Gene Symbol: ARH
Description: low density lipoprotein receptor adaptor protein 1
Alias: ARH, ARH1, ARH2, FHCB1, FHCB2, low density lipoprotein receptor adapter protein 1, LDL receptor adaptor protein, autosomal recessive hypercholesterolemia protein
Species: human
Products:     ARH

Top Publications

  1. He G, Gupta S, Yi M, Michaely P, Hobbs H, Cohen J. ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. J Biol Chem. 2002;277:44044-9 pubmed
    Mutations in the phosphotyrosine binding domain protein ARH cause autosomal recessive hypercholesterolemia, a disorder caused by defective internalization of low density lipoprotein receptors (LDLR) in the liver...
  2. Mishra S, Watkins S, Traub L. The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery. Proc Natl Acad Sci U S A. 2002;99:16099-104 pubmed
    ..a recessive pattern of inheritance, and several genetic lesions in the autosomal recessive hypercholesterolemia (ARH) gene on chromosome 1 have been mapped in this class of patients...
  3. Nagai M, Meerloo T, Takeda T, Farquhar M. The adaptor protein ARH escorts megalin to and through endosomes. Mol Biol Cell. 2003;14:4984-96 pubmed
    ..The cytoplasmic tail of megalin contains two FXNPXY motifs. Autosomal recessive hypercholesterolemia (ARH) is an adaptor protein that binds to the FXNPXY motif of the low-density lipoprotein receptor as well as clathrin ..
  4. Mishra S, Keyel P, Edeling M, Dupin A, Owen D, Traub L. Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. J Biol Chem. 2005;280:19270-80 pubmed
    The autosomal recessive hypercholesterolemia (ARH) protein plays a critical role in regulating plasma low density lipoprotein (LDL) levels...
  5. Badri H, Monsieurs P, Coninx I, Nauts R, Wattiez R, Leys N. Temporal Gene Expression of the Cyanobacterium Arthrospira in Response to Gamma Rays. PLoS ONE. 2015;10:e0135565 pubmed publisher
    ..Additionally, the exposed cells showed significant increased expression of arh genes, coding for a novel group of protein of unknown function, also seen in our previous irradiation studies...
  6. Briski K, Shrestha P. Hindbrain estrogen receptor-beta antagonism normalizes reproductive and counter-regulatory hormone secretion in hypoglycemic steroid-primed ovariectomized female rats. Neuroscience. 2016;331:62-71 pubmed publisher
    ..caused PHTPP-reversible changes in NE and prepro-kisspeptin protein content in the hypothalamic arcuate (ARH), but not anteroventral periventricular nucleus...
  7. Cady G, Landeryou T, Garratt M, Kopchick J, Qi N, García Galiano D, et al. Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab. 2017;6:393-405 pubmed publisher
    ..Our results demonstrate that the sites with GHR and LepRb co-expression include ARH, DMH, and LHA neurons...
  8. Fu Y, Chen J, Pang B, Li C, Zhao J, Shen K. EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer. Cell Biochem Biophys. 2015;71:105-12 pubmed publisher
    ..To explore the correlation between EZH2 and ARHI expression in EOC as well as the possible mechanism of EZH2-ARH1 interaction...
  9. Wang C, Cao K, Zhang Y, Fang L, Li X, Xu Q, et al. Different effects of meteorological factors on hand, foot and mouth disease in various climates: a spatial panel data model analysis. BMC Infect Dis. 2016;16:233 pubmed publisher
    ..atmospheric pressure (AAP), average temperature (AT), average vapor pressure (AVP), average relative humidity (ARH), monthly precipitation (MP), average wind speed (AWS), monthly total sunshine hours (MSH), mean temperature ..

More Information

Publications138 found, 100 shown here

  1. Ma Y, Gong Y, Garg A, Zhou H. Compound heterozygous familial hypercholesterolemia in a Chinese boy with a de novo and transmitted low-density lipoprotein receptor mutation. J Clin Lipidol. 2018;12:230-235.e6 pubmed publisher
    ..Our report supports the role of genetic testing in the proband and the parents for accurate genetic counseling. Our patient had marked lowering of LDL-C with a combination of statin and ezetimibe but may require additional therapy. ..
  2. Tamrakar P, Briski K. Estradiol regulation of hypothalamic astrocyte adenosine 5'-monophosphate-activated protein kinase activity: role of hindbrain catecholamine signaling. Brain Res Bull. 2015;110:47-53 pubmed publisher glial fibrillary acidic protein immunolabeling were laser-microdissected from the ventromedial (VMH), arcuate (ARH), and paraventricular (PVH) nuclei and the lateral hypothalamic area (LHA), and pooled within each site for Western ..
  3. Paththinige C, Rajapakse J, Constantine G, Sem K, Singaraja R, Jayasekara R, et al. Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia - a preliminary report. Lipids Health Dis. 2018;17:100 pubmed publisher
  4. Paul A, Drecourt A, Petit F, Deguine D, Vasnier C, Oufadem M, et al. FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases. Am J Hum Genet. 2017;101:630-637 pubmed publisher
    ..Functional complementation in a yeast strain in which ARH1, the human FDXR ortholog, was deleted established the pathogenicity of these mutations...
  5. Hovingh G, Goldberg A, Moriarty P. Managing the challenging homozygous familial hypercholesterolemia patient: Academic insights and practical approaches for a severe dyslipidemia, a National Lipid Association Masters Summit. J Clin Lipidol. 2017;11:602-616 pubmed publisher
    ..LDL receptor gene, variants in the apolipoprotein B, proprotein convertase subtilisin kexin type 9, or LDL receptor adaptor protein gene loci can also be causative...
  6. Alvarez M, Khosroheidari M, Eddy E, Done S. MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis. Atherosclerosis. 2015;242:595-604 pubmed publisher
    ..The results presented here provide evidence supporting the potential of miR-27a as a novel therapeutic target for the prevention of atherosclerosis. ..
  7. Mohd Nor N, Al Khateeb A, Chua Y, Mohd Kasim N, Mohd Nawawi H. Heterozygous familial hypercholesterolaemia in a pair of identical twins: a case report and updated review. BMC Pediatr. 2019;19:106 pubmed publisher
    ..Therefore, childhood FH can be diagnosed early using a combination of clinical criteria and molecular analyses. ..
  8. Balland E, Chen W, Dodd G, Conductier G, Coppari R, Tiganis T, et al. Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell Rep. 2019;26:346-355.e3 pubmed publisher
    ..We demonstrate that the central pharmacological inhibition or ARH-targeted deletion of PTP1B restores the suppression of HGP in obese mice...
  9. Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron J, et al. PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. J Lipid Res. 2015;56:2133-42 pubmed publisher
    ..E2) treatment restored the female pattern without concomitant changes in LDLR adaptor protein 1 (also known as ARH), disabled-2, or inducible degrader of the LDLR expression levels...
  10. Gabcova Balaziova D, Staníková D, Vohnout B, Huckova M, Stanik J, Klimes I, et al. Molecular-genetic aspects of familial hypercholesterolemia. Endocr Regul. 2015;49:164-81 pubmed genes encoding LDL receptor, apolipoprotein B, proprotein convertase subtilisin/kexin 9 and LDL receptor adaptor protein 1...
  11. Sohn J. Network of hypothalamic neurons that control appetite. BMB Rep. 2015;48:229-33 pubmed
    ..Specifically, two distinct neuronal populations exist in the arcuate nucleus of hypothalamus (ARH): the anorexigenic (appetite-suppressing) pro-opiomelanocortin (POMC) neurons and the orexigenic (appetite-..
  12. Corral P, Geller A, Polisecki E, López G, Bañares V, Cacciagiú L, et al. Unusual genetic variants associated with hypercholesterolemia in Argentina. Atherosclerosis. 2018;277:256-261 pubmed publisher
  13. Hayashi K, Milloy M, Wood E, Dong H, Montaner J, Kerr T. Predictors of liver-related death among people who inject drugs in Vancouver, Canada: a 15-year prospective cohort study. J Int AIDS Soc. 2014;17:19296 pubmed publisher
    ..HCV seropositivity was not significantly associated with liver-related mortality (adjusted relative hazard [ARH]: 0.45; 95% CI: 0.15-1.37), but HIV seropositivity was (ARH: 2.67; 95% CI: 1.27-5.63)...
  14. Cao Y, Wu N, Sun D, Liu H, Jin J, Li S, et al. Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease. J Transl Med. 2018;16:345 pubmed publisher
    ..56 mmol/L. The underdiagnostic rate of clinical criteria was around 42.5-62.5%, suggesting that the expanded genetic testing could indeed promote the diagnosis of FH. ..
  15. Kumar H, Frischknecht F, Mair G, Gomes J. In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage. Infect Genet Evol. 2015;36:72-81 pubmed publisher
    ..these are: fabB/F, fabI, arp, 3 genes encoding subunits of the PDH complex, dnaJ, urm1, rS5, ancp, mcp, arh, gk, lisp2, valS, palm, and four conserved Plasmodium proteins of unknown function...
  16. Tada H, Kawashiri M, Nomura A, Teramoto R, Hosomichi K, Nohara A, et al. Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease. J Clin Lipidol. 2018;12:1436-1444 pubmed publisher
    ..convertase subtilisin/kexin type 9) and 4 LDL-altering accessory genes (ABCG5, ABCG8, APOE, and LDL receptor adaptor protein 1)...
  17. Madeddu G, Rusconi S, Cozzi Lepri A, Di Giambenedetto S, Bonora S, Carbone A, et al. Efficacy and tolerability of switching to a dual therapy with darunavir/ritonavir plus raltegravir in HIV-infected patients with HIV-1 RNA ≤50 cp/mL. Infection. 2017;45:521-528 pubmed publisher
    ..Female gender (adjusted relative hazard, ARH = 0.10; 95% CI 0.01-0.74; p = 0.024) and older age (AHR = 0.50 per 10 years older; 95% CI 0...
  18. Zuidema A, Wang W, Kreft M, Te Molder L, Hoekman L, Bleijerveld O, et al. Mechanisms of integrin αVβ5 clustering in flat clathrin lattices. J Cell Sci. 2018;131: pubmed publisher
    ..FCLs requires the presence of vitronectin as ligand, Ca2+, and the clathrin adaptor proteins ARH (also known as LDLRAP1), Numb and EPS15/EPS15L1...
  19. Allan C, Awad A, Johnson J, Shirasaki D, Wang C, Blaby Haas C, et al. Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae. J Biol Chem. 2015;290:7517-34 pubmed publisher
    ..In the yeast Saccharomyces cerevisiae, Q is synthesized by the products of 11 known genes, COQ1-COQ9, YAH1, and ARH1. The function of some of the Coq proteins remains unknown, and several steps in the Q biosynthetic pathway are not ..
  20. Scotece M, Gomez R, Conde J, Lopez V, Gomez Reino J, Lago F, et al. Oleocanthal inhibits proliferation and MIP-1α expression in human multiple myeloma cells. Curr Med Chem. 2013;20:2467-75 pubmed
    ..a recently isolated novel extra virgin olive oil polyphenol, oleocanthal, on the human multiple myeloma cell line ARH-77...
  21. Momtazi A, Banach M, Pirro M, Stein E, Sahebkar A. MicroRNAs: New Therapeutic Targets for Familial Hypercholesterolemia?. Clin Rev Allergy Immunol. 2018;54:224-233 pubmed publisher
    ..The present review describes miRs-targeting FH-associated genes that could be used as potential therapeutic targets in patients with FH or other severe dyslipidemias. ..
  22. Henderson R, O Kane M, McGilligan V, Watterson S. The genetics and screening of familial hypercholesterolaemia. J Biomed Sci. 2016;23:39 pubmed publisher
    ..However, the cost of sequencing patient DNA has fallen dramatically in recent years and if the rate of progress continues, this may change. ..
  23. Tada H, Kawashiri M, Takata M, Matsunami K, Imamura A, Matsuyama M, et al. Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding. JIMD Rep. 2015;21:115-22 pubmed publisher
    ..for low-density lipoprotein (LDL) receptor, proprotein convertase subtilisin/kexin type 9 (PCSK9), LDL receptor adaptor protein 1 and ATP-binding cassette (ABC) subfamily G member 5 and 8 (ABCG5 and ABCG8) genes...
  24. Wang C, Zhao C, Liu L, Wu R, Zhang X. Expression patterns of Doppel in differential ovine PRNP genotypes: quantification using real-time RT-PCR. Genet Mol Res. 2015;14:12152-8 pubmed publisher
    ..of lymphoid system, eleven regions of digestive tract and two reproductive organs from four ARR/ARQ and four ARH/ARQ sheep, genotypes of the PrP gene...
  25. Blanco Vaca F, Martín Campos J, Perez A, Fuentes Prior P. A rare STAP1 mutation incompletely associated with familial hypercholesterolemia. Clin Chim Acta. 2018;487:270-274 pubmed publisher
    ..Our findings confirm and extend the linkage between STAP1 variants and FH, and point to an important role of this adaptor protein within a signaling pathway that affects cholesterol homeostasis. ..
  26. Hou D, He F, Ma L, Cao M, Zhou Z, Wei Z, et al. The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells. J Nutr Biochem. 2018;57:197-205 pubmed publisher
    ..These findings offer a novel vasoprotective molecular mechanism of green veggies through plant microRNAs. ..
  27. Arensman M, Nguyen P, Kershaw K, Lay A, Ostertag Hill C, Sherman M, et al. Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Mol Cancer Res. 2015;13:1509-19 pubmed publisher
  28. Rack J, Ariza A, Drown B, Henfrey C, Bartlett E, Shirai T, et al. (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Cell Chem Biol. 2018;25:1533-1546.e12 pubmed publisher
    ..Here we present a comprehensive structural analysis of the enzymatically active family members ARH1 and ARH3. These two enzymes have very distinct substrate requirements...
  29. Sharber S, Shih K, Mann A, Frausto F, Haas T, Nieh M, et al. Reversible mechanofluorochromism of aniline-terminated phenylene ethynylenes. Chem Sci. 2018;9:5415-5426 pubmed publisher
    ..phases of these materials have PE chromophores that are twisted due to non-covalent perfluoroarene-arene (ArF-ArH) interactions involving perfluorophenyl pendants and the terminal rings of the PE chromophore, resulting in ..
  30. Stanisz B, Paszun S, Strzyzycka N, Ptaszyński E. Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. Acta Pol Pharm. 2010;67:99-102 pubmed
    ..The effect of humidity on QHCl stability in the presence of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate was linear and according to the equation ln k(i) = aRH% + b.
  31. Fahy E, McCarthy E, Steinhagen Thiessen E, Vaughan C. A case of autosomal recessive hypercholesterolemia responsive to proprotein convertase subtilisin/kexin 9 inhibition. J Clin Lipidol. 2017;11:287-288 pubmed publisher
    ..We report the first case of hypercholesterolemia due to autosomal recessive hyperlipidemia caused by LDLRAP1 mutation responding favorably to PCSK9 inhibition. ..
  32. van der Sande N, de Beus E, Bots M, Voskuil M, Blankestijn P, Visseren F, et al. Apparent resistant hypertension and the risk of vascular events and mortality in patients with manifest vascular disease. J Hypertens. 2018;36:143-150 pubmed publisher
    Patients with apparent resistant hypertension (aRH) are at increased risk for developing cardiovascular disease...
  33. Wan J, Liu X, Kerr P, Wu C, Wu Y. Comparison of the properties of periphyton attached to modified agro-waste carriers. Environ Sci Pollut Res Int. 2016;23:3718-26 pubmed publisher
    ..Thus, the periphyton attached to modified agro-wastes (DPS, APS, and ARH) grew in a stable and sustainable manner...
  34. Sørensen T, Kilså K, Laursen B. Aminorhodamine (ARh): A Bichromophore with Three Emission Bands in Low Temperature Glasses. Chemistry. 2015;21:8521-9 pubmed publisher
    At first glance, aminorhodamine (ARh) is a typical pH responsive fluorescent, rhodamine-type dye...
  35. Bu X, Kato J, Moss J. Emerging roles of ADP-ribosyl-acceptor hydrolases (ARHs) in tumorigenesis and cell death pathways. Biochem Pharmacol. 2018;: pubmed publisher
    ..Similarly, by cleaving mono-ADP-ribosylated arginine on target proteins, ARH1 appears to inhibit tumor formation, suggesting that ARH1 is a tumor-suppressor gene...
  36. Sadagurski M, Landeryou T, Cady G, Bartke A, Bernal Mizrachi E, Miller R. Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice. Physiol Rep. 2015;3: pubmed publisher
    ..brief period of early food restriction leads to permanent modulation of the arcuate nucleus of the hypothalamus (ARH), markedly increasing formation of both orexigenic agouti-related peptide (AgRP) and anorexigenic ..
  37. Alhamami H, Uddin M, Mahmood A, Briski K. Lateral but not Medial Hypothalamic AMPK Activation Occurs at the Hypoglycemic Nadir in Insulin-injected Male Rats: Impact of Caudal Dorsomedial Hindbrain Catecholamine Signaling. Neuroscience. 2018;379:103-114 pubmed publisher
    ..Micropunched arcuate (ARH), ventromedial (VMH), paraventricular (PVH), dorsomedial (DMH) nuclei and lateral hypothalamic area (LHA) tissues ..
  38. Muntoni S, Pisciotta L, Muntoni S, Bertolini S. Pharmacological treatment of a Sardinian patient affected by Autosomal Recessive Hypercholesterolemia (ARH). J Clin Lipidol. 2015;9:103-6 pubmed publisher
    Previous studies have shown that patients with autosomal recessive hypercholesterolemia (ARH) resulting from mutations in LDLRAP1 gene have a less severe cardiovascular involvement than familial hypercholesterolemia homozygotes, lower ..
  39. Long N, Long B, Mana A, Le D, Nguyen L, Chokr S, et al. Tamoxifen and ICI 182,780 activate hypothalamic G protein-coupled estrogen receptor 1 to rapidly facilitate lordosis in female rats. Horm Behav. 2017;89:98-103 pubmed publisher
    ..metabotropic glutamate receptor 1a to activate β-endorphin neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN)...
  40. Iacocca M, Wang J, Sarkar S, Dron J, Lagace T, McIntyre A, et al. Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia. Can J Cardiol. 2018;34:1316-1324 pubmed publisher
    ..This finding also has therapeutic relevance, as elevated PCSK9 levels may limit the efficacy of high-dose statin therapy and also PCSK9 inhibition. ..
  41. Goedeke L, Rotllan N, Ramírez C, Aranda J, Canfrán Duque A, Araldi E, et al. miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice. Atherosclerosis. 2015;243:499-509 pubmed publisher
    ..The results presented here provide evidence that short-term modulation of miR-27b expression in wild-type mice regulates hepatic LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels. ..
  42. Long N, Serey C, Sinchak K. 17β-estradiol rapidly facilitates lordosis through G protein-coupled estrogen receptor 1 (GPER) via deactivation of medial preoptic nucleus μ-opioid receptors in estradiol primed female rats. Horm Behav. 2014;66:663-6 pubmed publisher
    ..inhibits lordosis through a multi-synaptic circuit originating in the arcuate nucleus of the hypothalamus (ARH) that activates and internalizes μ-opioid receptors (MOR) in medial preoptic nucleus (MPN) neurons...
  43. Mashimo M, Kato J, Moss J. Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases. DNA Repair (Amst). 2014;23:88-94 pubmed publisher
    ..This family comprises three members (ARH1-3) with similar size (39kDa) and amino acid sequence...
  44. Rühl P, Pöll U, Braun J, Klingl A, Kletzin A. A Sulfur Oxygenase from the Haloalkaliphilic Bacterium Thioalkalivibrio paradoxus with Atypically Low Reductase Activity. J Bacteriol. 2017;199: pubmed publisher
    ..showed that the sulfur oxygenase reductase (SOR) of the haloalkaliphilic bacterium Thioalkalivibrio paradoxus Arh 1 (TpSOR) is branching deeply within dendrograms of these proteins (29 to 34% identity)...
  45. Tamrakar P, Shrestha P, Briski K. Dorsomedial hindbrain catecholamine regulation of hypothalamic astrocyte glycogen metabolic enzyme protein expression: Impact of estradiol. Neuroscience. 2015;292:34-45 pubmed publisher
    ..protein immunolabeling were laser-microdissected from the ventromedial hypothalamic (VMH), arcuate hypothalamic (ARH), and paraventricular hypothalamic (PVH) nuclei and the lateral hypothalamic area (LHA) of estradiol (E)- or oil (O)..
  46. Breij L, Mulder M, van Vark van der Zee L, Hokken Koelega A. Appetite-regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. Eur J Nutr. 2017;56:1725-1732 pubmed publisher
    ..Appetite-regulating hormones (ARH) play a role in regulation of food intake and might thus influence body composition in later life...
  47. Buonuomo P, Iughetti L, Pisciotta L, Rabacchi C, Papadia F, Bruzzi P, et al. Timely diagnosis of sitosterolemia by next generation sequencing in two children with severe hypercholesterolemia. Atherosclerosis. 2017;262:71-77 pubmed publisher
    ..diagnosis of homozygous autosomal dominant hypercholesterolemia (ADH), autosomal recessive hypercholesterolemia (ARH) or sitosterolemia, depending on the transmission of hypercholesterolemia in the patient's family...
  48. Pirillo A, Garlaschelli K, Arca M, Averna M, Bertolini S, Calandra S, et al. Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study. Atheroscler Suppl. 2017;29:17-24 pubmed publisher
    ..This study shows the molecular characteristics of the FH patients identified in Italy over the last two years. Full phenotypic characterization of these patients and cascade screening of family members is now in progress. ..
  49. Hartgers M, Defesche J, Langslet G, Hopkins P, Kastelein J, Baccara Dinet M, et al. Alirocumab efficacy in patients with double heterozygous, compound heterozygous, or homozygous familial hypercholesterolemia. J Clin Lipidol. 2018;12:390-396.e8 pubmed publisher
    ..Clinically meaningful LDL-C-lowering activity was observed in patients receiving alirocumab who were double heterozygous, compound heterozygous, or homozygous for genes that are causative for FH. ..
  50. Zimmermann K, Jentsch M, Rasche A, Hummel M, Leser U. Algorithms for differential splicing detection using exon arrays: a comparative assessment. BMC Genomics. 2015;16:136 pubmed publisher
    ..Our studies indicated ARH as the most robust methods when integrating the results over all scenarios and data sets...
  51. Mashimo M, Moss J. ADP-Ribosyl-Acceptor Hydrolase Activities Catalyzed by the ARH Family of Proteins. Methods Mol Biol. 2018;1813:187-204 pubmed publisher
    The ARH family of ADP-ribosyl-acceptor hydrolases is composed of three 39-kDa proteins (ARH1, 2, and 3), which hydrolyze specific ADP-ribosylated substrates...
  52. Piedimonte S, Czuzoj Shulman N, Gotlieb W, Abenhaim H. Robotic Radical Hysterectomy for Cervical Cancer: A Population-Based Study of Adoption and Immediate Postoperative Outcomes in the United States. J Minim Invasive Gynecol. 2019;26:551-557 pubmed publisher
    To compare the use of robotic radical hysterectomy (RRH) and abdominal radical hysterectomy (ARH) in the United States, with secondary outcomes of perioperative complications, hospital length of stay (LOS), immediate postoperative ..
  53. Shazly S, Murad M, Dowdy S, Gostout B, Famuyide A. Robotic radical hysterectomy in early stage cervical cancer: A systematic review and meta-analysis. Gynecol Oncol. 2015;138:457-71 pubmed publisher
    ..Twenty six nonrandomized studies were included (10 RRH vs abdominal radical hysterectomy [ARH], 9 RRH vs laparoscopic radical hysterectomy [LRH] and 7 compared all 3 approaches) enrolling 4013 women (1013 RRH, ..
  54. Gabunia K, Herman A, Ray M, Kelemen S, England R, DeLa Cadena R, et al. Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC. J Mol Cell Cardiol. 2017;105:38-48 pubmed publisher
    ..Mutations in this gene lead to LDL receptor malfunction and cause the Autosomal Recessive Hypercholesterolemia (ARH) disorder in humans...
  55. Lewis N, Howatson G, Morton K, Hill J, Pedlar C. Alterations in redox homeostasis in the elite endurance athlete. Sports Med. 2015;45:379-409 pubmed publisher
    ..Aerobic and anaerobic exercise results in alterations in redox homeostasis (ARH) in untrained, trained and well trained athletes...
  56. Pedroso J, Silveira M, Lima L, Furigo I, Zampieri T, Ramos Lobo A, et al. Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice. Endocrinology. 2016;157:3901-3914 pubmed
    ..deletion did not prevent fasting- or refeeding-induced c-Fos expression in the arcuate nucleus of the hypothalamus (ARH) nor fasting-induced increased excitability of ARH LepR-expressing cells...
  57. Alenazi F, Ibrahim B, Al Hamami H, Shakiya M, Briski K. Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat. Neuroscience. 2016;314:35-46 pubmed publisher
    ..Cc decreased PVH corticotropin-releasing hormone and arcuate (ARH) proopiomelanocortin (POMC) and neuropeptide Y in O, but suppressed only POMC in E...
  58. Fu C, Chan S, Wang S, Hsieh C, Liao C, Huang J, et al. The effect of angioembolization for life-threatening retroperitoneal hemorrhage in patients with pelvic fracture. Am J Emerg Med. 2019;37:603-607 pubmed publisher
    Conventionally, pelvic fracture-related acute retroperitoneal hemorrhage (ARH) is life threatening and difficult to control...
  59. Yang L, Yang P, Li D, Cai J, Shen Y, Dong W, et al. [Comparison of safety and efficacy of laparoscopic versus abdominal radical hysterectomy in the treatment of patients with stage I a2-II b cervical cancer]. Zhonghua Fu Chan Ke Za Zhi. 2015;50:915-22 pubmed
    To compare the safety and efficacy after laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) in the treatment of patients with stage I a2-II b cervical cancer...
  60. Djaout A, Chiappini B, Gaouar S, Afri Bouzebda F, Conte M, Chekkal F, et al. Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria. J Genet. 2018;97:453-461 pubmed
    ..Sequencing of the entire coding sequence of PRNP showed four main alleles (ARQ, ARR, AHQ and ARH) based on codons 136, 154 and 171 with different frequencies among the investigated breeds...
  61. Chong A, Vogt M, Hill A, Brüning J, Zeltser L. Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness. Mol Metab. 2015;4:83-92 pubmed publisher
    ..PVH) and in neurons expressing Agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus (ARH), respectively...
  62. D Erasmo L, Cefalù A, Noto D, Giammanco A, Averna M, Pintus P, et al. Efficacy of Lomitapide in the Treatment of Familial Homozygous Hypercholesterolemia: Results of a Real-World Clinical Experience in Italy. Adv Ther. 2017;34:1200-1210 pubmed publisher
    ..In this real-world experience, lomitapide was confirmed to be a very powerful cholesterol-lowering agent in HoFH showing a good safety profile. ..
  63. Paththinige C, Sirisena N, Dissanayake V. Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review. Lipids Health Dis. 2017;16:103 pubmed publisher
  64. Stitziel N, Fouchier S, Sjouke B, Peloso G, Moscoso A, Auer P, et al. Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2013;33:2909-14 pubmed publisher
  65. Radovica Spalvina I, Latkovskis G, Silamikelis I, Fridmanis D, Elbere I, Ventins K, et al. Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population. BMC Med Genet. 2015;16:86 pubmed publisher
    ..6 %). Three possible pathogenic variants were also found in four patients. NGS-based methods can be used to detect FH in high-risk individuals when they do not meet the defined clinical criteria. ..
  66. Wilson J, Enriori P. A talk between fat tissue, gut, pancreas and brain to control body weight. Mol Cell Endocrinol. 2015;418 Pt 2:108-19 pubmed publisher
    ..neuronal network consists of small populations of nuclei with distinct functions such as the arcuate nucleus (ARH), the paraventricular nuclei of the hypothalamus (PVH), the dorsomedial (DMH), the ventromedial (VMH) and the ..
  67. Marín Luna M, Alkorta I, Elguero J, Mó O, Yáñez M. Simultaneous aromatic-beryllium bonds and aromatic-anion interactions: naphthalene and pyrene as models of fullerenes, carbon single-walled nanotubes, and graphene. Chemphyschem. 2015;16:2680-6 pubmed publisher
    The possibility of forming stable BeR2 :ArH:Y(-) (R=H, F, Cl; ArH=naphthalene, pyrene; Y=Cl, Br) ternary complexes in which the beryllium compounds and anions are located on the opposite sides of an extended aromatic system is explored ..
  68. Kokkinos P, Mandilara G, Nikolaidou A, Velegraki A, Theodoratos P, Kampa D, et al. Performance of three small-scale wastewater treatment plants. A challenge for possible re use. Environ Sci Pollut Res Int. 2015;22:17744-52 pubmed publisher
    ..Salmonella spp. was detected in outlet sewage samples from Patra (PAT), Arachova (ARH), and Livadeia (LEV), at 23% (3/13), 33% (4/12), and 38% (5/13), respectively. Molds were detected at 92...
  69. Laterza R, Salvatore S, Ghezzi F, Serati M, Umek W, Koelbl H. Urinary and anal dysfunction after laparoscopic versus laparotomic radical hysterectomy. Eur J Obstet Gynecol Reprod Biol. 2015;194:11-6 pubmed publisher
    The aim of this study was to compare urinary and anal dysfunction after laparoscopic (LRH) and abdominal (ARH) radical hysterectomy for cervical cancer...
  70. Bailey J, Mendis K, Dutton T, Stevens W, McCrossin T. A decade of Rural Clinical School research: a PubMed review. Rural Remote Health. 2015;15:3353 pubmed
    ..Two authors independently checked all retrieved RCTS publications for validity. Australian rural health (ARH) publications from RCTS were selectively enumerated and their proportion among all Australian rural health ..
  71. Sun X, Fukami T, Li T, Desai M, Ross M. Preferential development of neuropeptide Y/GABA circuit in hypothalamic arcuate nucleus in postnatal rats. Brain Res. 2016;1635:27-40 pubmed publisher
    ..We investigated synaptogenesis and neurotransmission of neurons in arcuate nucleus of the hypothalamus (ARH) during the postnatal period using immunohistochemical and electrophysiological methods...
  72. Qiu J, Nestor C, Zhang C, Padilla S, Palmiter R, Kelly M, et al. High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons. elife. 2016;5: pubmed publisher
    ..Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1(ARH)) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide an episodic, excitatory drive to ..
  73. Steinberg A, Vince B, Choi Y, Martin R, McWherter C, Boudes P. The Pharmacodynamics, Pharmacokinetics, and Safety of Arhalofenate in Combination with Febuxostat When Treating Hyperuricemia Associated with Gout. J Rheumatol. 2017;44:374-379 pubmed publisher
    Arhalofenate (ARH), in development for gout, has uricosuric and anti-flare activities. ARH plus febuxostat (FBX) were evaluated in subjects with gout for serum uric acid (SUA) lowering, drug interaction, and safety...
  74. Chachlaki K, Malone S, Qualls Creekmore E, Hrabovszky E, Munzberg H, Giacobini P, et al. Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus. J Comp Neurol. 2017;525:3177-3189 pubmed publisher
    ..Intriguingly, nNOS was seen only after the second week of life in the arcuate nucleus of the hypothalamus (ARH)...
  75. Cai J, Yang L, Dong W, Wang H, Xiong Z, Wang Z. Retrospective comparison of laparoscopic versus open radical hysterectomy after neoadjuvant chemotherapy for locally advanced cervical cancer. Int J Gynaecol Obstet. 2016;132:29-33 pubmed publisher
    To compare outcomes after laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for locally advanced cervical cancer (LACC)after neoadjuvant chemotherapy (NACT)...
  76. Li X, Li J, Wen H, Ju X, Chen X, Xia L, et al. The Survival Rate and Surgical Morbidity of Abdominal Radical Trachelectomy Versus Abdominal Radical Hysterectomy for Stage IB1 Cervical Cancer. Ann Surg Oncol. 2016;23:2953-8 pubmed publisher
    ..the survival rates and morbidities of abdominal radical trachelectomy (ART) to abdominal radical hysterectomy (ARH) for stage IB1 cervical cancer and to evaluate the safety of ART for tumors measuring 2-4 cm...
  77. Thedrez A, Sjouke B, Passard M, Prampart Fauvet S, Guédon A, Croyal M, et al. Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report. Arterioscler Thromb Vasc Biol. 2016;36:1647-50 pubmed publisher particular alirocumab, be of therapeutic value for patients with autosomal recessive hypercholesterolemia (ARH)? Primary lymphocytes were obtained from 28 genetically characterized ARH patients and 11 controls...
  78. Zhang F, Liu Z, Zhang C, Jiang B. Short-term effects of floods on Japanese encephalitis in Nanchong, China, 2007-2012: A time-stratified case-crossover study. Sci Total Environ. 2016;563-564:1105-10 pubmed publisher
    ..CIs) at different lagged days, adjusting for daily average temperature (AT) and daily average relative humidity (ARH). A total of 370 JE cases were notified during the study period, with the median patient age being 4.2years...
  79. Sun S, Wang Y, Chen H, Fang L, Cui Y, Han X, et al. STIP Regulates ERK1/2 Signaling Pathway Involved in Interaction with PP1? in Lymphoblastic Leukemia. Curr Mol Med. 2016;16:767-775 pubmed
    ..The functional research of STIP was performed in ARH-77 by siRNA transfection, immunofluorescence, cell count, cell cycle analysis, qRT-PCR, sub-cellular fractionation ..
  80. Welge J, Saliba L, Strawn J, Eliassen J, Patino L, Adler C, et al. Neurofunctional Differences Among Youth With and at Varying Risk for Developing Mania. J Am Acad Child Adolesc Psychiatry. 2016;55:980-989 pubmed publisher depressed [ARD]; n = 32), healthy adolescents with a parent with bipolar disorder (at-risk healthy [ARH]; n = 32), and healthy adolescents with no personal or family history of psychiatric illness (healthy comparison [..
  81. Hovingh G, Smits L, Stefanutti C, Soran H, Kwok S, de Graaf J, et al. The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study. Am Heart J. 2015;169:736-742.e1 pubmed publisher
    ..This finding supports further clinical evaluation of apoA-I-containing particles in patients with HoFH. ..
  82. Wei H, Jiang S, Zhu Z, Yang T, Yang J, Yan X, et al. Improvements on high-precision measurement of bromine isotope ratios by multicollector inductively coupled plasma mass spectrometry. Talanta. 2015;143:302-306 pubmed publisher
    ..30; Zoom Quad: 0.00), the challenging problem of the isobaric interferences ((40)Ar(38)ArH(+) and (40)Ar(40)ArH(+)) in the measurement of bromine isotopes ((79)Br(+), (81)Br(+)) has been effectively solved...
  83. Usui S, Koketsu Y. Climatic factors associated with reproductive performance in English Berkshire pigs and crossbred pigs between Landrace and Large White raised in a subtropical climate region of Japan. Trop Anim Health Prod. 2015;47:1547-52 pubmed publisher
    ..Mean daily maximum temperatures (Tmax) and daily average relative humidity (ARH) for different time periods around servicing and farrowing of each female were coordinated with that female's ..
  84. Zernov N, Skoblov M, Marakhonov A, Shimomura Y, Vasilyeva T, Konovalov F, et al. Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles. J Invest Dermatol. 2016;136:1097-1105 pubmed publisher, we present a detailed comparative examination of individuals affected by autosomal-recessive hypotrichosis (ARH), which distinguishes two types of ARH...
  85. Wei W, Pham K, Gammons J, Sutherland D, Liu Y, Smith A, et al. Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice. Sci Rep. 2015;5:16810 pubmed publisher
    ..leads to persistent activation and leptin resistance in AgRP neurons in the arcuate nucleus of the hypothalamus (ARH)...
  86. Wang W, Shang C, Huang J, Chen S, Shen H, Yao S. [Long-term oncological outcomes after laparoscopic versus abdominal radical hysterectomy in stage I a2- II a2 cervical cancer: a matched cohort study]. Zhonghua Fu Chan Ke Za Zhi. 2015;50:894-901 pubmed
    ..of laparoscopic radical hysterectomy (LRH) plus lymph node dissection (LND) and abdominal radical hysterectomy (ARH) plus LND for patients with stage Ia2-IIa2 cervical cancer...
  87. D Erasmo L, Minicocci I, Nicolucci A, Pintus P, Roeters Van Lennep J, Masana L, et al. Autosomal Recessive Hypercholesterolemia: Long-Term Cardiovascular Outcomes. J Am Coll Cardiol. 2018;71:279-288 pubmed publisher
    Autosomal recessive hypercholesterolemia (ARH) is a rare lipid disorder characterized by premature atherosclerotic cardiovascular disease (ASCVD). There are sparse data for clinical management and cardiovascular outcomes in ARH...
  88. Lehtonen S, Shah M, Nielsen R, Iino N, Ryan J, Zhou H, et al. The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis. Mol Biol Cell. 2008;19:2949-61 pubmed publisher
    ..b>ARH (autosomal recessive hypercholesterolemia) is an endocytic clathrin-associated adaptor protein that sorts members ..
  89. Harada K, Miyamoto Y, Morisaki H, Ohta N, Yamanaka I, Kokubo Y, et al. A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia. J Atheroscler Thromb. 2010;17:131-40 pubmed
    The autosomal recessive hypercholesterolemia (ARH) gene is located on chromosome 1p35 and encodes a 308-amino acid protein containing a phosphotyrosine-binding domain...
  90. Vargas V, Gurung S, Grant B, Hyatt K, Singleton K, Myers S, et al. Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat. PLoS ONE. 2017;12:e0185272 pubmed publisher
    The effect of gestational hypoxia on the neonatal leptin surge, development of hypothalamic arcuate nuclei (ARH) projections and appetite that could contribute to the programming of offspring obesity is lacking...
  91. Maillard J, Park S, Croizier S, Vanacker C, Cook J, Prevot V, et al. Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits. Hum Mol Genet. 2016;25:3208-3215 pubmed publisher
    ..The arcuate nucleus of the hypothalamus (ARH) is critical for the regulation of homeostatic processes including feeding, and this nucleus develops during ..
  92. Al Kateb H, Bahring S, Hoffmann K, Strauch K, Busjahn A, Nurnberg G, et al. Mutation in the ARH gene and a chromosome 13q locus influence cholesterol levels in a new form of digenic-recessive familial hypercholesterolemia. Circ Res. 2002;90:951-8 pubmed
    ..1-p35 locus to LDL (P<0.002) in this normal population. Elucidation of ARH, the LDL receptor adaptor protein at chromosome 1p35, caused us to sequence that gene...