ApoE

Summary

Gene Symbol: ApoE
Description: apolipoprotein E
Alias: AD2, LDLCQ5, LPG, apo-E, apolipoprotein E3
Species: human

Top Publications

  1. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
  2. ncbi Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
  3. doi Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
  4. ncbi Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
  5. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
  6. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
  7. pmc Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele
    Nicola Filippini
    University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7209-14. 2009
  8. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
  9. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
  10. ncbi Apolipoprotein E: far more than a lipid transport protein
    R W Mahley
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
    Annu Rev Genomics Hum Genet 1:507-37. 2000

Detail Information

Publications279 found, 100 shown here

  1. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
    ..In addition to identifying the epsilon4 allele of APOE and related effects, we pinpointed over a dozen potential Alzheimer disease susceptibility genes (ACE, CHRNB2, CST3,..
  2. ncbi Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
    ..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
  3. doi Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
    b>APOE epsilon4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD)...
  4. ncbi Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
    The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD)...
  5. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1...
  6. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease...
  7. pmc Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele
    Nicola Filippini
    University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7209-14. 2009
    The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects...
  8. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  9. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
    The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD)...
  10. ncbi Apolipoprotein E: far more than a lipid transport protein
    R W Mahley
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
    Annu Rev Genomics Hum Genet 1:507-37. 2000
    ..b>ApoE is a polymorphic protein arising from three alleles at a single gene locus...
  11. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
    With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown.
  12. ncbi A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
    Keith D Coon
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz 85004, USA
    J Clin Psychiatry 68:613-8. 2007
    While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19...
  13. ncbi Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study
    Laura Jean Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 161:639-51. 2005
    ..79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers...
  14. pmc ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
    Ying Chen
    Department of Molecular Genetics, Center for Alzheimer s and Neurodegenerative Disease, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 107:12011-6. 2010
    Apolipoprotein E (ApoE) genotype is a powerful genetic modifier of Alzheimer's disease (AD). The ApoE4 isoform significantly reduces the mean age-of-onset of dementia through unknown mechanisms...
  15. pmc Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
    Eric M Reiman
    Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Proc Natl Acad Sci U S A 101:284-9. 2004
    ..Carriers of a common Alzheimer's susceptibility gene have functional brain abnormalities in young adulthood, several decades before the possible onset of dementia...
  16. pmc fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Mark W Bondi
    University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Neurology 64:501-8. 2005
    To determine whether APOE genotype influences brain response and whether nonverbal stimuli generate findings comparable with those of previous studies that used verbal stimuli...
  17. pmc Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study
    Mi Ryung Han
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Neurol 10:90. 2010
    ..common and highly heritable with many genes and gene variants associated with AD in one or more studies, including APOE ε2/ε3/ε4...
  18. doi The effects of APOE on the functional architecture of the resting brain
    Aaron J Trachtenberg
    Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, University of Oxford, Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom
    Neuroimage 59:565-72. 2012
    There is a well-established association between APOE genotype and the risk of developing Alzheimer's disease (AD)...
  19. pmc Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    S Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
    Neurology 76:69-79. 2011
    ..We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42)...
  20. pmc APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
    Yvette I Sheline
    Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:17035-40. 2010
    ....
  21. pmc Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
    Faith M Harris
    Gladstone Institute of Neurological Disease, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 100:10966-71. 2003
    ..However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation of ..
  22. pmc The role of apolipoprotein E in Alzheimer's disease
    Jungsu Kim
    Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 63:287-303. 2009
    The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD)...
  23. ncbi The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration
    Paul N Baird
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:1311-5. 2004
    ..of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease...
  24. doi Differential effects of the APOE genotype on brain function across the lifespan
    N Filippini
    University Department of Psychiatry, University of Oxford, Oxford, UK
    Neuroimage 54:602-10. 2011
    Increasing age and carrying an APOE ε4 allele are well established risk factors for Alzheimer's disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an accelerated aging process...
  25. ncbi Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    P M Sullivan
    Department of Pathology and Laboratory of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 272:17972-80. 1997
    ..The levels of apoE mRNA in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and their littermates ..
  26. doi Examination of the current top candidate genes for AD in a genome-wide association study
    T M Feulner
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
    Mol Psychiatry 15:756-66. 2010
    ..Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD...
  27. pmc ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo
    Sonya B Dumanis
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 29:15317-22. 2009
    The three human alleles of apolipoprotein E (APOE) differentially influence outcome after CNS injury and affect one's risk of developing Alzheimer's disease (AD)...
  28. ncbi Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    R W Mahley
    Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
    Science 240:622-30. 1988
    ..Other functions of apolipoprotein E, unrelated to lipid transport, are becoming known, including immunoregulation and modulation of cell growth and differentiation...
  29. pmc Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    David G Cook
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Pathol 162:313-9. 2003
    ..shown that AD patients exhibit abnormalities in insulin metabolism that are associated with apoliprotein E (APOE) status...
  30. ncbi MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET
    L Mosconi
    Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Neurology 63:2332-40. 2004
    To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD).
  31. ncbi Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age
    Eloise Kok
    Department of Forensic Medicine, Medical School, University of Tampere, Tampere, Finland
    Ann Neurol 65:650-7. 2009
    ..age dependency of senile plaques (SP) and neurofibrillary tangles (NFT), the brain changes characteristic of Alzheimer disease (AD), and their association with apolipoprotein E (APOE) genotypes in a community-dwelling normal population.
  32. pmc Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers
    A C Burggren
    David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, 760 Westwood Plaza B8 169, Los Angeles, CA 90095, USA
    Neuroimage 41:1177-83. 2008
    Our objective was to investigate whether asymptomatic carriers of apolipoprotein E epsilon4 [APOE-4] demonstrate pathological differences and atrophy in medial temporal lobe (MTL) subregions...
  33. pmc Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate
    Jieyun Jiang
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Virol 86:7256-67. 2012
    ..substantial evidence demonstrating that hepatitis C virus (HCV) uses the cellular protein apolipoprotein E (apoE) for its attachment to cells...
  34. pmc Amyloid load in nondemented brains correlates with APOE e4
    Richard J Caselli
    Department of Neurology, Mayo Clinic Arizona, 13400 East Shea Blvd, Scottsdale, AZ 85259, United States
    Neurosci Lett 473:168-71. 2010
    ..and neurofibrillary tangle (NFT) density scores were based on CERAD criteria and compared in apolipoprotein E (APOE) e4 carriers (n=42) and noncarriers (NC) (n=137). Mean age (83.4+/-...
  35. pmc Multilocus analysis of age-related macular degeneration
    Julie Bergeron-Sawitzke
    SAIC Frederick, Basic Science Program, Human Genetics Section, Frederick, MD 21702 1201, USA
    Eur J Hum Genet 17:1190-9. 2009
    ..B (CFB), age-related maculopathy susceptibility (ARMS2), HtrA serine peptidase 1 (HTRA1), and apolipoprotein E (APOE)...
  36. doi The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers
    Min Wang
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China
    Neurosci Lett 482:260-3. 2010
    ..Definitive genotyping of these markers and apolipoprotein E (APOE) polymorphism were surveyed in 341 SAD patients and 421 controls...
  37. pmc Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Hum Genet 57:18-25. 2012
    Genetic variation within the apolipoprotein E gene (APOE) locus is associated with late-onset Alzheimer's disease risk and quantitative traits as well as apoE expression in multiple tissues...
  38. doi Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
    Tanja Richter-Schmidinger
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neural Transm 118:249-57. 2011
    Unravelling the impact of genetic variants on clinical phenotypes is a challenging task. Apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) play an important role in cell growth, regeneration, synaptic plasticity, ..
  39. ncbi An association study of 43 SNPs in 16 candidate genes with atorvastatin response
    J F Thompson
    Discovery Pharmacogenomics, Pfizer Global Research and Development, Eastern Point Road, MS8118D 3069, Groton, CT 06340, USA
    Pharmacogenomics J 5:352-8. 2005
    ..The magnitude of all the differences found is sufficiently small that genetic data from these genes should not influence clinical decisions on statin administration...
  40. ncbi Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseases
    Shajith Anoop
    Department of Environmental Sciences, Bharathiar University, Coimbatore, India
    Indian J Med Res 132:363-78. 2010
    The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E)...
  41. ncbi Apolipoprotein E polymorphism--a risk factor for metabolic syndrome
    Anca Sima
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Clin Chem Lab Med 45:1149-53. 2007
    ..The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications.
  42. pmc APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population
    Rafael O Alvim
    Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    Lipids Health Dis 9:128. 2010
    ..The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population...
  43. ncbi APOE gene polymorphisms and response to statin therapy
    E Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Pharmacogenomics J 9:248-57. 2009
    Published studies investigating the role of APOE gene on lipid response (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides) to statin treatment have ..
  44. pmc Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci
    Joseph H Lee
    Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 65:1518-26. 2008
    ..To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD)...
  45. pmc Semantic memory activation in individuals at risk for developing Alzheimer disease
    M Seidenberg
    Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
    Neurology 73:612-20. 2009
    ..event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names.
  46. doi Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
    P J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    J Med Genet 46:300-7. 2009
    ..This paper examines other AMD susceptibility genes to determine if these genotypes influenced disease progression and treatment response...
  47. doi The APOE ɛ4 allele modulates brain white matter integrity in healthy adults
    V Heise
    Department of Psychiatry, University of Oxford, Oxford, UK
    Mol Psychiatry 16:908-16. 2011
    The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly ..
  48. ncbi Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele
    Heather A Wishart
    Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Am J Psychiatry 163:1603-10. 2006
    ..The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults.
  49. doi Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history
    Dan T A Eisenberg
    Department of Anthropology, Northwestern University, Evanston, IL 60208, USA
    Am J Phys Anthropol 143:100-11. 2010
    The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with increased cholesterol levels and heart disease...
  50. doi Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Polish Academy of Sciences Medical Research Center, 5 Pawinskiego Street, 02 106 Warsaw, Poland
    Neurobiol Aging 30:1749-55. 2009
    ..We conclude that further analysis of subtypes of haplogroup H would be necessary to decipher the relation of HV cluster with AD...
  51. pmc Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers
    Nancy A Dennis
    Center for Cognitive Neuroscience, Duke University, Durham, NC, USA
    Alzheimers Dement 6:303-11. 2010
    We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults.
  52. ncbi Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?
    J Persson
    Department of Psychology, Umea University, S 901 87 Umea, Sweden
    Neurology 66:1029-33. 2006
    Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly...
  53. pmc Brain network local interconnectivity loss in aging APOE-4 allele carriers
    Jesse A Brown
    Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:20760-5. 2011
    Old age and possession of the APOE-4 allele are the two main risk factors for developing later onset Alzheimer's Disease (AD)...
  54. ncbi Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine
    Clare A Peters-Libeu
    Gladstone Institute of Cardiovascular Disease and Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    J Biol Chem 281:1073-9. 2006
    ..This interaction requires apoE to be associated with a lipoprotein particle...
  55. ncbi Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants
    Kelly A Volcik
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Epidemiol 164:342-8. 2006
    ..Apolipoprotein E (ApoE) has been widely studied in regard to its role in lipid transport and metabolism, but the role that ApoE genetic ..
  56. pmc Familial apolipoprotein E deficiency
    E J Schaefer
    J Clin Invest 78:1206-19. 1986
    ..Homozygotes had only trace amounts of plasma apoE, and accumulations of apoB-48 and apoA-IV in VLDL, IDL, and low density lipoproteins...
  57. ncbi Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown...
  58. pmc Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA
    Arterioscler Thromb Vasc Biol 28:2078-84. 2008
    ..Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions...
  59. ncbi The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
    Jose Ruiz
    Department of Surgery, University of Maryland School of Medicine, Rockville, MD 21201, USA
    J Lipid Res 46:1721-31. 2005
    Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with members of the LDL receptor family. ApoE exists as three common isoforms that have important distinct functional and biological properties...
  60. ncbi Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..SR-BI and APOE genotypes, anthropometric, clinical, biochemical, and lifestyle variables were determined...
  61. pmc Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 89:655-65. 2007
    The epsilon(4) allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer's disease (LOAD), but LOAD pathology does not all fit neatly around APOE...
  62. pmc Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect
    Richard J Caselli
    Department of Neurology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    N Engl J Med 361:255-63. 2009
    The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease...
  63. ncbi Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
    Joerg Heeren
    Institute for Biochemistry and Molecular Biology II Molecular Cell Biology and Department of Internal Medicine, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 279:55483-92. 2004
    ..involves the targeting of lipids and apoprotein B along the degradative pathway and the recycling of TRL-derived apoE through recycling endosomes...
  64. ncbi Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women
    Jaana Gustavsson
    Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    Atherosclerosis 220:486-92. 2012
    Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary heart disease (CHD) risk. However, these associations may be modified by lifestyle factors...
  65. pmc Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics
    Bradford C Dickerson
    MGH Frontotemporal Dementia Unit, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 82:45-51. 2011
    ..AD) demonstrate disproportionate executive dysfunction relative to amnesia and how this relates to functional impairment in daily life, future clinical decline, APOE genotype and regional cortical thickness measured from MRI scan data.
  66. ncbi GAB2 is not associated with late-onset Alzheimer's disease in Chinese Han
    Kangguang Lin
    Department of Gerontology, Guangzhou Psychiatric Hospital, Affiliated Hospital of Guangzhou Medical College, 510370, Guangzhou, China
    Neurol Sci 31:277-81. 2010
    ..recently been shown that GAB2 alleles modify the risk for late-onset Alzheimer disease (LOAD) in apolipoprotein E (ApoE)epsilon4 allele carriers in a genome-wide association study...
  67. pmc Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Alzheimers Dis 22:307-13. 2010
    In vivo PET imaging studies of young-adult carriers of the apolipoprotein E ε4 allele (APOEε4), the major Alzheimer's disease (AD) susceptibility gene, have demonstrated declines in glucose metabolism in brain areas later vulnerable to ..
  68. ncbi A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease
    Jing Shi
    Clinical Neuroscience Research Group, University of Manchester, Hope Hospital, Salford, M6 8HD, UK
    Acta Neuropathol 111:15-20. 2006
    ..genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele...
  69. ncbi Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review
    June E Eichner
    Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Oklahoma City 73190, OK
    Am J Epidemiol 155:487-95. 2002
    ..examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease...
  70. pmc Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model
    Kazuchika Nishitsuji
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    J Biol Chem 286:17536-42. 2011
    Apolipoprotein E (apoE) is a major apolipoprotein in the brain. The ε4 allele of apoE is a major risk factor for Alzheimer disease, and apoE deficiency in mice leads to blood-brain barrier (BBB) leakage...
  71. pmc Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects
    S Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
    J Neurol Neurosurg Psychiatry 74:1148-51. 2003
    ..Strict diagnostic inclusion criteria were used to include well defined patients and controls. The results of apolipoprotein E (APOE) genotype effect on risk and clinical characteristics are presented.
  72. ncbi A case-control study on the effect of apoliprotein E genotype on head and neck cancer risk
    Emma De Feo
    Institute of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy
    Cancer Epidemiol Biomarkers Prev 19:2839-46. 2010
    The apolipoprotein E gene (apoE) has three major isoforms encoded by the ε2, ε3, and ε4 alleles, with the ε4 allele associated with hypercholesterolemia and the ε2 allele with the opposite effect...
  73. pmc APOE related alterations in cerebral activation even at college age
    N Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 76:1440-4. 2005
    Associations between the APOE genotype and various medical conditions have been documented at a very young age. The association between the APOE genotype and cognitive performance varies at different ages...
  74. pmc ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease
    Jaime Sánchez-Cuén
    División de Gastroenterología, Hospital Regional ISSSTE, Culiacan, Sinaloa 80230, Mexico
    World J Gastroenterol 16:4685-90. 2010
    To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population.
  75. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
    ....
  76. ncbi A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease
    Federico Licastro
    Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 26:449-53. 2005
    ..genotype was associated with an increased risk of EOAD independently from the presence of the apolipoprotein E (APOE) epsilon 4 allele...
  77. ncbi The relationship between apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphisms and hypertension: a meta-analysis of six studies comprising 1812 cases and 1762 controls
    WenQuan Niu
    Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China
    Hypertens Res 32:1060-6. 2009
    We performed a meta-analysis in an effort to systematically explore the association between apolipoprotein E (ApoE) epsilon2/epsilon3/epsilon4 polymorphisms and hypertension...
  78. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    The epsilon4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for Alzheimer's disease (AD), but limited work has suggested that APOE genotype may modulate disease phenotype...
  79. pmc Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Aging Cell 10:533-41. 2011
    ..We focus on the well-studied apolipoprotein E (APOE) e2/3/4 polymorphism and on lifespan and ages at onset of cardiovascular diseases (CVD) and cancer, using data on ..
  80. doi Apolipoprotein E genotype and the cardiovascular disease risk phenotype: impact of sex and adiposity (the FINGEN study)
    Bettina M Kofler
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, United Kingdom
    Atherosclerosis 221:467-70. 2012
    Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype × BMI/age/sex interactions...
  81. pmc APOE genotype alters glial activation and loss of synaptic markers in mice
    Yuangui Zhu
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Glia 60:559-69. 2012
    The ε4 allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and affects clinical outcomes of chronic and acute brain damages...
  82. pmc E2 allele of the apolipoprotein E gene polymorphism is predictive for obesity status in Roma minority population of Croatia
    Hrvojka Marija Zeljko
    Department of Internal Medicine, Clinical Hospital Merkur, Zajceva 19, 10000 Zagreb, Croatia
    Lipids Health Dis 10:9. 2011
    ..The present study explores whether the widely found cardiovascular diseases (CVD) risk effects of ACE I/D, APOE (ε2, ε3, ε4), eNOS-VNTR and LEP G2548A polymorphisms can be replicated in this specific population.
  83. pmc Comprehensive search for Alzheimer disease susceptibility loci in the APOE region
    Gyungah Jun
    Department of Medicine Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Arch Neurol 69:1270-9. 2012
    ..of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
  84. ncbi Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A
    Yanjuan Zhu
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
    J Biol Chem 278:36257-63. 2003
    ..Previous studies revealed that apolipoprotein E (apoE) is an effective inhibitor of platelet-derived growth factor-directed smooth muscle cell migration and ..
  85. ncbi Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Gen Psychiatry 61:518-24. 2004
    ..strongly with age, but little is known about the cumulative incidence of AD over a lifetime of 100 years, or its relationship to the polymorphic APOE locus that encodes apolipoprotein E. APOE is a strong genetic risk factor for AD.
  86. ncbi An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 340:29-32. 2003
    ..These findings show no evidence for an association between p53 codon 72 polymorphism and AD in our population...
  87. ncbi Characterization of the heparin binding sites in human apolipoprotein E
    Hiroyuki Saito
    Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 278:14782-7. 2003
    ..Both the 22-kDa N-terminal domain and 10-kDa C-terminal domain of apoE contain a heparin binding site; the N-terminal site overlaps with the low density lipoprotein receptor binding ..
  88. pmc Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
    Samuel T Henderson
    Accera, Inc, 380 Interlocken Crescent, Suite 780, Broomfield, Colorado 80021, USA
    Nutr Metab (Lond) 6:31. 2009
    ..abstract:..
  89. doi Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS
    Qin Xu
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    J Neurosci 28:1452-9. 2008
    ..In studying how apoE expression is regulated in neurons, we identified a splicing variant of apoE mRNA with intron-3 retention (apoE-I3)...
  90. ncbi Clinical features of rapidly progressive Alzheimer's disease
    Christian Schmidt
    Department of Neurology, Hospital of the Georg August University Goettingen, Goettingen, Germany
    Dement Geriatr Cogn Disord 29:371-8. 2010
    ..To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD)...
  91. pmc Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE
    Ellen M Wijsman
    Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 7:e1001308. 2011
    ..SNPs near APOE gave highly significant results (e.g., rs2075650, p = 3...
  92. doi Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Foggia, Italy
    Rejuvenation Res 13:645-52. 2010
    ..157 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotyped for the apolipoprotein E (APOE) polymorphism and the GSTO1 rs4925 and rs1804834 SNPs...
  93. doi Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions
    Bryan Maloney
    Department of Psychiatry, Institute of Psychiatric Research, Laboratory of Molecular Neurogenetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Med Genet B Neuropsychiatr Genet 153:185-201. 2010
    Variations in levels of apolipoprotein E (ApoE) have been tied to the risk and progression of Alzheimer's disease (AD)...
  94. ncbi Apolipoprotein E polymorphism, age and coronary heart disease
    Genovefa D Kolovou
    1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece
    Ageing Res Rev 6:94-108. 2007
    ..The most common apo E polymorphism has been found to influence blood lipid concentrations and its correlation with CHD has been ..
  95. ncbi Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele
    H A Wishart
    Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH 03756 0001, USA
    Neurology 67:1221-4. 2006
    To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele.
  96. doi Genetic and clinical predictors of warfarin dose requirements in African Americans
    L H Cavallari
    Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA
    Clin Pharmacol Ther 87:459-64. 2010
    ..vitamin K oxidoreductase complex subunit 1 (VKORC1), cytochrome P450 2C9 (CYP2C9), CYP4F2, or apolipoprotein E (APOE) polymorphisms contribute to variability in the warfarin maintenance dose beyond what is attributable to the CYP2C9*..
  97. pmc ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans
    Erdembileg Anuurad
    Department of Medicine, University of California, Davis, CA, USA
    J Lipid Res 50:1472-8. 2009
    ..Functional polymorphisms have been established in apoE but not in apoC-I...
  98. doi Apolipoprotein E genotype is related to progression of white matter lesion load
    Ophelia Godin
    Inserm Unit 708 Neuroepidemiology, Hopital La Salpetriere, Paris, France
    Stroke 40:3186-90. 2009
    ..We investigated whether the apolipoprotein E genotype influences baseline and evolution over 4-year follow-up of WML volumes in a population-based sample of 1779 nondemented subjects aged 65 to 80 years old at enrollment...
  99. pmc APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample
    Jaroslav A Hubacek
    Institute of Clinical and Experimental Medicine, Prague, Czech Republic
    Hum Immunol 71:304-8. 2010
    The published data remain inconsistent on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP), mainly because of low statistical power of previous studies...
  100. ncbi Apolipoprotein E and carotid artery atherosclerosis: the Rotterdam study
    A J Slooter
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
    Stroke 32:1947-52. 2001
    ..It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to atherosclerosis in the carotid arteries...
  101. pmc Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls
    Cathie Sudlow
    Division of Clinical Neurosciences, University of Edinburgh, United Kingdom
    Stroke 37:364-70. 2006
    Apolipoprotein E genotype (APOE) is associated with cholesterol metabolism, ischemic heart disease, and cerebral amyloid angiopathy, and so may affect risk of both ischemic and hemorrhagic stroke.

Research Grants192 found, 100 shown here

  1. Subgroups of Alzheimer Disease
    Khalid Iqbal; Fiscal Year: 2010
    ..b>APOE genotype frequencies and clinical profiles of each cluster, including symptoms such as depression, hallucinations, ..
  2. Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
    Gregory M Cole; Fiscal Year: 2013
    ..Emerging clinical data suggest a differential ApoE isoform-dependent response to NSAIDs, antioxidants (Hayden et al., 2007;Szekely et al...
  3. Next Generation Mendelian Genetics in Familial Alzheimer Disease
    Zoran Brkanac; Fiscal Year: 2013
    ..genome-wide association studies have not found strong evidence for the contribution of common variants besides the APOE gene...
  4. Genomic Search for Susceptibility to Alzheimer Disease
    Alison M Goate; Fiscal Year: 2010
    ..Studies of late onset AD (LOAD) have implicated genotype at the apolipoprotein E (APOE) locus as a major risk factor that also acts via an Ass dependent mechanism...
  5. The aging brain: Imaging genetics of brain structure and function
    Ira Driscoll; Fiscal Year: 2013
    ..The primary aims are to: (1) measure variation in five candidate genes (APOE, SORL1, BDNF, COMT, and KIBRA), all with known involvement in either dementia or cognitive impairment, and examine ..
  6. Genetic Epidemiology of HAD Susceptibility Genes
    Sunil Ahuja; Fiscal Year: 2009
    ..Aim #3 will test the hypothesis that neuronal susceptibility to MP-mediated inflammatory damage is linked to APOE genotypes...
  7. The Effects of APOE on Neuronal Networks
    SONYA DUMANIS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): ApolipoproteinE (ApoE) is a protein responsible for lipid transport and is implicated in a variety of mechanisms in the central nervous system ranging from neuronal development to brain repair...
  8. APOE and Brain Injury in Premies
    James A Blackman; Fiscal Year: 2010
    ..Studies have examined the effects of Apolipoprotein E (APOE) genotype on outcomes after BI, primarily in adults...
  9. Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain Injury
    Pratik Mukherjee; Fiscal Year: 2010
    ..Specifically, we will examine whether ApoE genotype influences the degree of regional brain atrophy and microstructural white matter injury...
  10. Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain Injury
    Pratik Mukherjee; Fiscal Year: 2011
    ..Specifically, we will examine whether ApoE genotype influences the degree of regional brain atrophy and microstructural white matter injury...
  11. Genetics of Telomere Dynamics in Okinawans
    Donald Craig Willcox; Fiscal Year: 2013
    ..Until recently, only variation within the APOE gene had been firmly associated with human lifespan and healthspan...
  12. Identifying Alzheimer's disease genes using genomic and family data
    ELIZABETH MARCHANI BLUE; Fiscal Year: 2013
    ..a postdoctoral fellow, she has recently published evidence that several genes in addition to APP, PSEN1, PSEN2, and APOE influence Alzheimer's disease...
  13. Genetic Factors that Impact the Risk of Alzheimer's Disease
    Allen Roses; Fiscal Year: 2009
    ..The general relationship between APOE genotype and the age of onset for AD is well-documented since 1993...
  14. Genetic Factors that Impact the Risk of Alzheimer's Disease
    Allen D Roses; Fiscal Year: 2010
    ..The general relationship between APOE genotype and the age of onset for AD is well-documented since 1993...
  15. Neuroanatomical Substrates of Aging & Cognitive Decline
    Gene E Alexander; Fiscal Year: 2010
    ..these factors include differences in blood pressure, aerobic fitness, and the presence of the apolipoprotein E (APOE) s4 allele, a common susceptibility gene for Alzheimer's disease...
  16. Low-Burden Tools for Improving Prediction and Diagnosis of Cognitive Impairment.
    VALERIE FRANCES REYNA; Fiscal Year: 2010
    ..g., the ApoE genotype), behavioral markers of impairment (e.g., neuropsychological tests), and clinical diagnoses of impairment...
  17. Low-Burden Tools for Improving Prediction and Diagnosis of Cognitive Impairment.
    CHARLES BRAINERD; Fiscal Year: 2009
    ..g., the ApoE genotype), behavioral markers of impairment (e.g., neuropsychological tests), and clinical diagnoses of impairment...
  18. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Importantly, APOE ?4, the major risk factor for AD, and ABCA7, recently associated with AD from GWAS, alter the neuronal transport of ..
  19. Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
    Michelle M Mielke; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The E4 allele of the Apolipoprotein E (ApoE) gene is the strongest genetic risk factor for the onset of sporadic Alzheimer's disease (AD) identified to date...
  20. Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
    Michelle M Mielke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The E4 allele of the Apolipoprotein E (ApoE) gene is the strongest genetic risk factor for the onset of sporadic Alzheimer's disease (AD) identified to date...
  21. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2010
    ..Health history and neurological exam, blood pressure, total and HDL cholesterol, and APOE genotype are already being measured on all participants...
  22. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ..In addition, there is an intrigue finding that apolipoprotein E (APOE) 54 allele carriers had significantly lower selenium levels measured in nail samples even though the two genotype ..
  23. PTSD, Sleep-Disordered Breathing and APOE Genotype: Effects on Cognition
    Jerome A Yesavage; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): To examine whether sleep disordered breathing (SDB), Apolipoprotein 54 (APOE 54) status, increasing age and their interactions will predict rate of cognitive decline in veterans who have PTSD, a ..
  24. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..that were found in GEMS provides adequate power for these analyses overall and within subgroups such as gender and ApoE genotype...
  25. Association of TFPI with antemortem dementia and postmortem micro brain infarcts
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..In Aim3 we will correlate the TFPI plasma concentrations and activity with lipoprotein levels and ApoE genotype of the cohort which have been previously determined...
  26. Amyloid Imaging, VMCI, and Analysis for ADNI
    Michael Weiner; Fiscal Year: 2009
    ..This sequence is influenced by factors including age, APOE genotype, cerebrovascular disease, and other pathologies...
  27. Amyloid Imaging, VMCI, and Analysis for ADNI
    Michael W Weiner; Fiscal Year: 2010
    ..This sequence is influenced by factors including age, APOE genotype, cerebrovascular disease, and other pathologies...
  28. BIOMARKERS AND GENETICS CORE
    Joseph F Quinn; Fiscal Year: 2012
    ..This will include: a) apolipoprotein E (APOE) genotype on all subjects, b) single nucleotide polymorphism (SNP) profiles on select aging cohorts, and c) CSF ..
  29. Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers
    Robert A Stern; Fiscal Year: 2013
    ..In addition, APOE genotype will be examined as a potential moderating variable, based on our neuropathological findings and other ..
  30. Progression of Dementia: A Population Study
    JOANN T contact TSCHANZ; Fiscal Year: 2010
    ..occur in clusters, c) vascular factors, their treatments, and the care environment modify progression, and d) the APOE e4 allele modifies the effects of other factors...
  31. ANTECEDENT BIOMARKERS FOR AD: THE ADULT CHILDREN STUDY
    John Morris; Fiscal Year: 2011
    ..A?, tau, and sulfatide) and conduct proteomic studies to evaluate AD risk as a function of family history and apoE genotype...
  32. TWO PRECLINICAL LATENT SCORES TO PREDICT OCCURRENCE OF DAT
    Chengjie Xiong; Fiscal Year: 2010
    ..g., education and cognitive activities), ApoE genotype, preclinical measures of biomarkers including cerebrospinal fluid (CSF) molecular biomarkers, MRI brain ..
  33. TWO PRECLINICAL LATENT SCORES TO PREDICT OCCURRENCE OF DAT
    Chengjie Xiong; Fiscal Year: 2013
    ..g., education and cognitive activities), ApoE genotype, preclinical measures of biomarkers including cerebrospinal fluid (CSF) molecular biomarkers, MRI brain ..
  34. The Anterior Cingulate Cortex and Cognitive Aging
    Jose V Pardo; Fiscal Year: 2013
    ..2) Model in a longitudinal design using existing normative ADNI data resting ACC metabolism as a function of age, APOE genotype, education, etc. and determine whether ACC hypometabolism predicts those who convert to MCI...
  35. APOEomic: Searching for APOE interacting risk factors using omics data
    Amanda J Myers; Fiscal Year: 2013
    ..Each GWAS that has been published to date has mapped the Apolipoprotein E (APOE) locus as the strongest LOAD risk signal within the human genome...
  36. Biological Underpinnings and Cognitive Expression of Brain Aging
    Po Lu; Fiscal Year: 2009
    ..Cross-sectional data has demonstrated differential myelin breakdown in association with ApoE genotype with ApoE4 carriers manifesting more severe myelin breakdown...
  37. Biological Underpinnings and Cognitive Expression of Brain Aging
    Po Lu; Fiscal Year: 2010
    ..Cross-sectional data has demonstrated differential myelin breakdown in association with ApoE genotype with ApoE4 carriers manifesting more severe myelin breakdown...
  38. The APOE TR Mouse: A Model for Elucidating Pathogenic Mechanisms of AMD
    Catherine Bowes Rickman; Fiscal Year: 2010
    ..AMD is also influenced by specific AMD-susceptibility genes. One of these is the APOE gene coding for the apolipoprotein E protein a key regulator of cholesterol and lipoprotein metabolism...
  39. ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
    Robert W Mahley; Fiscal Year: 2013
    ..Two major isoforms of apoE, apoE3 and apoE4, are expressed in the brain...
  40. Underlying Mechanisms of ApoE in HCV Infection and Assembly
    GUANGXIANG GEORGE LUO; Fiscal Year: 2013
    ..The overall goal of this application is to determine the importance of the cellular protein apolipoprotein E (apoE) in hepatitis C virus (HCV) infection and production in vivo and to define the underlying molecular mechanism of ..
  41. Freatures of Metabolic Syndrome and Risk for AD among Adults with Down Syndrome
    Warren B Zigman; Fiscal Year: 2011
    ..However, with the exception of age, apolipoprotein E (APOE) genotype, age at menopause and cholesterol level, few additional risk factors have been identified...
  42. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    JOACHIM J HERZ; Fiscal Year: 2013
    ..Three isoforms of ApoE exist in the human population, E2, E3 and E4...
  43. Influence of apoE on LRP1 function and Beta-Amyloid Transport Across the BBB
    Fiona C Crawford; Fiscal Year: 2012
    ..One of the ligands with which LRP1 interacts is apolipoprotein E (apoE) and possession of the E4 allele represents the strongest genetic risk factor for AD...
  44. Building a Better AMD Mouse
    Caroline J Zeiss; Fiscal Year: 2010
    ..In Aim 1, we will breed mice lacking one or more genes conferring AMD risk in humans (CFH) or mice (ApoE, Ccr2) and expose these to normal or high fat high cholesterol diets...
  45. ACTIVE Phase III: IU Field Site
    Frederick W Unverzagt; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  46. ACTIVE Phase III: HRC Field Site
    John N Morris; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  47. ACTIVE Phase III: UAB Field Site
    Karlene K Ball; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  48. Influence of apoE on LRP1 function and Beta-Amyloid Transport Across the BBB
    Fiona C Crawford; Fiscal Year: 2013
    ..One of the ligands with which LRP1 interacts is apolipoprotein E (apoE) and possession of the E4 allele represents the strongest genetic risk factor for AD...
  49. Role of Fibrin in Alzheimer's Disease
    Sidney Strickland; Fiscal Year: 2010
    ..In keeping with the known genetic interaction between AD and the ApoE genotype, we have also demonstrated that the different ApoE isoforms differentially affect the fibrinogen/Ab ..
  50. Lifespan Stressors and Alzheimer's Disease: The Cache County Study
    Maria C Norton; Fiscal Year: 2010
    ..adversity places those with later adversity at enhanced risk, 3) Examine Early-onset Major Depression (EOD) and APOE for moderating effects on the association between life stressors and cognitive outcomes...
  51. ALZHEIMERS DISEASE RESEARCH CENTER
    John Morris; Fiscal Year: 2013
    ..Changing tau protein levels and tau protein isoforms in mouse models of dementia;(Timothy Miller) 3. APOE metabolism in AD and controls;(Randall Bateman).
  52. ALZHEIMERS DISEASE RESEARCH CENTER
    John Morris; Fiscal Year: 2010
    ..Changing tau protein levels and tau protein isoforms in mouse models of dementia;(Timothy Miller) 3. APOE metabolism in AD and controls;(Randall Bateman).
  53. ACTIVE Phase III: UF/WSU Field Site
    Michael Marsiske; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  54. ACTIVE Phase III: JHU Field Site
    George W Rebok; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  55. ACTIVE Phase III: PSU Field Site
    Sherry L Willis; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  56. Risk Factors for Cognitive Decline in African-Americans
    Lisa L Barnes; Fiscal Year: 2010
    ..in the associations of neuropathology to level of and change in cognitive function;3) test the hypothesis that the APOE e4 allele is associated with increased levels of AD pathology, and the 52 allele is associated with a lower level ..
  57. National Cell Respository for Alzheimer's Disease (NCRAD) (U24)
    Tatiana M Foroud; Fiscal Year: 2012
    ..also widely distributes samples both to investigators for their own analyses as well as to central cores, where APOE genotyping, genomewide SNP arrays, and now whole genome and whole exome sequencing studies are performed...
  58. Role of Fibrinogen in Alzheimer's Disease
    Sidney Strickland; Fiscal Year: 2013
    ..In keeping with the known genetic interaction between AD and the ApoE genotype, we have also demonstrated that ApoE affects the interaction between fibrinogen and A[unreadable] and the ..
  59. The VETSA Longitudinal Twin Study of Cognition and Aging
    William S Kremen; Fiscal Year: 2012
    ..cognitive effort and performance (Aims 1, 2), and to examine major factors that mediate or moderate those changes: APOE [Aim 3];other biomedical risks [Aim 4];lifestyle/psychosocial factors [Aim 5])...
  60. MRI Biomarker Discovery for Preclinical Alzheimers Disease with Geometry Methods
    Yalin Wang; Fiscal Year: 2013
    ..We will develop and apply novel geometric algorithms to brain MRIs obtained from the well-characterized Arizona APOE cohort of presymptomatic individuals and the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset...
  61. KEEPS Cognitive and Affective Study
    Sanjay Asthana; Fiscal Year: 2013
    ..between estrogen-related changes in proposed markers of inflammation, blood hypercoagulability, and tests of cognition and mood, and 5) to determine if ApoE genotype will influence cognitive responsitivity to HT.
  62. The role of apoE and APOE genotype in amyloid-beta clearance after TBI
    Mark P Burns; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): After traumatic brain injury (TBI) the human APOE-[unreadable]4 (APOE4) gene polymorphism is associated with increased mortality, increased coma time, poor prognosis, and an increased risk of late-..
  63. The role of apoE and APOE genotype in amyloid-beta clearance after TBI
    Mark P Burns; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): After traumatic brain injury (TBI) the human APOE-[unreadable]4 (APOE4) gene polymorphism is associated with increased mortality, increased coma time, poor prognosis, and an increased risk of late-..
  64. The VETSA Longitudinal MRI Twin Study of Aging
    William S Kremen; Fiscal Year: 2013
    ..determine genetic and environmental influences on brain structure changes over time;3) examine the relationship of APOE genotype to changes in brain structure over time;4) elucidate biomedical and other risk factors related to changes ..
  65. Apolipoprotein E Genotype and Cognitive Performance in Breast Cancer Survivors
    Brent Small; Fiscal Year: 2006
    ..provided by applicant): In recent years there has been considerable interest in the e4 allele of Apolipoprotein E (APOE), a genetic risk factor for Alzheimer's disease, as a risk factor for cognitive impairment in healthy aging...
  66. The Effect of Physical Activity on Cognition Relative to APOE Genotype
    Jennifer L Etnier; Fiscal Year: 2013
    ..baseline PA and subsequent cognitive performance is moderated by a susceptibility gene for AD (apolipoprotein, APOE) [10-13]...
  67. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2013
    ..conduct structure-function analysis of ACAT1 in vitro, and to examine the role of macrophage ACAT1 in vivo in the Apoe-/- mouse model and the Ldlr-/- apoB48-deficient mouse model for atherosclerosis...
  68. Epigenomics of Alzheimer's Disease
    Benjamin Tycko; Fiscal Year: 2013
    ..emphasis in AD research has been on genetic studies, which have uncovered the fundamental involvement of the APP, APOE and PS1 genes...
  69. ApoE isoform-specific therapy for Alzheimer disease
    Guojun Bu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The [unreadable]4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) compared to the more common [unreadable]3 allele...
  70. Functions of Lipoprotein Receptors in Alzheimer Disease
    G Rebeck; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...
  71. Functions of Lipoprotein Receptors in Alzheimer Disease
    G Rebeck; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...
  72. Functions of Lipoprotein Receptors in Alzheimer Disease
    G Rebeck; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...
  73. Functions of Lipoprotein Receptors in Alzheimer Disease
    G Rebeck; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...
  74. Functions of Lipoprotein Receptors in Alzheimer Disease
    G Rebeck; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...