ARFGAP2

Summary

Gene Symbol: ARFGAP2
Description: ADP ribosylation factor GTPase activating protein 2
Alias: IRZ, NBLA10535, ZFP289, ZNF289, ADP-ribosylation factor GTPase-activating protein 2, GTPase-activating protein ZNF289, zinc finger protein 289, ID1 regulated
Species: human
Products:     ARFGAP2

Top Publications

  1. Watson P, Frigerio G, Collins B, Duden R, Owen D. Gamma-COP appendage domain - structure and function. Traffic. 2004;5:79-88 pubmed
    ..in yeast this site binds to the ARFGAP Glo3p, and in mammalian gamma-COP this site binds to a Glo3p orthologue, ARFGAP2. On the basis of mutations in the yeast homologue of gamma-COP, Sec21p, a second binding site is proposed to ..
  2. Frigerio G, Grimsey N, Dale M, Majoul I, Duden R. Two human ARFGAPs associated with COP-I-coated vesicles. Traffic. 2007;8:1644-55 pubmed
    ..Here, based on a conserved signature motif close to the carboxy terminus, we identify ARFGAP2 and ARFGAP3 as the human orthologues of yeast Glo3p...
  3. Singh J, Itahana Y, Parrinello S, Murata K, Desprez P. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. J Biol Chem. 2001;276:11852-8 pubmed
    ..Now we report the cloning of a novel zinc finger protein, Zfp289, using degenerate primers to specifically amplify cDNAs from Id-1-transfected SCp2 cells...
  4. Stuckert A, Moore E, Coyle K, Davison I, Macmanes M, ROBERTS R, et al. Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus. BMC Evol Biol. 2019;19:85 pubmed publisher
    ..g., arfgap1, arfgap2, airc, and gart)...
  5. Meunier G. Economic assessment of nutritional recommendations: A comment. J Health Econ. 2019;65:43-47 pubmed publisher
    This is a comment on the paper by Irz et al. (2015) in this journal, on nutritional recommendations. Irz et al...
  6. Dong J, Dong Y, Wen C, Gao S, Ren L, Bao Q. A 2D tank test on remediation of nitrobenzene-contaminated aquifer using in-situ reactive zone with emulsified nanoscale zero-valent iron. Chemosphere. 2018;206:766-776 pubmed publisher
    ..9 L of EZVI solution was injected into aquifer to establish in-situ reactive zone (IRZ) before 40?d of NB contamination...
  7. Lo I, Gupta V, Midde K, Taupin V, López Sánchez I, Kufareva I, et al. Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling. Dev Cell. 2015;33:189-203 pubmed publisher
    ..Several interactions with other major components of Golgi trafficking-e.g., active Arf1, its regulator, ArfGAP2/3, and the adaptor protein β-COP-enable GIV to coordinately regulate Arf1 signaling...
  8. Xin J, Tang F, Yan J, La C, Zheng X, Liu W. Investigating the efficiency of microscale zero valent iron-based in situ reactive zone (mZVI-IRZ) for TCE removal in fresh and saline groundwater. Sci Total Environ. 2018;626:638-649 pubmed publisher
    ..electron efficiency (EE), and permeability loss of a microscale zero valent iron-based in situ reactive zone (mZVI-IRZ) under different field conditions...
  9. Komendová I, Spitalnikova S. Intellectual performance of children of mothers with an untreated thyroid disorder in the first trimester of pregnancy. Endokrynol Pol. 2018;69:241-245 pubmed publisher
    ..67), verbal IQ (p=0.81), performance IQ (p=0.41), or the individual scores (ISP: p=0.85; IPU: p=0.54, IKO: p=0.57; IRZ: p=0...

More Information

Publications20

  1. Estrada A, Muruganandam G, Prescianotto Baschong C, Spang A. The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes. Biol Open. 2015;4:792-802 pubmed publisher
    ..Here we show that a subset of cargoes depends on the ArfGAP2/3 Glo3 and ergosterol to maintain their proper localization at the plasma membrane...
  2. Shiba Y, Kametaka S, Waguri S, Presley J, Randazzo P. ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment. Curr Biol. 2013;23:1945-51 pubmed publisher
    ..for ArfGAP3 and dependent on its GAP activity, because the phenotype was rescued by ArfGAP3 but not by ArfGAP1, ArfGAP2, or the GAP domain mutants of ArfGAP3. ArfGAP3 localized to the trans-Golgi network and early endosomes...
  3. Quilty D, Chan C, Yurkiw K, Bain A, Babolmorad G, Melancon P. The Arf-GDP-regulated recruitment of GBF1 to Golgi membranes requires domains HDS1 and HDS2 and a Golgi-localized protein receptor. J Cell Sci. 2018;132: pubmed publisher
    ..Here, we extended our in vivo analysis on the production of regulatory Arf-GDP and observed that ArfGAP2 and ArfGAP3 do not play a role in GBF1 recruitment...
  4. Pevzner I, Strating J, Lifshitz L, Parnis A, Glaser F, Herrmann A, et al. Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. Traffic. 2012;13:849-56 pubmed publisher
    ..Here, we employed recombinant coatomer subcomplexes to study the role of coatomer components in the regulation of ArfGAP2, an ArfGAP whose activity is strictly coatomer-dependent...
  5. Dong J, Li B, Bao Q. In situ reactive zone with modified Mg(OH)2 for remediation of heavy metal polluted groundwater: Immobilization and interaction of Cr(III), Pb(II) and Cd(II). J Contam Hydrol. 2017;199:50-57 pubmed publisher
    ..However, the application of Mg(OH)2 on in situ reactive zone (IRZ) for heavy metal polluted groundwater has never been investigated...
  6. Lian X, Jia Y, Yang Y, Ma Z, Jiang Y, Xi B, et al. Identification of groundwater redox process induced by landfill leachate based on sensitive factor method. Environ Sci Pollut Res Int. 2017;24:27269-27276 pubmed publisher
    ..appeared in pollution plume, including methanogenic zone (MGZ), sulfate reduction zone (SRZ), iron reduction zone (IRZ), nitrate reduction zone (NRZ), and oxygen reduction zone (ORZ)...
  7. Kartberg F, Asp L, Dejgaard S, Smedh M, Fernandez Rodriguez J, Nilsson T, et al. ARFGAP2 and ARFGAP3 are essential for COPI coat assembly on the Golgi membrane of living cells. J Biol Chem. 2010;285:36709-20 pubmed publisher
    ..Two human orthologues of the yeast ARFGAP Glo3p, termed ARFGAP2 and ARFGAP3, have been demonstrated to be present on COPI vesicles generated in vitro in the presence of ..
  8. Saitoh A, Shin H, Yamada A, Waguri S, Nakayama K. Three homologous ArfGAPs participate in coat protein I-mediated transport. J Biol Chem. 2009;284:13948-57 pubmed publisher
    ..Therefore, we also examined ArfGAP2 and ArfGAP3, closely related homologues of ArfGAP1...
  9. Weimer C, Beck R, Eckert P, Reckmann I, Moelleken J, Brugger B, et al. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. J Cell Biol. 2008;183:725-35 pubmed publisher
    ..ArfGAP1 binds to membranes depending on their curvature. In this study, we show that ArfGAP2 and ArfGAP3 do not bind directly to membranes but are recruited via interactions with coatomer...
  10. Schmid E, Ford M, Burtey A, Praefcke G, Peak Chew S, Mills I, et al. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PLoS Biol. 2006;4:e262 pubmed
    ..However, proteins such as beta-arrestin (non-visual arrestin) and autosomal recessive hypercholesterolemia protein, which have direct clathrin interactions, will remain in the coated pits with their interacting receptors...
  11. Ohira M, Morohashi A, Nakamura Y, Isogai E, Furuya K, Hamano S, et al. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. Cancer Lett. 2003;197:63-8 pubmed
    ..We have identified approximately 500 differentially expressed genes between favorable and unfavorable subsets of NBL, among which more than 250 were the genes with unknown function. ..