Gene Symbol: AQP1
Description: aquaporin 1 (Colton blood group)
Alias: AQP-CHIP, CHIP28, aquaporin-1, aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group), aquaporin 1, Colton blood group antigen, aquaporin-CHIP, channel-like integral membrane protein, 28-kDa, urine water channel, water channel protein for red blood cells and kidney proximal tubule
Species: human
Products:     AQP1

Top Publications

  1. Gao J, Tan M, Gu M, Marshall C, Ding J, Hu G, et al. Cellular localization of aquaporin-1 in the human and mouse trigeminal systems. PLoS ONE. 2012;7:e46379 pubmed publisher
    ..Previous studies reported that a subpopulation of mouse and rat trigeminal neurons express water channel aquaporin-1 (AQP1). In this study we make a comparative investigation of AQP1 localization in the human and mouse trigeminal systems...
  2. Chen Y, Tachibana O, Oda M, Xu R, Hamada J, Yamashita J, et al. Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation. J Neurooncol. 2006;80:219-25 pubmed
    ..Recently, expression of aquapporin 1 (AQP1) was found to be involved in not only water transport but also tumorigenesis...
  3. Ma T, Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998;273:4296-9 pubmed
    Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia...
  4. Conner M, Conner A, Brown J, Bill R. Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity. Biochemistry. 2010;49:821-3 pubmed publisher
    ..fusion proteins expressed in HEK293 cells, we demonstrate the reversible manipulation of cellular trafficking of AQP1. AQP1 trafficking was mediated by the tonicity of the cell environment in a specific PKC- and microtubule-dependent ..
  5. Saadoun S, Papadopoulos M, Davies D, Bell B, Krishna S. Increased aquaporin 1 water channel expression in human brain tumours. Br J Cancer. 2002;87:621-3 pubmed
    b>Aquaporin 1 is a water channel protein. There was little aquaporin 1 immunoreactivity in normal brain parenchyma. In astrocytomas, aquaporin 1 was expressed in microvessel endothelia and neoplastic astrocytes...
  6. Saadoun S, Papadopoulos M, Hara Chikuma M, Verkman A. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92 pubmed
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  7. McCoy E, Sontheimer H. Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia. 2007;55:1034-43 pubmed
    ..All glioma patient biopsies expressed AQP1, AQP4 and some expressed AQP5...
  8. Ren G, Reddy V, Cheng A, Melnyk P, Mitra A. Visualization of a water-selective pore by electron crystallography in vitreous ice. Proc Natl Acad Sci U S A. 2001;98:1398-403 pubmed
    ..The apex of the curved pore is close to the locations of the in-plane pseudo-2-fold symmetry axis that relates the N- and C-terminal halves and the conserved, functionally important N76 and N192 residues. ..
  9. Buck T, Wagner J, Grund S, Skach W. A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization. Nat Struct Mol Biol. 2007;14:762-9 pubmed
    ..We now show that in AQP1 these residues (Asn49 and Lys51) interact with Asp185 at the C terminus of TM5 to form a polar, quaternary ..

More Information


  1. Nico B, Ribatti D. Role of aquaporins in cell migration and edema formation in human brain tumors. Exp Cell Res. 2011;317:2391-6 pubmed publisher
    ..This review article summarizes literature data concerning the involvement of AQP-1 and -4 in human brain tumor growth and edema formation and suggests a potential therapeutic approach by antagonizing their biological activity. ..
  2. Baetz N, Hoffman E, Yool A, Stamer W. Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Exp Eye Res. 2009;89:95-100 pubmed publisher
    Aquaporin-1 (AQP1) channels are expressed by trabecular meshwork (TM) and Schlemm's canal cells of the conventional outflow pathway where fluid movement is predominantly paracellular, suggesting a non-canonical role for AQP1...
  3. Preston G, Smith B, Zeidel M, Moulds J, Agre P. Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science. 1994;265:1585-7 pubmed
    ..Surprisingly, none of the three suffers any apparent clinical consequence, which raises questions about the physiological importance of CHIP and implies that other mechanisms may compensate for its absence. ..
  4. Moftakhar P, Lynch M, Pomakian J, Vinters H. Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. J Neuropathol Exp Neurol. 2010;69:1201-9 pubmed publisher
    ..We investigated the expression of aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in 24 human autopsy brains consisting of 18 with AD and varying degrees of CAA ..
  5. Kaneko K, Yagui K, Tanaka A, Yoshihara K, Ishikawa K, Takahashi K, et al. Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc Res. 2008;75:297-301 pubmed publisher
    b>Aquaporin 1 (AQP1) was first purified from red blood cell membranes and is now known to be an osmolarity-driven water transporter that is widely expressed in many epithelial and endothelial cells outside the brain...
  6. Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H. Human astrocytes express aquaporin-1 and aquaporin-4 in vitro and in vivo. Neuropathology. 2007;27:245-56 pubmed
    ..Previous studies indicate that AQP1 is expressed exclusively in the choroid plexus epithelium, while AQP4 is localized on the vascular foot of ..
  7. Otterbach F, Callies R, Kimmig R, Schmid K, Bankfalvi A. [Aquaporin 1 expression in invasive breast carcinomas]. Pathologe. 2008;29 Suppl 2:357-62 pubmed publisher
    Aquaporin1 (AQP1) is a water channel protein which facilitates water flux across cell membranes. AQP1 is found in epithelial and endothelial cells in various tissues...
  8. Otterbach F, Callies R, Adamzik M, Kimmig R, Siffert W, Schmid K, et al. Aquaporin 1 (AQP1) expression is a novel characteristic feature of a particularly aggressive subgroup of basal-like breast carcinomas. Breast Cancer Res Treat. 2010;120:67-76 pubmed publisher
    Aquaporin1 (AQP1) is a water channel protein that facilitates water flux across cell membranes. It is widely expressed in epithelial and endothelial cells in several tissues...
  9. Preston G, Agre P. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. Proc Natl Acad Sci U S A. 1991;88:11110-4 pubmed
    b>CHIP28 is a 28-kDa integral membrane protein with similarities to membrane channels and is found in erythrocytes and renal tubules...
  10. Hoque M, Soria J, Woo J, Lee T, Lee J, Jang S, et al. Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol. 2006;168:1345-53 pubmed reverse transcriptase-polymerase chain reaction and Western blot analysis and identified clear expression of aquaporin 1 (AQP1) in seven cell lines...
  11. Badaut J, Brunet J, Grollimund L, Hamou M, Magistretti P, Villemure J, et al. Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue. Acta Neurochir Suppl. 2003;86:495-8 pubmed
    ..Despite recent reports that have shown an over-expression of AQP1 and 4 in human tumoral cells, little is known about AQP expression in human brain...
  12. Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann J, et al. Structural determinants of water permeation through aquaporin-1. Nature. 2000;407:599-605 pubmed
    Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8A resolution from electron crystallographic data...
  13. Yool A, Weinstein A. New roles for old holes: ion channel function in aquaporin-1. News Physiol Sci. 2002;17:68-72 pubmed
    ..Intriguing links exist in structural and functional properties between aquaporins and ion channels. A novel role for aquaporin-1 as a gated ion channel reshapes our current views of this ancient family of transmembrane channel proteins. ..
  14. de Groot B, Grubmuller H. Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. Science. 2001;294:2353-7 pubmed
    quot;Real time" molecular dynamics simulations of water permeation through human aquaporin-1 (AQP1) and the bacterial glycerol facilitator GlpF are presented...
  15. Dohke Y, Turner R. Evidence that the transmembrane biogenesis of aquaporin 1 is cotranslational in intact mammalian cells. J Biol Chem. 2002;277:15215-9 pubmed
    ..studies with Xenopus oocytes and dog pancreatic microsomes have suggested that this is not the case for human aquaporin 1 (AQP1)...
  16. Walz T, Smith B, Agre P, Engel A. The three-dimensional structure of human erythrocyte aquaporin CHIP. EMBO J. 1994;13:2985-93 pubmed
    ..Although CHIP monomers behave as independent pores, we propose that their particular structure requires tetramerization for stable integration into the bilayer. ..
  17. Cowan C, Yokoyama N, Bianchi L, Henkemeyer M, Fritzsch B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000;26:417-30 pubmed
    ..This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water. ..
  18. Preston G, Jung J, Guggino W, Agre P. The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. J Biol Chem. 1993;268:17-20 pubmed
    ..Molecular identification of CHIP28 protein as the membrane water channel was first accomplished by measurement of osmotic swelling of Xenopus oocytes ..
  19. Monzani E, Bazzotti R, Perego C, La Porta C. AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS ONE. 2009;4:e6167 pubmed publisher
    b>AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues...
  20. Sui H, Han B, Lee J, Walian P, Jap B. Structural basis of water-specific transport through the AQP1 water channel. Nature. 2001;414:872-8 pubmed
    ..Here we report the structure of the aquaporin 1 (AQP1) water channel to 2.2 A resolution...
  21. Umenishi F, Schrier R. Identification and characterization of a novel hypertonicity-responsive element in the human aquaporin-1 gene. Biochem Biophys Res Commun. 2002;292:771-5 pubmed
    The AQP1 gene is transcriptionally upregulated in response to hypertonicity. However, the molecular mechanism in hypertonicity-induced transcription in the AQP1 gene has been poorly understood...
  22. Denker B, Smith B, Kuhajda F, Agre P. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem. 1988;263:15634-42 pubmed
    ..A novel integral membrane protein has been purified from erythrocyte and kidney membranes. This new protein may play a role in linkage of the membrane skeleton to the lipid bilayer. ..
  23. Johnson M, O CONNELL M. Na-K-2Cl cotransporter and aquaporin 1 in arachnoid granulations, meningiomas, and meningiomas invading dura. Hum Pathol. 2013;44:1118-24 pubmed publisher
    ..Combined Na-K-2Cl cotransporter (NKCC1) and aquaporin 1 (AQP1) expression in arachnoid granulations and meningiomas with and without dural invasion has not been ..
  24. Hayashi Y, Edwards N, Proescholdt M, Oldfield E, Merrill M. Regulation and function of aquaporin-1 in glioma cells. Neoplasia. 2007;9:777-87 pubmed
    ..We sought to gain insight into AQP1 function in GBM...
  25. Walz T, Hirai T, Murata K, Heymann J, Mitsuoka K, Fujiyoshi Y, et al. The three-dimensional structure of aquaporin-1. Nature. 1997;387:624-7 pubmed
    ..protein of relative molecular mass 28,000, identified it as the mercury-sensitive water channel, aquaporin-1 (AQP1). Many related proteins, all belonging to the major intrinsic protein (MIP) family, are found throughout nature...
  26. Magni F, Chinello C, Raimondo F, Mocarelli P, Kienle M, Pitto M. AQP1 expression analysis in human diseases: implications for proteomic characterization. Expert Rev Proteomics. 2008;5:29-43 pubmed publisher
    ..known and they are divided into two subgroups according to their ability to transport only water molecules, such as AQP1, or also glycerol and other small solutes...
  27. Wakayama Y, Inoue M, Takahashi J. Aquaporin 1 may be involved in the pathophysiology of migraine: a hypothesis. Headache. 2007;47:1457-8 pubmed
  28. Zou L, Shi S, Zhang R, Wang T, Tan Y, Zhang D, et al. Aquaporin-1 plays a crucial role in estrogen-induced tubulogenesis of vascular endothelial cells. J Clin Endocrinol Metab. 2013;98:E672-82 pubmed publisher
    Aquaporin-1 (AQP1) has been proposed as a mediator of estrogen-induced angiogenesis in human breast cancer and endometrial cancer...
  29. King L, Choi M, Fernandez P, Cartron J, Agre P. Defective urinary concentrating ability due to a complete deficiency of aquaporin-1. N Engl J Med. 2001;345:175-9 pubmed
  30. Rodriguez A, Pérez Gracia E, Espinosa J, Pumarola M, Torres J, Ferrer I. Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Acta Neuropathol. 2006;112:573-85 pubmed examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex (area 8) homogenates of sporadic CJD cases (six men, four ..
  31. Stamer W, Bok D, Hu J, Jaffe G, McKay B. Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. Invest Ophthalmol Vis Sci. 2003;44:2803-8 pubmed
    ..Although AQP1 has been cloned from a cDNA library prepared from cultures of retinal pigment epithelial (RPE) cells isolated from ..
  32. King L, Nielsen S, Agre P, Brown R. Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc Natl Acad Sci U S A. 2002;99:1059-63 pubmed
    ..Aquaporins (AQP) are water-specific membrane channel proteins. AQP1 is present in endothelial cells in the lung, including those in the vascular plexus around the airways...
  33. Praetorius J, Nielsen S. Distribution of sodium transporters and aquaporin-1 in the human choroid plexus. Am J Physiol Cell Physiol. 2006;291:C59-67 pubmed
    ..This general cross species pattern suggests central roles for these transporters in choroid plexus functions such as cerebrospinal fluid production. ..
  34. Gao H, He C, Fang X, Hou X, Feng X, Yang H, et al. Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system. Glia. 2006;53:783-7 pubmed
    ..b>AQP1, AQP4, and AQP9 have been identified in the central nervous system and demonstrated or proposed to play important ..
  35. Voigtlaender J, Heindl B, Becker B. Transmembrane water influx via aquaporin-1 is inhibited by barbiturates and propofol in red blood cells. Naunyn Schmiedebergs Arch Pharmacol. 2002;366:209-17 pubmed
    Aquaporin-1 (AQP1) is known to be expressed at a high level in endothelial cell membranes and participates in water transfer into or across these cells...
  36. Smith B, Agre P. Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins. J Biol Chem. 1991;266:6407-15 pubmed
    ..The 28kDa protein has NH2-terminal amino acid sequence homology and membrane organization similar to major intrinsic protein and other members of a newly recognized family of transmembrane channel proteins. ..
  37. Chen L, Zhao J, Musa Aziz R, Pelletier M, Drummond I, Boron W. Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1163-74 pubmed publisher
    The mammalian aquaporins AQP1, AQP4, and AQP5 have been shown to function not only as water channels but also as gas channels. Zebrafish have two genes encoding an AQP1 homologue, aqp1a and aqp1b...
  38. Tejada M, Hashem N, Calloe K, Klaerke D. Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes. PLoS ONE. 2017;12:e0169914 pubmed publisher
    ..order to provide with the adequate water permeability to the cell membrane of Xenopus laevis oocytes, mRNA of aquaporin 1 was co-expressed with homomeric or heteromeric Slick and Slack ?-subunits...
  39. Verbavatz J, Brown D, Sabolic I, Valenti G, Ausiello D, van Hoek A, et al. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol. 1993;123:605-18 pubmed
    Channel forming integral protein of 28 kD (CHIP28) functions as a water channel in erythrocytes, kidney proximal tubule and thin descending limb of Henle...
  40. Udwan K, Brideau G, Fila M, EDWARDS A, Vogt B, Doucet A. Oxidative Stress and Nuclear Factor ?B (NF-?B) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome. J Biol Chem. 2016;291:11105-13 pubmed publisher
    ..Changes in water permeability were associated with the overexpression of the water channel aquaporin 1, which was prevented by reactive oxygen species scavenging and inhibition of NF-?B...
  41. Kida H, Miyoshi T, Manabe K, Takahashi N, Konno T, Ueda S, et al. Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line. J Membr Biol. 2005;208:55-64 pubmed
    ..Thus, it is concluded that AQP3 water channels serve as an essential pathway for volume-regulatory water transport in, human epithelial cells. ..
  42. Li H, Li G, Liu L, Guo Z, Ma X, Cao N, et al. Tumor interstitial fluid promotes malignant phenotypes of lung cancer independently of angiogenesis. Cancer Prev Res (Phila). 2015;8:1120-9 pubmed publisher
    ..Our results suggested that TIF could provide better nutrition to the tumor than angiogenesis and that it could promote the development of malignant phenotypes of lung cancer independently of angiogenesis. ..
  43. Wawrzkiewicz JaÅ‚owiecka A, Kowalczyk K, Pluta D, Blukacz Å, Madej P. The role of aquaporins in polycystic ovary syndrome - A way towards a novel drug target in PCOS. Med Hypotheses. 2017;102:23-27 pubmed publisher
    ..g. glycerol) through the cell membrane. There are twelve types of aquaporins (AQP1-AQP12) expressed in mammalian reproductive systems...
  44. Bogner B, Schroedl F, Trost A, Kaser Eichberger A, Runge C, Strohmaier C, et al. Aquaporin expression and localization in the rabbit eye. Exp Eye Res. 2016;147:20-30 pubmed publisher
    ..In the rabbit eye, AQP0 protein expression was restricted to the lens, while AQP1 was present in the cornea, the chamber angle, the iris, the ciliary body, the retina and, to a lower extent, in ..
  45. Li J, Zhang M, Mao Y, Li Y, Zhang X, Peng X, et al. The potential role of Aquaporin 1 on Aristolochic acid I induced Epithelial Mesenchymal Transition on HK-2 Cells. J Cell Physiol. 2017;: pubmed publisher
    ..Morphological examination, MTT assay, and Western blot analysis were performed. Aquaporin 1 (AQP1) and several EMT-related proteins were detected, thereby suggesting the occurrence of AA-I-induced EMT...
  46. Faragó N, Kocsis Ã, Braskó C, Lovas S, Rózsa M, Baka J, et al. Human neuronal changes in brain edema and increased intracranial pressure. Acta Neuropathol Commun. 2016;4:78 pubmed publisher
    ..In single pyramidal cells, mRNA copy numbers of AQP1, AQP3, HMOX1, KCNN4, SCN3B and SOD2 increased, while CACNA1B, CRH decreased in edema...
  47. Sepramaniam S, Armugam A, Lim K, Karolina D, Swaminathan P, Tan J, et al. MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia. J Biol Chem. 2010;285:29223-30 pubmed publisher
    ..Changes in aquaporin 1 and 4 expression in the brain are associated with cerebral edema, and the lack of water channel modulators is ..
  48. Kuwahara M, Gu Y, Ishibashi K, Marumo F, Sasaki S. Mercury-sensitive residues and pore site in AQP3 water channel. Biochemistry. 1997;36:13973-8 pubmed
    ..Mutation of Tyr-212, a position corresponding to the mercury-sensitive residues in AQP1 and AQP2, to cysteine enhanced the mercurial inhibition of Pf. Y212W had no water channel activity...
  49. Graziano A, Avola R, Pannuzzo G, Cardile V. Aquaporin1 and 3 modification as a result of chondrogenic differentiation of human mesenchymal stem cell. J Cell Physiol. 2017;: pubmed publisher
    ..In a recent period, AQP1 and 3 seem to have a role in metabolic water regulation in articular cartilage of load bearing joints...
  50. Khanna R. Solute and Water Transport in Peritoneal Dialysis: A Case-Based Primer. Am J Kidney Dis. 2017;69:461-472 pubmed publisher
    ..In addition to small pores, the peritoneal membrane contains a specialized water channel, aquaporin 1, which is also present in capillaries of the peritoneal membrane...
  51. Hassouneh R, Nasrallah R, Zimpelmann J, Gutsol A, Eckert D, Ghossein J, et al. PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes. Diabetologia. 2016;59:1318-28 pubmed publisher
    ..EP3 may prove to be a promising target for more selective management of diabetic kidney disease. ..
  52. Driml J, Pulford E, Moffat D, Karapetis C, Kao S, Griggs K, et al. Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas. Int J Mol Sci. 2016;17: pubmed publisher
    ..Survival is generally poor, but prognostication for individual patients is difficult. We recently described Aquaporin 1 (AQP1) as independent prognostic factor in two separate retrospective cohorts of MM patients...
  53. Tumer M, Demir M, Cicek M. Effect of aquaporin 1 and 4 on masticatory muscles degeneration as a result of aging. Bratisl Lek Listy. 2017;118:669-675 pubmed publisher
    ..The aim of this study was to evaluate the aging-related histopathologic changes and immunohistochemically assessed aquaporin 1 and 4 expressions on masseter and temporal muscles.
  54. Zeidel M, Ambudkar S, Smith B, Agre P. Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry. 1992;31:7436-40 pubmed
    ..b>CHIP28 is an abundant integral membrane protein in RBCs and renal tubules, and Xenopus laevis oocytes injected with ..
  55. Luo Y, Chen Q, Luan J, Chung S, Van Eck J, Turgeon R, et al. Towards an understanding of the molecular basis of effective RNAi against a global insect pest, the whitefly Bemisia tabaci. Insect Biochem Mol Biol. 2017;88:21-29 pubmed publisher
    ..dsRNA against the nuclease genes was co-administered with dsRNA against two insect genes, an aquaporin AQP1 and sucrase SUC1, that are predicted to protect B. tabaci against osmotic collapse...
  56. Mazal P, Stichenwirth M, Koller A, Blach S, Haitel A, Susani M. Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study. Mod Pathol. 2005;18:535-40 pubmed
    ..Aquaporin-1 and PAX-2 are reliable markers for clear cell renal cell carcinomas of lower grades but not for higher grades. CD10 expression remains stable, independent of nuclear grading. ..
  57. Hashmi G, Shariff T, Seul M, Vissavajjhala P, Hue Roye K, Charles Pierre D, et al. A flexible array format for large-scale, rapid blood group DNA typing. Transfusion. 2005;45:680-8 pubmed
    ..It has been shown that microarray technology can be used to type DNA and detect new alleles in donor cohorts. ..
  58. Pan H, Sun C, Zhou C, Huang H. Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria. Int J Gynaecol Obstet. 2008;101:239-44 pubmed publisher
    To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma...
  59. Missner A, Kügler P, Saparov S, Sommer K, Mathai J, Zeidel M, et al. Carbon dioxide transport through membranes. J Biol Chem. 2008;283:25340-7 pubmed publisher
    Several membrane channels, like aquaporin-1 (AQP1) and the RhAG protein of the rhesus complex, were hypothesized to be of physiological relevance for CO(2) transport...
  60. Liu W, Liu Y, Qin X, Schmidt S, Hauser M, Allingham R. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. Mol Vis. 2010;16:93-7 pubmed
    ..We investigated the association of variants in two candidate genes that are important in CSF production, aquaporin 1 (AQP1) and solute carrier family 4, sodium bicarbonate transporter, member 10 (SLC4A10), with POAG in the ..
  61. Wang Y, Bu J, Zhang Q, Chen K, Zhang J, Bao X. Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema. Mol Med Rep. 2015;12:5625-32 pubmed publisher
    ..The expression of AQP1, AQP2, AQP3 and AQP4 in kidney tissues from these patients was assessed using immunohistochemistry, and urinary AQP ..
  62. Vilas G, Krishnan D, Loganathan S, Malhotra D, Liu L, Beggs M, et al. Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction. Mol Biol Cell. 2015;26:1106-18 pubmed publisher
    Aquaporin-1 (AQP1) enables greatly enhanced water flux across plasma membranes. The cytosolic carboxy terminus of AQP1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences...
  63. Li Z, Zhao Z, Wen J, Xing L, Zhang H, Zhang Y. Early alteration of urinary exosomal aquaporin 1 and transforming growth factor ?1 after release of unilateral pelviureteral junction obstruction. J Pediatr Surg. 2012;47:1581-6 pubmed publisher
    Down-regulation of aquaporin 1 (AQP1) and up-regulation of transforming growth factor ?(1) (TGF-?(1)) in the renal parenchyma have been demonstrated in children who underwent pyeloplasty for pelviureteral junction obstruction...
  64. Xing L, Nørregaard R. Influence of sex on aquaporin1-4 and vasopressin V2 receptor expression in the pig kidney during development. Pediatr Res. 2016;80:452-9 pubmed publisher
    ..Here we investigated a possible sex difference in AQP1, AQP2, AQP3, and AQP4 as well as V2R expression in the fetal pig kidney at different gestation stages...
  65. Castorina A, Loreto C, Vespasiani G, Giunta S, Musumeci G, Castorina S, et al. Increased aquaporin 1 expression in the tunica albuginea of Peyronie's disease patients: an in vivo pilot study. Histol Histopathol. 2016;31:1241-9 pubmed publisher
    ..b>Aquaporin 1 (AQP1) is a water channel protein potentially implicated in connective tissue resistance to mechanical stress, ..
  66. Hoshi A, Tsunoda A, Tada M, Nishizawa M, Ugawa Y, Kakita A. Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease. Brain Pathol. 2017;27:160-168 pubmed publisher
    The astrocytic water channel proteins aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be altered in brains affected by several neurodegenerative disorders, including Alzheimer's disease...
  67. Pei H, Liu Z, Huang L, Zhu H. [Significance of aquaporin-1 and aquaporin-3 expression in colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi. 2011;14:275-8 pubmed
    ..05). AQP-1 expression is increased in CRC while the expression of AQP-3 is not. There is no correlation between the expression of AQP-1 and AQP-3 in CRC. ..
  68. Gouda Z, Khalifa M, Shalaby S, Hussein S. Mechanistic effect of human umbilical cord blood derived-mesenchymal stem cells on the submandibular salivary gland in ovariectomized rats. Biochem Cell Biol. 2017;: pubmed publisher
    ..CD34, anti-proliferating nuclear antigen (PCNA), anti-single stranded DNA(ssDNA), anti-Caspase 3, anti-aquaporin 1(AQP1) and anti-? smooth muscle actin(?-SMA) were determined immunohistochemically...
  69. Bellezza G, Vannucci J, Bianconi F, Metro G, Del Sordo R, Andolfi M, et al. Prognostic implication of aquaporin 1 overexpression in resected lung adenocarcinoma. Interact Cardiovasc Thorac Surg. 2017;25:856-861 pubmed publisher
    ..Specifically, AQP1 and AQP5 overexpression in lung adenocarcinoma (AC) have been suggested to be involved in molecular mechanisms in ..
  70. Petrova R, Webb K, Vaghefi E, Walker K, Schey K, Donaldson P. Dynamic functional contribution of the water channel AQP5 to the water permeability of peripheral lens fiber cells. Am J Physiol Cell Physiol. 2017;:ajpcell.00214.2017 pubmed publisher
    Although the functionality of the lens water channels, AQP1 (epithelium) and AQP0 (fiber cells), are well established less is known about the role of AQP5 in the lens...
  71. Moller C, Fotiadis D, Suda K, Engel A, Kessler M, Muller D. Determining molecular forces that stabilize human aquaporin-1. J Struct Biol. 2003;142:369-78 pubmed
    ..These results represent the first direct assessment of intermolecular forces defining the oligomeric state of a membrane protein. ..