Genomes and Genes
Gene Symbol: ApoE
Description: apolipoprotein E
Alias: AD2, LDLCQ5, LPG, apo-E, apolipoprotein E3
Publications272 found, 100 shown here
- Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene databaseLars Bertram
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Nat Genet 39:17-23. 2007..In addition to identifying the epsilon4 allele of APOE and related effects, we pinpointed over a dozen potential Alzheimer disease susceptibility genes (ACE, CHRNB2, CST3,..
- Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processesFatos Bejta
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St, London NW1 0TU, UK
Biochim Biophys Acta 1771:901-10. 2007..Thus, the effects of CMR oxidation on foam cell formation contrast sharply with those of LDL oxidation and this may be important in the role of dietary oxidized lipids and antioxidants in modulating atherosclerosis...
- Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer diseaseHao Li
GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Arch Neurol 65:45-53. 2008..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
- Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's diseaseNicola Filippini
The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
Neuroimage 44:724-8. 2009b>APOE epsilon4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD)...
- Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesE H Corder
Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
Science 261:921-3. 1993The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD)...
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseDenise Harold
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Nat Genet 41:1088-93. 2009..In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1...
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's diseaseJean Charles Lambert
INSERM U744, Lille, France
Nat Genet 41:1094-9. 2009The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease...
- Distinct patterns of brain activity in young carriers of the APOE-epsilon4 alleleNicola Filippini
University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 106:7209-14. 2009The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects...
- Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
- GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriersEric M Reiman
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
Neuron 54:713-20. 2007The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD)...
- Apolipoprotein E: far more than a lipid transport proteinR W Mahley
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
Annu Rev Genomics Hum Genet 1:507-37. 2000..b>ApoE is a polymorphic protein arising from three alleles at a single gene locus...
- Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's diseaseSteven G Potkin
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
PLoS ONE 4:e6501. 2009With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown.
- A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's diseaseKeith D Coon
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz 85004, USA
J Clin Psychiatry 68:613-8. 2007While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19...
- Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition StudyLaura Jean Podewils
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Epidemiol 161:639-51. 2005..79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers...
- ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recyclingYing Chen
Department of Molecular Genetics, Center for Alzheimer s and Neurodegenerative Disease, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 107:12011-6. 2010Apolipoprotein E (ApoE) genotype is a powerful genetic modifier of Alzheimer's disease (AD). The ApoE4 isoform significantly reduces the mean age-of-onset of dementia through unknown mechanisms...
- Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementiaEric M Reiman
Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
Proc Natl Acad Sci U S A 101:284-9. 2004..Carriers of a common Alzheimer's susceptibility gene have functional brain abnormalities in young adulthood, several decades before the possible onset of dementia...
- fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer diseaseMark W Bondi
University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Neurology 64:501-8. 2005To determine whether APOE genotype influences brain response and whether nonverbal stimuli generate findings comparable with those of previous studies that used verbal stimuli...
- The effects of APOE on the functional architecture of the resting brainAaron J Trachtenberg
Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, University of Oxford, Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom
Neuroimage 59:565-72. 2012There is a well-established association between APOE genotype and the risk of developing Alzheimer's disease (AD)...
- APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42Yvette I Sheline
Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 30:17035-40. 2010....
- Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohortS Kim
Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
Neurology 76:69-79. 2011..We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42)...
- Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic miceFaith M Harris
Gladstone Institute of Neurological Disease, San Francisco, CA 94141 9100, USA
Proc Natl Acad Sci U S A 100:10966-71. 2003..However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation of ..
- The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degenerationPaul N Baird
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 45:1311-5. 2004..of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease...
- The role of apolipoprotein E in Alzheimer's diseaseJungsu Kim
Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 63:287-303. 2009The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD)...
- Differential effects of the APOE genotype on brain function across the lifespanN Filippini
University Department of Psychiatry, University of Oxford, Oxford, UK
Neuroimage 54:602-10. 2011Increasing age and carrying an APOE ε4 allele are well established risk factors for Alzheimer's disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an accelerated aging process...
- Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosisP M Sullivan
Department of Pathology and Laboratory of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
J Biol Chem 272:17972-80. 1997..The levels of apoE mRNA in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and their littermates ..
- Examination of the current top candidate genes for AD in a genome-wide association studyT M Feulner
Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
Mol Psychiatry 15:756-66. 2010..Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD...
- Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyR W Mahley
Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
Science 240:622-30. 1988..Other functions of apolipoprotein E, unrelated to lipid transport, are becoming known, including immunoregulation and modulation of cell growth and differentiation...
- Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleDavid G Cook
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Am J Pathol 162:313-9. 2003..shown that AD patients exhibit abnormalities in insulin metabolism that are associated with apoliprotein E (APOE) status...
- ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivoSonya B Dumanis
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
J Neurosci 29:15317-22. 2009The three human alleles of apolipoprotein E (APOE) differentially influence outcome after CNS injury and affect one's risk of developing Alzheimer's disease (AD)...
- Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriersA C Burggren
David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, 760 Westwood Plaza B8 169, Los Angeles, CA 90095, USA
Neuroimage 41:1177-83. 2008Our objective was to investigate whether asymptomatic carriers of apolipoprotein E epsilon4 [APOE-4] demonstrate pathological differences and atrophy in medial temporal lobe (MTL) subregions...
- Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle ageEloise Kok
Department of Forensic Medicine, Medical School, University of Tampere, Tampere, Finland
Ann Neurol 65:650-7. 2009..age dependency of senile plaques (SP) and neurofibrillary tangles (NFT), the brain changes characteristic of Alzheimer disease (AD), and their association with apolipoprotein E (APOE) genotypes in a community-dwelling normal population.
- MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PETL Mosconi
Department of Clinical Pathophysiology, University of Florence, Florence, Italy
Neurology 63:2332-40. 2004To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD).
- Multilocus analysis of age-related macular degenerationJulie Bergeron-Sawitzke
SAIC Frederick, Basic Science Program, Human Genetics Section, Frederick, MD 21702 1201, USA
Eur J Hum Genet 17:1190-9. 2009..B (CFB), age-related maculopathy susceptibility (ARMS2), HtrA serine peptidase 1 (HTRA1), and apolipoprotein E (APOE)...
- The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriersMin Wang
Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China
Neurosci Lett 482:260-3. 2010..Definitive genotyping of these markers and apolipoprotein E (APOE) polymorphism were surveyed in 341 SAD patients and 421 controls...
- Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOELynn M Bekris
Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
J Hum Genet 57:18-25. 2012Genetic variation within the apolipoprotein E gene (APOE) locus is associated with late-onset Alzheimer's disease risk and quantitative traits as well as apoE expression in multiple tissues...
- Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adultsTanja Richter-Schmidinger
Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
J Neural Transm 118:249-57. 2011Unravelling the impact of genetic variants on clinical phenotypes is a challenging task. Apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) play an important role in cell growth, regeneration, synaptic plasticity, ..
- An association study of 43 SNPs in 16 candidate genes with atorvastatin responseJ F Thompson
Discovery Pharmacogenomics, Pfizer Global Research and Development, Eastern Point Road, MS8118D 3069, Groton, CT 06340, USA
Pharmacogenomics J 5:352-8. 2005..The magnitude of all the differences found is sufficiently small that genetic data from these genes should not influence clinical decisions on statin administration...
- Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseasesShajith Anoop
Department of Environmental Sciences, Bharathiar University, Coimbatore, India
Indian J Med Res 132:363-78. 2010The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E)...
- Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional lociJoseph H Lee
Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Neurol 65:1518-26. 2008..To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD)...
- Apolipoprotein E polymorphism--a risk factor for metabolic syndromeAnca Sima
Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Clin Chem Lab Med 45:1149-53. 2007..The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications.
- APOE gene polymorphisms and response to statin therapyE Zintzaras
Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
Pharmacogenomics J 9:248-57. 2009Published studies investigating the role of APOE gene on lipid response (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides) to statin treatment have ..
- APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general populationRafael O Alvim
Heart Institute InCor, University of Sao Paulo Medical School, Brazil
Lipids Health Dis 9:128. 2010..The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population...
- Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual lossP J Francis
Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
J Med Genet 46:300-7. 2009..This paper examines other AMD susceptibility genes to determine if these genotypes influenced disease progression and treatment response...
- Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?Aleksandra Maruszak
Department of Neurodegenerative Disorders, Polish Academy of Sciences Medical Research Center, 5 Pawinskiego Street, 02 106 Warsaw, Poland
Neurobiol Aging 30:1749-55. 2009..We conclude that further analysis of subtypes of haplogroup H would be necessary to decipher the relation of HV cluster with AD...
- Semantic memory activation in individuals at risk for developing Alzheimer diseaseM Seidenberg
Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
Neurology 73:612-20. 2009..event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names.
- The APOE ɛ4 allele modulates brain white matter integrity in healthy adultsV Heise
Department of Psychiatry, University of Oxford, Oxford, UK
Mol Psychiatry 16:908-16. 2011The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly ..
- Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary historyDan T A Eisenberg
Department of Anthropology, Northwestern University, Evanston, IL 60208, USA
Am J Phys Anthropol 143:100-11. 2010The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with increased cholesterol levels and heart disease...
- Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriersNancy A Dennis
Center for Cognitive Neuroscience, Duke University, Durham, NC, USA
Alzheimers Dement 6:303-11. 2010We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults.
- Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?J Persson
Department of Psychology, Umea University, S 901 87 Umea, Sweden
Neurology 66:1029-33. 2006Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly...
- Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 alleleHeather A Wishart
Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Dr, Lebanon, NH 03756 0001, USA
Am J Psychiatry 163:1603-10. 2006..The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults.
- Brain network local interconnectivity loss in aging APOE-4 allele carriersJesse A Brown
Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 108:20760-5. 2011Old age and possession of the APOE-4 allele are the two main risk factors for developing later onset Alzheimer's Disease (AD)...
- Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participantsKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
Am J Epidemiol 164:342-8. 2006..Apolipoprotein E (ApoE) has been widely studied in regard to its role in lipid transport and metabolism, but the role that ApoE genetic ..
- Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholineClare A Peters-Libeu
Gladstone Institute of Cardiovascular Disease and Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
J Biol Chem 281:1073-9. 2006..This interaction requires apoE to be associated with a lipoprotein particle...
- Better memory and neural efficiency in young apolipoprotein E epsilon4 carriersChristian R A Mondadori
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Cereb Cortex 17:1934-47. 2007The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown...
- Familial apolipoprotein E deficiencyE J Schaefer
J Clin Invest 78:1206-19. 1986..Homozygotes had only trace amounts of plasma apoE, and accumulations of apoB-48 and apoA-IV in VLDL, IDL, and low density lipoproteins...
- Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13Ralph Burkhardt
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA
Arterioscler Thromb Vasc Biol 28:2078-84. 2008..Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions...
- The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptorJose Ruiz
Department of Surgery, University of Maryland School of Medicine, Rockville, MD 21201, USA
J Lipid Res 46:1721-31. 2005Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with members of the LDL receptor family. ApoE exists as three common isoforms that have important distinct functional and biological properties...
- Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker associationChang En Yu
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Genomics 89:655-65. 2007The epsilon(4) allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer's disease (LOAD), but LOAD pathology does not all fit neatly around APOE...
- Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulationJoerg Heeren
Institute for Biochemistry and Molecular Biology II Molecular Cell Biology and Department of Internal Medicine, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Biol Chem 279:55483-92. 2004..involves the targeting of lipids and apoprotein B along the degradative pathway and the recycling of TRL-derived apoE through recycling endosomes...
- Longitudinal modeling of age-related memory decline and the APOE epsilon4 effectRichard J Caselli
Department of Neurology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
N Engl J Med 361:255-63. 2009The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease...
- Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effectsS Engelborghs
Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
J Neurol Neurosurg Psychiatry 74:1148-51. 2003..Strict diagnostic inclusion criteria were used to include well defined patients and controls. The results of apolipoprotein E (APOE) genotype effect on risk and clinical characteristics are presented.
- Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier modelKazuchika Nishitsuji
Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
J Biol Chem 286:17536-42. 2011Apolipoprotein E (apoE) is a major apolipoprotein in the brain. The ε4 allele of apoE is a major risk factor for Alzheimer disease, and apoE deficiency in mice leads to blood-brain barrier (BBB) leakage...
- Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility geneJon Valla
Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
J Alzheimers Dis 22:307-13. 2010In vivo PET imaging studies of young-adult carriers of the apolipoprotein E ε4 allele (APOEε4), the major Alzheimer's disease (AD) susceptibility gene, have demonstrated declines in glucose metabolism in brain areas later vulnerable to ..
- A case-control study on the effect of apoliprotein E genotype on head and neck cancer riskEmma De Feo
Institute of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy
Cancer Epidemiol Biomarkers Prev 19:2839-46. 2010The apolipoprotein E gene (apoE) has three major isoforms encoded by the ε2, ε3, and ε4 alleles, with the ε4 allele associated with hypercholesterolemia and the ε2 allele with the opposite effect...
- A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's diseaseJing Shi
Clinical Neuroscience Research Group, University of Manchester, Hope Hospital, Salford, M6 8HD, UK
Acta Neuropathol 111:15-20. 2006..genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele...
- Apolipoprotein E polymorphism and cardiovascular disease: a HuGE reviewJune E Eichner
Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Oklahoma City 73190, OK
Am J Epidemiol 155:487-95. 2002..examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease...
- Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase AYanjuan Zhu
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
J Biol Chem 278:36257-63. 2003..Previous studies revealed that apolipoprotein E (apoE) is an effective inhibitor of platelet-derived growth factor-directed smooth muscle cell migration and ..
- Comprehensive search for Alzheimer disease susceptibility loci in the APOE regionGyungah Jun
Department of Medicine Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA
Arch Neurol 69:1270-9. 2012..of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
- A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's diseaseFederico Licastro
Department of Experimental Pathology, School of Medicine, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
Neurobiol Aging 26:449-53. 2005..genotype was associated with an increased risk of EOAD independently from the presence of the apolipoprotein E (APOE) epsilon 4 allele...
- APOE related alterations in cerebral activation even at college ageN Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
J Neurol Neurosurg Psychiatry 76:1440-4. 2005Associations between the APOE genotype and various medical conditions have been documented at a very young age. The association between the APOE genotype and cognitive performance varies at different ages...
- E2 allele of the apolipoprotein E gene polymorphism is predictive for obesity status in Roma minority population of CroatiaHrvojka Marija Zeljko
Department of Internal Medicine, Clinical Hospital Merkur, Zajceva 19, 10000 Zagreb, Croatia
Lipids Health Dis 10:9. 2011..The present study explores whether the widely found cardiovascular diseases (CVD) risk effects of ACE I/D, APOE (ε2, ε3, ε4), eNOS-VNTR and LEP G2548A polymorphisms can be replicated in this specific population.
- White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machinesLaurence O'Dwyer
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
PLoS ONE 7:e36024. 2012....
- APOE genotype alters glial activation and loss of synaptic markers in miceYuangui Zhu
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Glia 60:559-69. 2012The ε4 allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and affects clinical outcomes of chronic and acute brain damages...
- Apolipoprotein E genotype and the cardiovascular disease risk phenotype: impact of sex and adiposity (the FINGEN study)Bettina M Kofler
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, United Kingdom
Atherosclerosis 221:467-70. 2012Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype × BMI/age/sex interactions...
- Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010The epsilon4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for Alzheimer's disease (AD), but limited work has suggested that APOE genotype may modulate disease phenotype...
- Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespanAlexander M Kulminski
Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
Aging Cell 10:533-41. 2011..We focus on the well-studied apolipoprotein E (APOE) e2/3/4 polymorphism and on lifespan and ages at onset of cardiovascular diseases (CVD) and cancer, using data on ..
- ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone diseaseJaime Sánchez-Cuén
División de Gastroenterología, Hospital Regional ISSSTE, Culiacan, Sinaloa 80230, Mexico
World J Gastroenterol 16:4685-90. 2010To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population.
- The relationship between apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphisms and hypertension: a meta-analysis of six studies comprising 1812 cases and 1762 controlsWenQuan Niu
Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China
Hypertens Res 32:1060-6. 2009We performed a meta-analysis in an effort to systematically explore the association between apolipoprotein E (ApoE) epsilon2/epsilon3/epsilon4 polymorphisms and hypertension...
- Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trialSamuel T Henderson
Accera, Inc, 380 Interlocken Crescent, Suite 780, Broomfield, Colorado 80021, USA
Nutr Metab (Lond) 6:31. 2009..abstract:..
- Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOEEllen M Wijsman
Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America
PLoS Genet 7:e1001308. 2011..SNPs near APOE gave highly significant results (e.g., rs2075650, p = 3...
- Genetic and clinical predictors of warfarin dose requirements in African AmericansL H Cavallari
Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA
Clin Pharmacol Ther 87:459-64. 2010..vitamin K oxidoreductase complex subunit 1 (VKORC1), cytochrome P450 2C9 (CYP2C9), CYP4F2, or apolipoprotein E (APOE) polymorphisms contribute to variability in the warfarin maintenance dose beyond what is attributable to the CYP2C9*..
- APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sampleJaroslav A Hubacek
Institute of Clinical and Experimental Medicine, Prague, Czech Republic
Hum Immunol 71:304-8. 2010The published data remain inconsistent on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP), mainly because of low statistical power of previous studies...
- An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's diseaseHanna Rosenmann
Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
Neurosci Lett 340:29-32. 2003..These findings show no evidence for an association between p53 codon 72 polymorphism and AD in our population...
- Characterization of the heparin binding sites in human apolipoprotein EHiroyuki Saito
Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Biol Chem 278:14782-7. 2003..Both the 22-kDa N-terminal domain and 10-kDa C-terminal domain of apoE contain a heparin binding site; the N-terminal site overlaps with the low density lipoprotein receptor binding ..
- Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNSQin Xu
Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
J Neurosci 28:1452-9. 2008..In studying how apoE expression is regulated in neurons, we identified a splicing variant of apoE mRNA with intron-3 retention (apoE-I3)...
- Apolipoprotein E genotype is related to progression of white matter lesion loadOphelia Godin
Inserm Unit 708 Neuroepidemiology, Hopital La Salpetriere, Paris, France
Stroke 40:3186-90. 2009..We investigated whether the apolipoprotein E genotype influences baseline and evolution over 4-year follow-up of WML volumes in a population-based sample of 1779 nondemented subjects aged 65 to 80 years old at enrollment...
- Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County StudyAra S Khachaturian
Khachaturian and Associates Inc, Potomac, MD, USA
Arch Gen Psychiatry 61:518-24. 2004..strongly with age, but little is known about the cumulative incidence of AD over a lifetime of 100 years, or its relationship to the polymorphic APOE locus that encodes apolipoprotein E. APOE is a strong genetic risk factor for AD.
- Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 alleleH A Wishart
Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH 03756 0001, USA
Neurology 67:1221-4. 2006To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele.
- The apolipoprotein E gene and its age-specific effects on cognitive functionFan Liu
Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
Neurobiol Aging 31:1831-3. 2010The E4 allele of the apolipoprotein E gene (APOE) is a well-established determinant of Alzheimer's disease but its relation to cognitive function is much less understood...
- ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African AmericansErdembileg Anuurad
Department of Medicine, University of California, Davis, CA, USA
J Lipid Res 50:1472-8. 2009..Functional polymorphisms have been established in apoE but not in apoC-I...
- Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer diseaseCristiano Capurso
Department of Geriatrics, University of Foggia, Foggia, Italy
Rejuvenation Res 13:645-52. 2010..157 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotyped for the apolipoprotein E (APOE) polymorphism and the GSTO1 rs4925 and rs1804834 SNPs...
- Apolipoprotein E and carotid artery atherosclerosis: the Rotterdam studyA J Slooter
Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
Stroke 32:1947-52. 2001..It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to atherosclerosis in the carotid arteries...
- APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycleC J Carter
Neurosci Lett 483:96-100. 2010The major Alzheimer's disease susceptibility genes (APOE, clusterin, complement receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein, PICALM) can be implicated directly (APOE, CR1) or indirectly (clusterin and ..
- Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controlsCathie Sudlow
Division of Clinical Neurosciences, University of Edinburgh, United Kingdom
Stroke 37:364-70. 2006Apolipoprotein E genotype (APOE) is associated with cholesterol metabolism, ischemic heart disease, and cerebral amyloid angiopathy, and so may affect risk of both ischemic and hemorrhagic stroke.
- Apolipoprotein E polymorphism, age and coronary heart diseaseGenovefa D Kolovou
1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece
Ageing Res Rev 6:94-108. 2007..The most common apo E polymorphism has been found to influence blood lipid concentrations and its correlation with CHD has been ..
- Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactionsBryan Maloney
Department of Psychiatry, Institute of Psychiatric Research, Laboratory of Molecular Neurogenetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Am J Med Genet B Neuropsychiatr Genet 153:185-201. 2010Variations in levels of apolipoprotein E (ApoE) have been tied to the risk and progression of Alzheimer's disease (AD)...
- Clinical features of rapidly progressive Alzheimer's diseaseChristian Schmidt
Department of Neurology, Hospital of the Georg August University Goettingen, Goettingen, Germany
Dement Geriatr Cogn Disord 29:371-8. 2010..To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD)...
- The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiolCandice M Brown
Division of Neurology, Duke University Medical Center, Durham, NC 27710, United States
Neurobiol Aging 29:1783-94. 2008..role, we examined the effect of 17beta-estradiol on the response of microglia to immune activation as a function of APOE genotype...
- Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart StudyRoberto Elosua
National Heart, Lung, and Blood Institute NIH, Framingham Heart Study, Framingham, MA, USA
J Lipid Res 45:1868-75. 2004The aim of this study was to determine the association between APOE genotype and carotid atherosclerosis, defined as intimal-medial thickness (IMT) and stenosis, and to assess if other cardiovascular risk factors modify this association...
- Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoformsK H Weisgraber
J Biol Chem 256:9077-83. 1981
- APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out miceMatthew J Sharman
Centre of Excellence for Alzheimer s Disease Research and Care, Edith Cowan University, Joondalup, WA, Australia
J Alzheimers Dis 21:403-9. 2010The epsilon4 allele of apolipoprotein E (APOE) is currently the major genetic risk factor identified for Alzheimer's disease (AD)...
- EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITYROBERT O apos MARA RYAN; Fiscal Year: 2010..expressed protein ligation, will be employed to introduce stable isotopes into a specific, predetermined, region of apoE that is essential for LDLR binding. The research to be pursued includes three specific aims...
- Functions of Lipoprotein Receptors in Alzheimer DiseaseG Rebeck; Fiscal Year: 2005DESCRIPTION (provided by the applicant): This application is a competing renewal of an R29 grant, "ApoE and its receptors in normal and Alzheimer's brain...
- Small Molecule Screen for Apolipoprotein-E/Alzheimer's DiseaseMICHAEL PETER VITEK; Fiscal Year: 2010..Behind age, the second largest risk factor for AD is APOE (apolipoprotein-E) genotype where APOE4 carriers are at significantly higher risk for AD than their non-APOE4 (..
- Amyloid Beta-Protein: ApoE and Cholesterol HomeostasisWELLINGTON WOOD; Fiscal Year: 2009This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
- Amyloid Beta-Protein: ApoE and Cholesterol HomeostasisWELLINGTON WOOD; Fiscal Year: 2007This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
- BONE MARROW TRANSPLANTION AND ATHEROSCLEROSISMacRae Linton; Fiscal Year: 1999..In the third specific aim, the role of apo E secretion by the macrophage in promoting cholesterol efflux will be tested in vitro, and bone marrow ..
- Activators of the Pyrophosphatase Activity of Alkaline PhosphataseJose Luis Millan; Fiscal Year: 2007..We examined the expression levels of TNAP in tissues from mice carrying one copy or two copies of the ApoE-Tnap transgene and also from [Akp2-/-; ApoE-Tnap] mice, and examined the ability of their primary osteoblasts to ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2009Individuals with apolipoprotein (Apo) E deficiency develop hypercholesterolemia and atherosclerosis. Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that ..
- Endoplasmic reticulum stress and foam cell formationZhongmao Guo; Fiscal Year: 2010Individuals with apolipoprotein (Apo) E deficiency develop hypercholesterolemia and atherosclerosis. Similarly, ApoE-deficient (ApoE-/-) mice elevate plasma ApoB48-carrying lipoproteins and develop atherosclerosis in a manner that ..
- Ocular HSV-Latency, Reactivation, and RecurrenceJames Hill; Fiscal Year: 2009..The e4 allele of Apolipoprotein E (ApoE) is a risk factor for ocular herpes...
- Ocular HSV-Latency, Reactivation, and RecurrenceJames M Hill; Fiscal Year: 2010..The e4 allele of Apolipoprotein E (ApoE) is a risk factor for ocular herpes...
- ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESISDavid Williams; Fiscal Year: 1999..b>ApoE plays a key role in lipoprotein metabolism by acting as a ligand for hepatic receptors that mediate the rapid ..
- Impact of Aging on Stem Cell Repair in AtherosclerosisPascal Goldschmidt Clermont; Fiscal Year: 2004..BM) cells significantly reduced atherosclerotic lesion formation in an established mouse model of atherosclerosis--ApoE / C57/B6 mice fed high fat/cholesterol, Western-type diet--even in the absence of restoration of ApoE gene ..
- Impact of Aging on Stem Cell Repair in AtherosclerosisPascal Goldschmidt Clermont; Fiscal Year: 2007..BM) cells significantly reduced atherosclerotic lesion formation in an established mouse model of atherosclerosis--ApoE "/" C57/B6 mice fed high fatcholesterol, Western-type diet--even in the absence of restoration of ApoE gene ..
- APOLIPOPROTEIN E--IMPACT ON VASCULAR CELL FUNCTIONSDavid Hui; Fiscal Year: 2002..However, most of the research on the role of apoE has focused on its role in cholesterol metabolism...
- Impact of Aging on Stem Cell Repair in AtherosclerosisPascal Goldschmidt Clermont; Fiscal Year: 2007..cells significantly reduced atherosclerotic lesion formation in an established mouse model of atherosclerosis --ApoE -/- C57/B6 mice fed high fat cholesterol, Western-type diet--even in the absence of restoration of ApoE gene ..
- HEPATIC METABOLISM OF DIET DERIVED LIPOPROTIENSALLEN COOPER; Fiscal Year: 2003..The latter, is determined in part, by co-factors, particularly hepatic apoE. Three specific aims are proposed...
- EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITYRobert Ryan; Fiscal Year: 2009..Knowledge of the metabolic roles of apolipoprotein E (apoE) and the low density lipoprotein receptor (LDLR) will be combined with available structural information in the ..
- EFFECTS OF APOE ON OLFACTORY NEURON PLASTICITY IN MICEBritto Nathan; Fiscal Year: 2005Apolipoprotein E (apoE), a lipid transporting protein, is a major risk factor for developing Alzheimer's disease (AD). However, the contribution of apoE to nervous system function, and developing AD are unknown...
- FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORSSergio Fazio; Fiscal Year: 2009..In the previous cycle of this grant, we discovered that LRP1 deletion from macrophages leads to increased apoE synthesis and, surprisingly, increased lesion formation...
- FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORSSergio Fazio; Fiscal Year: 2010..In the previous cycle of this grant, we discovered that LRP1 deletion from macrophages leads to increased apoE synthesis and, surprisingly, increased lesion formation...