ARF6

Summary

Gene Symbol: ARF6
Description: ADP ribosylation factor 6
Alias: ADP-ribosylation factor 6
Species: human
Products:     ARF6

Top Publications

  1. Someya A, Sata M, Takeda K, Pacheco Rodriguez G, Ferrans V, Moss J, et al. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc Natl Acad Sci U S A. 2001;98:2413-8 pubmed
    ..ARF-GEP(100) accelerated [(35)S]GTPgammaS binding to ARF1 (class I) and ARF5 (class II) 2- to 3-fold, and to ARF6 (class III) ca. 12-fold...
  2. Orcl L, Palmer D, Amherdt M, Rothman J. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993;364:732-4 pubmed
    ..COP-coated buds may therefore form essentially by self-assembly from Golgi cisternae after an initial step in which GTP is used to allow ARF binding. ..
  3. Martinu L, Masuda Robens J, Robertson S, Santy L, Casanova J, Chou M. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Mol Cell Biol. 2004;24:9752-62 pubmed
    ..we show that TRE17 (also called Tre-2 and USP6), a founding member of the TBC family, targets the Arf family GTPase Arf6, which regulates plasma membrane-endosome trafficking...
  4. Santy L, Ravichandran K, Casanova J. The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol. 2005;15:1749-54 pubmed
    ..b>ARF6 is intimately involved in the regulation of Rac activity; however, the mechanisms by which ARF activation leads to ..
  5. D SOUZA SCHOREY C, Stahl P. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995;221:153-9 pubmed
    ..With the recent evidence that ARF6 localizes to the cell periphery and plays a regulatory role in endocytic traffic, we have investigated the role of ..
  6. Hofmann I, Thompson A, Sanderson C, Munro S. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Curr Biol. 2007;17:711-6 pubmed
    The small GTPase Arf6 regulates endocytosis, actin dynamics, and cell adhesion, and one of its major activators is the exchange factor Arf nucleotide-binding site opener (ARNO), also called cytohesin-2 [1, 2]...
  7. Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, et al. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nat Cell Biol. 2008;10:85-92 pubmed
    ..Overexpression of Arf6 and its effector, AMAP1, correlates with and is crucial for the invasive phenotypes of different breast cancer ..
  8. Austin C, Boehm M, Tooze S. Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3. Biochemistry. 2002;41:4669-77 pubmed
    ..We found that ARF1, ARF5, and ARF6 interacted directly with the beta1-adaptin subunit of AP-1 in the presence of GTPgammaS...
  9. Schweitzer J, D SOUZA SCHOREY C. Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis. J Biol Chem. 2002;277:27210-6 pubmed
    The ARF6 GTPase mediates cell shape changes in interphase cells through its effects on membrane cycling and actin remodeling...

More Information

Publications66

  1. Cavenagh M, Whitney J, Carroll K, Zhang C, Boman A, Rosenwald A, et al. Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane. J Biol Chem. 1996;271:21767-74 pubmed
    ..Subcellular fractionation of cultured mammalian cells allowed the demonstration that Arf6 is uniquely localized to the plasma membranes of Chinese hamster ovary cells...
  2. Hashimoto S, Onodera Y, Hashimoto A, Tanaka M, Hamaguchi M, Yamada A, et al. Requirement for Arf6 in breast cancer invasive activities. Proc Natl Acad Sci U S A. 2004;101:6647-52 pubmed
    ..Here, we found that ADP-ribosylation factor 6 (Arf6) is localized at the invadopodia of the cultured breast cancer cells MDA-MB-231, and its suppression by a small-..
  3. Karim Z, Choi W, Whiteheart S. Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. J Biol Chem. 2008;283:11995-2003 pubmed publisher
    Previous studies showed that ADP-ribosylation factor 6 (Arf6) is important for platelet function; however, little is known about which signaling events regulate this small GTP-binding protein...
  4. Venkateswarlu K, Hanada T, Chishti A. Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B. J Cell Sci. 2005;118:2471-84 pubmed
    ..Finally, we demonstrate that KIF13B binding suppresses the ARF6 GAP activity of centaurin-alpha(1) in intact cells...
  5. Hu B, Shi B, Jarzynka M, Yiin J, D SOUZA SCHOREY C, Cheng S. ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway. Cancer Res. 2009;69:794-801 pubmed publisher
    ..In this study, we report that ADP-ribosylation factor 6 (ARF6), a Ras superfamily small GTPase, is abundantly expressed in invasive human glioma cells...
  6. O Neal C, Jobling M, Holmes R, Hol W. Structural basis for the activation of cholera toxin by human ARF6-GTP. Science. 2005;309:1093-6 pubmed publisher
    ..Crystal structures of a CTA1:ARF6-GTP (guanosine triphosphate) complex reveal that binding of the human activator elicits dramatic changes in CTA1 ..
  7. Blagoveshchenskaya A, Thomas L, Feliciangeli S, Hung C, Thomas G. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell. 2002;111:853-66 pubmed
    ..Here, we show that Nef and PACS-1 combine to usurp the ARF6 endocytic pathway by a PI3K-dependent process and downregulate cell surface MHC-I to the TGN...
  8. Caplan S, Naslavsky N, Hartnell L, Lodge R, Polishchuk R, Donaldson J, et al. A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J. 2002;21:2557-67 pubmed
    ..by a clathrin-independent pathway regulated by the small GTP-binding protein ADP-ribosylation factor 6 (Arf6)...
  9. Frank S, Upender S, Hansen S, Casanova J. ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. J Biol Chem. 1998;273:23-7 pubmed
    ..ARFs 1 and 3 function in the recruitment of coat proteins to membranes of the Golgi apparatus, whereas ARF6 is localized to the plasma membrane, where it appears to modulate both the assembly of the actin cytoskeleton and ..
  10. Jing J, Tarbutton E, Wilson G, Prekeris R. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. Eur J Cell Biol. 2009;88:325-41 pubmed publisher
    ..ADP-ribosylation factor 6 (Arf6) has emerged as master regulator of endocytic membrane traffic and cytoskeletal dynamics during cell movement...
  11. Dunphy J, Moravec R, Ly K, Lasell T, Melancon P, Casanova J. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr Biol. 2006;16:315-20 pubmed
    The small GTPase Arf6 has been shown to regulate the post-endocytic trafficking of a subset of membrane proteins, including beta1 integrins, and inhibition of Arf6 function impairs both cell adhesion and motility...
  12. Maranda B, Brown D, Bourgoin S, Casanova J, Vinay P, Ausiello D, et al. Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. J Biol Chem. 2001;276:18540-50 pubmed
    ..show here that an Arf-nucleotide exchange factor, ARNO (ADP-ribosylation factor nucleotide site opener) as well as Arf6 and Arf1 small GTPases are located in the kidney proximal tubule receptor-mediated endocytosis pathway, and that ..
  13. Klein S, Franco M, Chardin P, Luton F. Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport. J Biol Chem. 2006;281:12352-61 pubmed
    We have analyzed both biochemically and functionally a series of Arf6 mutants, providing new insights into the molecular mode of action of the small G protein Arf6...
  14. Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, et al. GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. PLoS ONE. 2011;6:e23359 pubmed publisher
    Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy.Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis...
  15. Jones C, Nishiya N, London N, Zhu W, Sorensen L, Chan A, et al. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol. 2009;11:1325-31 pubmed publisher
    ..Formation of a Robo4-paxillin complex at the cell surface blocks activation of the small GTPase Arf6 and, consequently, Rac by recruitment of Arf-GAPs (ADP-ribosylation factor- directed GTPase-activating proteins) ..
  16. Sakurai A, Jian X, Lee C, Manavski Y, Chavakis E, Donaldson J, et al. Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein. J Biol Chem. 2011;286:34335-45 pubmed publisher
    ..This process requires the activation of small GTPase Arf6 (ADP-ribosylation factor 6), which regulates intracellular trafficking of ?1 integrin...
  17. Li C, Chiang T, Wu T, Pacheco Rodriguez G, Moss J, Lee F. ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Mol Biol Cell. 2007;18:4420-37 pubmed
    ..opener (ARNO) is a guanine nucleotide-exchange factor (GEF) for ARF, and, at the plasma membrane, it can activate ARF6 to regulate actin reorganization and membrane ruffling...
  18. Langille S, Patki V, Klarlund J, Buxton J, Holik J, Chawla A, et al. ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J Biol Chem. 1999;274:27099-104 pubmed
    ..V., Chawla, A., and Czech, M. P. (1997) Science 275, 1927-1930). Here we show that both endogenous GRP1 and ARF6 rapidly co-localize in plasma membrane ruffles in Chinese hamster ovary (CHO-T) cells expressing human insulin ..
  19. Humphreys D, Davidson A, Hume P, Makin L, Koronakis V. Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proc Natl Acad Sci U S A. 2013;110:16880-5 pubmed publisher
    ..actin assembly mediated by the WASP family veroprolin homolog (WAVE) regulatory complex (WRC), we recapitulated an Arf6-driven actin polymerization pathway...
  20. Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, et al. The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem. 2005;280:21661-6 pubmed
    The small GTP-binding protein ADP-ribosylation factor 6 (Arf6) is involved in plasma membrane/endosomes trafficking. However, precisely how the activation of Arf6 regulates vesicular transport is still unclear...
  21. Poupart M, Fessart D, Cotton M, Laporte S, Claing A. ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin. Cell Signal. 2007;19:2370-8 pubmed
    We have previously shown that the ADP-ribosylation factor 6 (ARF6), a small GTP-binding protein, is important for the internalization of several G protein-coupled receptors...
  22. Houndolo T, Boulay P, Claing A. G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells. J Biol Chem. 2005;280:5598-604 pubmed
    ..Here, we have applied the RNA interference approach to demonstrate that ADP-ribosylation factor 6 (ARF6) is essential for the endocytosis of a broad variety of receptors...
  23. Hashimoto S, Hashimoto A, Yamada A, Kojima C, Yamamoto H, Tsutsumi T, et al. A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function. J Biol Chem. 2004;279:37677-84 pubmed
    Previously we reported that AMAP2/PAG3/Papalpha/KIAA0400, a GTPase-activating protein (GAP), acts to antagonize Arf6 function when overexpressed, whereas it was shown to exhibit efficient GAP activities for other Arf isoforms in vitro...
  24. Rahajeng J, Giridharan S, Cai B, Naslavsky N, Caplan S. MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. Traffic. 2012;13:82-93 pubmed publisher
    ..Moreover, we demonstrate that Arf6 forms a complex with MICAL-L1 and plays a role in its recruitment to tubular endosomes...
  25. Lau A, Chou M. The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. J Cell Sci. 2008;121:4008-17 pubmed publisher
    The ADP-ribosylation factor 6 (Arf6) GTPase functions as a key regulator of endocytic trafficking, participating in clathrin-independent endocytosis in most cell types...
  26. Krauss M, Kinuta M, Wenk M, De Camilli P, Takei K, Haucke V. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. J Cell Biol. 2003;162:113-24 pubmed
    ..We also provide evidence for a role of ADP-ribosylation factor 6 (ARF6) via direct stimulation of a synaptically enriched phosphatidylinositol 4-phosphate 5-kinase type Igamma (..
  27. Takatsu H, Yoshino K, Toda K, Nakayama K. GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. Biochem J. 2002;365:369-78 pubmed
    ..These include ARF1-ARF6, which are divided into three classes on the basis of similarity in the primary structure: Class I, ARF1-ARF3; ..
  28. Yi L, Rosales T, Rose J, Chowdhury B, Chaudhury B, Knutson J, et al. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem. 2010;285:30884-905 pubmed publisher
    ..In all, our data support a model for Nef down-regulation of HLA-I that involves both major trafficking itineraries and persistent protein-protein interactions throughout the cell...
  29. Daher Z, Noël J, Claing A. Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity. Cell Signal. 2008;20:2256-65 pubmed publisher
    ..Here, we show that endothelin-1 (ET-1) can promote the activation of ARF6 and migration of endothelial cells through the activation of ET(B) receptors...
  30. Montagnac G, Sibarita J, Loubéry S, Daviet L, Romao M, Raposo G, et al. ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis. Curr Biol. 2009;19:184-95 pubmed publisher
    ..ADP-ribosylation factor 6 (ARF6), which localizes to the plasma membrane and endosomal compartments, regulates endocytic recycling to the bridge ..
  31. Schweitzer J, Pietrini S, D SOUZA SCHOREY C. ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease. PLoS ONE. 2009;4:e5193 pubmed publisher
    ..Here we report that nucleotide cycling or cellular knockdown of the small GTP-binding protein, ARF6, markedly impacts cholesterol homeostasis...
  32. Li M, Wang J, Ng S, Chan C, He M, Yu F, et al. Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation. Cancer. 2009;115:4959-72 pubmed publisher
    ..The authors previously demonstrated that adenosine diphospate-ribosylation factor 6 (ARF6), a member of the Ras-related small guanosine-5'-triphospate-binding protein family, is required for EFA6A-induced ..
  33. D SOUZA SCHOREY C, Li G, Colombo M, Stahl P. A regulatory role for ARF6 in receptor-mediated endocytosis. Science. 1995;267:1175-8 pubmed
    Adenosine diphosphate-ribosylation factor 6 (ARF6), ARF6 mutants, and ARF1 were transiently expressed in Chinese hamster ovary cells, and the effects on receptor-mediated endocytosis were assessed...
  34. Hurtado Lorenzo A, Skinner M, El Annan J, Futai M, Sun Wada G, Bourgoin S, et al. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol. 2006;8:124-36 pubmed
    The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification...
  35. Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rosse C, et al. ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol. 2003;163:1111-21 pubmed
    ..Here, we show that GTP-bound ARF6 interacts with Sec10, a subunit of the exocyst complex involved in docking of vesicles with the plasma membrane...
  36. Venkateswarlu K, Brandom K, Lawrence J. Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization. J Biol Chem. 2004;279:6205-8 pubmed
    ..Here, we show that centaurin-alpha1 specifically inhibits in vivo GTP loading of ARF6 and redistribution of ARF6 from the endosomal compartment to the plasma membrane, which are indicative of its ..
  37. Larsen J, Massol R, Nieland T, Kirchhausen T. HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity. Mol Biol Cell. 2004;15:323-31 pubmed
    ..Several mutant proteins, including mutations in the small GTPase Arf6, have been used to probe membrane traffic pathways...
  38. D SOUZA SCHOREY C, Boshans R, McDonough M, Stahl P, Van Aelst L. A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 1997;16:5445-54 pubmed
    The ARF6 GTPase, the least conserved member of the ADP ribosylation factor (ARF) family, associates with the plasma membrane and intracellular endosome vesicles...
  39. Yang C, Heimberg H, D SOUZA SCHOREY C, Mueckler M, Stahl P. Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells. J Biol Chem. 1998;273:4006-11 pubmed
    ..In this study, an ARF6-specific monoclonal antibody was raised and used to examine the subcellular distribution and expression of ARF6 in ..
  40. Radhakrishna H, al Awar O, Khachikian Z, Donaldson J. ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci. 1999;112 ( Pt 6):855-66 pubmed
    The ARF6 GTPase regulates a novel endosomal-plasma membrane recycling pathway and influences cortical actin remodeling...
  41. Cotton M, Boulay P, Houndolo T, Vitale N, Pitcher J, Claing A. Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration. Mol Biol Cell. 2007;18:501-11 pubmed
    b>ARF6 and Rac1 are small GTPases known to regulate remodelling of the actin cytoskeleton...
  42. Pasqualato S, Menetrey J, Franco M, Cherfils J. The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2001;2:234-8 pubmed
    The small GTP-binding protein Arf6 coordinates membrane traffic at the plasma membrane with aspects of cytoskeleton organization...
  43. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, et al. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell. 1999;99:521-32 pubmed
    ..In vivo, ARF6, but not ARF1 or ARF5, spatially coincides with PI(4)P5Kalpha...
  44. Shin O, Exton J. Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1. Biochem Biophys Res Commun. 2001;285:1267-73 pubmed
    ..Based on these observations, we suggest that arfaptin 2/POR1 is a target protein for GTP-ARFs and for GDP-Rac1, and that it may be involved in interactions between the Rac and ARF signaling pathways. ..
  45. Caviston J, Cohen L, Donaldson J. Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src. Cytoskeleton (Hoboken). 2014;71:380-94 pubmed publisher
    Arf proteins regulate membrane traffic and organelle structure. Although Arf6 is known to initiate actin-based changes in cell surface architecture, Arf1 may also function at the plasma membrane...
  46. Amor J, Harrison D, Kahn R, Ringe D. Structure of the human ADP-ribosylation factor 1 complexed with GDP. Nature. 1994;372:704-8 pubmed
    ..These features provide a structural basis for the GTP-dependent modulation of membrane affinity, the lack of intrinsic GTPase activity, and the nature of effector binding surfaces. ..
  47. Kanamarlapudi V, Owens S, Saha K, Pope R, Mundell S. ARF6-dependent regulation of P2Y receptor traffic and function in human platelets. PLoS ONE. 2012;7:e43532 pubmed publisher
    ..In this study we investigated the role of the small GTP-binding protein ADP ribosylation factor 6 (ARF6) in the internalization and function of P2Y(1) and P2Y(12) purinoceptors in human platelets...
  48. Kanamarlapudi V, Thompson A, Kelly E, Lopez Bernal A. ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling. J Biol Chem. 2012;287:20443-55 pubmed publisher
    ..However, the mechanisms by which ARF6 and cytohesin 2 regulate LHCGR internalization remain incompletely understood...
  49. al Awar O, Radhakrishna H, Powell N, Donaldson J. Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant. Mol Cell Biol. 2000;20:5998-6007 pubmed
    The ADP-ribosylation factor 6 (ARF6) GTPase has a dual function in cells, regulating membrane traffic and organizing cortical actin...
  50. Claing A, Chen W, Miller W, Vitale N, Moss J, Premont R, et al. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem. 2001;276:42509-13 pubmed
    ..beta-arrestin orchestrates the process of receptor endocytosis through the activation of ADP-ribosylation factor 6 (ARF6), a small GTP-binding protein...
  51. Marchant D, Sall A, Si X, Abraham T, Wu W, Luo Z, et al. ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry. J Gen Virol. 2009;90:854-62 pubmed publisher
    ..ADP-ribosylation factor 6 (Arf6)-dependent endocytosis is another endocytosis pathway that traffics from the cell surface and it is the only Arf ..
  52. Vitale N, Chasserot Golaz S, Bailly Y, Morinaga N, Frohman M, Bader M. Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane. J Cell Biol. 2002;159:79-89 pubmed
    ..Here we show that ARF6 is specifically associated with dense-core secretory granules in neuroendocrine PC12 cells...
  53. Sabe H. Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion. J Biochem. 2003;134:485-9 pubmed
    ..Here the possible roles of a small GTP-binding protein, Arf6, in epithelial cell adhesion and migration, and also in cancer cell invasion, are discussed.
  54. Tague S, Muralidharan V, D SOUZA SCHOREY C. ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway. Proc Natl Acad Sci U S A. 2004;101:9671-6 pubmed
    ..the invasive human melanoma cell line LOX as a model system, we demonstrate that the ADP-ribosylation factor 6 (ARF6) GTPase is an important regulator of invadopodia formation and cell invasion...
  55. Giguère P, Rochdi M, Laroche G, Dupré E, Whorton M, Sunahara R, et al. ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cell Signal. 2006;18:1988-94 pubmed
    ..ADP-Ribosylation Factor 6 (ARF6) plays an important role in GPCR trafficking and is the subject of intense research...
  56. Koo T, Eipper B, Donaldson J. Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol. 2007;8:29 pubmed
    Many studies implicate Arf6 activity in Rac-mediated membrane ruffling and cytoskeletal reorganization...
  57. Kanamarlapudi V, Owens S, Lartey J, Lopez Bernal A. ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies. PLoS ONE. 2012;7:e37954 pubmed publisher
    b>ARF6 (ADP-ribosylation factor 6) small GTP binding protein plays critical roles in actin cytoskeleton rearrangements and membrane trafficking, including internalisation of G protein coupled receptors (GPCR)...