Gene Symbol: ARVCF
Description: ARVCF, delta catenin family member
Alias: armadillo repeat protein deleted in velo-cardio-facial syndrome, armadillo repeat gene deleted in velocardiofacial syndrome
Species: human
Products:     ARVCF

Top Publications

  1. Mönkemeyer L, Klaips C, Balchin D, Körner R, Hartl F, Bracher A. Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2. Mol Cell. 2019;74:88-100.e9 pubmed publisher
    ..Hgh1 binding recruits TRiC to the C-terminal eEF2 module and prevents unproductive interactions of domain III, allowing efficient folding of the N-terminal GTPase module. eEF2 folding is completed upon dissociation of TRiC and Hgh1. ..
  2. Cho K, Lee M, Gu D, Munoz W, Ji H, Kloc M, et al. Kazrin, and its binding partners ARVCF- and delta-catenin, are required for Xenopus laevis craniofacial development. Dev Dyn. 2011;240:2601-12 pubmed publisher
    The novel adaptor protein Kazrin associates with multifunctional entities including p120-subfamily members (ARVCF-, delta-, and p0071-catenin)...
  3. Gul I, Hulpiau P, Sanders E, van Roy F, van Hengel J. Armc8 is a evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions. Biosci Rep. 2018;: pubmed publisher
    ..A similar process may occur with respect to plakophilins in desmosomes. Deregulation of desmosomal proteins has been considered to contribute to tumorigenesis. ..
  4. Chhatriwala M, Cipolat S, Sevilla L, Nachat R, Watt F. Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. J Invest Dermatol. 2012;132:1977-87 pubmed publisher
    Kazrin binds to periplakin and ARVCF catenin, and regulates adhesion and differentiation of cultured human keratinocytes...
  5. Hendley A, Provost E, Bailey J, WANG Y, Cleveland M, Blake D, et al. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015;399:41-53 pubmed publisher
    ..of adherens junction proteins E-cadherin, β-catenin, and α-catenin, p120 catenin family members p0071, ARVCF, and δ-catenin remained present at cell membranes in homozygous p120(f/f) pancreases, potentially providing ..
  6. Bujalowski P, Nicholls P, Barral J, Oberhauser A. Thermally-induced structural changes in an armadillo repeat protein suggest a novel thermosensor mechanism in a molecular chaperone. FEBS Lett. 2015;589:123-30 pubmed publisher
    ..We propose that these changes may function to suppress aggregation under stress by allowing binding to a wide variety of aggregation prone loops on its client. ..
  7. Ewald C, Christen M, Watson R, Mihajlovic M, Zhou T, Honegger A, et al. A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein. J Mol Biol. 2015;427:1916-33 pubmed publisher
  8. Straschil U, Talman A, Ferguson D, Bunting K, Xu Z, Bailes E, et al. The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS ONE. 2010;5:e12901 pubmed publisher
  9. Tenhagen M, Klarenbeek S, Braumuller T, Hofmann I, van der Groep P, Ter Hoeve N, et al. p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice. J Mammary Gland Biol Neoplasia. 2016;21:81-88 pubmed
    ..redundancy of p120 family members was observed in mouse ILC development, as expression and localization of ARVCF, p0071 or ?-catenin was unaltered in ILCs from triple-knockout mice...

More Information


  1. Yu H, You X, Li J, Liu H, Meng Z, Xiao L, et al. Genome-Wide Mapping of Growth-Related Quantitative Trait Loci in Orange-Spotted Grouper (Epinephelus coioides) Using Double Digest Restriction-Site Associated DNA Sequencing (ddRADseq). Int J Mol Sci. 2016;17:501 pubmed publisher
    ..Furthermore, we identified 17 genes (fez2, alg3, ece2, arvcf, sla27a4, sgk223, camk2, prrc2b, mchr1, sardh, pappa, syk, tert, wdrcp91, ftz-f1, mate1 and notch1) including ..
  2. Abreu Velez A, Howard M, Velazquez Velez J. Cardiac rhythm and pacemaking abnormalities in patients affected by endemic pemphigus in Colombia may be the result of deposition of autoantibodies, complement, fibrinogen, and other molecules. Heart Rhythm. 2018;15:725-731 pubmed publisher
    ..antibodies to desmoplakins I and II, p0071, armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF), and myocardium-enriched zonula occludens-1-associated protein (MYZAP; Progen Biotechnik) (P <.01)...
  3. Mikula K, Krumwiede L, Plückthun A, Iwai H. Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation. J Biomol NMR. 2018;71:225-235 pubmed publisher
  4. Wang Q, Amato S, Rubitski D, Hayward M, Kormos B, Verhoest P, et al. Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK. J Pharmacol Exp Ther. 2016;356:410-23 pubmed publisher including p120-catenin, δ-catenin, and armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF), each of which is linked to psychiatric or neurologic disorders...
  5. Goh H, Sobota R, Ghadessy F, Nirantar S. Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases. Protein Expr Purif. 2017;129:18-24 pubmed publisher
    ..Here, we show that respectively fusing the interacting ePDZ-b/ARVCF protein-peptide pair to the target protein and a protease enables efficient processing of a minimised sequence ..
  6. Tang W, Tang J, Zhao Y, Qin Y, Jin G, Xu X, et al. Exome-Wide Association Study Identified New Risk Loci for Hirschsprung's Disease. Mol Neurobiol. 2017;54:1777-1785 pubmed publisher
    ..Among these SNPs, the missense variants catechol-O-methyltransferase (COMT) (rs6267) and armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF) (rs80068543) indicated an ectopic expression in colon tissues of HSCR patients...
  7. Boardman J, Walley A, Ball G, Takousis P, Krishnan M, Hughes Carre L, et al. Common genetic variants and risk of brain injury after preterm birth. Pediatrics. 2014;133:e1655-63 pubmed publisher
    ..Carriage of the minor allele at rs2518824 in the armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF) gene, which has been linked to neuronal migration and schizophrenia, and ..
  8. Lindsay E, Goldberg R, Jurecic V, Morrow B, Carlson C, Kucherlapati R, et al. Velo-cardio-facial syndrome: frequency and extent of 22q11 deletions. Am J Med Genet. 1995;57:514-22 pubmed
    ..In one patient we observed a smaller interstitial deletion than that defined by the three loci. The phenotype of this patient was not different from that observed in patients with larger deletions. ..
  9. Abreu Velez A, Yi H, Warfvinge G, Howard M. Autoantibodies to full body vascular cell junctions colocalize with MYZAP, ARVCF, desmoplakins I and II and p0071 in endemic pemphigus in Colombia, South America. Int J Dermatol. 2017;: pubmed publisher
    ..We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF)...
  10. Sim K, Chan W, Woon P, Low H, Lim L, Yang G, et al. ARVCF genetic influences on neurocognitive and neuroanatomical intermediate phenotypes in Chinese patients with schizophrenia. J Clin Psychiatry. 2012;73:320-6 pubmed publisher
    ..These similarities have supported the role of the armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF) as a susceptibility gene in schizophrenia...
  11. Mas S, Bernardo M, Gasso P, Alvarez S, Garcia Rizo C, Bioque M, et al. A functional variant provided further evidence for the association of ARVCF with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1052-9 pubmed publisher
    In a previous linkage disequilibrium mapping study, in the 3' end of ARVCF, we identified one intronic SNP rs165849 and one haplotype block associated with schizophrenia and related disorders...
  12. Sirotkin H, O Donnell H, Dasgupta R, Halford S, St Jore B, Puech A, et al. Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. Genomics. 1997;41:75-83 pubmed
    ..Using two independent gene-isolation procedures, we isolated a new catenin family member termed ARVCF (armadillo repeat gene deleted in VCFS) from the interval deleted in VCFS...
  13. Bonne S, van Hengel J, van Roy F. Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. Genomics. 1998;51:452-4 pubmed
    ..We confirmed the chromosomal localization of the p120(ctn) gene (CTNND1) at 11q11, the ARVCF gene at 22q11, and the delta-catenin/NPRAP gene (CTNND2) at 5p15...
  14. Mariner D, Wang J, Reynolds A. ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes. J Cell Sci. 2000;113 ( Pt 8):1481-90 pubmed
    b>ARVCF is a novel Armadillo repeat domain protein that is closely related to the catenin p120(ctn)...
  15. Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, et al. The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. J Cell Sci. 2000;113 ( Pt 22):4121-35 pubmed
    ..Several members of the armadillo repeat protein family mediate this linkage. We show here that ARVCF, a member of the p120 (ctn) subfamily, is a ligand for the cytoplasmic domain of M-cadherin, and characterize the ..
  16. Sanders A, Rusu I, Duan J, Vander Molen J, Hou C, Schwab S, et al. Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia. Mol Psychiatry. 2005;10:353-65 pubmed
    ..two immediately adjacent genes, thioredoxin reductase 2 and armadillo repeat deleted in velocardiofacial syndrome (ARVCF), using association testing in 136 schizophrenia families...
  17. Kausalya P, Phua D, Hunziker W. Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF. Mol Biol Cell. 2004;15:5503-15 pubmed
    b>ARVCF, an armadillo-repeat protein of the p120(ctn) family, associates with classical cadherins and is present in adherens junctions, but its function is poorly understood...
  18. Michaelovsky E, Frisch A, Leor S, Stein D, Danziger Y, Carel C, et al. Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios. Am J Med Genet B Neuropsychiatr Genet. 2005;139B:45-50 pubmed
    ..a family-based transmission disequilibrium test (TDT) analysis for five SNPs in the COMT and two in the adjacent ARVCF gene...
  19. Mas S, Bernardo M, Parellada E, Garcia Rizo C, Gasso P, Alvarez S, et al. ARVCF single marker and haplotypic association with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:1064-9 pubmed publisher
    ..and rs2239395) in the 3' downstream region of the COMT gene which included a non-dopaminergic candidate gene, the ARVCF (Armadillo like VeloCardio Facial) gene, was associated with the risk of schizophrenia...
  20. Lin D, FitzGerald L, Fu R, Kwon E, Zheng S, Kolb S, et al. Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality. Cancer Epidemiol Biomarkers Prev. 2011;20:1928-36 pubmed publisher
    ..05) as being significantly associated with PCSM, one each in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes...
  21. Sanders A, Duan J, Levinson D, Shi J, He D, Hou C, et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry. 2008;165:497-506 pubmed publisher
    ..candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF)...
  22. Zhang D, Tang N, Liu Y, Wang E. ARVCF expression is significantly correlated with the malignant phenotype of non-small cell lung cancer. Mol Carcinog. 2015;54 Suppl 1:E185-91 pubmed publisher
    Armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) is a member of the p120 catenin (p120ctn) family; it contains nine central Armadillo repeats and binds to the juxtamembrane domain of E-cadherin...
  23. Ulfig N, Chan W. Expression of ARVCF in the human ganglionic eminence during fetal development. Dev Neurosci. 2004;26:38-44 pubmed
    ARVCF (armadillo repeat gene deleted in velocardiofacial syndrome) is a recently characterized member of the catenin p120 (ctn) subfamily of the armadillo repeat proteins...
  24. Walter B, Schlechter T, Hergt M, Berger I, Hofmann I. Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney. Histochem Cell Biol. 2008;130:943-56 pubmed publisher
    The protein ARVCF is a member of the p120 subfamily of armadillo proteins whose members have been described to occur in junction-bound and non-junction-bound forms...
  25. Laura R, Witt A, Held H, Gerstner R, Deshayes K, Koehler M, et al. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem. 2002;277:12906-14 pubmed
    ..most closely resembled the C-terminal PDZ domain-binding motifs of three p120-related catenins: delta-catenin, ARVCF, and p0071 (DSWV-COOH)...
  26. Abreu Velez A, Valencia Yepes C, Upegui Zapata Y, Upegui Quiceno E, Mesa Herrera N, Velazquez Velez J, et al. Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. Clin Exp Dermatol. 2017;42:874-880 pubmed publisher
    ..We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM...
  27. Suzuki G, Harper K, Hiramoto T, Funke B, Lee M, Kang G, et al. Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice. Hum Mol Genet. 2009;18:3914-25 pubmed publisher
    ..2, which includes the genes TXNRD2, COMT and ARVCF, on behaviors in bacterial artificial chromosome (BAC) transgenic (TG) mice...
  28. Abreu Velez A, Yi H, Howard M. Cell junction protein armadillo repeat gene deleted in velo-cardio-facial syndrome is expressed in the skin and colocalizes with autoantibodies of patients affected by a new variant of endemic pemphigus foliaceus in Colombia. Dermatol Pract Concept. 2017;7:3-8 pubmed publisher
    ..presence of patient autoantibodies colocalizing with armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF), a catenin cell junction protein colocalizing with El Bagre-EPF autoantibodies in the heart and within ..
  29. Rappe U, Schlechter T, Aschoff M, Hotz Wagenblatt A, Hofmann I. Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing. J Biol Chem. 2014;289:12421-34 pubmed publisher
    The armadillo repeat protein ARVCF is a component of adherens junctions...
  30. Stenzel N, Fetzer C, Heumann R, Erdmann K. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J Cell Sci. 2009;122:3374-84 pubmed publisher
    ..Our results provide novel insights into the molecular function of FRMPD2 and into the targeting mechanism of peripheral membrane proteins in polarized epithelial cells. ..
  31. Sirotkin H, Morrow B, Saint Jore B, Puech A, Das Gupta R, Patanjali S, et al. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. Genomics. 1997;42:245-51 pubmed
    ..TMVCF is expressed abundantly in human adult lung, heart, and skeletal muscle, and transcripts can be detected at least as early as Day 9 of mouse development. ..