Gene Symbol: APOO
Description: apolipoprotein O
Alias: FAM121B, MIC26, Mic23, My025, MICOS complex subunit MIC26, MICOS complex subunit MIC23, brain my025, family with sequence similarity 121B
Species: human
Products:     APOO

Top Publications

  1. Perroud N, Uher R, Ng M, Guipponi M, Hauser J, Henigsberg N, et al. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. Pharmacogenomics J. 2012;12:68-77 pubmed publisher
    ..by gene interactions for two SNPs near structural variants on chromosome 4q12, one SNP in the apolipoprotein O (APOO) gene on chromosome Xp22.11 and one on chromosome 11q24.3 were found...
  2. Yu B, Wu C, Zhao S. Plasma apolipoprotein O level increased in the patients with acute coronary syndrome. J Lipid Res. 2012;53:1952-7 pubmed publisher
    ..However, overexpression of apoO does not impact on plasma HDL levels or functionality in human apoA-I transgenic mice...
  3. Lamant M, Smih F, Harmancey R, Philip Couderc P, Pathak A, Roncalli J, et al. ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart. J Biol Chem. 2006;281:36289-302 pubmed
    ..Apolipoprotein O may be involved in myocardium-protective mechanisms against lipid accumulation, or it may have specific properties mediated by its unique glycosylation pattern. ..
  4. Schmidinger B, Weijler A, Schneider W, Hermann M. Hepatosteatosis and estrogen increase apolipoprotein O production in the chicken. Biochimie. 2016;127:37-43 pubmed publisher
    Apolipoprotein O (ApoO) is a recently discovered plasma apolipoprotein that may also play a role in the mitochondrial inner membrane. Possibly due to this complexity, its physiological functions have not been elucidated yet...
  5. Weijler A, Schmidinger B, Kapiotis S, Laggner H, Hermann M. Oleic acid induces the novel apolipoprotein O and reduces mitochondrial membrane potential in chicken and human hepatoma cells. Biochimie. 2018;147:136-142 pubmed publisher
    ..Apolipoprotein O (ApoO) is a new member of the plasma apolipoprotein family that may play a role in lipid metabolism and electron ..
  6. Montasser M, O Hare E, Wang X, Howard A, McFarland R, Perry J, et al. An APOO Pseudogene on Chromosome 5q is Associated with LDL-C Levels. Circulation. 2018;: pubmed publisher
    ..b>Conclusions -Based on these data, we propose that APOOP1 regulates levels of LDL-C in humans, thus identifying a novel mechanism of lipid homeostasis. ..
  7. Koob S, Barrera M, Anand R, Reichert A. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. Biochim Biophys Acta. 2015;1853:1551-63 pubmed publisher
    ..Here we investigated the functional role of MIC26, a lipoprotein formerly termed APOO...
  8. Tian F, Wu C, Yu B, Liu L, Hu J. Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function. Biochem Biophys Res Commun. 2017;491:8-14 pubmed publisher
    Apolipoprotein O (ApoO) was recently observed in the cellular mitochondrial inner membrane, which plays a role in mitochondrial function and is associated with myocardiopathy...
  9. Wu C, Zhao S, Yu B. Microarray analysis provides new insights into the function of apolipoprotein O in HepG2 cell line. Lipids Health Dis. 2013;12:186 pubmed publisher
    Apolipoprotein O (apoO) is a new member of the apolipoprotein family. However, data on its physiological functions are limited and inconsistent...

More Information


  1. Yang Y, Fu Q, Zhou T, Li Y, Liu S, Zeng Q, et al. Analysis of apolipoprotein genes and their involvement in disease response of channel catfish after bacterial infection. Dev Comp Immunol. 2017;67:464-470 pubmed publisher
    ..infection, apoB-B, apoD-B, and apoE-A were significantly down-regulated in catfish gill, while apoF, apoL-IV, apoO-like, and apo-14 kDa showed significantly up-regulation...
  2. Turkieh A, Caubère C, Barutaut M, Desmoulin F, Harmancey R, Galinier M, et al. Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. J Clin Invest. 2014;124:2277-86 pubmed publisher
    ..obesity-associated cardiac gene expression, we previously identified and cloned the gene encoding apolipoprotein O (APOO), which is overexpressed in hearts from diabetic patients...
  3. Ott C, Dorsch E, Fraunholz M, Straub S, Kozjak Pavlovic V. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS ONE. 2015;10:e0120213 pubmed publisher
    ..We provide additional proof that ApoO indeed is a subunit of the MICOS and MIB complexes and propose the name Mic23 for this protein...
  4. Guarani V, McNeill E, Paulo J, Huttlin E, Fröhlich F, Gygi S, et al. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
    ..resulted in MICOS disassembly with the accumulation of a MIC60-MIC19-MIC25 sub-complex and degradation of MIC10, MIC26, and MIC27...