ARNTL

Summary

Gene Symbol: ARNTL
Description: aryl hydrocarbon receptor nuclear translocator like
Alias: BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5, aryl hydrocarbon receptor nuclear translocator-like protein 1, ARNT-like protein 1, brain and muscle, PAS domain containing 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3, basic helix-loop-helix family member e5, basic-helix-loop-helix-PAS orphan MOP3, basic-helix-loop-helix-PAS protein MOP3, brain and muscle ARNT-like 1, class E basic helix-loop-helix protein 5, member of PAS protein 3, member of PAS superfamily 3, testis tissue sperm-binding protein Li 50e
Species: human
Products:     ARNTL

Top Publications

  1. Taniguchi H, Fernandez A, Setien F, Ropero S, Ballestar E, Villanueva A, et al. Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Res. 2009;69:8447-54 pubmed publisher
    ..Herein, we show that the BMAL1 gene, a core component of the circadian clock, is transcriptionally silenced by promoter CpG island ..
  2. Shi J, Wittke Thompson J, Badner J, Hattori E, Potash J, Willour V, et al. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1047-55 pubmed publisher
    ..CRY2, PER1-3, and TIMELESS) in a family collection of 36 trios and 79 quads (Sample I), and 10 circadian genes (ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CSNK1D, CSNK1E, DBP, and NR1D1) in an extended family collection of 70 trios ..
  3. Woon P, Kaisaki P, Braganca J, Bihoreau M, Levy J, Farrall M, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A. 2007;104:14412-7 pubmed
    Many aspects of physiology and behavior follow a circadian rhythm. Brain and muscle Arnt-like protein-1 (BMAL1) is a key component of the mammalian molecular clock, which controls circadian oscillations...
  4. Partonen T, Treutlein J, Alpman A, Frank J, Johansson C, Depner M, et al. Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med. 2007;39:229-38 pubmed
    ..We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression...
  5. Lee J, Lee Y, Lee M, Park E, Kang S, Chung C, et al. Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol. 2008;28:6056-65 pubmed publisher
    Heterodimers of BMAL1 and CLOCK drive rhythmic expression of clock-controlled genes, thereby generating circadian physiology and behavior...
  6. Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008;134:329-40 pubmed publisher
    ..It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for circadian function...
  7. Mansour H, Wood J, Logue T, Chowdari K, Dayal M, Kupfer D, et al. Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav. 2006;5:150-7 pubmed
    ..Modest associations with SNPs at ARNTL (BmaL1) and TIMELESS genes were observed in the BD1 samples...
  8. Mullenders J, Fabius A, Madiredjo M, Bernards R, Beijersbergen R. A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS ONE. 2009;4:e4798 pubmed publisher
    ..Using this approach we have identified three genes, ARNTL, RBCK1 and TNIP1, previously unknown to regulate p53 function...
  9. Lee C, Weaver D, Reppert S. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004;24:584-94 pubmed
    ..We thus propose that the CKIepsilon-binding domain is critical not only for mPER phosphorylation but also for a functioning circadian clock. ..

More Information

Publications100

  1. Ikeda M, Nomura M. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun. 1997;233:258-64 pubmed
    ..Expression of the novel bHLH/PAS factor, brain and muscle Arnt-like protein 1 (BMAL1), was different from that of Arnt and Arnt2, suggesting that BMAL1 has a different function in the CNS and muscle ..
  2. Rutter J, Reick M, Wu L, McKnight S. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science. 2001;293:510-4 pubmed
    Clock:BMAL1 and NPAS2:BMAL1 are heterodimeric transcription factors that control gene expression as a function of the light-dark cycle...
  3. Griffin E, Staknis D, Weitz C. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science. 1999;286:768-71 pubmed
    ..Mammalian CRY1 and CRY2 are here shown to act as light-independent inhibitors of CLOCK-BMAL1, the activator driving Per1 transcription...
  4. Jin X, Shearman L, Weaver D, Zylka M, de Vries G, Reppert S. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 1999;96:57-68 pubmed
    ..A core clock mechanism in mouse SCN appears to involve a transcriptional feedback loop in which CLOCK and BMAL1 are positive regulators and three mPeriod (mPer) genes are involved in negative feedback...
  5. Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, et al. Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Biochem Biophys Res Commun. 1998;248:789-94 pubmed
    ..We also showed that Arnt3 contained an activation domain at the C-terminal region and a repression domain between the PAS-A and PAS-B regions. ..
  6. Gekakis N, Staknis D, Nguyen H, Davis F, Wilsbacher L, King D, et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 1998;280:1564-9 pubmed
    ..Potential partners of CLOCK were isolated in a two-hybrid screen, and one, BMAL1, was coexpressed with CLOCK and PER1 at known circadian clock sites in brain and retina...
  7. Englund A, Kovanen L, Saarikoski S, Haukka J, Reunanen A, Aromaa A, et al. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. J Circadian Rhythms. 2009;7:5 pubmed publisher
    ..049). Our findings support the view that relevant relationships between circadian clocks and the metabolic syndrome in humans exist. ..
  8. Lavebratt C, Sjöholm L, Partonen T, Schalling M, Forsell Y. PER2 variantion is associated with depression vulnerability. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:570-581 pubmed publisher
    ..Polymorphisms in the circadian genes NPAS2, ARNTL, and RORA were also suggested to contribute to depression vulnerability...
  9. Archer S, Viola A, Kyriakopoulou V, von Schantz M, Dijk D. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. Sleep. 2008;31:608-17 pubmed
    ..Circadian rhythm phase and amplitude of plasma melatonin, cortisol, and BMAL1, PER2, and PER3 expression were assessed during a constant routine...
  10. Hogenesch J, Gu Y, Jain S, Bradfield C. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998;95:5474-9 pubmed
    We report that MOP3 is a general dimerization partner for a subset of the basic-helix-loop-helix (bHLH)-PER-ARNT-SIM (PAS) superfamily of transcriptional regulators...
  11. Nakashima A, Kawamoto T, Honda K, Ueshima T, Noshiro M, Iwata T, et al. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 2008;28:4080-92 pubmed publisher
    DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear...
  12. Fukuya H, Emoto N, Nonaka H, Yagita K, Okamura H, Yokoyama M. Circadian expression of clock genes in human peripheral leukocytes. Biochem Biophys Res Commun. 2007;354:924-8 pubmed
    ..of clock genes in human leukocytes and found that Per1 mRNA exhibits a robust circadian expression while Per2 and Bmal1 mRNA showed weak rhythm...
  13. Kondratov R, Kondratova A, Lee C, Gorbacheva V, Chernov M, Antoch M. Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle. 2006;5:890-5 pubmed
    Mammalian CLOCK(NPAS2), BMAL1 and CRYPTOCHROMEs are core components of the circadian oscillatory mechanism. The active CLOCK/BMAL1 or NPAS2/BMAL1 complexes regulate expression of numerous genes including two Cryptochromes...
  14. Nievergelt C, Kripke D, Barrett T, Burg E, Remick R, Sadovnick A, et al. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:234-41 pubmed
    ..We have assessed evidence for linkage and association involving polymorphisms in 10 circadian clock genes (ARNTL, CLOCK, CRY2, CSNK1epsilon, DBP, GSK3beta, NPAS2, PER1, PER2, and PER3) to BPAD...
  15. Sato T, Yamada R, Ukai H, Baggs J, Miraglia L, Kobayashi T, et al. Feedback repression is required for mammalian circadian clock function. Nat Genet. 2006;38:312-9 pubmed
    ..genetic screen in mammalian cells to identify mutants of the circadian transcriptional activators CLOCK and BMAL1, which were uncoupled from CRYPTOCHROME (CRY)-mediated transcriptional repression...
  16. Curtis A, Seo S, Westgate E, Rudic R, Smyth E, Chakravarti D, et al. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004;279:7091-7 pubmed
    ..Furthermore, Cry2 mediated repression of NPAS2:BMAL1 is overcome by overexpression of p300 in transactivation assays...
  17. McNamara P, Seo S, Rudic R, Sehgal A, Chakravarti D, Fitzgerald G. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell. 2001;105:877-89 pubmed
    ..These interactions negatively regulate CLOCK/MOP4:BMAL1-mediated transcriptional activation of clock gene expression in vascular cells...
  18. Lai K, Kweon S, Chi F, Hwang E, Kabe Y, Higashiyama R, et al. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017;152:1477-1491 pubmed publisher
    ..Genetic disruption of Scd and pharmacologic inhibitors of SCD reduced HSC activation and TIC self-renewal and attenuated liver fibrosis and tumorigenesis in mice...
  19. Gariup M, González A, Lázaro L, Torres F, Serra Pagès C, Morer A. IL-8 and the innate immunity as biomarkers in acute child and adolescent psychopathology. Psychoneuroendocrinology. 2015;62:233-42 pubmed publisher
    ..Patients with a diagnosis of Affective, Anxiety, Adjustment, Psychotic, Obsessive-Compulsive, Tic or Tourette Disorders were consecutively recruited from our clinic between June 2010 and February 2012...
  20. Altinoz M, Ince B. Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects. Int J Dev Neurosci. 2017;61:73-85 pubmed publisher
    ..Cooccurences of mental disorders (mainly bipolar disorder (BD) and tic disorders) with ?- or ?-thalassemia trait or erythrocytosis were witnessed, which may be due to peripheral or ..
  21. Magni M, Buscemi G, Zannini L. Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology. Mutat Res. 2018;776:1-9 pubmed publisher
    ..Moreover, promoting Rev-erbα protein stability and repressing BMAL1 and CLOCK expression, it was reported to modulate the circadian rhythm...
  22. Han M, Xie M, Han J, Yuan D, Yang T, Xie Y. Development and validation of a rapid, selective, and sensitive LC-MS/MS method for simultaneous determination of D- and L-amino acids in human serum: application to the study of hepatocellular carcinoma. Anal Bioanal Chem. 2018;410:2517-2531 pubmed publisher
    ..AA amino acid, HCC hepatocellular carcinoma, LC liquid chromatography, MS/MS tandem mass spectrometry, NC normal control, TIC total ion chromatogram.
  23. Engin A. Circadian Rhythms in Diet-Induced Obesity. Adv Exp Med Biol. 2017;960:19-52 pubmed publisher
    ..proliferator-activated receptor (PPAR) alpha increases the transcriptional level of brain and muscle ARNT-like 1 (BMAL1) in obese subjects...
  24. Huisman S, Ahmadi A, Ijzermans J, Verhoef C, van der Horst G, de Bruin R. Disruption of clock gene expression in human colorectal liver metastases. Tumour Biol. 2016;37:13973-13981 pubmed
    ..real-time polymerase chain reaction (qRT-PCR) was used to measure the expression of 10 clock genes: CLOCK, BMAL1, PER1, PER2, PER3, CRY1, CRY2, CSNK1E, TIM, TIPIN, and 2 clock-controlled genes: Cyclin-D1, and WEE1...
  25. Ikarashi R, Akechi H, Kanda Y, Ahmad A, Takeuchi K, Morioka E, et al. Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca2+ signaling in human retinal pigment epithelial cells. Sci Rep. 2017;7:44175 pubmed publisher
    ..from human retinal pigmental epithelium, which stably co-expressed reporters for molecular clock oscillations (Bmal1-luciferase) and intracellular Ca2+ concentrations (YC3.6)...
  26. Keesler J. Trauma-informed Day Services for Individuals with Intellectual/Developmental Disabilities: Exploring Staff Understanding and Perception within an Innovative Programme. J Appl Res Intellect Disabil. 2016;29:481-92 pubmed publisher
    Trauma-informed care (TIC) is a systems-level philosophy of service delivery which integrates choice, collaboration, empowerment, safety and trust to create an organizational culture sensitive to trauma...
  27. Kim H, Lee H, Cho C, Kang S, Yoon H, Park Y, et al. Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior. Chronobiol Int. 2015;32:785-91 pubmed publisher
    ..In this study, we investigated polymorphisms in the CLOCK, ARNTL, and NPAS2 genes in relation to seasonal variation in 507 healthy young adults...
  28. Janjić K, Kurzmann C, Moritz A, Agis H. Expression of circadian core clock genes in fibroblasts of human gingiva and periodontal ligament is modulated by L-Mimosine and hypoxia in monolayer and spheroid cultures. Arch Oral Biol. 2017;79:95-99 pubmed publisher
    ..and quantitative PCR were performed to assess the impact on mRNA levels of the circadian core clock genes Clock, Bmal1, Cry1, Cry2, Per1, Per2, and Per3...
  29. Nakata T, Matsuura N, Kaji H, Shimizu M, Fukushima R, Machida N, et al. Sequential radial and circumferential strain and oxidative stress assessment in dogs with tachycardia-induced cardiac dysfunction. Int J Cardiovasc Imaging. 2016;32:583-91 pubmed publisher
    ..to detect subtle regional changes in the LV contractility during development of tachycardia-induced cardiomyopathy (TIC) to heart failure in awake dog; (2) oxidized glutathione (GSSG) and reduced glutathione (GSH) levels are associated ..
  30. Aryal R, Kwak P, Tamayo A, Gebert M, Chiu P, Walz T, et al. Macromolecular Assemblies of the Mammalian Circadian Clock. Mol Cell. 2017;67:770-782.e6 pubmed publisher
    ..9-MDa repressor assembly that quantitatively incorporates its CLOCK-BMAL1 transcription factor target. Prior to incorporation, CLOCK-BMAL1 exists in an ?750-kDa complex...
  31. Sjöholm L, Kovanen L, Saarikoski S, Schalling M, Lavebratt C, Partonen T. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. J Circadian Rhythms. 2010;8:1 pubmed publisher
    ..Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD. ..
  32. Homberg J, Kyzar E, Nguyen M, Norton W, Pittman J, Poudel M, et al. Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. Neurosci Biobehav Rev. 2016;65:292-312 pubmed publisher
    ..common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder...
  33. Narasimamurthy R, Virshup D. A Flick of the Tail Keeps the Circadian Clock in Line. Mol Cell. 2017;66:437-438 pubmed publisher
    ..In this issue of Molecular Cell, Gustafson et al. (2017) report an additional requirement for accurate timekeeping, a cis/trans conformational flicker in the transcriptional activation domain of the core clock protein BMAL1.
  34. Besing R, Rogers C, Paul J, Hablitz L, Johnson R, McMahon L, et al. GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. Hippocampus. 2017;27:890-898 pubmed publisher
    ..Chronic activation of both GSK3 isoforms in transgenic mice (GSK3-KI mice) diminished rhythmic BMAL1 expression...
  35. Liu C, Liu Y, Xu X, Wu H, Xie H, Chen L, et al. Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions. Exp Cell Res. 2015;330:123-34 pubmed publisher
    Cancer stem cell (CSC) or tumor initiating cell (TIC) plays an important role in tumor progression and metastasis. Biophysical forces in tumor microenvironment have an important effect on tumor formation and development...
  36. Karantanos T, Theodoropoulos G, Gazouli M, Vaiopoulou A, Karantanou C, Lymberi M, et al. Expression of clock genes in patients with colorectal cancer. Int J Biol Markers. 2013;28:280-5 pubmed publisher
    ..Quantitative real-time PCR was used to examine the expression levels of CLOCK1, BMAL1, PER1, PER2 and PER3 genes in all the samples. In the cancerous tissues CLOCK1 (p<0.0001) and BMAL1 (p<0...
  37. Khalil K, Sherif E, Nabawy A, Abdo H, Marzouk W, Alharbi H. Titanium Carbide Nanofibers-Reinforced Aluminum Compacts, a New Strategy to Enhance Mechanical Properties. Materials (Basel). 2016;9: pubmed publisher
    b>TiC nanofibers reinforced Al matrix composites were produced by High Frequency Induction Heat Sintering (HFIHS)...
  38. Seragni G, Chiappedi M, Bettinardi B, Zibordi F, Colombo T, Reina C, et al. Habit reversal training in children and adolescents with chronic tic disorders: an Italian randomized, single-blind pilot study. Minerva Pediatr. 2018;70:5-11 pubmed publisher
    ..possibility to apply habit reversal training (HRT) in Italy and to evaluate the effectiveness of HRT in reducing tic severity compared with the "usual care" (UC) in Italian children and adolescents with Tourette Syndrome...
  39. Abramovitch A, Reese H, Woods D, Peterson A, Deckersbach T, Piacentini J, et al. Psychometric Properties of a Self-Report Instrument for the Assessment of Tic Severity in Adults With Tic Disorders. Behav Ther. 2015;46:786-96 pubmed publisher
    The gold-standard measure of tic severity in tic disorders (TD), the Yale Global Tic Severity Scale (YGTSS), is a semistructured clinician-administered interview that can be time consuming and requires highly trained interviewers...
  40. Smith J, Fahrenkrug J, Jørgensen H, Christoffersen C, Goetze J. Diurnal gene expression of lipolytic natriuretic peptide receptors in white adipose tissue. Endocr Connect. 2015;4:206-14 pubmed publisher
    ..Tissue mRNA contents of NPRs - NPR-A and NPR-C, the clock genes Per1 and Bmal1, and transcripts involved in lipid metabolism were quantified at 4-h intervals: in the diurnal study, mice were ..
  41. Snelling S, Forster A, Mukherjee S, Price A, Poulsen R. The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis. Chronobiol Int. 2016;33:574-9 pubmed publisher
    ..Following serum shock, PER2 expression was significantly higher, whereas BMAL1 expression was significantly lower, in osteoarthritic chondrocytes...
  42. Patel S, Velingkaar N, Makwana K, Chaudhari A, Kondratov R. Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms. Sci Rep. 2016;6:25970 pubmed publisher
    ..CR-dependent effects on some clock gene expression were impaired in the liver of mice deficient for BMAL1, suggesting importance of this transcriptional factor for the transcriptional reprogramming of the clock, however, ..
  43. Moraes M, Mezzalira N, de Assis L, Menaker M, Güler A, Castrucci A. TRPV1 participates in the activation of clock molecular machinery in the brown adipose tissue in response to light-dark cycle. Biochim Biophys Acta Mol Cell Res. 2017;1864:324-335 pubmed publisher
    ..tissue (BAT), TrpV1 oscillated with higher expression at scotophase, Per1 and Per2 showed the same profile, and Bmal1 transcript only oscillated in DD...
  44. Coghill D, Banaschewski T, Nagy P, Otero I, Soutullo C, Yan B, et al. Long-Term Safety and Efficacy of Lisdexamfetamine Dimesylate in Children and Adolescents with ADHD: A Phase IV, 2-Year, Open-Label Study in Europe. CNS Drugs. 2017;31:625-638 pubmed publisher
    ..2%), insomnia (13.1%), initial insomnia (8.9%), irritability (8.6%), nausea (6.7%), headache (5.7%), and tic (5.1%)...
  45. Yaniv A, Benaroya Milshtein N, Steinberg T, Ruhrman D, Apter A, Lavidor M. Executive control development in Tourette syndrome and its role in tic reduction. Psychiatry Res. 2018;262:527-535 pubmed publisher
    ..Recent findings point to a possible role of executive functions system development in the tic reduction observed with age...
  46. Chen Z, Liu Y, Yao L, Guo S, Gao Y, Zhu P. The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1. J Biol Chem. 2018;293:7982-7992 pubmed publisher
    ..MARCKS) and MARCKS-like 1 (MARCKSL1), whose expression levels were increased during liver tumorigenesis and liver TIC self-renewal...
  47. Pappa K, Gazouli M, Anastasiou E, Iliodromiti Z, Antsaklis A, Anagnou N. The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus. Diabetes Res Clin Pract. 2013;99:151-7 pubmed publisher
    Recently a relationship between circadian clock function and the risk for type 2 diabetes (T2D) has been shown. BMAL1 is a key component of the mammalian molecular clock...
  48. Suyama K, Silagi E, Choi H, Sakabe K, Mochida J, Shapiro I, et al. Circadian factors BMAL1 and ROR? control HIF-1? transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. 2016;7:23056-71 pubmed publisher
    b>BMAL1 and ROR? are major regulators of the circadian molecular oscillator...
  49. Mazzoccoli G, Rubino R, Tiberio C, Giuliani F, Vinciguerra M, Oben J, et al. Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation. Chronobiol Int. 2016;33:181-90 pubmed publisher
    ..in mouse liver, and a significant 24-hour rhythmic component was found for five clock genes in the HepG2 cells (Bmal1, Cry1, Per1, Per2, NR1D1) and for six clock genes in the mouse liver (Bmal1, Clock, Cry1, Per1, Per2, NR1D1)...
  50. Ward S, Fernando S, Hou T, Duffield G. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010;285:38987-9000 pubmed publisher
    ..ID2 can suppress the transactivation potential of the positive elements of the clock, CLOCK-BMAL1, on mPer1 and clock-controlled gene (CCG) activity...
  51. Wolff N, Luehr I, Sender J, Ehrlich S, Schmidt Samoa C, Dechent P, et al. A DTI study on the corpus callosum of treatment-naïve boys with 'pure' Tourette syndrome. Psychiatry Res Neuroimaging. 2016;247:1-8 pubmed publisher
    ..Moreover, a negative correlation between AD and the Yale Global Tic Severity Scale total score was observed...
  52. Bhargava A, Herzel H, Ananthasubramaniam B. Mining for novel candidate clock genes in the circadian regulatory network. BMC Syst Biol. 2015;9:78 pubmed publisher
    ..genes expressed in a circadian manner in multiple tissues with regulation driven mainly by transcription factors BMAL1 and REV-ERB α,β. Moreover, peak transcription of candidate genes was remarkably consistent across tissues...
  53. Drury H, Wilkinson V, Robertson M, Channon S. Self-reported emotion regulation in adults with Tourette's syndrome. Psychiatry Res. 2016;245:157-163 pubmed publisher
    ..Further work is needed to examine potential factors that may influence emotion regulation in TS, including increased emotional reactivity or expertise in applying strategies to suppress tic symptoms.
  54. Huang Z, Li Z, Su Y, Zhu Y, Zeng W, Chen G, et al. Continuous Production of Isomalto-oligosaccharides by Thermo-inactivated Cells of Aspergillus niger J2 with Coarse Perlite as an Immobilizing Material. Appl Biochem Biotechnol. 2018;185:1088-1099 pubmed publisher
    ..The PBR was prepared by mixing the thermo-inactivated cells (TIC) from Aspergillus niger J2 strain with the coarse perlite, then the mixture was put into an overpressure-resistant ..
  55. Barendregt A, van Gulik E, Lavini C, Nusman C, van den Berg J, Schonenberg Meinema D, et al. Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents. Eur Radiol. 2017;27:4889-4899 pubmed publisher
    ..enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs...
  56. Kavcic P, Rojc B, Dolenc Groselj L, Claustrat B, Fujs K, Poljak M. The impact of sleep deprivation and nighttime light exposure on clock gene expression in humans. Croat Med J. 2011;52:594-603 pubmed
    ..Our results suggest that 40-hour acute sleep deprivation under light conditions may affect the expression of hPer2 in PBMCs.. ..
  57. He Q, Jin F, Li Y, Wu W, Long J, Luo X, et al. Prognostic significance of downregulated BMAL1 and upregulated Ki-67 proteins in nasopharyngeal carcinoma. Chronobiol Int. 2018;35:348-357 pubmed publisher
    This study assessed the prognostic value of BMAL1 and Ki-67 expression in patients with nasopharyngeal carcinoma...
  58. Wang L, Wang Q, Huang J, Li W, Chen G, Yang Y. Interface and interaction of graphene layers on SiC(0001[combining macron]) covered with TiC(111) intercalation. Phys Chem Chem Phys. 2017;19:26765-26775 pubmed publisher
    It is important to understand the interface and interaction between the graphene layer, titanium carbide [TiC(111)] interlayer, and silicon carbide [SiC(0001[combining macron])] substrates in epitaxial growth of graphene on silicon ..
  59. Yuan S, Qiao T, Qiang J, Cai S, Li R. The value of DCE-MRI in assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas. J Ovarian Res. 2017;10:65 pubmed publisher
    ..to evaluate the morphology and perfusion features of the tumors, including the time-signal intensity curve (TIC), volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space ..
  60. Lavtar P, Rudolf G, Maver A, Hodžić A, Starčević Čizmarević N, Živković M, et al. Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. PLoS ONE. 2018;13:e0190601 pubmed publisher
    ..of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis...
  61. Wang S, Zhang X, Zhang Y, Mao J, Yang Z. First-principles investigation of H2S adsorption and dissociation on titanium carbide surfaces. Phys Chem Chem Phys. 2017;19:27116-27122 pubmed publisher
    The adsorption and dissociation reactions of H2S on TiC(001) are investigated using first-principles density functional theory calculations...
  62. Groth C, Debes N, Skov L. Phenotype Development in Adolescents With Tourette Syndrome: A Large Clinical Longitudinal Study. J Child Neurol. 2017;32:1047-1057 pubmed publisher
    ..This study aimed to describe the development of phenotypes in TS and tic-related impairment in a large longitudinal study of 226 children and adolescents followed up after 6 years...
  63. Giannetti A, Matergi M, Biscontri M, Franci L. Contrast-enhanced ultrasonography in clinical practice in Crohn's disease: feasibility of destruction/replenishment method and software analysis. J Ultrasound. 2017;20:309-319 pubmed publisher
    ..the feasibility in the clinical practice of CEUS destruction/replenishment method and time intensity curve (TIC) analysis using the available software in patients with Crohn's disease...
  64. Momma T, Okayama H, Saitou M, Sugeno H, Yoshimoto N, Takebayashi Y, et al. Expression of circadian clock genes in human colorectal adenoma and carcinoma. Oncol Lett. 2017;14:5319-5325 pubmed publisher
    ..circadian locomoter output cycles protein kaput (Clock), brain and muscle ARNT-like protein 1 (Bmal1) and casein kinase 1? (CK1?) were retrospectively examined in 51 cases of colorectal carcinoma and 10 ..
  65. Baos S, Underwood W, Culliford L, Reeves B, Rogers C, Bowles R, et al. Platelet inhibition during ticagrelor monotherapy versus ticagrelor plus aspirin in patients with coronary artery disease (TEMPLATE study): study protocol for a randomised controlled trial. Trials. 2017;18:529 pubmed publisher
    ..The P2Y12 blocker ticagrelor (TIC) has greater antiplatelet effect than the previously used members of this class, such as clopidogrel...
  66. Li S, Zhai J, Liu J, Hong Y, Zhao W, Zhao A, et al. BMAL1 facilitates trophoblast migration and invasion via SP1-DNMT1/DAB2IP pathway in recurrent spontaneous abortion. Oncotarget. 2017;8:89451-89464 pubmed publisher
    ..Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been reported to be ..
  67. Tian W, Zhao Q, Zhao C, Qiu F, Jiang Q. The Dry Sliding Wear Properties of Nano-Sized TiCp/Al-Cu Composites at Elevated Temperatures. Materials (Basel). 2017;10: pubmed publisher
    ..Here the Al-Cu composites reinforced with nano-sized TiCp were fabricated...
  68. Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, et al. Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 2011;25:1439-46 pubmed publisher
    ..genes: Period1 (Per1), Period2 (Per2), Period3 (Per3), Cryptochrome1 (Cry1), Cryptochrome2 (Cry2), Clock, Bmal1 and Casein Kinase I ? (CKI?)...
  69. Giordano S, Spiezia L, Campello E, Simioni P. The current understanding of trauma-induced coagulopathy (TIC): a focused review on pathophysiology. Intern Emerg Med. 2017;12:981-991 pubmed publisher
    ..The importance of an early trauma-induced coagulopathy (TIC) diagnosis has led physicians to increase the efforts to better understand the pathophysiological alterations ..
  70. Ogihara Y, Ashizawa K, Hayashi H, Nagayasu T, Hayashi T, Honda S, et al. Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. Acta Radiol. 2018;59:72-80 pubmed publisher
    ..images, post-contrast enhancement pattern on T1-weighted (T1W) images, and the pattern of the time intensity curve (TIC) on contrast-enhanced dynamic studies were evaluated...
  71. Müller Vahl K, Loeber G, Kotsiari A, Müller Engling L, Frieling H. Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene. J Psychiatr Res. 2017;86:1-8 pubmed publisher
    ..patients with TS showed significantly elevated methylation level of the DRD2 gene that positively correlated with tic severity. In contrast, DAT methylation was lower in more severely affected patients...
  72. Jonjic N, Rajković Molek K, Seili Bekafigo I, Grbac Ivanković S, Girotto N, Jurisic D, et al. Predictive Value of Intraoperative Sentinel Lymph Node Imprint Cytology Analysis for Metastasis in Patients with Melanoma. Acta Dermatovenerol Croat. 2017;25:99-106 pubmed
    ..Each lymph node was cut in half; touch imprint cytology (TIC) preparations of all cut surfaces were performed and stained according to a modified May-Grünwald-Giemsa method...
  73. Eide E, Vielhaber E, Hinz W, Virshup D. The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem. 2002;277:17248-54 pubmed
    ..We find that CRY1 and BMAL1 are phosphoproteins in cultured cells...
  74. Baird A, Coogan A, Siddiqui A, Donev R, Thome J. Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatry. 2012;17:988-95 pubmed publisher
    ..of gross motor patterns, by self-sampling of oral mucosa for assessment of rhythmic expression of the clock genes BMAL1 and PER2, and by estimation of salivary cortisol and melatonin levels...
  75. Cedernaes J, Osler M, Voisin S, Broman J, Vogel H, Dickson S, et al. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol Metab. 2015;100:E1255-61 pubmed publisher
    ..and subcutaneous adipose tissue biopsies for DNA methylation and gene expression analyses of core clock genes (BMAL1, CLOCK, CRY1, PER1)...
  76. Chen Q, Peng X, Huang C, Hu X, Zhang X. Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population. Genet Mol Res. 2015;14:18515-22 pubmed publisher
    In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD)...
  77. Chen D, Li Y, Yu Y, Zhou T, Liu C, Fei E, et al. Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells. Acta Pharmacol Sin. 2018;39:597-606 pubmed publisher
    ..Furthermore, full-length DCNP1 but not the mutants interacted with and repressed the transcriptional activity of BMAL1, a transcription factor that transactivates Nat through the E-box motif...
  78. Yoshida K, Nakai A, Kaneshiro K, Hashimoto N, Suzuki K, Uchida K, et al. TNF-α induces expression of the circadian clock gene Bmal1 via dual calcium-dependent pathways in rheumatoid synovial cells. Biochem Biophys Res Commun. 2018;495:1675-1680 pubmed publisher
    ..We tried to determine the mechanism involved in over-expression of Bmal1, induced by TNF-α, in primary cultured rheumatoid synovial cells...
  79. Kosaki R, Horikawa R, Fujii E, Kosaki K. Biallelic mutations in LARS2 can cause Perrault syndrome type 2 with neurologic symptoms. Am J Med Genet A. 2018;176:404-408 pubmed publisher
    ..pervasive developmental disorder at 8 years, with repetitive behavior, insistence on sameness, attention deficit, tic, irritability, and an ataxic gait...
  80. Markowska M, Majewski P, Skwarło Sońta K. Avian biological clock - Immune system relationship. Dev Comp Immunol. 2017;66:130-138 pubmed publisher
    ..Interleukin 6 and interleukin 18 seem to be the immune mediators influencing the pineal gland, directly inhibiting Aanat gene transcription and modulating expression of the clock genes Bmal1 and Per3, which in turn regulate Aanat.
  81. Quintela T, Albuquerque T, Lundkvist G, Carmine Belin A, Talhada D, Goncalves I, et al. The choroid plexus harbors a circadian oscillator modulated by estrogens. Chronobiol Int. 2018;35:270-279 pubmed publisher
    ..Furthermore, we demonstrate that estrogen declines following ovariectomy modulates the daily rhythm expression of Bmal1, Per1 and Per2 in female rat CP, corroborating data obtained in experiments where rat CP epithelial cell (CPEC) ..
  82. Brager A, Heemstra L, Bhambra R, Ehlen J, Esser K, Paul K, et al. Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock. Biochimie. 2017;132:161-165 pubmed publisher
    Brain and muscle-ARNT-like factor (Bmal1/BMAL1) is an essential transcriptional/translational factor of circadian clocks. Loss of function of Bmal1/BMAL1 is highly disruptive to physiological and behavioral processes...
  83. Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C. Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Transl Psychiatry. 2017;7:e1013 pubmed publisher
    b>Tic disorders affect ~5% of the population and are frequently comorbid with obsessive-compulsive disorder, autism, and attention deficit disorder...
  84. Sun L, Chen G, Zhou Y, Zhang L, Jin Z, Liu W, et al. Clinical significance of MSKCC nomogram on guiding the application of touch imprint cytology and frozen section in intraoperative assessment of breast sentinel lymph nodes. Oncotarget. 2017;8:78105-78112 pubmed publisher
    ..and detection of sentinel lymph node (SLN) status include frozen section (FS) and touch imprint cytology (TIC)...
  85. House C, Jordan E, Hernandez L, Ozaki M, James J, Kim M, et al. NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells. Cancer Res. 2017;77:6927-6940 pubmed publisher
    Understanding the mechanisms supporting tumor-initiating cells (TIC) is vital to combat advanced-stage recurrent cancers...
  86. Loza C, Shute J, Principe J, Okun M, Gunduz A. A marked point process approach for identifying neural correlates of tics in Tourette Syndrome. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:4375-4378 pubmed publisher
    ..We utilize the learned features in the alpha and beta bands to assess correlations to tic events in patients with Tourette Syndrome (TS)...
  87. Amare A, Schubert K, Baune B. Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry. EPMA J. 2017;8:211-227 pubmed publisher
    ..i>TPH, DRD1, FYN, INPP1, CREB1, BDNF, GSK3?, ARNTL, TIM, DPB, NR3C1, BCR, XBP1, and CACNG2...
  88. Utge S, Soronen P, Loukola A, Kronholm E, Ollila H, Pirkola S, et al. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS ONE. 2010;5:e9259 pubmed publisher
    ..also some evidence of interaction between TIMELESS and PER1 in females to D+FAT+ as well as between TIMELESS and ARNTL, RORA or NR1D1 in males to D+EMA+...
  89. Agarwal N, Mishra I, Komal R, Rani S, Kumar V. Circannual testis and moult cycles persist under photoperiods that disrupt circadian activity and clock gene cycles in spotted munia. J Exp Biol. 2017;220:4162-4168 pubmed publisher
    ..We measured the behavioural activity pattern of the birds and 24?h mRNA oscillations of circadian clock genes (bmal1, clock, per2, cry1, cry2) in the hypothalamus, the putative site of seasonal ..
  90. Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. elife. 2016;5: pubmed publisher
    ..Through expanded architectural comparisons between these complexes and HIF-1?-ARNT, HIF-2?-ARNT and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of ..
  91. Mataix Cols D, Frans E, Pérez Vigil A, Kuja Halkola R, Gromark C, Isomura K, et al. A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders. Mol Psychiatry. 2018;23:1652-1658 pubmed publisher
    The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain...