ASAH1

Summary

Gene Symbol: ASAH1
Description: N-acylsphingosine amidohydrolase 1
Alias: ACDase, ASAH, PHP, PHP32, SMAPME, acid ceramidase, N-acylsphingosine amidohydrolase (acid ceramidase) 1, acid CDase, acylsphingosine deacylase
Species: human
Products:     ASAH1

Top Publications

  1. Bernardo K, Hurwitz R, Zenk T, Desnick R, Ferlinz K, Schuchman E, et al. Purification, characterization, and biosynthesis of human acid ceramidase. J Biol Chem. 1995;270:11098-102 pubmed
    Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) is the lysosomal enzyme catalyzing the hydrolysis of ceramide to sphingosine and free fatty acid. Its inherited deficiency causes ceramide accumulation in Farber's disease...
  2. Koch J, Gartner S, Li C, Quintern L, Bernardo K, Levran O, et al. Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease. J Biol Chem. 1996;271:33110-5 pubmed
    Human acid ceramidase ((AC) N-acylsphingosine amidohydrolase, EC 3.5. 1.23) hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid...
  3. Seelan R, Qian C, Yokomizo A, Bostwick D, Smith D, Liu W. Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer. 2000;29:137-46 pubmed
    The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered in several cancers, including prostate cancer...
  4. Saad A, Meacham W, Bai A, Anelli V, Elojeimy S, Mahdy A, et al. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther. 2007;6:1455-60 pubmed
    ..We previously determined that acid ceramidase (AC) is upregulated in 60% of primary prostate cancer (PCa) tissues, suggesting that AC may play a role in ..
  5. Beckham T, Lu P, Cheng J, Zhao D, Turner L, Zhang X, et al. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012;131:2034-43 pubmed publisher
    ..The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype through downstream ..
  6. Presa N, Clugston R, Lingrell S, Kelly S, Merrill A, Jana S, et al. Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice. Biochim Biophys Acta Mol Basis Dis. 2019;1865:14-25 pubmed publisher
    ..mice fed a HFD, with elevation of ceramides and other sphingolipids and higher expression of mRNAs for acid ceramidase (Asah1) and ceramide kinase (Cerk)...
  7. Sikora J, Dworski S, Jones E, Kamani M, Micsenyi M, Sawada T, et al. Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. Am J Pathol. 2017;187:864-883 pubmed publisher
    Farber disease is a rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease...
  8. Topaloglu H, Melki J. Spinal muscular atrophy associated with progressive myoclonus epilepsy. Epileptic Disord. 2016;18:128-134 pubmed
    ..SMA-PME is caused by mutation in the ASAH1 gene encoding acid ceramidase. Ceramide and the metabolites participate in various cellular events as lipid mediators...
  9. Gan J, Garcia V, Tian J, Tagliati M, Parisi J, Chung J, et al. Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy. Neuromuscul Disord. 2015;25:959-63 pubmed publisher
    ..Both disorders are autosomal recessive conditions caused by mutations in the ASAH1 gene encoding acid ceramidase. Farber disease is associated with joint deformities, lipomatous skin nodules, and often is fatal by 2-3 ..

More Information

Publications138 found, 100 shown here

  1. Yu F, Amintas S, Levade T, Medin J. Acid ceramidase deficiency: Farber disease and SMA-PME. Orphanet J Rare Dis. 2018;13:121 pubmed publisher
    b>Acid ceramidase (ACDase) deficiency is a spectrum of disorders that includes a rare lysosomal storage disorder called Farber disease (FD) and a rare epileptic disorder called spinal muscular atrophy with progressive myoclonic epilepsy (..
  2. Chauvin S, Yinon Y, Xu J, Ermini L, Sallais J, Tagliaferro A, et al. Aberrant TGFβ Signalling Contributes to Dysregulation of Sphingolipid Metabolism in Intrauterine Growth Restriction. J Clin Endocrinol Metab. 2015;100:E986-96 pubmed publisher
    ..Sphingosine accumulation was due to accelerated ceramide breakdown via increased acid ceramidase (ASAH1) expression/activity caused by augmented TGFβ signalling via the ALK5/SMAD2 pathway...
  3. Tirodkar T, Lu P, Bai A, Scheffel M, Gencer S, Garrett Mayer E, et al. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. J Biol Chem. 2015;290:13157-67 pubmed publisher
    ..qRT-PCR analysis revealed that only expression of acid ceramidase (ASAH1) was increased. The increase in acid ceramidase was confirmed by expression and activity analyses...
  4. Yu F, Sajdak B, Sikora J, Salmon A, Nagree M, Gurka J, et al. Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment. Am J Pathol. 2019;189:320-338 pubmed publisher
    ..FD is caused by mutations in the ASAH1 gene, resulting in deficient acid ceramidase (ACDase) activity. Patients with ACDase deficiency exhibit a broad clinical spectrum...
  5. Rajput V, Karthikeyan M, Ramasamy S. Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization. Int J Biol Macromol. 2019;122:587-593 pubmed publisher
    Acid ceramidase (N-acylsphingosine deacylase EC 3.5.1.23; AC) catalyzes the hydrolysis of ceramide into sphingosine (SPH) and free fatty acid. Zebrafish acid ceramidase (AC) has 60% homology with the human AC)...
  6. Li F, Xu R, Low B, Lin C, Garcia Barros M, Schrandt J, et al. Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018;32:3058-3069 pubmed publisher
    ..mainly from the hydrolysis of ceramides by the action of ceramidases that are encoded by 5 distinct genes, acid ceramidase 1 ( ASAH1)/ Asah1, ASAH2/ Asah2, alkaline ceramidase 1 ( ACER1)/ Acer1, ACER2/ Acer2, and ACER3/ Acer3, in ..
  7. Taguchi Y, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, et al. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. J Neurosci. 2017;37:9617-9631 pubmed publisher
    ..These data indicate that ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are ..
  8. Sugano E, Edwards G, Saha S, Wilmott L, Grambergs R, Mondal K, et al. Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress. J Lipid Res. 2019;60:30-43 pubmed publisher
    ..The lysosomal breakdown of Cer by acid ceramidase [N-acylsphingosine amidohydrolase (ASAH)1] into sphingosine (Sph) is the major source for Sph 1-..
  9. Kraljević T, Harej A, Sedic M, Pavelić S, Stepanić V, Drenjancevic D, et al. Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole-coumarin hybrids. Eur J Med Chem. 2016;124:794-808 pubmed publisher
    ..5-lipoxygenase (5-LO) activity and perturbation of sphingolipid signaling by interfering with intracellular acid ceramidase (ASAH) activity...
  10. Ehlert K, Levade T, Di Rocco M, Lanino E, Albert M, Fuhrer M, et al. Allogeneic hematopoietic cell transplantation in Farber disease. J Inherit Metab Dis. 2018;: pubmed publisher
    Farber disease (FD) is a rare, lysosomal storage disorder caused by deficient acid ceramidase activity...
  11. Frohbergh M, He X, Schuchman E. The molecular medicine of acid ceramidase. Biol Chem. 2015;396:759-65 pubmed publisher
    Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23; AC) is the lipid hydrolase responsible for the degradation of ceramide into sphingosine and free fatty acids within lysosomes...
  12. Gebai A, Gorelik A, Li Z, Illes K, Nagar B. Structural basis for the activation of acid ceramidase. Nat Commun. 2018;9:1621 pubmed publisher
    b>Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes...
  13. Doan N, Nguyen H, Al Gizawiy M, Mueller W, Sabbadini R, Rand S, et al. Acid ceramidase confers radioresistance to glioblastoma cells. Oncol Rep. 2017;38:1932-1940 pubmed publisher
    ..This study demonstrates that GBMs acquire resistance to radiation via upregulation of acid ceramidase (ASAH1) and sphingosine?1-phosphate (Sph-1P)...
  14. Cozma C, Iurascu M, Eichler S, Hovakimyan M, Brandau O, Zielke S, et al. C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease. Sci Rep. 2017;7:6149 pubmed publisher
    Farber disease (FD) is a rare autosomal recessive disease caused by mutations in the acid ceramidase gene (ASAH1). Low ceramidase activity results in the accumulation of fatty substances, mainly ceramides...
  15. Leclerc J, Garandeau D, Pandiani C, Gaudel C, Bille K, Nottet N, et al. Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells. Oncogene. 2019;38:1282-1295 pubmed publisher
    ..Here, we show that the acid ceramidase ASAH1, which controls sphingolipid metabolism, acted as a rheostat of the phenotypic switch in melanoma cells...
  16. White Gilbertson S, Lu P, Norris J, Voelkel Johnson C. Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis. J Lipid Res. 2019;: pubmed publisher
    ..Here we show that expression of acid ceramidase (ASAH1), an enzyme in the sphingolipid pathway linked to therapy resistance and poor outcomes, is elevated in ..
  17. Baspinar M, Özyurt R, Kus G, Kutlay O, Ozkurt M, Erkasap N, et al. Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line. Bratisl Lek Listy. 2017;118:391-393 pubmed publisher
    The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. The cell lines were treated with 50 µM of ceranib-2...
  18. Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, et al. Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Sci Rep. 2017;7:7411 pubmed publisher
    b>Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine...
  19. Qin N, Bayat A, Trevisi E, Minuti A, Kairenius P, Viitala S, et al. Dietary supplement of conjugated linoleic acids or polyunsaturated fatty acids suppressed the mobilization of body fat reserves in dairy cows at early lactation through different pathways. J Dairy Sci. 2018;101:7954-7970 pubmed publisher
    ..In conclusion, the CLA and HSO diets induced a shift in energy partitioning toward AT instead of mammary gland during lactation through the regulation of different pathways. ..
  20. Brown R, Epling B, Staff I, Fortunato G, Grady J, McCullough L. Polyuria and cerebral vasospasm after aneurysmal subarachnoid hemorrhage. BMC Neurol. 2015;15:201 pubmed publisher
    Natriuresis with polyuria is common after aneurysmal subarachnoid hemorrhage (aSAH)...
  21. Rubboli G, Veggiotti P, Pini A, Berardinelli A, Cantalupo G, Bertini E, et al. Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations in ASAH1. Epilepsia. 2015;56:692-8 pubmed publisher
    ..myoclonic epilepsy (SMA-PME), a rare condition caused by mutations in the N-acylsphingosine amidohydrosilase 1 (ASAH1) gene...
  22. Wang D, Lin P, Lin Z, Shu Fa Zheng -, Shang Guan H, De Zhi Kang -, et al. Lower hemoglobin levels are associated with acute seizures in patients with ruptured cerebral aneurysms. World Neurosurg. 2019;: pubmed publisher
    ..that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH)...
  23. Foreman P, Chua M, Harrigan M, Fisher W, Tubbs R, Shoja M, et al. Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: A case-control study. Clin Neurol Neurosurg. 2015;139:66-9 pubmed publisher
    Aneurysm re-rupture is associated with significant morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH)...
  24. Braun F, Rinschen M, Bartels V, Frommolt P, Habermann B, Hoeijmakers J, et al. Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging (Albany NY). 2016;8:441-57 pubmed
    ..Moreover, ceramidase Asah1 was highly expressed in aged kidneys, consistent with a decrease in ceramide C16...
  25. Revilla Pacheco F, Lerma C, Franco Granillo J, Manrique Guzmán S. Prevalence of Aneurysmal Subarachnoid Hemorrhage Safety Indicators and Their Relation with Health Care Outcomes in a Mexican Population. World Neurosurg. 2016;91:1-5 pubmed publisher
    Aneurysmal subarachnoid hemorrhage (ASAH) is a serious and unstable condition. Patient safety indicators (PSI) are a group of potentially preventable events in patient health care...
  26. Kamar C, Ali A, Altun D, Orhun G, Sabanci A, Sencer A, et al. Evaluation of risk factors and development of acute kidney injury in aneurysmal subarachnoid hemorrhage, head injury, and severe sepsis/septic shock patients during ICU treatment. Ulus Travma Acil Cerrahi Derg. 2017;23:39-45 pubmed publisher
    ..in trauma, neurosurgery, or general ICU departments (due to head injury, aneurysmal subarachnoid hemorrhage [aSAH], or severe sepsis/septic shock, respectively) were assessed for incidence, risk factors, and development of AKI...
  27. Hänggi D, Etminan N, MacDonald R, Steiger H, Mayer S, Aldrich F, et al. NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage. Neurocrit Care. 2015;23:274-84 pubmed publisher
    Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality...
  28. van der Bilt I, Hasan D, van den Brink R, Cramer M, van der Jagt M, Van Kooten F, et al. Time course and risk factors for myocardial dysfunction after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2015;76:700-5; discussion 705-6 pubmed publisher
    ..WMAs) are independent risk factors for a poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH)...
  29. Sin J, Shafeeq H, Levy Z. Nimodipine for the treatment of otolaryngic indications. Am J Health Syst Pharm. 2018;75:1369-1377 pubmed publisher
    ..indicated for the improvement of neurologic outcomes in adult patients with aneurysmal subarachnoid hemorrhage (aSAH). However, other oral and i.v...
  30. Savarraj J, Parsha K, Hergenroeder G, Zhu L, Bajgur S, Ahn S, et al. Systematic model of peripheral inflammation after subarachnoid hemorrhage. Neurology. 2017;88:1535-1545 pubmed publisher
    To investigate inflammatory processes after aneurysmal subarachnoid hemorrhage (aSAH) with network models...
  31. Backer Grøndahl A, Lindal S, Lorentzen M, Eldevik P, Vorren T, Kristiansen B, et al. A new non-craniotomy model of subarachnoid hemorrhage in the pig: a pilot study. Lab Anim. 2016;50:379-89 pubmed publisher
    ..investigations of the pig brain showed a typical blood distribution consistent with human aneurysmal SAH (aSAH) autopsy data...
  32. Cossu G, Messerer M, Stocchetti N, Levivier M, Daniel R, Oddo M. Intracranial pressure and outcome in critically ill patients with aneurysmal subarachnoid hemorrhage: a systematic review. Minerva Anestesiol. 2016;82:684-96 pubmed
    Evidences supporting the use of intracranial pressure (ICP) monitoring after aneurysmal subarachnoid hemorrhage (aSAH) are limited...
  33. Rots M, Van Putten M, Hoedemaekers C, Horn J. Continuous EEG Monitoring for Early Detection of Delayed Cerebral Ischemia in Subarachnoid Hemorrhage: A Pilot Study. Neurocrit Care. 2016;24:207-16 pubmed publisher
    Early identification of delayed cerebral ischemia (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) is a major challenge...
  34. Sugimoto K, Shirao S, Koizumi H, Inoue T, Oka F, Maruta Y, et al. Continuous Monitoring of Spreading Depolarization and Cerebrovascular Autoregulation after Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 2016;25:e171-7 pubmed publisher
    Delayed cerebral ischemia (DCI) is a prominent complication after aneurysmal subarachnoid hemorrhage (aSAH)...
  35. Wang Y, Tian Y, Wang D, Wei H, Zhao Z, Jiang R, et al. High Angiopoietin-1 levels predict a good functional outcome within 72 h of an aneurysmal subarachnoid hemorrhage: A prospective study from a single center. J Neurol Sci. 2015;356:72-6 pubmed publisher
    The consequences of aneurysmal subarachnoid hemorrhage (aSAH) are lifelong and fatal. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) play an important role in the regulation of vascular structure and function...
  36. Sandow N, Diesing D, Sarrafzadeh A, Vajkoczy P, Wolf S. Nimodipine Dose Reductions in the Treatment of Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2016;25:29-39 pubmed publisher
    The incidence of cerebral infarction and poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH) is reduced by oral nimodipine but acute effects of the drug may include a significant decrease in mean arterial blood ..
  37. Rowland M, Garry P, Westbrook J, Corkill R, Antoniades C, Pattinson K. Acute impairment of saccadic eye movements is associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2017;127:754-760 pubmed publisher
    ..infarction remains a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH)...
  38. Bao X, Tian J, Ji T, Chang X. [A case report of childhood Farber's disease and literature review]. Zhonghua Er Ke Za Zhi. 2017;55:54-58 pubmed publisher
    ..b>Conclusion: Farber disease is a rare autosomal recessive disease caused by deficiency of lysosomal acid ceramidase.Histopathology of granulomatous tissue plays an important role in the early diagnosis.
  39. Teo M, Guilfoyle M, Turner C, Kirkpatrick P. What Factors Determine Treatment Outcome in Aneurysmal Subarachnoid Hemorrhage in the Modern Era? A Post Hoc STASH Analysis. World Neurosurg. 2017;105:270-281 pubmed publisher
    The management of aneurysmal subarachnoid hemorrhage (aSAH) has changed dramatically in the last few decades with the publication of a few major studies, including ISAT (International Subarachnoid Aneurysm Trial, the International ..
  40. Bender M, Wendt H, Monarch T, Lin L, Jiang B, Huang J, et al. Shifting Treatment Paradigms for Ruptured Aneurysms from Open Surgery to Endovascular Therapy Over 25 Years. World Neurosurg. 2017;106:919-924 pubmed publisher
    ..We assessed aneurysm location and treatment modality in aneurysmal subarachnoid hemorrhage (aSAH) over the past 25 years...
  41. Zafar S, Postma E, Biswal S, Fleuren L, Boyle E, Bechek S, et al. Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2018;28:184-193 pubmed publisher
    ..physiological parameters that in combination predict neurologic outcomes after aneurysmal subarachnoid hemorrhage (aSAH). We conducted a single-center retrospective cohort study of patients admitted with aSAH between 2011 and 2016...
  42. Ray B, Tinsley L, Ford L, Thompson D, Sidorov E, Bohnstedt B. Trends of Platelet Volume Index Predicts Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. World Neurosurg. 2018;111:e624-e631 pubmed publisher
    Delayed cerebral ischemia (DCI) is a major cause of disability after aneurysmal subarachnoid hemorrhage (aSAH)...
  43. van Donkelaar C, Bakker N, Veeger N, Uyttenboogaart M, Metzemaekers J, Luijckx G, et al. Predictive Factors for Rebleeding After Aneurysmal Subarachnoid Hemorrhage: Rebleeding Aneurysmal Subarachnoid Hemorrhage Study. Stroke. 2015;46:2100-6 pubmed publisher
    Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating type of stroke associated with high morbidity and mortality. One of the most feared complications is an early rebleeding before aneurysm repair...
  44. Inouye S, Jin D, Cen S, Nguyen P, Renda N, Amar A, et al. Trends in the use of pulmonary artery catheterization in the aneurysmal subarachnoid hemorrhage population. J Clin Neurosci. 2016;31:133-6 pubmed publisher
    ..However, none to date have looked primarily at trends in the aneurysmal subarachnoid hemorrhage (aSAH) population...
  45. Mohme M, Sauvigny T, Grensemann J, Söffker G, Kluge S, Westphal M, et al. Irreversible Total Loss of Brain Function and Organ Donation in Patients with Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2017;105:492-497 pubmed publisher
    Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening disease with an often fatal clinical course leading to irreversible loss of brain function (ILBF) (i.e., brain death)...
  46. Allen B, Forgacs P, Fakhar M, Wu X, Gerber L, Boddu S, et al. Association of Seizure Occurrence with Aneurysm Treatment Modality in Aneurysmal Subarachnoid Hemorrhage Patients. Neurocrit Care. 2018;29:62-68 pubmed publisher
    Data on new-onset seizures after treatment of aneurysmal subarachnoid hemorrhage (aSAH) patients are limited and variable...
  47. Park J, Eliyahu E, Narla G, Difeo A, Martignetti J, Schuchman E. KLF6 is one transcription factor involved in regulating acid ceramidase gene expression. Biochim Biophys Acta. 2005;1732:82-7 pubmed
    b>Acid ceramidase (AC; E.C.3.5.1.23) activity is required to hydrolyze ceramide into sphingosine. An inherited deficiency of this enzymatic activity leads to the lipid storage disorder, Farber Lipogranulomatosis...
  48. Davies B, Chung K, Dulhanty L, Galea J, Patel H. Pre-protection re-haemorrhage following aneurysmal subarachnoid haemorrhage: Where are we now?. Clin Neurol Neurosurg. 2015;135:22-6 pubmed publisher
    Re-haemorrhage is a negative, prognostic predictor of outcome in aneurysmal subarachnoid haemorrhage (aSAH)...
  49. Cremers C, Vos P, van der Schaaf I, Velthuis B, Vergouwen M, Rinkel G, et al. CT perfusion during delayed cerebral ischemia after subarachnoid hemorrhage: distinction between reversible ischemia and ischemia progressing to infarction. Neuroradiology. 2015;57:897-902 pubmed publisher
    Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) can be reversible or progress to cerebral infarction...
  50. Dai J, Cai J, Lin Q, Chen X, Lu C, Sun J, et al. Thioredoxin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage. J Neurol Sci. 2016;363:84-9 pubmed publisher
    ..was to establish the relationship between serum Trx levels and prognosis of aneurysmal subarachnoid hemorrhage (aSAH)...
  51. Nakagawa D, Cushing C, Nagahama Y, Allan L, Hasan D. Quantitative Susceptibility Mapping as a Possible Tool to Radiographically Diagnose Sentinel Headache Associated with Intracranial Aneurysm: Case Report. World Neurosurg. 2017;103:954.e1-954.e4 pubmed publisher
    ..SH) occurs before aneurysm rupture in an estimated 15%-60% of cases of aneurysmal subarachnoid hemorrhage (aSAH)...
  52. Al Jehani H, Angle M, Marcoux J, Teitelbaum J. Early abnormal transient hyperemic response test can predict delayed ischemic neurologic deficit in subarachnoid hemorrhage. Crit Ultrasound J. 2018;10:1 pubmed publisher
    ..Patients diagnosed with aSAH in which the THRT was performed within the first 24-48 h of admission were included in the study...
  53. McLaughlin D, Margretta M, Freeman W. Aneurysmal Subarachnoid Hemorrhage Mortality After Implementation of Nocturnist Advanced Practice Provider Coverage. J Neurosci Nurs. 2018;50:102-104 pubmed publisher
    ..This study is a retrospective review of healthcare outcomes of aneurysmal subarachnoid hemorrhage (aSAH) patients from 2013 and 2016, after implementation of specialty-trained neurocritical care nocturnist APPs...
  54. Varvarousi G, Xanthos T, Sarafidou P, Katsioula E, Georgiadou M, Eforakopoulou M, et al. Role of levosimendan in the management of subarachnoid hemorrhage. Am J Emerg Med. 2016;34:298-306 pubmed publisher
    Aneurysmal subarachnoid hemorrhage (aSAH) is one of the leading causes of neurologic disability accounting for dismal long term survival rates. aSAH leads to a sudden increase in intracranial pressure and a massive sympathetic discharge...
  55. Rumalla K, Reddy A, Mittal M. Association of Recreational Marijuana Use with Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 2016;25:452-60 pubmed publisher
    Our objective was to evaluate the effect of cannabis use on hospitalizations for aneurysmal subarachnoid hemorrhage (aSAH)...
  56. Cai J, Sun J, Yu Z. Serum mannose-binding lectin levels after aneurysmal subarachnoid hemorrhage. Acta Neurol Scand. 2016;134:360-367 pubmed publisher
    ..lectin (MBL) is a key molecule of complement system, which is activated after aneurysmal subarachnoid hemorrhage (aSAH)...
  57. Ackermark P, Schepers V, Post M, Rinkel G, Passier P, Visser Meily J. Longitudinal course of depressive symptoms and anxiety after aneurysmal subarachnoid hemorrhage. Eur J Phys Rehabil Med. 2017;53:98-104 pubmed publisher
    ..and depression are present in almost half of the patients who survive an aneurysmal subarachnoid hemorrhage (aSAH), but the long-term course is unknown...
  58. Boulouis G, Labeyrie M, Raymond J, Rodriguez Régent C, Lukaszewicz A, Bresson D, et al. Treatment of cerebral vasospasm following aneurysmal subarachnoid haemorrhage: a systematic review and meta-analysis. Eur Radiol. 2017;27:3333-3342 pubmed publisher
    To examine the clinical outcome of aneurysmal subarachnoid haemorrhage (aSAH) patients exposed to cerebral vasospasm (CVS)-targeted treatments in a meta-analysis and to evaluate the efficacy of intra-arterial (IA) approaches in patients ..
  59. Hendrix P, Foreman P, Starke R, Harrigan M, Fisher W, Vyas N, et al. Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture. World Neurosurg. 2017;102:253-257 pubmed publisher
    ..Eight common endothelin SNPs were assessed using blood samples from aneurysmal subarachnoid hemorrhage (aSAH) patients enrolled in the Cerebral Aneurysm Renin Angiotensin System study, a prospective, 2-center study that ..
  60. Brown S, Fifield S, Pizzi M, Alejos D, Richie A, Dinh T, et al. A Preliminary Observational Study of Anovulatory Uterine Bleeding After Aneurysmal Subarachnoid Hemorrhage. J Neurosci Nurs. 2017;49:363-371 pubmed publisher
    It was observed that women with aneurysmal subarachnoid hemorrhage (aSAH) tended to have earlier menses than a typical 21- to 28-day cycle. The goal was to determine whether there is an association between aSAH and early onset of menses...
  61. Lee H, Kim W, Yeon J, Kim J, Kim K, Jeon P, et al. Contrast-Induced Acute Kidney Injury after Coil Embolization for Aneurysmal Subarachnoid Hemorrhage. Yonsei Med J. 2018;59:107-112 pubmed publisher
    ..and clinical implication of CI-AKI after coil embolization in patients with an aneurysmal subarachnoid hemorrhage (aSAH). Between January 2005 and March 2016, 192 patients who underwent coil embolization were enrolled in this study...
  62. Huhtakangas J, Lehto H, Seppä K, Kivisaari R, Niemelä M, Hernesniemi J, et al. Long-Term Excess Mortality After Aneurysmal Subarachnoid Hemorrhage: Patients With Multiple Aneurysms at Risk. Stroke. 2015;46:1813-8 pubmed publisher
    There is high case-fatality rate and loss of productive life-years related to aneurysmal subarachnoid hemorrhage (aSAH) but data on long-term survival of patients with aSAH are scarce...
  63. Hamming A, Mulder I, Gathier C, van den Bergh W, Dankbaar J, Hoff R, et al. Spreading depolarization-modulating drugs and delayed cerebral ischemia after subarachnoid hemorrhage: A hypothesis-generating retrospective clinical study. J Neurol Sci. 2016;366:224-228 pubmed publisher
    ..cerebral ischemia (DCI) occurs in approximately one-third of patients with aneurysmal subarachnoid hemorrhage (aSAH). A proposed underlying mechanism for DCI is spreading depolarization (SD)...
  64. Sadahiro H, Shirao S, Yoneda H, Ishihara H, Oku T, Inamura A, et al. Decreased Flow Velocity with Transcranial Color-Coded Duplex Sonography Correlates with Delayed Cerebral Ischemia due to Peripheral Vasospasm of the Middle Cerebral Artery. J Stroke Cerebrovasc Dis. 2016;25:2352-9 pubmed publisher
    ..cause of delayed cerebral ischemia (DCI) in worsening patient outcome after aneurysmal subarachnoid hemorrhage (aSAH)...
  65. Fujimura M, Joo J, Kim J, Hatta M, Yokoyama Y, Tominaga T. Preventive Effect of Clazosentan against Cerebral Vasospasm after Clipping Surgery for Aneurysmal Subarachnoid Hemorrhage in Japanese and Korean Patients. Cerebrovasc Dis. 2017;44:59-67 pubmed publisher
    ..has been explored worldwide for the prophylaxis of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH)...
  66. Bijlenga P, Gondar R, Schilling S, Morel S, Hirsch S, Cuony J, et al. PHASES Score for the Management of Intracranial Aneurysm: A Cross-Sectional Population-Based Retrospective Study. Stroke. 2017;48:2105-2112 pubmed publisher
    ..into 4 groups: stable UIA; growing observed UIA; immediately treated UIA; and aneurysmal subarachnoid hemorrhage (aSAH)...
  67. Pinggera D, Kerschbaumer J, Petr O, Ortler M, Thome C, Freyschlag C. The Volume of the Third Ventricle as a Prognostic Marker for Shunt Dependency After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2017;108:107-111 pubmed publisher
    Hydrocephalus is a common sequelae of aneurysmal subarachnoid hemorrhage (aSAH). However, in daily routine it is difficult to predict a patient's need for ventricular shunt placement in the course of the disease...
  68. Duan Y, Wright J, Wright C, Shammassian B, Tatsuoka C, Bambakidis N. Reliable Identification of Benign Clinical Course in Aneurysmal Subarachnoid Hemorrhage: A Simple and Qualitative Algorithm. Neurosurgery. 2017;: pubmed publisher
    A reliable method to specifically identify low vasospasm risk in aneurysmal subarachnoid hemorrhage (aSAH) patients has not been previously proposed.
  69. Nozoe M, Kanai M, Kubo H, Kobayashi M, Yamamoto M, Shimada S, et al. Quadriceps muscle thickness changes in patients with aneurysmal subarachnoid hemorrhage during the acute phase. Top Stroke Rehabil. 2017;:1-5 pubmed publisher
    Background Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition that often leads to severe disability in relatively young and healthy people...
  70. Xu N, Meng H, Liu T, Feng Y, Qi Y, Wang H. Continuous lumbar cistern drainage before surgical clipping for aneurysmal subarachnoid hemorrhage. World Neurosurg. 2018;: pubmed publisher
    ..We evaluated the role of LD in the preoperative management of patients with aneurysmal SAH (aSAH)...
  71. Lucki N, Li D, Bandyopadhyay S, Wang E, Merrill A, Sewer M. Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor. Mol Cell Biol. 2012;32:4419-31 pubmed publisher
    ..Sphingosine (SPH) is a ligand for SF-1. Moreover, suppression of expression of acid ceramidase (ASAH1), an enzyme that produces SPH, increases the transcription of multiple steroidogenic genes...
  72. Höllig A, Remmel D, Stoffel Wagner B, Schubert G, Coburn M, Clusmann H. Association of early inflammatory parameters after subarachnoid hemorrhage with functional outcome: A prospective cohort study. Clin Neurol Neurosurg. 2015;138:177-83 pubmed publisher
    Early brain injury after aneurysmal subarachnoid hemorrhage (aSAH) comprises a pronounced neuroinflammatory reaction. Nevertheless, its relevance for functional outcome and its role as outcome predictor remains uncertain...
  73. Ding Y, Sun B, Jiang J, Zhang Q, Lu J, Gao G. Increased serum concentrations of signal peptide-Cub-Egf domain-containing protein-1 in patients with aneurysmal subarachnoid hemorrhage. Clin Chim Acta. 2016;459:117-122 pubmed publisher
    ..the potential prognostic value of serum SCUBE1 concentrations in patients with aneurysmal subarachnoid hemorrhage (aSAH). Serum SCUBE1 concentrations of 125 patients and 125 controls were determined...
  74. AlMatter M, Bhogal P, Aguilar Perez M, Hellstern V, Bazner H, Ganslandt O, et al. Evaluation of safety, efficacy and clinical outcome after endovascular treatment of aneurysmal subarachnoid hemorrhage in coil-first setting. A 10-year series from a single center. J Neuroradiol. 2018;45:349-356 pubmed publisher
    ..All patients with aneurysmal subarachnoid hemorrhage (aSAH) treated between 2007 and 2016 were retrospectively reviewed and divided according to initial treatment into an EVT ..
  75. See A, Wu K, Lai P, Gross B, Du R. Risk factors for hyponatremia in aneurysmal subarachnoid hemorrhage. J Clin Neurosci. 2016;32:115-8 pubmed publisher
    Hyponatremia occurs commonly in patients with aneurysmal subarachnoid hemorrhage (aSAH). Our objective was to determine the time course of, and factors associated with, hyponatremia after aSAH...
  76. Bar J, Linke T, Ferlinz K, Neumann U, Schuchman E, Sandhoff K. Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Hum Mutat. 2001;17:199-209 pubmed
    ..autosomal recessively inherited sphingolipid storage disorder due to the deficient activity of lysosomal acid ceramidase, leading to the accumulation of ceramide in cells and tissues...
  77. Lucki N, Sewer M. The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells. Biochim Biophys Acta. 2009;1791:706-13 pubmed publisher
    b>Acid ceramidase (encoded by ASAH1) is a lipid hydrolase that catalyzes the conversion of ceramide (cer) into sphingosine (SPH) and a free fatty acid...
  78. Uchida Y, Houben E, Park K, Douangpanya S, Lee Y, Wu B, et al. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010;130:2472-80 pubmed publisher
    ..Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after L- and H-UVB, but returned to normal only in L-UVB ..
  79. Lucki N, Sewer M. Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J Biol Chem. 2011;286:19399-409 pubmed publisher
    ..b>Acid ceramidase (ASAH1) plays a pivotal role in regulating the intracellular concentration of these two metabolites by ..
  80. Hanker L, Karn T, Holtrich U, Gätje R, Rody A, Heinrich T, et al. Acid ceramidase (AC)--a key enzyme of sphingolipid metabolism--correlates with better prognosis in epithelial ovarian cancer. Int J Gynecol Pathol. 2013;32:249-57 pubmed publisher
    b>Acid ceramidase (AC), a key enzyme of sphingolipid metabolism, seems to play an important role in cancer progression. The objective of this study was to explore the expression of AC in ovarian cancer and its impact on prognosis...
  81. Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, et al. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016;291:2422-34 pubmed publisher
    b>Acid ceramidase (AC) is a lysosomal cysteine amidase that controls sphingolipid signaling by lowering the levels of ceramides and concomitantly increasing those of sphingosine and its bioactive metabolite, sphingosine 1-phosphate...
  82. Buunk A, Spikman J, Veenstra W, van Laar P, Metzemaekers J, van Dijk J, et al. Social cognition impairments after aneurysmal subarachnoid haemorrhage: Associations with deficits in interpersonal behaviour, apathy, and impaired self-awareness. Neuropsychologia. 2017;103:131-139 pubmed publisher
    Behavioural disturbances are frequently found after aneurysmal subarachnoid haemorrhage (aSAH). Social cognition impairments have been suggested as a possible underlying mechanism for behavioural problems...
  83. Sokolowski J, Chen C, Ding D, Buell T, Raper D, Ironside N, et al. Endovascular treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage: predictors of outcome and retreatment. J Neurointerv Surg. 2017;: pubmed publisher
    ..therapy has been widely adopted for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH), its effect on clinical outcomes remains incompletely understood...
  84. Rajajee V. Grading scales in Subarachnoid Hemorrhage- many options, but do we have a winner?. Eur J Neurol. 2017;: pubmed publisher
    Grading the severity of Aneurysmal Subarachnoid Hemorrhage (aSAH) is essential, for several reasons- to provide a reliable prognosis, establish comparability across groups in research studies and quality assessments, follow the progress ..
  85. Mehta T, Datta N, Patel S, Mehta K, Hussain M, Kureshi I, et al. Trends in Endovascular Treatment of Aneurysmal Subarachnoid Hemorrhages. Interv Neurol. 2017;6:236-241 pubmed publisher
    Aneurysmal subarachnoid hemorrhage (aSAH) accounts for 5% of all strokes; 30-day mortality is as high as 40%...
  86. Rahmanian A, Jamali M, Bagheri Lankarani K, Ghahramani S. Aneurysmal subarachnoid haemorrhage (aSAH): Five consecutive years' experience of Fars province, Iran. PLoS ONE. 2017;12:e0189005 pubmed publisher
    ..Aneurysmal subarachnoid haemorrhage (aSAH) plays a critical role in the potential loss of life as its sufferers are usually of a young age...
  87. Eliyahu E, Shtraizent N, He X, Chen D, Shalgi R, Schuchman E. Identification of cystatin SA as a novel inhibitor of acid ceramidase. J Biol Chem. 2011;286:35624-33 pubmed publisher
    Autoproteolytic cleavage of the inactive acid ceramidase (AC) precursor into the active heterodimer exposes a free cysteine residue, leading us to study whether AC could be regulated by one or more members of the cystatin family...
  88. Lucki N, Bandyopadhyay S, Wang E, Merrill A, Sewer M. Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression. Mol Endocrinol. 2012;26:228-43 pubmed publisher
    ..b>Acid ceramidase (ASAH1) directly regulates the intracellular balance of Cer, SPH, and SPH-1-phosphate by catalyzing the ..
  89. Tan S, Liu X, Fox T, Barth B, Sharma A, Turner S, et al. Acid ceramidase is upregulated in AML and represents a novel therapeutic target. Oncotarget. 2016;7:83208-83222 pubmed publisher
    ..b>Acid ceramidase (AC) catalyzes ceramide breakdown to sphingosine, the precursor for S1P...
  90. Alotaibi N, Elkarim G, Samuel N, Ayling O, Guha D, Fallah A, et al. Effects of decompressive craniectomy on functional outcomes and death in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Neurosurg. 2017;127:1315-1325 pubmed publisher
    OBJECTIVE Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) (World Federation of Neurosurgical Societies Grade IV or V) are often considered for decompressive craniectomy (DC) as a rescue therapy for refractory ..
  91. Skoch J, Tahir R, Abruzzo T, Taylor J, Zuccarello M, Vadivelu S. Predicting symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage with an artificial neural network in a pediatric population. Childs Nerv Syst. 2017;33:2153-2157 pubmed publisher
    ..identify symptomatic cerebral vasospasm (SCV) in adults presenting after aneurysmal subarachnoid hemorrhage (aSAH). Although SCV is unusual in children with aSAH, the clinical consequences are severe...
  92. Wong G, Mak J, Wong A, Zheng V, Poon W, Abrigo J, et al. Minimum Clinically Important Difference of Montreal Cognitive Assessment in aneurysmal subarachnoid hemorrhage patients. J Clin Neurosci. 2017;46:41-44 pubmed publisher
    ..contributing to poor functional outcome after subarachnoid hemorrhage caused by a ruptured cerebral aneurysm (aSAH)...