and multivariate analysis to correlate the expression of Asporin (ASPN) mRNA and protein with prostate cancer progression in independent cohorts...
  67. Liu D, Yang Q, Li M, Mu K, Zhang Y. Association of an asporin repeat polymorphism with ankylosing spondylitis in Han Chinese population: a case-control study. Clin Invest Med. 2010;33:E63-8 pubmed
    To investigate the role of a functional polymorphism consisting of an aspartic acid (D) repeat located in the asporin gene (ASPN) gene in the susceptibility to and clinical outcome of ankylosing spondylitis (AS)...
  68. Hurng J, Kurylo M, Marshall G, Webb S, Ryder M, Ho S. Discontinuities in the human bone-PDL-cementum complex. Biomaterials. 2011;32:7106-17 pubmed publisher
    ..Narrowed PDL-complexes illustrated patchy appearance of asporin, and when imaged under wet conditions using an atomic force microscope (AFM), demonstrated structural ..
  69. Takahashi H, Nakajima M, Ozaki K, Tanaka T, Kamatani N, Ikegawa S. Prediction model for knee osteoarthritis based on genetic and clinical information. Arthritis Res Ther. 2010;12:R187 pubmed publisher
    ..We genotyped risk alleles of the three susceptibility genes, asporin (ASPN), growth differentiation factor 5 (GDF5), and double von Willebrand factor A domains (DVWA) for a total of ..
  70. Hurley P, Sundi D, Shinder B, Simons B, Hughes R, Miller R, et al. Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res. 2016;22:448-58 pubmed publisher
    Prostate cancers incite tremendous morbidity upon metastatic growth. We previously identified Asporin (ASPN) as a potential mediator of metastatic progression found within the tumor microenvironment...
  71. Ansari D, Aronsson L, Sasor A, Welinder C, Rezeli M, Marko Varga G, et al. The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science. J Transl Med. 2014;12:87 pubmed publisher
    ..Examples of candidate biomarkers that have been identified from these pancreas studies include among others, asporin, CD9, CXC chemokine ligand 7, fibronectin 1, galectin-1, gelsolin, intercellular adhesion molecule 1, insulin-..
  72. Ikegawa S. The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. Annu Rev Genomics Hum Genet. 2013;14:245-56 pubmed publisher
    ..two diseases have common susceptibility alleles--namely, the GDF5 rs143383 single-nucleotide polymorphism and the asporin D14 triplet repeat--which provides hints on how to investigate their genetic factors...
  73. Loughlin J. Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip--an emerging genetic overlap. Arthritis Res Ther. 2011;13:108 pubmed publisher
    ..Another interesting example has recently emerged in the repeat polymorphism of the asporin gene, ASPN, which is also associated with these three phenotypes...
  74. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..effects on collagen and extracellular matrix in vivo have been elucidated; one of the less investigated SLRPs is asporin. Here we describe the successful generation of an Aspn-/- mouse model and the investigation of the Aspn-/- skin ..
  75. Liang W, Gao B, Xu G, Weng D, Xie M, Qian Y. Association between single nucleotide polymorphisms of asporin (ASPN) and BMP5 with the risk of knee osteoarthritis in a Chinese Han population. Cell Biochem Biophys. 2014;70:1603-8 pubmed publisher
    The aim of this study was to investigate associations between single nucleotide polymorphisms rs13301537 in asporin (ASPN) and rs373444 in the bone morphogenetic protein 5 (BMP5) gene with knee osteoarthritis (OA) susceptibility in a ..
  76. Ikegawa S. Expression, regulation and function of asporin, a susceptibility gene in common bone and joint diseases. Curr Med Chem. 2008;15:724-8 pubmed
    b>Asporin is an extracellular matrix protein that belongs to the small leucine-rich repeat proteoglycan (SLRP) family of proteins...
  77. Chou C, Lee C, Lu L, Song I, Chuang H, Kuo S, et al. Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees. Osteoarthritis Cartilage. 2013;21:450-61 pubmed publisher
    ..We expect this method to facilitate advances in our understanding of the coordinated molecular responses of the whole joint organ. ..
  78. Sakao K, Takahashi K, Arai Y, Saito M, Honjyo K, Hiraoka N, et al. Asporin and transforming growth factor-beta gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis. J Orthop Sci. 2009;14:738-47 pubmed publisher
    ..of subchondral bone and osteophytes in the pathology of osteoarthritis (OA), we investigated the expression of asporin (ASPN), transforming growth factor-beta1 (TGF-beta1), TGF-beta2, TGF-beta3, and runt-related transcription factor-..
  79. Lee E, Park H, Jeong J, Kim Y, Cha D, Kwon D, et al. The role of asporin in mineralization of human dental pulp stem cells. J Cell Physiol. 2011;226:1676-82 pubmed publisher
    ..In this study, we investigated the role of Asporin in hDPSCs, which was identified as a matrix protein in our previous dentin proteomic analysis...
  80. Duval E, Bigot N, Hervieu M, Kou I, Leclercq S, Galera P, et al. Asporin expression is highly regulated in human chondrocytes. Mol Med. 2011;17:816-23 pubmed publisher
    A significant association between a polymorphism in the D repeat of the gene encoding asporin and osteoarthritis, the most frequent of articular diseases, has been recently reported...
  81. Satoyoshi R, Kuriyama S, Aiba N, Yashiro M, Tanaka M. Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts. Oncogene. 2015;34:650-60 pubmed publisher
    ..Here, we show for the first time that Asporin, a small leucine-rich proteoglycan (SLRP), is predominantly expressed in CAFs, and has essential roles in ..
  82. Zhu X, Jiang L, Lu Y, Wang C, Zhou S, Wang H, et al. Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis. Medicine (Baltimore). 2018;97:e0200 pubmed publisher
    ..For D14 and D15 allele, our present meta-analysis did not demonstrate statistically significant association. Further studies with larger sample size would be required. ..
  83. Li C, Li C, Yue J, Huang X, Chen M, Gao J, et al. miR-21 and miR-101 regulate PLAP-1 expression in periodontal ligament cells. Mol Med Rep. 2012;5:1340-6 pubmed publisher
    Periodontal ligament-associated protein-1 (PLAP-1/asporin) is a special marker in periodontal ligament tissue. It is an important regulator of osteogenic differentiation of periodontal ligament cells (PDLCs)...