ASF1A

Summary

Gene Symbol: ASF1A
Description: anti-silencing function 1A histone chaperone
Alias: CGI-98, CIA, HSPC146, histone chaperone ASF1A, ASF1 anti-silencing function 1 homolog A, CCG1-interacting factor A, anti-silencing function protein 1 homolog A, hAsf1, hAsf1a, hCIA
Species: human
Products:     ASF1A

Top Publications

  1. Zhang R, Chen W, Adams P. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol. 2007;27:2343-58 pubmed
    ..we showed that a complex of histone chaperones, histone repressor A (HIRA) and antisilencing function 1a (ASF1a), plays a key role in the formation of SAHF...
  2. Groth A, Corpet A, Cook A, Roche D, Bartek J, Lukas J, et al. Regulation of replication fork progression through histone supply and demand. Science. 2007;318:1928-31 pubmed
  3. Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010;24:1253-65 pubmed publisher
    ..Taken together, our data demonstrate that DAXX functions as a bona fide histone chaperone involved in the replication-independent deposition of H3.3. ..
  4. Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K. Transcriptional regulation of human chromatin assembly factor ASF1. DNA Cell Biol. 2007;26:91-9 pubmed
    ..Here, we report the identification of human ASF1B, but not ASF1A, as a direct transcriptional target of transcription factor E2F1...
  5. Galvani A, Courbeyrette R, Agez M, Ochsenbein F, Mann C, Thuret J. In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells. Mol Cell Biol. 2008;28:3672-85 pubmed publisher
    ..Here, we identify mutants of histones H3.1 and H3.3 that are unable to interact with human ASF1A and ASF1B isoforms but that are still competent to bind CAF-1 and HIRA, respectively...
  6. Mello J, Sillje H, Roche D, Kirschner D, Nigg E, Almouzni G. Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. EMBO Rep. 2002;3:329-34 pubmed
    ..Furthermore, we demonstrate that hAsf1 proteins can interact directly with the p60 subunit of hCAF-1...
  7. Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J. 2012;31:2013-23 pubmed publisher
    ..This function is compromised by two CDAI mutations that impair complex formation with Asf1, providing insight into the molecular basis for CDAI disease. ..
  8. Jiang W, Nguyen A, Cao Y, Chang A, Reddel R. HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. PLoS ONE. 2011;6:e17036 pubmed publisher
    ..Here we investigated the mechanism of HP1-mediated APB formation, and found that histone chaperones, HIRA and ASF1a, are present in APBs following activation of the p53/p21 pathway in ALT cells...
  9. Groth A, Ray Gallet D, Quivy J, Lukas J, Bartek J, Almouzni G. Human Asf1 regulates the flow of S phase histones during replicational stress. Mol Cell. 2005;17:301-11 pubmed
    ..While in unperturbed S phase, hAsf1 existed in equilibrium between an active form and an inactive histone-free pool, replication stress mobilized the ..

More Information

Publications73

  1. Zhang R, Poustovoitov M, Ye X, Santos H, Chen W, Daganzo S, et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell. 2005;8:19-30 pubmed
    ..A physical complex containing HIRA and another chromatin regulator, ASF1a, is rate limiting for formation of SAHF and onset of senescence, and ASF1a is required for formation of SAHF and ..
  2. Pilyugin M, Demmers J, Verrijzer C, Karch F, Moshkin Y. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. PLoS ONE. 2009;4:e8328 pubmed publisher
    ..Loss of TLK-mediated phosphorylation triggers hASF1a and dASF1 degradation by proteasome-dependent and independent mechanisms respectively...
  3. Tagami H, Ray Gallet D, Almouzni G, Nakatani Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell. 2004;116:51-61 pubmed
    ..This finding provides new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication. ..
  4. Groth A, Lukas J, Nigg E, Sillje H, Wernstedt C, Bartek J, et al. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J. 2003;22:1676-87 pubmed
  5. Zhang W, Tyl M, Ward R, Sobott F, Maman J, Murthy A, et al. Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1. Nat Struct Mol Biol. 2013;20:29-35 pubmed publisher
  6. Silljé H, Nigg E. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. Curr Biol. 2001;11:1068-73 pubmed
    ..These data indicate that Tlk family members regulate chromatin assembly during DNA replication, and they suggest a plausible explanation for the pleiotropic developmental defects of plant tousled mutants. ..
  7. Emili A, Schieltz D, Yates J, Hartwell L. Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. Mol Cell. 2001;7:13-20 pubmed
    ..Biochemical and molecular genetic studies suggest that Asf1 is an important target of the Rad53-dependent DNA damage response and that Rad53 may directly regulate chromatin assembly during DNA replication and repair. ..
  8. Jasencakova Z, Scharf A, Ask K, Corpet A, Imhof A, Almouzni G, et al. Replication stress interferes with histone recycling and predeposition marking of new histones. Mol Cell. 2010;37:736-43 pubmed publisher
    ..During recovery, histones stored with Asf1 are rapidly used as replication resumes. This shows that replication stress interferes with predeposition marking and histone recycling with potential impact on epigenetic stability. ..
  9. Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, et al. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol. 2009;29:758-70 pubmed publisher
    ..Formation of SAHF in human cells is driven by a complex of histone chaperones, namely, HIRA and ASF1a. In yeast, the complex orthologous to HIRA/ASF1a contains two additional proteins, Hpc2p and Hir3p...
  10. Natsume R, Eitoku M, Akai Y, Sano N, Horikoshi M, Senda T. Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4. Nature. 2007;446:338-41 pubmed
    ..Human CIA-I/II (ASF1a/b) was identified as a histone chaperone that interacts with the bromodomain-an acetylated-histone-recognizing ..
  11. Mousson F, Lautrette A, Thuret J, Agez M, Courbeyrette R, Amigues B, et al. Structural basis for the interaction of Asf1 with histone H3 and its functional implications. Proc Natl Acad Sci U S A. 2005;102:5975-80 pubmed
    ..We solved the NMR solution structure of the N-terminal functional domain of the human Asf1a isoform, and we identified by NMR chemical shift mapping a surface of Asf1a that binds the C-terminal helix of ..
  12. Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M. A human homologue of yeast anti-silencing factor has histone chaperone activity. Genes Cells. 2000;5:221-33 pubmed
    ..Here we report the functional activity of a highly evolutionarily conserved human factor termed CIA (CCG1-interacting factor A), whose budding yeast homologue ASF1 has anti-silencing activity...
  13. Agez M, Chen J, Guerois R, van Heijenoort C, Thuret J, Mann C, et al. Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights. Structure. 2007;15:191-9 pubmed
    ..We solved the structure of the conserved domain of human ASF1A in complex with the C-terminal helix of histone H3 using nuclear magnetic resonance spectroscopy...
  14. Umehara T, Horikoshi M. Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. J Biol Chem. 2003;278:35660-7 pubmed
    ..We found that human CIA-II (hCIA-II) localizes in HeLa nuclei and is highly expressed in testis and other proliferating cell-containing tissues...
  15. Tang Y, Poustovoitov M, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, et al. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006;13:921-9 pubmed
    Human HIRA, ASF1a, ASF1b and CAF-1 are evolutionally conserved histone chaperones that form multiple functionally distinct chromatin-assembly complexes, with roles linked to diverse nuclear process, such as DNA replication and formation ..
  16. Herman S, Fischer A, Presumey J, Hoffmann M, Koenders M, Escriou V, et al. Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis. Arthritis Rheumatol. 2015;67:2536-46 pubmed publisher
    ..Collagen-induced arthritis (CIA) and the K/BxN serum-transfer model were used as animal models of RA...
  17. Prud homme G, Glinka Y, Wang Q. Immunological GABAergic interactions and therapeutic applications in autoimmune diseases. Autoimmun Rev. 2015;14:1048-56 pubmed publisher
    ..against type 1 diabetes (T1D), experimental autoimmune encephalomyelitis (EAE), collagen-induced arthritis (CIA) and contact dermatitis...
  18. Mateen S, Shahzad S, Ahmad S, Naeem S, Khalid S, Akhtar K, et al. Cinnamaldehyde and eugenol attenuates collagen induced arthritis via reduction of free radicals and pro-inflammatory cytokines. Phytomedicine. 2019;53:70-78 pubmed publisher
    ..scanning electron microscopic analysis were done to monitor the effect of compounds on collagen induced arthritis (CIA). Reactive oxygen species (ROS) formation, nitric oxide and antioxidant status were also determined...
  19. Hsiao H, Wu J, Lin W. Anti-arthritic and anti-inflammatory effects of (-)-Epicatechin-3-O-β-d-allopyranoside, a constituent of Davallia formosana. Phytomedicine. 2019;52:12-22 pubmed publisher
    ..the antiarthritic and the anti-inflammatory effect of ECAP on a mouse model of collagen-induced arthritis (CIA) and in vitro...
  20. Hsiao H, Hsieh C, Wu J, Lin H, Lin W. Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses. BMC Complement Altern Med. 2016;16:80 pubmed publisher
    ..effectively protected bone and cartilage of knee joint from erosion, lesion and deformation versus those from the CIA group...
  21. Xia G, Wang X, Sun H, Qin Y, Fu M. Carnosic acid (CA) attenuates collagen-induced arthritis in db/db mice via inflammation suppression by regulating ROS-dependent p38 pathway. Free Radic Biol Med. 2017;108:418-432 pubmed publisher
    ..Carnosic acid (CA) was used to treat collagen-induced arthritis (CIA)-induced db/db mice...
  22. Biniecka M, Connolly M, Gao W, Ng C, Balogh E, Gogarty M, et al. Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis. Arthritis Rheumatol. 2014;66:3300-10 pubmed publisher
    ..arthritis before and after receiving TNF inhibitor (TNFi) therapy and in mice with collagen-induced arthritis (CIA)...
  23. Tu Y, Wang K, Liang Y, Jia X, Wang L, Wan J, et al. Glycine tabacina ethanol extract ameliorates collagen-induced arthritis in rats via inhibiting pro-inflammatory cytokines and oxidation. J Ethnopharmacol. 2019;237:20-27 pubmed publisher
    ..tabacina (GTE) in a collagen-induced arthritis (CIA) rat model. The chemical profile of GTE was analyzed by HPLC-UV...
  24. Chukkapalli S, Rivera Kweh M, Gehlot P, Velsko I, Bhattacharyya I, Calise S, et al. Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice. Arthritis Res Ther. 2016;18:161 pubmed publisher
    ..we investigated the role of periodontal bacteria in induction of joint inflammation in collagen-induced arthritis (CIA) in B10.RIII mice. CIA-prone B10...
  25. Zhou L, Zeng W, Sun L, Wang Y, Jiang F, Li X, et al. IKKε aggravates inflammatory response via activation of NF-κB in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2018;22:2126-2133 pubmed publisher
    ..mechanism of IKKε (inhibitor of nuclear factor kappa-B kinase ε) in collagen II induced- Rheumatoid Arthritis (CIA) mice model...
  26. Caselli G, Bonazzi A, Lanza M, Ferrari F, Maggioni D, Ferioli C, et al. Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug. Arthritis Res Ther. 2018;20:39 pubmed publisher
    ..In collagen-induced arthritis (CIA) models, rats or mice were immunised with bovine collagen type II...
  27. Han J, Zhou Q, Li X, He J, Han Y, Jie H, et al. Novel function of hydroxychloroquine: Down regulation of T follicular helper cells in collagen-induced arthritis. Biomed Pharmacother. 2018;97:838-843 pubmed publisher
    ..In in vivo experiments of collagen-induced arthritis (CIA) model, we discovered that HCQ suppressed the incidence and score of arthritis, reduced the secretion of ..
  28. Zhao H, Xu H, Qiao S, Lu C, Wang G, Liu M, et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017;51:114-123 pubmed publisher
    To investigate the effect of boldine isolated from Litsea cubeba on collagen-induced arthritis (CIA) rats and explore the molecular mechanism predicted by network pharmacology. CIA rats were orally administered with boldine...
  29. Odermatt D, Gari K. The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins. Cell Rep. 2017;18:1434-1443 pubmed publisher
    The cytoplasmic iron-sulfur assembly (CIA) targeting complex is required for the transfer of an iron-sulfur (Fe-S) cluster to cytoplasmic and nuclear proteins, but how it engages with client proteins is unknown...
  30. Al Hadethi S, Fernando S, Hughes S, Thakorlal A, Seruga A, Scurry B. Does temproray bilateral balloon occlusion of the common iliac arteries reduce the need for intra-operative blood transfusion in cases of placenta accretism?. J Med Imaging Radiat Oncol. 2017;61:311-316 pubmed publisher
    ..The objective of this study was to assess the efficacy of bilateral balloon occlusion of the common iliac arteries (CIA) in reducing intra-operative morbidity in cases of placenta accretism.
  31. Richet N, Liu D, Legrand P, Velours C, Corpet A, Gaubert A, et al. Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork. Nucleic Acids Res. 2015;43:1905-17 pubmed publisher
    ..This suggests an additional function for MCM2 outside its helicase function as a proper histone chaperone connected to the replication pathway. ..
  32. O Sullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014;21:167-74 pubmed publisher
    ..We have now discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary and cancer cells...
  33. Boccia R, Henry D, Belton L, Bohac C, Ghazal H. Efficacy and safety of darbepoetin alfa initiated at hemoglobin ≤10 g/dL in patients with stage IV cancer and chemotherapy-induced anemia. Cancer Med. 2016;5:3445-3453 pubmed publisher
    ..analysis, we examined DA's efficacy and safety in patients with Stage IV cancers and chemotherapy-induced anemia (CIA) initiated on DA at Hb ≤10 g/dL...
  34. Saha P, Vishwanathan V, Bankapalli K, D Silva P. Iron-Sulfur Protein Assembly in Human Cells. Rev Physiol Biochem Pharmacol. 2018;174:25-65 pubmed publisher
    ..mitochondrial iron-sulfur cluster (ISC) assembly and export system along with the cytosolic Fe-S cluster assembly (CIA) machinery...
  35. Le Huec J, Richards J, Tsoupras A, Price R, Léglise A, Faundez A. The mechanism in junctional failure of thoraco-lumbar fusions. Part I: Biomechanical analysis of mechanisms responsible of vertebral overstress and description of the cervical inclination angle (CIA). Eur Spine J. 2018;27:129-138 pubmed publisher
    ..Also, a new angle, the cervical inclination angle (CIA), describing the relative position of the head at each vertebral level, is presented...
  36. Su X, Li T, Liu Z, Huang Q, Liao K, Ren R, et al. Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349. Free Radic Biol Med. 2018;115:471-483 pubmed publisher
    ..of SQSTM1 (p62)/nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling in the collagen-induced arthritis (CIA) model of DBA mice...
  37. Sun G, Hou Y, Gong W, Liu S, Li J, Yuan Y, et al. Adoptive Induced Antigen-Specific Treg Cells Reverse Inflammation in Collagen-Induced Arthritis Mouse Model. Inflammation. 2018;41:485-495 pubmed publisher
    ..proved that the adoptive transfer of these antigen-specific Treg cells reversed the collagen-induced arthritis (CIA) progression by suppressing the key inflammatory cytokine TNF-α...
  38. Shah V, Wikramanayake T, DelCanto G, van den Hurk C, Wu S, Lacouture M, et al. Scalp hypothermia as a preventative measure for chemotherapy-induced alopecia: a review of controlled clinical trials. J Eur Acad Dermatol Venereol. 2017;: pubmed publisher
    Chemotherapy-induced alopecia (CIA) is a temporary, yet psychologically devastating form of hair loss that affects 65% of patients receiving cancer chemotherapy...
  39. Lee K, Im J, Shibata E, Dutta A. ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks. Mol Cell. 2017;68:61-75.e5 pubmed publisher
    ..The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and ..
  40. Im J, KEATON M, Lee K, Kumar P, Park J, Dutta A. ATR checkpoint kinase and CRL1?TRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks. Genes Dev. 2014;28:875-87 pubmed publisher
    ..The ATR checkpoint pathway causes a histone chaperone normally associated with the replication fork, ASF1a, to degrade through a CRL1(?TRCP)-dependent ubiquitination/proteasome pathway, leading to the localized ..
  41. Wang H, Wang M, Yang N, Xu R. Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Protein Cell. 2015;6:693-7 pubmed publisher
  42. Dunnill C, Al Tameemi W, Collett A, Haslam I, Georgopoulos N. A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention. Oncologist. 2018;23:84-96 pubmed publisher
    Chemotherapy-induced alopecia (CIA) is the most visibly distressing side effect of commonly administered chemotherapeutic agents...
  43. Moschovakis G, Bubke A, Friedrichsen M, Falk C, Feederle R, Forster R. T cell specific Cxcr5 deficiency prevents rheumatoid arthritis. Sci Rep. 2017;7:8933 pubmed publisher
    ..Employing collagen-induced arthritis (CIA) we identify CXCR5 as an absolutely essential factor for the induction of inflammatory autoimmune arthritis...
  44. Klimovskaia I, Young C, Strømme C, Menard P, Jasencakova Z, Mejlvang J, et al. Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication. Nat Commun. 2014;5:3394 pubmed publisher
    ..The divergent C-terminal tail of Asf1a is phosphorylated at several sites, and this is required for timely progression through S phase...
  45. Wang K, Dunkley L, Neale M. Novel Endovascular Approach Using the Gore Iliac Branch Endograft for Short Iliac Anatomy. J Endovasc Ther. 2017;:1526602817746127 pubmed publisher
    To report the use of a branched iliac endograft to maintain internal iliac artery (IIA) patency in a patient with an infrarenal aortic aneurysm and short common iliac arteries (CIA).
  46. Li Z, Tan J, Wang L, Li Q. Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways. Inflammation. 2017;40:1599-1605 pubmed publisher
    ..In this study, we investigated the effects of AD on collagen-induced arthritis (CIA) and human RA synovial fibroblasts (RA-SFs). CIA mice were treated with AD (dissolved in 0...
  47. Vo A, Fleischman N, Marquez M, Camire E, Esonwune S, Grossman J, et al. Defining the domains of Cia2 required for its essential function in vivo and in vitro. Metallomics. 2017;9:1645-1654 pubmed publisher
    The cytosolic iron-sulfur cluster assembly (CIA) system biosynthesizes iron-sulfur (FeS) cluster cofactors for cytosolic and nuclear proteins...
  48. Chen X, Kuang N, Zeng X, Zhang Z, Li Y, Liu W, et al. Effects of daphnetin combined with Bcl2?siRNA on antiapoptotic genes in synovial fibroblasts of rats with collagen?induced arthritis. Mol Med Rep. 2018;17:884-890 pubmed publisher
    ..si?Bcl2) on antiapoptotic genes in fibroblast?like synoviocytes (FLS) in rats with collagen II?induced arthritis (CIA). The roles of si?Bcl2 and daphnetin were determined by measuring the expression levels of Bcl2...
  49. Netz D, Genau H, Weiler B, Bill E, Pierik A, Lill R. The conserved protein Dre2 uses essential [2Fe-2S] and [4Fe-4S] clusters for its function in cytosolic iron-sulfur protein assembly. Biochem J. 2016;473:2073-85 pubmed publisher
    The cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery comprises 11 essential components and matures Fe-S proteins involved in translation and genome maintenance...
  50. Tolic N, Liu Y, Liyu A, Shen Y, Tfaily M, Kujawinski E, et al. Formularity: Software for Automated Formula Assignment of Natural and Other Organic Matter from Ultrahigh-Resolution Mass Spectra. Anal Chem. 2017;: pubmed publisher
    ..A Compound Identification Algorithm (CIA) was previously developed for automated elemental formula assignment for natural organic matter (NOM)...
  51. Loney G, Meyer P. Brief exposures to the taste of ethanol and quinine promote subsequent acceptance of ethanol in a paradigm that minimizes post-ingestive consequences. Alcohol Clin Exp Res. 2017;: pubmed publisher
    ..Chronic-intermittent ethanol access (CIA) results in substantial and persistent increases in ethanol consumption, but the degree to which this facilitation ..
  52. Lim M, Louie B, Ford D, Heath K, Cha P, Betts LaCroix J, et al. Development of the Digital Arthritis Index, a Novel Metric to Measure Disease Parameters in a Rat Model of Rheumatoid Arthritis. Front Pharmacol. 2017;8:818 pubmed publisher
    ..As a proof-of-concept, we utilized the rat collagen-induced arthritis (CIA) model of RA and developed the Digital Arthritis Index (DAI), an objective and automated behavioral metric that ..
  53. Akai Y, Adachi N, Hayashi Y, Eitoku M, Sano N, Natsume R, et al. Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction. Proc Natl Acad Sci U S A. 2010;107:8153-8 pubmed publisher
    ..the crystal structure of histone chaperone cell cycle gene 1 (CCG1) interacting factor A/antisilencing function 1 (CIA/ASF1) in complex with the double bromodomain in the CCG1/TAF1/TAF(II)250 subunit of transcription factor IID...
  54. Lee S, Lee S, Park S, Kim D, Kim E, Kim J, et al. (p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice. Immunol Lett. 2016;176:36-43 pubmed publisher
    ..In this study, we intraperitoneally injected (p40)2-Fc into collagen induced arthritis (CIA) mice to identify whether (p40)2-Fc attenuates CIA severity...
  55. Kuipers J, Zeidler H, Köhler L. How does Chlamydia cause arthritis?. Rheum Dis Clin North Am. 2003;29:613-29 pubmed
    Because the bacterial cause of CIA has been identified and proven to persist at the site of inflammation, the understanding of how Chlamydia cause arthritis has made much progress...
  56. Rossi A, Fortuna M, Caro G, Pranteda G, Garelli V, Pompili U, et al. Chemotherapy-induced alopecia management: Clinical experience and practical advice. J Cosmet Dermatol. 2017;16:537-541 pubmed publisher
    Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians...
  57. Walker M, Zhang M, Le T, Wu P, Laine M, Greene G. RAC3 is a pro-migratory co-activator of ER?. Oncogene. 2011;30:1984-94 pubmed publisher
    ..In conclusion, RAC3 is a novel ER? co-activator that promotes cell migration and has prognostic value for ER?-positive breast cancer metastasis. RAC3 may also be a useful therapeutic target for ER?-positive breast cancers. ..
  58. Liang X, Yuan X, Yu J, Wu Y, Li K, Sun C, et al. Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes. EBioMedicine. 2017;21:104-116 pubmed publisher
    ..However, the histone H3-H4 chaperone ASF1A is an important factor regulating chromatin assembling and gene transcription, while it is currently unclear ..
  59. Ito H, Noda K, Yoshida K, Otani K, Yoshiga M, Oto Y, et al. Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis. BMC Musculoskelet Disord. 2016;17:387 pubmed publisher
    Prokineticin 2 (PK2) expression is upregulated in mice with collagen-induced arthritis (CIA), an animal model of rheumatoid arthritis. The purpose of our study was to investigate the effects of PK2 inhibition on CIA...
  60. Kiyeko G, Hatterer E, Herren S, Di Ceglie I, van Lent P, Reith W, et al. Spatiotemporal expression of endogenous TLR4 ligands leads to inflammation and bone erosion in mouse collagen-induced arthritis. Eur J Immunol. 2016;46:2629-2638 pubmed publisher
    ..the expression kinetics and role of endogenous TLR4 ligands in the murine model of collagen-induced arthritis (CIA). Tenascin-C was upregulated in blood early in CIA, and correlated positively with the clinical score at day 56...
  61. van de Loo F, van den Berg W. Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators. Rheum Dis Clin North Am. 2002;28:127-49 pubmed
    ..gene transfer into the synovial arthritic joint with the emphasis on IL-1Ra, IL-4, and IL-10 effects on CIA in mice...
  62. Shovman O, Gilburd B, Chayat C, Amital H, Langevitz P, Watad A, et al. Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases. Clin Exp Rheumatol. 2018;36:121-126 pubmed
    ..patients with and without ANA-associated rheumatic diseases (AARDs) by two methods: chemiluminescent immunoassay (CIA) and an indirect immunofluorescence (IIF) assay based on immunoadsorption for DFS70...
  63. Crosby S, Benavidez G. From Nuremberg to Guantanamo Bay: Uses of Physicians in the War on Terror. Am J Public Health. 2017;:e1-e6 pubmed publisher
    ..played a critical role in designing, justifying, and carrying out the US state-sponsored torture program in the CIA "Black Sites" and US military detention centers, including Abu Ghraib, Bagram, and Guantanamo Bay, Cuba...
  64. Lin C, Hsu K, Chen C, Uang Y, Lin C. Differential changes in the pharmacokinetics of statins in collagen-induced arthritis rats. Biochem Pharmacol. 2017;142:216-228 pubmed publisher
    ..RA on the pharmacokinetics of statins of different disposition properties in rats with collagen-induced arthritis (CIA). The expression of metabolic enzymes and transporters in tissues of CIA rats were analyzed by RT-qPCR...