Gene Symbol: ASCL1
Description: achaete-scute family bHLH transcription factor 1
Alias: ASH1, HASH1, MASH1, bHLHa46, achaete-scute homolog 1, ASH-1, achaete scute protein, achaete-scute complex homolog 1, achaete-scute complex-like 1, class A basic helix-loop-helix protein 46
Species: human
Products:     ASCL1

Top Publications

  1. Jiang T, Collins B, Jin N, Watkins D, Brock M, Matsui W, et al. Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res. 2009;69:845-54 pubmed publisher
    The basic helix-loop-helix transcription factor achaete-scute complex homologue 1 (ASCL1) is essential for the development of normal lung neuroendocrine cells as well as other endocrine and neural tissues...
  2. Borges M, Linnoila R, van de Velde H, Chen H, Nelkin B, Mabry M, et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature. 1997;386:852-5 pubmed
    ..We show here that human achaete-scute homologue-1 (hASH1) is selectively expressed in normal fetal pulmonary neuroendocrine cells, as well as in the diverse range of lung ..
  3. Persson P, Jogi A, Grynfeld A, Pahlman S, Axelson H. HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. Biochem Biophys Res Commun. 2000;274:22-31 pubmed
    ..In conclusion, E2-2 forms a functional complex with HASH-1, and might therefore be involved in the development of specific parts of the central and peripheral nervous systems. ..
  4. Maxon M, Herskowitz I. Ash1p is a site-specific DNA-binding protein that actively represses transcription. Proc Natl Acad Sci U S A. 2001;98:1495-500 pubmed
    b>ASH1 encodes a protein that is localized specifically to the daughter cell nucleus, where it has been proposed to repress transcription of the HO gene...
  5. Wang X, Dakir E, Naizhen X, Jensen Taubman S, DeMayo F, Linnoila R. Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium. Lab Invest. 2007;87:527-39 pubmed
    ..Constitutive expression of human ASH-1 (hASH1) in mouse lung results in hyperplasia and remodeling that mimics bronchiolization of alveoli (BOA), a potentially ..
  6. Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, et al. Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res. 2008;68:1647-55 pubmed publisher
    The proneural basic-helix-loop-helix protein achaete-scute homologue 1 (ASH1) is expressed in a very limited spectrum of normal and cancerous cells in a lineage-specific manner, including normal pulmonary neuroendocrine cells and lung ..
  7. Johansson T, Lejonklou M, Ekeblad S, Stalberg P, Skogseid B. Lack of nuclear expression of hairy and enhancer of split-1 (HES1) in pancreatic endocrine tumors. Horm Metab Res. 2008;40:354-9 pubmed publisher
    ..We investigated the expression of NOTCH1, HES1, HEY1 and ASCL1 in pancreatic endocrine tumors and compared the data to tumor phenotype including hormone production, heredity, ..
  8. Miki M, Ball D, Linnoila R. Insights into the achaete-scute homolog-1 gene (hASH1) in normal and neoplastic human lung. Lung Cancer. 2012;75:58-65 pubmed publisher
    ..We examined human ASH1 (hASH1) expression across a comprehensive panel of human lung cancer cell lines, primary human lung tumors and normal ..
  9. Zhang L, Li X, Shen Y, Lin X, Wu M. Transdifferentiation effects and related mechanisms of nerve growth factor and internal limiting membrane on Müller cells. Exp Eye Res. 2019;180:146-154 pubmed publisher
    ..The expression of Achaete-scute homolog 1 (Ascl1, also called MASH1) (a neurodevelopmental gene) and endogenous NGF (closely related to neurogenesis) was also promoted by exogenous ..

More Information

Publications134 found, 100 shown here

  1. Gupta S, Sosa C, Kosari F, Folpe A, Bhinge K, Yang L, et al. A comparison of adult rhabdomyosarcoma and high grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma. Hum Pathol. 2019;: pubmed publisher
    ..were analyzed by immunohistochemistry for desmin, MyoD1, myogenin, chromogranin, synaptophysin, CD56, TTF1 and ASCL1 and RNAseq was performed on four cases of bladder rhabdomyosarcoma (two rhabdomyosarcomas and two sarcomatoid-..
  2. Akan I, Love D, Harwood K, Bond M, Hanover J. Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation. J Biol Chem. 2016;291:9906-19 pubmed publisher
    ..We found that trithorax (TRX), absent small or homeotic discs 1 (ASH1), and Compass member SET1 histone methyltransferases were O-GlcNAc-modified in oga(del.1) mutants. The oga(del...
  3. Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, et al. PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature. 2013;499:223-7 pubmed publisher
    ..falciparum variant-silencing SET gene (here termed PfSETvs), which encodes an orthologue of Drosophila melanogaster ASH1 and controls histone H3 lysine 36 trimethylation (H3K36me3) on var genes, results in the transcription of virtually ..
  4. Moraga A, Pradillo J, García Culebras A, Palma Tortosa S, Ballesteros I, Hernández Jiménez M, et al. Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia. J Neuroinflammation. 2015;12:87 pubmed publisher
    ..fibrillary acidic protein (GFAP)(+) cells) and type-C cells (prominin-1(+)/EGFR(+)/nestin(-)/Mash1(+) cells), and not affecting apoptosis, 1 day after stroke...
  5. Bai G, Cheung I, Shulha H, Coelho J, Li P, Dong X, et al. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet. 2015;24:1441-56 pubmed publisher
    ..binding of nuclear proteins to the methylated region and altered expression of HES4 and HES4 targeted genes MASH1 and P21 involved in striatal development...
  6. Ning Y, Huang J, Kalionis B, Bian Q, Dong J, Wu J, et al. Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5. Stem Cells Int. 2015;2015:672312 pubmed publisher
    ..Western blotting analysis revealed the protein levels of neuron-specific marker tubulin-βIII (TuJ1) and Mash1 were increased whilst the astrocyte-specific marker glial fibrillary acidic protein (GFAP) decreased...
  7. Desai M, Han G, Ross M. Programmed hyperphagia in offspring of obese dams: Altered expression of hypothalamic nutrient sensors, neurogenic factors and epigenetic modulators. Appetite. 2016;99:193-199 pubmed publisher
    ..pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC)...
  8. Wang J, Lu Z, Fu X, Zhang D, Yu L, Li N, et al. Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone. Transl Stroke Res. 2017;: pubmed publisher
    ..DCX), polysialylated - neuronal cell adhesion molecule (PSA-NCAM), and mammalian achaete-scute homolog 1 (Mash1)...
  9. Verlaat W, Snoek B, Heideman D, Wilting S, Snijders P, Novianti P, et al. Identification and Validation of a 3-Gene Methylation Classifier for HPV-Based Cervical Screening on Self-Samples. Clin Cancer Res. 2018;24:3456-3464 pubmed publisher
    ..of these markers in large series of lavage and brush self-samples yielded a 3-gene methylation classifier (ASCL1, LHX8, and ST6GALNAC5)...
  10. Farinetti A, Tomasi S, Foglio B, Ferraris A, Ponti G, Gotti S, et al. Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats. Neuroscience. 2015;286:162-70 pubmed publisher
    ..of cell proliferation phosphorylated form of Histone H3 (PHH3), or the marker of highly dividing SVZ progenitors Mash1, indicated the effect of T/E2 is mostly restricted to SVZ proliferating progenitors...
  11. Hardwick L, Philpott A. N-terminal phosphorylation of xHes1 controls inhibition of primary neurogenesis in Xenopus. Biochem Biophys Res Commun. 2019;509:557-563 pubmed publisher
    ..For example, neuronal differentiation is promoted by class II bHLH proneural proteins such as Ngn2 and Ascl1, while class VI Hes proteins act to restrain differentiation and promote progenitor maintenance...
  12. von Hardenberg J, Hartmann S, Nitschke K, Worst T, Ting S, Reis H, et al. Programmed Death Ligand 1 (PD-L1) Status and Tumor-Infiltrating Lymphocytes in Hot Spots of Primary and Liver Metastases in Prostate Cancer With Neuroendocrine Differentiation. Clin Genitourin Cancer. 2019;17:145-153.e5 pubmed publisher
    ..evaluation for additional real-time reverse transcription-quantitative PCR analysis (PD-L1, CGA, CD56, SYN, GRP, ASCL1, and DLK1). PD-L1 immunohistochemistry expression in NEPCA was observed by assay E1L3N in 5 (20...
  13. Iida Y, Masuda S, Nakanishi Y, Shimizu T, Nishimaki H, Takahashi M, et al. Clinicopathological characteristics of thyroid transcription factor 1-negative small cell lung cancers. Hum Pathol. 2018;79:127-134 pubmed publisher
    ..markers (synaptophysin, chromogranin A, and CD56), neuroendocrine cell-specific transcription factors (ASCL1, BRN2), a proliferation marker (Ki-67 labeling index), and an oncogene (NF1B)...
  14. Udhane S, Pandey A, Hofer G, Mullis P, Flück C. Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis. Sci Rep. 2015;5:10132 pubmed publisher
    ..starved H295R cells revealed fourteen differentially expressed genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in ..
  15. Gupta M, De Jesus D, Kahraman S, Valdez I, Shamsi F, Yi L, et al. Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Mol Metab. 2018;18:153-163 pubmed publisher
    ..of the iPSCs revealed that cells lacking IR showed enhanced expression of neuronal lineage markers (Pax6, Tubb3, Ascl1 and Oligo2) while exhibiting a decrease in adipocyte (Fas, Acc, Pparγ, Fabp4, C/ebpα, and Fsp27) and pancreatic ..
  16. Lin M, Su K, Su T, Chang C, Lin J, Lee Y, et al. Clinicopathological and genomic comparisons between different histologic components in combined small cell lung cancer and non-small cell lung cancer. Lung Cancer. 2018;125:282-290 pubmed publisher
    ..factor-1, p40, synaptophysin, chromogranin A, p53, retinoblastoma protein (Rb), and achaete-scute homolog 1 (ASCL1) via immunohistochemistry, and were macroscopically dissected for mutational analysis using next-generation ..
  17. Liu J, Bain L. Arsenic inhibits hedgehog signaling during P19 cell differentiation. Toxicol Appl Pharmacol. 2014;281:243-53 pubmed publisher
    ..2- to 3-fold, the Gli2 transcription factor, which was decreased 2- to 3-fold, and its downstream target gene Ascl1, which was decreased 5-fold. GLI2 protein levels and transcriptional activity were also reduced...
  18. Khalfallah O, Jarjat M, Davidovic L, Nottet N, Cestèle S, Mantegazza M, et al. Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis. Stem Cells. 2017;35:374-385 pubmed publisher
    ..Repressing FMRP in ESCs increased the expression of amyloid precursor protein (APP) and Ascl1. When inducing neuronal differentiation, βIII-tubulin, p27kip1 , NeuN, and NeuroD1 were upregulated, ..
  19. Radonjić N, Ortega J, Memi F, Dionne K, Jakovcevski I, Zecevic N. The complexity of the calretinin-expressing progenitors in the human cerebral cortex. Front Neuroanat. 2014;8:82 pubmed publisher
    ..First, we studied the expression of Gsx2 and its downstream effectors, Ascl1 and Sp8 in the cortical regions of the fetal human forebrain at midgestation...
  20. Pathak N, Pathak V, Lynch A, Irwin N, Gault V, Flatt P. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Mol Cell Endocrinol. 2015;412:95-103 pubmed publisher
    ..Furthermore, Oxm analogues up-regulated hippocampal mRNA expression of MASH1, Synaptophysin, SIRT1, GLUT4 and IRS1, and down-regulated expression of LDL-R and GSK3β...
  21. Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick J. Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy. Hum Gene Ther Methods. 2015;26:107-22 pubmed publisher reprogramming to dopaminergic neurons, we generated a Rosa26 knock-in mouse line conditionally overexpressing Mash1, Lmx1a, and Nurr1...
  22. Hardwick L, Philpott A. Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins. Neural Dev. 2015;10:15 pubmed publisher
    ..previously demonstrated that multi-site phosphorylation of two members of the proneural protein family, Ngn2 and Ascl1, limits their ability to drive neuronal differentiation when cyclin-dependent kinase levels are high, as would be ..
  23. Carter T, Kay D, Browne M, Liu A, Romitti P, Kuehn D, et al. Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation. J Hum Genet. 2012;57:485-93 pubmed publisher group and we tested for associations between HSCR and common variants in RET and candidate genes (ASCL1, homeobox B5 (HOXB5), L1 cell adhesion molecule (L1CAM), paired-like homeobox 2b (PHOX2B), PROK1 and PROKR1) ..
  24. Zhang S, Li M, Ji H, Fang Z. Landscape of transcriptional deregulation in lung cancer. BMC Genomics. 2018;19:435 pubmed publisher
    ..The proneural factor, ASCL1, was specifically up-regulated in SCLC which is known to have a neuroendocrine phenotype...
  25. Park E, Noh H, Park S. Identification of an Enhancer Critical for the ephirn-A5 Gene Expression in the Posterior Region of the Mesencephalon. Mol Cells. 2017;40:426-433 pubmed publisher
    ..mobility shift assay and luciferase-based transactivation assay revealed that the transcription factor Ascl1 bound the bHLH consensus binding site in the mesencephalon-specific ephrin-A5 enhancer in vitro...
  26. Smith K, Maragnoli M, Phull P, Tran K, Choubey L, Vaccarino F. Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PLoS ONE. 2014;9:e103696 pubmed publisher
    ..specification of GABAergic cells in the ganglionic eminence (GE) as assessed by in situ hybridization for Dlx2, Mash1 and Nkx2...
  27. Jansen R, Niessing D. Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes--an overview. Curr Protein Pept Sci. 2012;13:284-93 pubmed
    ..The first example is She2p/She3p-dependent localization of ASH1 mRNA in budding yeast...
  28. Sun J, Rockowitz S, Xie Q, Ashery Padan R, Zheng D, Cvekl A. Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. Nucleic Acids Res. 2015;43:6827-46 pubmed publisher
    ..Pax6 directly regulates cortical neurogenesis through activation (e.g. Dmrta1 and Ngn2) and repression (e.g. Ascl1, Fezf2, and Gsx2) of transcription factors...
  29. Legrand M, Lam S, Anselme I, Gloaguen C, Ibanez C, Eriksson P, et al. Exposure to depleted uranium during development affects neuronal differentiation in the hippocampal dentate gyrus and induces depressive-like behavior in offspring. Neurotoxicology. 2016;57:153-162 pubmed publisher GD 13 embryos from DU exposed dams and decreased expression of Notch1 and increased expression of Mash1 in the hippocampal and dentate neuroepithelia of GD 18 fetuses from DU exposed dams...
  30. Ware M, Hamdi Rozé H, Dupé V. Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus. Front Neuroanat. 2014;8:140 pubmed publisher
    ..Further analysis in the chick and mouse hypothalamus confirms the expression of Notch components and Ascl1 before the appearance of the first differentiated neurons...
  31. Lee B, Yoon J, Tri Lam D, Yoon J, Baek K, Jeong Y. Identification of a conserved cis-regulatory element controlling mid-diencephalic expression of mouse Six3. Genesis. 2017;55: pubmed publisher
    ..We also showed that normal Six3 transcription in the ventral midbrain and pretectum is dependent on Ascl1, a basic helix-loop-helix proneural factor...
  32. Rodríguez Traver E, Solís O, Díaz Guerra E, Ortiz Ã, Vergaño Vera E, Méndez Gómez H, et al. Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells. Neurotox Res. 2016;30:14-31 pubmed publisher
    ..Transduction of Nurr1 alone or in combination with other transcription factors such as Foxa2, Ngn2, Ascl1, and Pitx3, induces the generation of DA neurons, which upon transplantation have the capacity to survive and ..
  33. Yazawa T. Recent advances in histogenesis research of lung neuroendocrine cancers: Evidence obtained from functional analyses of primitive neural/neuroendocrine cell-specific transcription factors. Pathol Int. 2015;65:277-85 pubmed publisher
    ..In this review, the functions of ASCL1, NeuroD1, REST, TTF1, and class III/IV POU, that are specifically and highly expressed in lung NECs, are ..
  34. Kaylan K, Gentile S, Milling L, Bhinge K, Kosari F, Underhill G. Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays. Integr Biol (Camb). 2016;8:1221-1231 pubmed
    ..We further determined that expression of the neuroendocrine transcription factor ASCL1, which has been previously associated with poor patient outcome when co-expressed with the RET oncogene, altered ..
  35. Stubbusch J, Narasimhan P, Hennchen M, Huber K, Unsicker K, Ernsberger U, et al. Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015;400:210-23 pubmed publisher
    ..The postnatal death of chromaffin cells is preceded by the loss of Ascl1, mir-375 and Pnmt and an increase in the markers Ret and NF-M, which suggests that Dicer1 is required for the ..
  36. Costa Urrutia P, Abud C, Franco Trecu V, Colistro V, Rodríguez Arellano M, Granados J, et al. Genetic susceptibility to pre diabetes mellitus and related association with obesity and physical fitness components in Mexican-Mestizos. Prim Care Diabetes. 2018;12:416-424 pubmed publisher
    ..The A allele of ASCL1 rs9997745 conferred increased risk (OR=3.39, p=0.001) of pre-DM which is modulated by BMI...
  37. Weese Mayer D, Berry Kravis E, Zhou L, Maher B, Curran M, Silvestri J, et al. Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. Pediatr Res. 2004;56:391-5 pubmed
    ..We therefore studied genes pertinent to early embryologic development of the ANS, including MASH1, BMP2, PHOX2a, PHOX2b, RET, ECE1, EDN1, TLX3, and EN1 in 92 probands with SIDS and 92 gender- and ethnicity-..
  38. Westerman B, Neijenhuis S, Poutsma A, Steenbergen R, Breuer R, Egging M, et al. Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features. Clin Cancer Res. 2002;8:1082-6 pubmed
    The Human Achaete-Scute homologue 1 (HASH1, ASCL1), a lineage-specific basic helix-loop-helix member of the achaete-scute family, is essential for the generation of pulmonary neuroendocrine (NE) cells during lung development...
  39. Shida T, Furuya M, Nikaido T, Kishimoto T, Koda K, Oda K, et al. Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas. Clin Cancer Res. 2005;11:450-8 pubmed
    ..In this study, distinctive up-regulation of human achaete-scute homologue 1 (hASH1) in gastrointestinal NECs was clarified...
  40. Fujino K, Motooka Y, Hassan W, Ali Abdalla M, Sato Y, Kudoh S, et al. Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer. Am J Pathol. 2015;185:3164-77 pubmed publisher
    ..INSM1 gene expression is specific for small-cell lung cancer (SCLC), along with achaete-scute homolog-like 1 (ASCL1) and several NE molecules, such as chromogranin A, synaptophysin, and neural cell adhesion molecule 1...
  41. Wright L, Pinilla I, Saha J, Clermont J, Lien J, Borys K, et al. VSX2 and ASCL1 Are Indicators of Neurogenic Competence in Human Retinal Progenitor Cultures. PLoS ONE. 2015;10:e0135830 pubmed publisher
    ..In contrast, the proneural transcription factor Acheate scute-like 1 (ASCL1) is expressed transiently in a subset of RPCs, but is required for the production of most retinal neurons...
  42. Min Z, Lin H, Zhu X, Gao L, Khand A, Tao Q. Ascl1 represses the mesendoderm induction in Xenopus. Acta Biochim Biophys Sin (Shanghai). 2016;48:1006-1015 pubmed
    b>Ascl1 is a multi-functional regulator of neural development in invertebrates and vertebrates. Ectopic expression of Ascl1 can generate functional neurons from non-neural somatic cells...
  43. Marsters C, Rosin J, Thornton H, Aslanpour S, Klenin N, Wilkinson G, et al. Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1. Neural Dev. 2016;11:20 pubmed
    ..We further employed Ascl1 and Neurog2 mutant mice to probe the influence of these proneual genes on developing embryonic gliogenic ..
  44. Kasim M, Heß V, Scholz H, Persson P, Fähling M. Achaete-Scute Homolog 1 Expression Controls Cellular Differentiation of Neuroblastoma. Front Mol Neurosci. 2016;9:156 pubmed publisher
    ..Human achaete-scute homolog 1 (hASH1) is a proneural basic helix-loop-helix transcription factor essential for neurogenesis and is often upregulated in ..
  45. Liu Y, Tsai J, Chen J, Yang W, Chang P, Cheng P, et al. Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Sci Rep. 2017;7:42895 pubmed publisher
    ..Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important roles in the developing telencephalon, whether Ascl1 regulates tangential migration remains ..
  46. Dennis D, Wilkinson G, Li S, Dixit R, Adnani L, Balakrishnan A, et al. Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proc Natl Acad Sci U S A. 2017;114:E4934-E4943 pubmed publisher
    ..The proneural genes Neurog2 and Ascl1 cooperate in progenitors to control the temporal switch from neurogenesis to gliogenesis...
  47. Guillemot F, Hassan B. Beyond proneural: emerging functions and regulations of proneural proteins. Curr Opin Neurobiol. 2017;42:93-101 pubmed publisher
    Proneural proteins, which include Ascl1, Atoh1 and Neurogenins épinière in vertebrates and Achaete-Scute proteins and Atonal in Drosophila, are expressed in the developing nervous system throughout the animal kingdom and have an ..
  48. Edelmann F, Schlundt A, Heym R, Jenner A, Niedner Boblenz A, Syed M, et al. Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex. Nat Struct Mol Biol. 2017;24:152-161 pubmed publisher
    ..Using X-ray crystallography and complementary techniques, we carried out a detailed assessment of an LE of the ASH1 mRNA from yeast, its complex with its shuttling RNA-binding protein She2p, and its highly specific, cytoplasmic ..
  49. Rivetti di Val Cervo P, Romanov R, Spigolon G, Masini D, Martín Montañez E, Toledo E, et al. Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Nat Biotechnol. 2017;35:444-452 pubmed publisher
    ..Using three transcription factors, NEUROD1, ASCL1 and LMX1A, and the microRNA miR218, collectively designated NeAL218, we reprogram human astrocytes in vitro, and ..
  50. Chen J, Wang Q, Zhou J, Deng W, Yu Q, Cao X, et al. Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells. Nanoscale. 2017;9:10820-10831 pubmed publisher
    ..The optimal combination of factors (Ascl1 and Brn2) was selected from seven different combinations out of Ascl1, Brn2 and Sox2 according to the expression ..
  51. Lisi V, Singh B, Giroux M, Guzman E, Painter M, Cheng Y, et al. Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. Cell Rep. 2017;20:1136-1147 pubmed publisher
    ..RNA sequencing of dorsal root ganglia (DRG) showed a CAST/Ei-specific upregulation of Ascl1 after injury. Ascl1 overexpression in DRG neurons of C57BL/6 mice enhanced their neurite outgrowth...
  52. Liu J, Lu W, Ye F, Cheng X, Hong D, Hu Y, et al. Hes1/Hes5 gene inhibits differentiation via down-regulating Hash1 and promotes proliferation in cervical carcinoma cells. Int J Gynecol Cancer. 2010;20:1109-16 pubmed
    ..Knockdown of Hes1 and Hes5 would up-regulate the downstream gene Hash1, but not the upstream gene Notch1 in the Notch-Hes-Hash pathway...
  53. Yang S, Alvarez D, Schinder A. Reliable Genetic Labeling of Adult-Born Dentate Granule Cells Using Ascl1 CreERT2 and Glast CreERT2 Murine Lines. J Neurosci. 2015;35:15379-90 pubmed publisher
    ..b>Ascl1(CreERT2);CAG(floxStopTom) and Glast(CreERT2);CAG(floxStopTom) mice resulted in indelible expression of Tom in ..
  54. Wang X, Ma S, Meng N, Yao N, Zhang K, Li Q, et al. Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs. Mol Cells. 2016;39:418-25 pubmed publisher
    ..markers (Nestin, ?III-tubulin and NSE), as well as pro-neural transcription factors Neurogenin (Ngn)1, Ngn2 and Mash1. Taken together, RES exerts a dosage-dependent effect on the self-renewal and neural differentiation of hUC-MSCs ..
  55. Browne A, Charmsaz S, Varešlija D, Fagan A, Cosgrove N, Cocchiglia S, et al. Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer. Oncogene. 2018;37:2008-2021 pubmed publisher
    ..TF partner, important in the regulation of a cadre of four SRC-1 transcription targets, NFIA, SMAD2, E2F7 and ASCL1. Extended network analysis identified a downstream 79 gene network, the clinical relevance of which was ..
  56. Obiri S, Ansa Asare O, Mohammed S, Darko H, Dartey A. Exposure to toxicants in soil and bottom ash deposits in Agbogbloshie, Ghana: human health risk assessment. Environ Monit Assess. 2016;188:583 pubmed
    ..Concentrations of Pb, Cd, Cr, Cu, As, Sn, Zn and Co in bottom ash samples from location ASH1 are 5388 ± 0.02 mg/kg (Pb), 2.39 ± 0.01 mg/kg (Cd), 42 ± 0.05 mg/kg (Cr), 7940 ± 0...
  57. Yu Q, Chen J, Deng W, Cao X, Wang Y, Zhou J, et al. Direct reprogramming of mouse fibroblasts into neural cells via Porphyra yezoensis polysaccharide based high efficient gene co-delivery. J Nanobiotechnology. 2017;15:82 pubmed publisher
    ..yezoensis polysaccharide (Ed-PYP) served as a gene carrier and a group of plasmids that encode Ascl1, Brn4, and Tcf3 (pABT) self-assembled into nanoparticles...
  58. Chouchane M, Costa M. Instructing neuronal identity during CNS development and astroglial-lineage reprogramming: Roles of NEUROG2 and ASCL1. Brain Res. 2019;1705:66-74 pubmed publisher
    ..this review, we discuss the contribution of the proneural genes Neurogenin2 (Neurog2) and Achaete-scute homolog 1 (Ascl1) for the specification of neuronal phenotypes in the developing neocortex, cerebellum and retina...
  59. Black B, Ligon K, Zhang Y, Olson E. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996;271:26659-63 pubmed
    ..Here, we show that the neurogenic bHLH protein MASH1 interacts with members of the MEF2 family and that this interaction, mediated by the DNA binding and dimerization ..
  60. Mhawech P, Berczy M, Assaly M, Herrmann F, Bouzourene H, Allal A, et al. Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly differentiated tumors arising in the sinonasal tract. Am J Clin Pathol. 2004;122:100-5 pubmed
    ..The human achaete-scute homologue (hASH1) gene is critical in olfactory neuronal differentiation and is expressed in immature olfactory cells; therefore, ..
  61. Gorris R, Fischer J, Erwes K, Kesavan J, Peterson D, Alexander M, et al. Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia. 2015;63:2152-67 pubmed publisher
    ..glia (RG)-like neural precursor cells (RGL-NPCs) expressing typical neural stem cell markers such as nestin, ASCL1, SOX2, and PAX6 as well as RG markers BLBP, GLAST, vimentin, and GFAP...
  62. Brooker S, Gobeske K, Chen J, Peng C, Kessler J. Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment. Mol Psychiatry. 2017;22:910-919 pubmed publisher
    ..Similarly, conditional genetic deletion of the type II BMP receptor in Ascl1-expressing cells promoted neurogenesis and reduced anxiety- and depression-like behaviors, suggesting that neural ..
  63. Arai M, Zhan B, Maruyama A, Matsui Harada A, Horinouchi K, Komai S. Enriched environment and Mash1 transfection affect neural stem cell differentiation after transplantation into the adult somatosensory cortex. J Neurol Sci. 2017;373:73-80 pubmed publisher
    ..the effect of additive rehabilitative therapy with enriched environment (EE) and of achaete-scute homolog 1 (Mash1) and neurogenin2 (Ngn2) transduction on the fate of NSCs (P28-P35) transplanted into the primary somatosensory ..
  64. Chouchane M, Melo de Farias A, Moura D, Hilscher M, Schroeder T, Leão R, et al. Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes. Stem Cell Reports. 2017;9:162-176 pubmed publisher
    ..isolated from the postnatal brain reprogrammed either with Neurogenin-2 (Neurog2) or Achaete scute homolog-1 (Ascl1)...
  65. Sriuranpong V, Borges M, Strock C, Nakakura E, Watkins D, Blaumueller C, et al. Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol. 2002;22:3129-39 pubmed rapid degradation of the basic helix-loop-helix (bHLH) transcription factor human achaete-scute homolog 1 (hASH1)...
  66. Poirier J, Dobromilskaya I, Moriarty W, Peacock C, Hann C, Rudin C. Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer. J Natl Cancer Inst. 2013;105:1059-65 pubmed publisher
    ..revealed that permissive lines are typified by lower expression of the early neurogenic transcription factor ASCL1 and, conversely, by higher expression of the late neurogenic transcription factor NEUROD1...
  67. Isogai E, Okumura K, Saito M, Yoshizawa Y, Itoh K, Tando S, et al. Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice. Exp Anim. 2015;64:407-14 pubmed publisher
    We previously reported that LMO3 and HEN2 act as oncogenes in neuroblastoma development through up-regulating MASH1 transcription by interfering with HES1. To confirm these results in vivo, we generated transgenic mice of these genes...
  68. Zhang J, Weng Z, Tsang K, Tsang L, Chan H, Jiang X. MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. PLoS ONE. 2016;11:e0148062 pubmed publisher
    ..expression of key transcription factors involved in sympathetic neuron differentiation, including Phox2a, Phox2b, Mash1, Hand2 and Gata3...
  69. PACKARD A, Lin B, Schwob J. Sox2 and Pax6 Play Counteracting Roles in Regulating Neurogenesis within the Murine Olfactory Epithelium. PLoS ONE. 2016;11:e0155167 pubmed publisher
    ..of OSNs driven by Sox2 is due to the expansion of neuronal progenitors, since proliferation and the numbers of Ascl1, Neurog1, and NeuroD1-expressing GBCs are increased...
  70. De Gregorio R, Pulcrano S, De Sanctis C, Volpicelli F, Guatteo E, von Oerthel L, et al. miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. Stem Cell Reports. 2018;10:1237-1250 pubmed publisher
    ..When combined with transcription factors ASCL1 and NURR1, miR-34b/c doubled the yield of transdifferentiated fibroblasts into dopaminergic neurons...
  71. Schmähling S, Meiler A, Lee Y, Mohammed A, Finkl K, Tauscher K, et al. Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC. Development. 2018;145: pubmed publisher
    The Drosophila Ash1 protein is a trithorax-group (trxG) regulator that antagonizes Polycomb repression at HOX genes...
  72. Shida T, Furuya M, Kishimoto T, Nikaido T, Tanizawa T, Koda K, et al. The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors. Mod Pathol. 2008;21:1363-70 pubmed publisher
    ..In the present study, we assessed the expression of transcription factors (NeuroD and mASH1) essential for the normal fetal neuronal development in 33 gastroenteropancreatic neuroendocrine tumor patients (..
  73. Vadodaria K, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, et al. Generation of functional human serotonergic neurons from fibroblasts. Mol Psychiatry. 2016;21:49-61 pubmed publisher
    ..We found that overexpressing the transcription factors NKX2.2, FEV, GATA2 and LMX1B in combination with ASCL1 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts...
  74. Delorme Axford E, Abernathy E, Lennemann N, Bernard A, Ariosa A, Coyne C, et al. The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy. 2018;14:898-912 pubmed publisher
    ..Xrn1 expression is regulated by the yeast transcription factor Ash1 in rich conditions...
  75. de Pontual L, Nepote V, Attie Bitach T, Al Halabiah H, Trang H, Elghouzzi V, et al. Noradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation syndrome (Ondine's curse). Hum Mol Genet. 2003;12:3173-80 pubmed
  76. Yang Y, Ting Y, Liang K, Lo K. The Roles of Puf6 and Loc1 in 60S Biogenesis Are Interdependent, and Both Are Required for Efficient Accommodation of Rpl43. J Biol Chem. 2016;291:19312-23 pubmed publisher
    ..Puf6 and Loc1 are localized predominantly in the nucleolus. They bind ASH1 mRNA, repress its translation, and facilitate the transport to the daughter cells...
  77. Ito T, Kudoh S, Ichimura T, Fujino K, Hassan W, Udaka N. Small cell lung cancer, an epithelial to mesenchymal transition (EMT)-like cancer: significance of inactive Notch signaling and expression of achaete-scute complex homologue 1. Hum Cell. 2017;30:1-10 pubmed publisher
    ..On the other hand, achaete-scute complex homologue 1 (ASCL1), negatively regulated by Notch signaling, is a lineage-specific gene of SCLC, and functions to promote ..
  78. Ide M, Yamada K, Toyota T, Iwayama Y, Ishitsuka Y, Minabe Y, et al. Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease. Hum Genet. 2005;117:520-7 pubmed
    ..b>ASCL1 was considered as a candidate interacting partner of PHOX2B, as ASCL1 is a transcription factor that co-regulates ..
  79. Passos Gregorio S, Gattaz W, Tavares H, Kieling C, Timm S, Wang A, et al. Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. Schizophr Res. 2006;88:275-82 pubmed
    ..we investigated the link of non-synonymous variants of five genes of the Notch pathway (NOTCH2, NOTCH3, JAGGED2, ASCL1 and NUMBL) to schizophrenia in a group of 200 Brazilian patients and 200-paired controls...
  80. Ralston J, Chiriboga L, Nonaka D. MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma. Mod Pathol. 2008;21:1357-62 pubmed publisher
    ..Achaete-scute complex-like 1 (MASH1, ASCL1) is important in the development of the brain and the diffuse neuroendocrine system including pulmonary ..
  81. McGaughey D, McCallion A. Efficient discovery of ASCL1 regulatory sequences through transgene pooling. Genomics. 2010;95:363-9 pubmed publisher
    ..We selected a 64kb interval encompassing the human ASCL1 locus as our model interval and report the analysis of 9 highly conserved putative enhancers therein...
  82. Przybylski G, Dittmann K, Grabarczyk P, Dölken G, Gesk S, Harder L, et al. Molecular characterization of a novel chromosomal translocation t(12;14)(q23;q11.2) in T-lymphoblastic lymphoma between the T-cell receptor delta-deleting elements (TRDREC and TRAJ61) and the hypothetical gene C12orf42. Eur J Haematol. 2010;85:452-6 pubmed publisher
  83. Memic F, Knoflach V, Sadler R, Tegerstedt G, Sundström E, Guillemot F, et al. Ascl1 Is Required for the Development of Specific Neuronal Subtypes in the Enteric Nervous System. J Neurosci. 2016;36:4339-50 pubmed publisher
    ..Here we redefine the role of Ascl1 (Mash1), one of the few regulatory transcription factors described during ENS development...
  84. Zhang Q, Zhang Y, Wang C, Xu Z, Liang Q, An L, et al. The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. Cell Rep. 2016;16:1431-1444 pubmed publisher
    ..ChIP qPCR provides evidence that Ascl1 directly binds the Sp9 promoter...
  85. Wapinski O, Lee Q, Chen A, Li R, Corces M, Ang C, et al. Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons. Cell Rep. 2017;20:3236-3247 pubmed publisher
    ..Here, we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout conversion of fibroblasts into induced neuronal (iN) cells...
  86. Johansson T, Westin G, Skogseid B. Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours. BMC Cancer. 2009;9:321 pubmed publisher
    b>ASCL1 role in pancreatic endocrine tumourigenesis has not been established. Recently it was suggested that ASCL1 negatively controls expression of the Wnt signalling antagonist DKK1...
  87. Phi J, Kim J, Eun K, Wang K, Park K, Choi S, et al. Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas. J Neurosurg Pediatr. 2010;5:608-14 pubmed publisher
    ..The authors compared the expression of specific genes involved in neuroglial differentiation in supratentorial PNETs and medulloblastomas to define the distinct characters of these tumors...
  88. Zhao H, Zhu L, Jin Y, Ji H, Yan X, Zhu X. miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells. Acta Biochim Biophys Sin (Shanghai). 2012;44:177-82 pubmed publisher
    ..cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1)...
  89. Wang X, Jensen Taubman S, Keefe K, Yang D, Linnoila R. Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase. PLoS ONE. 2012;7:e52832 pubmed publisher
    Lung cancer is the leading cause of cancer-related deaths in the world. Achaete-scute complex homolog-1 (Ascl1) is a member of the basic helix-loop-helix (bHLH) transcription factor family that has multiple functions in the normal and ..
  90. Somnay Y, Dull B, Eide J, Jaskula Sztul R, Chen H. Chrysin suppresses achaete-scute complex-like 1 and alters the neuroendocrine phenotype of carcinoids. Cancer Gene Ther. 2015;22:496-505 pubmed publisher
    ..Here we report chrysin's ability to modulate the achaete-scute complex-like 1 (ASCL1), a neuroendocrine-specific transcription factor highly implicated in the malignant phenotype of carcinoids and ..
  91. Kohli V, Nardini D, Ehrman L, Waclaw R. Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon. Dev Dyn. 2018;247:222-228 pubmed publisher
    ..cells are restricted to a subpopulation of Gsx2 positive cells on the basal side of the VZ and co-express Ascl1, but not the subventricular zone dLGE marker, Sp8...
  92. Jorstad N, Wilken M, Grimes W, Wohl S, VandenBosch L, Yoshimatsu T, et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature. 2017;548:103-107 pubmed publisher
    ..The proneural transcription factor Ascl1 is upregulated in MG after retinal damage in zebrafish and is necessary for regeneration...