ASC

Summary

Gene Symbol: ASC
Description: PYD and CARD domain containing
Alias: ASC, CARD5, TMS, TMS-1, TMS1, apoptosis-associated speck-like protein containing a CARD, caspase recruitment domain-containing protein 5, target of methylation-induced silencing 1
Species: human
Products:     ASC

Top Publications

  1. Hasegawa M, Imamura R, Kinoshita T, Matsumoto N, Masumoto J, Inohara N, et al. ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. J Biol Chem. 2005;280:15122-30 pubmed
    b>ASC is an adaptor molecule that mediates apoptotic and inflammatory signals from several Apaf-1-like molecules, including CARD12/Ipaf, cryopyrin/PYPAF1, PYPAF5, PYPAF7, and NALP1...
  2. McConnell B, Vertino P. Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. Cancer Res. 2000;60:6243-7 pubmed
    ..Recently, our laboratory has isolated a novel gene, TMS1, that is aberrantly methylated and silenced in a significant proportion of human breast cancers...
  3. Martinon F, Hofmann K, Tschopp J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol. 2001;11:R118-20 pubmed
  4. Stehlik C, Lee S, Dorfleutner A, Stassinopoulos A, Sagara J, Reed J. Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J Immunol. 2003;171:6154-63 pubmed
    Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)/target of methylation-induced silencing/PYCARD represents one of only two proteins encoded in the human genome that contains a caspase recruitment ..
  5. Stimson K, Vertino P. Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. J Biol Chem. 2002;277:4951-8 pubmed
    ..for endogenous targets of methylation-mediated gene silencing, we identified a novel CpG island-associated gene, TMS1, which is aberrantly methylated and silenced in response to the ectopic expression of DNA methyltransferase-1...
  6. Guan X, Sagara J, Yokoyama T, Koganehira Y, Oguchi M, Saida T, et al. ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma. Int J Cancer. 2003;107:202-8 pubmed
    ASC/TMS1 is an adaptor protein activating caspase-1 that stimulates processing of proIL-1beta and proIL-18. ASC was reported to be aberrantly methylated and silenced in human breast cancers...
  7. Yu J, Fernandes Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, et al. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell. 2007;28:214-27 pubmed
    ..Here, we demonstrate that PSTPIP1 requires the familial Mediterranean fever protein pyrin to assemble the ASC pyroptosome, a molecular platform that recruits and activates caspase-1...
  8. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10:417-26 pubmed
    ..The inflammasome comprises caspase-1, caspase-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs...
  9. Taxman D, Zhang J, Champagne C, Bergstralh D, Iocca H, Lich J, et al. Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J Immunol. 2006;177:4252-6 pubmed
    ..This work examines the role of apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), an adaptor molecule important for TLR-mediated caspase-1 activation...

More Information

Publications91

  1. Dowds T, Masumoto J, Chen F, Ogura Y, Inohara N, Nunez G. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun. 2003;302:575-80 pubmed
    ..We report here that co-expression of cryopyrin with its binding partner, ASC, induced both apoptosis and NF-kappaB activation...
  2. Yokoyama T, Sagara J, Guan X, Masumoto J, Takeoka M, Komiyama Y, et al. Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer. Cancer Lett. 2003;202:101-8 pubmed
    ASC/TMS1, a proapoptotic activator of procaspase-1, was reported to be aberrantly methylated in human breast cancer. We found that ASC was methylated in three of five human colon cancer cell lines lacking ASC protein expression...
  3. Ohtsuka T, Ryu H, Minamishima Y, Macip S, Sagara J, Nakayama K, et al. ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol. 2004;6:121-8 pubmed
    The apoptosis-associated speck-like protein (ASC) is an unusual adaptor protein that contains the Pyrin/PAAD death domain in addition to the CARD protein-protein interaction domain...
  4. Virmani A, Rathi A, Sugio K, Sathyanarayana U, Toyooka S, Kischel F, et al. Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer. Int J Cancer. 2003;106:198-204 pubmed
    b>TMS1 (target of methylation-induced silencing) is a CpG island-associated gene that functions in the regulation of apoptosis and encodes a caspase recruitment domain, a recently described motif found in apoptotic signaling molecules...
  5. Stehlik C, Fiorentino L, Dorfleutner A, Bruey J, Ariza E, Sagara J, et al. The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med. 2002;196:1605-15 pubmed
    Apoptosis-associated speck-like protein containing a Caspase recruitment domain (ASC) belongs to a large family of proteins that contain a Pyrin, AIM, ASC, and death domain-like (PAAD) domain (also known as PYRIN, DAPIN, Pyk)...
  6. Shiohara M, Taniguchi S, Masumoto J, Yasui K, Koike K, Komiyama A, et al. ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils. Biochem Biophys Res Commun. 2002;293:1314-8 pubmed
    b>ASC is an adaptor protein that is composed of two protein-protein interaction domains, a PYRIN domain (PYD), and a caspase-recruitment domain (CARD)...
  7. Das P, Ramachandran K, vanWert J, Ferdinand L, Gopisetty G, Reis I, et al. Methylation mediated silencing of TMS1/ASC gene in prostate cancer. Mol Cancer. 2006;5:28 pubmed
    ..b>TMS1 (Target of Methylation induced Silencing), also known as ASC (Apoptosis Speck like protein containing a CARD) is a ..
  8. Terasawa K, Sagae S, Toyota M, Tsukada K, Ogi K, Satoh A, et al. Epigenetic inactivation of TMS1/ASC in ovarian cancer. Clin Cancer Res. 2004;10:2000-6 pubmed
    ..Of the four proapoptotic genes studied, expression of TMS1/ASC was absent in six ovarian cancer cell lines...
  9. Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D, Wewers M. ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 2006;176:4979-86 pubmed
    ..Apoptosis-associated speck-like protein containing a CARD (ASC) is a PYRIN and CARD-containing molecule, important in the induction of apoptosis and caspase-1 activation...
  10. Yu J, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, et al. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ. 2006;13:236-49 pubmed
    ..Using a HEK293 cell-based reconstitution system that stably expresses ASC and procaspase-1 we demonstrated that neither cryopyrin nor pyrin or their corresponding disease-associated mutants ..
  11. Liepinsh E, Barbals R, Dahl E, Sharipo A, Staub E, Otting G. The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. J Mol Biol. 2003;332:1155-63 pubmed
    ..The three-dimensional structure of the PYRIN domain from human ASC was determined by NMR spectroscopy...
  12. Hornung V, Ablasser A, Charrel Dennis M, Bauernfeind F, Horvath G, Caffrey D, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8 pubmed publisher
    ..DNA, whereas the pyrin domain (but not that of the other PYHIN family members) associates with the adaptor molecule ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) to activate both ..
  13. Shi C, Shenderov K, Huang N, Kabat J, Abu Asab M, Fitzgerald K, et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol. 2012;13:255-63 pubmed publisher
    ..The induction of autophagy did not depend on the adaptor ASC or capase-1 but was dependent on the presence of the inflammasome sensor...
  14. Lu A, Magupalli V, Ruan J, Yin Q, Atianand M, Vos M, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014;156:1193-1206 pubmed publisher
    ..AIM2 and NLRP3 are representative sensor proteins in two major families of inflammasomes. The adaptor protein ASC bridges the sensor proteins and caspase-1 to form ternary inflammasome complexes, achieved through pyrin domain (..
  15. Mishra B, Moura Alves P, Sonawane A, Hacohen N, Griffiths G, Moita L, et al. Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cell Microbiol. 2010;12:1046-63 pubmed publisher
    ..Most importantly, NLRP3, ASC and caspase-1 form an infection-inducible inflammasome complex that is essential for IL-1beta secretion...
  16. Conway K, McConnell B, Bowring C, Donald C, Warren S, Vertino P. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res. 2000;60:6236-42 pubmed
    ..Here we report the isolation and characterization of TMS1 (target of methylation-induced silencing), a novel CpG island-associated gene that becomes hypermethylated and ..
  17. Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-25 pubmed
    ..Here, we report that NALP2 and NALP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not caspase-5), thereby forming an inflammasome with high ..
  18. Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1999;274:33835-8 pubmed
    ..We referred to this protein as ASC (apoptosis-associated speck-like protein containing a CARD). The ASC gene was mapped on chromosome 16p11.2-12...
  19. Wang L, Manji G, Grenier J, Al Garawi A, Merriam S, Lora J, et al. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem. 2002;277:29874-80 pubmed
    ..4, a locus that contains a cluster of genes encoding numerous PYPAF family members. Co-expression of PYPAF7 with ASC results in the recruitment of PYPAF7 to distinct cytoplasmic loci and a potent synergistic activation of NF-kappa B...
  20. Srinivasula S, Poyet J, Razmara M, Datta P, Zhang Z, Alnemri E. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem. 2002;277:21119-22 pubmed
    ..Here we show that the PYRIN-CARD protein ASC functions as a caspase-1-activating adaptor...
  21. Manji G, Wang L, Geddes B, Brown M, Merriam S, Al Garawi A, et al. PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. J Biol Chem. 2002;277:11570-5 pubmed
    ..To identify downstream signaling partners of PYPAF1, we performed a mammalian two-hybrid screen and identified ASC as a PYRIN-containing protein that interacts selectively with the PYRIN domain of PYPAF1...
  22. Richards N, Schaner P, Diaz A, Stuckey J, Shelden E, Wadhwa A, et al. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. J Biol Chem. 2001;276:39320-9 pubmed
    ..made from neutrophil cDNA, we isolated apoptotic speck protein containing a caspase recruitment domain (CARD) (ASC), a proapoptotic protein that induces the formation of large cytosolic "specks" in transfected cells...
  23. Moriya M, Taniguchi S, Wu P, Liepinsh E, Otting G, Sagara J. Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC. Biochemistry. 2005;44:575-83 pubmed
    Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein composed of two homophilic protein-protein interaction domains, a PYRIN domain (PYD) and a caspase recruitment domain...
  24. Ramani S, Neill F, Ferreira J, Treanor J, Frey S, Topham D, et al. B-Cell Responses to Intramuscular Administration of a Bivalent Virus-Like Particle Human Norovirus Vaccine. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..b>ASC responses peaked at day 7 after the first dose of vaccine and returned to nearly baseline levels by day 28...
  25. Coronado P, Fasero M. Colposcopy combined with dynamic spectral imaging. A prospective clinical study. Eur J Obstet Gynecol Reprod Biol. 2016;196:11-6 pubmed publisher
    ..Four hundred seventy-nine women referred for colposcopy after an abnormal Pap-smear (≥ASC-US) to the Low Genital Tract Unit of the San Carlos Clinical Hospital in Madrid, Spain during the years 2012-2014 ..
  26. Sweetman L, Ashcraft P, Bennett Firmin J. Quantitative Organic Acids in Urine by Two Dimensional Gas Chromatography-Time of Flight Mass Spectrometry (GCxGC-TOFMS). Methods Mol Biol. 2016;1378:183-97 pubmed publisher
    ..After drying the supernatant, the organic acids are derivatized to form volatile trimethylsilyl (TMS) derivatives for separation by capillary two dimensional Gas Chromatography (GCxGC) with temperature programming ..
  27. Zhang C, Wen P, Sun Y. Withdrawal of immunosuppression in liver transplantation and the mechanism of tolerance. Hepatobiliary Pancreat Dis Int. 2015;14:470-6 pubmed
    ..inflammasome through apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) in dendritic cells is associated with rejection after liver transplantation...
  28. Eslick E, Bailey D, Harris B, Kipritidis J, Stevens M, Li B, et al. Measurement of preoperative lobar lung function with computed tomography ventilation imaging: progress towards rapid stratification of lung cancer lobectomy patients with abnormal lung function. Eur J Cardiothorac Surg. 2016;49:1075-82 pubmed publisher
    ..by (i) positron emission tomography ventilation (PET-V) imaging and (ii) the standard anatomical segment counting (ASC) method...
  29. Wu Y, Liu S, Liao R. Prediction accuracy of intraocular lens power calculation methods after laser refractive surgery. BMC Ophthalmol. 2017;17:44 pubmed publisher
    ..coherence interferometry (IOL-Master) and applanation ultrasound (AL-3000) assisted with corneal topography (TMS-4) in eyes that had undergone myopic laser-assisted in situ keratomileusis (LASIK)...
  30. Parisutham V, Lee S. Novel Functions and Regulation of Cryptic Cellobiose Operons in Escherichia coli. PLoS ONE. 2015;10:e0131928 pubmed publisher
    Presence of cellobiose as a sole carbon source induces mutations in the chb and asc operons of Escherichia coli and allows it to grow on cellobiose...
  31. Schiffman M, Boyle S, Raine Bennett T, Katki H, Gage J, Wentzensen N, et al. The Role of Human Papillomavirus Genotyping in Cervical Cancer Screening: A Large-Scale Evaluation of the cobas HPV Test. Cancer Epidemiol Biomarkers Prev. 2015;24:1304-10 pubmed publisher
    ..The test is approved for (i) atypical squamous cells of undetermined significance (ASC-US) triage to determine need for colposcopy, (ii) combined screening with cytology ("cotesting"), and (iii) primary ..
  32. Andrés A, Petrón M, Adámez J, Lopez M, Timón M. Food by-products as potential antioxidant and antimicrobial additives in chill stored raw lamb patties. Meat Sci. 2017;129:62-70 pubmed publisher
    ..A negative (CON) and a positive control (sodium ascorbate, ASC) were also included in the experiment...
  33. Coolen A, Bui B, Dietz V, Wang R, van Montfoort A, Mol B, et al. The treatment of post-hysterectomy vaginal vault prolapse: a systematic review and meta-analysis. Int Urogynecol J. 2017;28:1767-1783 pubmed publisher
    ..The anatomical results of the sacrocolpopexy (laparoscopic, robotic [RSC]. and abdominal [ASC]) are the best (62-91%), followed by the VM. However, the ranges of the anatomical outcome of VM were wide (43-97%)...
  34. Carey K, Mitchell J. Specialization as an Organizing Principle: The Case of Ambulatory Surgery Centers. Med Care Res Rev. 2017;:1077558717729228 pubmed publisher
    ..In contrast to studies of cost efficiency in specialty hospitals, our results provide evidence that supports the focused factory model of production in the ASC sector.
  35. Yue Y, Yang X, Zhang L, Xiao X, Nabar N, Lin Y, et al. Low-intensity pulsed ultrasound upregulates pro-myelination indicators of Schwann cells enhanced by co-culture with adipose-derived stem cells. Cell Prolif. 2016;49:720-728 pubmed publisher
    ..Effects of LIPUS and ASC co-culture on pro-myelination indicators of SCs were analysed by real-time PCR (RT-PCR), Western blotting and ..
  36. Birnbaum Y, Birnbaum G, Birnbaum I, Nylander S, Ye Y. Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine. Cardiovasc Drugs Ther. 2016;30:539-550 pubmed
    ..The ischemia-reperfusion injury increased myocardial mRNA levels of NLRP3, ASC, IL-1? and IL-6...
  37. Lao S, Xu J, Liu Y, Cai S, Lin L, Zhang J, et al. A comparative study of the influence of two types of PHEMA stents on the differentiation of ASCs to myocardial cells. Mol Med Rep. 2017;16:507-514 pubmed publisher
    ..two stent materials with the inducer control group revealed statistically significant differences in the rate of ASC differentiation (P<0.05)...
  38. Rozand V, Senefeld J, Hassanlouei H, Hunter S. Voluntary activation and variability during maximal dynamic contractions with aging. Eur J Appl Physiol. 2017;117:2493-2507 pubmed publisher
    ..Voluntary activation was assessed by superimposing an evoked contraction with transcranial magnetic stimulation (TMS) or with electrical stimulation over the muscle during maximal voluntary contractions (MVCs)...
  39. Guthrie M, Gilbert D, Huddleston D, Pedapati E, Horn P, Mostofsky S, et al. Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition. J Vis Exp. 2018;: pubmed publisher
    ..reproducible, child-friendly motor response inhibition task suitable for online Transcranial Magnetic Stimulation (TMS) characterization of primary motor cortex (M1) excitability and inhibition...
  40. Hirano M, Kubota S, Furuya S, Koizume Y, Tanaka S, Funase K. The acquisition of skilled finger movements is accompanied by the reorganization of the corticospinal system. J Neurophysiol. 2017;:jn.00667.2017 pubmed publisher
    ..voluntary movements produced during the SRTT and the passive movements evoked by transcranial magnetic stimulation (TMS) over the primary motor cortex into a set of 5 finger joint covariation patterns...
  41. Tervaniemi M, Katayama S, Skoog T, Siitonen H, Vuola J, Nuutila K, et al. NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis. Sci Rep. 2016;6:22745 pubmed publisher
    ..The characterization of inflammasome pathways provides further opportunities for therapy. Complementing previous transcriptome studies, our approach gives deeper insight into the gene regulation in psoriatic epidermis. ..
  42. Ramena G, Yin Y, Yu Y, Walia V, Elble R. CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation. PLoS ONE. 2016;11:e0147489 pubmed publisher
    ..domains were delimited by deletion analysis, revealing the site of interaction to be the transmembrane segment (TMS)...
  43. Chi W, Chen H, Li F, Zhu Y, Yin W, Zhuo Y. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma. J Neuroinflammation. 2015;12:137 pubmed publisher
    ..3 (NLRP3), phosphor-NF-κB p65, caspase-8, caspase-1, apoptosis-associated speck-like protein containing a CARD (ASC), and interleukin-1β (IL-1β)...
  44. Ehsan M, Singh K, Lovren F, Pan Y, Quan A, Mantella L, et al. Adiponectin limits monocytic microparticle-induced endothelial activation by modulation of the AMPK, Akt and NFκB signaling pathways. Atherosclerosis. 2016;245:1-11 pubmed publisher
    ..05) of LPS. LPS-induced MP expression of NLRP3 inflammasome and its key components, namely cleaved ASC, caspase-1 and IL-1β (pro- and cleaved), were markedly attenuated by adiponectin...
  45. Cai T, Shu Q, Liu P, Guo X, Ding X, Xue P, et al. Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling. J Lipid Res. 2016;57:388-97 pubmed publisher
    ..Here, we present an integrated novel method that combines a fast and robust TMS-diazomethane-based phosphate derivatization and isotopic labeling strategy, which enables simultaneous profiling ..
  46. Alpizar Reyes E, Román Guerrero A, Gallardo Rivera R, Varela Guerrero V, Cruz Olivares J, Pérez Alonso C. Rheological properties of tamarind (Tamarindus indica L.) seed mucilage obtained by spray-drying as a novel source of hydrocolloid. Int J Biol Macromol. 2018;107:817-824 pubmed publisher
    ..These results suggest that TMS could be applied in the production of foods that require additives with thickening capacity.
  47. Sarvestani S, McAuley J. The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection. Antiviral Res. 2017;148:32-42 pubmed publisher
    ..such as the nucleotide-binding oligomerization domain (NOD) like receptor proteins (NLRP), and an adapter protein, ASC, which critically activates pro-caspase-1...
  48. Ghasemzadeh Hasankolaei M, Eslaminejad M, Ghasemzadeh Hasankolaei M. Functional germ cells from non-testicular adult stem cells: A dream or reality?. Curr Stem Cell Res Ther. 2017;: pubmed publisher
    ..have begun their creative studies on generation of new GCs both in vitro and in vivo, and utilized different ASC types such as bone marrow mesenchymal stem cells (BM-MSCs), skin stem cells, pancreatic stem cells, and adipose ..
  49. Cortese F, Coppola G, Di Lenola D, Serrao M, Di Lorenzo C, Parisi V, et al. Excitability of the motor cortex in patients with migraine changes with the time elapsed from the last attack. J Headache Pain. 2017;18:2 pubmed publisher
    Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability...
  50. Davidson T, Tremblay F. Evidence of alterations in transcallosal motor inhibition as a possible long-term consequence of concussions in sports: A transcranial magnetic stimulation study. Clin Neurophysiol. 2016;127:3364-75 pubmed publisher
    ..we sought to further explore the long-term consequences of concussions with transcranial magnetic stimulation (TMS) by examining excitability changes both within and between hemispheres...
  51. Höckendorf U, Yabal M, Herold T, Munkhbaatar E, Rott S, Jilg S, et al. RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells. Cancer Cell. 2016;30:75-91 pubmed publisher
    ..Our data identify RIPK3 and the inflammasome as key tumor suppressors in AML. ..
  52. Ma M, Wang J, Dhandapani K, Brann D. NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury. Oxid Med Cell Longev. 2017;2017:6057609 pubmed publisher
    ..Expression of NLRP3 inflammasome components NLRP3 and apoptosis-associated speck-like protein containing a CARD (ASC), as well as its downstream products cleaved caspase-1 and interleukin-1β (IL-1β), was robustly ..
  53. Shain A, Kwok S, Folkins A, Kong C. Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results. Am J Surg Pathol. 2018;42:69-75 pubmed publisher
    ..cannot exclude HSIL, atypical glandular cells [AGC], or HPV16 atypical squamous cells of undetermined significance [ASC-US]). The impetus for this recommendation is to increase detection of missed high-grade disease...
  54. Wang H, Wang X, Zhang R, Wang Y, Cai M, Zhang Y, et al. Clustered repetitive transcranial magnetic stimulation for the prevention of depressive relapse/recurrence: a randomized controlled trial. Transl Psychiatry. 2017;7:1292 pubmed publisher
    ..The rTMS-containing regimens had considerably more certain side effects than did the ADP group. We concluded that TMS, whether as a mono- or additional therapy, is superior to antidepressants in preventing depressive relapse/..
  55. Hennig K, Antignac J, Bichon E, Morvan M, Miran I, Delaloge S, et al. Steroid hormone profiling in human breast adipose tissue using semi-automated purification and highly sensitive determination of estrogens by GC-APCI-MS/MS. Anal Bioanal Chem. 2018;410:259-275 pubmed publisher
    ..sample preparation method based on gel permeation chromatography and subsequent derivatization with trimethylsilyl (TMS) is presented. Progestagens and androgens were determined by GC-EI-MS/MS (LOQ 0.5 to 10 ng/g lipids)...
  56. Calbet A, Schmoker C, Russo F, Trottet A, Mahjoub M, Larsen O, et al. Non-proportional bioaccumulation of trace metals and metalloids in the planktonic food web of two Singapore coastal marine inlets with contrasting water residence times. Sci Total Environ. 2016;560-561:284-94 pubmed publisher
    We analyzed the concentrations of trace metals/metalloids (TMs) in the water, sediment and plankton of two semi-enclosed marine coastal inlets located north of Jurong Island and separated by a causeway (SW Singapore; May 2012-April 2013)...
  57. Masumoto J, Dowds T, Schaner P, Chen F, Ogura Y, Li M, et al. ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun. 2003;303:69-73 pubmed
    b>ASC is a pro-apoptotic protein containing a pyrin domain (PD) and a caspase-recruitment domain (CARD). A previous study suggests that ASC interacts with Ipaf, a member of the Apaf-1/Nod1 protein family...
  58. Stefanou M, Desideri D, Marquetand J, Belardinelli P, Zrenner C, Lerche H, et al. Motor cortex excitability in seizure-free STX1B mutation carriers with a history of epilepsy and febrile seizures. Clin Neurophysiol. 2017;128:2503-2509 pubmed publisher
    ..We explored this question using single- and paired-pulse transcranial magnetic stimulation (TMS) excitability markers...
  59. Li K, Li F, Li J, Wang H, Zheng X, Long J, et al. Increased survival of human free fat grafts with varying densities of human adipose-derived stem cells and platelet-rich plasma. J Tissue Eng Regen Med. 2017;11:209-219 pubmed publisher
    ..The residual fat volume of the 105 /ml ASC?+?PRP group was significantly higher than that of other treatment conditions after 90?days...
  60. Wen C, Yan H, Fu S, Qian Y, Wang D, Wang C. Allogeneic adipose-derived stem cells regenerate bone in a critical-sized ulna segmental defect. Exp Biol Med (Maywood). 2016;241:1401-9 pubmed publisher
    ..study and bilateral critical-sized defects (8 mm) of the ulna were created and divided into two groups: with ASC-DBM constructs or DBM alone...
  61. Cho H, Park J, Nam J, Chang Y, Park B, HOE H. Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades. J Cell Biochem. 2018;119:300-313 pubmed publisher
    ..Ascochlorin (ASC) has anti-metastatic, anti-angiogenic, and synergistic effect in various types of cancer cells...
  62. Noda Y, Barr M, Zomorrodi R, Cash R, Farzan F, Rajji T, et al. Evaluation of short interval cortical inhibition and intracortical facilitation from the dorsolateral prefrontal cortex in patients with schizophrenia. Sci Rep. 2017;7:17106 pubmed publisher
    ..established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short interval intracortical inhibition (SICI) and facilitation (ICF) combined with ..
  63. Sakai T. Convergent Synthesis of Fused Ring Systems in Large Polycyclic Ethers. Yakugaku Zasshi. 2017;137:1095-1101 pubmed publisher
    ..of this key ring expansion, we first focused on the reaction mechanism, in which an equatorial attack of TMS-diazomethane was determined to be the crucial step...
  64. Fromer M, Chang S, Hagaman A, Koko K, Nolan R, Zhang P, et al. The endothelial cell secretome as a novel treatment to prime adipose-derived stem cells for improved wound healing in diabetes. J Vasc Surg. 2018;68:234-244 pubmed publisher
    ..Mice were randomized to a control group, an unprimed ASC group, or a HUVEC-primed ASC group. Cellular therapies were injected into the ischemic muscle...
  65. Parsons M, Vertino P. Dual role of TMS1/ASC in death receptor signaling. Oncogene. 2006;25:6948-58 pubmed
    ..We identified a gene TMS1 (for Target of Methylation-mediated Silencing) that is subject to such epigenetic silencing in a significant ..
  66. Ahmad F, Mishra N, Ahrenstorf G, Franklin B, Latz E, Schmidt R, et al. Evidence of inflammasome activation and formation of monocyte-derived apoptosis-associated speck-like protein containing a caspase-recruitment domain specks in HIV-1 positive patients. AIDS. 2017;: pubmed publisher
    ..of the inflammasome adaptor apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) (PYCARD) is a hallmark of inflammasome activation...
  67. Douglas T, Vandrovcova M, Kročilová N, Keppler J, Zarubova J, Skirtach A, et al. Application of whey protein isolate in bone regeneration: Effects on growth and osteogenic differentiation of bone-forming cells. J Dairy Sci. 2018;101:28-36 pubmed publisher
    ..concentrations of WPI on behavior of human osteoblast-like Saos-2 cells, human adipose tissue-derived stem cells (ASC), and human neonatal dermal fibroblasts (FIB)...
  68. Lee R, Lin T, Lee S, Lee K, Christensen R. Importance of tumor extent in adenosquamous carcinoma of the head and neck: a retrospective cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:114-120 pubmed publisher
    ..aim of this study was to determine the correlates of survival for patients diagnosed with adenosquamous carcinoma (ASC) of the head and neck...
  69. Thom S, Bhopale V, Hu J, Yang M. Increased carbon dioxide levels stimulate neutrophils to produce microparticles and activate the nucleotide-binding domain-like receptor 3 inflammasome. Free Radic Biol Med. 2017;106:406-416 pubmed publisher
    ..the membrane phospholipid translocation enzymes flippase and floppase, and the critical inflammasome protein ASC (Apoptosis-associated Speck protein with CARD domain)...
  70. Monsuur H, van den Broek L, Jhingoerie R, Vloemans A, Gibbs S. Burn Eschar Stimulates Fibroblast and Adipose Mesenchymal Stromal Cell Proliferation and Migration but Inhibits Endothelial Cell Sprouting. Int J Mol Sci. 2017;18: pubmed publisher
    ..derived from dermis and adipose tissue, dermal fibroblasts and adipose tissue-derived mesenchymal stromal cells (ASC) was determined...
  71. Gu X, Li C, Yin F, Yang G. Adipose-derived stem cells in articular cartilage regeneration: current concepts and optimization strategies. Histol Histopathol. 2017;:11955 pubmed publisher
    ..Herein, we give an update on the latest research progress on ASCs, with a focus on the most promising optimization strategies for ASC-based therapy.
  72. Engel S, Markewitz R, Langguth B, Schecklmann M. Paired Associative Stimulation of the Temporal Cortex: Effects on the Auditory Steady-State Response. Front Psychiatry. 2017;8:227 pubmed publisher
    ..stimulation (PAS) is the repeated combination of a sensory stimulus with transcranial magnetic stimulation (TMS) in close temporal association...
  73. Liang J, Yokell Z, Nakmaili D, Gan R, Lu H. The effect of blast overpressure on the mechanical properties of a chinchilla tympanic membrane. Hear Res. 2017;354:48-55 pubmed publisher
    ..projection method, we observed the alteration of the static mechanical properties of post-blast chinchilla's TMs as compared to those of control TMs...
  74. Zhang S, Bai J, Ren S, Wang R, Zhang L, Zuo Y. Sodium butyrate restores ASC expression and induces apoptosis in LS174T cells. Int J Mol Med. 2012;30:1431-7 pubmed publisher
    ..Apoptosis-associated speck-like protein (ASC) is a pro-apoptotic signaling factor that is subjected to epigenetic silencing in human cancers...
  75. Gotfredsen H, Broløs L, Holmstrøm T, Sørensen J, Viñas Muñoz A, Kilde M, et al. Acetylenic scaffolding with subphthalocyanines - synthetic scope and elucidation of electronic interactions in dimeric structures. Org Biomol Chem. 2017;15:9809-9823 pubmed publisher
    ..Convenient conditions that allow for stepwise desilylations of trimethylsilyl (TMS) and triisopropylsilyl (TIPS) protected SubPc-decorated acetylenes using silver(i) fluoride were developed...
  76. Hilt P, Bartoli E, Ferrari E, Jacono M, Fadiga L, D Ausilio A. Action observation effects reflect the modular organization of the human motor system. Cortex. 2017;95:104-118 pubmed publisher
    ..similarly to action execution, facilitates the observer's motor system and Transcranial Magnetic Stimulation (TMS) has been instrumental in exploring the nature of these motor activities...
  77. Di Pizio A, Kruetzfeldt L, Cheled Shoval S, Meyerhof W, Behrens M, Niv M. Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case. Sci Rep. 2017;7:8223 pubmed publisher
    ..site-directed mutagenesis was used to characterize the agonist-bound conformation of ggTas2r1 binding site between TMs 3, 5, 6 and 7...
  78. Yu C, Kornmuller A, Brown C, Hoare T, Flynn L. Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion. Biomaterials. 2017;120:66-80 pubmed publisher
    ..b>ASC immunophenotype was maintained post expansion, with a trend for reduced expression of the cell adhesion receptors ..
  79. Di Franco A, Guasti D, Squecco R, Mazzanti B, Rossi F, Idrizaj E, et al. Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model. Stem Cells. 2016;34:1679-91 pubmed publisher
    ..Here, we generated a novel human model of brown adipose stem cells, hfB-ASC, derived for the first time from fetal interscapular brown fat depots...
  80. Yannuzzi N, Chang J, Brown G, Smiddy W. Cost-Utility of Evaluation for Posterior Vitreous Detachment and Prophylaxis of Retinal Detachment. Ophthalmology. 2018;125:43-50 pubmed publisher
    ..used to calculate associated modeled costs in a hospital/facility-based and nonfacility/ambulatory surgical center (ASC)-based setting...
  81. Yin Z, Deng T, Peterson L, Yu R, Lin J, Hamilton D, et al. Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation. Mol Cell Endocrinol. 2014;394:80-7 pubmed publisher
    ..These results uncover a dialogue regulated by interactions among T cell IFN? and adipocyte MHCII and NLRP3 inflammasome activity that appears to initiate and escalate adipose tissue inflammation during obesity. ..
  82. Noda Y, Zomorrodi R, Cash R, Barr M, Farzan F, Rajji T, et al. Characterization of the influence of age on GABAA and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG. Aging (Albany NY). 2017;9:556-572 pubmed publisher
    ..The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo...