Gene Symbol: ARF1
Description: ADP ribosylation factor 1
Alias: ADP-ribosylation factor 1
Species: human
Products:     ARF1

Top Publications

  1. Gommel D, Memon A, Heiss A, Lottspeich F, Pfannstiel J, Lechner J, et al. Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. EMBO J. 2001;20:6751-60 pubmed
    Binding to Golgi membranes of ADP ribosylation factor 1 (ARF1) is the first event in the initiation of COPI coat assembly. Based on binding studies, a proteinaceous receptor has been proposed to be critical for this process...
  2. Austin C, Boehm M, Tooze S. Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3. Biochemistry. 2002;41:4669-77 pubmed
    ..highly enriched preparation of membranes that has previously been shown to have the membrane-associated factors for ARF1 recruitment that are not present on artificial liposomes...
  3. Joshi A, Garg H, Nagashima K, Bonifacino J, Freed E. GGA and Arf proteins modulate retrovirus assembly and release. Mol Cell. 2008;30:227-38 pubmed publisher
    ..These findings identify the GGA proteins as modulators of HIV-1 release and the Arf proteins as critical cellular cofactors in retroviral Gag trafficking to the plasma membrane. ..
  4. Cukierman E, Huber I, Rotman M, Cassel D. The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science. 1995;270:1999-2002 pubmed
    ..triphosphate (GTP) by the small guanosine triphosphatase (GTPase) adenosine diphosphate ribosylation factor-1 (ARF1) depends on a GTPase-activating protein (GAP)...
  5. Mossessova E, Corpina R, Goldberg J. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell. 2003;12:1403-11 pubmed
    ..Brefeldin A (BFA) is a fungal metabolite that binds to the ARF1*GDP*Sec7 complex and blocks GEF activity at an early stage of the reaction, prior to guanine nucleotide release...
  6. Bigay J, Gounon P, Robineau S, Antonny B. Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. Nature. 2003;426:563-6 pubmed
    ..cycle of the COPI coat on Golgi membranes is coupled to the GTP/GDP cycle of the small G protein Arf1. At the heart of this coupling is the specific interaction of membrane-bound Arf1-GTP with coatomer, a complex of ..
  7. Szul T, Grabski R, Lyons S, Morohashi Y, Shestopal S, Lowe M, et al. Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking. J Cell Sci. 2007;120:3929-40 pubmed
    ..However, the trafficking of transmembrane proteins through the existing pathway requires GBF1-mediated ARF activation and COPI recruitment. ..
  8. Viaud J, Zeghouf M, Barelli H, Zeeh J, Padilla A, Guibert B, et al. Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes. Proc Natl Acad Sci U S A. 2007;104:10370-5 pubmed
    ..Here we target the activation of the small GTP-binding protein Arf1, a major regulator of membrane traffic, by the Sec7 catalytic domain of its guanine nucleotide exchange factor ARNO...
  9. Boulay P, Schlienger S, Lewis Saravalli S, Vitale N, Ferbeyre G, Claing A. ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein. Oncogene. 2011;30:3846-61 pubmed publisher
    ..In this study, we report that ARF1 has a critical role in cell proliferation...

More Information


  1. Boehm M, Aguilar R, Bonifacino J. Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs). EMBO J. 2001;20:6265-76 pubmed
    ..we show that the recruitment of endogenous AP-4 to the TGN in vivo is regulated by the small GTP-binding protein ARF1. In addition, we demonstrate a direct interaction of the epsilon and mu4 subunits of AP-4 with ARF1...
  2. Lundmark R, Doherty G, Vallis Y, Peter B, McMahon H. Arf family GTP loading is activated by, and generates, positive membrane curvature. Biochem J. 2008;414:189-94 pubmed publisher
    ..b>Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, ..
  3. Beck R, Sun Z, Adolf F, Rutz C, Bassler J, Wild K, et al. Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A. 2008;105:11731-6 pubmed publisher
    The GTPase Arf1 is considered as a molecular switch that regulates binding and release of coat proteins that polymerize on membranes to form transport vesicles...
  4. Koch T, Brandenburg L, Schulz S, Liang Y, Klein J, Hollt V. ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis. J Biol Chem. 2003;278:9979-85 pubmed
    ..Together, these data suggest that PLD2 play a key role in the regulation of agonist-induced endocytosis of the mu-opioid receptor. ..
  5. Dell Angelica E, Puertollano R, Mullins C, Aguilar R, Vargas J, Hartnell L, et al. GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol. 2000;149:81-94 pubmed
    ..Treatment with brefeldin A or overexpression of dominant-negative ADP ribosylation factor 1 (ARF1) caused dissociation of GGAs from membranes...
  6. Ben Tekaya H, Kahn R, Hauri H. ADP ribosylation factors 1 and 4 and group VIA phospholipase A? regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment. Mol Biol Cell. 2010;21:4130-40 pubmed publisher
    ..In search of morphological determinants for the ERGIC, we found that a double knockdown of Arf1+Arf4 induced dynamic ERGIC tubules that connect ERGIC clusters, indicating that the tubules mediated lateral ..
  7. Matto M, Sklan E, David N, Melamed Book N, Casanova J, Glenn J, et al. Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication. J Virol. 2011;85:946-56 pubmed publisher
    We hypothesized that ADP-ribosylation factor 1 (Arf1) plays an important role in the biogenesis and maintenance of infectious hepatitis C virus (HCV). Huh7...
  8. Ellong E, Soni K, Bui Q, Sougrat R, Golinelli Cohen M, Jackson C. Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1. PLoS ONE. 2011;6:e21889 pubmed publisher
    The Arf1 exchange factor GBF1 (Golgi Brefeldin A resistance factor 1) and its effector COPI are required for delivery of ATGL (adipose triglyceride lipase) to lipid droplets (LDs)...
  9. Frank S, Upender S, Hansen S, Casanova J. ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. J Biol Chem. 1998;273:23-7 pubmed
    ..Recently, ARNO and its close homologue cytohesin-1 were found to catalyze in vitro nucleotide exchange on ARF1 and ARF3, respectively, raising the possibility that these GEFs function in the Golgi...
  10. Schekman R, Orci L. Coat proteins and vesicle budding. Science. 1996;271:1526-33 pubmed
    ..Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface...
  11. Kondo Y, Hanai A, Nakai W, Katoh Y, Nakayama K, Shin H. ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway. Cell Struct Funct. 2012;37:141-54 pubmed
    Small GTPases ARF1 and ARF3 localize mainly to the Golgi apparatus, where they trigger formation of coated carrier vesicles...
  12. Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brugger B, et al. Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic. 2007;8:582-93 pubmed
    The small GTPase ADP-ribosylation factor-1 (Arf1) plays a key role in the formation of coat protein I (COP I)-coated vesicles...
  13. Serafini T, Orci L, Amherdt M, Brunner M, Kahn R, Rothman J. ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell. 1991;67:239-53 pubmed
    ..These observations strongly suggest a new role for GTP-binding proteins: ARF proteins may modulate vesicle budding and uncoating through controlled GTP hydrolysis. ..
  14. Beemiller P, Hoppe A, Swanson J. A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis. PLoS Biol. 2006;4:e162 pubmed
    ..A (BFA), an inhibitor of certain ARF guanine nucleotide exchange factors (GEFs), previously indicated that ARF1 did not participate in phagocytosis...
  15. Renault L, Guibert B, Cherfils J. Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. Nature. 2003;426:525-30 pubmed
    ..The structural characteristics of the reaction and its modes of inhibition reveal unexplored ways in which to inhibit the activation of small G proteins. ..
  16. Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi D, Kular G, et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004;6:393-404 pubmed
    ..Moreover, overexpression of FAPP-PH impairs carrier fission. Therefore, FAPPs are essential components of a PtdIns(4)P- and ARF-regulated machinery that controls generation of constitutive post-Golgi carriers...
  17. Takatsu H, Yoshino K, Toda K, Nakayama K. GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. Biochem J. 2002;365:369-78 pubmed
    ..These include ARF1-ARF6, which are divided into three classes on the basis of similarity in the primary structure: Class I, ARF1-ARF3; ..
  18. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, et al. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell. 1999;99:521-32 pubmed
    ..In vivo, ARF6, but not ARF1 or ARF5, spatially coincides with PI(4)P5Kalpha...
  19. Peyroche A, Antonny B, Robineau S, Acker J, Cherfils J, Jackson C. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol Cell. 1999;3:275-85 pubmed
    ..We show that the target of BFA inhibition of ARF exchange activity is an ARF-GDP-Sec7 domain protein complex, and that BFA acts to stabilize this complex to a greater extent for a BFA-sensitive Sec7 domain than for a resistant one. ..
  20. Goldberg J. Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. Cell. 1999;96:893-902 pubmed
    The crystal structure of the complex of ARF1 GTPase bound to GDP and the catalytic domain of ARF GTPase-activating protein (ARFGAP) has been determined at 1.95 A resolution...
  21. Zhang L, Hong Z, Lin W, Shao R, Goto K, Hsu V, et al. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS ONE. 2012;7:e32135 pubmed publisher
    ..Moreover, the vesicular transport proteins ARF1 and GBF1 colocalized with PI4KIII? and were both required for HCV replication...
  22. Dascher C, Balch W. Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus. J Biol Chem. 1994;269:1437-48 pubmed
    Using three different trans dominant mutants of bovine ARF1 affecting GDP exchange or GTP hydrolysis we demonstrate the central role of ARF1 in controlling vesicular traffic from the endoplasmic reticulum (ER) to the Golgi apparatus and ..
  23. Lewis Saravalli S, Campbell S, Claing A. ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells. Cell Signal. 2013;25:1813-9 pubmed publisher
    ..We have previously shown that ARF1 is overexpressed in highly invasive breast cancer cells and contribute to their enhanced migration...
  24. Krauss M, Jia J, Roux A, Beck R, Wieland F, De Camilli P, et al. Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding. J Biol Chem. 2008;283:27717-23 pubmed publisher
    ..Here we report that Arf1 is found on membrane tubules originating from the Golgi complex where it colocalizes with COPI and GGA1 vesicle ..
  25. Boulay P, Cotton M, Melancon P, Claing A. ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells. J Biol Chem. 2008;283:36425-34 pubmed publisher
    ..Using an invasive breast cancer cell lines, we demonstrate that the ADP-ribosylation factor 1 (ARF1), a small GTPase classically associated with the Golgi, is an important regulator of the biological effects induced ..
  26. Ménétrey J, Perderiset M, Cicolari J, Dubois T, Elkhatib N, El Khadali F, et al. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J. 2007;26:1953-62 pubmed
    ..ARHGAP21 is recruited to the Golgi by binding to another small GTPase, ARF1. Here, we present the crystal structure of the activated GTP-bound form of ARF1 in a complex with the Arf-binding ..
  27. Stearns T, Willingham M, Botstein D, Kahn R. ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Proc Natl Acad Sci U S A. 1990;87:1238-42 pubmed
    ..Yeast cells bearing an arf1 null mutation display a number of phenotypes suggesting a defect in the secretory pathway...
  28. Faure J, Stalder R, Borel C, Sobo K, Piguet V, Demaurex N, et al. ARF1 regulates Nef-induced CD4 degradation. Curr Biol. 2004;14:1056-64 pubmed
    ..Here we report that the small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4...
  29. Majoul I, Straub M, Hell S, Duden R, Söling H. KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. Dev Cell. 2001;1:139-53 pubmed
    ..of ERD2 and recruitment of ARFGAP to the Golgi, where the (ERD2)n/ARFGAP complex interacts with membrane-bound ARF1. During KDEL ligand transport, interactions of ERD2 with beta-COP and p23 decrease and the proteins segregate...
  30. Puertollano R, Randazzo P, Presley J, Hartnell L, Bonifacino J. The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell. 2001;105:93-102 pubmed
    ..Here, we show that binding of the GAT domain stabilizes membrane-bound ARF1.GTP due to interference with the action of GTPase-activating proteins...
  31. Amor J, Harrison D, Kahn R, Ringe D. Structure of the human ADP-ribosylation factor 1 complexed with GDP. Nature. 1994;372:704-8 pubmed
    ..Here we report the three-dimensional structure of full-length human ARF1 (M(r) 21,000) in its GDP-bound non-myristoylated form...
  32. Zhao L, Helms J, Brunner J, Wieland F. GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. J Biol Chem. 1999;274:14198-203 pubmed
  33. Claude A, Zhao B, Kuziemsky C, Dahan S, Berger S, Yan J, et al. GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. J Cell Biol. 1999;146:71-84 pubmed
    ..Immunogold labeling showed highest density of GBF1 over Golgi cisternae and significant labeling over pleiomorphic smooth vesiculotubular structures. The BFA-resistant nature of GBF1 suggests involvement in retrograde traffic...
  34. Liang X, Sun H, Shen W, Wang S, Yao J, Migawa M, et al. Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels. Nucleic Acids Res. 2017;45:9528-9546 pubmed publisher
    ..Levels of human RNASEH1, LDLR, and ACP1 and of mouse ACP1 and ARF1 were increased up to 2...
  35. Koubek E, Santy L. ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation. Small Gtpases. 2018;9:242-259 pubmed publisher
    ..Previously, the role of ARF6 in this process was unclear. We have now found that ARF6 and ARF1 regulate trafficking of GRASP and Dock180 to the plasma membrane following HGF treatment...
  36. Slomiany B, Slomiany A. Role of protein kinase D2 phosphorylation on Tyr in modulation by ghrelin of Helicobacter pylori-induced up-regulation in gastric mucosal matrix metalloproteinase-9 (MMP-9) secretion. Inflammopharmacology. 2016;24:119-26 pubmed publisher
    ..Further, we demonstrate that the LPS effect is associated with up-regulation in the activation of Arf1, a small GTPase of the ADP-ribosylation factor family, and the recruitment and phosphorylation of protein kinase D2 ..
  37. Kanoh H, Williger B, Exton J. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. J Biol Chem. 1997;272:5421-9 pubmed
    ..arfaptin 1 was ubiquitously expressed, and recombinant arfaptin 1 bound preferentially to class I ARFs, especially ARF1, but only in the GTP-bound form. The interactions were independent of myristoylation of ARF...
  38. Zhang N, Zhang L. Key components of COPI and COPII machineries are required for chikungunya virus replication. Biochem Biophys Res Commun. 2017;493:1190-1196 pubmed publisher
    ..Moreover, CHIKV infection is abolished by the presence of ARF1 inhibitor brefeldin A or GBF1 inhibitor golgicide A...
  39. Khadilkar R, Ray A, Chetan D, Sinha A, Magadi S, Kulkarni V, et al. Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis. Sci Rep. 2017;7:118 pubmed publisher
    ..We show that the ubiquitous trafficking protein ADP Ribosylation Factor 1 (ARF1) and the hemocyte-specific endosomal regulator Asrij differentially regulate humoral immunity...
  40. Christis C, Munro S. The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. J Cell Biol. 2012;196:327-35 pubmed publisher
    The small G protein Arf1 regulates Golgi traffic and is activated by two related types of guanine nucleotide exchange factor (GEF). GBF1 acts at the cis-Golgi, whereas BIG1 and its close paralog BIG2 act at the trans-Golgi...
  41. Daher Z, Boulay P, Desjardins F, Gratton J, Claing A. Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells. J Biol Chem. 2010;285:24591-9 pubmed publisher
    ..Our results show that this growth factor can promote the rapid and transient activation of ARF1. In endothelial cells, this GTPase is present on dynamic plasma membrane ruffles...
  42. Liu Y, Kahn R, Prestegard J. Structure and membrane interaction of myristoylated ARF1. Structure. 2009;17:79-87 pubmed publisher
    ..Here we present the structure of a myristoylated ARF1 protein, determined by solution NMR methods, and an assessment of the influence of myristoylation on association of ..
  43. Collins B, Watson P, Owen D. The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs. Dev Cell. 2003;4:321-32 pubmed
    ..Structure-based mutagenesis demonstrates that ARF1-GTP binding by GGAs is exclusively governed by the N-terminal "hook" subdomain, and, using an in vitro ..
  44. Takeya R, Takeshige K, Sumimoto H. Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. Biochem Biophys Res Commun. 2000;267:149-55 pubmed
    ..On the other hand, the PDZ domain of PICK1 is capable of interacting with constitutively active, GTP-bound forms of ARF1 and ARF3, but neither with those of ARF5/6 nor with the GDP-bound ARFs...
  45. Yamayoshi S, Neumann G, Kawaoka Y. Role of the GTPase Rab1b in ebolavirus particle formation. J Virol. 2010;84:4816-20 pubmed publisher
    ..Activated GBF1 stimulates ARF1 (ADP ribosylation factor 1), which recruits coat protein to cellular membranes for the assembly of COPI vesicles...
  46. Kim B, Satchell K. MARTX effector cross kingdom activation by Golgi-associated ADP-ribosylation factors. Cell Microbiol. 2016;18:1078-93 pubmed publisher
    ..DmXVv was found to localize to Golgi and to directly interact with Golgi-associated ADP-ribosylation factors ARF1, ARF3 and ARF4, although ARF binding was not necessary for the subcellular localization...
  47. Casey C, Bhat G, Holzapfel M, Petrosyan A. Study of Ethanol-Induced Golgi Disorganization Reveals the Potential Mechanism of Alcohol-Impaired N-Glycosylation. Alcohol Clin Exp Res. 2016;40:2573-2590 pubmed publisher
    ..including electron microscopy, we revealed that EtOH treatment results in dysfunction of ADP-ribosylation factor 1 (Arf1) GTPase followed by a deficiency in COPI vesicles at the Golgi...
  48. Ghosh M, Weghorst K, Berberich S. MdmX inhibits ARF mediated Mdm2 sumoylation. Cell Cycle. 2005;4:604-8 pubmed
    ..Taken together, these results demonstrate that MdmX can affect post-translational modification and stability of Mdm2 and p53 activity through interaction with ARF. ..
  49. Schlienger S, Campbell S, Claing A. ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion. Mol Biol Cell. 2014;25:17-29 pubmed publisher
    ..Although we have showed that the GTPase ADP-ribosylation factor 1 (ARF1) is overexpressed in highly invasive breast cancer cell lines and that epidermal growth factor stimulation can ..
  50. Hansen M, Johnsen I, Stiberg K, Sherstova T, Wakita T, Richard G, et al. Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Proc Natl Acad Sci U S A. 2017;114:E3462-E3471 pubmed publisher
    ..Collectively, our results identify IRGM as a key Golgi-situated regulator that links intracellular membrane remodeling by autophagy and Golgi fragmentation with viral replication. ..
  51. Kim J, Noh S, Piao H, Kim D, Kim K, Cha J, et al. Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR. Traffic. 2016;17:733-53 pubmed publisher
    ..ER by stimuli that induce unconventional secretion of ?F508-CFTR, such as induction of ER-to-Golgi blockade by the Arf1 mutant...
  52. Ejzykowicz D, Locken K, Ruiz F, Manandhar S, Olson D, Gharakhanian E. Hygromycin B hypersensitive (hhy) mutants implicate an intact trans-Golgi and late endosome interface in efficient Tor1 vacuolar localization and TORC1 function. Curr Genet. 2017;63:531-551 pubmed publisher increased sensitivity to translation inhibition and establish a super HHY (s-HHY) subgroup of genes comprised of ARF1, CHC1, DRS2, SAC1, VPS1, VPS34, VPS45, VPS52, and VPS54 that function exclusively or inclusively at trans-Golgi and ..
  53. Wang Y, Zhang H, Shi M, Liou Y, Lu L, Yu F. Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Development. 2017;144:1851-1862 pubmed publisher
    ..Here, we show that the small GTPase Arf1, an important regulator of the secretory pathway, is specifically required for dendrite pruning of ddaC/D/E sensory ..
  54. Jian X, Cavenagh M, Gruschus J, Randazzo P, Kahn R. Modifications to the C-terminus of Arf1 alter cell functions and protein interactions. Traffic. 2010;11:732-42 pubmed publisher
    ..Here, we have characterized the effect of C-terminal tagging of Arf1 on (i) function in Saccharomyces cerevisiae, (ii) in vitro nucleotide exchange and (iii) interaction with guanine ..
  55. Southon A, Greenough M, Hung Y, Norgate M, Burke R, Camakaris J. The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake. Int J Biochem Cell Biol. 2011;43:146-53 pubmed publisher
    ..The ADP-ribosylation factor 1 (Arf1) is required for maintenance of Golgi architecture and for vesicular trafficking, including the copper-responsive ..
  56. Rai P, Kumar M, Sharma G, Barak P, Das S, Kamat S, et al. Kinesin-dependent mechanism for controlling triglyceride secretion from the liver. Proc Natl Acad Sci U S A. 2017;114:12958-12963 pubmed publisher
    ..We show that kinesin motors are recruited to triglyceride-rich lipid droplets (LDs) in the liver by the GTPase ARF1, which is a key activator of lipolysis...
  57. Verheije M, Raaben M, Mari M, te Lintelo E, Reggiori F, van Kuppeveld F, et al. Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. PLoS Pathog. 2008;4:e1000088 pubmed publisher
    ..Consistently, expression of a dominant-negative mutant of ARF1, known to mimic the action of the drug, inhibited MHV infection profoundly...
  58. Mitchell R, Robertson D, Holland P, Collins D, Lutz E, Johnson M. ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. J Biol Chem. 2003;278:33818-30 pubmed
    ..Experiments with mutant constructs of ARF1/6 and PLD1/2 indicate that the M3 receptor displays a major ARF1-dependent route of PLD1 activation with an ..
  59. Song O, Queval C, Iantomasi R, Delorme V, Marion S, Veyron Churlet R, et al. ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. EMBO Rep. 2018;19:29-42 pubmed publisher
    ..cells requires rearrangements of the actin cytoskeleton, which are regulated by ADP-ribosylation factor 1 (Arf1) and phospholipase D1 (PLD1), and is dependent on the M3 muscarinic receptor (M3R)...
  60. Hirst J, Lindsay M, Robinson M. GGAs: roles of the different domains and comparison with AP-1 and clathrin. Mol Biol Cell. 2001;12:3573-88 pubmed
    ..Together with results from other studies, our findings suggest that the GGAs act as monomeric adaptors, with the four domains involved in cargo selection, membrane localization, clathrin binding, and accessory protein recruitment. ..
  61. Xie X, Tang S, Cai Y, Pi W, Deng L, Wu G, et al. Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1. Oncotarget. 2016;7:58111-58120 pubmed publisher
    ..We report for the first time that ADP-ribosylation factor 1 (ARF1) is the most amplified gene in ARF gene family in breast cancer, and high-level amplification of ARF1 is associated ..
  62. Hanai A, Ohgi M, Yagi C, Ueda T, Shin H, Nakayama K. Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. J Biochem. 2016;159:201-8 pubmed publisher
    ..We here show that, in addition to Arf6, Class I Arfs (Arf1 and Arf3) are localized to the Flemming body, and that double knockdown of Arf1 and Arf3 moderately increases the ..
  63. Padovani D, Folly Klan M, Labarde A, Boulakirba S, Campanacci V, Franco M, et al. EFA6 controls Arf1 and Arf6 activation through a negative feedback loop. Proc Natl Acad Sci U S A. 2014;111:12378-83 pubmed publisher
    ..We found that EFA6 has a previously unappreciated high efficiency toward Arf1 on membranes and that, similar to BRAGs, its PH domain is not autoinhibitory and strongly potentiates nucleotide ..
  64. Franckenberg S, Becker T, Beckmann R. Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue. Curr Opin Struct Biol. 2012;22:786-96 pubmed publisher
    ..Both termination and ribosome rescue are mediated by class I release factors (eRF1/aRF1 in eukaryotic/archaeal termination) or their paralogs (Pelota/aPelota for ribosome rescue) and homologs of ..
  65. Jones D, Morris J, Morgan C, Kondo H, Irvine R, Cockcroft S. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. J Biol Chem. 2000;275:13962-6 pubmed
    ..and a pool of phosphatidylinositol phosphate (PIP), which is further increased by ADP-ribosylation factor 1 (ARF1)...
  66. Tsai M, Lin P, Cheng W, Tsai C, Chi H, Chen C, et al. Overexpression of ADP-ribosylation factor 1 in human gastric carcinoma and its clinicopathological significance. Cancer Sci. 2012;103:1136-44 pubmed publisher
    ..ADP-ribosylation factor 1 (ARF1) was initially identified using 2-D electrophoresis combined with MALDI-time-of-flight mass spectrometry...
  67. Pacheco Rodriguez G, Patton W, Adamik R, Yoo H, Lee F, Zhang G, et al. Structural elements of ADP-ribosylation factor 1 required for functional interaction with cytohesin-1. J Biol Chem. 1999;274:12438-44 pubmed
    ADP-ribosylation factor 1 (ARF1) is a 20-kDa guanine nucleotide-binding protein involved in vesicular trafficking. Conversion of inactive ARF-GDP to active ARF-GTP is catalyzed by guanine nucleotide exchange proteins such as cytohesin-1...
  68. Lee S, Park J, Kim Y, Kim J, Shin K, Lee J, et al. Actin directly interacts with phospholipase D, inhibiting its activity. J Biol Chem. 2001;276:28252-60 pubmed
    ..reported that alpha-actinin inhibited PLD2 activity in an interaction-dependent and an ADP-ribosylation factor 1 (ARF1)-reversible manner (Park, J. B., Kim, J. H., Kim, Y., Ha, S. H., Kim, J. H., Yoo, J.-S., Du, G., Frohman, M. A...
  69. Schlienger S, Campbell S, Pasquin S, Gaboury L, Claing A. ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer. Oncotarget. 2016;7:15811-27 pubmed publisher
    ..However, the importance of this GTPase, in vivo, remains to be demonstrated. We report that ARF1 is highly expressed in breast tumors of the most aggressive and advanced subtypes...
  70. Caviston J, Cohen L, Donaldson J. Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src. Cytoskeleton (Hoboken). 2014;71:380-94 pubmed publisher
    ..Although Arf6 is known to initiate actin-based changes in cell surface architecture, Arf1 may also function at the plasma membrane...
  71. Bobak D, Nightingale M, Murtagh J, Price S, Moss J, Vaughan M. Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin. Proc Natl Acad Sci U S A. 1989;86:6101-5 pubmed
    ..Two ARF cDNAs, ARF1 and ARF3, were cloned from a human cerebellum library...
  72. Lu L, Khan A, Walker W. ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1221-9 pubmed publisher
    ..Here we demonstrated that ARF1 may play a critical role in clathrin-mediated CT trafficking through the endoplasmic reticulum and Golgi and that ..