ApoE

Summary

Gene Symbol: ApoE
Description: apolipoprotein E
Alias: AD2, APO-E, ApoE4, LDLCQ5, LPG, apolipoprotein E, apolipoprotein E3
Species: human
Products:     ApoE

Top Publications

  1. Li H, Wetten S, Li L, St Jean P, Upmanyu R, Surh L, et al. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol. 2008;65:45-53 pubmed
    ..Unadjusted, SNP RS4420638 within APOC1 was strongly associated with AD due entirely to linkage disequilibrium with APOE. In the multivariable adjusted analyses, 3 SNPs within the top 120 by P value in the logistic analysis and 1 in the ..
  2. Conway V, Allard M, Minihane A, Jackson K, Lovegrove J, Plourde M. Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?. Lipids Health Dis. 2014;13:148 pubmed publisher
    ..chylomicron CM), Sf 60 - 400 (VLDL1), and Sf 20 - 60 (VLDL2) according to APOE genotype...
  3. Krimbou L, Denis M, Haidar B, Carrier M, Marcil M, Genest J. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J Lipid Res. 2004;45:839-48 pubmed
    b>Apolipoprotein E (apoE)/ABCA1 interactions were investigated in human intact fibroblasts induced with 22(R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells)...
  4. Liang S, Steffen L, Steffen B, Guan W, Weir N, Rich S, et al. APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2013;228:181-7 pubmed publisher
    ..acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes...
  5. Vedhachalam C, Narayanaswami V, Neto N, Forte T, Phillips M, Lund Katz S, et al. The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry. 2007;46:2583-93 pubmed
    This study was undertaken to identify the alpha-helical domains of human apoE that mediate cellular cholesterol efflux and HDL assembly via ATP-binding cassette transporter A1 (ABCA1)...
  6. Gungor Z, Anuurad E, Enkhmaa B, Zhang W, Kim K, Berglund L. Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk. Atherosclerosis. 2012;223:230-4 pubmed publisher
    b>Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties...
  7. Moore L, Brennan P, Karami S, Menashe I, Berndt S, Dong L, et al. Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. Cancer Res. 2009;69:8001-8 pubmed publisher
    ..S. study were within a regulatory region of the APOE promoter. The OR for rs8106822 A>G variant was 1.22(AG) and 1.41(GG) (P(trend) = 0.01) in the European study, 1...
  8. McKay G, Patterson C, Chakravarthy U, Dasari S, Klaver C, Vingerling J, et al. Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. Hum Mutat. 2011;32:1407-16 pubmed publisher
    ..Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation...
  9. Dean D, Jerskey B, Chen K, Protas H, Thiyyagura P, Roontiva A, et al. Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. JAMA Neurol. 2014;71:11-22 pubmed publisher
    ..myelin water fraction (MWF) and gray matter volume (GMV) in healthy infant carriers and noncarriers of the apolipoprotein E (APOE) ε4 allele, the major susceptibility gene for late-onset AD...

More Information

Publications139 found, 100 shown here

  1. Jun G, Vardarajan B, Buros J, Yu C, Hawk M, Dombroski B, et al. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol. 2012;69:1270-9 pubmed
    ..of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523)...
  2. Bergeron Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, et al. Multilocus analysis of age-related macular degeneration. Eur J Hum Genet. 2009;17:1190-9 pubmed publisher
    ..factor B (CFB), age-related maculopathy susceptibility (ARMS2), HtrA serine peptidase 1 (HTRA1), and apolipoprotein E (APOE)...
  3. Frikke Schmidt R, Sing C, Nordestgaard B, Steffensen R, Tybjaerg Hansen A. Subsets of SNPs define rare genotype classes that predict ischemic heart disease. Hum Genet. 2007;120:865-77 pubmed
    ..In this study we determined the utility of exonic and 5' SNPs in apolipoprotein E (APOE) and lipoprotein lipase (LPL) when considered singly and in combination for predicting incidence of IHD ..
  4. Heeren J, Grewal T, Laatsch A, Becker N, Rinninger F, Rye K, et al. Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation. J Biol Chem. 2004;279:55483-92 pubmed
    ..Since epidemiological data showed that apoE3 and apoE4 have differential effects on HDL metabolism, we investigated whether the intracellular processing of TRL-derived ..
  5. Ken Dror G, Talmud P, Humphries S, Drenos F. APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men. Mol Med. 2010;16:389-99 pubmed publisher
    The role of common APOE variants on plasma lipids, particularly low density lipoprotein (LDL) levels, and coronary heart disease (CHD) risk is well known; the influence of variation in the other nearby apolipoprotein genes APOC1, APOC4 ..
  6. Davies G, Harris S, Reynolds C, Payton A, Knight H, Liewald D, et al. A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Mol Psychiatry. 2014;19:76-87 pubmed publisher
    ..This result was replicated in a meta-analysis of three independent Swedish cohorts (P=2.41 × 10(-6)). An Apolipoprotein E (APOE) haplotype (adjacent to TOMM40), previously associated with cognitive ageing, had a significant effect ..
  7. Seshadri S, Fitzpatrick A, Ikram M, Destefano A, Gudnason V, Boada M, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010;303:1832-40 pubmed publisher
    ..with AD in this independent sample, they did not improve the ability of a model that included age, sex, and APOE to predict incident AD (improvement in area under the receiver operating characteristic curve from 0.847 to 0...
  8. Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, et al. Apolipoprotein E and familial longevity. Neurobiol Aging. 2013;34:1287-91 pubmed publisher
    Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased ..
  9. Tsuang D, Leverenz J, Lopez O, Hamilton R, Bennett D, Schneider J, et al. APOE ?4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013;70:223-8 pubmed publisher
    To test for an association between the apolipoprotein E (APOE) ?4 allele and dementias with synucleinopathy. Genetic case-control association study. Academic research...
  10. Elliott P, Chambers J, Zhang W, Clarke R, Hopewell J, Peden J, et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 2009;302:37-48 pubmed publisher
    ..9%; P = 1.3 x 10(-38)), rs1183910 in HNF1A (-13.8%; 95% CI, -16.6% to -10.9%; P = 1.9 x 10(-18)), and rs4420638 in APOE-CI-CII (-21.8%; 95% CI, -25.3% to -18.1%; P = 8.1 x 10(-26))...
  11. Minagawa H, Gong J, Jung C, Watanabe A, Lund Katz S, Phillips M, et al. Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. J Neurosci Res. 2009;87:2498-508 pubmed publisher
    We determined the molecular mechanisms underlying apolipoprotein E (ApoE)-isoform-dependent lipid efflux from neurons and ApoE-deficient astrocytes in culture. The ability of ApoE3 to induce lipid efflux was 2.5- to 3...
  12. Maloney B, Ge Y, Petersen R, Hardy J, Rogers J, Pérez Tur J, et al. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:185-201 pubmed publisher
    Variations in levels of apolipoprotein E (ApoE) have been tied to the risk and progression of Alzheimer's disease (AD)...
  13. Morgan E, Woods S, Letendre S, Franklin D, Bloss C, Goate A, et al. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. J Neurovirol. 2013;19:150-6 pubmed publisher
    ..a cross-sectional, observational study to evaluate the hypothesis that HIV-seropositive (HIV+) apolipoprotein E4 (APOE4) carriers are at increased risk for HIV-associated neurocognitive disorders (HAND) compared to APOE4 noncarriers ..
  14. Chiang G, Insel P, Tosun D, Schuff N, Truran Sacrey D, Raptentsetsang S, et al. Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011;7:514-20 pubmed publisher
    ..Apolipoprotein ɛ4 (APOE ɛ4), a genetic risk factor for Alzheimer's disease, is also known to be associated with hippocampal volume loss...
  15. Bonner Jackson A, Okonkwo O, Tremont G. Apolipoprotein E ε2 and functional decline in amnestic mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry. 2012;20:584-93 pubmed publisher
    Recent work has demonstrated the potentially protective effects of the apolipoprotein E (APOE) ε2 allele on cognitive functioning in individuals at risk for developing Alzheimer disease...
  16. Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, et al. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Mol Psychiatry. 2012;17:1316-27 pubmed publisher
    ..Aside from the apolipoprotein E (APOE) locus, the strongest evidence for association was observed in an intergenic region on chromosome 4 (..
  17. Hubacek J, Bloudickova S, Kubinova R, Pikhart H, Viklicky O, Bobak M. Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls. Biochem Genet. 2009;47:688-93 pubmed publisher
    A possible association between end-stage renal disease (ESRD) and apolipoprotein E (APOE) polymorphism was found in some but not all studies...
  18. Federoff M, Jimenez Rolando B, Nalls M, Singleton A. A large study reveals no association between APOE and Parkinson's disease. Neurobiol Dis. 2012;46:389-92 pubmed publisher
    Research focusing on the role of APOE in Parkinson's disease (PD) has been largely inconclusive, creating a broad discrepancy in association studies...
  19. Sundar P, Feingold E, Minster R, DeKosky S, Kamboh M. Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease. Neurobiol Aging. 2007;28:856-62 pubmed
    ..Our data suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and LOAD.
  20. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 2009;41:1088-93 pubmed publisher
    ..In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1...
  21. Schiepers O, Harris S, Gow A, Pattie A, Brett C, Starr J, et al. APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921. Mol Psychiatry. 2012;17:315-24 pubmed publisher
    Carriers of the APOE E4 allele have an increased risk of developing Alzheimer's disease. However, it is less clear whether APOE E4 status may also be involved in non-pathological cognitive ageing...
  22. Tsai S, Gau Y, Liu M, Hsieh C, Liou Y, Hong C. Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males without dementia. Neurosci Lett. 2008;433:158-62 pubmed publisher
    ..Among the many associated genes, brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE), as two of the most frequently studied, might be good prospects for cognitive genetics...
  23. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt N, Roos C, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240-9 pubmed publisher
    ..The score did not improve risk discrimination but did modestly improve clinical risk reclassification for individual subjects beyond standard clinical factors. ..
  24. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T. Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A. 1992;89:9252-6 pubmed
    ..specificity, and tissue expression of the mRNAs, we suggest that this VLDL receptor may mediate uptake of apolipoprotein E-containing lipoproteins enriched with triglyceride in nonhepatic tissues that are active in fatty acid ..
  25. Wang M, Jia J. The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers. Neurosci Lett. 2010;482:260-3 pubmed publisher
    ..Definitive genotyping of these markers and apolipoprotein E (APOE) polymorphism were surveyed in 341 SAD patients and 421 controls...
  26. Ishigami M, Swertfeger D, Granholm N, Hui D. Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. J Biol Chem. 1998;273:20156-61 pubmed
    ..The purpose of this study was to ascertain if apoE also may have cytostatic functions that could attenuate vascular occlusive diseases...
  27. Irie F, Masaki K, Petrovitch H, Abbott R, Ross G, Taaffe D, et al. Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study. Arch Gen Psychiatry. 2008;65:906-12 pubmed publisher
    The apolipoprotein E epsilon4 (APOE epsilon4) allele is a genetic risk factor for Alzheimer disease. Recently, depression has also become recognized as a risk factor for dementia...
  28. Trachtenberg A, Filippini N, Ebmeier K, Smith S, Karpe F, Mackay C. The effects of APOE on the functional architecture of the resting brain. Neuroimage. 2012;59:565-72 pubmed publisher
    There is a well-established association between APOE genotype and the risk of developing Alzheimer's disease (AD)...
  29. Huang D, Weisgraber K, Strittmatter W, Matthew W. Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Exp Neurol. 1995;136:251-7 pubmed
    ..Laminin binds other basement membrane components, including heparan sulfate proteoglycans. Apolipoprotein E (apoE) also binds basement membrane and heparan sulfate proteoglycans and colocalizes with s-laminin in the ..
  30. Maruszak A, Safranow K, Branicki W, Gaweda Walerych K, Pośpiech E, Gabryelewicz T, et al. The impact of mitochondrial and nuclear DNA variants on late-onset Alzheimer's disease risk. J Alzheimers Dis. 2011;27:197-210 pubmed publisher
    ..25, respectively). Haplogroup K was demonstrated to exert a neutralizing effect on the high risk associated with APOE4+ status (p = 0.014). Further, two synergistic interactions between subhaplogroup H5 and APOE4 status (p = 0...
  31. Driscoll I, McDaniel M, Guynn M. Apolipoprotein E and prospective memory in normally aging adults. Neuropsychology. 2005;19:28-34 pubmed
    The epsilon4 allele of apolipoprotein E (APOE) is an established risk factor for Alzheimer's disease, despite uncertainty as to its effect on cognitive function in normal aging...
  32. Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Stopford C, et al. Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease. Dement Geriatr Cogn Disord. 2007;23:60-6 pubmed
    The age distribution of the epsilon4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer's disease (AD) with onset age ranging from 35 to 90 years...
  33. Kring S, Brummett B, Barefoot J, Garrett M, Ashley Koch A, Boyle S, et al. Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosom Med. 2010;72:427-33 pubmed publisher
    To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as ..
  34. Lahlali Kacemi N, Bamou Y, Guedira A, Hassani M, Visvikis S, Siest G, et al. [Apolipoprotein E polymorphism in a Moroccan population: allele frequency and relation to plasma lipid concentrations]. Ann Biol Clin (Paris). 2002;60:73-8 pubmed
    To date, no data are available on relationship between apolipoprotein E (apo E) polymorphism and lipid levels in Moroccan population...
  35. Handley O, Morrison C, Miles C, Bayer A. ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults. Neurobiol Aging. 2006;27:1425-30 pubmed
    ..All participants were genotyped for the presence of the ApoE epsilon4 allele...
  36. Tikellis G, Sun C, Gorin M, Klein R, Klein B, Larsen E, et al. Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. Arch Ophthalmol. 2007;125:68-73 pubmed
    To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population...
  37. Yue L, Mazzone T. Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane. J Lipid Res. 2011;52:489-98 pubmed publisher
    ..Recently, endogenous expression of apoE in adipocytes has been shown to play an important role in adipocyte lipoprotein metabolism and gene expression ..
  38. Hawi Z, Sheehan K, Lynch A, Evans I, Lowe N, Lawlor B, et al. Late onset Alzheimer's disease and apolipoprotein association in the Irish population: relative risk and attributable fraction. Ir J Med Sci. 2003;172:74-6 pubmed
    Familial and sporadic late onset Alzheimer's disease (LOAD) shows a consistent genetic association with APOE epsilon4. To examine the role of APOE in the AD Irish population...
  39. Karpouzis A, Caridha R, Tripsianis G, Michailidis C, Martinis G, Veletza S. Apolipoprotein E gene polymorphism in psoriasis. Arch Dermatol Res. 2009;301:405-10 pubmed publisher
    Polymorphism in the apolipoprotein E gene has been associated with several neurological, cardiological and ophthalmological diseases...
  40. Fleisher A, Sherzai A, Taylor C, Langbaum J, Chen K, Buxton R. Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups. Neuroimage. 2009;47:1678-90 pubmed publisher
    ..AD and at least one copy of the apolipoprotein e4 allele compared to 12 individuals who were not carriers of the APOE4 gene and did not have a family history of AD...
  41. Engelborghs S, Dermaut B, Goeman J, Saerens J, Marien P, Pickut B, et al. Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. J Neurol Neurosurg Psychiatry. 2003;74:1148-51 pubmed
    ..Strict diagnostic inclusion criteria were used to include well defined patients and controls. The results of apolipoprotein E (APOE) genotype effect on risk and clinical characteristics are presented...
  42. Scarmeas N, Habeck C, Hilton J, Anderson K, Flynn J, Park A, et al. APOE related alterations in cerebral activation even at college age. J Neurol Neurosurg Psychiatry. 2005;76:1440-4 pubmed
    Associations between the APOE genotype and various medical conditions have been documented at a very young age. The association between the APOE genotype and cognitive performance varies at different ages...
  43. Ravaglia G, Forti P, Maioli F, Chiappelli M, Montesi F, Bianchin M, et al. Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly. Am J Clin Nutr. 2006;84:1473-80 pubmed
    b>Apolipoprotein E (APOE) plays a central role in VLDL metabolism...
  44. Zhao J, Brunner E, Kumari M, Singh Manoux A, Hawe E, Talmud P, et al. APOE polymorphism, socioeconomic status and cognitive function in mid-life--the Whitehall II longitudinal study. Soc Psychiatry Psychiatr Epidemiol. 2005;40:557-63 pubmed
    The aim of this study was to investigate the association of the common apolipoprotein E gene (APOE) variants with cognitive function and cognitive decline in adult mid-life and explore the possibility that APOE genotype mediates the link ..
  45. Chaudhary R, Likidlilid A, Peerapatdit T, Tresukosol D, Srisuma S, Ratanamaneechat S, et al. Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease. Cardiovasc Diabetol. 2012;11:36 pubmed publisher
    The most common apolipoprotein E (apoE) gene polymorphism has been found to influence plasma lipid concentration and its correlation with coronary artery disease (CAD) has been extensively investigated in the last decade...
  46. Wilson C, Wardell M, Weisgraber K, Mahley R, Agard D. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science. 1991;252:1817-22 pubmed
    Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor...
  47. Darreh Shori T, Modiri N, Blennow K, Baza S, Kamil C, Ahmed H, et al. The apolipoprotein E ?4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. Neurobiol Aging. 2011;32:1236-48 pubmed publisher
    The apolipoprotein E (ApoE) ?4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure...
  48. O Dwyer L, Lamberton F, Matura S, Scheibe M, Miller J, Rujescu D, et al. White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. PLoS ONE. 2012;7:e36024 pubmed publisher
    The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD)...
  49. Zak I, Balcerzyk A, Sarecka B, Niemiec P, Ciemniewski Z, Dylag S. Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. Clin Chim Acta. 2005;362:110-8 pubmed
    ..The aim of our study was to assess the polymorphic variants frequencies of ICAM1, APOE, PPARA and PAI-1 genes in CAD patients and healthy blood donors and to find specific arrangement of polymorphic ..
  50. Mayila W, Fang M, Cheng Z, Qiu C. [Polymorphism of apolipoprotein E gene and natural longevity in the Xinjiang Uighur people: an association study]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:462-3 pubmed
    To explore the distribution of polymorphisms of apolipoprotein E(apoE) gene and its relation to natural longevity in the Xinjiang Uighur people...
  51. Coon K, Myers A, Craig D, Webster J, Pearson J, Lince D, et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry. 2007;68:613-8 pubmed
    While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19...
  52. Ridker P, Pare G, Parker A, Zee R, Danik J, Buring J, et al. Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet. 2008;82:1185-92 pubmed publisher
    ..2, and the remaining four loci are in or near the leptin receptor protein gene, the apolipoprotein E gene, the interleukin-6 receptor protein gene, or the CRP gene itself...
  53. Feulner T, Laws S, Friedrich P, Wagenpfeil S, Wurst S, Riehle C, et al. Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry. 2010;15:756-66 pubmed publisher
    ..In addition to the apolipoprotein E locus, we identified nominally significant association signals in six of the ten genes investigated, albeit ..
  54. Sullivan P, Mezdour H, Quarfordt S, Maeda N. Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest. 1998;102:130-5 pubmed
    To study isoform-specific effects of apolipoprotein E (apoE) in vivo, we generated mice with a human APOE*2 allele in place of the mouse Apoe gene via targeted gene replacement in embryonic stem cells...
  55. Rovio S, Kåreholt I, Viitanen M, Winblad B, Tuomilehto J, Soininen H, et al. Work-related physical activity and the risk of dementia and Alzheimer's disease. Int J Geriatr Psychiatry. 2007;22:874-82 pubmed
    ..during life, income at midlife, leisure-time physical activity, other subtype of work-related physical activity, ApoE genotype, vascular disorders and the smoking status...
  56. Barbagallo C, Polizzi F, Severino M, Rizzo M, Vivona N, Onorato F, et al. ApoE polymorphism in a small Mediterranean island: relationships with plasma lipids, lipoproteins and LDL particle size. Eur J Epidemiol. 2001;17:707-13 pubmed
    Polymorphisms of apoE gene are able to modulate lipoprotein metabolism at different steps and to influence LDL-cholesterol (LDL-C) levels and also other lipoproteins features...
  57. Anttila T, Helkala E, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, et al. Midlife income, occupation, APOE status, and dementia: a population-based study. Neurology. 2002;59:887-93 pubmed
    To examine the relationship between socioeconomic factors and APOE carrier status on the development of dementia...
  58. Bekris L, Galloway N, Montine T, Schellenberg G, Yu C. APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:409-417 pubmed publisher
    Currently the epsilon4 allele of the apolipoprotein E gene (APOE) is the strongest genetic risk factor for late onset Alzheimer's disease (AD)...
  59. Marchant N, King S, Tabet N, Rusted J. Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. 2010;35:1090-6 pubmed publisher
    ..We sought to investigate the profile of young-adult apolipoprotein E (APOE) varepsilon4 carriers across cognitive domains given that possession of this gene variant increases ..
  60. Liu S, Ma J, Ridker P, Breslow J, Stampfer M. A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men. Atherosclerosis. 2003;166:323-9 pubmed
    b>Apolipoprotein E (apoE) plays an important role in lipid metabolism. Three common alleles in the APOE gene, E2/E3/E4, have been associated with lipoprotein disorders but their effects on myocardial infarction (MI) risk remain uncertain...
  61. Bathum L, Christiansen L, Jeune B, Vaupel J, McGue M, Christensen K. Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians. J Am Geriatr Soc. 2006;54:654-8 pubmed
    To evaluate the extent to which relationships between apolipoprotein E, cognitive functioning, and survival in people aged 60 to 80 persist into advanced old age...
  62. Hubacek J, Peasey A, Pikhart H, Stavek P, Kubinova R, Marmot M, et al. APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample. Hum Immunol. 2010;71:304-8 pubmed publisher
    The published data remain inconsistent on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP), mainly because of low statistical power of previous studies...
  63. Wang P, Hong C, Lin K, Liu H, Chen W. APOE ?4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan. J Neurol Neurosurg Psychiatry. 2011;82:165-9 pubmed publisher
    To evaluate the effect of the apolipoprotein E (APOE) ?4 in the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) in ethnic Chinese people in Taiwan...
  64. Perugini M, Schuck P, Howlett G. Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions. Eur J Biochem. 2002;269:5939-49 pubmed
    ..J.78, 1606-1619]. The new methods were developed to investigate the binding of human apolipoprotein E (apoE) isoforms to size-fractionated lipid emulsions, and demonstrate that apoE3 binds preferentially to ..
  65. Price D, Bassendine M, Norris S, Golding C, Toms G, Schmid M, et al. Apolipoprotein epsilon3 allele is associated with persistent hepatitis C virus infection. Gut. 2006;55:715-8 pubmed
    ..b>Apolipoprotein E (APOE) is found in VLDL and binds to potential receptors involved in HCV entry into cells, the LDL receptor, ..
  66. Dobson C, Sales S, Hoggard P, Wozniak M, Crutcher K. The receptor-binding region of human apolipoprotein E has direct anti-infective activity. J Infect Dis. 2006;193:442-50 pubmed
    ..We have examined the direct anti-infective activity of a peptide analogue of the receptor-binding region of apolipoprotein E (apoE) that is known as "apoE dimer tandem repeat peptide" (apoEdp) and has previously been shown ..
  67. Peter I, Crosier M, Yoshida M, Booth S, Cupples L, Dawson Hughes B, et al. Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis. Osteoporos Int. 2011;22:1199-209 pubmed publisher
    To determine the association of the Apolipoprotein E (APOE) E4 gene polymorphism with bone mineral density (BMD) and fractures we conducted a meta-analysis of 17 reports...
  68. Xuan C, Zhang B, Li M, Deng K, Yang T, Zhang X. No association between APOE ? 4 allele and multiple sclerosis susceptibility: a meta-analysis from 5472 cases and 4727 controls. J Neurol Sci. 2011;308:110-6 pubmed publisher
    b>Apolipoprotein E (APOE) gene ?4, 2 alleles have been reported to be associated with multiple sclerosis (MS), but results were conflicting. In order to derive a more precise estimation of the associations, a meta-analysis was performed...
  69. Heijmans B, Slagboom P, Gussekloo J, Droog S, Lagaay A, Kluft C, et al. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. Am J Med Genet. 2002;107:201-8 pubmed
    The common apolipoprotein E (APOE) alleles epsilon2, epsilon3, and epsilon4 are associated with the risk of dementia and cardiovascular disease...
  70. Kivipelto M, Rovio S, Ngandu T, Kåreholt I, Eskelinen M, Winblad B, et al. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. J Cell Mol Med. 2008;12:2762-71 pubmed publisher
    ..The aim of this study was to investigate the effects and putative interactions between the apoE epsilon4 allele and lifestyle related risk factors for dementia and AD...
  71. Antunez C, Boada M, Gonzalez Perez A, Gayan J, Ramirez Lorca R, Marin J, et al. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Med. 2011;3:33 pubmed publisher
    ..40E-11, odds ratio = 0.88, 95% confidence interval 0.85 to 0.91, n = 10,181 cases and 14,341 controls). Our results underscore the importance of international efforts combining GWAS datasets to isolate genetic loci for complex diseases. ..
  72. Chun S, Min W, Kim J, Park H, Jang S, Yang S, et al. Apolipoprotein E polymorphism and serum lipoprotein(a) concentrations in a Korean male population. Ann Clin Biochem. 2001;38:129-34 pubmed
    The purpose of this study was to investigate the effect of apolipoprotein E polymorphism on lipoprotein(a) metabolism by comparing serum lipoprotein(a) concentration with apolipoprotein E genotype in a Korean male population whose high ..
  73. Hashimoto M, Yasuda M, Tanimukai S, Matsui M, Hirono N, Kazui H, et al. Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease. Neurology. 2001;57:1461-6 pubmed
    Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial...
  74. Gong J, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita S, et al. Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J Biol Chem. 2002;277:29919-26 pubmed
    ..Isobe, I., and Yanagisawa, K. (2000) J. Neurochem. 74, 1008-1016) that exogenously added recombinant human apolipoprotein E (apoE) promotes cholesterol release in an isoform-dependent manner...
  75. Chang S, Hou M, Tsai S, Kao J, Wu S, Hou L, et al. Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese. Breast Cancer Res Treat. 2006;98:109-13 pubmed
    To display the association between the apolipoprotein E (APOE) genotypes and breast cancer patients, a cross sectional study including 291 patients and 148 controls was performed...
  76. Olarte L, Schupf N, Lee J, Tang M, Santana V, Williamson J, et al. Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics. Arch Neurol. 2006;63:1586-90 pubmed
    The primary effect of the apolipoprotein E epsilon4 (APOE epsilon4) allele is on the age at onset of Alzheimer disease (AD)...
  77. Maruszak A, Canter J, Styczynska M, Zekanowski C, Barcikowska M. Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?. Neurobiol Aging. 2009;30:1749-55 pubmed publisher
    ..The frequency distribution of mtDNA haplogroups was non-randomly associated with APOE4 status (chi(2)=73.17, df=1, p<0.0001, OR=5.97, 95% CI 3.90-9...
  78. Bahia V, Kok F, Marie S, Shinjo S, Caramelli P, Nitrini R. Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. Alzheimer Dis Assoc Disord. 2008;22:61-5 pubmed publisher
    ..Putative genetic risk factors for AD are polymorphisms in the apolipoprotein E (APOE) gene and in the low-density lipoprotein receptor-related protein (LRP) gene...
  79. Xu G, McLaren D, Ries M, Fitzgerald M, Bendlin B, Rowley H, et al. The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory. Brain. 2009;132:383-91 pubmed publisher
    First-degree family history (FH) of sporadic Alzheimer's disease and the apolipoprotein E epsilon4 allele (APOE4) are risk factors for Alzheimer's disease that may affect brain function prior to onset of clinical symptoms...
  80. Sleegers K, Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn P, et al. Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. Hum Mutat. 2009;30:E338-44 pubmed publisher
    ..2 (GAB2) was recently reported to be a modifier of late-onset Alzheimer dementia (AD) risk in carriers of the APOE epsilon4 allele in a genome-wide association analysis...
  81. Katrancioglu N, Manduz S, Ozen F, Yilmaz M, Atahan E, Ozdemir O, et al. Association between ApoE4 allele and deep venous thrombosis: a pilot study. Clin Appl Thromb Hemost. 2011;17:225-8 pubmed publisher
    ..b>ApoE gene polymorphisms seem to have some impact among patients with cardiovascular disease; however, association ..
  82. Gamboa R, Hernandez Pacheco G, Hesiquio R, Zuniga J, Masso F, Montano L, et al. Apolipoprotein E polymorphism in the Indian and Mestizo populations of Mexico. Hum Biol. 2000;72:975-81 pubmed
    b>Apolipoprotein E (APOE) genotypes were determined in 75 Mazatecan Indians and 83 Mexican mestizos. APOE allele and genotype frequencies in Mazatecans and mestizos were similar, with high frequencies of the APOE*3 allele (0.900 and 0...
  83. Oh J, Barrett Connor E. Apolipoprotein E polymorphism and lipid levels differ by gender and family history of diabetes: the Rancho Bernardo Study. Clin Genet. 2001;60:132-7 pubmed
    Association between apolipoprotein E (apoE) gene polymorphism and lipid levels was studied in 164 nondiabetic first-degree relatives of persons with diabetes and 962 nondiabetic persons with no family history of diabetes...
  84. Lai S, Chen Y, Wen Z. [Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2001;22:202-4 pubmed
    To investigate the distribution of apolipoprotein E (apoE) genotype of patients with Alzheimer's disease (AD) in the population aged 75 and older in Guangzhou and to determine whether there was an association between AD and apoE epsilon4 ..
  85. Roks G, Cruts M, Houwing Duistermaat J, Dermaut B, Serneels S, Havekes L, et al. Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study. Am J Med Genet. 2002;114:570-3 pubmed
    The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE*2, APOE*3, and APOE*4 alleles influences plasma levels of apolipoprotein E and cholesterol...
  86. Stengård J, Clark A, Weiss K, Kardia S, Nickerson D, Salomaa V, et al. Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Am J Hum Genet. 2002;71:501-17 pubmed
    b>Apolipoprotein E (ApoE) is a major constituent of many lipoprotein particles...