apolipoprotein M

Summary

Gene Symbol: apolipoprotein M
Description: apolipoprotein M
Alias: G3a, HSPC336, NG20, apo-M, NG20-like protein, alternative name: G3a, NG20, protein G3a
Species: human

Top Publications

  1. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
  2. doi Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism
    Ratna Karuna
    Institute of Clinical Chemistry, University and University Hospital Zurich, Switzerland
    Atherosclerosis 219:855-63. 2011
  3. doi Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M
    Madhumati Sevvana
    Lehrstuhl für Biotechnik, Department of Biology, Friedrich Alexander University Erlangen Nuremberg, Im IZMP, Henkestr 91, D 91052 Erlangen, Germany
    J Mol Biol 393:920-36. 2009
  4. doi Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chim Acta 406:129-33. 2009
  5. pmc Opposite regulation of the human apolipoprotein M gene by hepatocyte nuclear factor 1 and Jun transcription factors
    Ioanna Mosialou
    Department of Basic Sciences, University of Crete Medical School, Heraklion 71003, Greece
    J Biol Chem 286:17259-69. 2011
  6. pmc Apolipoprotein M gene (APOM) polymorphism modifies metabolic and disease traits in type 2 diabetes
    Jun Wei Zhou
    Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e17324. 2011
  7. ncbi Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis
    J Duan
    Center for Structural Biochemistry, Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    FEBS Lett 499:127-32. 2001
  8. ncbi Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects
    Ning Xu
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S 221 85 Lund, Sweden
    J Nutr Biochem 15:579-82. 2004
  9. pmc Increased plasma apoM levels in the patients suffered from hepatocellular carcinoma and other chronic liver diseases
    Jingting Jiang
    Department of Tumor Biological Treatment, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, PR China
    Lipids Health Dis 7:25. 2008
  10. ncbi A prospective evaluation of apolipoprotein M gene T-778C polymorphism in relation to coronary artery disease in Han Chinese
    Guo qing Jiao
    Department of Cardiovascular Surgery, Affiliated Shanghai 1st People s Hospital, Shanghai Jiaotong University, Hongkou 85 Wujin Road, Shanghai 200080, PR China
    Clin Biochem 40:1108-12. 2007

Research Grants

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
    ..We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did not...
  2. doi Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism
    Ratna Karuna
    Institute of Clinical Chemistry, University and University Hospital Zurich, Switzerland
    Atherosclerosis 219:855-63. 2011
    b>Apolipoprotein M (apoM) has been identified as a specific sphingosine-1-phosphate (S1P) binding protein of HDL.
  3. doi Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M
    Madhumati Sevvana
    Lehrstuhl für Biotechnik, Department of Biology, Friedrich Alexander University Erlangen Nuremberg, Im IZMP, Henkestr 91, D 91052 Erlangen, Germany
    J Mol Biol 393:920-36. 2009
    b>Apolipoprotein M (ApoM) is a 25-kDa HDL-associated apolipoprotein and a member of the lipocalin family of proteins...
  4. doi Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chim Acta 406:129-33. 2009
    ..Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM...
  5. pmc Opposite regulation of the human apolipoprotein M gene by hepatocyte nuclear factor 1 and Jun transcription factors
    Ioanna Mosialou
    Department of Basic Sciences, University of Crete Medical School, Heraklion 71003, Greece
    J Biol Chem 286:17259-69. 2011
    ..b>Apolipoprotein M (apoM) has been recently shown to play a role in the maturation of HDL in plasma and to protect from ..
  6. pmc Apolipoprotein M gene (APOM) polymorphism modifies metabolic and disease traits in type 2 diabetes
    Jun Wei Zhou
    Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e17324. 2011
    ..Further molecular analysis proved the functional activity of rs707922 in APOM expression and in regulation of cellular cholesterol content...
  7. ncbi Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis
    J Duan
    Center for Structural Biochemistry, Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    FEBS Lett 499:127-32. 2001
    b>Apolipoprotein M (apoM) is a novel apolipoprotein that is predominantly present in high-density lipoprotein...
  8. ncbi Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects
    Ning Xu
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S 221 85 Lund, Sweden
    J Nutr Biochem 15:579-82. 2004
    b>Apolipoprotein M (apoM) is a recently characterized apolipoprotein that is exclusively expressed in the liver and kidney. In plasma it is present predominantly in high-density lipoprotein (HDL)...
  9. pmc Increased plasma apoM levels in the patients suffered from hepatocellular carcinoma and other chronic liver diseases
    Jingting Jiang
    Department of Tumor Biological Treatment, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, PR China
    Lipids Health Dis 7:25. 2008
    To determine plasma apolipoprotein M (apoM) levels and other lipid profiles in hepatocellular carcinoma (HCC) patients compared to other chronic liver diseases and normal subjects.
  10. ncbi A prospective evaluation of apolipoprotein M gene T-778C polymorphism in relation to coronary artery disease in Han Chinese
    Guo qing Jiao
    Department of Cardiovascular Surgery, Affiliated Shanghai 1st People s Hospital, Shanghai Jiaotong University, Hongkou 85 Wujin Road, Shanghai 200080, PR China
    Clin Biochem 40:1108-12. 2007
    b>Apolipoprotein M (apoM) is important for the formation of pre-beta-high-density lipoprotein (HDL) and cholesterol efflux in macrophages...
  11. ncbi Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1
    Nicolas Venteclef
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France
    J Biol Chem 283:3694-701. 2008
    ..Here, we report the identification of apolipoprotein M (APOM) as a novel target gene for LRH-1...
  12. ncbi [Distribution characters and linkage disequilibrium analysis of APOM gene polymorphisms in Han population of North China]
    Xiu Jie Han
    Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, 100053 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:350-3. 2007
    To investigate the distribution characters and linkage disequilibrium of apolipoprotein M gene (APOM) polymorphisms in Han population of North China.
  13. ncbi Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
    Christian Wolfrum
    The Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 11:418-22. 2005
    ..Here we show that mice deficient in apolipoprotein M (apoM), a component of the HDL particle, accumulated cholesterol in large HDL particles (HDL(1)) while the ..
  14. doi Evaluation of apolipoprotein M as a biomarker of coronary artery disease
    Weiqiang Su
    Department of Cardiovascular Surgery, Affiliated Wuxi 2nd People s Hospital, Nanjing Medical University, Jiangsu, People s Republic of China
    Clin Biochem 42:365-70. 2009
    To investigate the possible role of apolipoprotein M (ApoM) in the development of coronary artery disease (CAD).
  15. ncbi A novel human apolipoprotein (apoM)
    N Xu
    Department of Clinical Chemistry, University of Lund, University Hospital, Malmo, S 20502 Malmo, Sweden
    J Biol Chem 274:31286-90. 1999
    A novel human apolipoprotein designated apolipoprotein M (apoM) is described...
  16. doi Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia
    Josefin Ahnström
    Lund University, Department of Laboratory Medicine, Division of Clinical Chemistry, Wallenberg Laboratory, Entrance 46, Floor 6, University Hospital, Malmo, S 20502 Malmo, Sweden
    Clin Biochem 43:599-603. 2010
    ..Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined...
  17. ncbi Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels
    Symi Richter
    Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA
    Diabetes 52:2989-95. 2003
    ..In this study, we show that Hnf-1alpha is a potent transcriptional activator of the gene encoding apolipoprotein M (apoM), a lipoprotein that is associated with the HDL particle...
  18. ncbi Expression pattern of apolipoprotein M during mouse and human embryogenesis
    Xiao Ying Zhang
    Laboratory of Molecular Medicine, The Third Affiliated Hospital, Suzhou University, Changzhou, China
    Acta Histochem 106:123-8. 2004
    b>Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportions in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL)...
  19. doi Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms
    Josefin Ahnström
    Wallenberg Laboratory, Department of Laboratory Medicine, Clinical Chemistry, Lund University, SE 205 02 Malmo, Sweden
    Clin Biochem 43:407-10. 2010
    ..The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA...
  20. doi Expression of apolipoprotein M in human hepatocellular carcinoma tissues
    Jingting Jiang
    Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Jiangsu Changzhou, China
    Acta Histochem 113:53-7. 2011
    The present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in the adjacent tissues...
  21. pmc Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY
    Jan Skupien
    Department and Chair of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
    Rev Diabet Stud 4:231-5. 2007
    b>Apolipoprotein M (apoM) is a 26-kDa protein expressed mainly in the liver and kidneys. It is present predominantly in high-density lipoproteins (HDL)...
  22. ncbi Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese
    Nifang Niu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, PR China
    Diabetes Metab Res Rev 23:21-5. 2007
    ..Recent studies have demonstrated that apolipoprotein M (apoM) is important for the formation of prebeta-high-density lipoprotein (HDL) and cholesterol (CHO) efflux ..
  23. ncbi Infection and inflammation decrease apolipoprotein M expression
    Kenneth R Feingold
    Department of Veterans Affairs Medical Center, Metabolism Section, SFVAMC, San Francisco, CA 94121, United States
    Atherosclerosis 199:19-26. 2008
    ..b>Apolipoprotein M is a recently described HDL-associated apoprotein expressed mainly in the liver and kidney with protective ..
  24. doi Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies
    Josefin Ahnström
    Department of Laboratory Medicine, Clinical Chemistry, University of Lund, University Hospital, Malmo, Sweden
    J Lipid Res 49:1912-7. 2008
    b>Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL...
  25. ncbi Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells
    Ning Xu
    Department of Clinical Chemistry, University Hospital of Lund, Lund, S 221 85, Sweden
    Biochem Biophys Res Commun 292:944-50. 2002
    b>Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL) in plasma, exclusively expressed in liver and in kidney. The function of apoM is yet unknown...
  26. ncbi Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells
    Guanghua Luo
    Laboratory of Molecular Medicine, The Third Affiliated Hospital, Suzhou University, Changzhou 213003, China
    Biochim Biophys Acta 1734:198-202. 2005
    b>Apolipoprotein M (apoM) is a novel apolipoprotein presented mostly in high-density lipoprotein (HDL) in human plasma. Previously we have reported that both leptin and leptin receptor are essential for apoM expression in vivo...
  27. ncbi Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization
    Xiao Ying Zhang
    Laboratory of Molecular Medicine, The Third Affiliated Hospital, Suzhou University, Changzhou, China
    Acta Histochem 105:67-72. 2003
    b>Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL)...
  28. ncbi Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M
    Josefin Ahnström
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, SE 20502 Malmo, Sweden
    J Lipid Res 48:1754-62. 2007
    b>Apolipoprotein M (apoM) is a plasma protein associated mainly with HDL. ApoM is suggested to be important for the formation of prebeta-HDL, but its mechanism of action is unknown. Homology modeling has suggested apoM to be a lipocalin...
  29. doi The identification of apolipoprotein genes in rare minnow (Gobiocypris rarus) and their expression following perfluorooctanoic acid exposure
    Xuemei Fang
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China
    Comp Biochem Physiol C Toxicol Pharmacol 151:152-9. 2010
    ..Therefore, subacute exposure to PFOA resulted in alteration of expression of apolipoproteins and related genes. These changes in gene expression may further influence lipid metabolism or other physiological functions in fish...
  30. ncbi Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cells
    Ning Xu
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, Klinikgatan 19, S 221 85 Lund, Sweden
    Biochim Biophys Acta 1683:33-7. 2004
    b>Apolipoprotein M (apoM) is a novel apolipoprotein presented mostly in high-density lipoprotein (HDL) in human plasma, and is exclusively expressed in liver and in kidney. The pathophysiological function of apoM has not yet been elucidated...
  31. ncbi Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray
    Yuefang Liu
    Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 210029, PR China
    Oncol Rep 18:943-51. 2007
    ..Further characterization of these differentially expressed genes will provide information useful in understanding the genes responsible for the development of HCC...
  32. doi Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men
    Esther M M Ooi
    Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia
    Atherosclerosis 210:326-30. 2010
    ..The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men...
  33. ncbi Vaccinia virus-expressed bovine ephemeral fever virus G but not G(NS) glycoprotein induces neutralizing antibodies and protects against experimental infection
    C Hertig
    CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Gen Virol 77:631-40. 1996
    ..G protein but reacted with monoclonal antibodies directed against all defined neutralizing antigenic sites (G1, G2, G3a, G3b and G4). The recombinant G(NS) protein (mol...
  34. pmc Determination of single-nucleotide polymorphism in the proximal promoter region of apolipoprotein M gene in coronary artery diseases
    Lu Zheng
    Comprehensive Laboratory, The Third Affiliated Hospital, Suzhou University, Changzhou China
    Int J Gen Med 2:177-82. 2009
    It has been reported that single-nucleotide polymorphism (SNP) in the proximal promoter region of apolipoprotein M (apoM) gene may confer the risk in the development of type 2 diabetes (T2D) and coronary artery disease (CAD) in the Han ..
  35. doi Isolation and characterization of the apolipoprotein multigene family in Hemibarbus mylodon (Teleostei: Cypriniformes)
    Keun Yong Kim
    Department of Aquaculture, Pukyong National University, Nam Gu, Busan 608 737, South Korea
    Comp Biochem Physiol B Biochem Mol Biol 152:38-46. 2009
    ..mylodon than in other teleosts and mammals. In addition, our findings showed the multiple isoforms of apoA-I and apoE were differentially modulated across tissues possibly with an isoform-specific role in a given tissue...
  36. ncbi Location of neutralizing epitopes on the G protein of bovine ephemeral fever rhabdovirus
    K Kongsuwan
    CSIRO Tropical Agriculture, Long Pocket Laboratories, Indooroopilly, QLD, Australia
    J Gen Virol 79:2573-81. 1998
    ..Site G2 mutations mapped either at aa 169 or 187. The 12 mutants representing antigenic site G3 (G3a and G3b) mapped to aa 49, 57, 218, 229 and 265, indicating that this site is likely to combine complex ..
  37. ncbi Suppression of apolipoprotein M expression and secretion in alloxan-diabetic mouse: Partial reversal by insulin
    Ning Xu
    Division of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lund University, Lund, S 221 85 Lund, Sweden
    Biochem Biophys Res Commun 342:1174-7. 2006
    We previously reported that apolipoprotein M (apoM) expression is reduced in ob/ob mice. Whether such a reduction is specific for this model or is a more general phenomenon in diabetes models is not known...
  38. ncbi Remote sensing of aerosol plumes: a semianalytical model
    Alexandre Alakian
    Commissariat a l Energie Atomique, BP 12, 91680 Bruyères le Châtel, France
    Appl Opt 47:1851-66. 2008
    ..This model can be used for forward modeling (quick simulations of multi/hyperspectral images and help in sensor design) as well as for the retrieval of the plume optical properties from remotely sensed images...
  39. doi Genotyping of single nucleotide polymorphisms using base-quenched probe: a method does not invariably depend on the deoxyguanosine nucleotide
    Guanghua Luo
    Comprehensive Laboratory, Third Affiliated Hospital, Suzhou University, Changzhou 213003, China
    Anal Biochem 386:161-6. 2009
    ..For describing the method in detail, we chose apolipoprotein M (apoM) as a target gene in the current study...
  40. ncbi [Association analysis between SNPs of the growth hormone receptor gene and growth traits in arctic fox]
    Zhi Heng DU
    Department of Animal Science, Northeast Agriculture University, Harbin 150030, China
    Yi Chuan 32:599-605. 2010
    ..Four SNPs, G3A in the 5'UTR, C99T in the first exon, T59C and G65A in the fifth exon were identified on the arctic fox GHR gene...
  41. doi Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins
    Hung Yu Sun
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Clin Chim Acta 411:336-44. 2010
    ..Low-density lipoprotein (LDL) is a natural metabolite of very-low-density lipoprotein (VLDL) in the circulation. Systematic investigation of total protein components and dynamics might provide insights into this normal metabolic process...
  42. doi Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold?
    Madhumati Sevvana
    Lehrstuhl für Biotechnik, Department Biologie, Friedrich Alexander Universitat Erlangen Nurnberg, Im IZMP, Henkestr 91, D 91052 Erlangen, Germany
    J Mol Biol 404:363-71. 2010
    Mouse apolipoprotein M (m-apoM) displays a 79% sequence identity to human apolipoprotein M (h-apoM). Both proteins are apolipoproteins associated with high-density lipoproteins, with similar anticipated biological functions...
  43. ncbi Down-regulation of apolipoprotein M expression is mediated by phosphatidylinositol 3-kinase in HepG2 cells
    Ning Xu
    Section of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lunds University, S 221 85 Lund, Sweden
    Biochim Biophys Acta 1761:256-60. 2006
    b>Apolipoprotein M (apoM) is a novel apolipoprotein present mostly in high-density lipoprotein (HDL) in human plasma...
  44. doi Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitro
    Xiaoying Zhang
    Comprehensive Laboratory, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, China
    Biochem Biophys Res Commun 371:114-7. 2008
    It has been demonstrated that apolipoprotein M (apoM), a recently discovered HDL apolipoprotein, has antiatherosclerotic properties, which may be mediated by the enhancement of reversed cholesterol transportation and/or hepatic ..
  45. doi An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA
    C Cervin
    Department of Clinical Sciences, Diabetes and Endocrinology, Clinical Research Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    J Intern Med 267:316-21. 2010
    To investigate the fitness of serum apolipoprotein M (apoM) concentration as a marker for maturity-onset diabetes of the young 3 (MODY3).
  46. ncbi Apolipoprotein M likely extends its anti-atherogenesis via anti-inflammation
    Xian sheng Huang
    Department of Cardiology, The Second Xiangya Hospital of Central South University, No 139, Renmin Zhonglu, Changsha, Hunan 410011, PR China
    Med Hypotheses 69:136-40. 2007
    b>Apolipoprotein M (apoM), a novel human apolipoprotein recently discovered, predominantly presents in high density lipoprotein (HDL) in plasma, exclusively expressed in liver and in kidney...
  47. ncbi Hyperglycemia down-regulates apolipoprotein M expression in vivo and in vitro
    Xiaoying Zhang
    Comprehensive Laboratory, The Third Affiliated Hospital, Suzhou University, Changzhou 213003, China
    Biochim Biophys Acta 1771:879-82. 2007
    ..However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly...
  48. doi Molecular characterization, expression profile and association analysis with fat deposition traits of the porcine APOM gene
    Gang Pan
    Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, China
    Mol Biol Rep 37:1363-71. 2010
    b>Apolipoprotein M (APOM), a novel apolipoprotein presented mostly in high-density lipoprotein (HDL) in plasma, is involved in lipid and lipoprotein metabolism. Through comparative mapping, we have mapped this gene to SSC7 p1...
  49. doi Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes
    Yan wei Hu
    Laboratory Medicine Center, Nangfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
    Biochim Biophys Acta 1801:100-5. 2010
    b>Apolipoprotein M (apoM) is a novel apolipoprotein belonging to the lipocalin protein superfamily...
  50. ncbi Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo
    Ning Xu
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S 221 85 Lund, Sweden
    Biochem Biophys Res Commun 321:916-21. 2004
    It was previously shown that circulating levels of leptin and apolipoprotein M (apoM) correlate to each other. In this study, we examined whether plasma leptin and leptin-receptors are of importance for apoM expression in vivo...
  51. doi Effects of laser photobiomodulation on cutaneous wounds treated with mitomycin C: a histomorphometric and histological study in a rodent model
    Nicole R Silva Santos
    Laser Center, School of Dentistry, Federal University of Bahia, Salvador, Brazil
    Photomed Laser Surg 28:81-90. 2010
    ..The aim of the present study was to assess histologically the effect of Laser Photobiomodulation (LPBM) on skin wounds treated with Mitomycin C (MMC)...
  52. doi Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus
    Paul J W H Kappelle
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Atherosclerosis 213:247-50. 2010
    Plasma apolipoprotein M (apoM) is potentially anti-atherogenic, and has been found to be associated positively with plasma total, LDL and HDL cholesterol in humans. ApoM may, therefore, be intricately related to cholesterol metabolism...
  53. ncbi Candidate genes for quantitative resistance to Mycosphaerella pinodes in pea (Pisum sativum L.)
    S Prioul-Gervais
    UMR INRA Agrocampus Rennes, Amelioration des Plantes et Biotechnologies Vegetales, Domaine de la Motte au Vicomte, BP 35327, 35653, Le Rheu Cedex, France
    Theor Appl Genet 114:971-84. 2007
    ..Out of the 16 sequences studied, the two RGAs RGA-G3A and RGA2...
  54. ncbi Adrenocorticotrophic hormone retarded metabolism of low-density lipoprotein in rats
    N Xu
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, Sweden
    Scand J Clin Lab Invest 64:217-22. 2004
    ..This study clearly demonstrates that ACTH has species specificity differences in humans and in the rat...
  55. pmc Evolution and comparative analysis of the MHC Class III inflammatory region
    Janine E Deakin
    ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    BMC Genomics 7:281. 2006
    ..We also discuss the extent of sequence conservation across the entire region and identify elements conserved in evolution...
  56. doi Association of the apolipoprotein M gene polymorphisms and serum lipid levels
    Lynn Htet Htet Aung
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People s Republic of China
    Mol Biol Rep 40:1843-53. 2013
    The association of rs707921 and rs707922 SNPs in the apolipoprotein M (APOM) gene and serum lipid levels is still controversial...
  57. pmc The 5'UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins
    Raghavendran Kulasegaran-Shylini
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
    Virology 387:211-21. 2009
    ..Its attenuated phenotype was shown to rely only on two point mutations, one of which, G3A, was found in the 5' untranslated region (5'UTR) of the viral genome...
  58. ncbi The APOM polymorphism as a novel risk factor for dyslipidaemia in rheumatoid arthritis: a possible shared link between disease susceptibility and dyslipidaemia
    Yune Jung Park
    Department of Internal Medicine, The Catholic University of Korea, Korea
    Clin Exp Rheumatol 31:180-8. 2013
    ..b>Apolipoprotein M (apoM) is an apolipoprotein predominantly associated with HDL cholesterol...
  59. ncbi [Randomized clinical trial: effectiveness of the cognitive-behavioral approach and the use of nicotine replacement transdermal patches for smoking cessation among adults in Rio de Janeiro, Brazil]
    Ubirani Barros Otero
    Coordenação de Prevenção e Vigilância, Instituto Nacional de Cancer, Rua dos Inválidos 212, 2o andar, Rio de Janeiro, RJ 20231 020, Brazil
    Cad Saude Publica 22:439-49. 2006
    ..were 20% (GB), 17% (G1-G2), and 23% (G3-G4); and among assigned NRT groups were 30% (GBA), 34% (G1A-G2A), and 33% (G3A-G4A)...
  60. pmc Dihydrotestosterone regulating apolipoprotein M expression mediates via protein kinase C in HepG2 cells
    Ye Yi-Zhou
    Department of Cardiovascular Surgery, Affiliated Shanghai 1st People s Hospital, Shanghai Jiaotong University, Shanghai 210008, People s Republic of China
    Lipids Health Dis 11:168. 2012
    ..This present study used HepG2 cell cultures and ovariectomized C57BL/6 J mice to determine whether apolipoprotein M (ApoM), a constituent of HDL, was affected by dihydrotestosterone (DHT).
  61. pmc The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Lipid Res 53:2198-204. 2012
    ..38, P = 0.009). These data suggest that the plasma clearance of apoM, despite apoM primarily being associated with HDL, is influenced by LDL receptor-mediated clearance of apoB-containing particles...
  62. pmc Uptake of gold nanoparticles in several rat organs after intraperitoneal administration in vivo: a fluorescence study
    Mohamed Anwar K Abdelhalim
    Department of Physics and Astronomy, College of Science, King Saud University, P O Box 2455, Riyadh 11451, Saudi Arabia
    Biomed Res Int 2013:353695. 2013
    ..In an attempt to characterise the potential toxicity or hazards of GNPs as a therapeutic or diagnostic tool, the fluorescence spectra in several rat organs in vivo were measured after intraperitoneal administration of GNPs...
  63. ncbi Epidemiological analysis of outcomes in 323 open tibial diaphyseal fractures: a nine-year experience
    Weiliang Chua
    Department of Orthopaedic Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Singapore Med J 53:385-9. 2012
    ..Open fractures of the tibia pose a challenge to orthopaedic and plastic surgeons. A retrospective observational review was conducted to evaluate the epidemiological factors and fracture outcomes in the Singapore context...
  64. doi Anti-inflammatory effects of propofol are mediated by apolipoprotein M in a hepatocyte nuclear factor-1α-dependent manner
    Xin Ma
    Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
    Arch Biochem Biophys 533:1-10. 2013
    ..At the same time, the expression of hepatocyte nuclear factor-1α (HNF-1α) and apolipoprotein M (APOM) was inhibited by treatment with LPS and LPS-induced down-regulation of HNF-1α expression and APOM ..
  65. ncbi Predominance of G3B and G14 equine group A rotaviruses of a single VP4 serotype in Japan
    H Tsunemitsu
    Shichinohe Research Unit, National Institute of Animal Health, Aomori, Japan
    Arch Virol 146:1949-62. 2001
    ..There were five differing amino acid residues in three VP7 antigenic regions between subtypes G3A and G3B...
  66. doi Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M
    Makoto Kurano
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Atherosclerosis 229:102-9. 2013
    ..Since S1P riding on HDL was recently shown to bind to apolipoprotein M (apoM), which is derived from liver, we analyzed the possible involvement of liver in S1P metabolism.
  67. doi Antigenic characterization of bovine ephemeral fever rhabdovirus G and GNS glycoproteins expressed from recombinant baculoviruses
    Jasjit Johal
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 308 Carmody Road, St Lucia, QLD 4072, Australia
    Arch Virol 153:1657-65. 2008
    ..MAbs to continuous and conformational neutralization sites (G1, G2, G3b and G4), but not to conformational site G3a. The expressed G(NS) protein was also located on the cell surface but did not exhibit fusogenic activity...
  68. pmc Enchanced levels of apolipoprotein M during HBV infection feedback suppresses HBV replication
    Jin Gang Gu
    Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, PR China
    Lipids Health Dis 10:154. 2011
    ..Hepatitis B virus (HBV) is a major etiological agent causing acute and chronic liver diseases. Apolipoprotein M (ApoM) is a high-density lipoprotein (HDL) apolipoprotein and exclusively expressed in the liver parenchyma ..
  69. pmc Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes
    Sunil B Kumaraswamy
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital, Entrance 46, Malmo, SE 20502, Sweden
    Crit Care 16:R60. 2012
    b>Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection...
  70. doi Vascular endothelial growth factor downregulates apolipoprotein M expression by inhibiting Foxa2 in a Nur77-dependent manner
    Yan wei Hu
    Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
    Rejuvenation Res 15:423-34. 2012
    We aimed to investigate whether vascular endothelial growth factor (VEGF) influences apolipoprotein M (ApoM) expression and pre-β-high-density lipoprotin (HDL) formation, and whether forkhead box A2 (Foxa2) and Nur77 are involved in this ..
  71. doi ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells
    Dongmei DI
    Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, PR China
    Biochem Biophys Res Commun 421:152-6. 2012
    We have previously reported that liver X receptor (LXR) agonist, TO901317, could significantly inhibit hepatic apolipoprotein M (apoM) expression...
  72. pmc Recombinant influenza A viruses with enhanced levels of PB1 and PA viral protein expression
    Alan Belicha-Villanueva
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Virol 86:5926-30. 2012
    Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species...
  73. ncbi Serum SP-D levels as a biomarker of lung injury in children suffering of bronchopneumonia
    Amira A Abd El Rahman Mosbah
    Department of Pediatric Medicine, Faculty of Medicine, Cancer Institute, Cairo University, Cairo, Egypt
    J Egypt Soc Parasitol 42:25-32. 2012
    ..We evaluated baseline characteristics, clinical features, and serum SP-D concentration in G1, G2, and G3a (healthy control cross-matched infants)...
  74. pmc Attenuated influenza virus construct with enhanced hemagglutinin protein expression
    Jad Maamary
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Virol 86:5782-90. 2012
    ..For this purpose, we generated an NS1-truncated recombinant influenza A/Puerto Rico/8/34 (rPR8) virus carrying the G3A C8U "superpromoter" mutations in the HA genomic RNA segment...
  75. ncbi HDL stimulates apoM secretion
    Josefin Ahnström
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, SE 20502 Malmo, Sweden
    Protein Pept Lett 17:1285-9. 2010
    b>Apolipoprotein M (apoM) in human plasma is mainly associated with HDL. A retained signal peptide anchors apoM to the lipoproteins...
  76. pmc Regulation of human apolipoprotein m gene expression by orphan and ligand-dependent nuclear receptors
    Ioanna Mosialou
    Department of Biochemistry, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, Heraklion 71003, Greece
    J Biol Chem 285:30719-30. 2010
    b>Apolipoprotein M (apoM) plays an important role in the biogenesis and the metabolism of anti-atherogenic HDL particles in plasma and is expressed primarily in the liver and the kidney...
  77. doi Plasma levels of apolipoprotein M in normal and complicated pregnancy
    Josefin Ahnström
    Department of Laboratory Medicine, University Hospital, Lund University, Malmo, Sweden
    Acta Obstet Gynecol Scand 89:1214-7. 2010
    b>Apolipoprotein M (apoM) is mainly associated with high-density lipoprotein in human plasma. Despite several studies suggesting apoM as an anti-atherogenic, its function is not yet fully understood...
  78. doi Hydrophilic interaction chromatography of intact, soluble proteins
    Tim Tetaz
    F Hoffmann La Roche Ltd, Discovery Technologies, PROBMX21, Basel, Switzerland
    J Chromatogr A 1218:5892-6. 2011
    ..Five different commercially available HILIC columns were compared. Using one of these columns, different glycosylated isoforms of apoM were separated from each other and from the aglyco-form...
  79. ncbi Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects
    Paul J W H Kappelle
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Atherosclerosis 214:492-4. 2011
    b>Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing...
  80. doi Effect of simvastatin on the expression and regulation mechanism of apolipoprotein M
    Liu Yang
    Department of Cadres Medical, Xiangya Hospital, Central South University, Changsha 410011, P R China
    Int J Mol Med 29:510-4. 2012
    b>Apolipoprotein M (ApoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL) in the plasma. Statins have effects on many HDL-associated apolipoproteins...
  81. pmc Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis
    Hae Jin Hu
    Integrated Research Center for Genome Polymorphism, The Catholic University of Korea School of Medicine Seoul 137 701, Korea
    Exp Mol Med 43:613-21. 2011
    ..These results indicate that APOM promoter polymorphisms are significantly associated with the susceptibility to RA...
  82. ncbi Clinical significance of serum apolipoprotein M level
    Shinobu Tanaka
    Central Clinical Laboratory, Nara Medical University Hospital, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Clin Lab 57:803-6. 2011
    ..However, further evaluation of the clinical significance of apoM might be needed...
  83. pmc Expression and localization of apolipoprotein M in human colorectal tissues
    Guanghua Luo
    Comprehensive Laboratory, Third Affiliated Hospital, Suzhou University, Changzhou, China
    Lipids Health Dis 9:102. 2010
    It has been well documented that apolipoprotein M (apoM) is principally expressed in the liver and kidney. However we found that there was weak apoM expression in other tissues or organs too, which could not be ignored...
  84. doi Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Circ Res 106:1624-34. 2010
    ..HDL-bound apoM is antiatherogenic in vitro. However, plasma apoM is not associated with coronary heart disease in humans, perhaps because of a positive correlation with plasma low-density lipoprotein (LDL)...
  85. doi The periodontal pathogen Porphyromonas gingivalis cleaves apoB-100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation
    T Bengtsson
    Division of Pharmacology, Department of Medical and Health Sciences, Faculty of Health Sciences, Cardiovascular Inflammation Research Centre, Linkoping University, Linkoping, Sweden
    J Intern Med 263:558-71. 2008
    ..This study aims at investigating the proteolytic and oxidative activity of P. gingivalis on LDL in a whole blood system using a proteomic approach and analysing the effects of P. gingivalis-modified LDL on cell proliferation...
  86. ncbi Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 283:1839-47. 2008
    ..The effect of apoM on atherosclerosis may be facilitated by enzymatic modulation of plasma HDL particles, increased cholesterol efflux from foam cells, and an antioxidative effect of apoM-containing HDL...
  87. ncbi A genetic variant of apolipoprotein M increases susceptibility to coronary artery disease in a Chinese population
    Wei Wei Xu
    Atherosclerosis Research Center, Nanjing Medical University, Nanjing, China
    Clin Exp Pharmacol Physiol 35:546-51. 2008
    ..819, 95% confidence interval 1.142-2.898; P = 0.012). 4. In conclusion, the results of the present study suggest that the APOM T-855C polymorphism carries an increased risk for CAD in this Chinese population...
  88. ncbi An ELISA for apolipoprotein M reveals a strong correlation to total cholesterol in human plasma
    Olof Axler
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital Malmo, SE 20502 Malmo, Sweden
    J Lipid Res 48:1772-80. 2007
    b>Apolipoprotein M (apoM) is a 188 amino acid, 25 kDa protein belonging to the lipocalin protein superfamily. Although predominantly associated with high density lipoprotein, apoM is found in all major lipoprotein classes...
  89. ncbi Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF
    Carmine Mancone
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    Proteomics 7:143-54. 2007
    ..While the physiological relevance of our finding remains to be assessed, we believe that our results will be useful as reference for future studies of VLDL structure in specific physiopathological conditions...
  90. ncbi Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver
    X Xu
    Research Institute of Organ Transplantation, The Affiliated TongJi Hospital of Huazhong University of Science and Technology, Wuhan, China
    Transplant Proc 38:2769-73. 2006
    The present study investigated the expression pattern of apolipoprotein M (apoM) mRNA in a rat model of hepatic ischemia-reperfusion injury (IRI). Animals were ischemic for 1 hour followed by various reperfusion times...
  91. ncbi Apolipoprotein M: progress in understanding its regulation and metabolic functions
    C Christoffersen
    Department of Clinical Biochemistry, Rigshospital, University of Copenhagen, Copenhagen, Denmark
    Scand J Clin Lab Invest 66:631-7. 2006
    ..Further studies of mice with genetically modified apoM expression will be essential to unravel the potential roles of apoM in lipoprotein metabolism, atherosclerosis and kidney biology...
  92. ncbi Evaluation of a Burdizzo castrator for neutering of dogs
    A Ortega-Pacheco
    Faculty of Veterinary Medicine and Animal Science, Autonomous University of Yucatan, Yucatan, Mexico
    Reprod Domest Anim 41:227-32. 2006
    ..There was a control group (G1), a surgically castrated group (G2) and a Burdizzo group (G3) divided in two, G3a receiving two crunches in each spermatic cord and G3b receiving one crunch in each spermatic cord...
  93. ncbi Isolation and characterization of human apolipoprotein M-containing lipoproteins
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospital, University of Copenhagen, Copenhagen DK 2100, Denmark
    J Lipid Res 47:1833-43. 2006
    b>Apolipoprotein M (apoM) is a novel apolipoprotein with unknown function. In this study, we established a method for isolating apoM-containing lipoproteins and studied their composition and the effect of apoM on HDL function...
  94. ncbi Genetic variants predisposing to cardiovascular disease
    Sophie Visvikis-Siest
    INSERM U525 Equipe 4, Faculty of Pharmacy, Nancy, France
    Curr Opin Lipidol 17:139-51. 2006
    ..In addition, emphasis will be placed on the methodological problems associated with studying the genetics of complex disorders, specifically cardiovascular diseases...
  95. ncbi Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M
    Kirsten Faber
    Department of Clinical Biochemistry, Univeristy of Lund, University Hospital, Malmo, Sweden
    Mol Endocrinol 20:212-8. 2006
    ..The results suggest that apoM binds to megalin and that megalin-mediated endocytosis in kidney proximal tubules prevents apoM excretion in the urine...
  96. ncbi Characterization of apoM in normal and genetically modified mice
    Kirsten Faber
    Division of Clinical Chemistry, Department of Laboratory Medicine, University of Lund, University Hospital Malmo, S 20502 Malmo, Sweden
    J Lipid Res 45:1272-8. 2004
    A novel human apolipoprotein [apolipoprotein M (apoM)] was recently described and demonstrated to be a lipocalin. We have now examined apoM in wild-type mice and mice with genetically altered lipoprotein metabolism...
  97. doi Apolipoprotein M associates to lipoproteins through its retained signal peptide
    Olof Axler
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    FEBS Lett 582:826-8. 2008
    b>Apolipoprotein M (apoM) is predominantly associated with HDL. In this study, it was investigated whether apoM's uncleaved signal peptide is necessary for the protein's ability to associate with lipoproteins...
  98. doi Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury
    Fatih S Erol
    Department of Neurosurgery, School of Medicine, Firat University, Elazig 23200, Turkey
    J Clin Neurosci 15:784-90. 2008
    ..Louis, MO, USA) immediately after laminectomy, then the same dose again on the day following injury (G3a), or given three equal doses over 10 days to achieve a total dose of 7.5 mg/kg/day (G3b)...
  99. ncbi LXR-agonists regulate ApoM expression differentially in liver and intestine
    Emine Calayir
    Institute of Molecular Biology and Biochemistry, Ctr for Molecular Medicine, Medical University of Graz, Austria
    Curr Pharm Biotechnol 9:516-21. 2008
    b>Apolipoprotein M (apoM) has been suggested to play a role in reverse cholesterol transport. Here we studied the influence of liver X-receptor (LXR) agonist on the transcriptional regulation of apoM...
  100. doi Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?
    B Dahlback
    Department of Laboratory Medicine, University Hospital, University of Lund, Malmo, Sweden
    Cell Mol Life Sci 66:559-64. 2009
    b>Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin ss-barrel fold and a hydrophobic pocket...
  101. doi Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects
    P Plomgaard
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Intern Med 266:258-67. 2009
    ..Herein, we examined whether patients with type 2 diabetes have reduced plasma apoM and whether apoM is associated with pre-beta-HDL formation and cellular cholesterol efflux...

Research Grants6

  1. COORDINATE CONTROL OF HUMAN HLA-D REGION AND II GENES
    Jenny Ting; Fiscal Year: 2000
    ..Finally, identification of the basic defect in G3A, which leads to the lack of CIITA induction by IFN-gamma will be identified by complementation cloning.
  2. UV RESONANCE RAMAN STUDIES OF PROTEIN STRUCTURE
    Sanford Asher; Fiscal Year: 2001
    ..We will improve UV Raman instrumentation, to increase its sensitivity. ..