ARCN1

Summary

Gene Symbol: ARCN1
Description: archain 1
Alias: COPD, archain vesicle transport protein 1, coatomer delta subunit, coatomer protein complex, subunit delta, coatomer protein delta-COP, coatomer subunit delta, delta-COP, delta-coat protein
Species: human

Top Publications

  1. ncbi [Quality of life in patients with chronic obstructive lung diseases: psychometric criteria of the German version of the Sickness Impact Profile and initial results of its application]
    B O Hütter
    Neurochirurgische Klinik, Medizinische Fakultat, Technischen Hochschule, Aachen
    Pneumologie 51:108-14. 1997
  2. ncbi A multivariate model for predicting respiratory status in patients with chronic obstructive pulmonary disease
    G H Murata
    Veterans Affairs Medical Center, and the Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87108, USA
    J Gen Intern Med 13:462-8. 1998
  3. ncbi [Relevance of deep venous thrombosis of the leg in patients with acute exacerbated COPD]
    B Schonhofer
    Krankenhaus Kloster Grafschaft, Zentrum fur Pneumologie, Beatmungs und Schlafmedizin, Schmallenberg Grafschaft
    Pneumologie 53:10-4. 1999
  4. ncbi The impact of spinal problems on the health status of patients: have we underestimated the effect?
    J C Fanuele
    Department of Surgery, Section of Orthopaedics, and Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
    Spine (Phila Pa 1976) 25:1509-14. 2000
  5. ncbi In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus
    J M Geraci
    Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
    J Gen Intern Med 10:307-14. 1995
  6. ncbi Factors predicting readmission of older general medicine patients
    R Burns
    Section of Geriatric Medicine, Veterans Affairs Medical Center, Memphis, TN 38104
    J Gen Intern Med 6:389-93. 1991
  7. ncbi [Functional capacity (dyspnea) and quality of life in patients with chronic obstructive lung disease (COPD): instruments of assessment and methodological aspects]
    B O Hütter
    Neurochirurgische Klinik, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule RWTH Aachen
    Pneumologie 53:133-42. 1999
  8. ncbi [Cardiopulmonary risk factors in patients with sleep apnea]
    I Fett
    Klinische Zeitreihenanalyse,
    Pneumologie 45:265-70. 1991
  9. ncbi [Quantitative computerized tomography of the lung--respiration controlled diagnosis of diffuse lung diseases]
    T Beinert
    , Klinikum Grosshadern, Medizinische Klinik I,
    Pneumologie 49:678-83. 1995
  10. ncbi [N-acetylcysteine: a functional oxygen radical scavenger in vitro and ex vivo in monocytes and neutrophilic granulocytes of patients with COPD]
    M Jaworska
    , , Bochum
    Pneumologie 49:539-45. 1995

Research Grants

  1. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
  2. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
  3. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2010
  4. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2009
  5. COPD Clinical Research Network
    Frank Sciurba; Fiscal Year: 2007
  6. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
  7. Depression and functional outcomes in COPD: Impact of genetics and inflammation
    HUONG Q contact NGUYEN; Fiscal Year: 2010
  8. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2009
  9. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
  10. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2007

Detail Information

Publications189 found, 100 shown here

  1. ncbi [Quality of life in patients with chronic obstructive lung diseases: psychometric criteria of the German version of the Sickness Impact Profile and initial results of its application]
    B O Hütter
    Neurochirurgische Klinik, Medizinische Fakultat, Technischen Hochschule, Aachen
    Pneumologie 51:108-14. 1997
    ..Therefore, we developed a German version of the SIP and investigated its psychometric properties in patients with chronic obstructive lung disease (COPD).
  2. ncbi A multivariate model for predicting respiratory status in patients with chronic obstructive pulmonary disease
    G H Murata
    Veterans Affairs Medical Center, and the Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87108, USA
    J Gen Intern Med 13:462-8. 1998
    ..model for predicting respiratory status in patients with advanced chronic obstructive pulmonary disease (COPD). DESIGN: Prospective, double-blind study of peak flow monitoring...
  3. ncbi [Relevance of deep venous thrombosis of the leg in patients with acute exacerbated COPD]
    B Schonhofer
    Krankenhaus Kloster Grafschaft, Zentrum fur Pneumologie, Beatmungs und Schlafmedizin, Schmallenberg Grafschaft
    Pneumologie 53:10-4. 1999
    Acute exacerbation of chronic obstructive pulmonary disease (COPD) is associated with dyspnoea and, consequently, reduced mobility...
  4. ncbi The impact of spinal problems on the health status of patients: have we underestimated the effect?
    J C Fanuele
    Department of Surgery, Section of Orthopaedics, and Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
    Spine (Phila Pa 1976) 25:1509-14. 2000
    ..A prospective study of 17,774 patients who consulted spine centers in which the impact of spinal disorders and comorbidities on physical functional status were evaluated...
  5. ncbi In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus
    J M Geraci
    Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
    J Gen Intern Med 10:307-14. 1995
    ..among survivors of inpatient treatment for congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), or diabetes mellitus (DM). DESIGN: Retrospective cohort study...
  6. ncbi Factors predicting readmission of older general medicine patients
    R Burns
    Section of Geriatric Medicine, Veterans Affairs Medical Center, Memphis, TN 38104
    J Gen Intern Med 6:389-93. 1991
    ..were emergently admitted and more severely ill, had more diagnoses of chronic obstructive pulmonary disease (COPD) or congestive heart failure (CHF), less ischemic heart disease, and more hospitalizations and hospital days in the ..
  7. ncbi [Functional capacity (dyspnea) and quality of life in patients with chronic obstructive lung disease (COPD): instruments of assessment and methodological aspects]
    B O Hütter
    Neurochirurgische Klinik, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule RWTH Aachen
    Pneumologie 53:133-42. 1999
    ..for the assessment of disease impact and treatment outcome in patients with chronic obstructive pulmonary disease (COPD)...
  8. ncbi [Cardiopulmonary risk factors in patients with sleep apnea]
    I Fett
    Klinische Zeitreihenanalyse,
    Pneumologie 45:265-70. 1991
    ..as obesity, hypertension, coronary heart disease (CHD), heart insufficiency, chronic obstructive pulmonary disease (COPD), and daytime hypoxaemia...
  9. ncbi [Quantitative computerized tomography of the lung--respiration controlled diagnosis of diffuse lung diseases]
    T Beinert
    , Klinikum Grosshadern, Medizinische Klinik I,
    Pneumologie 49:678-83. 1995
    ..computed tomography (HRCT) in 26 healthy volunteers, 15 patients with chronic obstructive pulmonary disease (COPD), and 15 patients with idiopathic lung fibrosis (IPF)...
  10. ncbi [N-acetylcysteine: a functional oxygen radical scavenger in vitro and ex vivo in monocytes and neutrophilic granulocytes of patients with COPD]
    M Jaworska
    , , Bochum
    Pneumologie 49:539-45. 1995
    ..freshly isolated and ex vivo cultured mononuclear (MN) and polymorphonuclear cells (PMN) derived from patients with COPD (smoker, n = 30)...
  11. ncbi [Effect of salmeterol in obstructive sleep apnea syndrome]
    K Rasche
    , Allergologie und Schlafmedizin, Berufsgenossenschaftliche Kliniken Bergmannsheil,
    Pneumologie 52:11-3. 1998
    ..m-2; apnoea hypopnoea index (AHI) 35.6 +/- 17.8 h-1. Patients with asthma, chronic obstructive pulmonary disease (COPD), and left heart failure were excluded. Placebo or verum (50 micrograms Salmeterol) were administered at 7 p.m...
  12. ncbi Analysis of antioxidant enzyme activity and magnesium level in chronic obstructive pulmonary disease (COPD)
    E Kurys
    Department of Pulmonary Diseases and Tuberculosis, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:261-6. 2001
    ..to be clinically relevant to assess prooxidant/antioxidant balance and its correlation with magnesium level in COPD. In this study, there were investigated the antioxidant enzymes activity and magnesium plasma level in a group of ..
  13. ncbi Chronic obstructive pulmonary disease in blacks and whites: pulmonary function norms and risk factors
    R F Gillum
    Office of Analysis and Epidemiology, National Center for Health Statistics, Hyattsville, Maryland 20782
    J Natl Med Assoc 83:393-401. 1991
    Chronic obstructive pulmonary disease (COPD) and asthma are significant causes of illness and death in blacks. Racial differences in normal values of pulmonary function tests must be considered in both patient care and research...
  14. ncbi [Bilateral lung volume reduction in patients with severe pulmonary emphysema]
    G Stamatis
    , Ruhrlandklinik, Essen
    Pneumologie 50:448-52. 1996
    For selected patients with severe pulmonary obstructive disease (COPD) and dyspnea despite conservative treatment, lung volume reduction (LVR) may to be of significant value as a surgical option...
  15. ncbi [Stress test blood gas analysis in chronic obstructive lung diseases]
    K Rasche
    ,
    Pneumologie 51:640-6. 1997
    This study was conducted to investigate the clinical value of blood gas analysis during exercise in patients with COPD and healthy controls using the new criteria of the Deutsche Gesellschaft für Pneumologie (DGP) for performance and ..
  16. ncbi Chronic obstructive pulmonary disease in blacks and whites: mortality and morbidity
    R F Gillum
    Office of Analysis and Epidemiology, National Center for Health Statistics, Hyattsville, MD 20782
    J Natl Med Assoc 82:417-28. 1990
    Previous reports cite puzzling racial differences in several indicators of chronic obstructive pulmonary disease (COPD)...
  17. ncbi [Effect of oxygen (FI02: 0.35) on the aerobic capacity in patients with COPD]
    J Fichter
    Paracelsus Klinik, Innere Medizin,
    Pneumologie 53:121-6. 1999
    ..MEASUREMENTS: Ten male patients with COPD (mean FEV1 = 43.2 +/- 17...
  18. ncbi [The significance of health related quality of life for the evaluation of interventional measures in patients with COPD]
    G Würtemberger
    Abteilung fur Innere Medizin, Pneumologie, Reha Zentrum Reichshof, Reichshof Eckenhagen
    Pneumologie 55:91-9. 2001
    ..criterion for the evaluation of rehabilitation measures in patients with chronic obstructive pulmonary disease (COPD)...
  19. ncbi [Functional effects of different training in patients with COPD]
    G Würtemberger
    Abteilung für Innere Medizin Pneumologie, Reha Zentrum Reichshof, Reichshof Eckenhagen
    Pneumologie 55:553-62. 2001
    ..P2 and P5) or a combination of both (P4 and P6) is useful, 69 patients (44 m/25 f) with moderate to severe COPD were randomised to a three week inpatient training program...
  20. ncbi Atrial natriuretic peptide (ANP) in chronic obstructive pulmonary disease (COPD): the relationship between plasma ANP and lung function. Effects of exercise and of the calcium antagonist, isradipine, on plasma ANP. A randomised, double-blind, placebo-cont
    N Graudal
    Department of Pulmonary Medicine P/Chest Clinic, Bispebjerg Hospital, Copenhagen, Denmark
    Horm Metab Res 24:130-3. 1992
    In patients with severe chronic obstructive pulmonary disease (COPD) an increased pulmonary arterial pressure (PAP), a raised plasma level of atrial natriuretic peptide (ANP) and a correlation between increasing PAP and increasing plasma ..
  21. ncbi [Incidence of cutaneous sensitization to environmental allergens in obstructive sleep apnea syndrome]
    H W Duchna
    Berufsgenossenschaftliche Kliniken Bergmannsheil, , Bochum
    Pneumologie 51:763-6. 1997
    ..skin test to at least one allergene was present in 49 per cent of the OSAS patients, compared to 14 per cent in COPD patients and 28 per cent in industrial workers (p < 0...
  22. ncbi Differences of disease characteristics between genders in emergency department elderly of a community hospital in Taiwan
    J C Chen
    Department of Emergency Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Chang Gung Med J 23:190-6. 2000
    ..05% vs. 5.45%, p < 0.001). Males presented most commonly with COPD (12.2%), compared to only 4.16% for females (p < 0...
  23. ncbi [Incidence of chronic obstructive respiratory tract disease in patients with obstructive sleep apnea]
    M Orth
    Berufsgenossenschaftliche Kliniken Bergmannsheil, Medizinische Klinik und Poliklinik, , Allergologie und Schlafmedizin, Bochum
    Pneumologie 50:286-9. 1996
    Data concerning the occurrence of chronic-obstructive pulmonary disease (COPD) in patients with obstructive sleep apnea syndrome (OSAS) vary between 11 and 20% due to the underlying definition of COPD...
  24. ncbi Effects of zolpidem and triazolam on sleep and respiration in mild to moderate chronic obstructive pulmonary disease
    R D Steens
    Sleep Research Laboratory, St. Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Canada
    Sleep 16:318-26. 1993
    ..and nocturnal arterial oxygen desaturation are common in patients with chronic obstructive pulmonary disease (COPD). Hence, the safety and efficacy of new hypnotic agents must be ascertained in this group of patients...
  25. ncbi Burden of chronic obstructive pulmonary disease in Medicare beneficiaries residing in long-term care facilities
    Linda Simoni-Wastila
    Peter Lamy Center on Drug Therapy and Aging, University of Maryland Baltimore School of Pharmacy, Baltimore, Maryland 21201, USA
    Am J Geriatr Pharmacother 7:262-70. 2009
    Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD increases health care resource utilization and spending and adversely affects quality of life...
  26. ncbi [The effect of chronic intermittent hypoxia caused by obstructive sleep apnea hypopnea syndrome on blood pressure]
    Li Mo
    Department of Respiratory Medicine, Peking University People s Hospital, Beijing, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:898-903. 2007
    ..intermittent hypoxia caused by obstructive sleep apnea hypopnea syndrome (OSAHS) and chronic continuous hypoxia caused by chronic obstructive pulmonary disease (COPD) on blood pressure and levels of nitric oxide (NO)/endothelin (ET).
  27. ncbi [Sensitivity and specificity of pulse oximetry in diagnosis of sleep-related respiratory disorders]
    H W Duchna
    BG-Krankenanstalten Bergmannsheil, ,
    Pneumologie 49:113-5. 1995
    ..97) to recognize sleep apnea-patients. Coincidence of COPD decreased specificity of pulse oxymetry from 0.48 to 0.23 but had no influence on its sensitivity...
  28. ncbi [Use of home mechanical ventilation in patients with high grade chronic obstructive lung disease (COPD)]
    B Schucher
    Krankenhaus Grosshansdorf, , Grosshansdorf
    Pneumologie 53:S103-6. 1999
    ..It has been introduced in acute respiratory failure in patients with COPD. The role of NIPPV in the long term treatment in severe stable hypercapnic COPD patients has not been well ..
  29. ncbi Cost reduction strategies used by elderly patients with chronic obstructive pulmonary disease to cope with a generic-only pharmacy benefit
    Michele M Spence
    Kaiser Permanente, 12254 Bellflower Blvd, Downey, CA 90242, USA
    J Manag Care Pharm 12:377-82. 2006
    Generic-only pharmacy benefits may present more of a burden to patients with chronic disease conditions such as chronic obstructive pulmonary disease (COPD), where generic drug therapy choices are more limited.
  30. ncbi [Intracutaneous tuberculin test using the Mendel-Mantoux technique. Tuberculin reactivity among inpatients in a pneumology department]
    A Elmer
    Pneumologische Abteilung, St. Hildegardis-Krankenhaus, Mainz
    Pneumologie 54:425-30. 2000
    ..7%) with a diagnosis different from tuberculosis (COPD, pneumonia, cancer and others)...
  31. ncbi [Fear of cortisone: in pulmonary rehabilitation it is less than expected. Results of a patient survey]
    A Hirschbichler
    , Klinik Bad Reichenhall der LVA Ndb.-Opf
    Pneumologie 54:68-71. 2000
    ..METHOD: Patients with COPD and asthma with inhalative and/or systemic corticoid medication received an extensive questionnaire during their ..
  32. ncbi [Ventilatory failure in COPD: follow-up under intermittent positive pressure ventilation (IPPV)]
    M Wiebel
    Abteilung Innere Medizin-Pneumologie, Thoraxklinik der LVA-Baden, Heidelberg Rohrbach
    Pneumologie 53:S100-2. 1999
    Effectiveness of IPPV in COPD is controversial. We examine the course of 29 patients with longterm IPPV (19 male, 10 female, age 60.3 years, BMI 23.7, FEV1 mean 22% predicted, PaCO2 mean 67 mmHg). PaCO2 is significantly by IPPV reduced...
  33. ncbi [Prevalence and difficulties in chronic obstructive pulmonary disease diagnosis in patients suffering from severe peripheral arterial disease]
    Justyna Sleszycka
    Medical University of Warsaw, Department and Clinic of Internal Medicine, Pulmonology and Allergology, Poland
    Pol Merkur Lekarski 27:92-6. 2009
    Cigarette smoking is the most prominent risk factor for chronic obstructive pulmonary disease (COPD) and peripheral arterial disease (PAD). Prevalence of COPD among cigarette smokers is about 23% in Poland...
  34. ncbi The use of plethysmography and oscillometry to compare long-acting bronchodilators in patients with COPD
    Zoe L Borrill
    Medicines Evaluation Unit, North West Lung Centre, University of Manchester, South Manchester University Hospitals NHS Trust, Manchester, UK
    Br J Clin Pharmacol 65:244-52. 2008
    ..in 1 s (FEV(1)) is the standard measurement used to measure drug effects in chronic obstructive pulmonary disease (COPD) clinical trials...
  35. ncbi A patient-based system for describing ambulatory medicine practices using diagnosis clusters
    B C Williams
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville
    J Gen Intern Med 6:57-63. 1991
    ..g., hypertension, dementia, COPD)...
  36. ncbi Chronic obstructive pulmonary disease and sleep apnea syndrome
    E Weitzenblum
    Department of Pulmonology, , France
    Sleep 15:S33-5. 1992
    ..by Flenley to describe the association of sleep apnea syndrome (SAS) with chronic obstructive pulmonary disease (COPD)...
  37. ncbi Chronic obstructive pulmonary disease surveillance--United States, 1971-2000
    David M Mannino
    Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop E 17, Atlanta, GA 30333, USA
    Respir Care 47:1184-99. 2002
    Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema but has been defined recently as the physiologic finding of nonreversible pulmonary function impairment...
  38. ncbi Economic burden in direct costs of concomitant chronic obstructive pulmonary disease and asthma in a Medicare Advantage population
    Christopher M Blanchette
    Center for Pharmacoeconomic and Outcomes Research, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 5127, USA
    J Manag Care Pharm 14:176-85. 2008
    Chronic obstructive pulmonary disease (COPD) is a highly prevalent disease whose sufferers consume a large amount of resources. Among community-dwelling Medicare beneficiaries, 12% reported that they had COPD in 2002...
  39. ncbi [Fitness training during nasal ventilation in diseases limited by dyspnea]
    M J Schmidt
    , Medizinische Klinik, Abteilungen Pneumologie, Beatmungsmedizin und Schlaflabor, Bovenden-Lenglern
    Pneumologie 53:S109-12. 1999
    ..Three of them suffered from severe COPD (FEV1 < 50%), two patients from severe restriction (VC < 30%)...
  40. ncbi Guideline for the management of chronic obstructive pulmonary disease (COPD): 2004 revision
    E D Bateman
    University of Cape Town Lung Institute
    S Afr Med J 94:559-75. 2004
    To revise the South African Guideline for the Management of Chronic Obstructive Pulmonary Disease (COPD) in the light of new insights into the disease and the value of new treatment approaches and drugs...
  41. ncbi Thymostimulin administration modulates polymorph metabolic pathway in patients with chronic obstructive pulmonary disease
    C Tortorella
    University of Bari Medical Faculty, Policlinico, Italy
    Immunopharmacol Immunotoxicol 14:421-37. 1992
    Several studies outline the imbalance of phagocyte functions in chronic obstructive pulmonary disease (COPD)...
  42. ncbi Neuropsychological function in obstructive sleep apnea syndrome (OSAS) compared to chronic obstructive pulmonary disease (COPD)
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202, USA
    Sleep 18:382-8. 1995
    Forty-nine men, 25 with obstructive sleep apnea syndrome (OSAS) and 24 with chronic obstructive pulmonary disease (COPD), were evaluated with a standard 8-hour nocturnal polysomnogram, multiple sleep latency test the following day and a ..
  43. ncbi hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease
    Shi fang Yang
    Department of Respiratory Medicine, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Chin Med J (Engl) 122:960-6. 2009
    ..cell apoptosis and death, which may be associated with the development of chronic obstructive pulmonary disease (COPD)...
  44. ncbi Inflammatory cells and chronic obstructive pulmonary disease
    Teresa D Tetley
    Lung Cell Biology, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Curr Drug Targets Inflamm Allergy 4:607-18. 2005
    A major contributory factor to the development of chronic obstructive pulmonary disease (COPD) is the inflammatory response to cigarette smoke...
  45. ncbi [The effects of recombinant human tumor necrosis factor-Fc on pulmonary function in a rat model of chronic obstructive pulmonary disease]
    Cheng Zhang
    Department of Respiratory Medicine, Xiangya Second Hospital of Central South University, Changsha 410011, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:432-6. 2007
    To investigate the influence of recombinant human tumor necrosis factor-Fc (rhTNFR: Fc) on pulmonary function in a rat model of chronic obstructive pulmonary disease (COPD).
  46. ncbi [Physical therapy in patients with COPD and tracheobronchial instability--comparison of 2 oscillating PEP systems (RC-Cornet, VRP1 Desitin). Results of a randommized prospective study of 90 patients]
    U H Cegla
    Hufeland-Klinik, , Bad Erns
    Pneumologie 51:129-36. 1997
    ..Regarding cough the significance was just failed by p < 0.055. RC-Cornet is a comfortable, effective, small accepted tool for the long term physiotherapy of patients with COAD and tracheobronchial instability...
  47. ncbi Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD
    Susan J Keam
    Adis International Inc, Yardley, Pennsylvania, USA
    Treat Respir Med 3:247-68. 2004
    ..18 micrograms once daily than with placebo in 6-month and 1-year randomized, double-blind trials in patients with COPD. Tiotropium improved lung function (trough FEV(1) response) more effectively than ipratropium bromide (ipratropium) ..
  48. ncbi Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma
    K Spiropoulos
    Division of Pulmonology, Laboratory of Sleep, University of Patras Medical School, Patras 26 500, Greece
    Respir Med 97:983-9. 2003
    Endothelin-1 (ET-1) has been implicated in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD)...
  49. ncbi Stages of disease severity and factors that affect the health status of patients with chronic obstructive pulmonary disease
    T Hajiro
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Respir Med 94:841-6. 2000
    ..health status would differ in patients at different disease stages of chronic obstructive pulmonary disease (COPD)...
  50. ncbi [Psychosocial aspects of chronic respiratory tract diseases (COPD): relevance and consequences for pulmonary rehabilitation]
    U Kaiser
    Hochgebirgsklinik Davos-Wolfgang, Schweiz
    Pneumologie 51:120-8. 1997
    ..1 years) with COPD (mean duration = 16 years) and a high percentage of multimorbidity (75%)...
  51. ncbi [The function of nuclear factor-erythroid 2-related factor 2 and its association with I-kappa B kinases alpha/beta in a rat model of chronic obstructive pulmonary disease.]
    Xiu Ying Li
    Respiratory Department of Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:935-9. 2009
    To study the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the bronchial and lung tissues of chronic obstructive pulmonary disease (COPD) rat models and its association with I-kappa B kinases (IKKs).
  52. ncbi Contemporary management of chronic obstructive pulmonary disease: scientific review
    Don D Sin
    Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada
    JAMA 290:2301-12. 2003
    The care of patients with chronic obstructive pulmonary disease (COPD) has changed radically over the past 2 decades, and novel therapies can not only improve the health status of patients with COPD but also modify its natural course.
  53. ncbi Exacerbations of chronic obstructive pulmonary disease
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    Respir Care 48:1204-13; discussion 1213-5. 2003
    Exacerbations of chronic obstructive pulmonary disease (COPD) cause morbidity, hospital admissions, and mortality, and strongly influence health-related quality of life...
  54. ncbi [Dangerous complication of transtracheal oxygen therapy with the SCOOP(R) system]
    T B Rothe

    Pneumologie 50:700-2. 1996
    ..This report describes a 70 year old female with COPD that developed acute respiratory distress 18 days after inserting PRESCOOP(R) and 11 days after changing to SCOOP 1 ..
  55. ncbi Risk of hospitalizations/emergency department visits and treatment costs associated with initial maintenance therapy using fluticasone propionate 500 microg/salmeterol 50 microg compared with ipratropium for chronic obstructive pulmonary disease in older
    Christopher M Blanchette
    Center for Pharmacoeconomic and Outcomes Research, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Am J Geriatr Pharmacother 6:138-46. 2008
    Cost-effective treatments for chronic obstructive pulmonary disease (COPD) are needed to reduce the burden on the Medicare system.
  56. ncbi Economic burden of chronic obstructive pulmonary disease. Impact of new treatment options
    M Friedman
    Section of Pulmonary Disease, Critical Care Medicine, and Environmental Medicine, Tulane University Medical Center, School of Medicine, New Orleans, LA, USA
    Pharmacoeconomics 19:245-54. 2001
    The incidence, morbidity and mortality of chronic obstructive pulmonary disease (COPD) is rising throughout the world. The total economic cost of COPD in the US in 1993 was estimated to be over $US15.5 billion, with $US6...
  57. ncbi Tiotropium administered by a pressurized metered dose inhaler (pMDI) and spacer produces a similar bronchodilator response as that administered by a Rotahaler in adult subjects with stable moderate-to-severe COPD
    B Brashier
    Chest Research Foundation, Marigold Complex, Kalyaninagar, Pune 411014, India
    Respir Med 101:2464-71. 2007
    ..which is recommended as first-line therapy in the management of chronic obstructive pulmonary disease (COPD). It is currently available in the form of a dry powder inhaler worldwide...
  58. ncbi [Does COPD affect bone mineral content?]
    C Hens
    Karl Hansen Klinik, Bad Lippspringe
    Pneumologie 44:204-5. 1990
    In a retrospective study, 85 COPD patients not treated with steroids, and 78 who received steroid therapy, were compared with a control group of normal subjects (n = 126) matched for age and sex...
  59. ncbi A two-stage logistic model based on the measurement of pro-inflammatory cytokines in bronchial secretions for assessing bacterial, viral, and non-infectious origin of COPD exacerbations
    Roberto W Dal Negro
    Lung Department, Orlandi General Hospital, Bussolengo, Verona, Italy
    COPD 2:7-16. 2005
    Exacerbations often complicate the progressive course of chronic obstructive pulmonary disease (COPD), mainly due to infectious agents...
  60. ncbi China makes impressive achievements in COPD therapy
    X Li
    Shandong University, Ji Nan, P R China
    Biosci Trends 2:94-5. 2008
    Chronic obstructive pulmonary disease (COPD), a common and frequently occurring lung ailment characterized by obstruction of airflow that interferes with normal breathing, is an overall term for life threatening lung diseases that ..
  61. ncbi [Self assessment quality of life and lung diseases (SAQOL in patients with pulmonary carcinoma: influence to survival and impact of chronic obstructive pulmonary disease]
    P R Grahmann
    Pneumologie und Allergologie Immunologie, Friedrich Schiller Universitat, Jena
    Pneumologie 59:446-55. 2005
    Lung cancer and chronic obstructive pulmonary disease (COPD) often occur concomitantly...
  62. ncbi Comparison of levalbuterol and racemic albuterol in hospitalized patients with acute asthma or COPD: a 2-week, multicenter, randomized, open-label study
    James F Donohue
    School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7020, USA
    Clin Ther 30:989-1002. 2008
    ..be administered every 1 to 4 hours for treating patients with asthma or chronic obstructive pulmonary disease (COPD) in the hospital...
  63. ncbi Nutritional support and quality of life in stable chronic obstructive pulmonary disease (COPD) patients
    Merce Planas
    Hospital Universitario Vall d Hebron, Barcelona, Spain
    Clin Nutr 24:433-41. 2005
    Nutritional depletion is a common problem in chronic obstructive pulmonary disease (COPD) patients. It is caused, to a large extent, by an imbalance between low-energy intake and high-energy requirements...
  64. ncbi Comparison of hospitalizations, emergency department visits, and costs in a historical cohort of Texas Medicaid patients with chronic obstructive pulmonary disease, by initial medication regimen
    Karen L Rascati
    College of Pharmacy and the Center for Pharmacoeconomic Studies, University of Texas at Austin, Austin, Texas 78712 0127, USA
    Clin Ther 29:1203-13. 2007
    Limited information is available on the relative outcomes and treatment costs of various pharmacotherapies for chronic obstructive pulmonary disease (COPD) in a Medicaid population.
  65. ncbi Color Doppler evaluation of the ocular arterial flow changes in chronic obstructive pulmonary disease
    Tulay Ozer
    Department of Radiology, Karaelmas University, School of Medicine, Tip Fakultesi, Radyoloji AD, Kozlu, Zonguldak, Turkey
    Eur J Radiol 57:63-8. 2006
    ..hemodynamic changes in the extraocular orbital vessels of the patients with chronic obstructive pulmonary disease (COPD), using color Doppler ultrasonography (CDU) technique, and to compare the results with those of healthy control ..
  66. ncbi Contemporary issues in the care of patients with chronic obstructive pulmonary disease
    Frank L Urbano
    Mount Laurel Primary Care Physicians, PC, 1000 Birchfield Dr, Suite 1004, Mount Laurel, NJ 08054, USA
    J Manag Care Pharm 11:S2-13; quiz S14-6. 2005
    Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and is estimated to be responsible for 119,000 deaths in the year 2000 alone...
  67. ncbi Caregiver-assisted coping skills training for patients with COPD: background, design, and methodological issues for the INSPIRE-II study
    James A Blumenthal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Clin Trials 6:172-84. 2009
    Chronic Obstructive Pulmonary Disease (COPD) is a progressive illness characterized by airflow obstruction and dyspnea that afflicts over 12 million people and represents a leading cause of death in the United States...
  68. ncbi [Effect of intermittent ventilation on pulmonary hypertension in chronic respiratory failure]
    B Schonhofer
    Krankenhaus Kloster Grafschaft, Zentrum fur Pneumologie, Beatmungs und Schlafmedizin, Schmallenberg Grafschaft
    Pneumologie 53:S113-5. 1999
    ..8 +/- 7.6 mmHg) and 13 patients with COPD (n = 13, PaCO2: 58.5 +/- 7.8 mmHg). All patients were mechanically ventilated in controlled mode...
  69. ncbi [Effect duration and treatment effectiveness of salmeterol, fenoterol and salbutamol in severe forms of respiratory tract obstruction]
    M Vollmer
    Berufsgenossenschaftliche Kliniken Bergmannsheil,
    Pneumologie 49:528-34. 1995
    ..2 mg Fenoterol, 0.2 mg Salbutamol, and 0.05 mg Salmeterol were investigated in 15 subjects with COPD over a period of 12 hours. Airway resistance and FEV1 were measured and subjective side effects noted...
  70. ncbi [Expression and significance of beta(2)-adrenoreceptor in inflammatory cells of patients with chronic obstructive pulmonary disease]
    Wei Jing Zhu
    Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 88:2099-102. 2008
    To investigate the relationship between beta(2)-adrenoceptor (beta(2)-AR) expression in inflammatory cells and airflow limitation in patients with chronic obstructive pulmonary disease (COPD).
  71. ncbi Vascular endothelial growth factor: an angiogenic factor reflecting airway inflammation in healthy smokers and in patients with bronchitis type of chronic obstructive pulmonary disease?
    Nikoletta Rovina
    Asthma and Allergy Center, Pulmonary and Critical Care Department, Evgenidion Hospital, Medical School, University of Athens, Greece
    Respir Res 8:53. 2007
    Patients with bronchitis type of chronic obstructive pulmonary disease (COPD) have raised vascular endothelial growth factor (VEGF) levels in induced sputum...
  72. ncbi [Limitations of noninvasive mask ventilation in acute hypoxemic gas exchange disorders (COPD)]
    O Karg
    ,
    Pneumologie 53:S95-7. 1999
    ..NIMV) compared to mechanical ventilation after intubation is proven in patients with acute exacerbation of COPD. Contrary to this point the benefit is not clear in patients with acute gas exchange failure, such as in pneumonias...
  73. ncbi Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management
    Joan Albert Barbera
    Department of Pulmonary Medicine, Hospital Clinic, Universitat de Barcelona, Spain
    Drugs 69:1153-71. 2009
    ..hypertension (PH) is an important complication in the natural history of chronic obstructive pulmonary disease (COPD). Its presence is associated with reduced survival and greater use of healthcare resources...
  74. ncbi Prevalence of chronic obstructive pulmonary disease in blacks
    K M Bang
    Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville, Maryland 20782
    J Natl Med Assoc 85:51-5. 1993
    Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and mortality in blacks...
  75. ncbi Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial
    Rudolf A Baumgartner
    Sepracor Inc, Marlborough, Massachusetts 01752, USA
    Clin Ther 29:261-78. 2007
    ..of nebulized arformoterol tartrate (a selective, long-acting beta(2)-adrenergic agonist that is the [R,R] isomer of formoterol) and salmeterol xinafoate versus placebo in patients with chronic obstructive pulmonary disease (COPD).
  76. ncbi Chronic obstructive pulmonary disease: less common causes--an algorithm for the primary care physician
    R C St John
    Department of Medicine, Ohio State University Hospitals, Columbus
    J Gen Intern Med 8:564-72. 1993
    ..of the patient with dyspnea and chronic airflow obstruction has been outlined, with the goal of identifying those patients with potentially reversible disease, and to underscore the fact that not all "COPD" is due to cigarette smoking.
  77. ncbi Usefulness of the modified 0-10 Borg scale in assessing the degree of dyspnea in patients with COPD and asthma
    K R Kendrick
    Emergency Department and Urgent Care Clinic, Veterans Administration San Diego Healthcare System, San Diego, Calif
    J Emerg Nurs 26:216-22. 2000
    ..posttreatment assessment notes on patients with exacerbations of asthma or chronic obstructive pulmonary disease (COPD) who were seen in the emergency department and urgent care clinic...
  78. ncbi Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study
    Robert Vassallo
    The Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Department of Internal Medicine, the Clinical Immunology and Immunotherapeutics Program, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
    Respir Res 11:45. 2010
    ..immune responses are believed to be highly relevant in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dendritic cells provide a critical checkpoint for immunity by their capacity to both induce and suppress immunity...
  79. ncbi Biomass fuels are the probable risk factor for chronic obstructive pulmonary disease in rural South China
    Shengming Liu
    Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical College, 195 Dongfeng Xi Road, Guangzhou 510182, P R China
    Thorax 62:889-97. 2007
    There is increasing evidence for a possible association between chronic obstructive pulmonary disease (COPD) and the use of biomass fuels for cooking and heating in developing countries...
  80. ncbi [Association of tumor necrosis factor alpha 308 G/A gene promoter polymorphism with the presence of chronic obstructive pulmonary disease: a meta-analysis]
    Guo ping Hu
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:588-94. 2007
    To investigate the association between the polymorphism of tumor necrosis factor alpha 308 gene (TNF-alpha-308) promoter and the risk of chronic obstructive pulmonary disease (COPD) using the method of meta-analysis.
  81. ncbi [Euphylong in standard dosage: comparison with an international retard preparation for twice-daily administration in recommended dosage]
    G Siemon
    Krankenhaus Donaustauf, LVA Niederbayern-Oberpfalz
    Pneumologie 45:853-7. 1991
    24 patients with COPD and delta FEV1 greater than 15% were included in a double-blind crossover study. 7 dropouts due to deterioration of findings and incomplete data reduced the number of assessable patients to 17...
  82. ncbi Impact of COPD on outcome among patients with complicated peptic ulcer
    Steffen Christensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark
    Chest 133:1360-6. 2008
    b>COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term mortality among patients with bleeding and a perforated peptic ulcer...
  83. ncbi Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing
    Ling Jiang
    Department of Pulmonary Disease, Peking University Third Hospital, Beijing 100083, China
    Chin Med J (Engl) 118:541-7. 2005
    ..factors are believed to play a role in the individual susceptibility to chronic obstructive pulmonary disease (COPD)...
  84. ncbi Effect of cigarette smoke on the permeability and IL-1beta and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease
    C Rusznak
    Academic Department of Respiratory Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, The London Chest Hospital, London, United Kingdom
    Am J Respir Cell Mol Biol 23:530-6. 2000
    Although cigarette smoking is of paramount importance in the development of chronic obstructive pulmonary disease (COPD), only a small proportion of smokers develop the disease...
  85. ncbi Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy
    Matthew W Lawless
    Centre for Liver Disease, School of Medicine and Medical Science, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland
    J Cell Mol Med 13:2800-21. 2009
    ....
  86. ncbi Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease
    Ganapathi I Parameswaran
    Division of Infectious Diseases, University at Buffalo, State University of New York, 701 Ellicott Street, Buffalo, NY 14203, USA
    BMC Infect Dis 9:178. 2009
    Moraxella catarrhalis causes approximately 10% of exacerbations in chronic obstructive pulmonary disease (COPD) and also colonizes the lower airway in stable patients. Little is known about the effects of colonization by M...
  87. ncbi [Serum theophylline concentrations in patients with chronic obstructive lung diseases: a comparison of 2 methods]
    T Voshaar
    Innere Abteilung und Zentrallaboratorium des Marienhospitals, Gelsenkirchen
    Pneumologie 44:283-4. 1990
    A total of 120 samples of serum were obtained from 8 patients with COPD and submitted to a comparative analysis of serum theophylline levels employing the TDX and the EMIT methods of determination...
  88. ncbi Systemic and bronchodilator effects of inhaled rac-formoterol in subjects with chronic obstructive pulmonary disease: a dose-response study
    Christopher I Whale
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham, UK
    Br J Clin Pharmacol 65:841-7. 2008
    ..as relief medication in asthma and there is interest in this approach in chronic obstructive pulmonary disease (COPD)...
  89. ncbi Relationship between polymorphisms of genes encoding microsomal epoxide hydrolase and glutathione S-transferase P1 and chronic obstructive pulmonary disease
    Dan Xiao
    Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    Chin Med J (Engl) 117:661-7. 2004
    Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). However, only 10% - 20% of chronic heavy cigarette smokers develop symptomatic disease...
  90. ncbi Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD
    D L DeMeo
    Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thorax 59:396-400. 2004
    The Boston Early-Onset COPD study showed that current or ex-smoking first degree relatives of severe early onset COPD probands have significantly lower forced expiratory volume in 1 second (FEV(1)) and FEV(1)/forced vital capacity (FVC) ..
  91. ncbi Bronchial hyper-responsiveness and exhaled nitric oxide in chronic obstructive pulmonary disease
    Salome Schafroth Török
    Pulmonary Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 137:385-91. 2007
    Several lung diseases including asthma and chronic obstructive pulmonary disease (COPD) involve chronic inflammation of the airways. Therefore, there is great interest in non-invasive methods assessing airway inflammation...
  92. ncbi A 1-year prospective cost-effectiveness analysis of roflumilast for the treatment of patients with severe chronic obstructive pulmonary disease
    Maureen P M H Rutten-van Mölken
    Institute for Medical Technology Assessment, Erasmus MC, Rotterdam, The Netherlands
    Pharmacoeconomics 25:695-711. 2007
    ..once-daily phosphodiesterase IV (PDE4) inhibitor under investigation for chronic obstructive pulmonary disease (COPD)...
  93. ncbi Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats
    Shan Cai
    Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China
    Respirology 14:354-9. 2009
    The role of apoptosis in lung destruction in emphysema/COPD is increasingly being recognized. The relationship between anti-oxidants and alveolar septal cell apoptosis in COPD lungs remains to be elucidated...
  94. ncbi Plasma lipoproteins in chronic obstructive pulmonary disease
    T Fekete
    Second Medical Clinic, Medical Institute, Cluj-Napoca, Romania
    Horm Metab Res 19:661-2. 1987
    Plasma lipoprotein fractions have been assessed in 29 patients with chronic obstructive pulmonary disease (COPD), and compared with non-COPD subjects...
  95. ncbi [Minimally invasive surgery of large bullous pulmonary emphysema]
    A Linder
    , Zentrum f. Pneumologie und Thoraxchirurgie, Gerlingen
    Pneumologie 49:236-8. 1995
    ..The symptoms did not improve under conservative therapy of an accompanying COPD. Thus, in spite of two heart attacks in the previous history, an operation with bullectomy was indicated...
  96. ncbi [Course of pulmonary hemodynamics in intermittent ventilation]
    F Herth
    Thoraxklinik, Abteilung Pneumonologie Heidelberg
    Pneumologie 53:S120-1. 1999
    ..The data show that ISB lowers the pressure in all patients, more in patients with restrictive diseases, due to thoracic deformities, than in patients with COPD.
  97. ncbi [Physical performance in home ventilation patients]
    B Kroworsch
    ,
    Pneumologie 53:S107-8. 1999
    ..3 other patients ventilated for more than one year who underwent an additional physical training programme as in COPD patients for rehabilitation...
  98. ncbi [RC-Cornet(R) improves the bronchodilating effect of Ipratropiumbromide (Atrovent(R)) inhalation in COPD-patients]
    U H Cegla
    Pneumologisches Forschungsinstitut am Herz-Jesu-Krankenhaus Dernbach
    Pneumologie 55:465-9. 2001
    In 35 patients with severe COPD and tracheal-bronchial instability the bronchodilatory effect of salbutamol (Salbulair(R) Autohaler) was tested prospectively, randomized and crossover on two consecutive days by bodyplethysmography...
  99. ncbi [The education program for patients with COPD from Bad Reichenhall]
    S Spohn
    ,
    Pneumologie 55:470-4. 2001
    An education program for patients with COPD is presented. This program was created for inpatient pulmonary rehabilitation at the Klinik Bad Reichenhall...
  100. ncbi Utility of pulmonary function testing in the management of chronic obstructive pulmonary disease
    J E Casanova
    Department of Medicine, Medical College of Wisconsin, Milwaukee
    J Gen Intern Med 8:448-50. 1993
    ..data on the decisions made by generalist physicians in the management of chronic obstructive pulmonary disease (COPD)...
  101. ncbi [Responder and non-responder in the bronchodilator test?]
    M Vollmer
    Abteilung für Pneumologie und Allergologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Universitätsklinik Bochum
    Pneumologie 49:584-9. 1995
    ..that tests of acute reversibility of airways obstruction cannot reliably differentiate between "responders" and "non-responders" and that such tests may mislead if used for the differentiation of asthma and COPD.

Research Grants79

  1. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
    ..Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with goblet cell hyperplasia, irreversible airway obstruction, chronic ..
  2. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with goblet cell hyperplasia, irreversible airway obstruction, chronic ..
  3. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2010
    Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of chronic morbidity and mortality in the United States...
  4. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2009
    Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of chronic morbidity and mortality in the United States...
  5. COPD Clinical Research Network
    Frank Sciurba; Fiscal Year: 2007
    ..S. Factors, which have impaired effective research in COPD, include misconceptions that the disease is irreversible and untreatable and a lack of consensus on optimal ..
  6. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    Chronic obstructive pulmonary disease (COPD) morbidity and mortality are rising, a trend that is unique among the top five causes of death in the USA...
  7. Depression and functional outcomes in COPD: Impact of genetics and inflammation
    HUONG Q contact NGUYEN; Fiscal Year: 2010
    Depression is highly prevalent among patients with chronic obstructive pulmonary disease (COPD) and is associated with adverse clinical outcomes...
  8. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2009
    ..neutrophil (PMN) influx and damage to the airways that may play a role in chronic obstructive pulmonary disease (COPD)...
  9. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
    ..neutrophil (PMN) influx and damage to the airways that may play a role in chronic obstructive pulmonary disease (COPD)...
  10. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2007
    ..neutrophil (PMN) influx and damage to the airways that may play a role in chronic obstructive pulmonary disease (COPD)...
  11. Quantitative Structural and Functional Imaging of the Lung
    Rahim R Rizi; Fiscal Year: 2010
    Chronic Obstructive Pulmonary Disease (COPD), a group of disorders characterized by limitations in airflow, affects over 14 million Americans and is the fourth leading cause of death in the United States...
  12. Metabolome and proteome profiles of emphysema and airway disease
    RUSSELL PAUL BOWLER; Fiscal Year: 2010
    Chronic obstructive pulmonary disease (COPD) is the most common lung disease in the world, yet little is known about why only 20% of smokers are susceptible to developing the disease...
  13. Metabolome and proteome profiles of emphysema and airway disease
    Russell Bowler; Fiscal Year: 2009
    Chronic obstructive pulmonary disease (COPD) is the most common lung disease in the world, yet little is known about why only 20% of smokers are susceptible to developing the disease...
  14. Pathogenesis of Haemophilus influenzae infection in COPD
    Timothy F Murphy; Fiscal Year: 2010
    Chronic obstructive pulmonary disease (COPD) is a debilitating disease and is the fourth most common cause of death in the US...
  15. Linking airway genomics to the pathogenesis and clinical heterogeneity of COPD
    AVRUM E contact SPIRA; Fiscal Year: 2010
    Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and its mortality rate is expected to climb steadily over the next 20 years...
  16. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide and is increasing with a high prevalence, high morbidity and high cost...
  17. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..can be used to mitigate, and remediate, alveolar loss in individuals with chronic obstructive pulmonary disease (COPD)...
  18. Translating COPD Guidelines inot Primary Care Practice
    Donna R Parker; Fiscal Year: 2010
    ..Gold (the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease) COPD guidelines into primary care practice...
  19. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ contact ENGELEN; Fiscal Year: 2010
    Chronic Obstructive Pulmonary Disease (COPD) is considered a systemic disease that involves pathology in several extra pulmonary tissues...
  20. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip Boiselle; Fiscal Year: 2009
    ..the prevalence and natural history of tracheomalacia among patients with chronic obstructive pulmonary disease (COPD) and to establish the role of a novel CT method in guiding therapy and assessing response to intervention...
  21. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip M Boiselle; Fiscal Year: 2010
    ..the prevalence and natural history of tracheomalacia among patients with chronic obstructive pulmonary disease (COPD) and to establish the role of a novel CT method in guiding therapy and assessing response to intervention...
  22. Role of Squamous Metaplasia in Small Airways Disease in COPD
    Stephen L Nishimura; Fiscal Year: 2010
    Chronic Obstructive Pulmonary Disease (COPD) is caused by loss of the walls of air sacs and by narrowing of the airways due to scarring. Currently, there are no effective therapies to treat COPD...
  23. Pathogenesis of Haemophilus influenzae infection in COPD
    Timothy Murphy; Fiscal Year: 2009
    Chronic obstructive pulmonary disease (COPD) is a debilitating disease and is the fourth most common cause of death in the US...
  24. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2007
    ..and infection of interluminal mucus that contribute to the pathogenesis of airways disease in cystic fibrosis and COPD. The SCCOR proposes six Projects to test this hypothesis: Project I: The Mucus Transport Apparatus: Why Two Layers? ..
  25. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2010
    Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. COPD will overtake stroke as the third leading cause of death within 7 years...
  26. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2010
    DESCRIPTION (provided by investigator): COPD and pneumonia are among the leading causes of morbidity and mortality in adults 60 years and older, and pneumonia rates are higher for those with COPD...
  27. Disarray of Injury/Regeneration Homeostasis in Smoking-Induced COPD
    Ronald Crystal; Fiscal Year: 2007
    Chronic obstructive lung disease (COPD), a leading cause of pulmonary disability and death, is caused mainly by cigarette smoking...
  28. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2007
    Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the United States...
  29. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2010
    ..that may play a role as an initiator or cofactor for chronic lung diseases such as obstructive pulmonary disease (COPD), cystic fibrosis (CF), and chronic lung transplant rejection...