Gene Symbol: AQP5
Description: aquaporin 5
Alias: AQP-5, PPKB, aquaporin-5
Species: human
Products:     AQP5

Top Publications

  1. Ma T, Yang B, Umenishi F, Verkman A. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Genomics. 1997;43:387-9 pubmed
    ..human aquaporins cloned to date (AQPs 0-6), genes encoding the four most closely related aquaporins (AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus...
  2. Chae Y, Woo J, Kim M, Kang S, Kim M, Lee J, et al. Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS ONE. 2008;3:e2162 pubmed publisher
    ..Here, by immunohistochemistry (IHC), we have found an expression of AQP5 protein in 35.3% (IHC-score: > or = 1, 144/408) of the resected NSCLC tissue samples...
  3. Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, et al. Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci. 2009;59:113-22 pubmed publisher
    ..In the upper or middle part of human stomach, we found that expression level of AQP5 protein in intestinal type of adenocarcinoma was significantly higher than that in accompanying normal mucosa...
  4. Ning Y, Ying B, Han S, Wang B, Wang X, Wen F. Polymorphisms of aquaporin5 gene in chronic obstructive pulmonary disease in a Chinese population. Swiss Med Wkly. 2008;138:573-8 pubmed publisher
    ..We designed denaturing high performance liquid chromatography (DHPLC) to detect SNP in exons1, 2, 3 of AQP5 and DNA sequencing to confirm it...
  5. Gresz V, Kwon T, Hurley P, Varga G, Zelles T, Nielsen S, et al. Identification and localization of aquaporin water channels in human salivary glands. Am J Physiol Gastrointest Liver Physiol. 2001;281:G247-54 pubmed
    ..Expression of aquaporin mRNA was assessed by RT-PCR using specific primers for human AQP1, AQP3, AQP4, and AQP5. All four aquaporins were detected by RT-PCR in all of the glands, and the sequences were confirmed after further ..
  6. Ben Y, Chen J, Zhu R, Gao L, Bai C. Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells. Respir Physiol Neurobiol. 2008;161:111-8 pubmed publisher
    ..AQP1 and AQP5 expressed in lung provide the principal route for osmotically driven water transport...
  7. Woo J, Chae Y, Jang S, Kim M, Baek J, Park J, et al. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun. 2008;366:321-7 pubmed
    Phosphorylation pathway has been identified as an important step in membrane trafficking for AQP5. We generated stably transfected BEAS-2B human bronchial epithelial cells with various over-expression constructs on permeable support...
  8. Wang K, Feng Y, Wen F, Chen X, Ou X, Xu D, et al. Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease. Acta Pharmacol Sin. 2007;28:1166-74 pubmed
    To investigate the relationship between aquaporin-5 (AQP5) expression and mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease (COPD) and the correlation with pulmonary function change...
  9. Sidhaye V, Schweitzer K, Caterina M, Shimoda L, King L. Shear stress regulates aquaporin-5 and airway epithelial barrier function. Proc Natl Acad Sci U S A. 2008;105:3345-50 pubmed publisher
    ..These changes lead to a selective decrease in aquaporin-5 (AQP5) abundance because of protein internalization and degradation...

More Information


  1. Chae Y, Kang S, Kim M, Woo J, Lee J, Chang S, et al. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS ONE. 2008;3:e2594 pubmed publisher
    ..Here, we report the expression of AQP5 in CML cells by RT-PCR and immunohistochemistry...
  2. Horsefield R, Nordén K, Fellert M, Backmark A, Törnroth Horsefield S, Terwisscha van Scheltinga A, et al. High-resolution x-ray structure of human aquaporin 5. Proc Natl Acad Sci U S A. 2008;105:13327-32 pubmed publisher
    Human aquaporin 5 (HsAQP5) facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the ..
  3. Shen L, Zhu Z, Huang Y, Shu Y, Sun M, Xu H, et al. Expression profile of multiple aquaporins in human gastric carcinoma and its clinical significance. Biomed Pharmacother. 2010;64:313-8 pubmed publisher
    ..AQP3 and AQP5 were detected remarkably stronger in the carcinoma tissues than that in normal mucosa by immunofluorescence...
  4. Shen Y, Chen Z, Wang Y, Song Z, Zhang Z, Jin M, et al. Aquaporin 5 expression inhibited by LPS via p38/JNK signaling pathways in SPC-A1 cells. Respir Physiol Neurobiol. 2010;171:212-7 pubmed publisher
    ..Recent studies suggest that decreased aquaporin 5 (AQP5) is correlated with increased staining of MUC5AC in submucosal glands of COPD patients...
  5. Shankardas J, Patil R, Vishwanatha J. Effect of down-regulation of aquaporins in human corneal endothelial and epithelial cell lines. Mol Vis. 2010;16:1538-48 pubmed
    The purpose of this study was to determine the effects of down-regulation of Aquaporin 1 (AQP1) and Aquaporin 5 (AQP5) on cell proliferation and migration in human corneal endothelial (HCEC) and human corneal epithelial (CEPI17) cell ..
  6. Yamamura Y, Motegi K, Kani K, Takano H, Momota Y, Aota K, et al. TNF-? inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation. J Cell Mol Med. 2012;16:1766-75 pubmed publisher
    ..human salivary gland acinar (NS-SV-AC) cells were treated with TNF-?, and then the expression levels of AQP5 mRNA and protein were analysed...
  7. Sekine S, Shimada Y, Nagata T, Moriyama M, Omura T, Watanabe T, et al. Prognostic significance of aquaporins in human biliary tract carcinoma. Oncol Rep. 2012;27:1741-7 pubmed publisher
    ..033, 0.002). In conclusion, the results of this study suggest that AQP-5 expression may be associated with prognosis and drug sensitivity in biliary tract carcinoma. ..
  8. Huang Y, Zhou X, Wang H, Xu H, Chen J, Lv N. Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumour Biol. 2013;34:1743-51 pubmed publisher
    b>Aquaporin 5 (AQP5) promotes the progression and invasion of several cancers, but its role in the tumorigenesis of human gastric carcinoma (GC) has not been clearly defined...
  9. Blaydon D, Lind L, Plagnol V, Linton K, Smith F, Wilson N, et al. Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet. 2013;93:330-5 pubmed publisher
    ..After exome sequencing, missense mutations were identified in AQP5, encoding water-channel protein aquaporin-5 (AQP5)...
  10. Lee M, Bhakta K, Raina S, Yonescu R, Griffin C, Copeland N, et al. The human Aquaporin-5 gene. Molecular characterization and chromosomal localization. J Biol Chem. 1996;271:8599-604 pubmed
    The cDNA for the fifth mammalian aquaporin (AQP5) was isolated from rat, and expression was demonstrated in rat salivary and lacrimal glands, cornea, and lung (Raina, S., Preston, G. M., Guggino, W. B., and Agre, P. (1995) J. Biol. Chem...
  11. Zhang Z, Zhu Z, Bai C, Chen Z. Aquaporin 5 expression increases mucin production in lung adenocarcinoma. Oncol Rep. 2011;25:1645-50 pubmed publisher
    Our recent studies have demonstrated that AQP5 is involved in the metastatic potential of lung cancer. Here, our aim was to explore the effects of AQP5 expression on mucin production in lung adenocarcinoma...
  12. Iizuka T, Suzuki T, Nakano K, Sueki H. Immunolocalization of aquaporin-5 in normal human skin and hypohidrotic skin diseases. J Dermatol. 2012;39:344-9 pubmed publisher
    ..AQP-5 was mostly localized to the plasma membranes of clear cells in the secretory coils of eccrine sweat glands, suggesting that it plays a role in producing the primary sweat fluid. ..
  13. Kang S, Chae Y, Woo J, Kim M, Park J, Lee J, et al. Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol. 2008;173:518-25 pubmed publisher
    ..Here, by immunochemistry, we have found expression of AQP5 protein in 62...
  14. Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M, et al. Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. Int J Oncol. 2012;41:67-75 pubmed publisher
    ..Recent studies have reported the expression of AQP5 in several tumor types such as gastric, pulmonary, ovarian, pancreatic and colorectal cancer...
  15. Garfias Y, Navas A, Perez Cano H, Quevedo J, Villalvazo L, Zenteno J. Comparative expression analysis of aquaporin-5 (AQP5) in keratoconic and healthy corneas. Mol Vis. 2008;14:756-61 pubmed
    ..Recently, the absence of transcripts of the water channel, aquaporin-5 (AQP5), was demonstrated by reverse-transcription polymerase chain reaction (RT-PCR) in KC tissues and was proposed as a ..
  16. Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, et al. Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci. 2013;70:26-33 pubmed publisher
    Aquaporin-5 (AQP5) is a member of the water channel protein family. Although AQP5 was shown to be present in sweat glands, the presence or absence of regulated intracellular translocation of AQP5 in sweat glands remained to be determined.
  17. Lee S, Chae Y, Kim J, Kim W, Jung J, Park H, et al. AQP5 expression predicts survival in patients with early breast cancer. Ann Surg Oncol. 2014;21:375-83 pubmed publisher
    Our previous study showed the association of aquaporin 5 (AQP5) up-regulation with cancer proliferation and migration in estrogen receptor (ER)-positive breast cancer cell line (MCF-7) and with unfavorable prognosis in a small number of ..
  18. Kamsteeg E, Heijnen I, Van Os C, Deen P. The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers. J Cell Biol. 2000;151:919-30 pubmed
  19. Kreda S, Gynn M, Fenstermacher D, Boucher R, Gabriel S. Expression and localization of epithelial aquaporins in the adult human lung. Am J Respir Cell Mol Biol. 2001;24:224-34 pubmed
    ..In nose and bronchial epithelia, AQP5 is expressed at the apical membrane of columnar cells of the superficial epithelium and submucosal gland acinar ..
  20. Nejsum L, Kwon T, Jensen U, Fumagalli O, Frøkiaer J, Krane C, et al. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci U S A. 2002;99:511-6 pubmed
    ..In this study, AQP1, AQP3, and AQP5 mRNA were demonstrated in rat paw by reverse transcription (RT)-PCR, but AQP2 and AQP4 were not...
  21. Sidhaye V, Guler A, Schweitzer K, D Alessio F, Caterina M, King L. Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Natl Acad Sci U S A. 2006;103:4747-52 pubmed
    Aquaporin-5 (AQP5) is expressed in epithelia of lung, cornea, and various secretory glands, sites where extracellular osmolality is known to fluctuate...
  22. Raina S, Preston G, Guggino W, Agre P. Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. J Biol Chem. 1995;270:1908-12 pubmed
    ..These studies have identified a new mammalian member of the Aquaporin water channel family (gene symbol AQP5) which is implicated in the generation of saliva, tears, and pulmonary secretions.
  23. Verkman A. Role of aquaporin water channels in eye function. Exp Eye Res. 2003;76:137-43 pubmed
    ..epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary epithelium and retinal Müller cells, and AQP5 in corneal and lacrimal gland epithelia...
  24. Burghardt B, Elkaer M, Kwon T, Racz G, Varga G, Steward M, et al. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut. 2003;52:1008-16 pubmed
    ..AQP3 and AQP4 were not detectable by immunohistochemistry. AQP5 was observed at the apical membrane of intercalated duct cells and also in duct associated mucoid glands...
  25. Chen Z, Zhang Z, Gu Y, Bai C. Impaired migration and cell volume regulation in aquaporin 5-deficient SPC-A1 cells. Respir Physiol Neurobiol. 2011;176:110-7 pubmed publisher
    b>Aquaporin 5 (AQP5) is widely expressed in various organ and tissues...
  26. Rodrigues C, Mósca A, Martins A, Nobre T, Prista C, Antunes F, et al. Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress. Int J Mol Sci. 2016;17: pubmed
    Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems...
  27. Chen S, Shan T, Wang L, Chen X, Cui X, Gao X. [Role of aquaporin-5 in regulating colorectal cancer cell growth in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1330-1336 pubmed
    To study the role of aquaporin 5(AQP5) in regulating the cell proliferation and apoptosis of human colorectal cancer cells and explore the possible mechanism...
  28. Tsunoda S, Wiesner B, Lorenz D, Rosenthal W, Pohl P. Aquaporin-1, nothing but a water channel. J Biol Chem. 2004;279:11364-7 pubmed
    ..The lack of significant CNG ion channel activity rules out a secondary role of AQP1 water channels in cellular signal transduction. ..
  29. Tsukaguchi H, Weremowicz S, Morton C, Hediger M. Functional and molecular characterization of the human neutral solute channel aquaporin-9. Am J Physiol. 1999;277:F685-96 pubmed
    ..1-22.2. Our data show that hAQP9 serves as a promiscuous solute channel expressed in both liver and peripheral leukocytes, where it is ideally suited to transport of metabolites and/or nutrients into and out of these cells ..
  30. Squillacioti C, De Luca A, Pero M, Vassalotti G, Lombardi P, Avallone L, et al. Effect of colostrum and milk on small intestine expression of AQP4 and AQP5 in newborn buffalo calves. Res Vet Sci. 2015;103:149-55 pubmed publisher
    ..Given that the physiological roles of AQP4 and AQP5 in the developing intestine have not been fully established, the objective of this investigation was to determine ..
  31. Direito I, Madeira A, Brito M, Soveral G. Aquaporin-5: from structure to function and dysfunction in cancer. Cell Mol Life Sci. 2016;73:1623-40 pubmed publisher
    ..In view of the wide range of cancer malignancies in which aquaporin-5 (AQP5) has been detected, an increasing interest in its implication in carcinogenesis has emerged...
  32. Smith J, Siddiqui A, Modica L, Dykes R, Simmons C, Schmidt J, et al. Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands. J Interferon Cytokine Res. 1999;19:929-35 pubmed
    ..Aquaporin-5 (AQP5) is uniquely present in lacrimal and salivary glands, where it accounts for normal tear and saliva production...
  33. Flodby P, Li C, Liu Y, Wang H, Rieger M, Minoo P, et al. Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017;7:3473 pubmed publisher
    ..358-bp promoter/enhancer (p358P/E) of lung alveolar epithelial type I (AT1) cell-specific gene aquaporin-5 (Aqp5)...
  34. Ono Minagi H, Sarper S, Kurosaka H, Kuremoto K, Taniuchi I, Sakai T, et al. Runx1 mediates the development of the granular convoluted tubules in the submandibular glands. PLoS ONE. 2017;12:e0184395 pubmed publisher
    ..Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane ..
  35. Jiang Y, Dai Z, Zhang X, Zhao W, Huang Q, Gao L. Dexmedetomidine alleviates pulmonary edema by upregulating AQP1 and AQP5 expression in rats with acute lung injury induced by lipopolysaccharide. J Huazhong Univ Sci Technolog Med Sci. 2015;35:684-688 pubmed publisher
    ..The mRNA and protein expression levels of aquaporin-1 (AQP1) and aquaporin-5 (AQP5) were detected by RT-PCR, immunohistochemistry, and Western blotting...
  36. Samuels T, Yan J, Khampang P, Dettmar P, Mackinnon A, Hong W, et al. Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion. JAMA Otolaryngol Head Neck Surg. 2017;143:810-817 pubmed publisher
    ..To investigate the association of gel-forming mucins and aquaporin 5 (AQP5) gene expression with inflammation, effusion viscosity, and hearing loss in pediatric OM with effusion (..
  37. Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, et al. Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5. Int J Oncol. 2017;50:1857-1867 pubmed publisher
    Previous studies described that the expression of aquaporin 5 (AQP5) was altered in tumors of various organs. AQP5 is attracting attention as a new cancer therapeutic target...
  38. Wu R, Dai M, Tian Z, Hu J, Zha L. Plasma level of soluble receptor for advanced glycation end-products and aquaporin 5 in preterm infants with acute respiratory distress syndrome. Minerva Pediatr. 2016;68:360-5 pubmed was to determine the plasma level of soluble receptors for advanced glycation end-products (sRAGE) and aquaporin 5 (AQP5) in preterm infants with acute respiratory distress syndrome (RDS)...
  39. Hahn A, Faulhaber J, Srisawang L, Stortz A, Salomon J, Mall M, et al. Cellular distribution and function of ion channels involved in transport processes in rat tracheal epithelium. Physiol Rep. 2017;5: pubmed publisher
    ..regulator (CFTR) Cl- channel, the epithelial Na+ channel ENaC, and the water channel aquaporin 5 (AQP5) in rat tracheal epithelium...
  40. Pires Neto R, Del Carlo Bernardi F, Alves de Araujo P, Mauad T, Dolhnikoff M. The Expression of Water and Ion Channels in Diffuse Alveolar Damage Is Not Dependent on DAD Etiology. PLoS ONE. 2016;11:e0166184 pubmed publisher
    ..We quantified the expression of aquaporin (AQP) 1, AQP3, AQP5, epithelial Na+ channel (ENaC) and sodium potassium ATPase (Na-K-ATPase) in the alveolar septum using ..
  41. Amann B, Kleinwort K, Hirmer S, Sekundo W, Kremmer E, Hauck S, et al. Expression and Distribution Pattern of Aquaporin 4, 5 and 11 in Retinas of 15 Different Species. Int J Mol Sci. 2016;17: pubmed publisher
    ..AQP4 was detected in all 15 explored species, AQP5 and AQP11 in 14 out of 15...
  42. Pedersen P, Braunstein T, Jørgensen A, Larsen P, Holstein Rathlou N, Frederiksen O. Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress. Pflugers Arch. 2007;453:777-85 pubmed
    ..The effect saturated at approximately 450 mOsm x l(-1) and at approximately 24 h. Expression of aquaporin-5 (AQP5), studied by immunofluorescence and confocal microscopy, showed an increase in parallel with the increase in P(f ) ..
  43. Chang Y, Lin C, Wang H, Jian K, Liu S. Chlorpheniramine attenuates histamine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-?B activation. Int J Med Sci. 2017;14:1268-1275 pubmed publisher
    b>Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible for AQP5 regulation are still works in progress...
  44. Zhang J, Zhang G, Ni C, Cheng R, Liang J, Li M, et al. Nagashima-type palmoplantar keratosis in a Chinese Han population. Mol Med Rep. 2016;14:4049-4054 pubmed publisher
    ..Mutation screening was performed by direct sequencing of the entire coding regions of SERPINB7, SLURP1, AQP5, CSTA, KRT1 and KRT9 genes. Direct sequencing of SERPINB7 revealed five homozygous founder mutations (c...
  45. Wu H, Chen L, Zhang X, Zhou Q, Li J, Berger S, et al. Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2. PLoS ONE. 2013;8:e53342 pubmed publisher
    ..Here, we report that Aqp5 links Dot1l deletion to polyuria through Aqp2...
  46. Skowron zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F. Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation. Exp Cell Res. 2007;313:2695-702 pubmed
    ..We further show that aquaporin 5 expression, a water channel localized within the apical membrane of epithelial cells, is completely abolished ..
  47. Karoubi G, Cortes Dericks L, Breyer I, Schmid R, Dutly A. Identification of mesenchymal stromal cells in human lung parenchyma capable of differentiating into aquaporin 5-expressing cells. Lab Invest. 2009;89:1100-14 pubmed publisher
    ..In addition, when placed in small airway growth media, pHLP cell cultures depict the expression of aquaporin 5 and Clara cell secretory protein, which is identified with that of alveolar type I epithelial cells and Clara ..
  48. Qin X, Boron W. Mutation of a single amino acid converts the human water channel aquaporin 5 into an anion channel. Am J Physiol Cell Physiol. 2013;305:C663-72 pubmed publisher
    ..In the present study of human AQP5, we mutated Leu51 (corresponding to residue 61 in AQP6), the side chain of which faces the central pore...
  49. Pan B, Byrnes K, Schwartz M, Hansen C, Campbell C, Krupiczojc M, et al. Peripheral neuropathic changes in pachyonychia congenita. Pain. 2016;157:2843-2853 pubmed
    ..callused plantar skin from healthy runners with callus and one subject with a nonpainful palmoplantar keratoderma (AQP5 mutation) were similar to PC-unaffected and control skin consistent with callus alone not being sufficient to ..
  50. Madeira A, Mósca A, Moura T, Soveral G. Aquaporin-5 is expressed in adipocytes with implications in adipose differentiation. IUBMB Life. 2015;67:54-60 pubmed publisher
    ..Recently, AQP5 was described as a regulator of other AQP isoforms...
  51. Bhattarai K, Junjappa R, Handigund M, Kim H, Chae H. The imprint of salivary secretion in autoimmune disorders and related pathological conditions. Autoimmun Rev. 2018;17:376-390 pubmed publisher
    ..In this review, we focused mainly on the proteins responsible for deficient saliva, the correlation between inflammation and salivation, autoimmune disorders and other ailments or complications associated with hyposalivation. ..
  52. Gouda Z, Khalifa M, Shalaby S, Hussein S. Mechanistic effect of human umbilical cord blood derived-mesenchymal stem cells on the submandibular salivary gland in ovariectomized rats. Biochem Cell Biol. 2017;: pubmed publisher
    ..RT-PCR for AQP3, AQP4, AQP5 and BMP6 gene expression was determined...
  53. Jung H, Park J, Jeon H, Kwon T. Aquaporin-5: a marker protein for proliferation and migration of human breast cancer cells. PLoS ONE. 2011;6:e28492 pubmed publisher
    ..We aimed to examine the potential role of AQP5 in the progression of human breast cancer cells...
  54. Moehren U, Denayer S, Podvinec M, Verrijdt G, Claessens F. Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes. Biochem J. 2008;411:679-86 pubmed publisher
    ..Our data indicate the validity of the hypothesis that selective AREs are recognizable as direct 5'-TGTTCT-3' repeats, and extend the list of currently known selective elements. ..
  55. Chen Z, Wang X, Gao L, Bai L, Zhu R, Bai C. Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells. Biochem Biophys Res Commun. 2006;342:775-81 pubmed
    ..The present study aimed to examine whether AQP5 was involved in modulation of mucin expression and secretion in airway submucosal gland cells (SPC-A1)...
  56. Rossi L, Nicoletti M, Carmosino M, Mastrofrancesco L, Di Franco A, Indrio F, et al. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. J Diabetes Res. 2017;2017:4360357 pubmed publisher
    ..In this work, we analyzed the urine excretion of AQP5 and AQP2 (uAQP5 and uAQP2), via exosomes, in 35 diabetic patients: 12 normoalbuminuric with normal renal ..
  57. Hansel N, Sidhaye V, Rafaels N, Gao L, Gao P, Williams R, et al. Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease. PLoS ONE. 2010;5:e14226 pubmed publisher
    Aquaporin-5 (AQP5) can cause mucus overproduction and lower lung function. Genetic variants in the AQP5 gene might be associated with rate of lung function decline in chronic obstructive pulmonary disease (COPD)...
  58. Lee B, Gauna A, Perez G, Park Y, Pauley K, Kawai T, et al. Autoantibodies against muscarinic type 3 receptor in Sjögren's syndrome inhibit aquaporin 5 trafficking. PLoS ONE. 2013;8:e53113 pubmed publisher
    ..type 3 receptor (?-M3R) autoantibodies in patients with SjS inhibit intracellular trafficking of aquaporin-5 (AQP5), water transport protein, leading to secretory dysfunction...
  59. Silberstein C, Kierbel A, Amodeo G, Zotta E, Bigi F, Berkowski D, et al. Functional characterization and localization of AQP3 in the human colon. Braz J Med Biol Res. 1999;32:1303-13 pubmed
    ..The presence of AQP3 in villus epithelial cells suggests that AQP3 is implicated in water absorption across human colonic surface cells. ..
  60. Zhang J, Zhong L, Wang Y, Liu L, Cong X, Xiang R, et al. Proteomic analysis reveals an impaired Ca2+/AQP5 pathway in the submandibular gland in hypertension. Sci Rep. 2017;7:14524 pubmed publisher
    ..Specifically, aquaporin 5 and parvalbumin, which are correlated with water transport and intracellular Ca2+ signal ..
  61. Wang J, Kong H, Xu J, Wang Y, Wang H, Xie W. Fasudil alleviates LPS-induced lung Injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs. J Biomed Res. 2017;: pubmed publisher
    ..Further, fasudil upregulated LPS-induced aquaporin 5 reduction and inhibited NF-kB activation in the lungs of mice...
  62. Hub J, de Groot B. Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc Natl Acad Sci U S A. 2008;105:1198-203 pubmed publisher
    ..Hence, a hydrophobic effect, together with steric restraints, determines the selectivity of aquaporins. ..
  63. Nishio N, Teranishi M, Uchida Y, Sugiura S, Ando F, Shimokata H, et al. Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor ? in patients with Ménière's disease and sudden sensorineural hearing loss. Life Sci. 2013;92:541-6 pubmed publisher
    ..We investigated the associations between genetic polymorphisms in aquaporin 4 (AQP4, rs2075575), aquaporin 5 (AQP5, rs3736309), and estrogen receptor ? (ER?1, rs2234693; ER?2, rs9340799) and susceptibility to Ménière's ..
  64. Varadaraj K, Kumari S, Patil R, Wax M, Mathias R. Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract. Exp Eye Res. 2008;87:9-21 pubmed publisher
    ..Cataracts in patients with this mutation might have resulted from the above mentioned consequences. ..
  65. Ohgusu Y, Ohta K, Ishii M, Katano T, Urano K, Watanabe J, et al. Functional characterization of human aquaporin 9 as a facilitative glycerol carrier. Drug Metab Pharmacokinet. 2008;23:279-84 pubmed
  66. Ishibashi K, Morinaga T, Kuwahara M, Sasaki S, Imai M. Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta. 2002;1576:335-40 pubmed
    ..The genome structure of AQP10 is similar to those of other aquaglyceroporins (AQP3, AQP7, AQP9) with six exons. We conclude that AQP10 represents a new member of aquaglyceroporins functionally as well as structurally. ..
  67. Francis P, Chung J, Yasui M, Berry V, Moore A, Wyatt M, et al. Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum Mol Genet. 2000;9:2329-34 pubmed
    ..Moreover, these observations predict that less severe defects in the AQP0 protein may contribute to lens opacity in patients with common, less fulminant forms of cataracts. ..
  68. Verkman A, Mitra A. Structure and function of aquaporin water channels. Am J Physiol Renal Physiol. 2000;278:F13-28 pubmed
    ..Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also ..
  69. Zhang T, Zhao C, Chen D, Zhou Z. Overexpression of AQP5 in cervical cancer: correlation with clinicopathological features and prognosis. Med Oncol. 2012;29:1998-2004 pubmed publisher
    Accumulating evidence for overexpression of AQP5 in various types of human cancer suggests that it plays a key role in tumor biology. However, little is known about the function of AQP5 in human cervical cancer...
  70. Kang B, Kim J, Lee S, Chae Y, Yoon G, Park S, et al. Expression of aquaporin-1, aquaporin-3, and aquaporin-5 correlates with nodal metastasis in colon cancer. Oncology. 2015;88:369-76 pubmed publisher
    The clinical significance of aquaporin-1 (AQP1), aquaporin-3 (AQP3), and aquaporin-5 (AQP5) expression was analyzed in a large number of patients with colon cancer...
  71. Lu Y, Chen L, Zhao B, Xiao Z, Meng T, Zhou Q, et al. Urine AQP5 is a potential novel biomarker of diabetic nephropathy. J Diabetes Complications. 2016;30:819-25 pubmed publisher
    To investigate if urinary AQP5 serves as a new potential biomarker of diabetic nephropathy...
  72. Koyama N, Ishibashi K, Kuwahara M, Inase N, Ichioka M, Sasaki S, et al. Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene. Genomics. 1998;54:169-72 pubmed
    ..AQP8 was not permeable to urea nor to glycerol. The AQP8 gene has five introns, and the locations of exon-intron boundaries were different from those of the other mammalian aquaporins, suggesting its separate phylogenetic origin. ..
  73. Yasui M, Kwon T, Knepper M, Nielsen S, Agre P. Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Proc Natl Acad Sci U S A. 1999;96:5808-13 pubmed
    ..Moreover, our studies predict that AQP6 participates in distinct physiological functions such as glomerular filtration, tubular endocytosis, and acid-base metabolism. ..
  74. Krøigård A, Hetland L, Clemmensen O, Blaydon D, Hertz J, Bygum A. The first Danish family reported with an AQP5 mutation presenting diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type, hyperhidrosis and frequent Corynebacterium infections: a case report. BMC Dermatol. 2016;16:7 pubmed publisher
    ..of Bothnian type, is caused by mutations in the AQP5 gene encoding the cell-membrane water channel protein aquaporin 5 leading to defective epidermal-water-barrier function in the epidermis of the palms and soles...
  75. Guo X, Sun T, Yang M, Li Z, Li Z, Gao Y. Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma. Biomed Res Int. 2013;2013:206525 pubmed publisher
    Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC)...
  76. Chen X, Yang J, Zheng W. [Effect of topotecan on expression of aquaporin protein 5 and nuclear factor-kappaB in ovarian cancer SKOV3 cells]. Ai Zheng. 2009;28:856-60 pubmed
    Overexpression of aquaporin protein 5 (AQP5) is associated with the metastasis, migration and angiogenesis of ovarian cancer, but its function in cell proliferation has not been described...
  77. Chang Y, Jian K, Lin C, Wang H, Liu S. Dexamethasone attenuates methacholine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-?B activation. Int Forum Allergy Rhinol. 2017;: pubmed publisher
    ..However, its role in airway surface liquid homeostasis and aquaporin 5 (AQP5) regulation remains unclear...
  78. Hollborn M, Vogler S, Reichenbach A, Wiedemann P, Bringmann A, Kohen L. Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Mol Vis. 2015;21:360-77 pubmed
    ..Hyperosmolarity also increased the gene expression of AQP5 and AQP8, induced the phosphorylation of p38 MAPK and ERK1/2, increased the expression of HIF-1α and NFAT5, and ..
  79. Guo K, Jin F. NFAT5 promotes proliferation and migration of lung adenocarcinoma cells in part through regulating AQP5 expression. Biochem Biophys Res Commun. 2015;465:644-9 pubmed publisher
    ..decreased proliferation and migration of the cells, accompanied by a significant reduction in the expression of AQP5. AQP5 was upregulated in lung adenocarcinoma cells and knockdown of AQP5 also inhibited proliferation and migration ..