APP

Summary

Gene Symbol: APP
Description: amyloid beta precursor protein
Alias: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, preA4, amyloid-beta A4 protein, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid precursor protein, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, cerebral vascular amyloid peptide, peptidase nexin-II, protease nexin-II, testicular tissue protein Li 2
Species: human
Products:     APP

Top Publications

  1. Muresan Z, Muresan V. The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration. Mol Biol Cell. 2007;18:3835-44 pubmed
    Phosphorylation of amyloid-beta precursor protein (APP) at Thr(668) is a normal process linked to neurite extension and anterograde transport of vesicular cargo...
  2. Granic A, Padmanabhan J, Norden M, Potter H. Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Mol Biol Cell. 2010;21:511-20 pubmed publisher
    ..mechanism underlying mosaic chromosome aneuploidy in AD and report that FAD mutations in the Alzheimer Amyloid Precursor Protein gene, APP, induce chromosome mis-segregation and aneuploidy in transgenic mice and in transfected cells...
  3. Guerreiro R, Baquero M, Blesa R, Boada M, Brás J, Bullido M, et al. Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP. Neurobiol Aging. 2010;31:725-31 pubmed publisher
    Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset (<65 years) Alzheimer's disease (AD)...
  4. Lee H, Kumar P, Fu Q, Rosen K, Querfurth H. The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol Biol Cell. 2009;20:1533-44 pubmed publisher
    Intraneuronal beta-amyloid (Abeta(i)) accumulates early in Alzheimer's disease (AD) and inclusion body myositis...
  5. Cheng N, Cai H, Belluscio L. In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function. J Neurosci. 2011;31:13699-704 pubmed publisher
    b>Amyloid precursor protein (APP) has long been linked to the neurodegeneration of Alzheimer's disease (AD), but the associated cell death has been difficult to capture in vivo, and the role of APP in effecting neuron loss is still unclear...
  6. Kienlen Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, et al. Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem. 2008;283:7733-44 pubmed publisher
    ..Abeta is produced by the sequential cleavage of the amyloid precursor protein (APP) by beta- and gamma-secretases...
  7. Müller T, Concannon C, Ward M, Walsh C, Tirniceriu A, Tribl F, et al. Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD). Mol Biol Cell. 2007;18:201-10 pubmed
    Amyloidogenic processing of the amyloid precursor protein (APP) results in the generation of beta-amyloid, the main constituent of Alzheimer plaques, and the APP intracellular domain (AICD)...
  8. Michaki V, Guix F, Vennekens K, Munck S, Dingwall C, Davis J, et al. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-? production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012;287:1100-11 pubmed publisher
    ..Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered ?-secretase processing of APP, and thus A? generation, without affecting Notch cleavage.
  9. Cruchaga C, Haller G, Chakraverty S, Mayo K, Vallania F, Mitra R, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PLoS ONE. 2012;7:e31039 pubmed publisher
    Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia...

More Information

Publications233 found, 100 shown here

  1. Burgos P, Mardones G, Rojas A, daSilva L, Prabhu Y, Hurley J, et al. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell. 2010;18:425-36 pubmed publisher
    ..we report the interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) with the mu4 subunit of AP-4...
  2. Millucci L, Ghezzi L, Bernardini G, Santucci A. Conformations and biological activities of amyloid beta peptide 25-35. Curr Protein Pept Sci. 2010;11:54-67 pubmed
    Amyloid-beta (Abeta) peptide is commonly found in human Alzheimer's disease (AD) brain and is the main component of Alzheimer amyloid plaques...
  3. De Chiara G, Marcocci M, Civitelli L, Argnani R, Piacentini R, Ripoli C, et al. APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells. PLoS ONE. 2010;5:e13989 pubmed publisher
    ..neurotoxic peptides, which occurs during amyloidogenic endoproteolytic processing of the transmembrane amyloid precursor protein (APP)...
  4. Kim T, Vidal G, Djurisic M, William C, Birnbaum M, Garcia K, et al. Human LilrB2 is a ?-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science. 2013;341:1399-404 pubmed publisher
    ..These findings imply that LilrB2 contributes to human AD neuropathology and suggest therapeutic uses of blocking LilrB2 function. ..
  5. Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, et al. Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J. 2013;32:2920-37 pubmed publisher
    ..Transgenic mice overexpressing Tau show TTLL6 translocalization into dendrites and decreased MT stability. The results provide a rationale for MT stabilization as a therapeutic approach. ..
  6. Yetman M, Jankowsky J. Wild-type neural progenitors divide and differentiate normally in an amyloid-rich environment. J Neurosci. 2013;33:17335-41 pubmed publisher
    ..We tested this hypothesis using a bigenic mouse in which transgenic expression of APP was restricted to mature projection neurons...
  7. Reinert J, Martens H, Huettenrauch M, Kolbow T, Lannfelt L, Ingelsson M, et al. A?38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models. J Alzheimers Dis. 2014;39:871-81 pubmed publisher
    ..Furthermore we demonstrate that A?38 deposits in the form of extracellular plaques are common in several AD transgenic mouse models carrying either only A?PP, or combinations of A?PP, PSEN1, and tau transgenes. ..
  8. Rijal Upadhaya A, Kosterin I, Kumar S, von Arnim C, Yamaguchi H, Fändrich M, et al. Biochemical stages of amyloid-? peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease. Brain. 2014;137:887-903 pubmed publisher
  9. Kwak Y, Hendrix B, Sugaya K. Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway. Biochem Biophys Res Commun. 2014;447:394-9 pubmed publisher
    ..peptides has been intensively studied within pathophysiology of AD, the physiological function of amyloid precursor protein (APP) still remains unclarified...
  10. Miyazaki T, Ikeda K, Horie Inoue K, Inoue S. Amyloid precursor protein regulates migration and metalloproteinase gene expression in prostate cancer cells. Biochem Biophys Res Commun. 2014;452:828-33 pubmed publisher
    b>Amyloid precursor protein (APP) is a type I transmembrane protein, and one of its processed forms, β-amyloid, is considered to play a central role in the development of Alzheimer's disease...
  11. Kaden D, Munter L, Joshi M, Treiber C, Weise C, Bethge T, et al. Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem. 2008;283:7271-9 pubmed publisher
    We found previously by fluorescence resonance energy transfer experiments that amyloid precursor protein (APP) homodimerizes in living cells...
  12. Suzuki T, Oishi M, Marshak D, Czernik A, Nairn A, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J. 1994;13:1114-22 pubmed
    Accumulation of the amyloid A beta peptide, which is derived from a larger precursor protein (APP), and the formation of plaques, are major events believed to be involved in the etiology of Alzheimer's disease...
  13. Belyaev N, Nalivaeva N, Makova N, Turner A. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 2009;10:94-100 pubmed publisher
    ..Considerable controversy surrounds whether the intracellular domain of the amyloid precursor protein (AICD) regulates expression of the Abeta-degrading metalloprotease, neprilysin (NEP)...
  14. van Helmond Z, Miners J, Kehoe P, Love S. Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy. Brain Pathol. 2010;20:468-80 pubmed publisher
    Despite accumulating evidence of a central role for oligomeric amyloid beta (Abeta) in the pathogenesis of Alzheimer's Disease (AD), there is scant information on the relationship between the levels and distribution of oligomeric Abeta ..
  15. Reiniger L, LUKIC A, Linehan J, Rudge P, Collinge J, Mead S, et al. Tau, prions and A?: the triad of neurodegeneration. Acta Neuropathol. 2011;121:5-20 pubmed publisher
    ..This includes the novel finding that tau phosphorylation consistently occurs in sporadic CJD, in the absence of amyloid plaques. ..
  16. Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, et al. The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. J Biol Chem. 2005;280:28912-6 pubmed
    ..is mainly composed by amyloid-beta (A(beta)) peptides, which are derive from processing of the beta-amyloid precursor protein (APP), better named amyloid-beta precursor protein (A(beta)PP), by secretases...
  17. Griffiths H, Whitehouse I, Baybutt H, Brown D, Kellett K, Jackson C, et al. Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J Biol Chem. 2011;286:33489-500 pubmed publisher
    In Alzheimer disease amyloid-? (A?) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the ?-secretase BACE1 is the rate-limiting step in the production of A?...
  18. von Rotz R, Kohli B, Bosset J, Meier M, Suzuki T, Nitsch R, et al. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci. 2004;117:4435-48 pubmed
    The physiological functions of the beta-amyloid precursor protein (APP) may include nuclear signaling...
  19. Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, et al. Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem. 2009;284:32895-905 pubmed publisher
    Amyloid beta-protein (Abeta) assemblies are thought to play primary roles in Alzheimer disease (AD)...
  20. Shipley S, Parkin E, Itzhaki R, Dobson C. Herpes simplex virus interferes with amyloid precursor protein processing. BMC Microbiol. 2005;5:48 pubmed
    ..This is cleaved from the much larger transmembranal protein 'amyloid precursor protein' (APP)...
  21. Teng L, Zhao J, Wang F, Ma L, Pei G. A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis. Cell Res. 2010;20:138-53 pubmed publisher
    ..beta-site APP-cleaving enzyme (BACE) and/or gamma-secretase leads to anomalous production of amyloid-beta peptide (Abeta) and contributes to the etiology of Alzheimer's disease (AD)...
  22. Vandersteen A, Masman M, De Baets G, Jonckheere W, van der Werf K, Marrink S, et al. Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-? peptide pool. J Biol Chem. 2012;287:36732-43 pubmed publisher
    ..Our results indicate that the complex in vivo A? peptide array and variations thereof is critical in Alzheimer disease, which can influence the selection of current and new therapeutic strategies. ..
  23. Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y. Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. J Neurosci. 2010;30:3924-32 pubmed publisher
    ..HRD1 is expressed in brain neurons and acts as an ERAD ubiquitin ligase. Amyloid precursor protein (APP) is processed into amyloid-beta peptides (Abetas) that form plaque deposits in the brains of ..
  24. Narayan P, Meehan S, Carver J, Wilson M, Dobson C, Klenerman D. Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones. Biochemistry. 2012;51:9270-6 pubmed publisher
    ..This conclusion suggests that these chaperones, both of which are ATP-independent, are able to inhibit potentially pathogenic Aβ oligomer-associated processes whether they occur in the extracellular or intracellular environment. ..
  25. Cai D, Leem J, Greenfield J, Wang P, Kim B, Wang R, et al. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem. 2003;278:3446-54 pubmed
    Presenilins (PS1/PS2) play a critical role in proteolysis of beta-amyloid precursor protein (beta APP) to generate beta-amyloid, a peptide important in the pathogenesis of Alzheimer's disease...
  26. Chafekar S, Hoozemans J, Zwart R, Baas F, Scheper W. Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid Redox Signal. 2007;9:2245-54 pubmed
    ..A potential source for UPR activation in AD neurons may be the increased levels of beta-amyloid (Abeta)...
  27. Mitchell J, Ariff B, Yates D, Lau K, Perkinton M, Rogelj B, et al. X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice. Hum Mol Genet. 2009;18:4492-500 pubmed publisher
    ..X11beta is a neuronal adaptor protein that binds to the intracellular domain of the amyloid precursor protein (APP). Overexpression of X11beta inhibits Abeta production in a number of experimental systems...
  28. Shankar G, Li S, Mehta T, Garcia Munoz A, Shepardson N, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008;14:837-42 pubmed publisher
    ..We extracted soluble amyloid-beta protein (Abeta) oligomers directly from the cerebral cortex of subjects with Alzheimer's disease...
  29. Bailey A, Hou H, Obregon D, Tian J, Zhu Y, Zou Q, et al. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-?: implications for autism. FASEB J. 2012;26:1040-51 pubmed publisher
    Abnormalities in T-lymphocyte populations and function are observed in autism. Soluble amyloid precursor protein ? (sAPP-?) is elevated in some patients with autism and is known to be produced by immune cells...
  30. Beher D, Hesse L, Masters C, Multhaup G. Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem. 1996;271:1613-20 pubmed
    The specific binding of the amyloid precursor protein (APP) to extracellular matrix molecules suggests that APP regulates cell interactions and has a function as a cell adhesion molecule and/or substrate adhesion molecule...
  31. Ghersi E, Vito P, Lopez P, Abdallah M, D ADAMIO L. The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. J Alzheimers Dis. 2004;6:67-78 pubmed
    ..As a result of two sequential proteolytic cleavages, AbetaPP releases the Amyloid-beta (Abeta) peptide, which accumulates in insoluble plaques in the brain of patients affected by Alzheimer's Disease (AD)...
  32. von Arnim C, Spoelgen R, Peltan I, Deng M, Courchesne S, Koker M, et al. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J Neurosci. 2006;26:9913-22 pubmed
    The beta-amyloid (Abeta) precursor protein (APP) is cleaved sequentially by beta-site of APP-cleaving enzyme (BACE) and gamma-secretase to release the Abeta peptides that accumulate in plaques in Alzheimer's disease (AD)...
  33. Xia W, Zhang J, Perez R, Koo E, Selkoe D. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc Natl Acad Sci U S A. 1997;94:8208-13 pubmed
    ..genes were stably transfected into Chinese hamster ovary cells expressing endogenous or transfected beta-amyloid precursor protein (APP)...
  34. Lau K, McLoughlin D, Standen C, Miller C. X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. Mol Cell Neurosci. 2000;16:557-65 pubmed
    X11 alpha and X11 beta are two neuronal adaptor proteins that interact with the Alzheimer's disease amyloid precursor protein (APP)...
  35. Rempel H, Pulliam L. HIV-1 Tat inhibits neprilysin and elevates amyloid beta. AIDS. 2005;19:127-35 pubmed
    Aging is a risk factor for amyloid beta (Abeta) accumulation and dementia...
  36. Kelly B, Vassar R, Ferreira A. Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. J Biol Chem. 2005;280:31746-53 pubmed
    ..We report here that beta-amyloid (Abeta), the main component of senile plaques, induced a significant decrease in dynamin 1, a protein that is essential ..
  37. Athan E, Lee J, Arriaga A, Mayeux R, Tycko B. Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease. Arch Neurol. 2002;59:1793-9 pubmed
    Missense mutations in the amyloid precursor protein (APP) gene cause early-onset Alzheimer disease (AD). However, little is known regarding the effects of polymorphisms in regulatory sequences of APP on AD susceptibility...
  38. Dolcini V, Dunys J, Sevalle J, Chen F, Guillot Sestier M, St George Hyslop P, et al. TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin. Biochem Biophys Res Commun. 2008;371:69-74 pubmed publisher
    ..This proteolytic complex has been shown to contribute to both gamma- and epsilon-cleavages of the beta-amyloid precursor protein (betaAPP), thereby generating beta-amyloid peptides (Abeta) and the APP intracellular domain (AICD), ..
  39. Sheng B, Song B, Zheng Z, Zhou F, Lu G, Zhao N, et al. Abnormal cleavage of APP impairs its functions in cell adhesion and migration. Neurosci Lett. 2009;450:327-31 pubmed publisher
    b>Amyloid precursor protein (APP) is expressed ubiquitously but its wrong cleavage only occurs in central nervous system...
  40. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, et al. RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci U S A. 2009;106:20021-6 pubmed publisher
    ..of Abeta and RAGE was observed in the hippocampus of transgenic mice overexpressing mutant amyloid precursor protein. These findings indicate that RAGE contributes to mechanisms involved in the translocation of Abeta from ..
  41. Venkataramani V, Rossner C, Iffland L, Schweyer S, Tamboli I, Walter J, et al. Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. J Biol Chem. 2010;285:10678-89 pubmed publisher
    The beta-amyloid precursor protein (APP) represents a type I transmembrane glycoprotein that is ubiquitously expressed. In the brain, it is a key player in the molecular pathogenesis of Alzheimer disease...
  42. Tarassishin L, Yin Y, Bassit B, Li Y. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci U S A. 2004;101:17050-5 pubmed
    ..We also explored the cellular processing sites of gamma-secretase for amyloid precursor protein (APP) and Notch by using small molecular probes...
  43. Zaghi J, Goldenson B, Inayathullah M, Lossinsky A, Masoumi A, Avagyan H, et al. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol. 2009;117:111-24 pubmed publisher
    ..Blood-borne macrophages might reduce Abeta stress to neurons by immigration into the brain and phagocytosis of Alphabeta...
  44. Hellstrand E, Boland B, Walsh D, Linse S. Amyloid ?-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. ACS Chem Neurosci. 2010;1:13-8 pubmed publisher
    ..0.2 ?M, after which free A? decreased with total A? toward an asymptotic value. Our results imply that A? fibril formation arises from a sequence of events in a highly predictable manner. ..
  45. Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn A, et al. Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci. 1999;19:4421-7 pubmed
    Alzheimer's amyloid precursor protein (APP), the precursor of beta-amyloid (Abeta), is an integral membrane protein with a receptor-like structure...
  46. Gestwicki J, Crabtree G, Graef I. Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science. 2004;306:865-9 pubmed
    ..To yield potent inhibitors of beta-amyloid (Abeta) aggregation, we synthesized small molecules that increase their steric bulk by binding to chaperones but also ..
  47. Carey R, Balcz B, Lopez Coviella I, Slack B. Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 2005;6:30 pubmed
    The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by alpha-secretase, or internalized within clathrin-coated vesicles...
  48. Qiang W, Yau W, Luo Y, Mattson M, Tycko R. Antiparallel ?-sheet architecture in Iowa-mutant ?-amyloid fibrils. Proc Natl Acad Sci U S A. 2012;109:4443-8 pubmed publisher
    ..Thus, our antiparallel D23N-A?(1-40) fibril model represents a specific "toxic intermediate" in the aggregation process of a disease-associated A? mutant. ..
  49. Pugh P, Richardson J, Bate S, Upton N, Sunter D. Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease. Behav Brain Res. 2007;178:18-28 pubmed
    ..reveal previously unreported disease relevant behavioural changes that demonstrate the value of measuring behaviour in APP/PS1 transgenic models. These behavioural readouts could be useful in screening putative drug treatments for AD.
  50. Eggert S, Midthune B, Cottrell B, Koo E. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem. 2009;284:28943-52 pubmed publisher
    The amyloid precursor protein (APP) plays a central role in Alzheimer disease (AD) pathogenesis because sequential cleavages by beta- and gamma-secretase lead to the generation of the amyloid-beta (Abeta) peptide, a key constituent in ..
  51. Mohamed A, Saavedra L, Di Pardo A, Sipione S, Posse de Chaves E. ?-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage. J Neurosci. 2012;32:6490-500 pubmed publisher
    ..In conclusion, we demonstrate a significant inhibitory effect of A? on protein prenylation and identify SREBP-2 as a target of oA?(42), directly linking A? to cholesterol homeostasis impairment. ..
  52. Koldamova R, Lefterov I, Lefterova M, Lazo J. Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity. Biochemistry. 2001;40:3553-60 pubmed
    b>Amyloid precursor protein (APP) is the source of the neurotoxic amyloid beta (Abeta) peptide associated with Alzheimer's disease...
  53. Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen P, et al. Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm (Vienna). 2010;117:85-96 pubmed publisher
    The presence of Abeta(pE3) (N-terminal truncated Abeta starting with pyroglutamate) in Alzheimer's disease (AD) has received considerable attention since the discovery that this peptide represents a dominant fraction of Abeta peptides in ..
  54. Liu S, Liu Y, Hao W, Wolf L, Kiliaan A, Penke B, et al. TLR2 is a primary receptor for Alzheimer's amyloid ? peptide to trigger neuroinflammatory activation. J Immunol. 2012;188:1098-107 pubmed publisher
    ..Our study demonstrated that TLR2 is a primary receptor for A? to trigger neuroinflammatory activation and suggested that inhibition of TLR2 in microglia could be beneficial in Alzheimer's disease pathogenesis. ..
  55. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, et al. Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem. 2003;278:49448-58 pubmed
    ..X11L stabilizes APP metabolism and suppresses the secretion of the amyloid beta-protein (Abeta) that are the pathogenic agents of Alzheimer's disease (AD)...
  56. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004;43:333-44 pubmed
    ..6-1.2 nM) compared to Abeta42 and mutant Abeta, and LRP-mediated Abeta brain capillary binding, endocytosis, and transcytosis across the mouse blood-brain ..
  57. Watanabe T, Hikichi Y, Willuweit A, Shintani Y, Horiguchi T. FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. J Neurosci. 2012;32:3352-65 pubmed publisher
    ..F-box and leucine rich repeat protein2 (FBL2), a component of the E3 ubiquitin ligase complex, regulates amyloid precursor protein (APP) metabolism through APP ubiquitination...
  58. Wahlström A, Hugonin L, Perálvarez Marín A, Jarvet J, Gräslund A. Secondary structure conversions of Alzheimer's Abeta(1-40) peptide induced by membrane-mimicking detergents. FEBS J. 2008;275:5117-28 pubmed publisher
    The amyloid beta peptide (Abeta) with 39-42 residues is the major component of amyloid plaques found in brains of Alzheimer's disease patients, and soluble oligomeric peptide aggregates mediate toxic effects on neurons...
  59. Liu Y, Jones M, Hingtgen C, Bu G, Laribee N, Tanzi R, et al. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med. 2000;6:1380-7 pubmed
    ..and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor protein and amyloid beta-protein...
  60. Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, et al. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci. 2001;21:6597-607 pubmed
    Using a yeast two-hybrid method, we searched for amyloid precursor protein (APP)-interacting molecules by screening mouse and human brain libraries...
  61. Hung Y, Robb E, Volitakis I, Ho M, Evin G, Li Q, et al. Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. J Biol Chem. 2009;284:21899-907 pubmed publisher
    ..Growing evidence suggests that amyloidogenic processing of the beta-amyloid precursor protein (APP) occurs in lipid rafts, membrane microdomains enriched in cholesterol...
  62. Volianskis A, Køstner R, Mølgaard M, Hass S, Jensen M. Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1?E9-deleted transgenic mice model of ß-amyloidosis. Neurobiol Aging. 2010;31:1173-87 pubmed publisher
    ..The accumulation of beta-amyloid and the episodic memory deficits, both of which increased with age, were not accompanied by an alteration in synaptic transmission or sustained LTP in the in vitro hippocampal slices. ..
  63. Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland D, et al. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem. 2008;283:34554-62 pubmed publisher
  64. Fossati S, Cam J, Meyerson J, Mezhericher E, Romero I, Couraud P, et al. Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls. FASEB J. 2010;24:229-41 pubmed publisher
    ..angiopathy (CAA) is an age-associated condition and a common finding in Alzheimer's disease in which amyloid-beta (Abeta) vascular deposits are featured in >80% of the cases...
  65. Massone S, Ciarlo E, Vella S, Nizzari M, Florio T, Russo C, et al. NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid ? secretion. Biochim Biophys Acta. 2012;1823:1170-7 pubmed publisher
    ..In this work we show that the NDM29-dependent cell maturation induces amyloid precursor protein (APP) synthesis, leading to the increase of amyloid ? peptide (A?) secretion and the concomitant ..