Gene Symbol: ARHGAP18
Description: Rho GTPase activating protein 18
Alias: MacGAP, SENEX, bA307O14.2, rho GTPase-activating protein 18, rho-type GTPase-activating protein 18
Species: human
Products:     ARHGAP18

Top Publications

  1. Zeng X, Vonk J, van der Plaat D, Faiz A, Pare P, Joubert P, et al. Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms. Environ Int. 2019;122:263-269 pubmed publisher
    ..Several identified loci were plausible candidates for respiratory symptoms, such as TMPRSS9, SERPINH1, TOX3, and ARHGAP18. Three replicated SNPs were cis-eQTLs for FCER1A, CHN1, and TIMM13 in lung tissue...
  2. Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, et al. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature. 2015;521:217-221 pubmed publisher
    ..By analysing YAP function in 3D spheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of YAP in controlling tissue tension...
  3. Vautrin Glabik A, Botia B, Kischel P, Ouadid Ahidouch H, Rodat Despoix L. IP3R3 silencing induced actin cytoskeletal reorganization through ARHGAP18/RhoA/mDia1/FAK pathway in breast cancer cell lines. Biochim Biophys Acta Mol Cell Res. 2018;1865:945-958 pubmed publisher
    ..Moreover, IP3R3 silencing decreased ARHGAP18 expression, RhoA activity, Cdc42 expression and Y861FAK phosphorylation...
  4. Asai A, Karnan S, Ota A, Takahashi M, Damdindorj L, Konishi Y, et al. High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas. Gene. 2015;558:220-6 pubmed publisher
    ..1 (67%, CHCHD4), 4p15.32 (56%, FGFBP1), 5q11.2 (56%, ARL15), 6q22.31 (56%, NKAIN2), 6q22.33 (67%, ARHGAP18), 6q25.1 (67%, UST), 7q13 (56%, ADCY1), 12q13.13 (44%, KRT71), 19q13.32 (56%, GRLF1), and 20p11...
  5. Wang L, Yao Z, Moorman J, Xu Y, Ning S. Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies. PLoS ONE. 2014;9:e106788 pubmed publisher the context of EBV latent infection, and confirmed several genes including IFI27, IFI44, GBP1, and ARHGAP18, as well as CFLAR as novel targets for IRF4...
  6. Matthaei M, Zhu A, Kallay L, Eberhart C, Cursiefen C, Jun A. Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy. Exp Eye Res. 2014;129:13-7 pubmed publisher
    ..In addition, increased expression of CDKN2A and its transcriptional activators ETS1 and ARHGAP18 (SENEX) along with decreased expression of CDKN2A inhibitor ID1 were detected in FECD samples...
  7. Wu Z, Wu Q, Xu J, Chen S, Sun F, Li P, et al. HLA-DPB1 variant rs3117242 is associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese population. Int J Rheum Dis. 2017;20:1009-1015 pubmed publisher
    ..We investigated the linkage between putative AAV-related genes (HLA-DPB1, ARHGAP18, CD226, CTLA-4, MOSPD2 and PRTN3) and AAV in a Han Chinese population...
  8. Aguilar Rojas A, Maya Nunez G, Huerta Reyes M, Pérez Solis M, Silva García R, Guillen N, et al. Activation of human gonadotropin-releasing hormone receptor promotes down regulation of ARHGAP18 and regulates the cell invasion of MDA-MB-231 cells. Mol Cell Endocrinol. 2018;460:94-103 pubmed publisher
    ..human GnRHR is able to diminish the expression and therefore functions of the Rho GTPase-Activating Protein 18 (ARHGAP18)...
  9. Liu R, Lo L, Lay A, Zhao Y, Ting K, Robertson E, et al. ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype. Circ Res. 2017;121:512-524 pubmed publisher
    ..Here we explore the role of ARHGAP18, a novel Rho GAP expressed by smooth muscle cells (SMCs), in the pathogenesis of TAA...

More Information


  1. Thompson W, Yen S, Uzer G, Xie Z, Sen B, Styner M, et al. LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage. Bone. 2018;107:172-180 pubmed publisher
    ..Knockdown of ARHGAP18 increased basal RhoA activity and actin stress fiber formation, but did not enhance mechanical strain activation ..
  2. Maeda M, Hasegawa H, Hyodo T, Ito S, Asano E, Yuang H, et al. ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. Mol Biol Cell. 2011;22:3840-52 pubmed publisher
    ..We studied the role of a previously uncharacterized GAP, ARHGAP18 (MacGAP). Overexpression of ARHGAP18 suppressed the activity of RhoA and disrupted stress fiber formation...
  3. Coleman P, Hahn C, Grimshaw M, Lu Y, Li X, Brautigan P, et al. Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood. 2010;116:4016-24 pubmed publisher
    ..We describe here the identification of a novel gene, SENEX, that regulates stress induced premature senescence pathways in endothelial cells (ECs) involving p16(INK4a) and ..
  4. Cronin S, Tomik B, Bradley D, Slowik A, Hardiman O. Screening for replication of genome-wide SNP associations in sporadic ALS. Eur J Hum Genet. 2009;17:213-8 pubmed publisher
    ..The result for DPP6 is surprising, as it has been replicated elsewhere. We discuss the possible interpretations and implications of these findings for future ALS GWA studies both within and between populations. ..
  5. Shaffer J, Polk D, Wang X, Feingold E, Weeks D, Lee M, et al. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. G3 (Bethesda). 2014;4:307-14 pubmed publisher
    ..Though small, efforts such this are needed in order to nominate novel genes and generate new hypotheses for exploration and testing in future studies. ..
  6. Guo W, Cai Y, Zhang H, Yang Y, Yang G, Wang X, et al. Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population. PLoS ONE. 2017;12:e0175209 pubmed publisher
    ..The newly identified RhoGAP ARHGAP18 is likely involved in neurodevelopment through regulation of RhoA/C...
  7. Humphries B, Wang Z, Li Y, Jhan J, Jiang Y, Yang C. ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA. Cancer Res. 2017;77:4051-4064 pubmed publisher
    ..Here this expectation was challenged by characterization of ARHGAP18, a RhoGAP family member that is selectively overexpressed in highly migratory triple-negative breast cancer (TNBC)..
  8. He Y, Luo J, Chen Y, Zhou X, Yu S, Jin L, et al. ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in ?-thalassaemia. Mol Genet Genomics. 2018;293:207-216 pubmed publisher
    ..A total of 1141 subjects with ?-thalassaemia were recruited. The results showed that the SNP rs11759328 in the ARHGAP18 gene was significantly associated with HbF levels (? = 5.1 × 10-4)...
  9. Lovelace M, Powter E, Coleman P, Zhao Y, Parker A, Chang G, et al. The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. Mol Biol Cell. 2017;28:1066-1078 pubmed publisher
    ..Previously we showed that ARHGAP18 in endothelial cells is important in cell junctions...
  10. Potkin S, Turner J, Fallon J, Lakatos A, Keator D, Guffanti G, et al. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol Psychiatry. 2009;14:416-28 pubmed publisher
    We have discovered two genes, RSRC1 and ARHGAP18, associated with schizophrenia and in an independent study provided additional support for this association...
  11. Lyons P, Rayner T, Trivedi S, Holle J, Watts R, Jayne D, et al. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med. 2012;367:214-23 pubmed publisher
    ..These data provide preliminary support for the concept that proteinase 3 ANCA-associated vasculitis and myeloperoxidase ANCA-associated vasculitis are distinct autoimmune syndromes. (Funded by the British Heart Foundation and others.). ..
  12. Cox A, Hugenschmidt C, Raffield L, Langefeld C, Freedman B, Williamson J, et al. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging. 2014;35:1958.e3-1958.e12 pubmed publisher
  13. Huang S, Zhao Z, Weng G, He X, Wu C, Fu C, et al. The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. Int J Oncol. 2016;49:217-24 pubmed publisher
    ..Our results show that miR-181a is down-regulated in GBM patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a...
  14. Chang G, Lay A, Ting K, Zhao Y, Coleman P, Powter E, et al. ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small Gtpases. 2014;5:1-15 pubmed publisher
    ..Here, we have identified a novel gene, ARHGAP18, as an endogenous negative regulator of angiogenesis, limiting pro-angiogenic signaling and promoting vascular ..