Arkadia

Summary

Gene Symbol: Arkadia
Description: ring finger protein 111
Alias: ARK, hRNF111, E3 ubiquitin-protein ligase Arkadia, Arkadia, RING-type E3 ubiquitin transferase Arkadia
Species: human
Products:     Arkadia

Top Publications

  1. Niederlander C, Walsh J, Episkopou V, Jones C. Arkadia enhances nodal-related signalling to induce mesendoderm. Nature. 2001;410:830-4 pubmed
    ..Here we show that the nuclear protein Arkadia specifically potentiates the mesendoderm-inducing activity of a subset of TGF-beta family members...
  2. Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K. Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling. J Biochem. 2010;148:733-41 pubmed publisher
    b>Arkadia is a positive regulator of transforming growth factor (TGF)-? signalling that induces ubiquitin-dependent degradation of several inhibitory proteins of TGF-? signalling through its C-terminal RING domain...
  3. Episkopou V, Arkell R, Timmons P, Walsh J, Andrew R, Swan D. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001;410:825-30 pubmed
    ..Here we describe a recessive lethal mutation, arkadia, generated using gene-trap mutagenesis...
  4. Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, et al. Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J. 2003;22:6458-70 pubmed
    b>Arkadia was originally identified as a protein that enhances signalling activity of Nodal and induces mammalian nodes during early embryogenesis; however, the mechanisms by which Arkadia affects transforming growth factor-beta (TGF-beta) ..
  5. Liu W, Rui H, Wang J, Lin S, He Y, Chen M, et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 2006;25:1646-58 pubmed
    ..Axin activates TGF-beta signaling by forming a multimeric complex consisting of Smad7 and ubiquitin E3 ligase Arkadia. Axin depends on Arkadia to facilitate TGF-beta signaling, as their small interfering RNAs reciprocally abolished ..
  6. Nagano Y, Mavrakis K, Lee K, Fujii T, Koinuma D, Sase H, et al. Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. J Biol Chem. 2007;282:20492-501 pubmed
    ..We previously found that Arkadia is a positive regulator of TGF-beta signaling that induces ubiquitin-dependent degradation of Smad7 through its C-..
  7. Le Scolan E, Zhu Q, Wang L, Bandyopadhyay A, Javelaud D, Mauviel A, et al. Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res. 2008;68:3277-85 pubmed publisher
    ..On TGF-beta treatment, the E3 ubiquitin ligase Arkadia mediates degradation of Ski in a Smad-dependent manner...
  8. Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T. Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts. Bone. 2009;44:53-60 pubmed publisher
    ..In this study, we examined the roles of Arkadia, an E3 ubiquitin ligase, in Myostatin/TGF-beta signaling and the regulation of myoblast differentiation...
  9. Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill C. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol. 2007;27:6068-83 pubmed
    ..RNA library, using TGF-beta induction of a Smad3/Smad4-dependent luciferase reporter as a readout, revealed that Arkadia is an E3 ubiquitin ligase that is absolutely required for this TGF-beta response...

More Information

Publications117 found, 100 shown here

  1. Nagano Y, Koinuma D, Miyazawa K, Miyazono K. Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. J Biochem. 2010;147:545-54 pubmed publisher
    b>Arkadia is a positive regulator of transforming growth factor-beta (TGF-beta) signalling, which induces ubiquitylation and proteasome-dependent degradation of negative regulators of the TGF-beta signalling pathway, i.e...
  2. Poulsen S, Hansen R, Wagner S, van Cuijk L, van Belle G, Streicher W, et al. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. J Cell Biol. 2013;201:797-807 pubmed publisher
    ..Only a single mammalian STUbL, RNF4, has been identified. We show that human RNF111/Arkadia is a new STUbL, which used three adjacent SIMs for specific recognition of poly-SUMO2/3 chains, and used Ubc13-..
  3. Hardwicke T, Ioannidis J. Populating the Data Ark: An attempt to retrieve, preserve, and liberate data from the most highly-cited psychology and psychiatry articles. PLoS ONE. 2018;13:e0201856 pubmed publisher
    ..Therefore, we launched an initiative-the Data Ark-to examine whether we could retrospectively enhance the preservation and accessibility of important scientific data...
  4. Pahlitzsch T, Pahlitzsch M, Sumarni U, Pahlitzsch M. [LenSx® femto-LASIK, FEMTO LDV Z4® femto-LASIK, and PRK : Comparison of refractive results and an analysis of complications]. Ophthalmologe. 2018;115:928-940 pubmed publisher
    ..distance subjective visual acuity, corneal topography (Pentacam® HR; Wetzlar, Germany), and objective astigmatism (ARK-760A Refractometer ; Nidek, Fremont, CA, USA) were measured preoperatively, and 1 day, 1 week, 1 month, and 3 ..
  5. Xin L, Huang B, Zhang H, Li C, Bai C, Wang C. OsHV-1 infection leads to mollusc tissue lesion and iron redistribution, revealing a strategy of iron limitation against pathogen. Metallomics. 2019;11:822-832 pubmed publisher
    ..Firstly, ark clams, Scapharca broughtonii, were experimentally infected with OsHV-1, and serious hyperaemia in hepatopancreases ..
  6. Kawaguchi A, Nita M, Ishii T, Watanabe M, Noutoshi Y. Biological control agent Rhizobium (=Agrobacterium) vitis strain ARK-1 suppresses expression of the essential and non-essential vir genes of tumorigenic R. vitis. BMC Res Notes. 2019;12:1 pubmed publisher
    To gain insights into the virulence suppressive mechanism of a nonpathogenic strain of Rhizobium vitis ARK-1, we co-inoculated ARK-1 with a tumorigenic (Ti) strain of R...
  7. Hashemi H, Heydarian S, Khabazkhoob M, Yekta A, Emamian M, Fotouhi A. Keratometry in children: Comparison between auto-refractokeratometer, rotating scheimpflug imaging, and biograph. J Optom. 2019;12:99-110 pubmed publisher
    To determine the agreement and validity of keratometric measurements in children with the Nidek ARK-510A auto-refractokeratometer compared to rotating Scheimpflug imaging with Pentacam and biograph with Lenstar LS 900...
  8. Hirota M, Uozato H, Kawamorita T, Shibata Y, Yamamoto S. Effect of incomplete blinking on tear film stability. Optom Vis Sci. 2013;90:650-7 pubmed publisher
    ..Ltd., Nagoya, Japan) was used to measure ring breakup time as a parameter of tear film stability. An OPD-Scan II ARK-10000 (NIDEK Co., Ltd., Aichi, Japan) was used to measure corneal aberrations...
  9. Bekri A, Billaud M, Thélu J. Analysis of NUAK1 and NUAK2 expression during early chick development reveals specific patterns in the developing head. Int J Dev Biol. 2014;58:379-84 pubmed publisher
    ..These genes encode kinases, members of the AMPK-related kinases (ARK) gene family...
  10. Schneider J. The first mite: insect genealogy in Hooke's Micrographia. Ann Sci. 2018;75:165-200 pubmed publisher
    ..as tiny machines built from the same components and relates Hookean genealogies to contemporary ideas about Noah's Ark. Section 4 shows how Hooke outlined the morphology of 'insects' (delineating what we now call arthropods)...
  11. Karanth K, Nichols J, Karanth K, Hines J, Christensen N. The shrinking ark: patterns of large mammal extinctions in India. Proc Biol Sci. 2010;277:1971-9 pubmed publisher
    ..We find that 'culturally tolerated' species do exhibit higher persistence. Overall, large-bodied, rare and habitat specialist mammals tend to have higher extinction probabilities. ..
  12. Latta L, Nordstrom K, Stachon T, Langenbucher A, Fries F, Szentmary N, et al. Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model. Exp Eye Res. 2019;179:8-17 pubmed publisher
    ..is a sight-threatening disease involving progression of secondary glaucoma and aniridia related keratopathy (ARK). Change or loss of limbal epithelial progenitors causes epithelial surface defects...
  13. Zhao Q, Wu B, Liu Z, Sun X, Zhou L, Yang A, et al. Molecular cloning, expression and biochemical characterization of hemoglobin gene from ark shell Scapharca broughtonii. Fish Shellfish Immunol. 2018;78:60-68 pubmed publisher
    ..Research on immune of hemoglobin of ark shell Scapharca broughtonii attracted more and more attention due to its ownership of erythrocyte comparing with ..
  14. Li M, Zhu L, Zhou C, Lin L, Fan Y, Zhuang Z. Development and characterization of EST-SSR markers from Scapharca broughtonii and their transferability in Scapharca subcrenata and Tegillarca granosa. Molecules. 2012;17:10716-23 pubmed publisher
    Twenty-five novel EST-derived simple sequence repeat (EST-SSR) markers were developed in the ark shell Scapharca broughtonii...
  15. Fionda C, Abruzzese M, Zingoni A, Soriani A, Ricci B, Molfetta R, et al. Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. BMC Cancer. 2015;15:17 pubmed publisher
    ..Six MM cell lines, SKO-007(J3), U266, OPM-2, RPMI-8226, ARK and LP1 were used to investigate the activity of different nitric oxide donors [DETA-NO and the NO-releasing ..
  16. Xin L, Li C, Bai C, Wang C. Ostreid Herpesvirus-1 Infects Specific Hemocytes in Ark Clam, Scapharca broughtonii. Viruses. 2018;10: pubmed publisher
    ..This study aimed to ascertain if OsHV-1 infects specific types of hemocytes in ark clams. Types of hemocytes were first characterized through microexamination and flow cytometry...
  17. Dalla Pria A, Bendle M, Ramaswami R, Boffito M, Bower M. The pharmacokinetics of high-dose methotrexate in people living with HIV on antiretroviral therapy. Cancer Chemother Pharmacol. 2016;77:653-7 pubmed publisher
    ..Plasma MTX concentration was measured (ARK TM MTX assay, VITROS(®) 5600) daily after administration until levels were <0.04/mmol/L...
  18. Zheng L, Wu B, Liu Z, Tian J, Yu T, Zhou L, et al. A manganese superoxide dismutase (MnSOD) from ark shell, Scapharca broughtonii: Molecular characterization, expression and immune activity analysis. Fish Shellfish Immunol. 2015;45:656-65 pubmed publisher
    ..a full-length MnSOD cDNA was identified by rapid amplification of cDNA ends (RACE) method from cDNA library of ark shell Scapharca broughtonii (termed SbMnSOD)...
  19. Zhu M, Chen R, Zhong S, Qian Y, Huang Q. Medical resource preparation and allocation for humanitarian assistance based on module organization. Minerva Med. 2017;108:20-27 pubmed publisher
    ..The overseas humanitarian medical assistance mission, which was sent after a disaster on the hospital ship Peace Ark, part of China's People's Liberation Army (PLA) Navy, was considered as study model...
  20. Zhou L, Zhao D, Wu B, Sun X, Liu Z, Zhao F, et al. Ark shell Scapharca broughtonii hemocyte response against Vibrio anguillarum challenge. Fish Shellfish Immunol. 2019;84:304-311 pubmed publisher
    ..We aimed to investigate the immune responses of hemocytes from ark shell S. broughtonii hemolymph against pathogens...
  21. Wei D, Dao J, Chen G. A Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration. Adv Mater. 2018;30:e1802273 pubmed publisher
    ..PHA OPMs protect cells against stresses during injection, allowing more living cells to proliferate and migrate to damaged tissues. They function like a micro-Noah's Ark to safely transport cells to a defect tissue.
  22. Wang Q, Zhang M, Teng W, Fu C, Wang C, Liu Z, et al. [Effects of microalgal diets on juvenile growth and survival of the ark shell, Scapharca broughtonii]. Ying Yong Sheng Tai Xue Bao. 2014;25:2405-10 pubmed
    ..5-24.0 degrees C; salinity, 29.5-30.0), effects of microalgal diets on growth and survival of the juvenile ark shell, Scapharca broughtonii, were investigated for 24 days by feeding with diets made of single or combinatory use ..
  23. Käsmann Kellner B, Latta L, Fries F, Viestenz A, Seitz B. Diagnostic impact of anterior segment angiography of limbal stem cell insufficiency in PAX6-related aniridia. Clin Anat. 2018;31:392-397 pubmed publisher
    ..LSCI leads to ARK (aniridia-related keratopathy), which typically develops in four stages...
  24. Albanese G, Lee D, Cheng I, Hilt D, Jackwood M, Jordan B. Biological and molecular characterization of ArkGA: A novel Arkansas serotype vaccine that is highly attenuated, efficacious, and protective against homologous challenge. Vaccine. 2018;36:6077-6086 pubmed publisher
    ..In this study, we examined a different Ark vaccine strain (Ark99), which is no longer used commercially due to its reactivity in one day old chicks, to ..
  25. Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y, et al. Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6. J Biochem. 2015;158:61-71 pubmed publisher
    b>Arkadia, a positive regulator of Smad-dependent signalling via the transforming growth factor-β (TGF-β) family, is an E3 ubiquitin ligase that induces ubiquitylation and proteasome-dependent degradation of TGF-β suppressors such ..
  26. Si W, A R, Li S, Zhang J, Wu W, Cui Y. [Comparative analysis of seven marine biological source of mineral drugs]. Zhongguo Zhong Yao Za Zhi. 2014;39:3321-5 pubmed
    ..recorded in Chinese Pharmacopoeia (2010 version) mainly including pearl, nacre, clam shell, common oyster shell, ark shell, cuttle bone, and sea-ear shell are widely used in clinical...
  27. Bessarab D, Mathavan S, Jones C, Ray Dunn N. Zebrafish Rnf111 is encoded by multiple transcripts and is required for epiboly progression and prechordal plate development. Differentiation. 2015;89:22-30 pubmed publisher
    b>Arkadia (also known as RING finger 111) encodes a nuclear E3 ubiquitin ligase that targets intracellular effectors and modulators of TGFβ/Nodal-related signaling for polyubiquitination and proteasome-dependent degradation...
  28. Ivanković D, Erk M, Župan I, Culin J, Dragun Z, Bacic N, et al. Trace Metals in Noah's Ark Shells (Arca noae Linnaeus, 1758): Impact of Tourist Season and Human Health Risk. Arch Environ Contam Toxicol. 2016;71:394-404 pubmed publisher
    Commercially important bivalve Noah's Ark shell (Arca noae Linnaeus, 1758) represents a high-quality seafood product, but the data on levels of metal contaminants that could pose a human health risk and also on some essential elements ..
  29. Bai C, Rosani U, Xin L, Li G, Li C, Wang Q, et al. Dual transcriptomic analysis of Ostreid herpesvirus 1 infected Scapharca broughtonii with an emphasis on viral anti-apoptosis activities and host oxidative bursts. Fish Shellfish Immunol. 2018;82:554-564 pubmed publisher
    The ark shell, Scapharca (Anadara) broughtonii, is an economically important marine shellfish species in Northwestern Pacific...
  30. Miki T, Nishina M, Goshima G. RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens. Plant Cell Physiol. 2015;56:737-49 pubmed publisher
    ..drug treatment and showed that MTs and a plant-specific motor protein, armadillo repeat-containing kinesin (kinesin-ARK), are required for nuclear positioning in the moss Physcomitrella patens...
  31. Saleem J, Plew W, Speir R, Herout J, Wilck N, Ryan D, et al. Understanding barriers and facilitators to the use of Clinical Information Systems for intensive care units and Anesthesia Record Keeping: A rapid ethnography. Int J Med Inform. 2015;84:500-11 pubmed publisher
    ..Clinical Information Systems (CIS) for intensive care units (ICUs) and Anesthesia Record Keeping (ARK) for operating rooms and post-anesthesia care recovery settings at three Veterans Affairs Medical Centers (VAMCs)...
  32. Davis D, Abrams L. Here's looking at you: Visual similarity exacerbates the Moses illusion for semantically similar celebrities. J Exp Psychol Learn Mem Cogn. 2016;42:75-90 pubmed publisher
    When people read questions like "How many animals of each kind did Moses take on the ark?", many mistakenly answer "2" despite knowing that Noah sailed the ark. This "Moses illusion" occurs when names share semantic features...
  33. Hedrick E, Mohankumar K, Safe S. TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent. Mol Cancer Res. 2018;16:1991-2002 pubmed publisher
    ..cascade phosphorylates and induces nuclear export of NR4A1, which in turn forms an active complex with Axin2, Arkadia (RNF111), and RNF12 (RLIM) to induce proteasome-dependent degradation of SMAD7 and enhance lung cancer cell ..
  34. Jimeno S, Fernández Ávila M, Cruz García A, Cepeda García C, Gómez Cabello D, Huertas P. Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice. Nucleic Acids Res. 2015;43:987-99 pubmed publisher
    ..Thus, protein neddylation status has a great impact in the way cells respond to DNA breaks. ..
  35. Deng L, Lee M, Schutt K, Moseley J. Phosphatases Generate Signal Specificity Downstream of Ssp1 Kinase in Fission Yeast. Mol Cell Biol. 2017;37: pubmed publisher
    ..pombe, the CaMKK-like protein kinase Ssp1 promotes cell cycle progression by activating the ARK Cdr2 according to cell growth signals...
  36. Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell S, Prouteau M, et al. Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae. J Biol Chem. 2018;293:12043-12053 pubmed publisher
    ..observed that 25 of these sequences are phosphorylated by Fpk1 in vitro We focused on one sequence hit, the Ark/Prk-family kinase Akl1, as this kinase previously has been implicated in endocytosis...
  37. Xin L, Huang B, Bai C, Wang C. Validation of housekeeping genes for quantitative mRNA expression analysis in OsHV-1 infected ark clam, Scapharca broughtonii. J Invertebr Pathol. 2018;155:44-51 pubmed publisher
    ..Recently, events of mass mortalities of ark clams (Scapharca broughtonii) infected with OsHV-1 have been recorded...
  38. Saruhashi M, Kumar Ghosh T, Arai K, Ishizaki Y, Hagiwara K, Komatsu K, et al. Plant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2. Proc Natl Acad Sci U S A. 2015;112:E6388-96 pubmed publisher
    ..patens with reduced ABA sensitivity and reduced hyperosmosis tolerance revealed that a protein kinase designated "ARK" (for "ABA and abiotic stress-responsive Raf-like kinase") plays an essential role in the activation of SnRK2...
  39. Shin C, Jo H, Kim S, Kang G. Exposure assessment to paralytic shellfish toxins through the shellfish consumption in Korea. Food Res Int. 2018;108:274-279 pubmed publisher
    ..by marine dinoflagellates and can be accumulated in filter feeding shellfish, such as mussel, clam, oyster and ark shell. The worldwide regulatory limits for PSTs in shellfish are set at 80 μg STX eq...
  40. Erk M, Ivanković D, Župan I, Culin J, Dragun Z, Puljas S, et al. Changes in the tissue concentrations of trace elements during the reproductive cycle of Noah's Ark shells (Arca noae Linnaeus, 1758). Mar Pollut Bull. 2018;133:357-366 pubmed publisher
    ..V, Zn; non-essential: Ag, Al, As, Ba, Cd, Cr, Cs, Li, Ni, Pb, Rb, Sr, Ti, Tl, U) in whole soft tissues of Noah's Ark shell (Arca noae) were determined monthly during one year (March 2013-February 2014) at two sampling sites in the ..
  41. Watson M, Schnettler E, Kohl A. viRome: an R package for the visualization and analysis of viral small RNA sequence datasets. Bioinformatics. 2013;29:1902-3 pubmed publisher
    ..sf.net. Additional information and a tutorial is available on the ARK-Genomics website: http://www.ark-genomics.org/bioinformatics/virome. mick.watson@roslin.ed.ac.uk.
  42. Leiper L, Ou J, Walczysko P, Kucerova R, Lavery D, West J, et al. Control of patterns of corneal innervation by Pax6. Invest Ophthalmol Vis Sci. 2009;50:1122-8 pubmed publisher
    ..failure in ocular surface disease associated with heterozygosity at the Pax6 locus (aniridia-related keratopathy [ARK]) was investigated...
  43. James J, Slater F, Vaughan I, Young K, Cable J. Comparing the ecological impacts of native and invasive crayfish: could native species' translocation do more harm than good?. Oecologia. 2015;178:309-16 pubmed publisher
    ..Managed relocations of native crayfish from areas under threat from invasive crayfish into isolated 'ark sites' are sometimes suggested as a conservation strategy for native crayfish; however, such relocations may have ..
  44. Best B, Letendre S, Brigid E, Clifford D, Collier A, Gelman B, et al. Low atazanavir concentrations in cerebrospinal fluid. AIDS. 2009;23:83-7 pubmed publisher
    ..CSF samples were assayed by immunoassay (ARK ATV-test); lower limit of detection was 5 ng/ml. One hundred and seventeen participants (43 +/- 7...
  45. Abed M, Bitman Lotan E, Orian A. The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer. J Dev Biol. 2018;6: pubmed publisher
    ..Here, we review the lessons learned to date in Drosophila and highlight their relevance to cancer biology. ..
  46. Satterthwaite D, Sverdlik A, Brown D. Revealing and Responding to Multiple Health Risks in Informal Settlements in Sub-Saharan African Cities. J Urban Health. 2019;96:112-122 pubmed publisher
    ..first is from city case studies undertaken within a research programme called Urban Africa: Risk Knowledge (Urban-ARK)...
  47. Laursen J, Jeppesen P, Olsen T. Precision of 5 different keratometry devices. Int Ophthalmol. 2016;36:17-20 pubmed publisher
    ..215 D), which was significantly different from the other devices except for the IOLMaster. Nidek ARK had the lowest MAD (0.097 D), but this was not significant compared to Pentacam (0.124 D), Lenstar (0...
  48. Liu Y, Wang J, Avanzato V, Bakkum Gamez J, Russell S, Bell J, et al. Oncolytic vaccinia virotherapy for endometrial cancer. Gynecol Oncol. 2014;132:722-9 pubmed publisher
    ..Infectivity of VVNIS-C and VVNIS-W in type I (HEC1A, Ishikawa, KLE, RL95-2, and AN3 CA) and type II (ARK-1, ARK-2, and SPEC-2) human EC cell lines was evaluated...
  49. Bai C, Wang Q, Morga B, Shi J, Wang C. Experimental infection of adult Scapharca broughtonii with Ostreid herpesvirus SB strain. J Invertebr Pathol. 2017;143:79-82 pubmed publisher
    We investigated the susceptibility of ark shell, Scapharca broughtonii, adults to Ostreid herpesvirus SB strain (OsHV-1-SB) through experimental infection by intramuscular injection assays...
  50. Wu S, Xia F, Lin X, Duan K, Wang F, Lu Q, et al. Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways. Int J Mol Sci. 2016;17: pubmed publisher
    ..Taken together, our results provided the first evidence that Rd may promote the neurite outgrowth of PC12 cells by upregulating GAP-43 expression via ERK- and ARK-dependent signaling pathways.
  51. Liu J, Cao L, Dou S. Bioaccumulation of heavy metals and health risk assessment in three benthic bivalves along the coast of Laizhou Bay, China. Mar Pollut Bull. 2017;117:98-110 pubmed publisher
    ..species-specific bioaccumulation of heavy metals (Cr, Cu, Hg, Zn, As, Cd, and Pb) in three benthic bivalves (the ark shell, Scapharca subcrenata; the surf clam, Mactra veneriformis; and the Manila clam, Ruditapes philippinarum) ..
  52. Kim Y, Park S, Nam B, Kim D, Won S, Park J, et al. Aliisedimentitalea scapharcae gen. nov., sp. nov., isolated from ark shell Scapharca broughtonii. J Microbiol. 2015;53:495-502 pubmed publisher
    ..non-spore-forming, motile and ovoid or rod-shaped bacterial strain, designated MA2-16(T), was isolated from ark shell (Scapharca broughtonii) collected from the South Sea, South Korea...
  53. Ren A, Sun T, Wang H, Ge H, Ye H. Radiology on Board the PLA(N) Peace Ark Hospital Ship During a Humanitarian Medical Relief Mission to the Philippines. Disaster Med Public Health Prep. 2016;10:16-9 pubmed publisher
    From November 24 to December 10, 2013, the Chinese People's Liberation Army Navy [PLA(N)] hospital ship Peace Ark was deployed to the Leyte Gulf in the Philippines to provide humanitarian medical relief in Tacloban after Typhoon Haiyan...
  54. Greenland K, Chipungu J, Curtis V, Schmidt W, Siwale Z, Mudenda M, et al. Multiple behaviour change intervention for diarrhoea control in Lusaka, Zambia: a cluster randomised trial. Lancet Glob Health. 2016;4:e966-e977 pubmed publisher
    ..Complex caregiver practices can improve through interventions built around human motives, but these must be implemented more intensely. Absolute Return for Kids (ARK) and Comic Relief.
  55. Zhao Y, Lin L, Zhang Y, Geng D. SHP-2 Activating Mutation Promotes Malignant Biological Behaviors of Glioma Cells. Med Sci Monit. 2017;23:2931-2938 pubmed
    ..The activation of ERK1/2, ARK, and p38MAPK signal pathways in each group was determined by Western blot...
  56. Tsuneyoshi Y, Negishi K, Tsubota K. Importance of Accommodation and Eye Dominance for Measuring Objective Refractions. Am J Ophthalmol. 2017;177:69-76 pubmed publisher
    ..0 years; range, 25-60 years). Objective monocular refractions (MR) measured with the Nidek Auto Ref/Keratometer ARK-730A; objective binocular refractions (BR) and objective accommodative amplitude (AA) measured with the Grand Seiko ..
  57. Mort R, Bentley A, Martin F, Collinson J, Douvaras P, Hill R, et al. Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis. PLoS ONE. 2011;6:e28895 pubmed publisher
    ..PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial stem cell (LESC) deficiency...
  58. Das M, Ghosh M, Das S. Thyroid Hormone-Induced Differentiation of Astrocytes is Associated with Transcriptional Upregulation of β-arrestin-1 and β-adrenergic Receptor-Mediated Endosomal Signaling. Mol Neurobiol. 2016;53:5178-90 pubmed publisher
    ..qRT-PCR as well as Western blot analysis demonstrated that unlike β-adrenergic receptor kinase (β-ARK)1 and β-ARK2, the messenger RNA (mRNA) and protein levels of β-arrestin-1 in the astrocyte cultures increased ..
  59. Zheng L, Liu Z, Wu B, Dong Y, Zhou L, Tian J, et al. Ferritin has an important immune function in the ark shell Scapharca broughtonii. Dev Comp Immunol. 2016;59:15-24 pubmed publisher
    ..Detailed information about ferritin in the ark shell Scapharca broughtonii, however, has been very limited...
  60. Klijn S, Sicam V, Reus N. Long-term changes in intraocular lens position and corneal curvature after cataract surgery and their effect on refraction. J Cataract Refract Surg. 2016;42:35-43 pubmed publisher
    ..Refraction was measured with the ARK-530A autorefractor. The IOL position and corneal curvature were measured with the Lenstar LS-900 biometer...
  61. Klijn S, Reus N, van der Sommen C, Sicam V. Accuracy of Total Corneal Astigmatism Measurements With a Scheimpflug Imager and a Color Light-Emitting Diode Corneal Topographer. Am J Ophthalmol. 2016;167:72-8 pubmed publisher
    ..Refractive astigmatism was measured with the ARK-530A autorefractor (Nidek, Gamagori, Japan)...
  62. Roinioti E, Papathanassopoulou A, Theodoropoulou I, Simsek S, Theodoropoulos G. Molecular identification of Echinococcus granulosus isolates from ruminants in Greece. Vet Parasitol. 2016;226:138-44 pubmed publisher
    ..All nucleotide changes proved to be transitions (A?G or C?T). Two fertile hydatid cysts of sheep origin in different areas (Arkadia, Ilia) of the Peloponnese were identified as Echinococcus canadensis (G7 genotype).
  63. Kim Y, Park S, Nam B, Park J, Kim D, Yoon J. Roseovarius scapharcae sp. nov., isolated from ark shell Scapharca broughtonii. Int J Syst Evol Microbiol. 2015;65:4695-700 pubmed publisher
    A Gram-stain-negative, non-motile, aerobic and ovoid or rod-shaped bacterium, designated MA4-5T, was isolated from ark shell (Scapharca broughtonii) collected from the South Sea, South Korea...
  64. Kobelja K, Nemet I, Župan I, Culin J, Roncević S. Elemental profiling of Noah's Ark shell (Arca noae, Linnaeus, 1758) by plasma optical spectrometry and chemometric tools. J Trace Elem Med Biol. 2016;38:157-164 pubmed publisher
    ..In this study, elemental profile of mussel shell of Noah's Ark (Arca noe, Linnaeus, 1758), which inhabit eastern Adriatic Sea was obtained by determination of seventeen elements ..
  65. Liu Y, Steele M, Suksanpaisan L, Federspiel M, Russell S, Peng K, et al. Oncolytic measles and vesicular stomatitis virotherapy for endometrial cancer. Gynecol Oncol. 2014;132:194-202 pubmed publisher
    ..Human EC cell lines (HEC-1-A, Ishikawa, KLE, RL95-2, AN3 CA, ARK-1, ARK-2, and SPEC-2) were infected with Edmonston strain MV expressing the thyroidal sodium iodide symporter, VSV ..
  66. Jiang X, Cheng H, Zheng B, Li A, Lv L, Ling Z, et al. Comparative genomic study of three species within the genus Ornithinibacillus, reflecting the adaption to different habitats. Gene. 2016;578:25-31 pubmed publisher
    ..with their close relative Ornithinibacillus scapharcae TW25(T), a putative pathogenic bacteria isolated from dead ark clam. The comparisons showed O...
  67. Stepanek O, Horin P. Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic. J Appl Genet. 2017;58:111-121 pubmed publisher
    ..In this cohort, haplotypes ARR, ARQ, ARH, AHQ, VRQ, AHR and ARK were detected...
  68. Zhou L, Yang A, Liu Z, Wu B, Sun X, Lv Z, et al. Changes in hemolymph characteristics of ark shell Scapharaca broughtonii dealt with Vibrio anguillarum challenge in vivo and various of anticoagulants in vitro. Fish Shellfish Immunol. 2017;61:9-15 pubmed publisher
    The ark shell Scapharca broughtonii is a commercially important shellfish in China. Alserver's solution (AS), modified Alserver's solution (MAS) and Heparin sodium solution (HSS) are common anticoagulants used for shellfish blood...
  69. Liu L, Shi M, Wang Y, Zhang C, Su B, Xiao Y, et al. SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy. PLoS ONE. 2017;12:e0174471 pubmed publisher
    ..High glucose stress induced significantly elevated SnoN, TGF-β1, and Arkadia transcription; however, significantly reduced SnoN protein levels were observed under these conditions...
  70. Negi A, Alex J, Amrutkar S, Baviskar A, Joshi G, Singh S, et al. Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-α inhibition. Bioorg Med Chem. 2015;23:5654-61 pubmed publisher
    ..Compounds ARK-4, 10 and 12 in the series show promising in vitro anti proliferative activity with low micromolar IC50 values ..
  71. Khandan M, Nili M, Koohpaei A, Mosaferchi S. Integrating the Ergonomics Techniques with Multi Criteria Decision Making as a New Approach for Risk Management: An Assessment of Repetitive Tasks -Entropy Case Study. J Res Health Sci. 2016;16:85-9 pubmed
    ..approach and 13 tasks were included from total number of employees who were working in the seven halls of an ark opal manufacturing (240)...
  72. Kalogera E, Roy D, Khurana A, Mondal S, Weaver A, He X, et al. Quinacrine in endometrial cancer: Repurposing an old antimalarial drug. Gynecol Oncol. 2017;146:187-195 pubmed publisher
    ..Five different EC cell lines (Ishikawa, Hec-1B, KLE, ARK-2, and SPEC-2) representing different histologies, grades of EC, sensitivity to cisplatin and p53 status were used ..
  73. Toro H, van Santen V, Ghetas A, Joiner K. Cross-Protection by Infectious Bronchitis Viruses Under Controlled Experimental Conditions. Avian Dis. 2015;59:532-6 pubmed publisher
    ..boosted with a Massachusetts (Mass)-type attenuated vaccine were subsequently challenged with either IBV Arkansas (Ark) or GA13-type virulent strains. In addition, Ark-vaccinated chickens were challenged with IBV GA13...
  74. Loprinzi P, Joyner C. Accelerometer-determined physical activity and mortality in a national prospective cohort study: Considerations by visual acuity. Prev Med. 2016;87:18-21 pubmed publisher
    ..NHANES were employed, with physical activity assessed via accelerometry and visual function assessed using the ARK-760 autorefractor...
  75. Sharma V, Antonacopoulou A, Tanaka S, Panoutsopoulos A, Bravou V, Kalofonos H, et al. Enhancement of TGF-? signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer. Cancer Res. 2011;71:6438-49 pubmed publisher
    ..Mechanisms that support its tumor-suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances TGF-? signaling responses by targeting repressors of the pathway for degradation...
  76. Chasapis C, Kandias N, Episkopou V, Bentrop D, Spyroulias G. NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase. Proteins. 2012;80:1484-9 pubmed publisher
    b>Arkadia (Rnf111), an E3 Ubiquitin (Ub) ligase, amplifies TGF-β signaling responses by targeting for degradation of the negative regulators Smad6/7 and the SnoN/Ski transcriptional repressors when they block the TGF-β effectors Smad2/3...
  77. Erker Y, Neyret Kahn H, Seeler J, Dejean A, Atfi A, Levy L. Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. Mol Cell Biol. 2013;33:2163-77 pubmed publisher
    b>Arkadia is a RING domain E3 ubiquitin ligase that activates the transforming growth factor ? (TGF-?) pathway by inducing degradation of the inhibitor SnoN/Ski...
  78. van Cuijk L, van Belle G, Turkyilmaz Y, Poulsen S, Janssens R, Theil A, et al. SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair. Nat Commun. 2015;6:7499 pubmed publisher
  79. Wright J, Mace P, Day C. Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. Nat Struct Mol Biol. 2016;23:45-52 pubmed publisher
    ..Here we report that the monomeric RING domains from the human E3 ligases Arkadia and Ark2C bind directly to free ubiquitin with an affinity comparable to that of other dedicated ubiquitin-..
  80. Nakano T, Yamada K, Okamura K. Duration rather than frequency of hypoxia causes mass mortality in ark shells (Anadara kagoshimensis). Mar Pollut Bull. 2017;125:86-91 pubmed publisher
    ..study aimed to demonstrate this relationship and to evaluate how the duration of hypoxia affects the survival of ark shells (Anadara kagoshimensis) using mathematical modeling...
  81. Patten I, Placzek M. Vertebrate development: Et in Arkadia. Curr Biol. 2001;11:R616-9 pubmed
    ..Recent evidence suggests a common mechanism, in which an intracellular protein, Arkadia, is required for formation of the mouse organiser and potentiates the effects of the signalling protein Nodal.
  82. Poeta L, Fusco F, Drongitis D, Shoubridge C, Manganelli G, Filosa S, et al. A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. Am J Hum Genet. 2013;92:114-25 pubmed publisher
    ..We established that ARX polyA alterations damage the regulation of KDM5C expression, and we propose a potential ARX-dependent path acting via chromatin remodeling. ..
  83. Ma T, Chen Y, Zhang F, Yang C, Wang S, Yu X. RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Mol Cell. 2013;49:897-907 pubmed publisher
    ..Loss of DNA damage-induced neddylation negatively regulated DNA damage-induced foci formation of RNF168 and its downstream functional partners, such as 53BP1 and BRCA1, thus affecting the normal DNA damage repair process. ..
  84. Briones Orta M, Levy L, Madsen C, Das D, Erker Y, Sahai E, et al. Arkadia regulates tumor metastasis by modulation of the TGF-? pathway. Cancer Res. 2013;73:1800-10 pubmed publisher
    ..The E3 ubiquitin ligase Arkadia (RNF111) is a critical component of the TGF-? signaling pathway, being required for a subset of responses, those ..
  85. Chen H, Yang T, Lei Z, Wang L, Yang H, Tong X, et al. RNF111/Arkadia is regulated by DNA methylation and affects TGF-β/Smad signaling associated invasion in NSCLC cells. Lung Cancer. 2015;90:32-40 pubmed publisher
    RNF111/Arkadia is a critical regulator of TGF-β signaling, being required for SMAD3-mediated responses such as TGF-β-induced repression of E-cadherin...
  86. Mizutani A, Koinuma D, Seimiya H, Miyazono K. The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma. Oncogene. 2016;35:3514-23 pubmed publisher
    ..but the expression of some ESRP-target exons correlated with the good prognosis and with the expression of Arkadia (also known as RNF111) in ccRCC...
  87. Perera N, Godahewa G, Lee J. Mitogen-activated protein kinase 1 from disk abalone (Haliotis discus discus): Roles in early development and immunity-related transcriptional responses. Fish Shellfish Immunol. 2016;59:57-65 pubmed publisher
    ..Homology assessment of AbMAPK1 showed several conserved regions, and ark clam (Aplysia californica) showed the highest sequence identity (87.9%)...
  88. Liu F, Li X, Peng Y, Liu H, Liu Y. Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition. Kidney Int. 2008;73:588-94 pubmed
    ..In this study, we examined the role of Arkadia, an E3 ubiquitin ligase that is critically required for TGF-beta signaling during epithelial to mesenchymal cell ..
  89. Sun H, Hunter T. Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem. 2012;287:42071-83 pubmed publisher
    ..We found clustered SIMs in another RING domain protein Arkadia/RNF111...
  90. Xia T, Levy L, Levillayer F, Jia B, Li G, Neuveut C, et al. The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor ? (TGF-?) signaling by regulating ubiquitination of the E3 ligase Arkadia. J Biol Chem. 2013;288:1785-94 pubmed publisher
    b>Arkadia is a RING-based ubiquitin ligase that positively regulates TGF-? signaling by targeting several pathway components for ubiquitination and degradation. However, little is known about the mechanisms controlling Arkadia activity...
  91. Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou K, Samiotaki M, et al. SET9-Mediated Regulation of TGF-? Signaling Links Protein Methylation to Pulmonary Fibrosis. Cell Rep. 2016;15:2733-44 pubmed publisher
    ..Smad7 methylation promotes interaction with the E3 ligase Arkadia and, thus, ubiquitination-dependent degradation...
  92. de Wit J, Cazaban C, Dijkman R, Ramon G, Gardin Y. Detection of different genotypes of infectious bronchitis virus and of infectious bursal disease virus in European broilers during an epidemiological study in 2013 and the consequences for the diagnostic approach. Avian Pathol. 2017;:1-12 pubmed publisher
    ..Strains belonging to the Q1, Ark, D274, D1466, Italy-02 and B1648 genotypes were detected as well, although less frequently...