Genomes and Genes
Gene Symbol: ApoE
Description: apolipoprotein E
Alias: AD2, LDLCQ5, LPG, apo-E, apolipoprotein E3
Publications208 found, 100 shown here
- Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's diseaseRobert A Sweet
Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
J Geriatr Psychiatry Neurol 15:24-30. 2002..b>APOE and ACT genotyping was conducted per established protocols...
- Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene databaseLars Bertram
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Nat Genet 39:17-23. 2007..In addition to identifying the epsilon4 allele of APOE and related effects, we pinpointed over a dozen potential Alzheimer disease susceptibility genes (ACE, CHRNB2, CST3,..
- Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processesFatos Bejta
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St, London NW1 0TU, UK
Biochim Biophys Acta 1771:901-10. 2007..Thus, the effects of CMR oxidation on foam cell formation contrast sharply with those of LDL oxidation and this may be important in the role of dietary oxidized lipids and antioxidants in modulating atherosclerosis...
- Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer diseaseHao Li
GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Arch Neurol 65:45-53. 2008..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
- Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's diseaseNicola Filippini
The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
Neuroimage 44:724-8. 2009b>APOE epsilon4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD)...
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's diseaseJean Charles Lambert
INSERM U744, Lille, France
Nat Genet 41:1094-9. 2009The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease...
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseDenise Harold
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Nat Genet 41:1088-93. 2009..In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1...
- Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
- GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriersEric M Reiman
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
Neuron 54:713-20. 2007The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD)...
- Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesE H Corder
Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
Science 261:921-3. 1993The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD)...
- A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's diseaseKeith D Coon
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz 85004, USA
J Clin Psychiatry 68:613-8. 2007While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19...
- Apolipoprotein E: far more than a lipid transport proteinR W Mahley
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
Annu Rev Genomics Hum Genet 1:507-37. 2000..b>ApoE is a polymorphic protein arising from three alleles at a single gene locus...
- The role of apolipoprotein E in Alzheimer's diseaseJungsu Kim
Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 63:287-303. 2009The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD)...
- APOE gene polymorphisms and response to statin therapyE Zintzaras
Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
Pharmacogenomics J 9:248-57. 2009Published studies investigating the role of APOE gene on lipid response (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides) to statin treatment have ..
- APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general populationRafael O Alvim
Heart Institute InCor, University of Sao Paulo Medical School, Brazil
Lipids Health Dis 9:128. 2010..The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population...
- Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional lociJoseph H Lee
Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Neurol 65:1518-26. 2008..To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD)...
- Apolipoprotein E polymorphism--a risk factor for metabolic syndromeAnca Sima
Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Clin Chem Lab Med 45:1149-53. 2007..The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications.
- The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptorJose Ruiz
Department of Surgery, University of Maryland School of Medicine, Rockville, MD 21201, USA
J Lipid Res 46:1721-31. 2005Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with members of the LDL receptor family. ApoE exists as three common isoforms that have important distinct functional and biological properties...
- Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13Ralph Burkhardt
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA
Arterioscler Thromb Vasc Biol 28:2078-84. 2008..CONCLUSIONS: We identified variants in HMGCR that are associated with LDL-C across populations and affect alternative splicing of HMGCR exon13...
- MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PETL Mosconi
Department of Clinical Pathophysiology, University of Florence, Florence, Italy
Neurology 63:2332-40. 2004To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD).
- Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyR W Mahley
Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
Science 240:622-30. 1988..Other functions of apolipoprotein E, unrelated to lipid transport, are becoming known, including immunoregulation and modulation of cell growth and differentiation...
- Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriersA C Burggren
David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, 760 Westwood Plaza B8 169, Los Angeles, CA 90095, USA
Neuroimage 41:1177-83. 2008Our objective was to investigate whether asymptomatic carriers of apolipoprotein E epsilon4 [APOE-4] demonstrate pathological differences and atrophy in medial temporal lobe (MTL) subregions...
- The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degenerationPaul N Baird
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 45:1311-5. 2004..of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease...
- APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out miceMatthew J Sharman
Centre of Excellence for Alzheimer s Disease Research and Care, Edith Cowan University, Joondalup, WA, Australia
J Alzheimers Dis 21:403-9. 2010The epsilon4 allele of apolipoprotein E (APOE) is currently the major genetic risk factor identified for Alzheimer's disease (AD)...
- Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoformsK H Weisgraber
J Biol Chem 256:9077-83. 1981
- Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohortJohn F Thompson
Helicos BioSciences, Cambridge, MA, USA
Circ Cardiovasc Genet 2:173-81. 2009..To address this, 5745 individuals from the Treating to New Targets (TNT) trial were genotyped in a combination of a whole-genome and candidate gene approach to identify associations with response to atorvastatin treatment...
- Effect of apoE genotype on the hypolipidaemic response to pravastatin in an outpatient settingR Pena
Unidad de Arteriosclerosis, Hospital Carlos III, Madrid, Spain
J Intern Med 251:518-25. 2002..The gene for apolipoprotein E (ApoE) is polymorphic and the different genotypes modulate baseline lipid levels...
- Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodiesAndrew B Singleton
Medical Research Council University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 14:167-75. 2002..The apolipoprotein E (APO E) epsilon4 allele is the most consistently associated genetic risk factor for AD and has also been shown to ..
- Obesity modulates the association among APOE genotype, insulin, and glucose in menRoberto Elosua
Nutrition and Genomics Laboratory and Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Obes Res 11:1502-8. 2003Obesity, insulin resistance, and apolipoprotein E (APOE) genotype have all been associated with coronary heart disease. We examined the interaction between obesity and APOE genotype in determining fasting insulin and glucose levels.
- Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in PolandCezary Zekanowski
Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
Exp Neurol 184:991-6. 2003..It could be concluded that screening for mutations in the three genes could be included in a diagnostic program directed at patients with a positive family history or age of onset before 55 years...
- Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic miceWalter J Brecht
Gladstone Institute of Neurological Disease, San Francisco, California 94141 9100, USA
J Neurosci 24:2527-34. 2004Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear...
- Examination of the current top candidate genes for AD in a genome-wide association studyT M Feulner
Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
Mol Psychiatry 15:756-66. 2010..Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD...
- Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholineClare A Peters-Libeu
Gladstone Institute of Cardiovascular Disease and Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
J Biol Chem 281:1073-9. 2006..This interaction requires apoE to be associated with a lipoprotein particle...
- Structural and functional variations in human apolipoprotein E3 and E4Chi Yuan Chou
Faculty of Life Sciences, Institute of Biochemistry, Structural Biology Program, National Yang Ming University, Taipei, Taiwan
J Biol Chem 281:13333-44. 2006There are three major apolipoprotein E (apoE) isoforms. Although APOE-epsilon3 is considered a longevity gene, APOE-epsilon4 is a dual risk factor to atherosclerosis and Alzheimer disease...
- Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding propertiesAngeliki Chroni
Institute of Biology, National Centre for Scientific Research Demokritos, Aghia Paraskevi, Athens 15310, Greece
Biochemistry 47:9071-80. 2008....
- Better memory and neural efficiency in young apolipoprotein E epsilon4 carriersChristian R A Mondadori
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Cereb Cortex 17:1934-47. 2007The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown...
- Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS studyLouise A Donnelly
Division of Community Health Sciences, Mackenzie Building, Kirsty Semple Way, Dundee, Scotland, UK
Pharmacogenet Genomics 18:279-87. 2008Apolipoprotein E (APOE) genotypes have been associated with variations in plasma-lipid levels and with response to statins, although the influence of APOE on the response to statins remains controversial, especially in patients with ..
- Does the geographical gradient of ApoE4 allele exist in China? A systemic comparison among multiple Chinese populationsPeng Hu
Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, No 218 Ji Xi Road, Hefei, 230022, People s Republic of China
Mol Biol Rep 38:489-94. 2011The allelic frequencies of apolipoprotein E (apoE) vary substantially around the world...
- Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseasesShajith Anoop
Department of Environmental Sciences, Bharathiar University, Coimbatore, India
Indian J Med Res 132:363-78. 2010The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E)...
- Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic miceFaith M Harris
Gladstone Institute of Neurological Disease, San Francisco, CA 94141 9100, USA
Proc Natl Acad Sci U S A 100:10966-71. 2003..However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation of ..
- Association of apolipoprotein E genotypes with lipid levels and coronary riskAnna M Bennet
Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
JAMA 298:1300-11. 2007Previous reviews of associations of apolipoprotein E (apoE) genotype and coronary disease have been dominated by smaller studies that are liable to biases.
- APOE genotype, lipids, and coronary heart disease risk: a prospective population studyHeather Ward
Medical Research Council MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Institute of Public Health, University of Cambridge, Cambridge, England
Arch Intern Med 169:1424-9. 2009..The risk of coronary heart disease (CHD) may be related to genetic mutations in the production of apolipoprotein E via alterations to the metabolism of CHD-related blood lipids such as low-density lipoprotein cholesterol and triglycerides...
- The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo EuropeNadia Haddy
INSERM U 525 Equipe 4, 30 rue Lionnois, 54000 Nancy, France
Eur J Hum Genet 10:841-50. 2002..This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: ..
- The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndromeF Cardona
Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, 29009 Malaga, Spain
J Clin Endocrinol Metab 90:2972-5. 2005Apolipoprotein E (apo E) is a constituent molecule of the triglyceride-rich lipoproteins and participates in their clearance. Polymorphisms in the apo E gene are associated with increased fasting and postprandial levels of triglycerides...
- The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapyTim A Ahles
Department of Psychiatry and Center for Psycho Oncology Research, USA
Psychooncology 12:612-9. 2003..the neuropsychological performance of long-term survivors of breast cancer and lymphoma treated with standard dose chemotherapy who carried the epsilon 4 allele of the Apolipoprotein E (APOE) gene to those who carry other APOE alleles.
- APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycleC J Carter
Neurosci Lett 483:96-100. 2010The major Alzheimer's disease susceptibility genes (APOE, clusterin, complement receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein, PICALM) can be implicated directly (APOE, CR1) or indirectly (clusterin and ..
- Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patientsF I V Errera
Centro de Estudos do Genoma Humano, Instituto de Biociencias, USP, Sao Paulo, SP, Brasil
Braz J Med Biol Res 39:883-8. 2006..genes for DM and its complications, and the 5-10-methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein-E (APOE) genes have been considered good candidate susceptibility genes to this condition...
- Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and genderS Schmidt
Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Mol Vis 6:287-93. 2000..It has been previously suggested that the e4 allele of the apolipoprotein E (APOE) gene may have a protective effect on AMD risk and that the e2 allele may increase disease risk...
- Apolipoprotein E polymorphism, age and coronary heart diseaseGenovefa D Kolovou
1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece
Ageing Res Rev 6:94-108. 2007..The most common apo E polymorphism has been found to influence blood lipid concentrations and its correlation with CHD has been ..
- An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's diseaseHanna Rosenmann
Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
Neurosci Lett 340:29-32. 2003..These findings show no evidence for an association between p53 codon 72 polymorphism and AD in our population...
- Polymorphisms in the apolipoprotein E gene regulatory region in relation to coronary heart disease and their effect on plasma apolipoprotein ER M Corbo
Department of Genetics and Molecular Biology, La Sapienza University, Rome, Italy
Clin Chem Lab Med 39:2-6. 2001..of male coronary heart disease (CHD) patients and controls, we found a significant excess of the genotypes carrying APOE*4 allele in CHD men (18.2%) vs. controls (9...
- [Apolipoprotein E4 in dementia with Lewy bodies]F Carrillo García
Servicio de Neurologia, Hospital Universitario Virgen del Rocio, Sevilla
Neurologia 23:152-6. 2008There is a strong association between the e4 allele of apolipoprotein E (APOE) and Alzheimer's disease (AD). This converts this allele into a risk factor for the development of AD...
- Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 alleleClaudia Giannattasio
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Dement Geriatr Cogn Disord 25:354-8. 2008We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients...
- fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's diseaseMehul A Trivedi
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuropsychologia 46:1667-78. 2008..study, we used fMRI to examine the influence of age on two other known risk factors for Alzheimer's disease (AD), APOE genotype and parental history of AD (FH status), during episodic encoding (ENC) and metacognitive self-appraisal (..
- Gene-diet interactions and plasma lipoproteins: role of apolipoprotein E and habitual saturated fat intakeH Campos
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Genet Epidemiol 20:117-128. 2001..LDL) particle size are modulated by an interaction between habitual saturated fat intake and apolipoprotein E (APOE) genotype, we studied 420 randomly selected free-living Costa Ricans. The APOE allele frequencies were 0...
- Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementiaEric M Reiman
Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
Proc Natl Acad Sci U S A 101:284-9. 2004..Carriers of a common Alzheimer's susceptibility gene have functional brain abnormalities in young adulthood, several decades before the possible onset of dementia...
- Clinical features of rapidly progressive Alzheimer's diseaseChristian Schmidt
Department of Neurology, Hospital of the Georg August University Goettingen, Goettingen, Germany
Dement Geriatr Cogn Disord 29:371-8. 2010..To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD)...
- [Analysis on association between the polymorphisms in apolipoprotein E, interleukin-1 alpha genes and Alzheimer's disease in Chengdu area]Mu Ni Tang
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:176-8. 2004To investigate the correlation between the polymorphisms of apolipoprotein E(APOE), the interleukin-1 alpha (IL-1 alpha ) genes and the susceptibility to Alzheimer's disease(AD).
- Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's diseaseA Poleggi
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Eur J Neurol 15:173-8. 2008..for the PRNP polymorphism in AD compared to controls either in Probable or in Definite AD series even after stratification for APOE polymorphism. This study does not support a role of PRNP polymorphism as a susceptibility factor for AD.
- APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sampleJaroslav A Hubacek
Institute of Clinical and Experimental Medicine, Prague, Czech Republic
Hum Immunol 71:304-8. 2010The published data remain inconsistent on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP), mainly because of low statistical power of previous studies...
- Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer diseaseCristiano Capurso
Department of Geriatrics, University of Foggia, Foggia, Italy
Rejuvenation Res 13:645-52. 2010..157 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotyped for the apolipoprotein E (APOE) polymorphism and the GSTO1 rs4925 and rs1804834 SNPs...
- Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assaysOlga Calero
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Spain
J Neurosci Methods 183:238-40. 2009The apolipoprotein E gene (APOE) polymorphism genotyping has an allegedly important predictive value for coronary heart disorders and Alzheimer's disease...
- Association of injury severity, MRI-results and ApoE genotype with 1-year outcome in mainly mild TBI: a preliminary studyHeli Hiekkanen
Department of Neurology, Turku University Central Hospital, Turku, Finland
Brain Inj 23:396-402. 2009To study the ability of MRI findings, apolipoprotein E (ApoE) genotype, the Glasgow Coma Score (GCS) and duration of post-traumatic amnesia (PTA) to predict the 1-year outcome in traumatic brain injury (TBI).
- Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatinJanet J Maguire
Clinical Pharmacology Unit, Level 6 Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Exp Biol Med (Maywood) 231:806-12. 2006..ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 ..
- Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathwayLarissa C Wilsie
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, MSC08 4670 1 University of New Mexico, Albuquerque, New Mexico, 87131, USA
Lipids Health Dis 5:23. 2006..Receptor-mediated uptake of these particles is dependent upon prior association with apolipoprotein E (apoE-VLDL) and is brought about by cell surface heparan sulfate proteoglycans (HSPG) in some cell types and by the low ..
- Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTPRobert M Cohen
Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Synapse 60:86-92. 2006The apolipoprotein E-epsilon4 allele (APOE-epsilon4) confers greater susceptibility to age-related memory disorders...
- Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxingB D Jordan
Department of Neurology and Neuroscience, New York Hospital Cornell University Medical College, NY, USA
JAMA 278:136-40. 1997..between Alzheimer disease and dementia pugilistica, we evaluated the relationship between apolipoprotein E (APOE) genotype and chronic traumatic brain injury (CTBI) in boxers to determine whether there is a genetic ..
- Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis ConsortiumL A Farrer
Department of Neurology, Boston University School of Medicine, Mass 02118, USA
JAMA 278:1349-56. 1997To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations.
- Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular diseaseY Nakata
Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
Am J Hypertens 10:1391-5. 1997..threonine allele of the angiotensinogen gene (AGN/TT), and the epsilon4 allele of the apolipoprotein E gene (apoE/epsilon4) are reported to be associated with ischemic heart disease...
- LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in miceKyriakos E Kypreos
Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
J Lipid Res 47:521-9. 2006We have used adenovirus-mediated gene transfer and bolus injection of purified apolipoprotein E (apoE) in mice to determine the contribution of LDL receptor family members in the clearance of apoE-containing lipoproteins in vivo and the ..
- Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathwayR A Srivastava
Division of Atherosclerosis, Nutrition and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 272:33360-6. 1997..Raising plasma apolipoprotein E (apoE) in mice protects them against diet-induced atherosclerosis (Shimano, H., Yamada, N., Katsuki, M., Gotoda, T...
- Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the geneDebomoy K Lahiri
Department of Psychiatry and of Medical and Molecular Genetics, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Mol Neurosci 23:225-33. 2004..Apolipoprotein E (ApoE) has also been shown to colocalize with these neuropathological lesions. Here is reviewed the role of ApoE in AD...
- ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpressionGery Gerritsen
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
J Lipid Res 46:1466-73. 2005Adenovirus-mediated overexpression of human apolipoprotein E (apoE) induces hyperlipidemia by stimulating the VLDL-triglyceride (TG) production rate and inhibiting the LPL-mediated VLDL-TG hydrolysis rate...
- Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic miceS Bonthu
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242 1081, USA
Arterioscler Thromb Vasc Biol 17:2333-40. 1997..structure and endothelium-dependent relaxation in two genetic models of hypercholesterolemia: apolipoprotein E (apoE)-knockout mice and combined apoE/LDL receptor-double-knockout mice...
- A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortalityI Skoog
Department of Psychiatry, Sahlgrenska Hospital Institute of Clinical Neurosciences, Goteborg University, Sweden
J Neurol Neurosurg Psychiatry 64:37-43. 1998To study the association of apoE genotypes with dementia and cerebrovascular disorders in a population based sample of 85 year old people.
- Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1Yan Ru Su
Atherosclerosis Research Unit, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
Circulation 111:2373-81. 2005Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular cholesterol homeostasis and therefore play critical roles in foam cell formation...
- Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosisM Van Eck
Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands
Arterioscler Thromb Vasc Biol 17:3117-26. 1997Apolipoprotein E (apoE), a high-affinity ligand for lipoprotein receptors, is synthesized by the liver and extrahepatic tissues, including cells of the monocyte/macrophage lineage...
- Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot studyA Loktionov
Medical Research Council, Dunn Clinical Nutrition Centre, Cambridge, UK
Br J Nutr 79:133-9. 1998Apolipoprotein E (ApoE) genotype was determined in sixty-five subjects who had taken part in a 4-week randomized crossover trial to compare the effect of six mugs of black tea per day v...
- In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic miceB J van Vlijmen
TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
J Biol Chem 271:30595-602. 1996Apolipoprotein E*2(Arg-158 --> Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3-Leiden (APOE*3-Leiden) transgenic mice to study the variable expression of hyperlipoproteinemia ..
- Lack of association between schizophrenia and the apolipoprotein E epsilon 4 alleleE Jonsson
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Eur Arch Psychiatry Clin Neurosci 246:182-4. 1996The association between the epsilon 4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported...
- In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolismK Ikewaki
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
J Lipid Res 35:1809-19. 1994..Apolipoproteins A-I and E are two of the major apolipoproteins in HDL. Plasma apoA-I levels, but not apoE levels, have been reported to be decreased in patients with ABL...
- Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathwayB C Mortimer
Department of Physiology, University of Western Australia, Nedlands, Australia
J Biol Chem 270:28767-76. 1995..of chylomicron remnants in mice deficient in low density lipoprotein receptor (LDLr) or apolipoprotein E (apoE) was compared with that of control C57BL/6J mice...
- Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosisY Huang
Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, California 94141-9100, USA
J Biol Chem 272:22685-94. 1997..rabbits were produced that expressed high plasma levels (30-70 mg/dl) of human apolipoprotein (apo) E2(Cys-158), an apoE variant associated with the human genetic disorder type III hyperlipoproteinemia (HLP)...
- FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytesRui Lu
Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
J Lipid Res 50:1156-64. 2009Fibroblast growth factor 1 (FGF-1) enhances apolipoprotein E (apoE) expression and apoE-HDL biogenesis in autocrine fashion in astrocytes (Ito, J., Y. Nagayasu, R. Lu, A. Kheirollah, M. Hayashi, and S. Yokoyama...
- Accumulation of an apoE-poor subfraction of very low density lipoprotein in hypertriglyceridemic menA J Evans
Department of Medicine, University of Western Ontario, London, Canada
J Lipid Res 30:1691-701. 1989Studies were undertaken to investigate the mechanism of the marked accumulation of an apoE-poor very low density lipoprotein (VLDL) subfraction in untreated Type IV and IIb hypertriglyceridemic subjects...
- Discoidal complexes containing apolipoprotein E and their transformation by lecithin-cholesterol acyltransferaseE L Gong
Lawrence Berkeley Laboratory, University of California, Donner Laboratory, Berkeley 94720
Biochim Biophys Acta 1006:317-28. 1989..3.1.43) produced particles with properties comparable to those of core-containing, spherical, apoE-containing HDL in human plasma...
- Apolipoprotein E inhibits toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanismsYanjuan Zhu
Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
Biochem J 428:47-54. 2010Previous studies have shown that apoE (apolipoprotein E) expression in macrophages suppresses inflammatory responses; however, whether endogenously synthesized apoE acts intracellularly or after its secretion in suppressing macrophage ..
- Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formationMatthew J Eagleton
Deparment of Vascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Vasc Surg 51:951-61; discussion 961. 2010..The current study hypothesized that STAT1 regulates aneurysmal degeneration and its role was evaluated in human abdominal aortic aneurysm (AAA) and in a mouse model of aortic dissection...
- Association between apolipoprotein ε4 allele, factor V Leiden, and plasma lipid and lipoprotein levels with sickle cell disease in Southern IranZohreh Rahimi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mol Biol Rep 38:703-10. 2011To investigate whether there is any association between various APOE alleles and factor V Leiden (FVL) with lipid profiles and sickle cell disease (SCD) in Southern Iran...
- Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findingsMonika Madan
Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Massachusetts, United States of America
PLoS ONE 3:e3204. 2008..Toll-like receptors are principal sensors of the innate immune system. Here we report an assessment of the role of the TLR2 pathway in atherosclerosis associated with a high-fat diet and/or bacteria in ApoE(+/-) mice.
- Apolipoprotein E-/- mice have delayed skeletal muscle healing after hind limb ischemia-reperfusionJeanwan Kang
Department of Surgery, Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Vasc Surg 48:701-8. 2008..Mice with genetic deletion of apolipoprotein E (ApoE(-/-)) have been used as a model in various experimental scenarios of hypercholesterolemia...
- Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipaseS Y Choi
Research Institute, Palo Alto Medical Foundation, CA 94301
J Lipid Res 35:848-59. 1994b>ApoE is a ligand for the low density lipoprotein (LDL) receptor as well as for the LDL receptor-related protein (LRP). The enzyme hepatic lipase (HL) may also affect the uptake of lipoproteins by modifying their composition...
- Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytesJin Ichi Ito
Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
J Lipid Res 48:2020-7. 2007Fibroblast growth factor-1 (FGF-1) is secreted by astrocytes and stimulates apolipoprotein E (apoE)-HDL biogenesis by an autocrine mechanism to help in recovery from brain injury...
- Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophagesDongfang Wu
Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA
J Lipid Res 48:2571-8. 2007Apolipoprotein E (apoE) deficiency has been suggested to induce foam cell formation...
- Cellular sphingolipids regulate macrophage apolipoprotein E secretionDanijela Lucic
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Biochemistry 46:11196-204. 2007Macrophage-derived apolipoprotein E (apoE) in the vessel wall has important effects on the vessel-wall response to atherogenic injury...
- Elution of lipoprotein fractions containing apolipoproteins E and A-I in size exclusion on Superose 6 columns is sensitive to mobile phase pH and ionic strengthJ Westerlund
Lipid and Lipoprotein Research Group, University of Alberta, Edmonton, Canada
J Chromatogr A 718:59-66. 1995..By density ultracentrifugation, apoE and apoA-I were mostly (> 90%) confined to high-density lipoproteins (HDL, d = 1.063-1...
- 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null miceMarcos Martínez-Clemente
Department of Biochemistry and Molecular Genetics, Hospital Clinic, Centro de Investigación Biomédica Esther Koplowitz, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Hepatology 51:817-27. 2010..We recently demonstrated that hyperlipidemia-prone apolipoprotein E-deficient (ApoE(-/-)) mice exhibit hepatic steatosis and increased susceptibility to hepatic inflammation and advanced fibrosis...
- [Expressions of atherosclerosis-related genes in aorta in young apoE/LDLR double knockout mice]Xue dong Dai
The Key Laboratory of Animal Resistant Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan 250014, China
Sheng Li Xue Bao 60:43-50. 2008..inflammation impairment and pathogenesis of atherosclerosis (AS), total RNA was isolated from fresh aortas of young apoE/LDLR double knockout (apoE(-/-)/LDLR(-/-)) and wild type (WT) mice using TRIzol reagent...
- [Differential expressions of lipid metabolism related genes in the liver of young apoE knockout mice]Hong yan Ye
The Key Laboratory of Animal Resistant Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan 250014, China
Sheng Li Xue Bao 60:51-8. 2008..of lipid metabolism related genes in the early stage of atherosclerosis in the young apolipoprotein E deficient (apoE(-/-)) mice at different ages with normal chow diet...
- Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular changeC Czech
Center for Molecular Biology, Heidelberg, Germany
Eur Arch Psychiatry Clin Neurosci 243:291-2. 1994..01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts ..
- Pharmacogenomics and therapeutic prospects in dementiaRamon Cacabelos
EuroEspes Biomedical Research Center, Institute for CNS Disorders, 15166 Bergondo, Coruna, Spain
Eur Arch Psychiatry Clin Neurosci 258:28-47. 2008..amyloid cascade (APP, PS1, PS2) are only present in less than 5% of the AD population; however, the presence of the APOE-4 allele in the apolipoprotein E (APOE) gene represents a major risk factor for more than 40% of patients with ..
- EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITYROBERT O apos MARA RYAN; Fiscal Year: 2010..expressed protein ligation, will be employed to introduce stable isotopes into a specific, predetermined, region of apoE that is essential for LDLR binding. The research to be pursued includes three specific aims...
- Small Molecule Screen for Apolipoprotein-E/Alzheimer's DiseaseMICHAEL PETER VITEK; Fiscal Year: 2010..Behind age, the second largest risk factor for AD is APOE (apolipoprotein-E) genotype where APOE4 carriers are at significantly higher risk for AD than their non-APOE4 (..
- Functions of Lipoprotein Receptors in Alzheimer DiseaseG Rebeck; Fiscal Year: 2005DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...
- Amyloid Beta-Protein: ApoE and Cholesterol HomeostasisWELLINGTON WOOD; Fiscal Year: 2009This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
- Amyloid Beta-Protein: ApoE and Cholesterol HomeostasisWELLINGTON WOOD; Fiscal Year: 2007This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
- BONE MARROW TRANSPLANTION AND ATHEROSCLEROSISMacRae Linton; Fiscal Year: 1999..In the third specific aim, the role of apo E secretion by the macrophage in promoting cholesterol efflux will be tested in vitro, and bone marrow ..
- Activators of the Pyrophosphatase Activity of Alkaline PhosphataseJose Luis Millan; Fiscal Year: 2007..We examined the expression levels of TNAP in tissues from mice carrying one copy or two copies of the ApoE-Tnap transgene and also from [Akp2-/-; ApoE-Tnap] mice, and examined the ability of their primary osteoblasts to ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2010Individuals with apolipoprotein (Apo) E deficiency develop hypercholesterolemia and atherosclerosis. Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2009Individuals with apolipoprotein (Apo) E deficiency develop hypercholesterolemia and atherosclerosis. Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that ..
- Ocular HSV-Latency, Reactivation, and RecurrenceJames Hill; Fiscal Year: 2009..The e4 allele of Apolipoprotein E (ApoE) is a risk factor for ocular herpes...
- Ocular HSV-Latency, Reactivation, and RecurrenceJames M Hill; Fiscal Year: 2010..The e4 allele of Apolipoprotein E (ApoE) is a risk factor for ocular herpes...
- ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESISDavid Williams; Fiscal Year: 1999..b>ApoE plays a key role in lipoprotein metabolism by acting as a ligand for hepatic receptors that mediate the rapid ..
- Impact of Aging on Stem Cell Repair in AtherosclerosisPascal Goldschmidt Clermont; Fiscal Year: 2004..BM) cells significantly reduced atherosclerotic lesion formation in an established mouse model of atherosclerosis--ApoE / C57/B6 mice fed high fat/cholesterol, Western-type diet--even in the absence of restoration of ApoE gene ..
- Impact of Aging on Stem Cell Repair in AtherosclerosisPascal Goldschmidt Clermont; Fiscal Year: 2007..BM) cells significantly reduced atherosclerotic lesion formation in an established mouse model of atherosclerosis--ApoE "/" C57/B6 mice fed high fatcholesterol, Western-type diet--even in the absence of restoration of ApoE gene ..
- APOLIPOPROTEIN E--IMPACT ON VASCULAR CELL FUNCTIONSDavid Hui; Fiscal Year: 2002..However, most of the research on the role of apoE has focused on its role in cholesterol metabolism...
- Impact of Aging on Stem Cell Repair in AtherosclerosisPascal Goldschmidt Clermont; Fiscal Year: 2007..cells significantly reduced atherosclerotic lesion formation in an established mouse model of atherosclerosis --ApoE -/- C57/B6 mice fed high fat cholesterol, Western-type diet--even in the absence of restoration of ApoE gene ..
- HEPATIC METABOLISM OF DIET DERIVED LIPOPROTIENSALLEN COOPER; Fiscal Year: 2003..The latter, is determined in part, by co-factors, particularly hepatic apoE. Three specific aims are proposed...
- EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITYRobert Ryan; Fiscal Year: 2009..Knowledge of the metabolic roles of apolipoprotein E (apoE) and the low density lipoprotein receptor (LDLR) will be combined with available structural information in the ..
- EFFECTS OF APOE ON OLFACTORY NEURON PLASTICITY IN MICEBritto Nathan; Fiscal Year: 2005Apolipoprotein E (apoE), a lipid transporting protein, is a major risk factor for developing Alzheimer's disease (AD). However, the contribution of apoE to nervous system function, and developing AD are unknown...
- FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORSSergio Fazio; Fiscal Year: 2009..In the previous cycle of this grant, we discovered that LRP1 deletion from macrophages leads to increased apoE synthesis and, surprisingly, increased lesion formation...
- FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORSSergio Fazio; Fiscal Year: 2010..In the previous cycle of this grant, we discovered that LRP1 deletion from macrophages leads to increased apoE synthesis and, surprisingly, increased lesion formation...