ASIC3

Summary

Gene Symbol: ASIC3
Description: acid sensing ion channel subunit 3
Alias: ACCN3, DRASIC, SLNAC1, TNaC1, acid-sensing ion channel 3, acid sensing (proton gated) ion channel 3, amiloride-sensitive cation channel 3, testis, modulatory subunit of ASIC2a, neuronal amiloride-sensitive cation channel 3, proton-gated cation channel subunit, testis sodium channel 1
Species: human
Products:     ASIC3

Top Publications

  1. Farrag M, Drobish J, Puhl H, Kim J, Herold P, Kaufman M, et al. Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. J Physiol. 2017;595:7167-7183 pubmed publisher
    ..Finally, E-2 effects were inhibited by pretreatment with the ASIC3 blocker APETx2 and enhanced by pretreatment with the ASIC1a blocker psalmotoxin-1...
  2. Li M, Leng T, Feng X, Yang T, Simon R, Xiong Z. Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke. J Biol Chem. 2016;291:18370-83 pubmed publisher
    ..that the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits...
  3. Lehmke L, Coburn M, Möller M, Blaumeiser Debarry R, Lenzig P, Wiemuth D, et al. Inhalational anesthetics accelerate desensitization of acid-sensing ion channels. Neuropharmacology. 2018;135:496-505 pubmed publisher
    ..3 ± 5.6 μA (n = 12; p = 0.0009). While inhalational anesthetics had similar effects on homomeric ASIC3, desensitization of ASIC1b was only accelerated by halogenated anesthetics but not noble gases; desensitization of ..
  4. Wang Y, Fu X, Huang L, Wang X, Lu Z, Zhu F, et al. Increased Asics Expression via the Camkii-CREB Pathway in a Novel Mouse Model of Trigeminal Pain. Cell Physiol Biochem. 2018;46:568-578 pubmed publisher
    ..In addition, the relative mRNA and protein expression levels of ASIC1a and ASIC3 were increased in the acid-induced trigeminal nociceptive pathways...
  5. da Silva Oliveira G, de Freitas R. Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. Pharmacol Res. 2015;102:138-57 pubmed publisher
    ..property still little studied is the inhibition of acid-sensitive ion channels (ASIC1a, ASIC1b, ASIC2a and ASIC3), which are related to the development of various diseases...
  6. Kim E, Lee D, Kim Y, Kim M, Kim J, Lee M, et al. Decreased ATP synthesis and lower pH may lead to abnormal muscle contraction and skin sensitivity in human skin. J Dermatol Sci. 2014;76:214-21 pubmed publisher
    ..In addition, pain-related transcripts such as TRPV1, ASIC3 and CGRP were significantly up-regulated in sensitive skin, compared with non-sensitive skin...
  7. Santos P, Guimarães A, Barreto R, Serafini M, Quintans J, Quintans Júnior L. A review of recent patents on the ASICs as a key drug target. Recent Pat Biotechnol. 2015;9:30-41 pubmed
    ..Drugs acting as antagonist in ASIC1 or ASIC3 channels seem to be the most promising targets...
  8. Stone A, Kaufman M. The exercise pressor reflex and peripheral artery disease. Auton Neurosci. 2015;188:69-73 pubmed publisher
    ..Earlier studies have identified ASIC3 channels, bradykinin receptors, P2X receptors, endoperoxide receptors, and thromboxane receptors as playing a role ..
  9. Lin S, Sun W, Chen C. Genetic exploration of the role of acid-sensing ion channels. Neuropharmacology. 2015;94:99-118 pubmed publisher
    ..models used to investigate the physiological function of individual ASIC subtypes: ASIC1 (and ASIC1a), ASIC2, ASIC3 and ASIC4...

More Information

Publications137 found, 100 shown here

  1. So E, Wang Y, Yang L, So K, Lo Y, Wu S. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons. Biochem Pharmacol. 2018;151:79-88 pubmed publisher
    ..Taken together, findings from these results indicated that in addition to the activation of ASIC3 channels, this compound might directly produce additional actions on various types of ion channels...
  2. Lee J, Saez N, Cristofori Armstrong B, Anangi R, King G, Smith M, et al. Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. Br J Pharmacol. 2017;: pubmed publisher
    Acid-sensing ion channels (ASICs) are primary acid sensors in mammals, with the ASIC1b and ASIC3 subtypes being involved in peripheral nociception...
  3. Shteinikov V, Potapieva N, Gmiro V, Tikhonov D. Hydrophobic Amines and Their Guanidine Analogues Modulate Activation and Desensitization of ASIC3. Int J Mol Sci. 2019;20: pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) is an important member of the acid-sensing ion channels family, which is widely expressed in the peripheral nervous system and contributes to pain sensation...
  4. Munro G, Christensen J, Erichsen H, Dyhring T, Demnitz J, Dam E, et al. NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neurosci Ther. 2016;22:135-45 pubmed publisher
    ..NS383 inhibited H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM...
  5. Ren P, Wang W, Pan H, Qiu C, Hu W. Up-regulation of ASIC3 expression by β-estradiol. Neurosci Lett. 2018;684:200-204 pubmed publisher
    ..We report here17β-estradiol (E2) up-regulates expression of acid-sensing ion channel 3 (ASIC3), which can mediate the acidosis-induced events. The recombinant plasmid of pCDNA3.1-ASIC3-GFP and pCDNA3...
  6. Vyvers A, Schmidt A, Wiemuth D, Grunder S. Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators. Sci Rep. 2018;8:18000 pubmed publisher
    Acid-sensing ion channels (ASICs) belong to the DEG/ENaC gene family. While ASIC1a, ASIC1b and ASIC3 are activated by extracellular protons, ASIC4 and the closely related bile acid-sensitive ion channel (BASIC or ASIC5) are orphan ..
  7. Zaremba M, Ruiz Velasco V. Opioid-mediated modulation of acid-sensing ion channel (ASIC) currents in adult rat sensory neurons. Mol Pharmacol. 2019;: pubmed publisher
    ..and the semi-synthetic opioid (oxycodone) would also potentiate sustained ASIC currents, which arise from ASIC3 channel isoforms...
  8. Garcia G, Gutiérrez Lara E, Centurión D, Granados Soto V, Murbartián J. Fructose-Induced Insulin Resistance as a Model of Neuropathic Pain in Rats. Neuroscience. 2019;404:233-245 pubmed publisher
    ..Chronic fructose also increased anoctamin-1 and ASIC3 whereas it reduced insulin receptor-β, α5GABAA receptors and TASK-3 channels protein ..
  9. Lee C, Chen C. Roles of ASICs in Nociception and Proprioception. Adv Exp Med Biol. 2018;1099:37-47 pubmed publisher
    ..There are at least six ASIC subtypes - ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, and ASIC4 - all expressed in somatosensory neurons...
  10. Ashwell M, Freire M, O Nan A, Benito J, Hash J, McCulloch R, et al. Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain. Vet J. 2019;243:42-47 pubmed publisher
    ..Expression of an investigator-selected set of pain signaling genes (including ASIC3, ATF3, COX2, CX3CL1, NAV1.7, NAV1.8, NAV1...
  11. Wang I, Chung C, Liao F, Chen C, Lee C. Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis. Sci Rep. 2017;7:42304 pubmed publisher
    ..Elicited pain levels were as high in Asic1a-/-, Asic2-/- and Asic3-/- mice as wild-type mice even though only Asic1a-/- mice showed reduced EAE disease ..
  12. Gregory N, Gautam M, Benson C, Sluka K. Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics. Neuroscience. 2018;386:166-174 pubmed publisher
    ..We have previously shown ASIC3 is important in activity-induced hyperalgesia...
  13. Yu G, Liu D, Yuan N, Liu B. Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection?. Immunopharmacol Immunotoxicol. 2018;40:273-277 pubmed publisher
    ..Amongst different subtypes, ASIC3 has received much attention in joint inflammatory conditions including rheumatoid arthritis...
  14. Dušenková S, Ru F, Surdenikova L, Nassenstein C, Hatok J, Dušenka R, et al. The expression profile of acid-sensing ion channel (ASIC) subunits ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 in the esophageal vagal afferent nerve subtypes. Am J Physiol Gastrointest Liver Physiol. 2014;307:G922-30 pubmed publisher
    ..ASIC1, ASIC2, and ASIC3 were expressed in 65-75%, 55-70%, and 70%, respectively, of both nodose and jugular TRPV1-positive neurons...
  15. Reimers C, Lee C, Kalbacher H, Tian Y, Hung C, Schmidt A, et al. Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain. Proc Natl Acad Sci U S A. 2017;114:E3507-E3515 pubmed publisher
    ..conopeptide of only four amino acids from the venom of Conus textile that strongly potentiated currents of ASIC3, which has a specific role in the pain pathway. This peptide, RPRFamide, belongs to the subgroup of cono-RFamides...
  16. Zhou H, Wang X, Wang S, Liu C, Fu Q, Qin G, et al. Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats. Neuroscience. 2019;398:252-262 pubmed publisher
    Our previous study showed that acid-sensing ion channel 3 (ASIC3) in the trigeminal nucleus caudalis (TNC) is involved in the pathogenesis of recurrent migraine...
  17. Shudong W, Lide Z, Baoqiang D, Wenshun Z, Ee H, Na G, et al. Protein and RNA expression of acid-sensing ion channels 2 and 3 in myocardial ischemia rats induced by isoproterenol. J Tradit Chin Med. 2015;35:222-6 pubmed
    ..at the Neiguan (PC 6) acupoint on protein and RNA expression of acid-sensing ion channel 2 (ASIC2) and ASIC3 in myocardial ischemia rats. Fifty male Sprague-Dawley rats were used, weighing (230 ± 50) g...
  18. Wang D, Pan H, Zhu H, Zhu L, He Y, Wang J, et al. Upregulation of nuclear factor??B and acid sensing ion channel 3 in dorsal root ganglion following application of nucleus pulposus onto the nerve root in rats. Mol Med Rep. 2017;16:4309-4314 pubmed publisher
    ..is caused by the nucleus pulposus, the expression and regulation of nuclear factor (NF)??B and acid sensing ion channel 3 (ASIC3) were examined...
  19. Du J, Reznikov L, Welsh M. Expression and activity of acid-sensing ion channels in the mouse anterior pituitary. PLoS ONE. 2014;9:e115310 pubmed publisher
    ..in the pituitary and found mRNA expression for all ASIC isoforms, including ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4...
  20. Wang S, Wu B, Liu C, Qin G, Yan W, Zhou J, et al. Expression of ASIC3 in the Trigeminal Nucleus Caudalis Plays a Role in a Rat Model of Recurrent Migraine. J Mol Neurosci. 2018;66:44-52 pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) is abundant in the trigeminal nervous system and is most sensitive to a slight pH decrease...
  21. Andreev Y, Osmakov D, Koshelev S, Maleeva E, Logashina Y, Palikov V, et al. Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds. Mar Drugs. 2018;16: pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) makes an important contribution to the development and maintenance of inflammatory and acid-induced pain...
  22. Sugimura N, Ikeuchi M, Izumi M, Kawano T, Aso K, Kato T, et al. Repeated intra-articular injections of acidic saline produce long-lasting joint pain and widespread hyperalgesia. Eur J Pain. 2015;19:629-38 pubmed publisher
    ..roles of proton-gated ion channels, rats were injected intra-articularly with selective antagonists for ASIC1a, ASIC3 and TRPV1 on day 5 (before the second injection) or on day 14...
  23. Abboud F, Benson C. ASICs and cardiovascular homeostasis. Neuropharmacology. 2015;94:87-98 pubmed publisher
    ..We identified a role for ASIC2 in the mechano-sensitivity of aortic baroreceptors and of ASIC3 in the pH sensitivity of carotid bodies...
  24. Deval E, Lingueglia E. Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems. Neuropharmacology. 2015;94:49-57 pubmed publisher
    ..Functional ASICs are homo or heterotrimers of different homologous subunits (ASIC1-3). Channels containing ASIC3 or ASIC1 subunits, appear to be important in peripheral nociceptors, where they are subject to intense regulation, ..
  25. Meng Q, Fang P, Hu Z, Ling Y, Liu H. Mechanotransduction of trigeminal ganglion neurons innervating inner walls of rat anterior eye chambers. Am J Physiol Cell Physiol. 2015;309:C1-10 pubmed publisher
    ..Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), acid-sensing ion channel (ASIC) 2 and ASIC3 channel proteins were expressed in FAST DiI-labeled TG neurons...
  26. Callejo G, Castellanos A, Castany M, Gual A, Luna C, Acosta M, et al. Acid-sensing ion channels detect moderate acidifications to induce ocular pain. Pain. 2015;156:483-95 pubmed publisher
    ..Moderate acidic pH (6.6) activated ASIC-like currents in corneal sensory neurons, which were blocked by ASIC1- or ASIC3-specific toxins...
  27. Reiners M, Margreiter M, Oslender Bujotzek A, Rossetti G, Grunder S, Schmidt A. The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain. Mol Pharmacol. 2018;94:1114-1124 pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) is a proton-gated Na+ channel with important roles in pain. ASIC3 quickly desensitizes in less than a second, limiting its capacity to sense sustained acidosis during pain...
  28. Chen W, Lee C, Lin S, Wong C, Sun W, Wood J, et al. Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain. 2014;10:40 pubmed publisher
    ..changes of muscle nociceptors were modality-specific and required the activation of acid-sensing ion channel 3 (ASIC3) or transient receptor potential cation channel V1 (TRPV1)...
  29. Jensen J, Cristofori Armstrong B, Anangi R, Rosengren K, Lau C, Mobli M, et al. Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores. J Med Chem. 2014;57:9195-203 pubmed publisher
    The sea anemone peptide APETx2 is a potent and selective blocker of acid-sensing ion channel 3 (ASIC3)...
  30. Peng Z, Li W, Huang C, Jiang Y, Wang X, Zhu M, et al. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Rep. 2015;13:387-98 pubmed publisher
    ..Here, we report a role for acid-sensing ion channel 3 (ASIC3) in mediating itch evoked by certain pruritogens during tissue acidosis...
  31. Stone A, Copp S, Kim J, Kaufman M. Combined, but not individual, blockade of ASIC3, P2X, and EP4 receptors attenuates the exercise pressor reflex in rats with freely perfused hindlimb muscles. J Appl Physiol (1985). 2015;119:1330-6 pubmed publisher
    ..We then examined the effects of combined blockade of P2X receptors, ASIC3 channels, and EP4 receptors on the exercise pressor reflex using the same doses, intra-arterial route, and time ..
  32. Detweiler N, Vigil K, Resta T, Walker B, Jernigan N. Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. PLoS ONE. 2018;13:e0192724 pubmed publisher
    ..Whole-body plethysmography was used to monitor ventilatory parameters in conscious, unrestrained ASIC1, ASIC2, or ASIC3 knockout (-/-) and wild-type (WT) mice at baseline, during isocapnic hypoxemia and during hypercapnia...
  33. Taguchi T, Katanosaka K, Yasui M, Hayashi K, Yamashita M, Wakatsuki K, et al. Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain. 2015;156:415-27 pubmed publisher
    ..mechanical hyperalgesia was significantly reversed by subcutaneous injection of APETx2, a selective blocker of ASIC3. Single-fiber recordings in vitro revealed facilitated mechanical responses of mechanoresponsive C-fibers both in ..
  34. Cao Q, Xiao Z, Wang X, Weng C, Ding M, Zhu F, et al. Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function. Neurochem Res. 2018;43:1227-1241 pubmed publisher
    ..Particularly, acid sensing ion channel 3 (ASIC3) is the most sensitive to extracellular pH and has the characteristic ability to generate a ..
  35. Jalalvand E, Robertson B, Tostivint H, Wallén P, Grillner S. The Spinal Cord Has an Intrinsic System for the Control of pH. Curr Biol. 2016;26:1346-51 pubmed publisher
    ..The acidic response is due to an activation of ASIC3 [6]. The discharge pattern of the CSF-c neurons is U-shaped with a minimum frequency around pH 7...
  36. Ru F, Banovcin P, Kollarik M. Acid sensitivity of the spinal dorsal root ganglia C-fiber nociceptors innervating the guinea pig esophagus. Neurogastroenterol Motil. 2015;27:865-74 pubmed publisher
    ..DRG C-fiber neurons (TRPV1-positive) expressed mRNA for acid sensing ion channels (ASIC1a, ASIC1b, ASIC2b, and/or ASIC3), two-pore-domain (K2P) potassium channel TASK1, and the proton-sensing G-protein coupled receptor OGR1...
  37. Kalina R, Gladkikh I, Dmitrenok P, Chernikov O, Koshelev S, Kvetkina A, et al. New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels. Peptides. 2018;104:41-49 pubmed publisher
    ..The percent of identity of Hcr 1b-2, -3, and -4 with well-known ASIC3 inhibitors Hcr 1b-1 from H. crispa and APETx2 from Anthopleura elegantissima is 95-78% and 46-49%, respectively...
  38. Holzer P. Acid-sensing ion channels in gastrointestinal function. Neuropharmacology. 2015;94:72-9 pubmed publisher
    ..In the gut, ASICs (ASIC1, ASIC2, ASIC3) are primarily expressed by the peripheral axons of vagal and spinal afferent neurons and are responsible for ..
  39. Heo M, Kim J, Hwang I, Ha E, Park K. Analgesic effect of quetiapine in a mouse model of cancer-induced bone pain. Korean J Intern Med. 2017;32:1069-1074 pubmed publisher
    ..of transient receptor potential vanilloid 1 (TRPV1), TRPV4, acid-sensing ion channel 1 (ASIC1), ASIC2, and ASIC3 expression...
  40. Izurieta Munoz H, Gonzales E, Sumien N. Effects of creatine supplementation on nociception in young male and female mice. Pharmacol Rep. 2018;70:316-321 pubmed publisher
    ..To determine whether ASICs mediate the action of creatine, GMQ, an ASIC3 agonist, was injected in one paw and pain response was quantified...
  41. Jalalvand E, Robertson B, Tostivint H, Low P, Wallén P, Grillner S. Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus. J Neurosci. 2018;38:7713-7724 pubmed publisher
    ..In the same neuron, acidic and alkaline responses are mediated through ASIC3-like and PKD2L1 channels, respectively...
  42. Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, et al. The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nat Commun. 2018;9:1354 pubmed publisher
    Two subclasses of acid-sensing ion channels (ASIC3) and of ATP-sensitive P2X receptors (P2X3Rs) show a partially overlapping expression in sensory neurons...
  43. Kim J, Williams F, Dreger D, Plassais J, Davis B, Parker H, et al. Genetic selection of athletic success in sport-hunting dogs. Proc Natl Acad Sci U S A. 2018;115:E7212-E7221 pubmed publisher
    ..under strong selection in sport-hunting breeds, including ADRB1, TRPM3, RYR3, UTRN, ASIC3, and ROBO1 We also identified an allele of TRPM3 that was significantly associated with ..
  44. Zuo Z, Smith R, Chen Z, Agharkar A, Snell H, Huang R, et al. Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3. Nat Commun. 2018;9:2082 pubmed publisher
    ..The channel-blocking activity is most apparent in ASIC3, as removing Ca2+ results in channel opening, with the site's location remaining unresolved...
  45. Lin J, Chiang Y, Chen C. Research strategies for pain in lumbar radiculopathy focusing on acid-sensing ion channels and their toxins. Curr Top Med Chem. 2015;15:617-30 pubmed
    ..b>ASIC3 is involved in inflammatory pain and ischemic pain, and, likely, mechanical pain...
  46. Ma N, Feng H, Meng X, Li D, Yang D, Wu C, et al. Overexpression of tomato SlNAC1 transcription factor alters fruit pigmentation and softening. BMC Plant Biol. 2014;14:351 pubmed publisher
    ..Tissue-specific analysis by quantitative real-time PCR showed that SlNAC1 was highly accumulated in immature green fruits; the expression of SlNAC1 increased with fruit ripening till to ..
  47. Tikhonova T, Nagaeva E, Barygin O, Potapieva N, Bolshakov K, Tikhonov D. Monoamine NMDA receptor channel blockers inhibit and potentiate native and recombinant proton-gated ion channels. Neuropharmacology. 2015;89:1-10 pubmed publisher
    ..The compounds caused a complex effect on ASIC3. 9-aminoacridine and IEM-1921 potentiated the steady-state response of ASIC3 and inhibited the peak component...
  48. Yu X, Hu Z, Ni M, Fang P, Zhang P, Shu Q, et al. Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia. Glia. 2015;63:483-96 pubmed publisher
    ..PCR (qPCR), western blotting, and immunofluorescence experiments, we demonstrated that ASIC1, ASIC2a, and ASIC3 were existed in cultured and in situ rat microglia...
  49. Martínez Rojas V, Barragán Iglesias P, Rocha González H, Murbartián J, Granados Soto V. Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia. Pharmacol Rep. 2014;66:964-71 pubmed publisher
    ..study we determined the role of transient receptor potential V1 channel (TRPV1) and acid-sensing ion channel 3 (ASIC3) in chronic nociception. 1% formalin was used to produce long-lasting secondary allodynia and hyperalgesia in rats...
  50. Lin S, Steinhoff M, Ikoma A, Chang Y, Cheng Y, Chandra Kopparaju R, et al. Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis. J Invest Dermatol. 2017;137:170-178 pubmed publisher
    ..Results indicate that TRPV1, but neither ASIC3 nor TRPA1, is involved in the acidic citrate-induced scratching response...
  51. Mukhopadhyay M, Singh A, Sachchidanand S, Bera A. Quercetin inhibits acid-sensing ion channels through a putative binding site in the central vestibular region. Neuroscience. 2017;348:264-272 pubmed publisher
    ..flavonoid, which is known for its neuroprotective effect, reversibly inhibits homomeric rat ASIC1a, ASIC2a and ASIC3 with an IC50 of about 2µM...
  52. Schwartz V, Friedrich K, Polleichtner G, Gründer S. Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression. Sci Rep. 2015;5:18242 pubmed publisher
    ..Six different ASICs have been identified (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4) that are activated by a drop in extracellular pH, either as homo- or heteromers...
  53. Sun W, Chen C. Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain. J Dent Res. 2016;95:135-42 pubmed publisher
    ..Acid-sensing ion channel 3 (ASIC3) and transient receptor potential/vanilloid receptor subtype 1 (TRPV1) are 2 major acid sensors involved in the ..
  54. Schmidt A, Alsop R, Rimal R, Lenzig P, Joussen S, Gervasi N, et al. Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations. Biophys J. 2018;114:1321-1335 pubmed publisher
    ..Here, we show that DEG/ENaCs ASIC1a, ASIC3, ENaC, and the purinergic receptor P2X2 are modulated by a large number of different, structurally unrelated ..
  55. Gui Q, Xu C, Li D, Zhuang L, Xia S, Yu S. Urinary N telopeptide levels in predicting the anti-nociceptive responses of zoledronic acid and paclitaxel in a rat model of bone metastases. Mol Med Rep. 2015;12:4243-4249 pubmed publisher
    ..Furthermore, the mRNA and protein expression levels of c?fos in the spinal cord and acid?sensing ion channel 3 (ASIC3) in the dorsal root ganglion (DRG) were analyzed...
  56. Ying Wang -, Zhao W, Li D, Xu Y, Li M, Chen J, et al. The Beneficial Effects of Electroacupuncture at PC6 Acupoints (Neiguan) on Myocardial Ischemia in ASIC3 -/- mice. J Acupunct Meridian Stud. 2018;11:88-96 pubmed publisher
    ..Mice in the control group were injected with saline (20 mg/kg, 24 hours interval), and the other ASIC3 -/- mice were injected subcutaneously twice with isoproterenol (ISO) (20 mg/kg, 24 hours interval)...
  57. Ross J, Queme L, Cohen E, Green K, Lu P, Shank A, et al. Muscle IL1? Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization. J Neurosci. 2016;36:6857-71 pubmed publisher
    ..on acid-sensing ion channels (ASICs) because treatment of sensory afferents in vitro with IL1?-upregulated ASIC3 in single cells, and nerve-specific knock-down of ASIC3 recapitulated the results of inhibiting the enhanced IL1?/..
  58. Osmakov D, Koshelev S, Belozerova O, Kublitski V, Andreev Y, Grishin E, et al. [The Biological Activity of the Sevanol and Its Analogues]. Bioorg Khim. 2015;41:606-11 pubmed
    ..was isolated, it's structure was elucidated and was shown that it effectively inhibits the acid-sensing channel ASIC3 and also exhibits a pronounced analgesic and anti-inflammatory effect...
  59. Corrow K, Girard B, Vizzard M. Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis. Am J Physiol Renal Physiol. 2010;298:F1130-9 pubmed publisher
    The expression of acid-sensing ion channel (ASIC) isoforms, ASIC1, ASIC2a, and ASIC3, was examined in the urinary bladder after cyclophosphamide (CYP)-induced cystitis of varying duration (4 h, 48 h, and chronic)...
  60. Gregory N, Brito R, Fusaro M, Sluka K. ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia. Mol Neurobiol. 2016;53:1020-30 pubmed publisher
    ..We hypothesized that proton accumulation during muscle fatigue activates acid-sensing ion channel 3 (ASIC3) on muscle nociceptors to produce hyperalgesia...
  61. Jalalvand E, Robertson B, Wallén P, Grillner S. Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3. Nat Commun. 2016;7:10002 pubmed publisher
    ..These effects are most likely mediated by ASIC3-channels, since APETx2, a specific antagonist of ASIC3, blocks them both...
  62. Xin J, Su Y, Yang Z, He W, Shi H, Wang X, et al. Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia. Front Med. 2016;10:465-472 pubmed publisher
    ..This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia...
  63. Hanaka M, Iba K, Dohke T, Kanaya K, Okazaki S, Yamashita T. Antagonists to TRPV1, ASICs and P2X have a potential role to prevent the triggering of regional bone metabolic disorder and pain-like behavior in tail-suspended mice. Bone. 2018;110:284-294 pubmed publisher
    ..The effects of the TRPV1, ASIC3, P2X2/3 antagonists on pain-like behaviors as assessed by the von Frey test, paw flick test and spontaneous pain ..
  64. Vralsted V, Price M, Du J, Schnizler M, Wunsch A, Ziemann A, et al. Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes Brain Behav. 2011;10:444-50 pubmed publisher
    ..effects of altering the subunit composition of brain ASICs on behavior, we developed transgenic mice expressing ASIC3 via the pan-neuronal synapsin I promoter...
  65. Sluka K, Gregory N. The dichotomized role for acid sensing ion channels in musculoskeletal pain and inflammation. Neuropharmacology. 2015;94:58-63 pubmed publisher
    ..Of the different types of ASICs, ASIC3 and ASIC1 have been implicated in transmission of nociceptive information from the musculoskeletal system...
  66. Agharkar A, Gonzales E. 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J Pharmacol Sci. 2017;133:184-186 pubmed publisher
    ..The ASIC3 subtype is found primarily in the periphery where the channel mediates pain signals caused by ischemia and ..
  67. Yuan L, Bo Y, Qin Z, Ran H, Li W, Li Y, et al. Expression of Acid-Sensing Ion Channels in Renal Tubular Epithelial Cells and Their Role in Patients with Henoch-Schönlein Purpura Nephritis. Med Sci Monit. 2017;23:1916-1922 pubmed
    ..RESULTS The results showed that ASIC1, ASIC2, and ASIC3 proteins were obviously expressed in renal tubular cells from HSPN patients...
  68. Vanhaitsma T, Light A, Light K, Hughen R, Yenchik S, White A. Fatigue sensation and gene expression in trained cyclists following a 40 km time trial in the heat. Eur J Appl Physiol. 2016;116:541-52 pubmed publisher
    ..30). Both trials resulted in significant post-exercise decreases in metabolite detecting receptors ASIC3, P2X4, TRPV1, and TRPV4; increases in adrenergic receptors α2a, α2c, and β1; decreases in adrenergic β..
  69. Liang J, Huang L, Chen X, Pan S, Lu Z, Xiao Z. Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats. Int J Clin Exp Pathol. 2015;8:14507-13 pubmed
    ..The expression of ASIC1a, ASIC3 and sodium-hydrogen exchanger (NHE) in each group was detected...
  70. Kweon H, Cho J, Jang I, Suh B. ASIC2a-dependent increase of ASIC3 surface expression enhances the sustained component of the currents. BMB Rep. 2016;49:542-547 pubmed
    ..In this study, we investigated the differential subcellular localization of ASIC2a and ASIC3 in heterologous expression systems...
  71. Liu X, Chen J, Li H, Li H, Yin S. [Expression of Type 3 Acid Sensitive Ion Channels in Bladder of OAB Rat Model]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2016;47:174-9 pubmed
    To investigate the expression of type 3 acid-sensing ion channels (ASIC3) in bladder tissue of over active bladder (OAB) rat model. Sixty adult female rats were randomly divided into control group (intraperitoneal injection of 0...
  72. Lin S, Cheng Y, Banks R, Min M, Bewick G, Chen C. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors. Nat Commun. 2016;7:11460 pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed...
  73. Gao M, Long H, Ma W, Liao L, Yang X, Zhou Y, et al. The role of periodontal ASIC3 in orofacial pain induced by experimental tooth movement in rats. Eur J Orthod. 2016;38:577-583 pubmed
    This study aimed to clarify the roles of Acid-sensing ion channel 3 (ASIC3) in orofacial pain following experimental tooth movement...
  74. Osmakov D, Koshelev S, Andreev Y, Dyachenko I, Bondarenko D, Murashev A, et al. Conversed mutagenesis of an inactive peptide to ASIC3 inhibitor for active sites determination. Toxicon. 2016;116:11-6 pubmed publisher
    Peptide Ugr9-1 from the venom of sea anemone Urticina grebelnyi selectively inhibits the ASIC3 channel and significantly reverses inflammatory and acid-induced pain in vivo. A close homolog peptide Ugr 9-2 does not have these features...
  75. Wu L, Oshima T, Shan J, Sei H, Tomita T, Ohda Y, et al. PAR-2 activation enhances weak acid-induced ATP release through TRPV1 and ASIC sensitization in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2015;309:G695-702 pubmed publisher
    ..TRPV1 and ASIC3 small interfering RNA (siRNA) transfection also decreased weak acid-induced ATP release...
  76. Fu H, Fang P, Zhou H, Zhou J, Yu X, Ni M, et al. Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain. Clin Exp Pharmacol Physiol. 2016;43:193-202 pubmed publisher
    ..Accumulating evidence suggests that acid-sensing ion channels (ASICs), especially ASIC3, can profoundly affect the physiological properties of nociception in peripheral sensory neurons...
  77. Kobayashi Y, Sekiguchi M, Konno S. Effect of an Acid-sensing Ion Channels Inhibitor on Pain-related Behavior by Nucleus Pulposus Applied on the Nerve Root in Rats. Spine (Phila Pa 1976). 2017;42:E633-E641 pubmed publisher
    Controlled, interventional animal study. To examine the effect of an inhibitor of acid-sensing ion channel 3 (ASIC3) on pain-related behavior induced by application of the nucleus pulposus (NP) onto the dorsal root ganglion (DRG) in rats...
  78. Hiasa M, Okui T, Allette Y, Ripsch M, Sun Wada G, Wakabayashi H, et al. Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3. Cancer Res. 2017;77:1283-1295 pubmed publisher
    ..CGRP+ sensory nerves also expressed increased levels of the acid-sensing nociceptor ASIC3. Notably, a single injection of the selective ASIC3 antagonist APETx2 dramatically reduced MMBP in the model...
  79. Xu X, Cao Y, Ding T, Fu K, Li Y, Xie Q. Role of TRPV1 and ASIC3 channels in experimental occlusal interference-induced hyperalgesia in rat masseter muscle. Eur J Pain. 2016;20:552-63 pubmed publisher
    ..Transient receptor potential vanilloid-1 (TRPV1) and acid-sensing ion channel-3 (ASIC3) mediate muscle hyperalgesia under various pathologic conditions...
  80. Meng C, Yang D, Ma X, Zhao W, Liang X, Ma N, et al. Suppression of tomato SlNAC1 transcription factor delays fruit ripening. J Plant Physiol. 2016;193:88-96 pubmed publisher
    ..In this study, SlNAC1 was cloned...
  81. Dubinnyi M, Osmakov D, Koshelev S, Kozlov S, Andreev Y, Zakaryan N, et al. Lignan from thyme possesses inhibitory effect on ASIC3 channel current. J Biol Chem. 2012;287:32993-3000 pubmed
    ..natural molecule that has a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in Xenopus laevis oocytes...
  82. Xie J, Price M, Berger A, Welsh M. DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels. J Neurophysiol. 2002;87:2835-43 pubmed
    ..Large DRG neurons express the dorsal root acid sensing ion channel (DRASIC), suggesting that DRASIC might contribute to H+-gated DRG currents...
  83. Birdsong W, Fierro L, Williams F, Spelta V, Naves L, Knowles M, et al. Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron. 2010;68:739-49 pubmed publisher
    ..ATP), works together with acid by increasing the pH sensitivity of acid-sensing ion channel number 3 (ASIC3), the molecule used by sensory neurons to detect lactic acidosis...
  84. Omar S, Clarke R, Abdullah H, Brady C, Corry J, Winter H, et al. Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells. PLoS ONE. 2017;12:e0171681 pubmed publisher
    ..receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3)...
  85. Yuan F, Chen F, Lu W, Li X. Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis. Mol Biol Rep. 2010;37:3233-8 pubmed publisher
    Acid-sensing ion channels 3 (ASIC3) is the most sensitive to such a pH change, predominantly distributed in the sensory peripheral nervous system, and strongly correlated with pain...
  86. Osmakov D, Kozlov S, Andreev Y, Koshelev S, Sanamyan N, Sanamyan K, et al. Sea anemone peptide with uncommon ?-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity. J Biol Chem. 2013;288:23116-27 pubmed publisher
    ..name Ugr 9-1), produced a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in Xenopus laevis oocytes. It completely blocked the transient component (IC50 10 ± 0...
  87. Catarsi S, Babinski K, Seguela P. Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF. Neuropharmacology. 2001;41:592-600 pubmed
    ..These modulatory effects were not observed with the corresponding homomeric human ASIC2A or ASIC3 receptor subtypes...
  88. Ko Y, Hsu L, Wu S, Teng M, Chang H, Chen C, et al. Genetic variation in the ASIC3 gene influences blood pressure levels in Taiwanese. J Hypertens. 2008;26:2154-60 pubmed publisher
    The acid-sensing ion channel 3 (ASIC3) is a ligand-gated cation channel activated by extracellular protons, and is associated with an exercise-induced pressor reflex and possibly autonomic imbalance...
  89. Cao Q, Wang W, Gu J, Jiang G, Wang K, Xu Z, et al. Elevated Expression of Acid-Sensing Ion Channel 3 Inhibits Epilepsy via Activation of Interneurons. Mol Neurobiol. 2016;53:485-498 pubmed publisher
    ..In particular, acid-sensing ion channel 3 (ASIC3) is expressed in the central nervous system and is most sensitive to extracellular pH...
  90. Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E. The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. J Biol Chem. 2002;277:16655-61 pubmed
    ..The ASIC3 subunit is mainly expressed in dorsal root ganglion neurons...
  91. Leonard A, Yermolaieva O, Hruska Hageman A, Askwith C, Price M, Wemmie J, et al. cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A. 2003;100:2029-34 pubmed
    ..Thus, the ASIC1 C terminus contains two sites that influence its binding to PICK1. Regulation of this interaction by phosphorylation provides a mechanism to control the cellular localization of ASIC1. ..
  92. Hruska Hageman A, Benson C, Leonard A, Price M, Welsh M. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004;279:46962-8 pubmed
    The acid-sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral nervous system...