Gene Symbol: ARG1
Description: arginase 1
Alias: arginase-1, arginase, liver, liver-type arginase, type I arginase
Species: human
Products:     ARG1

Top Publications

  1. Miki K, Kumar A, Yang R, Killeen M, Delude R. Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation. Am J Physiol Gastrointest Liver Physiol. 2009;297:G840-8 pubmed publisher
    ..Thus reciprocal activation of arginase-1 and modulation of mucosal iNOS activity may be protective because it would be expected to decrease NO(*)-dependent intestinal barrier dysfunction on that basis. ..
  2. Dumont J, Zureik M, Cottel D, Montaye M, Ducimetiere P, Amouyel P, et al. Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness. J Med Genet. 2007;44:526-31 pubmed
    ..To evaluate the association between ARG1 polymorphisms and phenotypes related to atherosclerosis...
  3. Cao W, Sun B, Feitelson M, Wu T, Tur Kaspa R, Fan Q. Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis. Int J Cancer. 2009;124:2886-92 pubmed publisher
    ..The results showed that arginase 1 mRNA and protein were elevated about threefold in HCV positive compared with negative cells (p < 0.01)...
  4. Morris S. Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol. 2009;157:922-30 pubmed publisher
  5. Di Costanzo L, Ilies M, Thorn K, Christianson D. Inhibition of human arginase I by substrate and product analogues. Arch Biochem Biophys. 2010;496:101-8 pubmed publisher
    ..90 A resolution. This structure confirms the importance of hydrogen bond interactions with inhibitor alpha-carboxylate and alpha-amino groups as key specificity determinants of amino acid recognition in the arginase active site. ..
  6. Yan B, Gong C, Song J, Krausz T, Tretiakova M, Hyjek E, et al. Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol. 2010;34:1147-54 pubmed publisher
    ..Arg-1 represents a sensitive and specific marker of benign and malignant hepatocytes that may ultimately prove to be a useful diagnostic tool in routine surgical pathology practice. ..
  7. Bekpinar S, Gurdol F, Unlucerci Y, Develi S, Yilmaz A. Serum levels of arginase I are associated with left ventricular function after myocardial infarction. Clin Biochem. 2011;44:1090-1093 pubmed publisher
    ..019). Significantly low arginine/ADMA ratio was observed in MI patients. Induced arginase I after myocardial infarction may deplete the arginine pool. The changes related to arginine metabolism may have a role in ventricular dysfunction. ..
  8. Kim O, Lee S, Chung J, Do H, Moon J, Shin M. Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity. Nutrition. 2012;28:635-9 pubmed publisher
    ..The mRNA levels of genes (arginase I [ARG1], very low-density lipoprotein receptor [VLDLR], adiponectin receptor-1 [ADIPOR1], ADIPOR2, and nitric oxide ..
  9. McKnight R, Nassar A, Cohen C, Siddiqui M. Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology. Cancer Cytopathol. 2012;120:223-9 pubmed publisher
    ..Hence, use of arginase-1 with HepPar-1 and GPC-3 can aid in the diagnosis of HCC and separating from metastatic carcinoma. ..

More Information

Publications132 found, 100 shown here

  1. Meier L, Auger J, Engelson B, Cowan H, Breed E, Gonzalez Torres M, et al. CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis. Circulation. 2018;137:2478-2493 pubmed publisher
    ..g7 mice and are also present in human rheumatic heart disease. We define key inflammatory molecules that drive MVD in this model, including Syk, TNF, interleukin-6, very late antigen-4, and vascular cell adhesion molecule-1. ..
  2. Liao C, Lin Y, Kuo C. Effect of high-fat diet on hepatic proteomics of hamsters. J Agric Food Chem. 2015;63:1869-81 pubmed publisher
    ..CPS1), ornithine transcarbamoylase (OTC), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and arginase 1 (ARG 1). Post-translational modifications (PTM) of ANXA3, ANXA5, and XDH were also analyzed...
  3. Bhattacharya P, Dey R, Dagur P, Kruhlak M, Ismail N, Debrabant A, et al. Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice. Infect Immun. 2015;83:3800-15 pubmed publisher
    ..These data suggest that infection with live attenuated parasites promotes a state of classical activation (M1 dominant) in macrophages that leads to the generation of protective Th1 responses in BALB/c mice. ..
  4. Schlune A, Vom Dahl S, Häussinger D, Ensenauer R, Mayatepek E. Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. Amino Acids. 2015;47:1751-62 pubmed publisher
    Hyperargininemia is caused by deficiency of arginase 1, which catalyzes the hydrolysis of L-arginine to urea as the final enzyme in the urea cycle...
  5. Hsieh C, Lin C, He J, Chiang M, Wang Y, Tsai Y, et al. Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice. Stem Cell Res Ther. 2018;9:183 pubmed publisher
    ..b>Arginase 1 and inducible NO synthase expressions of MDSCs were evaluated using quantitative reverse-transcriptase PCR...
  6. Medina Colorado A, Osorio E, Saldarriaga O, Travi B, Kong F, Spratt H, et al. Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression. PLoS ONE. 2017;12:e0169496 pubmed publisher
    ..PD-L2 blockade was associated with a dramatic reduction in expression of host arginase 1, but no change in IFN? and inducible nitric oxide synthase...
  7. Diz Chaves Y, Toba L, Fandino J, González Matías L, Garcia Segura L, Mallo F. The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction. J Neuroinflammation. 2018;15:337 pubmed publisher
    ..interleukin-6 (IL-6), nuclear factor-κβ, major histocompatibility complex-II (MHCII), interleukin 10 (IL10), arginase 1 (Arg1), and transforming growth factor (TGFβ) were assessed in the hippocampus by quantitative real-time ..
  8. Dorhoi A, Kaufmann S. Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis. Semin Immunopathol. 2016;38:153-66 pubmed publisher
    ..Distinct lesions coexist such that inflammation in TB encompasses a spectrum of tissue changes. A better understanding of the multidimensionality of immunopathology in TB will inform novel therapies against this pulmonary disease. ..
  9. Cipriani G, Gibbons S, Miller K, Yang D, Terhaar M, Eisenman S, et al. Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice. Gastroenterology. 2018;154:2122-2136.e12 pubmed publisher
    ..synthase) and lower levels of messenger RNAs encoding markers of anti-inflammatory cells (heme oxygenase 1, arginase 1, and FIZZ1) than macrophages isolated from diabetic mice with normal gastric emptying...
  10. Lee J, Wei Z, Cao W, Won S, Gu X, Winter M, et al. Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice. Neurobiol Dis. 2016;96:248-260 pubmed publisher
  11. Yao L, Bhatta A, Xu Z, Chen J, Toque H, Chen Y, et al. Obesity-induced vascular inflammation involves elevated arginase activity. Am J Physiol Regul Integr Comp Physiol. 2017;313:R560-R571 pubmed publisher
    ..Our previous studies showed that arginase 1 (A1) in endothelial cells (ECs) is critically involved in obesity-induced vascular dysfunction...
  12. Harmon E, Fronhofer V, Keller R, Feustel P, Zhu X, Xu H, et al. Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques. J Am Heart Assoc. 2014;3:e001232 pubmed publisher
    ..Plaques from DKO animals expressed higher arginase 1 (Arg‐1) and lower inducible nitric oxide synthase (iNOS), indicating the presence of M2 macrophages...
  13. Li Y, Zhang C, Sheng Q, Bai H, Ding Y, Dou X. Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages. World J Gastroenterol. 2017;23:7978-7988 pubmed publisher
    ..11 ± 51.59 pg/mL vs 104.07 ± 42.80 pg/mL, P < 0.001). M2 polarization contributes to the therapeutic effects of MSCs in AHF by altering levels of anti-inflammatory and pro-inflammatory factors. ..
  14. Luong V, Chino T, Oyama N, Matsushita T, Sasaki Y, Ogura D, et al. Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis. Arthritis Res Ther. 2018;20:46 pubmed publisher
    ..HPH-15 treatment resulted in decreased messenger RNA (mRNA) expression of the M2 macrophage markers arginase 1 and Ym-1 in the skin, whereas it inversely augmented expression of Friend leukemia integration 1 and Krüppel-..
  15. Singh K, Coburn L, Barry D, Boucher J, Chaturvedi R, Wilson K. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1061-73 pubmed publisher
    ..Migration was impaired in CECs treated with L-Lys or from CAT2(-/-) mice. Wounding increased Arg1 expression, and inhibition of arginase with S-(2-boronoethyl)-L-cysteine (BEC) or Arg1 shRNA inhibited restitution ..
  16. Hammerich L, Warzecha K, Stefkova M, Bartneck M, Ohl K, Gassler N, et al. Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice. Hepatology. 2015;61:990-1002 pubmed publisher
    ..Cremtg MDSCs isolated from liver expressed reduced inducible nitric oxide synthase and arginase 1 and displayed a reduced T-cell suppressive activity...
  17. Dyck S, Kataria H, Alizadeh A, Santhosh K, Lang B, Silver J, et al. Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury. J Neuroinflammation. 2018;15:90 pubmed publisher
    ..More importantly, this work introduces the potential of ILP/ISP as a viable strategy for modulating the immune response following SCI and other neuroinflammatory conditions of the central nervous system. ..
  18. Wang P, Xu L, Qin J, Zhang L, Zhuang G. MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression. Biochem Biophys Res Commun. 2018;503:452-458 pubmed publisher
    ..Thus, miR-155-modulated FGF2 might be a potential therapeutic target to prevent EC progression. ..
  19. Roberts N, Alqazzaz A, Hwang J, Qi X, Keegan A, Kim A, et al. Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction. J Neurooncol. 2018;140:497-507 pubmed publisher
    ..In BMDMs exposed to GCM, OXA also reduced levels of phosphorylated STAT3 and decreased expression of Arginase 1, an enzyme known to contribute to pro-tumor functions in the tumor-immune environment...
  20. Chen Y, Xu X, Zhang Y, Liu K, Huang F, Liu B, et al. Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK. J Steroid Biochem Mol Biol. 2016;155:155-65 pubmed publisher
    ..and inducible nitric oxide synthase (iNOS), while reduced gene expressions for adiponectin, PPARγ, and arginase 1 (Arg-1) were reversed by diosgenin treatment...
  21. Shoulders H, Garner K, Singla D. Macrophage depletion by clodronate attenuates bone morphogenetic protein-7 induced M2 macrophage differentiation and improved systolic blood velocity in atherosclerosis. Transl Res. 2019;203:1-14 pubmed publisher
    ..05). Overall, this study suggests that clodronate treatment inhibits BMP-7 induced differentiation of monocytes into M2 macrophages and improved systolic blood velocity. ..
  22. Hansakon A, Mutthakalin P, Ngamskulrungroj P, Chayakulkeeree M, Angkasekwinai P. Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages. Virulence. 2019;10:26-36 pubmed publisher
    ..Abbreviation: Arg1: Arginase 1; BAL: Bronchoalveolar lavage; CCL17: Chemokine (C-C motif) ligand 17; CNS: Central nervous system; CSF: ..
  23. Zhu T, Miller A, Deliyanti D, Berka D, Agrotis A, Campbell D, et al. Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia. Clin Exp Pharmacol Physiol. 2015;42:537-48 pubmed publisher
    ..In conclusion, prorenin has distinct pro-angiogenic and pro-inflammatory effects on retinal cells that are independent of the AT1R, indicating the potential importance of prorenin in retinopathy. ..
  24. Sharma P, Sharma A, Vishwakarma A, Agnihotri P, Sharma S, Srivastava M. Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages. J Leukoc Biol. 2016;99:619-28 pubmed publisher
    ..Therapeutic interventions that can boost host immune response in the lungs might thus provide relief to patients with tropical pulmonary eosinophilia. ..
  25. Potoka K, Gladwin M. Vasculopathy and pulmonary hypertension in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2015;308:L314-24 pubmed publisher
    ..Cell free plasma hemoglobin, heme, and arginase 1 disrupt endothelial function, drive oxidative and inflammatory stress, and have recently been referred to as ..
  26. Su Z, Hu L, Cheng J, Klein J, Hassounah F, Cai H, et al. Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy. J Appl Physiol (1985). 2016;120:426-36 pubmed publisher
    ..Upregulation of IGF-1, downregulation of myostatin, and alteration of microRNAs contribute to the attenuation of muscle atrophy in denervated mice. ..
  27. Liu L, Yi H, He H, Pan H, Cai L, Ma Y. Tumor associated macrophage-targeted microRNA delivery with dual-responsive polypeptide nanovectors for anti-cancer therapy. Biomaterials. 2017;134:166-179 pubmed publisher
    ..through elevating M1 macrophage markers (IL-12, iNOS, MHC II) and suppressing M2 macrophage markers (Msr2 and Arg1) in TAMs...
  28. Sawa Wejksza K, Kandefer Szerszen M. Tumor-Associated Macrophages as Target for Antitumor Therapy. Arch Immunol Ther Exp (Warsz). 2018;66:97-111 pubmed publisher
    ..Furthermore, TAMs-derived cytokines and other proteins, such as CCL-17, CCL-22, TGF-β, IL-10, arginase 1, and galectin-3, make a significant contribution to immunosuppression...
  29. Pinheiro C, de Queiroz J, Guimarães Ferreira L, Vitzel K, Nachbar R, de Sousa L, et al. Local injections of adipose-derived mesenchymal stem cells modulate inflammation and increase angiogenesis ameliorating the dystrophic phenotype in dystrophin-deficient skeletal muscle. Stem Cell Rev. 2012;8:363-74 pubmed publisher
    ..These results suggest that ADMSC transplantation modulates inflammation and improves muscle tissue regeneration, ameliorating the dystrophic phenotype in dystrophin-deficient mice. ..
  30. Babu M, Durga Devi T, Mäkinen P, Kaikkonen M, Lesch H, Junttila S, et al. Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study. Circ Res. 2015;117:289-99 pubmed publisher
    ..hypomethylated, whereas alternatively activated M2-MÏ• gene promoters, including Nrp1, Cxcr4, Plxnd1, Arg1, Cdk18, and Fes, were significantly hypermethylated in MÏ•s isolated from hyperlipidemia and T2DM ischemic ..
  31. Theotokis P, Touloumi O, Lagoudaki R, Nousiopoulou E, Kesidou E, Siafis S, et al. Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination. J Neuroinflammation. 2016;13:265 pubmed
    ..Its expression by inflammatory macrophages/monocytes could signify a possible role of these cells on axonal guidance and clearance of the lesioned area during inflammatory demyelination. ..
  32. Li Z, Liu F, Ma H, White P, Yumul R, Jiang Y, et al. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. Brain Res. 2017;1665:65-73 pubmed publisher
    ..factor (BDNF), synaptophysin, Ionized calcium-binding adapter molecule 1 (Iba-1), microglial M2 phenotype marker Arg1, and CD200 were also examined in the hippocampus...
  33. Duan J, Zhou Y, Zhou A, Guan X, Liu T, Yang H, et al. Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro. Mol Immunol. 2017;91:105-113 pubmed publisher
    ..expression of tumor necrosis factor-? (a marker of pro-inflammatory phenotype of macrophages, M1 macrophages) or Arginase 1 (Arg1, a marker of M2 macrophages) in non-differentiated macrophages, CGRP significantly reduced the NLRP3 and ..
  34. Binnemars Postma K, Bansal R, Storm G, Prakash J. Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer. FASEB J. 2017;: pubmed publisher
    ..Binnemars-Postma, K., Bansal, R., Storm, G., Prakash, J. Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer...
  35. Namdar A, Mirzaei R, Memarnejadian A, Boghosian R, Samadi M, Mirzaei H, et al. Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model. Cancer Immunol Immunother. 2018;67:367-379 pubmed publisher
    ..In conclusion, our results revealed that Foxp3 vaccine promotes an immune response against tumor by targeting both Treg and MDSC, which could be exploited as a potential immunotherapy approach. ..
  36. Carvalho D, Brand G, Brum J, Takata R, Speck Martins C, Pratesi R. Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes. Gene. 2012;509:124-30 pubmed publisher
    ..It is caused by the deficient activity of the enzyme arginase I, encoded by the gene ARG1. We screened for ARG1 mutations and measured erythrocyte enzyme activity in a series of 16 Brazilian HA patients...
  37. Antonenko Y, Gluhov G, Firsov A, Pogozheva I, Kovalchuk S, Pechnikova E, et al. Gramicidin A disassembles large conductive clusters of its lysine-substituted derivatives in lipid membranes. Phys Chem Chem Phys. 2015;17:17461-70 pubmed publisher
    ..Here, the leakage induction was also observed for [Arg1]gA and [Arg3]gA, while [His1]gA and [His3]gA were inactive at neutral pH...
  38. Su M, Cao J, Huang J, Liu S, Im D, Yoo J, et al. The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-? Agonist. Mar Drugs. 2017;15: pubmed publisher
    ..These findings suggest that PD1 be viewed as a lead compound for the development of novel anti-inflammatory therapeutics. ..
  39. Yang Z, Xu J, Zhu R, Liu L. Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38. Med Sci Monit. 2017;23:405-411 pubmed
    ..of microglial M1 phenotypic markers CD86 and CD32, and increased the expression levels of M2 phenotypic markers Arg1 and CD206. Furthermore, miR-128 overexpression obviously decreased the concentration of TNF-?, IL-1?, and IL-6...
  40. Banerjee B, Koner D, Lal P, Saha N. Unique mitochondrial localization of arginase 1 and 2 in hepatocytes of air-breathing walking catfish, Clarias batrachus and their differential expression patterns under hyper-ammonia stress. Gene. 2017;622:13-22 pubmed publisher
    ..isoforms of ARG have been reported in vertebrates, out of which the two predominant isoforms are the cytosolic ARG1 and the mitochondrial ARG2...
  41. Huang Z, Gao C, Chi X, Hu Y, Zheng L, Zeng T, et al. IL-37 Expression is Upregulated in Patients with Tuberculosis and Induces Macrophages Towards an M2-like Phenotype. Scand J Immunol. 2015;82:370-9 pubmed publisher
    ..Furthermore, this phenotypic shift was accompanied by upregulated mRNA levels of arginase 1, TGF-β and IL-10, which are characteristic hallmarks of M2 macrophages...
  42. Mairhofer D, Ortner D, Tripp C, Schaffenrath S, Fleming V, Heger L, et al. Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model. J Invest Dermatol. 2015;135:2785-2793 pubmed publisher
    ..In this work, we describe the immune status of a spontaneous melanoma mouse model that provides an interesting tool to develop future immunotherapeutical strategies. ..
  43. Trad M, Gautheron A, Fraszczak J, Alizadeh D, Larmonier C, LaCasse C, et al. T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1. Biomed Res Int. 2015;2015:891236 pubmed publisher
  44. Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman Yassky E, et al. Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. J Immunol. 2017;199:1827-1834 pubmed publisher
    ..from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible NO synthase (iNOS) dynamic in monocytes/macrophages (mono/M?), which renders those cells ineffectual ..
  45. Ochoa J, Bernard A, O Brien W, Griffen M, Maley M, Rockich A, et al. Arginase I expression and activity in human mononuclear cells after injury. Ann Surg. 2001;233:393-9 pubmed
    ..Arginase, rather than nitric oxide synthase, appears to be the dominant route for arginine metabolism in immune cells after trauma. ..
  46. Garcia D, Uribe E, Lobos M, Orellana M, Carvajal N. Studies on the functional significance of a C-terminal S-shaped motif in human arginase type I: essentiality for cooperative effects. Arch Biochem Biophys. 2009;481:16-20 pubmed publisher
    ..The S-shaped motif is suggested as essential for the cooperative response of the enzyme to l-arginine at pH 7.5. Gdn(+) is suggested to mimic the guanidine group of Arg-308 at the monomer-monomer interface. ..
  47. Jung K, Sabri S, Hanson J, Xu Y, Wang Y, Lai R, et al. Elevated ARG1 expression in primary monocytes-derived macrophages as a predictor of radiation-induced acute skin toxicities in early breast cancer patients. Cancer Biol Ther. 2015;16:1281-8 pubmed publisher
    ..them with M1 or M2-inducing cytokines before quantitative analysis of their "M1/M2" activation markers, iNOS, Arg1, and TGFß1...
  48. Sakamoto S, Yoshitomi M, Yutani S, Terazaki Y, Yoshiyama K, Ioji T, et al. Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination. Hum Vaccin Immunother. 2015;11:2784-9 pubmed publisher
    ..factors derived from granulocytes, such as matrix metalloproteinase 9 (MMP-9), myeloperoxidase (MPO), and arginase 1 (ARG1), and inhibitory cytokine TGFβ in pre-vaccination plasma were useful for predicting prognosis after PPV ..
  49. Xiang J, Cheng S, Feng T, Wu Y, Xie W, Zhang M, et al. Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. Int Immunopharmacol. 2016;36:158-164 pubmed publisher
    ..In conclusion, our study demonstrated for the first time that NTS has a significant protective effect on BLM-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. ..
  50. Shapiro M, Senapathy P. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 1987;15:7155-74 pubmed
    ..This method was used to find a majority of the exons in selected known genes, and also predicted potential new exons which may be used in alternative splicing situations. ..
  51. Hertecant J, Al Gazali L, Karuvantevida N, Ali B. A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family. Saudi Med J. 2009;30:1601-3 pubmed
    ..At least 19 distinct mutations in the ARG1 gene have been identified indicating the molecular heterogeneity of this condition...
  52. Shi X, Li Y, Fan J, Zeng X, Xian Z, Wang Z, et al. Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells. Cell Death Dis. 2014;5:e1563 pubmed publisher
    ..Cell Death and Disease (2014) 5, e1563; doi:10.1038/cddis.2014.503; published online 11 December 2014. ..
  53. Yuan C, Zheng Y, Zhang B, Shao L, Liu Y, Tian T, et al. Thymosin α1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1. Biochem Biophys Res Commun. 2015;464:249-55 pubmed publisher
    ..Furthermore, immunosuppressive myeloid-derived suppressor cells (MDSCs) showed heightened Arginase 1 production in response to Tα1 treatment, which led to stronger suppression of anti-tumor immunity...
  54. Ampem G, Azegrouz H, Bacsadi Ã, Balogh L, Schmidt S, Thuróczy J, et al. Adipose tissue macrophages in non-rodent mammals: a comparative study. Cell Tissue Res. 2016;363:461-78 pubmed publisher
    ..Thus, we show, for the first time, that the presence of ATMs is a general trait of mammals. The interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals. ..
  55. Liu Q, Tian Y, Zhao X, Jing H, Xie Q, Li P, et al. NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization. Mol Cells. 2015;38:886-94 pubmed publisher
    ..Our results indicate that NMAAP1 is an essential molecule that modulates macrophages phenotype and plays an important role in macrophage tumoricidal functions. ..
  56. Iyer R, Jenkinson C, Vockley J, Kern R, Grody W, Cederbaum S. The human arginases and arginase deficiency. J Inherit Metab Dis. 1998;21 Suppl 1:86-100 pubmed
    ..The evidence for the role of AII in nitric oxide and polyamine metabolism is presented and this appears consonant with the data on the tissue distribution...
  57. Chen B, Calvert A, Cui H, Nelin L. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1151-9 pubmed publisher
    ..These data support our hypothesis that hypoxia increases proliferation of hPASMC through the induction of arginase II. ..
  58. Higuchi H, Shoji T, Murase Y, Iijima S, Nishijima K. Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Biosci Biotechnol Biochem. 2016;80:501-9 pubmed publisher
    ..The induction of arginase-1 (Arg1) by IL-4 was stronger in Siglec-9-expressing cells than in mock cells...
  59. Hayakawa K, Wang X, Lo E. CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling. J Neurochem. 2016;136:900-6 pubmed publisher
    ..Here, we propose that CD200 treatment may help shift pro-inflammatory macrophages to an arginase 1 (Arg1)-, transglutaminase 2 (TGM2)-, and transforming growth factor beta 1 (TGF-β)-positive phenotype...
  60. Kang J, Lee S. Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis. Biochim Biophys Acta. 2016;1861:1025-1035 pubmed publisher
    ..from mice exposed to IR, the levels of M1 marker genes (Nos2a and Cd40) increased, while those of M2 marker genes (Arg1, Cd206, and Mst1r) decreased, demonstrating a proinflammatory shift. RvD1 markedly attenuated these changes...
  61. Akhtar F, Rouse C, Catano G, Montalvo M, Ullevig S, Asmis R, et al. Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress. J Neuroinflammation. 2017;14:195 pubmed publisher
    ..M1-like (IL-1?, IFN ?, IL-6, CCL3, CCL4, CCL-7, CCL9,) or M2-like (TGF-?, IL-4, IL-10, CCL2, CCL22, CXCL10, Arg1, Chi1, CCR2 and CXCR2) and measured in the brain by qRT-PCR and ELISA...
  62. Chen S, Li R, Cheng C, Xu J, Jin C, Gao F, et al. Pseudomonas aeruginosa infection alters the macrophage phenotype switching process during wound healing in diabetic mice. Cell Biol Int. 2018;42:877-889 pubmed publisher
    ..These data demonstrated that P. aeruginosa in diabetic wounds activates a mixed M1/M2 macrophage phenotype with an excessive activation of M1 phenotype or relatively inadequate activation of M2 phenotype. ..
  63. Yin X, Pang C, Bai L, Zhang Y, Geng L. [Adipose-derived stem cells promote the polarization from M1 macrophages to M2 macrophages]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:332-8 pubmed
    ..necrosis factor α (TNF-α), inducible nitric oxide synthase (iNOS), CC chemokine ligand 2 (CCL2), CD86, arginase 1 (Arg1), mannose receptors/CD206 (MR/CD206), IL-10, found in inflammatory zone 1 (FIZZ1), chitinase 3-like 3 (Ym-..
  64. Sun Z, Zhou D, Xie X, Wang S, Wang Z, Zhao W, et al. Cross-talk between macrophages and atrial myocytes in atrial fibrillation. Basic Res Cardiol. 2016;111:63 pubmed AF patients and found that the increased macrophages were mainly pro-inflammatory macrophages (iNOS+, Arg1-). Tachypacing of HL-1 atrial myocytes also led to pro-inflammatory macrophage polarization...
  65. Samsoondar J, Burke A, Sutherland B, Telford D, Sawyez C, Edwards J, et al. Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr-/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid. Arterioscler Thromb Vasc Biol. 2017;37:647-656 pubmed publisher
    ..ester accumulation, attenuated the expression of proinflammatory M1 genes and attenuated the iNos/Arg1 ratio...
  66. Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
    ..g. OTC, ARG1, CPS1), and amino acid biosynthesis (e.g. GMT, AKR1C6)...
  67. Duan Q, Gaume B, Hawkins G, Himes B, Bleecker E, Klanderman B, et al. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med. 2011;183:449-54 pubmed publisher
    ..We previously identified single nucleotide polymorphisms in the arginase 1 (ARG1) gene, which are associated with ??-agonist bronchodilator response (BDR)...
  68. Lively S, Hutchings S, Schlichter L. Molecular and Cellular Responses to Interleukin-4 Treatment in a Rat Model of Transient Ischemia. J Neuropathol Exp Neurol. 2016;: pubmed
    ..At 1?day, IL-4 treatment increased striatal expression of several anti-inflammatory markers (ARG1, CCL22, CD163, PPAR?), increased phagocytic (Iba1-positive, CD68-positive) microglia/macrophages, and increased ..
  69. Drabczyk Pluta M, Werner T, Hoffmann D, Leng Q, Chen L, Dittmer U, et al. Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection. Retrovirology. 2017;14:42 pubmed publisher
    ..gMDSCs expressed arginase 1, high levels of the inhibitory ligand PD-L1 and the ATP dephosphorylating enzyme CD39 on the cell surface upon ..
  70. Chen M, Zhao J, Ali I, Marry S, Augustine J, Bhuckory M, et al. Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis. Am J Pathol. 2018;188:1007-1020 pubmed publisher
  71. Kusano K, Gainer H, Battey J, Fathi Z, Wada E. Receptor-activated currents in mouse fibroblasts expressing transfected bombesin receptor subtype cDNAs. Am J Physiol. 1993;265:C869-76 pubmed
    ..N-acetyl-GRP-(20-26) amide, [Leu13-psi(CH2NH)-Leu14]Bn, and [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P also blocked GRP Rt responses but at higher concentrations (10(-5) M)...
  72. Holowatz L, Kenney W. Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans. J Physiol. 2007;581:863-72 pubmed
    ..Vasodilatation is attenuated with HTN due to decreased NO-dependent vasodilatation and can be augmented with arginase inhibition but not L-arg supplementation, suggesting that arginase is up-regulated with HTN. ..
  73. Gannon P, Godin Ethier J, Hassler M, Delvoye N, Aversa M, Poisson A, et al. Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer. PLoS ONE. 2010;5:e12107 pubmed publisher
    ..In this report, we demonstrate that both ARG1 and ARG2 are expressed by hormone-sensitive (HS) and hormone-refractory (HR) PCa cell lines, with the LNCaP cells ..
  74. Vasquez Dunddel D, Pan F, Zeng Q, Gorbounov M, Albesiano E, Fu J, et al. STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest. 2013;123:1580-9 pubmed
    ..Taken together, these results demonstrate that the suppressive function of arginase-I in both infiltrating and circulating MDSC is a downstream target of activated STAT3...
  75. França Costa J, Van Weyenbergh J, Boaventura V, Luz N, Malta Santos H, Oliveira M, et al. Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis. J Infect Dis. 2015;211:426-35 pubmed publisher
    ..Our data implicate arginase I, ODC, PGE2, and TGF-? in the failure to mount an efficient immune response and suggest perspectives in the development of new strategies for therapeutic intervention for patients with DCL. ..
  76. Getaneh A, Tamrat A, Tadesse K. Arginase activity in peripheral blood of patients with intestinal schistosomiasis, Wonji, Central Ethiopia. Parasite Immunol. 2015;37:380-3 pubmed publisher
    ..61 + 2.19, controls: 0.31 + 0.73 mU/mL plasma, P < 0.0001) arginase activity was observed during human S. mansoni infection. Arginase activity increases in peripheral blood of patients with intestinal schistosomiasis. ..
  77. Torres Castro I, Arroyo Camarena Ú, Martínez Reyes C, Gómez Arauz A, Dueñas Andrade Y, Hernández Ruiz J, et al. Human monocytes and macrophages undergo M1-type inflammatory polarization in response to high levels of glucose. Immunol Lett. 2016;176:81-9 pubmed publisher
    ..These results demonstrate that excess glucose has direct effects on macrophage activation though the molecular mechanisms mediating such a response remain to be elucidated. ..
  78. Orr M, Simkin J, Bailey W, Kadambi N, McVicar A, Veldhorst A, et al. Compression Decreases Anatomical and Functional Recovery and Alters Inflammation after Contusive Spinal Cord Injury. J Neurotrauma. 2017;34:2342-2352 pubmed publisher
    ..CD86 and macrophage receptor with collagenous structure [MARCO]) and reparative macrophages (arginase [Arg1] and CD206)...
  79. Lin T, Pajarinen J, Nabeshima A, Lu L, Nathan K, Yao Z, et al. Establishment of NF-?B sensing and interleukin-4 secreting mesenchymal stromal cells as an "on-demand" drug delivery system to modulate inflammation. Cytotherapy. 2017;19:1025-1034 pubmed publisher
    ..nitric oxide synthase [iNOS] and tumor necrosis factor alpha [TNF?]) expression and enhanced M2 marker (Arginase 1, CD206 and IL1 receptor antagonist [IL1Ra]) expression in primary murine macrophages...
  80. Tariq M, Zhang J, Liang G, He Q, Ding L, Yang B. Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway. Acta Pharmacol Sin. 2017;38:1501-1511 pubmed publisher
    ..of the M2 surface markers CD206 and CD163, down-regulation of specific M2-marker genes (Mrc1, Ym1, Fizz1, Arg1, IL-10 and CCL2) as well as inhibition of M2-like macrophage-mediated invasion and migration of LLC cells...
  81. Li B, Huo Y, Lin Z, Wang T. [DNA hydroxymethylase 10-11 translocation 2 (TET2) inhibits mouse macrophage activation and polarization]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1165-1170 pubmed
    ..TNF-α, inducible nitric oxide synthase (iNOS) and IL-12, and M2 polarizing markers mannose receptor (MR), arginase 1 (Arg-1) and chitinase 3-like molecule 1 (Ym1) were tested after M1 or M2 induction by LPS/IFN-γ or IL-4...
  82. Parveen S, Chowdhury A, Jawed J, Majumdar S, Saha B, Majumdar S. Immunomodulation of dual specificity phosphatase 4 during visceral leishmaniasis. Microbes Infect. 2018;20:111-121 pubmed publisher
    ..donovani infection. On the other hand, GA failed to increase Th1 cytokine production and decrease Th2 response during DUSP4 knock-down condition suggesting the key role of DUSP4 while providing protection during L. donovani infection. ..
  83. Zhang B, Ma Y, Xiang C. SIRT2 decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by modulating macrophage polarization. Biomed Pharmacother. 2018;97:1238-1242 pubmed publisher
    ..These findings suggest that SIRT2 inhibited atherosclerotic plaque progression and enhanced plaque stability in LDLr-/- mice by inhibiting macrophage polarization towards the M1 phenotype. ..
  84. Uchino T, Snyderman S, Lambert M, Qureshi I, Shapira S, Sansaricq C, et al. Molecular basis of phenotypic variation in patients with argininemia. Hum Genet. 1995;96:255-60 pubmed
    ..Plasma arginine levels during treatment correlated with types of molecular defects in the arginase genes. ..
  85. Waddington S. Arginase in glomerulonephritis. Kidney Int. 2002;61:876-81 pubmed
    ..In particular, it consolidates the current understanding of arginase and associated metabolic pathways, and highlights some of the issues that are often overlooked in such studies. ..
  86. Morris C, Kato G, Poljakovic M, Wang X, Blackwelder W, Sachdev V, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA. 2005;294:81-90 pubmed
    ..The ratios of arginine to ornithine and arginine to ornithine plus citrulline are independently associated with pulmonary hypertension and increased mortality in patients with sickle cell disease. ..
  87. Mora A, Torres Gonzalez E, Rojas M, Corredor C, Ritzenthaler J, Xu J, et al. Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis. Am J Respir Cell Mol Biol. 2006;35:466-73 pubmed
    ..These results suggest that virus-induced upregulation of arginase I could be a mechanism driving lung fibrogenesis. ..
  88. Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z. Arginase-flotillin interaction brings arginase to red blood cell membrane. FEBS Lett. 2006;580:6561-4 pubmed
    ..The arginase activity in diabetic patients was significantly higher than that of the controls (752.4+/-38.5 U/mg protein vs 486.7+/-28.7 U/mg protein). ..
  89. Muller I, Hailu A, Choi B, Abebe T, Fuentes J, Munder M, et al. Age-related alteration of arginase activity impacts on severity of leishmaniasis. PLoS Negl Trop Dis. 2008;2:e235 pubmed publisher
    ..mice do not have an impaired capacity to kill parasites; however, they express significantly higher levels of arginase 1 than aged mice and promote parasite growth more efficiently...
  90. North M, Khanna N, Marsden P, Grasemann H, Scott J. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol. 2009;296:L911-20 pubmed publisher
    ..To investigate the role of arginase isozymes (ARG1 and ARG2) in AHR, we determined the protein expression of ARG1, ARG2, the NOS isozymes, and other proteins involved ..
  91. Krings G, Ramachandran R, Jain D, Wu T, Yeh M, Torbenson M, et al. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Mod Pathol. 2013;26:782-91 pubmed publisher
    ..Glypican 3 and arginase are the most reliable markers for identifying hepatocellular differentiation in this setting. ..
  92. Dimitriades V, Rodriguez P, Zabaleta J, Ochoa A. Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis. Ann Allergy Asthma Immunol. 2014;113:271-5 pubmed publisher