ASH1L

Summary

Gene Symbol: ASH1L
Description: ash1 (absent, small, or homeotic)-like (Drosophila)
Alias: ASH1, ASH1L1, KMT2H, ASH1-like protein, absent small and homeotic disks protein 1 homolog, histone-lysine N-methyltransferase ASH1L, lysine N-methyltransferase 2H
Species: human

Top Publications

  1. ncbi Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
  2. ncbi Feed-forward regulation of a cell fate determinant by an RNA-binding protein generates asymmetry in yeast
    Joshua J Wolf
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 185:513-22. 2010
  3. ncbi Expression pattern of a butterfly achaete-scute homolog reveals the homology of butterfly wing scales and insect sensory bristles
    R Galant
    Howard Hughes Medical Institute, Madison, Wisconsin, USA
    Curr Biol 8:807-13. 1998
  4. ncbi An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast
    R M Long
    Medical College of Wisconsin, Department of Microbiology and Molecular Genetics, Milwaukee, Wisconsin 53226, USA
    J Cell Biol 153:307-18. 2001
  5. ncbi Regulation of H3K27me3 and H3K4me3 during early porcine embryonic development
    Yu Gao
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Copenhagen, Denmark
    Mol Reprod Dev 77:540-9. 2010
  6. ncbi A novel mRNA affinity purification technique for the identification of interacting proteins and transcripts in ribonucleoprotein complexes
    Boris Slobodin
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    RNA 16:2277-90. 2010
  7. ncbi The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED MICROSPORES (AMS)
    Tage Thorstensen
    Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindern, 0316 Oslo, Norway
    Plant Mol Biol 66:47-59. 2008
  8. ncbi She3p possesses a novel activity required for ASH1 mRNA localization in Saccharomyces cerevisiae
    Sharon M Landers
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Eukaryot Cell 8:1072-83. 2009
  9. ncbi ASH1 mRNA localization in three acts
    D L Beach
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 12:2567-77. 2001
  10. ncbi Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p
    Nicolas Paquin
    Departement de Biochimie, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Mol Cell 26:795-809. 2007

Research Grants

  1. Mechanism of mRNA transport by Myo4p
    Peter Takizawa; Fiscal Year: 2009
  2. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2005
  3. Biochemistry and Structure of RNA-Protein Complexes
    James Williamson; Fiscal Year: 2006
  4. An E3 Ubiquitin Ligase Complex That Regulates C. elegans Developmental Timing
    Adam Antebi; Fiscal Year: 2009
  5. An E3 Ubiquitin Ligase Complex That Regulates C. elegans Developmental Timing
    Adam Antebi; Fiscal Year: 2007
  6. The switch between epigenetically silenced and active chromatin states
    Vincenzo Pirrotta; Fiscal Year: 2010
  7. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert H Singer; Fiscal Year: 2010
  8. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2007
  9. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2006
  10. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
    ..that critical for the active state of PcG target genes are the histone methyltransferases Trithorax (TRX) and ASH1. Here we analyze the repertoire of alternative states in which PcG target genes are found in different Drosophila ..
  2. ncbi Feed-forward regulation of a cell fate determinant by an RNA-binding protein generates asymmetry in yeast
    Joshua J Wolf
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 185:513-22. 2010
    ..Khd1 represses transcription of FLO11 indirectly through its regulation of ASH1 mRNA. Khd1 also represses FLO11 through a post-transcriptional mechanism independent of ASH1...
  3. ncbi Expression pattern of a butterfly achaete-scute homolog reveals the homology of butterfly wing scales and insect sensory bristles
    R Galant
    Howard Hughes Medical Institute, Madison, Wisconsin, USA
    Curr Biol 8:807-13. 1998
    ....
  4. ncbi An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast
    R M Long
    Medical College of Wisconsin, Department of Microbiology and Molecular Genetics, Milwaukee, Wisconsin 53226, USA
    J Cell Biol 153:307-18. 2001
    The localization of ASH1 mRNA to the distal tip of budding yeast cells is essential for the proper regulation of mating type switching in Saccharomyces cerevisiae...
  5. ncbi Regulation of H3K27me3 and H3K4me3 during early porcine embryonic development
    Yu Gao
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Copenhagen, Denmark
    Mol Reprod Dev 77:540-9. 2010
    ..EZH2), EZH2 co-factors (EED and SUZ12) and demethylases (JMJD3 and UTX), as well as H3K4me3's methylases (ASH1L and MLL1) and demethylase (RBP2) in porcine pre-implantation embryos...
  6. ncbi A novel mRNA affinity purification technique for the identification of interacting proteins and transcripts in ribonucleoprotein complexes
    Boris Slobodin
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    RNA 16:2277-90. 2010
    ..g., ASH1-She2; β-Actin-IMP1). By isolating tagged OXA1 mRNA using RaPID, we could identify a yeast COPI subunit (i.e...
  7. ncbi The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED MICROSPORES (AMS)
    Tage Thorstensen
    Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindern, 0316 Oslo, Norway
    Plant Mol Biol 66:47-59. 2008
    ..analyzed the Arabidopsis trxG protein ASHR3 which has a SET domain and pre- and post-SET domains similar to that of Ash1 in Drosophila...
  8. ncbi She3p possesses a novel activity required for ASH1 mRNA localization in Saccharomyces cerevisiae
    Sharon M Landers
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Eukaryot Cell 8:1072-83. 2009
    ..One mechanism for sorting proteins is through RNA localization. In Saccharomyces cerevisiae, ASH1 mRNA localizes to the distal tip of the bud, resulting in the asymmetric sorting of the transcriptional repressor ..
  9. ncbi ASH1 mRNA localization in three acts
    D L Beach
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 12:2567-77. 2001
    ..In budding yeast, ASH1 mRNA is translocated via actin and myosin to the tip of growing cells...
  10. ncbi Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p
    Nicolas Paquin
    Departement de Biochimie, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Mol Cell 26:795-809. 2007
    In S. cerevisiae, the ASH1 mRNA is localized at the bud tip of late-anaphase cells, resulting in the exclusive sorting of Ash1p to the daughter cell nucleus...
  11. ncbi Trithorax-group protein ASH1 methylates histone H3 lysine 36
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, Japan
    Gene 397:161-8. 2007
    Drosophila discs absent, small, or homeotic-1 (ASH1) is a member of trithorax-group proteins that play essential roles in epigenetic regulation of Hox genes...
  12. ncbi The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast
    Kenji Irie
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    EMBO J 21:1158-67. 2002
    RNA localization is a widespread mechanism for achieving localized protein synthesis. In Saccharomyces cerevisiae, Ash1 is a specific repressor of transcription that localizes asymmetrically to the daughter cell nucleus through the ..
  13. ncbi The protein kinase Pho85 is required for asymmetric accumulation of the Ash1 protein in Saccharomyces cerevisiae
    H J McBride
    Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Mol Microbiol 42:345-53. 2001
    The Ash1 protein is a daughter cell-specific repressor of HO gene transcription in Saccharomyces cerevisiae...
  14. ncbi Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8610, Japan
    Biochem Biophys Res Commun 365:589-94. 2008
    We have previously isolated a mammalian homologue of Drosophila discsabsent, small, orhomeotic-1 (ash1) from the murine thymus, and recently shown that its SET domain methylates histone H3 lysine 36 (K36)...
  15. ncbi Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer
    Hirotaka Osada
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Res 68:1647-55. 2008
    The proneural basic-helix-loop-helix protein achaete-scute homologue 1 (ASH1) is expressed in a very limited spectrum of normal and cancerous cells in a lineage-specific manner, including normal pulmonary neuroendocrine cells and lung ..
  16. ncbi Nuclear shuttling of She2p couples ASH1 mRNA localization to its translational repression by recruiting Loc1p and Puf6p
    Zhifa Shen
    Departement de Biochimie, Universite de Montreal, Canada
    Mol Biol Cell 20:2265-75. 2009
    ..In yeast, the nucleocytoplasmic shuttling protein She2 binds the ASH1 mRNA and targets it for localization at the bud tip by recruiting the She3p-Myo4p complex...
  17. ncbi Local regulation of mRNA translation: new insights from the bud
    Nicolas Paquin
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, H3C 3J7 Canada
    Trends Cell Biol 18:105-11. 2008
    ..To avoid any ectopic expression, translation of the bud-localized ASH1 mRNA is repressed by the translational repressors Puf6p and Khd1p during its transport...
  18. ncbi Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions
    Britta Skawran
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Mod Pathol 21:505-16. 2008
    ..down the number of dysregulated genes to 18, with 7 genes localised on 1q22 (SCAMP3, IQGAP3, PYGO2, GPATC4, ASH1L, APOA1BP, and CCT3). In hepatocellular adenoma 26 genes in bands 11p15, 11q12, and 12p13 were upregulated...
  19. ncbi Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes
    Gregory D Gregory
    Children s Hospital of Philadelphia, Division of Hematology, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:8466-79. 2007
    ..To identify the enzymes responsible for placing these modifications, we examined ASH1L, the mammalian homolog of the Drosophila melanogaster Trithorax group (TrxG) protein Ash1...
  20. ncbi Multigene real-time PCR detection of circulating tumor cells in peripheral blood of lung cancer patients
    Dawn C Hayes
    GSK Biologicals Seattle, 1900 9th Avenue, Suite 1100, Seattle, WA 98101 USA
    Anticancer Res 26:1567-75. 2006
    CLCA2, HMGB3, L587S and ASH1 were identified in lung cancer tissues using genetic subtraction, microarray and quantitative PCR, and found to be specific and complementary for detection of non-small cell lung carcinoma (NSCLC) and small ..
  21. ncbi The scaleless wings mutant in Bombyx mori is associated with a lack of scale precursor cell differentiation followed by excessive apoptosis
    Qing Xiang Zhou
    Biotechnology Research Institute, National Key Facility for Crop Gene Resources and Genetic Improvement, Chinese Academy of Agricultural Sciences, 12 Zhongguancun South Street, Beijing, 100081, People s Republic of China
    Dev Genes Evol 216:721-6. 2006
    ..In addition, we have studied Bm-ASH1, an achaete-scute homolog in B...
  22. ncbi Coordination of endoplasmic reticulum and mRNA localization to the yeast bud
    Maria Schmid
    Department of Chemistry and Biochemistry, Gene Center, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    Curr Biol 16:1538-43. 2006
    ..These proteins mediate the localization of 23 mRNAs including ASH1 mRNA and mRNAs encoding membrane proteins...
  23. ncbi Directional mRNA transport in eukaryotes: lessons from yeast
    M Muller
    Gene Center of the Ludwig Maximilians, University Munich and GSF, Institute of Molecular Immunology, Feodor Lynen Strasse 25, 81377, Munich, Germany
    Cell Mol Life Sci 64:171-80. 2007
    ..provides a more detailed description of the most comprehensively studied mRNA translocation complex to date: the ASH1 messenger ribonucleoprotein particle (mRNP) from Saccharomyces cerevisiae...
  24. ncbi The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells
    Julian Vasilescu
    Ottawa Institute of Systems Biology, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    J Proteome Res 6:298-305. 2007
    ..The Proteomic Reactor is a novel technology that facilitates the analysis of affinity-purified proteins and has the potential to aid future biological studies...
  25. ncbi mRNAs encoding polarity and exocytosis factors are cotransported with the cortical endoplasmic reticulum to the incipient bud in Saccharomyces cerevisiae
    Stella Aronov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 27:3441-55. 2007
    ..Asymmetric mRNA localization depends upon factors that facilitate ASH1 mRNA localization (e.g...
  26. ncbi Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions
    Sergi Beltran
    Departament de Genetica, Universitat de Barcelona, Diagonal 645, Barcelona, Spain
    Genome Biol 8:R67. 2007
    The trithorax group (trxG) genes absent, small or homeotic discs 1 (ash1) and 2 (ash2) were isolated in a screen for mutants with abnormal imaginal discs...
  27. ncbi mRNA trafficking in fungi
    Kathi Zarnack
    Department for Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, 35043, Marburg, Germany
    Mol Genet Genomics 278:347-59. 2007
    ..The best-understood example is transport of ASH1 mRNA to the distal pole of the incipient daughter cell...
  28. ncbi Myo4p is a monomeric myosin with motility uniquely adapted to transport mRNA
    Brian D Dunn
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 178:1193-206. 2007
    ..that the unique motility of Myo4p is not due to its motor domain and that the motor domain of Myo2p can transport ASH1 mRNA in vivo...
  29. ncbi Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation
    Yingfeng Deng
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 22:1037-50. 2008
    ..In the yeast Saccharomyces cerevisae, silencing of ASH1 mRNA before it is localized to the bud cortex in late anaphase is critical for asymmetric segregation of Ash1p to ..
  30. ncbi Classifying transcription factor targets and discovering relevant biological features
    Dustin T Holloway
    Molecular Biology Cell Biology and Biochemistry Department, Boston University, 5 Cummington Street, Boston, MA, USA
    Biol Direct 3:22. 2008
    ..The classifiers combine 8 genomic datasets covering a broad range of measurements including sequence conservation, sequence overrepresentation, gene expression, and DNA structural properties...
  31. ncbi The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis
    Paul E Grini
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 4:e7817. 2009
    ..The Arabidopsis ASH1 HOMOLOG 2 (ASHH2) protein (also called SDG8, EFS and CCR1) has been suggested to methylate H3K4 and/or H3K36 and is ..
  32. ncbi Phylotypic expression of the bHLH genes Neurogenin2, Neurod, and Mash1 in the mouse embryonic forebrain
    Joana Osorio
    CNRS, Institute of Neurobiology A Fessard, Development, Evolution, Plasticity of the Nervous System, Research Unit 2197, 91198 Gif sur Yvette, France
    J Comp Neurol 518:851-71. 2010
    ..Neurogenins/NeuroD on the one hand and Ascl1/ash1 on the other hand exhibit essentially mutually exclusive spatial patterns, probably reflecting different positional ..
  33. ncbi Multiple Myo4 motors enhance ASH1 mRNA transport in Saccharomyces cerevisiae
    Sunglan Chung
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 189:755-67. 2010
    In Saccharomyces cerevisiae, ASH1 mRNA is transported to the bud tip by the class V myosin Myo4...
  34. ncbi Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast
    Naoko Mauchi
    Department of Molecular Cell Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai, Tsukuba, Japan
    Cell Struct Funct 35:95-105. 2010
    ..Khd1p associates with hundreds of potential mRNA targets including a bud-localized ASH1 mRNA and mRNAs encoding membrane-associated proteins such as Mid2p and Mtl1p...
  35. ncbi Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism
    Sojin An
    Structural Biology Laboratory of Epigenetics, Department of Biological Sciences, Graduate school of Nanoscience and Technology World Class University, KI for the BioCentury, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong Gu, Daejeon 305 701
    J Biol Chem 286:8369-74. 2011
    ..Here, we present the crystal structure of the human ASH1L catalytic domain, showing its substrate binding pocket blocked by a loop from the post-SET domain...
  36. ncbi Imaging real-time gene expression in living yeast
    Daniel Zenklusen
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    CSH Protoc 2007:pdb.prot4870. 2007
    INTRODUCTIONThis protocol describes the application of the MS2 system to the yeast Saccharomyces cerevisiae. ASH1 mRNA tagged with six MS2 repeats (6MBSs) is used to follow the localization of the ASH1 mRNA particles to the bud tip of a ..
  37. ncbi miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer
    Eri Nishikawa
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 71:6165-73. 2011
    ..The transcription factor ASH1/ASCL1 is a master regulator of pulmonary NE cell development that is involved in the pathogenesis of lung cancers ..
  38. ncbi Daughter-specific transcription factors regulate cell size control in budding yeast
    Stefano Di Talia
    The Rockefeller University, New York, New York, USA
    PLoS Biol 7:e1000221. 2009
    ..smaller daughter cell, which transcribe different genes due to the daughter-specific transcription factors Ace2 and Ash1. Cell size control at the Start checkpoint has long been considered to be a main regulator of the length of the G1 ..
  39. ncbi Neurogenesis in an annelid: characterization of brain neural precursors in the polychaete Capitella sp. I
    Néva P Meyer
    Kewalo Marine Laboratory, Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI 96813, USA
    Dev Biol 335:237-52. 2009
    ..Prior to and during this process, an achaete-scute complex homolog, CapI-ash1, is expressed in clusters of surface cells in the anterior ectoderm, consistent with a proneural function for CapI-..
  40. ncbi Essential features of the class V myosin from budding yeast for ASH1 mRNA transport
    Carol S Bookwalter
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Mol Biol Cell 20:3414-21. 2009
    ..Here, we determine the features of the Myo4p motor that are necessary for correct localization of ASH1 mRNA to the daughter cell, a process that also requires the adapter protein She3p and the dimeric mRNA-binding ..
  41. ncbi Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
    Svetlana Petruk
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 135:2383-90. 2008
    ..Among several trxG and PcG proteins, only Ash1 and Asx require Trithorax in order to bind to their target genes...
  42. ncbi Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA
    Tung Gia Du
    Gene Center, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, D 81377 Munich, Germany
    EMBO Rep 9:781-7. 2008
    ..Here, we show that a specific transcript, known as ASH1 mRNA, and She2 localize specifically to the nucleolus when their nuclear export is blocked...
  43. ncbi Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila
    Enrique Blanco
    Departament de Genètica and Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Barcelona, Catalonia, Spain
    Genome Biol 9:R134. 2008
    ..They bind to specific regions of DNA and direct the post-translational modifications of histones, playing a role in the dynamics of chromatin structure...
  44. ncbi Nonsense-mediated decay of ash1 nonsense transcripts in Saccharomyces cerevisiae
    Wei Zheng
    Laboratories of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 180:1391-405. 2008
    ..In Saccharomyces cerevisiae, wild-type ASH1 mRNA is one of several dozen transcripts that are exported from the mother-cell nucleus during mitotic anaphase, ..
  45. ncbi Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA
    PLoS Genet 4:e1000217. 2008
    ..or function might be regulated by the methylation of histone H3 lysine 4 by the trithorax group proteins ASH1 and TRX...
  46. ncbi Systematic identification of yeast cell cycle transcription factors using multiple data sources
    Wei Sheng Wu
    Department of Evolution and Ecology, University of Chicago, Chicago, IL 60637, USA
    BMC Bioinformatics 9:522. 2008
    ..To understand the cell cycle process, it is important to identify the cell cycle transcription factors (TFs) that regulate the expression of cell cycle-regulated genes...
  47. ncbi Proneural gene ash1 promotes amacrine cell production in the chick retina
    Weiming Mao
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Dev Neurobiol 69:88-104. 2009
    ..To better understand how neural diversity is achieved during retinal neurogenesis, we examined the function of ash1, a proneural bHLH gene expressed in progenitor cells throughout retinal neurogenesis...
  48. ncbi Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression
    Yujiro Tanaka
    Genome Structure and Regulation, School of Biomedical Science and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e28171. 2011
    Hox genes play important roles in haematopoietic development in mammals. ASH1 is a member of the trithorax group (trxG) that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells...
  49. ncbi dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development
    Graham Hallson
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Genetics 190:91-100. 2012
    ..but not in animals carrying mutations in genes encoding other well-characterized H3K4 HMTs such as trr, trx, and ash1. The latter results suggest that Trr, Trx, and Ash1 may play more specific roles in regulating key cellular targets ..
  50. ncbi Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2
    D Lajeunesse
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Mech Dev 53:123-39. 1995
    ..According to genetic criteria, the Drosophila melanogaster genes absent, small, or homeotic discs 1 and 2 (ash1 and ash2) are members of the trithorax group...
  51. ncbi The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes
    L O Baumbusch
    Division of Molecular Biology, Department of Biology, University of Oslo, PO Box 1031 Blindern, N 0315 Norway
    Nucleic Acids Res 29:4319-33. 2001
    ..These proteins can be divided into four classes as typified by their Drosophila members E(Z), TRX, ASH1 and SU(VAR)3-9. Homologs of all four classes have been identified in yeast and mammals, but not in plants...
  52. ncbi High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span
    G Landis
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Genetics 158:1167-76. 2001
    ..Mutations characterized included inserts in the alpha-mannosidase II (dGMII), ash1, and pumilio genes...
  53. ncbi Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs1 (ash1)
    N A Tripoulas
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    Genetics 137:1027-38. 1994
    The absent, small or homeotic discs1 gene (ash1) is one of the trithorax set of genes...
  54. ncbi Pre-mRNA processing factors are required for nuclear export
    A S Brodsky
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and the Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    RNA 6:1737-49. 2000
    ..Moreover, when export is blocked, only RNAs containing the ASH1 3' UTR accumulated in the nucleolus...
  55. ncbi Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion
    X Pan
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 20:8364-72. 2000
    ..By genome array and Northern analysis, we found that genes encoding the transcription factors Phd1, Ash1, and Swi5 were all induced in sok2/sok2 hyperfilamentous mutants...
  56. ncbi She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p
    F Bohl
    ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    EMBO J 19:5514-24. 2000
    RNA localization is a widespread mechanism to achieve localized protein synthesis. In budding yeast, localization of ASH1 mRNA controls daughter cell-specific accumulation of the transcriptional regulator Ash1p, which determines mating ..
  57. ncbi huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions
    T Nakamura
    Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 97:7284-9. 2000
    ..trithorax (trx)and ash1 (absent, small, or homeotic 1) are members of the Drosophila trx group...
  58. ncbi Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 19:351-7. 2000
    ..and in vitro 'pull down' techniques to show self association of the SET motifs of ALL-1, TRITHORAX and ASH1 proteins (Drosophila ASH1 is encoded by a trithorax-group gene)...
  59. ncbi The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
    I Stec
    MGC Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 473:1-5. 2000
    ..a gene mapping to the Wolf-Hirschhorn syndrome critical region and at its C-terminus similar to the Drosophila ASH1/trithorax group proteins, we identified a novel protein domain designated PWWP domain...
  60. ncbi Unconventional myosins and the genetics of hearing loss
    T B Friedman
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20854, USA
    Am J Med Genet 89:147-57. 1999
    ..The discovery that the mouse shaker1 (Myo7(ash1)) locus encodes myosin VIIA led immediately to the identification of mutations in this gene in Usher syndrome type ..
  61. ncbi The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans
    H M Chamberlin
    Department of Genetics, University of Washington, Seattle, WA 98195 7360, USA
    Development 127:713-23. 2000
    ..most similar to the human bromodomain protein BR140, and LIN-59 is most similar to the Drosophila trx-G protein ASH1. In C...
  62. ncbi Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 19:6441-7. 1999
    Trithorax (TRX) and ASH1 belong to the trithorax group (trxG) of transcriptional activator proteins, which maintains homeotic gene expression during Drosophila development...
  63. ncbi Association of the class V myosin Myo4p with a localised messenger RNA in budding yeast depends on She proteins
    S Münchow
    ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    J Cell Sci 112:1511-8. 1999
    ..Myo4p is required for the localisation of ASH1 mRNA, encoding a transcriptional repressor that is essential for differential expression of the HO gene and mating ..
  64. ncbi Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3
    I Pribill
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Somat Cell Mol Genet 23:413-27. 1997
    ..and several anonymous transcripts, including a putative novel DNA polymerase and a gene related to Drosophila ash1. While most of the genes in the region have been found, our data suggest that even with the entire DNA sequence ..
  65. ncbi Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae
    S Chandarlapaty
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599 7260, USA
    Mol Cell Biol 18:2884-91. 1998
    b>Ash1 (for asymmetric synthesis of HO) was first uncovered in genetic screens that revealed its role in mating-type switching. Ash1 prevents HO expression in daughter cells...
  66. ncbi Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast
    P A Takizawa
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:90-3. 1997
    ..The protein Ash1 is a cell-fate determinant in budding yeast which localizes preferentially to the presumptive daughter nucleus, ..
  67. ncbi Molecular genetic analysis of Drosophila ash2, a member of the trithorax group required for imaginal disc pattern formation
    A L Adamson
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 144:621-33. 1996
    ..called a PHD finger, that is present not only in the products of other trithorax group genes such as TRX and ASH1, but also in the product of a Polycomb group gene, PCL...
  68. ncbi She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae
    Hirofumi Toi
    Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University Graduate School of Medicine, Japan
    Mol Biol Cell 14:2237-49. 2003
    ..protein family, is required for endocytosis, polarization of actin cytoskeleton, and polarization of ASH1 mRNA in Saccharomyces cerevisiae...
  69. ncbi Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex
    Michael J Carrozza
    Stowers Institute for Medical Research1000 East 50th Street, Kansas City, MO 64110, USA
    Biochim Biophys Acta 1731:77-87; discussion 75-6. 2005
    Histone deacetylation by Saccharomyces cerevisiae Rpd3 represses genes regulated by the Ash1 and Ume6 DNA-binding proteins. Rpd3 exists in a small 0.6 MDa (Rpd3S) and large 1.2 MDa (Rpd3L) corepressor complex...
  70. ncbi ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features
    Hirotaka Osada
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Chikusa, Nagoya, Japan
    Cancer Res 65:10680-5. 2005
    ..The basic helix-loop-helix protein, achaete-scute complex-like 1/achaete-scute homologue 1 (ASH1), is expressed in normal fetal pulmonary neuroendocrine cells and lung cancers with neuroendocrine elements and is ..
  71. ncbi A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization
    Wei Gu
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 18:1452-65. 2004
    ..The accumulation of Ash1p results from ASH1 mRNA that is sorted as a ribonucleoprotein particle (mRNP or locasome) to the distal tip of the bud where ..
  72. ncbi RNA localization in yeast: moving towards a mechanism
    Graydon B Gonsalvez
    Department of Genetics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Biol Cell 97:75-86. 2005
    ..The mechanism by which the mRNAs are trafficked to the bud, illustrated by ASH1 mRNA, involves recognition of cis-acting localization elements present in the mRNA by the RNA-binding protein, ..
  73. ncbi Daughter-specific repression of Saccharomyces cerevisiae HO: Ash1 is the commander
    Maria Pia Cosma
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
    EMBO Rep 5:953-7. 2004
    The GATA-1-like factor Ash1 is a repressor of the HO gene, which encodes an endonuclease that is responsible for mating-type switching in the yeast Saccharomyces cerevisiae...
  74. ncbi Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae
    Paula Estrada
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA
    J Cell Biol 163:1255-66. 2003
    Myo4p is a nonessential type V myosin required for the bud tip localization of ASH1 and IST2 mRNA. These mRNAs associate with Myo4p via the She2p and She3p proteins. She3p is an adaptor protein that links Myo4p to its cargo...
  75. ncbi Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud
    Zhifa Shen
    Departement de Biochimie, Université de Montréal Montréal, Quebec H3C 3J7 Canada
    Genes Dev 24:1914-26. 2010
    ..Here we report that She2p is recruited cotranscriptionally to the nascent bud-localized ASH1, IST2, and EAR1 mRNA...
  76. ncbi Achaete-scute homologue-1 tapers neuroendocrine cell differentiation in lungs after exposure to naphthalene
    Sandra Jensen-Taubman
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Sci 117:238-48. 2010
    The basic helix-loop-helix transcription factor achaete-scute homologue-1 (ASH1) plays a critical role in regulating the neuroendocrine (NE) phenotype in normal and neoplastic lung...
  77. ncbi Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA
    R M Long
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 277:383-7. 1997
    ..Here it is shown that ASH1 messenger RNA (mRNA) preferentially accumulates in daughter cells by a process that is dependent on actin and ..
  78. ncbi The structure of the Myo4p globular tail and its function in ASH1 mRNA localization
    Alexander Heuck
    Institute of Structural Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
    J Cell Biol 189:497-510. 2010
    ..In Saccharomyces cerevisiae, the MyoV motor Myo4p interacts with She3p to localize asymmetric synthesis of HO 1 (ASH1) mRNA into the bud of dividing cells...
  79. ncbi The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes
    O Papoulas
    Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 125:3955-66. 1998
    ..biochemical evidence for the existence of two additional complexes containing trithorax group proteins: a 2 MDa ASH1 complex and a 500 kDa ASH2 complex...
  80. ncbi Functional and physical interactions within the middle domain of the yeast mediator
    Magnus Hallberg
    Department of Medical Biochemistry and Biophysics, Umea University, 0187, Umea, Sweden
    Mol Genet Genomics 276:197-210. 2006
    ..The three strongest suppressors were MED7 and MED10 (NUT2), which encode other Mediator subunits, and ASH1, which encodes a repressor of the HO gene...
  81. ncbi A putative function of the nucleolus in the assembly or maturation of specialized messenger ribonucleoprotein complexes
    Stephan Jellbauer
    Genecenter, Ludwig Maximilians Universitat Munchen, Munich, Germany
    RNA Biol 5:225-9. 2008
    ..Experimental evidence derived from studies on the nucleolar accumulation of yeast ASH1 mRNA and of cytoplasmic retention of its binding protein She2 are integrated into a hypothetical model that ..
  82. ncbi SWI/SNF binding to the HO promoter requires histone acetylation and stimulates TATA-binding protein recruitment
    Doyel Mitra
    Department of Pathology, University of Utah, 15 North Medical Drive East, Salt Lake City, UT 84132 2501, USA
    Mol Cell Biol 26:4095-110. 2006
    ..results showed that SWI/SNF binding to HO was Gcn5 independent, but that work used a strain with a mutation in the Ash1 daughter-specific repressor of HO expression...
  83. ncbi An achaete-scute homologue essential for neuroendocrine differentiation in the lung
    M Borges
    The Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 386:852-5. 1997
    ..Strikingly, newborn mice bearing a disruption of the ASH1 gene have no detectable pulmonary neuroendocrine cells...
  84. ncbi Asymmetric accumulation of Ash1p in postanaphase nuclei depends on a myosin and restricts yeast mating-type switching to mother cells
    N Bobola
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 84:699-709. 1996
    ..We describe a gene, ASH1, that is necessary to repress HO in daughters...
  85. ncbi Repressive chromatin affects factor binding at yeast HO (homothallic switching) promoter
    Shinya Takahata
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    J Biol Chem 286:34809-19. 2011
    ..The Rpd3(L) histone deacetylase is recruited to HO at two distinct times during the cell cycle, first by Ash1 to the URS1 region of the promoter and then by SBF/Whi5/Stb1 to URS2...
  86. ncbi Bi-polarized translation of ascidian maternal mRNA determinant pem-1 associated with regulators of the translation machinery on cortical Endoplasmic Reticulum (cER)
    Alexandre Paix
    Université Pierre et Marie Curie and Centre National de la Recherche Scientifique, BioMarCell, UMR BioDev, Observatoire Oceanologique, Villefranche sur Mer, France
    Dev Biol 357:211-26. 2011
    ..cortical mRNA determinants such as maternal macho-1 and pem-1 in ascidians, like budding yeast mating factor ASH1 reside on the cER-mRNA domain a subdomain of cortical Endoplasmic Reticulum(ER) and are translated in its vicinity...
  87. ncbi A cytoplasmic complex mediates specific mRNA recognition and localization in yeast
    Marisa Müller
    Institute of Structural Biology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Munchen, Germany
    PLoS Biol 9:e1000611. 2011
    ..We used ASH1-mRNA transport in yeast to provide a first assessment of where and how localizing mRNAs are specifically recognized ..
  88. ncbi The CW domain, a new histone recognition module in chromatin proteins
    Verena Hoppmann
    Department of Molecular Biology, University of Bergen, Bergen, Norway
    EMBO J 30:1939-52. 2011
    ..The solution structure of the CW domain of the Arabidopsis ASH1 HOMOLOG2 (ASHH2) histone methyltransferase provides insight into how different CW domains can distinguish different ..
  89. ncbi Identification of asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene
    A Sil
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 0448 USA
    Cell 84:711-22. 1996
    ..We have isolated a mutant in which daughters transcribe HO and switch mating type. This mutation defines the ASH1 gene (asymmetric synthesis of HO)...
  90. ncbi The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger
    N Tripoulas
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 143:913-28. 1996
    ..The stability of these patterns requires the function of the ash1 gene, a member of the trithorax group. The primary translation product of the 7...
  91. ncbi SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor
    Qingquan Liu
    School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 31:584-98. 2011
    ..which initiates the interconversion of a and α mating type cassettes, is extinguished by the daughter-specific Ash1 transcriptional repressor...
  92. ncbi A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae
    Erin A Powrie
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    RNA 17:134-44. 2011
    ..Importantly, downstream processes were also affected. Localization of ASH1 and IST2 mRNAs to the bud was impaired in the Δnup60 background, suggesting that the assembly of a localization ..
  93. ncbi PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex
    Yui Jin
    Life Sciences Institute, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Mol Biol Cell 20:1312-23. 2009
    ..These include peroxisomes, secretory vesicles, cargoes of Myo2p, and ASH1 mRNA, a cargo of Myo4p. We find that Ptc1p is required for the proper distribution of both Myo2p and Myo4p...
  94. ncbi Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit
    Carl R Urbinati
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Genet Genomics 276:369-77. 2006
    Loc1p is an exclusively nuclear dsRNA-binding protein that affects the asymmetric sorting of ASH1 mRNA to daughter cells in Saccharomyces cerevisiae...
  95. ncbi Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers
    F Bantignies
    Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:9317-30. 2000
    ..phenotype were identified: the PKA-C1/DCO gene, encoding the catalytic subunit of cyclic AMP protein kinase, and ash1, a member of the trithorax group (trxG) of chromatin modifiers...
  96. ncbi She2p is a novel RNA-binding protein that recruits the Myo4p-She3p complex to ASH1 mRNA
    R M Long
    Medical College of Wisconsin, Department of Microbiology and Molecular Genetics, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    EMBO J 19:6592-601. 2000
    ..of transcription that localizes exclusively to daughter cell nuclei through the asymmetric localization of ASH1 mRNA...
  97. ncbi Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1
    E Ferretti
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Endocrinol Invest 26:957-65. 2003
    ..Members of bHLH family include NeuroD1 and ASH1, both involved in neuroendocrine differentiation...
  98. ncbi Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax
    Tilman Sanchez-Elsner
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Science 311:1118-23. 2006
    ..homeotic gene Ultrabithorax (Ubx) mediate transcription activation by recruiting the epigenetic regulator Ash1 to the template TREs...
  99. ncbi Human ASH1 expression in prostate cancer with neuroendocrine differentiation
    Ida Rapa
    Division of Pathology, Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Turin, Italy
    Mod Pathol 21:700-7. 2008
    ..Human ASH1 protein was analyzed by immunohistochemistry, whereas the presence of hASH1 mRNA transcripts was investigated on ..
  100. ncbi RNA-protein interactions promote asymmetric sorting of the ASH1 mRNA ribonucleoprotein complex
    Graydon B Gonsalvez
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    RNA 9:1383-99. 2003
    In Saccharomyces cerevisiae, ASH1 mRNA is localized to the tip of daughter cells during anaphase of the cell cycle. ASH1 mRNA localization is dependent on four cis-acting localization elements as well as Myo4p, She2p, and She3p...
  101. ncbi Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
    Christian Beisel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Nature 419:857-62. 2002
    ..Here we show that the epigenetic activator Ash1 (ref...

Research Grants66

  1. Mechanism of mRNA transport by Myo4p
    Peter Takizawa; Fiscal Year: 2009
    ..To address these questions, this proposal will analyze how Myo4p transports ASH1 mRNA to the bud tip in S. cerevisiae...
  2. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2005
    ..While the mechanism responsible for asymmetric localization of Ash1 has been elucidated, very little is known about the daughter-specific program that it mediates to establish the PH ..
  3. Biochemistry and Structure of RNA-Protein Complexes
    James Williamson; Fiscal Year: 2006
    ..RNA-protein complex involved in localization and translational regulation of the Saccharomyces cerevesiae ASH1 mRNA. ASH1 is localized to the tip of a budding daughter cell, and the ASH1 protein regulates mating type switching...
  4. An E3 Ubiquitin Ligase Complex That Regulates C. elegans Developmental Timing
    Adam Antebi; Fiscal Year: 2009
    ..3. characterize putative targets of DRE-1, including the trithorax protein LIN- 59/ASH1. lin-59 mutant defects, genetic interactions, expression pattern and regulation will be determined...
  5. An E3 Ubiquitin Ligase Complex That Regulates C. elegans Developmental Timing
    Adam Antebi; Fiscal Year: 2007
    ..3. characterize putative targets of DRE-1, including the trithorax protein LIN- 59/ASH1. lin-59 mutant defects, genetic interactions, expression pattern and regulation will be determined...
  6. The switch between epigenetically silenced and active chromatin states
    Vincenzo Pirrotta; Fiscal Year: 2010
    ..Trithorax and ASH1 proteins are necessary to switch genes to an epigenetic active state and to antagonize Polycomb silencing...
  7. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert H Singer; Fiscal Year: 2010
    ..yeast Saccharomyces cerevisiae, mating type switching is tightly controlled by the asymmetric accumulation of the ASH1 gene product...
  8. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2007
    ..yeast Saccharomyces cerevisiae, mating type switching is tightly controlled by the asymmetric accumulation of the ASH1 gene product...
  9. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2006
    ..The synthesis ofbeta-actin at the leading edge facilitates cell polarity and motility. In yeast, ASH1 mRNA localizes to the bud tip and is necessary for asymmetric gene expression between the mother and the bud, ..
  10. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2003
    ..The synthesis ofbeta-actin at the leading edge facilitates cell polarity and motility. In yeast, ASH1 mRNA localizes to the bud tip and is necessary for asymmetric gene expression between the mother and the bud, ..
  11. MOLECULAR BASIS OF DROSOPHILA HOMEOTIC GENE REGULATION
    Peter J Harte; Fiscal Year: 2010
    ..including involvement in reversing Polycomb silencing at the onset of differentiation 3) investigate whether ASH1 also mediates H3K27 acetylation through its known association with CBP...
  12. RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITU
    Robert Singer; Fiscal Year: 2001
    ..I. proposes a series of aims designed to address the localization of ASH1 mRNA in yeast cells...
  13. A NEURAL TRANSCRIPTION FACTOR IN LUNG CANCER EVOLUTION
    Douglas Ball; Fiscal Year: 2003
    ..In mammalian development, ASH1 (termed MASH1 in rodents) is essential for normal differentiation of sympathoadrenal, enteric, olfactory, retinal, ..
  14. A Molecular Basis for Neuroendocrine Carcinogenesis
    H Grimes; Fiscal Year: 2007
    ..oncoprotein and the basic helix-loop-helix (bHLH) transcription factor human achaete and scute homolog- 1 (ASH1) are modifiers of SCLC because they control neuroendocrine differentiation of lung epithelium...
  15. A Molecular Basis for Neuroendocrine Carcinogenesis
    H Grimes; Fiscal Year: 2009
    ..oncoprotein and the basic helix-loop-helix (bHLH) transcription factor human achaete and scute homolog- 1 (ASH1) are modifiers of SCLC because they control neuroendocrine differentiation of lung epithelium...
  16. RNA LOCALIZATION IN S.CEREVISIAE
    ROY LONG; Fiscal Year: 2004
    ..The yeast S. cerevisiae serves as a model system for studying the asymmetric segregation of mRNA. ASH1 mRNA is localized to the distal end of daughter cells during anaphase of the cell cycle, resulting in the exclusive ..
  17. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    JOHN TAMKUN; Fiscal Year: 2009
    ..Our studies of chromatin-remodeling factors in a genetic model organism should therefore shed light on the molecular mechanisms underlying these human cancers and other diseases. ..
  18. GENETIC/BIOCHEM STUDIES OF CHROMATIN REMODELING FACTORS
    JOHN TAMKUN; Fiscal Year: 2000
    ..The ability to conduct genetic studies of chromatin remodeling factors in Drosophila thus represents an excellent opportunity to increase our understanding of their roles in transcription, development and disease. ..
  19. Studies of Chromatin Remodeling Factors
    JOHN TAMKUN; Fiscal Year: 2004
    ..Thus, the information gained from the study of chromatin remodeling factors in Drosophila should be directly relevant to human disease. ..
  20. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    JOHN WALTER TAMKUN; Fiscal Year: 2010
    ..The information gained from this project will therefore be directly relevant to human health. ..
  21. Molecular-genetic analysis of the Drosophila CNS midline
    SCOTT WHEELER; Fiscal Year: 2007
    ..Through the combination of descriptive and functional-genetic studies I will begin to dissect the molecular and genetic pathways that control the development and differentiation midline neurons. ..
  22. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    JOHN TAMKUN; Fiscal Year: 2007
    ..Our studies of chromatin-remodeling factors in a genetic model organism should therefore shed light on the molecular mechanisms underlying these human cancers and other diseases. ..
  23. REGULATION OF GENE EXPRESSION DURING ORGANOGENESIS
    Helen Chamberlin; Fiscal Year: 2004
    ..elegans. A third aim is to functionally characterize this second gene to determine whether its product shares in vivo functions with EGL-38, or whether it regulates lin-48 and cdh-3 expression in other organs. ..