Genomes and Genes
Gene Symbol: ARHGEF2
Description: Rho/Rac guanine nucleotide exchange factor (GEF) 2
Alias: GEF, GEF-H1, GEFH1, LFP40, P40, Rho/Rac guanine nucleotide exchange factor 2, guanine nucleotide exchange factor H1, microtubule-regulated Rho-GEF, proliferating cell nucleolar antigen p40, rho guanine nucleotide exchange factor 2
Publications158 found, 100 shown here
- p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factorFrank T Zenke
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 279:18392-400. 2004b>GEF-H1 is a guanine nucleotide exchange factor for Rho whose activity is regulated through a cycle of microtubule binding and release...
- The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migrationAnna Tsapara
Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
Mol Biol Cell 21:860-70. 2010..Here, we show that primary RPE cells up-regulated GEF-H1 in response to TGF-beta...
- The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epitheliumEli Kakiashvili
Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, and Department of Surgery, University of Toronto, Toronto, Ontario M5B 1W8, Canada
J Biol Chem 286:9268-79. 2011..We have previously shown that ERK-mediated stimulation of the RhoA GDP/GTP exchange factor GEF-H1/Lfc is critical for TNF-α-induced RhoA stimulation...
- Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriersLogan C Walker
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD, Australia
Breast Cancer Res Treat 112:229-36. 2008..Similar approaches may be used to identify genes and underlying genetic risk factors that interact with exogenous stimulants to cause or modify any disease, without a priori knowledge of the pathways involved...
- Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cellsShinji Mizuarai
Functional Genomics, Banyu Tsukuba Research Institute, Merck Research Laboratory, Tsukuba, Ibaraki, Japan
Cancer Res 66:6319-26. 2006..In the present study, we showed that GEF-H1, a guanine exchange factor-H1 for RhoA, is transcriptionally activated by the induction of mutant p53 proteins, ..
- ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoAShuh Hei Fujishiro
Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 14, Bunkyo Machi, Nagasaki 852 8521, Japan
Biochem Biophys Res Commun 368:162-7. 2008..We have examined whether ERK1/2 are involved in the phosphorylation of GEF-H1, a GEF toward RhoA, to modulate its activity...
- GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoAYuan Chen Chang
Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Mol Biol Cell 19:2147-53. 2008..b>GEF-H1 is a microtubule-associated guanine nucleotide exchange factor that activates RhoA upon release from ..
- Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPasesY Ren
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 273:34954-60. 1998..The Dbl-like guanine nucleotide exchange factors (GEF) have been implicated in direct activation of these GTPases...
- Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeletonMira Krendel
Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Nat Cell Biol 4:294-301. 2002..Here we show that the Rho guanine nucleotide exchange factor (GEF)-H1 is regulated by an interaction with microtubules...
- Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transitionSaima Aijaz
Division of Cell Biology, Institute of Ophthalmology, University College London, UK
Dev Cell 8:777-86. 2005..Here we show that GEF-H1/Lfc, a guanine nucleotide exchange factor for RhoA, directly interacts with cingulin, a junctional adaptor...
- ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and functionM Franco
Centre d Immunologie Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique de Marseille Luminy, Case 906, 13288 Marseille Cedex 9, France
Proc Natl Acad Sci U S A 95:9926-31. 1998..We recently have identified a human protein, ARNO (ARF nucleotide-binding-site opener), as an ARF1-GEF that shares a conserved domain with the yeast Sec7 protein...
- Antagonistic effects of NES and NLS motifs determine S. cerevisiae Rna1p subcellular distributionW Feng
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Cell Sci 112:339-47. 1999..In yeast Rna1p is the GTPase activating protein for Ran (RanGAP) and Prp20p is the Ran GDP/GTP exchange factor (GEF). RanGAP is primarily cytosolic and GEF is nuclear...
- Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequencesA Matynia
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 16:6352-62. 1996..products, rna1p and pim1p, functioning as GTPase-activating protein (GAP) and guanine nucleotide exchange factor (GEF), respectively...
- RCC1 in the Ran pathwayT Seki
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka
J Biochem 120:207-14. 1996RCC1 is a chromosomal protein that functions as a GEF of the nuclear G protein Ran, which GTPase activity is enhanced by RNA1 located in the cytoplasm...
- Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factorsPiyi Papadaki
Biology Department, New York University, New York, New York 10003 6688, USA
Mol Cell Biol 22:4598-606. 2002..Ras1 activates Scd1, a presumptive guanine nucleotide exchange factor (GEF) for Cdc42, to control morphogenesis and chromosome segregation, and Byr2, a component of a mitogen-activated ..
- Quantitative morphology and postsynaptic targets of thalamocortical axons in critical period and adult ferret visual cortexAlev Erisir
University of Virginia, Department of Psychology, Charlottesville, Virginia 22904 4400, USA
J Comp Neurol 485:11-31. 2005..anterograde tract-tracing display significantly larger cross-section areas than terminals at postnatal day (P) 35, P40, and P49 critical period ages...
- Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-RasX Gao
Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Japan
J Biol Chem 276:42219-25. 2001..RA-GEF-1 was identified as a novel Rap GEF, which possesses a Ras/Rap1-associating (RA) domain...
- Interaction between 3' untranslated region of calcitonin receptor messenger ribonucleic acid (RNA) and adenylate/uridylate (AU)-rich element binding proteins (AU-rich RNA-binding factor 1 and Hu antigen R)Shigemitsu Yasuda
Fourth Department of Internal Medicine, Saitama Medical School, Japan
Endocrinology 145:1730-8. 2004..3'UTR transcripts bound with a 40-kDa protein, which could be extracted from cells transfected with AUF1 p40. To confirm the binding specificity, a pSG5 vector construct, containing the AUF1 p40 with an hemagglutinin tag, ..
- Measles virus N protein inhibits host translation by binding to eIF3-p40Hiroki Sato
Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Virol 81:11569-76. 2007..by using MV-N as bait and screening the human T-cell cDNA library by yeast two-hybrid assay and isolated the p40 subunit of eukaryotic initiation factor 3 (eIF3-p40) as a binding partner...
- Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosisK Shigehara
First Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
Clin Exp Immunol 132:152-7. 2003..The serum concentration of IL-12 p40 was detectable in all 45 patients with pulmonary sarcoidosis and 18 normal controls, whereas that of IL-12 p70 was ..
- Spinal dural arteriovenous malformations. Intraoperative evoked potential evidence for pathophysiology. A case reportM M Stecker
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Spine (Phila Pa 1976) 21:512-5. 1996..RESULTS. At baseline, the cortical (P40) potential was markedly prolonged bilaterally...
- In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70Karen L Elkins
Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, Rockville, Maryland 20852, USA
Infect Immun 70:1936-48. 2002..Mice lacking the p40 protein of IL-12 (p40 knockout [KO] mice) and mice treated in vivo with neutralizing anti-IL-12 antibodies survived ..
- Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonistS Gillessen
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110
Eur J Immunol 25:200-6. 1995..that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide-bonded subunits, p40 and p35...
- Effects of stimulus intensity and duration on posterior tibial nerve somatosensory-evoked potential patterns obtained under anesthesiaM Rappaport
University of California Brain Function Study Unit, Agnews Developmental Center, San Jose
Spine (Phila Pa 1976) 19:1525-9. 1994..RESULTS. Three latencies yielded stable findings (P40, N50, P60). Peak latencies under anesthesia were not affected by stimulus intensity or duration...
- Role of Mycoplasma penetrans endonuclease P40 as a potential pathogenic determinantM Bendjennat
Laboratory of Immunovirology UFR SVT, University of Paul Sabatier, 31062 Toulouse, France
Infect Immun 67:4456-62. 1999..we reported the purification to homogeneity and characterization of Ca(2+)- and Mg(2+)-dependent endonuclease P40 produced by Mycoplasma penetrans (M. Bendjennat, A. Blanchard, M. Loutfi, L. Montagnier, and E. Bahraoui, J...
- Complementation of NADPH oxidase in p67-phox-deficient CGD patients p67-phox/p40-phox interactionS Vergnaud
GREPI, Laboratoire d Enzymologie, CHU, Grenoble, France INSERM U 479, CHU, Bichat, Paris, France
Eur J Biochem 267:1059-67. 2000..b558 that was associated with cytosol or with the isolated cytosolic-activating factors (p67-phox, p47-phox, p40-phox) from healthy or CGD patients...
- IL-12 and IFN-gamma production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infectionsM I Antunez
Instituto Nacional de Parasitologia Dr M Fatala Chaben, ANLIS Dr C G Malbran, Buenos Aires, Argentina
Immunol Lett 71:103-9. 2000..cruzi, Tulahuén strain was studied. The levels of interleukin-12 p40 (IL-12 p40) and IFN-gamma, as well as natural killer (NK) cell cytotoxicity were determined at different time-..
- Effect of CYP2C19*2 and *17 mutations on pharmacodynamics and kinetics of proton pump inhibitors in CaucasiansNicole G Hunfeld
Central Hospital Pharmacy, The Hague, The Netherlands
Br J Clin Pharmacol 65:752-60. 2008..Furthermore, a novel CYP2C19 mutation, *17, which mainly occurs in Caucasians has been discovered. This mutation has been associated with clinical failure, but its relevance for therapy with PPIs has not been studied yet...
- Modulation of IL-12 p35 and p40 promoter activity by smokeless tobacco extract is associated with an effect upon activation of NF-kappaB but not IRF transcription factorsThomas M Petro
Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, 40th and Holdrege Streets, Lincoln, NE 68583 0740, USA
Int Immunopharmacol 3:735-45. 2003Interleukin (IL)-12 (p70), composed of p35 and p40 subunits, stimulates cellular immunity and inflammation. Stimulation of IL-12 production by smokeless tobacco extract (STE) could increase the chances of oral inflammatory disease...
- Lack of interleukin-12 in p40-deficient mice leads to poor CD8+ T-cell immunity against Encephalitozoon cuniculi infectionMagali M Moretto
Department of Microbiology, George Washington University, 2300 I Street, Washington, DC 20037, USA
Infect Immun 78:2505-11. 2010..In the present study, we demonstrated that p40-deficient animals, which are unable to produce interleukin-12 (IL-12), have a serious defect in expansion of the ..
- Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activityP Ling
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche, Inc, Nutley, NJ 07110
J Immunol 154:116-27. 1995IL-12, a heterodimeric cytokine, consists of two disulfide-linked subunits, p40 and p35. We investigated the role of p40 in ligand binding and signal transduction by expressing this subunit alone in COS cells...
- Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disordersLaetitia Horzinski
INSERM U931 CNRS 6247 Université Clermont, GReD, Clermont Ferrand, France
PLoS ONE 4:e8318. 2009..Decreased eIF2B GEF activity has been previously reported in lymphoblastoid cell lines from 30 eIF2B-mutated patients...
- Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cellsA D'ANDREA
Wistar Institute of Anatomy and Biology, Children s Hospital of Philadelphia, Pennsylvania 19104
J Exp Med 176:1387-98. 1992..NKSF), or interleukin 12 (IL-12), is a 70-kD heterodimeric cytokine composed of two covalently linked chains, p40 and p35...
- The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cellsX Ma
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA
J Exp Med 183:147-57. 1996..IL-12 production mostly by priming phagocytic cells for lipopolysaccharide (LPS)-induced transcription of the IL-12 p40 gene, which encodes the heavy chain of the IL-12 heterodimer; furthermore, IFN-gamma directly induces transcription ..
- PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanismsE M Rottjakob
Department of Biochemistry, University of Missouri, Columbia 65212, USA
J Virol 70:3176-88. 1996..The ability of v-Rel, the oncogenic viral counterpart of avian c-Rel, to evade regulation by p40, the avian IkappaB-alpha protein, contributes to v-Rel-mediated oncogenesis...
- Dual system to reinforce biological containment of recombinant bacteria designed for rhizoremediationM C Ronchel
Department of Biochemistry and Molecular and Cellular Biology of Plants, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, 18008 Granada, Spain
Appl Environ Microbiol 67:2649-56. 2001..g., a porin-inducing protein such as the one encoded by the Escherichia coli gef gene, and a regulatory circuit that controls expression of the killing gene in response to the presence or absence ..
- Estimation of left ventricular systolic function by single transpulmonary thermodilutionAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Intensive Care Med 30:1377-83. 2004..The global cardiac systolic function may be decreased despite preserved left ventricular function in this situation.)..
- RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humansY Liao
Department of Physiology II, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 274:37815-20. 1999..for Ras-binding proteins in nematode Caenorhabditis elegans has identified a guanine nucleotide exchange factor (GEF) containing a Ras/Rap1A-associating (RA) domain, termed Ce-RA-GEF...
- Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase SrcM Kiyono
Faculty of Bioscience, Tokyo Institute of Technology, Yokohama 226 8501, Japan
J Biol Chem 275:5441-6. 2000Ras-GRF1/CDC25(Mm) has been implicated as a Ras-guanine nucleotide exchange factor (GEF) expressed in brain. Ras-GEF activity of Ras-GRF1 is augmented in response to Ca(2+) influx and G protein betagamma subunit (Gbetagamma) stimulation...
- Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathwayJun Hee Lee
National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305 701, Korea
Mol Cell Biol 22:7658-66. 2002PDZ-GEF is a novel guanine nucleotide exchange factor for Rap1 GTPase...
- Characterization and localized expression of the laminin binding protein/p40 (LBP/p40) gene during sea urchin developmentM Hung
Department of Biological Sciences, California State University, Hayward 94542, USA
Exp Cell Res 221:221-30. 1995..of a cDNA clone from the sea urchin Strongylocentrotus purpuratus that encodes a protein very similar to LBP/p40, originally identified as a nonintegrin, 67-kDa laminin binding protein...
- Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cellsS F Wolf
Genetics Institute, Inc, Cambridge, MA 02140
J Immunol 146:3074-81. 1991..NKSF was found to be a disulfide-linked heterodimeric protein composed of 35-kDa and 40-kDa subunits (p35 and p40). We now report the molecular cloning of cDNA for both subunits of NKSF from RPMI 8866 cellular RNA...
- Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neuronsAngela Bithell
Section of Experimental Neuropathology and Psychiatry, Department of Psychological Medicine, The Institute of Psychiatry P052, De Crespigny Park, London SE5 8AF, UK
Brain Res Dev Brain Res 146:107-18. 2003..Here we report that one of these genes, encoding a guanine nucleotide exchange factor (GEF), is regulated during the differentiation of distinct neuronal populations...
- Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70Katsuhiko Suzuki
Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
Exerc Immunol Rev 9:48-57. 2003..produce type-1 cytokines such as IL-2 and interferon (IFN), thereby supporting cellular immunity, whereas IL-12 p40 acts as an antagonist of IL-12 p70...
- The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteinsRaphael Gasper
Abteilung Strukturelle Biologie, Max Planck Institut fur molekulare Physiologie, 44227 Dortmund, Germany
J Mol Biol 379:51-63. 2008..The mechanism involves the formation of trimeric G protein-nucleotide-GEF complexes, followed by the release of nucleotide to form stable binary G protein-GEF complexes...
- cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytesAnna Gates
Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA
Am J Physiol Gastrointest Liver Physiol 296:G764-74. 2009Cyclic AMP protects against hepatocyte apoptosis by a protein kinase A-independent cAMP-GEF/phosphoinositide-3-kinase (PI3K)/Akt signaling pathway. However, the signaling pathway coupling cAMP-GEF with PI3K is unknown...
- Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1M Kiyono
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226 8501, Japan
J Biol Chem 275:29788-93. 2000Ras-GRF1 is a brain-specific guanine nucleotide exchange factor (GEF) for Ras, whose activity is regulated in response to Ca(2+) influx and G protein-coupled receptor signals...
- Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factorsMichael A Kwofie
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Biol Chem 283:3088-96. 2008Recognition of cognate Rho GTPases by guanine-nucleotide exchange factors (GEF) is fundamental to Rho GTPase signaling specificity...
- betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowthEun Young Shin
Department of Biochemistry, College of Medicine, Chungbuk National University, Cheongju 361 763, Korea
J Biol Chem 281:35954-64. 2006..1994-2004), we demonstrated that betaPak-interacting exchange factor (betaPIX) guanine nucleotide exchange factor (GEF) mediates basic fibroblast growth factor (bFGF)-stimulated Rac1 activation through phosphorylation of Ser-525 and ..
- Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activityMartin R Schiller
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3401, USA
Exp Cell Res 307:402-17. 2005Guanine nucleotide exchange factor (GEF) domains of the Dbl family occur in a variety of proteins that include multiple protein-protein and protein-lipid interaction domains...
- The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domainsA Debant
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 93:5466-71. 1996..isolated a cDNA encoding a 2861-amino acid protein termed Trio that contains three enzyme domains: two functional GEF domains and a protein serine/threonine kinase (PSK) domain...
- Guanine nucleotide exchange factor independence of the G-protein eEF1A through novel mutant forms and biochemical propertiesSedide B Ozturk
Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Biol Chem 283:23244-53. 2008Most G-proteins require a guanine nucleotide exchange factor (GEF) to regulate a variety of critical cellular processes. Interestingly, a small number of G-proteins switch between the active and inactive forms without a GEF...
- Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophagesGyorgy Hasko
Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
J Pharmacol Exp Ther 301:103-10. 2002..in the regulation of lipopolysaccharide (LPS) and/or interferon (IFN)-gamma-induced interleukin (IL)-12 p40 and tumor necrosis factor (TNF)-alpha production, nitric oxide formation, as well as major histocompatibility ..
- Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27Lunyin Yu
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
Am J Respir Cell Mol Biol 44:524-30. 2011..We also investigated the effect of guanine nucleotide exchange factor (GEF)-H1, an upstream regulator of RhoA, on heparin inhibition of PASMC proliferation by GEF-H1 cDNA transfection...
- Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorderAngela Bithell
Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
PLoS ONE 5:e10392. 2010..The Rap-1 guanine nucleotide exchange factor, MR-GEF, is turned on by many of these developing GABAergic neurons...
- Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activityD Dailey
Department of Molecular and Cell Biology, University of California, Berkeley 94720
Mol Cell Biol 10:6244-56. 1990..level of tyrosine kinase activity at all steps of each preparation correlated with the content of a 40-kDa protein (p40)...
- Protective immunity induced with 23 kDa membrane protein dna vaccine of Schistosoma japonicum Chinese strain in infected C57BL/6 miceYingchang Zhu
Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China
Southeast Asian J Trop Med Public Health 34:697-701. 2003..m.) with a mixture of 100 microg of pcDNA3.1-SjC23, 100 microg of pcDNA3.1-p35 and 100 microg of pcDNA-p40. These were followed by two boosts of the same DNA once every two weeks...
- Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genesM P Hayes
Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892, USA
Blood 86:646-50. 1995..factor (GM-CSF) provided an equivalent priming stimulus for LPS-induced tumor necrosis factor (TNF) and IL-12 p40 mRNA, but primed poorly for LPS-inducible p35 message and secreted IL-12 activity...
- Do subplate neurons comprise a transient population of cells in developing neocortex of rats?R T Robertson
Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, California 92697 1280, USA
J Comp Neurol 426:632-50. 2000..dissector method was used to analyze fluorescently stained material in animals the age of postnatal day 0 (P0) to P40. These results demonstrate a reduction of slightly less than half of the total number of subplate neurons from P0 ..
- Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patientsTomomi Toubai
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Eur J Haematol 77:403-9. 2006Interleukin (IL)-12 is a 70-kDa cytokine comprised of two disulfide-linked proteins (p35 and p40) and is essential for the initiation of effective immune response...
- Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70Malabendu Jana
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Immunology 127:312-25. 2009Interleukin-12 (IL-12) p70 (p40:p35) is a bioactive cytokine and its biological functions are becoming clear...
- Characterization of p40 and IL-10 in the BALF of patients with pulmonary sarcoidosisVirginie Barbarin
Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Brussels, Belgium
J Interferon Cytokine Res 23:449-56. 2003This study investigated cytokine protein levels (interleukin-12 p70 [IL-12p70], p40, and IL-10) in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis (n = 59), healthy control subjects (n = 17), and patients ..
- Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophagesMalabendu Jana
Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583 0740, USA
J Neurochem 86:519-28. 2003The present study was undertaken to explore the role of interleukin-12 (IL-12) p40 in the expression of TNF-alpha in microglia...
- Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stressM Landriscina
Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
J Biol Chem 276:25549-57. 2001..is known to be released in response to stress conditions as a component of a multiprotein aggregate containing the p40 extravescicular domain of p65 synaptotagmin (Syt) 1 and S100A13...
- Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging studyBenjamin M Segal
Department of Neurology, Holtom Garrett Programme in Neuroimmunology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Lancet Neurol 7:796-804. 2008Repeated subcutaneous injections of a monoclonal antibody against the p40 subunit of interleukins 12 and 23, ustekinumab, were used to treat patients with relapsing-remitting multiple sclerosis (RRMS) to assess the drug's safety, ..
- Ovarian follicular concentration of IL-12, IL-15, IL-18 and p40 subunit of IL-12 and IL-23Sanja Vujisic
Department of Obstetrics and Gynecology, Medical School, University of Zagreb, Sveti Duh Hospital, Croatia
Hum Reprod 21:2650-5. 2006The aim of the study was to determine the presence of interleukin (IL)-12, IL-15, IL-18 and p40 subunit of IL-12/IL-23 in follicular fluid from spontaneous cycles and the relation between the concentration of selected cytokines and IVF-..
- Generation of an active protein-tyrosine kinase from lymphocytes by proteolysisT F Zioncheck
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907
J Biol Chem 263:19195-202. 1988..found in soluble thymus extracts, as measured by the phosphorylation of angiotensin I, is a 40-kDa enzyme known as p40 (Zioncheck, T. F., Harrison, M. L., and Geahlen, R. L. (1986) J. Biol. Chem. 261, 15637-15643)...
- Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-relChandra Sekhar Boddupalli
Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500076, Andhra Pradesh, India
Free Radic Biol Med 42:686-97. 2007..macrophages, the rel/NF-kappaB transcription factors are known to play important roles in interleukin-12 (IL-12) p40 regulation by nitric oxide (NO). However, the relative contributions of these factors are not well understood...
- Accumulation of processing intermediates of the RAS2 protein in strain 112 of Saccharomyces cerevisiaeD Breviario
Istituto Tecnologie Biomediche Avanzate, CNR, Milano, Italy
Biochem Biophys Res Commun 151:1346-51. 1988..molecule of 41000 daltons (p41), 112 cells accumulate within the soluble fraction an intermediate form of RAS2 (p40-1), which migrates, in SDS-polyacrylamide gel, between p41 and the fully processed, membrane-bound 40,000 daltons (..
- Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agentsMaria Laura Belladonna
a Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
Biotechnol Genet Eng Rev 29:149-74. 2013..By sharing cytokine and receptor subunits, IL-12 (comprised of p40/p35 subunits), IL-23 (p40/p19), IL-27 (p28/EBI3), and IL-35 (p35/EBI3) represent, as a whole, a highly versatile ..
- Superoxide inhibits guanine nucleotide exchange factor (GEF) action on Ras, but not on Rho, through desensitization of Ras to GEFMichael Wey
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States
Biochemistry 53:518-32. 2014..However, the effect of oxidants on GEF functions, or vice versa, has not been known...
- Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activityAnne von Thun
The Beatson Institute for Cancer Research, Glasgow, United Kingdom
Mol Cell Biol 33:4526-37. 2013..Using mass spectrometry-based proteomics, we identified guanine exchange factor H1 (GEF-H1) as mediating this effect...
- Non-centrosomal microtubules regulate F-actin organization through the suppression of GEF-H1 activityShigenori Nagae
RIKEN Center for Developmental Biology, 2 2 3 Chuo ku, Kobe, 650 0047, Japan
Genes Cells 18:387-96. 2013..In these cells, RhoA activity was upregulated, and the soluble fraction of GEF-H1, a RhoGEF whose activity is inhibited by binding to microtubules, increased, explaining why stress fiber ..
- p40 (ΔNp63) expression in breast disease and its correlation with p63 immunohistochemistrySang Kyum Kim
Department of Pathology, Severance Hospital, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine South Korea
Int J Clin Exp Pathol 7:1032-41. 2014..profiles of p63 protein in benign proliferative diseases and malignant tumors of the breast using pan-p63 and p40 antibodies, and analyze their diagnostic utility and clinical implications...
- Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functionsSylvie Urbé
Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom
Mol Biol Cell 23:1095-103. 2012....
- Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1Yun Zhao
Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Inflamm Bowel Dis 18:603-12. 2012..Genetic variants of nucleotide-binding oligomerization domain 2 (NOD2) lead to aberrant microbial recognition and can cause chronic inflammatory diseases in patients with Crohn's disease (CD)...
- Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activityMadhu Mahankali
Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA
J Biol Chem 287:41417-31. 2012We have demonstrated that phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for Rac2 and determined the PLD2 domains and amino acid site(s) responsible for its GEF activity...
- Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on RasKaren M Henkels
Wright State University School of Medicine, Department of Biochemistry and Molecular Biology, OH 45435, USA
Cell Signal 25:198-205. 2013..e., is a GEF), with potency comparable to Ras-GRF-1, a known Ras-GEF...
- p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humansA Poggi
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
Eur J Immunol 25:369-76. 1995..with molecules with an apparent molecular mass of 40 kDa under both reducing and nonreducing conditions ("p40" molecules), thus differing from CD45 or CD11a/CD18 antigens as well as from the "inhibitory" ..
- Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cellsChristoph Becker
Laboratory of Immunology I, Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 112:693-706. 2003IL-12 p40-related cytokines such as IL-12 p35/p40 heterodimer and IL-23 (p19/p40) are potent regulators of adaptive immune responses. Little is known, however, about the transcriptional regulation of the p40 gene in vivo...
- Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteinsS E Plevy
Howard Hughes Medical Institute and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90095 1662, USA
Mol Cell Biol 17:4572-88. 1997..The gene for the IL-12 p40 subunit is expressed in macrophages following induction by bacterial products, and its expression is augmented by ..
- Tissue-preserving antibody cocktails to differentiate primary squamous cell carcinoma, adenocarcinoma, and small cell carcinoma of lungAlan F Brown
Department of Pathology, University of Texas Health Science Center at San Antonio, 78229, USA
Arch Pathol Lab Med 137:1274-81. 2013..The limitations of small sample size and the need to conserve tissue for additional molecular studies necessitate the use of sensitive and specific marker panels on a single slide...
- The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine productionRashmi Jalah
Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702 1201, USA
J Biol Chem 288:6763-76. 2013IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits...
- Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cellsRen Xi Wang
Molecular Immunology Section, Laboratory of Immunology, NEI, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
J Biol Chem 287:36012-21. 2012..In this study, we have genetically engineered a novel IL27p28/IL12p40 heterodimeric cytokine (p28/p40) that antagonizes signaling downstream of the gp130 receptor...
- p40 (ΔNp63) and keratin 34βE12 provide greater diagnostic accuracy than p63 in the evaluation of small cell lung carcinoma in small biopsy samplesKelly J Butnor
The University of Vermont Fletcher Allen Health Care, Burlington, VT 05401, USA
Hum Pathol 44:1479-86. 2013..b>p40 (ΔNp63) has recently been purported to be a highly specific marker for squamous cell lung carcinoma, but data ..
- Controversies concerning pathophysiology and management of acalculous biliary-type abdominal painAmit Rastogi
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Dig Dis Sci 50:1391-401. 2005..Cholecystokinin cholescintigraphy to measure the gallbladder ejection fraction (GEF) has been advocated as a criterion for cholecystectomy...
- Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cellsMasato Eitaki
Department of Environmental Veterinary Sciences, Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
BMC Cancer 12:469. 2012..In this study, using four different anti-cancer drugs (vincristine, paclitaxel, cisplatin and etoposide), we examined whether these drugs influence the invasive ability of tumor cells...
- Photopic visual input is necessary for emmetropization in miceTatiana V Tkatchenko
Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI 48201, United States
Exp Eye Res 115:87-95. 2013..5 ± 1.3 D at P32 and, and did not change significantly until P40 (+0.3 ± 0.6 D, P40). Animals in this group became progressively hyperopic between P40 and P89 (+2.2 ± 0...
- Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signallingY C Liao
Institute of Medical Science, Tzu Chi University, Hualien, Taiwan
Oncogene 31:3086-97. 2012..Here, we showed that Rho guanine nucleotide exchange factor-H1 (GEF-H1) was transcriptionally activated by hPTTG1, thereby promoting breast cancer metastasis...
- The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytesNorihiko Ohbayashi
Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai, Miyagi 980 8578, Japan
Mol Biol Cell 23:669-78. 2012..Although Varp contains a Rab21-guanine nucleotide exchange factor (GEF) domain (i.e...
- Regulation of Kalirin by Cdk5Xiaonan Xin
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
J Cell Sci 121:2601-11. 2008..Expression of Kalirin-7 in nondifferentiated PC12 cells caused GEF-activity-dependent extension of broad cytoplasmic protrusions; coexpression of dominant-negative Cdk5 largely ..
- IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophagesMalabendu Jana
Department of Neurological Sciences, Rush University Medical Center, Cohn Research Building, Suite 320, 1735 West Harrison St, Chicago, IL 60612, United States
Mol Immunol 46:773-83. 2009..The present study underlines the importance of IL-12 p40 homodimer (p40(2)), the so-called biologically inactive molecule, in inducing the expression of IL-16 in primary ..
- Diagnostic value of interleukin-12 p40 in tuberculous pleural effusionsL Valdes
Pulmonology Service, Complejo Hospitalario Clínico Universitario de Santiago, Santiago de Compostela, Spain
Eur Respir J 33:816-20. 2009..deaminase (ADA), ADA isoform ADA-2, interferon (IFN)-gamma, CD3(+)/DR(+) T-lymphocytes and interleukin (IL)-12 p40 were determined in all 96 effusions...
- GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeabilityEli Kakiashvili
Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and Department of Surgery, University of Toronto, Ontario M5B 1W8, Canada
J Biol Chem 284:11454-66. 2009..Mass spectrometry analysis of the RhoG17A-precipitated proteins identified GEF-H1 as a TNF-alpha-activated Rho GEF...
- Role of cytokine p40 family in multiple sclerosisS Brahmachari
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Minerva Med 99:105-18. 2008Over the last couple of decades of neuro-immunological research, the p40 family of cytokines has emerged out as one of the most intriguing areas of interest because of multi-faceted roles of these cytokine in immune-modulation and ..
- The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12Patrick J Lupardus
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Mol Biol 382:931-41. 2008..IL-23 is a binary complex of a four-helix bundle cytokine (p19) and a soluble class I cytokine receptor p40. IL-12 and IL-23 share p40 as an alpha-receptor subunit, yet show only 15% sequence homology between their four-..
- Regulation of GLUT4 expression in denervated skeletal muscleEllis B Jensen
Department of Biology, Viterbo University, La Crosse, Wisconsin, USA
Am J Physiol Regul Integr Comp Physiol 296:R1820-8. 2009..to decreased activation of the transcription factors myocyte enhancer factor 2 (MEF2) and GLUT4 enhancer factor (GEF), which are required for normal GLUT4 expression...
- The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrinsChristophe Guilluy
Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Nat Cell Biol 13:722-7. 2011..biochemical and biophysical approaches, we identified two guanine nucleotide exchange factors (GEFs), LARG and GEF-H1, as key molecules that regulate the cellular adaptation to force...
- A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180Xin Wu
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States
Biochemistry 50:1070-80. 2011..Two metazoan families of GEFs have been described: Dbl-GEF family members that share conserved Dbl homology (DH) and Pleckstrin homology (PH) domains and the more recently ..
- PIN polarity regulation by AGC-3 kinases and ARF-GEF: a recurrent theme with context dependent modifications for plant development and responsePankaj Dhonukshe
Department of Biology, Utrecht University, Utrecht, The Netherlands
Plant Signal Behav 6:1333-7. 2011..findings suggest that two categories of molecules, namely AGC-3 kinase family members PINOID, WAG1, WAG2 and ARF-GEF family member GNOM predominantly influence the polar localization of PINs...
- Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumabJinquan Luo
Centocor Research and Development, Inc, 145 King of Prussia Road, Radnor, PA 19087, USA
J Mol Biol 402:797-812. 2010Interleukin (IL)-12 and IL-23 are heterodimeric proinflammatory cytokines that share a common p40 subunit, paired with p35 and p19 subunits, respectively...
- Diverse Roles for RIC8 During G Protein Signaling in FungiKatherine A Borkovich; Fiscal Year: 2012..Loss of ric8 leads to reduced levels of G proteins in Drosophila, suggesting a chaperone function in addition to GEF activity. RIC8 is absent from plants, protists and the yeast Saccharomyces cerevisiae...
- Rac GTPase signaling during embryonic salivary gland branching morphogenesisSharon Sequeira; Fiscal Year: 2012..used in proposal: 2D, two-dimensional;3D, three-dimensional;BM, basement membrane;ECM, extracellular matrix;GEF, guanine nucleotide exchange factor;GTPase, guanosine triphosphate hydroxylase;IB, immunoblotting;IF, ..
- ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAEKalipada Pahan; Fiscal Year: 2009..We have discovered a new group of inducers of NF-kappaB activation [interleukin-12 (IL-12) p40 homodimer (p40-2) and monomer (p40)] in glial cells. It was known that p40-2 and p40 were biologically inactive...
- Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouseRichard E Mains; Fiscal Year: 2012..Deficits in expression of Kalirin, a large, dual Rho GEF protein, are associated with increased iNOS levels in Alzheimer's disease brain and with decreased spine ..
- STRUCTURE AND FUNCTION OF PAXILLINChristopher E Turner; Fiscal Year: 2012..This will be combined with biochemical analysis of changes in intracellular signaling to include GEF activity assays, protein phosphorylation profiling and protein- protein interactions...
- Signaling Connections Controlling Cell Motility and InvasionDavid D Schlaepfer; Fiscal Year: 2013..will focus on the molecular interactions of focal adhesion kinase (FAK) and a guanine nucleotide exchange factor (GEF) for Rho-family GTPases termed ARHGEF28 (alternative names are p190RhoGEF or Rgnef)...
- Protein Kinase C Signaling Mechanisms in CancerAlan P Fields; Fiscal Year: 2013..cell proliferation and invasion in vitro, and tumor formation in vivo;2) the guanine nucleotide exchange factor (GEF) Ect2 binds the PKC?/Par6 complex and activates Rac1, a key downstream effector of this complex;3) PKC? regulates ..
- Anti-IL-12p40 Treatment of CVID Enteropathy: Gene Expression/Microbiota AnalysisWarren Strober; Fiscal Year: 2013..Ustekinumab is a monoclonal antibody to the p40 subunit of interleukin-12/23...
- Novel Molecules in Calcium Signaling in PlateletsWolfgang Bergmeier; Fiscal Year: 2013..CD-GEF proteins are guanine nucleotide exchange factors for Ras family small GTPases...
- Multimeric Signaling Complexes in PRLr TransductionCharles V Clevenger; Fiscal Year: 2013..binding of ligand, a complex of the Nek3 serine/threonine kinase and the Vav2 guanine nucleotide exchange factor (GEF) associates with the PRLr...
- Role of p190RhoGEF (Rgnef) in cell motility and tumor progressionNichol L G Miller; Fiscal Year: 2013..Rgnef is a 190 kDa RhoA-specific GEF (also termed p190RhoGEF) involved in the regulation of integrin-initiated RhoA activation, focal adhesion (FA) ..
- A Bifunctional Katp Channel Activator and Redox Mimetic for BPDKanneganti Murthy; Fiscal Year: 2013..including eotaxin, G-CSF, GM-CSF, IFN-?, IL-1[unreadable], IL-2, IL4, IL-3, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1[unreadable], MIP-1[unreadable], ..
- Protective role of ANP in the models of acute lung injuryAnna Birukova; Fiscal Year: 2013..microtubule stabilization and regulation of microtubule-associated Rho-specific guanine nucleotide exchange factor GEF-H1...
- Role of Ypt/Rab GTPases in intra-cellular TraffickingNava Segev; Fiscal Year: 2013..Based on our results, we propose that activation of these Ypts is achieved by one modular GEF complex, TRAPP, which thereby coordinates steps of the exocytic pathway as well as its intersection with autophagy...
- Regulation of androgen receptor activity in prostate cancer cells in an aged mousSTEPHANIE OLGA PEACOCK; Fiscal Year: 2013..activity requires the Vav3 pleckstrin homology (PH) domain, but not guanine nucleotide exchange factor (GEF) activity...
- ErbB receptor signaling via small G-proteins in breast cancerMARCELO GABRIEL KAZANIETZ; Fiscal Year: 2013..revealed a prominent role for phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchanger-1 (P-Rex1), a Rac-GEF originally identified in neutrophils but not studied in any cancer so far...
- PLD2, as a GEF or as a Lipase, is Central to Leukocyte ChemotaxisJULIAN G CAMBRONERO; Fiscal Year: 2013..1) First, novel data in our lab has revealed an unexpected GEF activity that exists in the lipase PLD2...
- Rac GTPase-Specific Small Molecular InhibitorsYi Zheng; Fiscal Year: 2013..The GEF-Rac signaling axis lies in the crossroads of many signaling events initiated by growth factors, cytokines, stress, ..
- BARRIER FUNCTION OF THE GI TRACT IN HEALTH AND DISEASEW Allan Walker; Fiscal Year: 2013..Project 4 will determinethe role of GEF-H1, a guanine nucleotide exchange factor (GEF) for Rho, on epithelial cell responses to pathogens and examine the ..
- Molecular Mechanisms of RhoA-mediated Ca2+Sensitization in Vascular Smooth MuscleAvril V Somlyo; Fiscal Year: 2013..data, which postulates that negative control is exerted on RhoA by cyclic nucleotides (cAMP) acting via the Rap1 GEF, Epac and Rap1 (another GTPase) to activate RhoA specific GAPs including ARAP3 and RA-RhoGAP...
- Targeting the Fn14-Rac1 signaling pathway in invasive gliomasNhan L Tran; Fiscal Year: 2012..We found that Ect2, a guanine nucleotide exchange factor (GEF), is overexpressed in GBM, and that overexpression of both Ect2 and Fn14 is correlated directly with tumor grade ..
- Yale Autoimmunity Center of ExcellenceKevan C Herold; Fiscal Year: 2013..The second trial is a Phase II trial of the anti-p40 mAb CNTO 1275 (Ustekinumab) for treatment of primary Sj"gren's syndrome...
- Mechanism of G protein Activation by Ric-8AStephen R Sprang; Fiscal Year: 2013..Ric-8A is critical regulator of G? in this process. Ric-8A is a Guanine nucleotide Exchange Factor (GEF) that catalyzes the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) at the active site of ..
- Probiotics-derived soluble proteins regulate intestinal inflammationFang Yan; Fiscal Year: 2013..We have successfully purified and cloned two novel LGG-derived soluble proteins (p40 and p75) that prevent cytokine-induced apoptosis through activating Akt in intestinal epithelial cells...
- MOLECULAR REGULATION OF INTERLEUKIN 12 GENE EXPRESSIONXiaojing Ma; Fiscal Year: 2003..IL-12 is a heterodimer consisted to two subunits, p40 and p35 that are encoded on different human chromosomes...
- Pairing of EBI-3 and IL12 p35 To Yield A Novel Regulatory T cell CytokineLAUREN COLLISON; Fiscal Year: 2009Epstein barr virus induced gene 3 (EBI-3) is a soluble protein that shares structural similarities to the IL12 p40 chain...
- MECHANISMS & REGULATION OF PROTEIN SYNTHESISALBERT WAHBA; Fiscal Year: 1992The guanine nucleotide exchange factor (GEF) from rabbit reticulocytes which consists of five subunits will be further purified (Proc. Natl. Acad. Sci. U.S.A...
- SIGNALING VIA THE MULTIFUNCTIONAL TRIO PROTEINHaruo Saito; Fiscal Year: 2001..The multifunctional Trio protein contains a rac1-specific GEF domain, a rhoA-specific GEF domain, a protein serine\threonine kinase domain, and a number of auxiliary domains...
- RHOA EFFECTOR IN HIV-1 REPLICATION AND PATHOGENESISLishan Su; Fiscal Year: 2004..gp41 (gp41C) interacts with and inhibits p115-RhoGEF, which is a specific guanine nucleotide exchange factor (GEF) and activator of RhoA...
- NOVEL SECOND MESSENGER SIGNALING IN THE STRIATUMANN GRAYBIEL; Fiscal Year: 2003..Many Ras GEFs, but until the work described, only Rap GEF, have been identified...
- FUNCTION OF THE VAV PROTOONCOGENEArthur Weiss; Fiscal Year: 2004..The Vav family of proteins contains multiple modular domains including a guanine nucleotide exchange factor (GEF) domain that can regulate small GTPases of the Rho family...